CN105412607A - 一种治疗带状疱疹神经痛的外敷药及其制备方法 - Google Patents

一种治疗带状疱疹神经痛的外敷药及其制备方法 Download PDF

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CN105412607A
CN105412607A CN201511022213.5A CN201511022213A CN105412607A CN 105412607 A CN105412607 A CN 105412607A CN 201511022213 A CN201511022213 A CN 201511022213A CN 105412607 A CN105412607 A CN 105412607A
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宋磊
李中玮
吴朝玲
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Abstract

本发明提供了一种治疗带状疱疹神经痛的外敷药，其特征在于：由以下重量份原料药中的提取成分制成：两面针30份、七叶一枝花60份，薄荷9份，冰片9份，连翘30份，苦参50份，夏枯草40份，板蓝根30份，生甘草20份，黑豆30份，山慈姑60份，红大戟45份，千金子霜30份，五倍子30份，麝香9份，雄黄6份，阿魏酸钠1份，阿昔洛韦1份，维生素C？10份，维生素B12？0.005份。本发明采用中西医结合的方法，配伍使用中药与西药，各司其职，达到抗病毒、促组织恢复、减少疱疹渗出、错疱疹渗出液吸收、减轻疼痛、促进末梢神经功能恢复的作用，具有很高的治愈率和有效率，能够快速抑制病毒复制、缓解疱疹导致的神经痛，疗效显著优于现有药物。

Description

一种治疗带状疱疹神经痛的外敷药及其制备方法
技术领域
本发明涉及医疗药品，特别是涉及一种治疗带状疱疹神经痛的外敷药及其制备方法。
背景技术
带状疱疹是由水痘-带状疱疹病毒引发的病毒性皮肤病。对于带状疱疹，早期的治疗很关键，多数患者因未及时治疗或者治疗不当导致多种并发症出现。神经痛是带状疱疹的最常见并发症，剧烈神经痛及簇集水疱是带状疱疹发病时的典型症状。尤其是神经痛症状，由于疼痛部位不定、疼痛时间不定等因素给患者的生活质量造成了极大的影响，也是令病患而言最痛苦的并发症。目前常用的治疗方法是口服镇痛剂和涂抹一些止痛药膏。常用的非甾类消炎药对于钝痛的止痛效果较好，但是对于带状疱疹导致的神经痛效果很差，而吗啡一类的强效镇痛药成瘾性较大，不适合针对普通神经痛患者。止痛药膏多用双黄散、疱肤灵等，但是这些药膏的实际镇痛效果并不理想。
发明内容
本发明的目的在于克服传统药物镇痛效果差、无法有效遏制病毒复制的不足之处，提供一种镇痛效果好、能够有效抑制病毒复制的治疗带状疱疹神经痛的外敷药及其制备方法。
本发明的目的是通过以下技术措施来达到的：
一种治疗带状疱疹神经痛的外敷药，其特征在于：由以下重量份原料药中的提取成分制成：
两面针30份、七叶一枝花60份，薄荷9份，冰片9份，连翘30份，苦参50份，夏枯草40份，板蓝根30份，生甘草20份，黑豆30份，山慈姑60份，红大戟45份，千金子霜30份，五倍子30份，麝香9份，雄黄6份，阿魏酸钠1份，阿昔洛韦1份，维生素C10份，维生素B120.005份。
上述治疗带状疱疹神经痛的外敷药的制备方法：
按上述重量份称取各组分原料药，将两面针、七叶一枝花、连翘、苦参、夏枯草、板蓝根、山慈菇、五倍子、红大戟、生甘草和黑豆粉碎，加入75％乙醇1500份，加热回流提取3次，每次半小时，合并提取液后减压浓缩至无醇味，放置至温度降为常温；将雄黄、麝香、薄荷、冰片、千金子霜、阿魏酸钠、阿昔洛韦、维生素C和维生素B12均研细制为细粉，将细粉与浓缩提取液混匀；加入蒸馏水调节相对密度至1.1mg/ml-1.2mg/ml范围内；以γ射线辐照灭菌即得。
本发明的使用方法：将制备所得的液体涂抹于带状疱疹分布区和尚未出现疱疹但有神经痛的部位，每天涂抹3-4次，持续至疱疹吸收，神经痛症状消失为止。一般使用1周就可以显著缓解神经痛症状，疱疹大部分吸收，2-3周大多数即可痊愈。
带状疱疹病毒侵犯末梢神经后会导致持续的神经痛，这是患者最痛苦的症状，本发明将多管齐下，采用中西医结合的方式，针对带状疱疹病毒和其导致的神经痛症状分别进行多重治疗，具体而言，西药采用阿昔洛韦抗病毒，维生素C增强局部组织抵抗力，维生素B12治疗带状疱疹病毒导致的末梢神经炎，阿魏酸钠是川穹的有效成分，能够明显提高局部血流量，提高局部组织恢复能力；中药以两面针、七叶一枝花、连翘、苦参、夏枯草、板蓝根配伍行气止痛，祛风通络，解毒消肿，以红大戟、千金子霜、五倍子、雄黄、麝香配伍，通络散淤，收湿敛疮，减少疱疹渗出，以山慈姑、薄荷、冰片配伍散结化瘀，散毒镇痛，以生甘草和黑豆调和诸药，补肾益阴、解毒，调和减缓药物中的寒凉性，使本产品药力足而又没有过强刺激性，达到更好的治疗效果。
以下是各组分的药性分析。
两面针：味苦、辛，性平。能活血化瘀，行气止痛，祛风通络，解毒消肿。主治跌扑损伤，胃痛，牙痛，风湿痹痛，毒蛇咬伤；外治烧烫伤。
七叶一枝花：有清热解毒，消肿止痛，晾肝定惊之功效。用于疔疮肿痛，咽喉肿痛，蛇虫咬伤，跌扑伤痛，惊风抽搐。
薄荷：味辛，性凉。能疏散风热，清利头目，利咽透疹，疏肝行气。主治外感风热，头痛，咽喉肿痛，食滞气胀，口疮，牙痛，疮疥，瘾疹，温病初起，风疹瘙痒，肝郁气滞，胸闷胁痛。
冰片：辛苦，凉。具有清香宣散，具有开窍醒神，清热散毒，明目退翳的功效，主治热病高热神昏，中风痰厥惊痫，暑湿蒙蔽清窍，喉痹耳聋，口疮齿肿，疮痈疳痔，目赤肿痛，翳膜遮睛。
连翘：性味苦，凉，无毒。功能主治清热，解毒，散结，消肿。治温热，丹毒，斑疹，痈疡肿毒，瘰疬，小便淋闭。
苦参：味苦，性寒。功效清热燥湿，杀虫，利尿。主治热痢，便血，黄疸尿闭，赤白带下，阴肿阴痒，湿疹，湿疮，皮肤瘙痒，疥癣麻风，外治滴虫性阴道炎。
夏枯草：味辛苦，性寒。能清肝泻火，明目，散结消肿。主治目赤肿痛，目珠夜痛，头痛眩晕，瘰疬，瘿瘤，乳痈，乳癖，乳房胀痛。
板蓝根：性味苦，寒。功效清热解毒，凉血，利咽。主治温疫时毒，发热咽痛，温毒发斑，痄腮，烂喉丹痧，大头瘟疫，丹毒，痈肿。
黑豆，具有消肿下气、润肺清热、活血利水、祛风除痹、补血安神、明目健脾、补肾益阴、解毒的作用；用于水肿胀满风毒脚气、黄疽浮肿、风痹痉挛、产后疼、口襟、痈肿疮毒，可解药毒，制风热而止盗汗，乌须黑发以及延年益寿的功能。
山慈菇：性甘寒，有毒。功能主治：散结，化瘀。治咽喉肿痛，瘰疬，痈疽，疮肿，产后瘀滞。常用以治疗咽喉肿痛各种肿毒、小疔疮，常与雄黄、麝香、大戟、文蛤等配伍使用。
红大戟：味苦，性寒。能泻水逐饮，消肿散结。用于水肿胀满，胸腹积水，痰饮积聚，气逆咳喘，二便不利，痈肿疮毒，瘰疬痰核。
千金子霜：为千金子的炮制加工品。具有泻下逐水，破血消癥之功效，外用具有疗癣蚀疣之功效。常用于二便不通，水肿，痰饮，积滞胀满，血瘀经闭；外治顽癣，赘疣等病症的治疗。
五倍子：味酸、涩，性寒。敛肺降火，涩肠止泻，敛汗，止血，收湿敛疮。主治肺虚久咳，肺热痰嗽，久泻久痢，自汗盗汗，消渴，便血痔血，外伤出血，痈肿疮毒，皮肤湿烂。
麝香：性温、无毒、味苦。有开窍、辟秽、通络、散淤之功能。主治中风、痰厥、惊痫、中恶烦闷、心腹暴痛、跌打损伤、痈疽肿毒。
雄黄：性味辛味，性温。能解毒杀虫，燥湿祛痰，截疟。主治用于痈肿疔疮，蛇虫咬伤，虫积腹痛，惊痫，疟疾。
阿魏酸钠：主要用于动脉粥样硬化、冠心病、脑血管病、肾小球疾病、肺动脉高压、糖尿病性血管病变、脉管炎等血管性病症的辅助治疗，亦可用于偏头疼、血管性头疼的治疗。
阿昔洛韦为一种合成的嘌呤核苷类似物。主要用于单纯疱疹病毒、带状疱疹，EB病毒，及免疫缺陷者并发水痘等所致的各种感染，可用于初发或复发性皮肤、粘膜，外生殖器感染及免疫缺陷者发生的感染。具有很好的抗病毒活性和极低的副作用发生率。
维生素C，是一种抗氧化剂，保护身体免于自由基的威胁，维生素C同时也是一种辅酶，局部高浓度的维生素C能够显著提高细胞的免疫力，加快细胞功能的恢复。
维生素B12，是人体必需维生素之一，具有多种重要功能，其中之一就是能够维护神经系统健康，常用于治疗末梢神经炎、末梢神经麻痹以及神经疼、肌肉疼、关节疼等。
下面以临床对比试验治疗数据和典型治疗案例说明本发明的疗效。选取带状疱疹并伴有神经痛患者38名，随机分为治疗组和对照组，治疗组采用本发明治疗，对照组采用疱肤灵治疗，以疱疹和神经痛症状在四周内消失为痊愈，以疱疹和神经痛症状在四周内明显减轻为好转，四周内无明显改善为无效，痊愈和好转合并为有效率，观察疗效。
总数 痊愈人数 好转人数 无效人数 有效率
治疗组 19 15 3 1 94.7％
对照组 19 11 5 3 84.2％
案例1：患者赵某某，男，47岁，左胸部最先出现皮肤触觉过敏，2天后出现局部皮肤潮红，随后出现疱疹，并迅速连接成片，伴有显著的持续疼痛，使用本发明治疗，1周后疼痛显著减轻，疱疹开始减少，3周后疱疹完全消失，疼痛消失，痊愈。
案例2：患者张某某，男，36岁，右腹部出现皮肤潮红后迅速出现小疱疹，伴有疼痛，自服中药治疗无效，3天后疱疹加重并成片出现，疼痛显著，夜间难以入睡，使用本发明治疗，一周后疼痛减轻，疱疹开始减退，治疗3周疱疹消失，疼痛显著减轻，继续使用一周后症状完全消失，痊愈。
案例3：患者孙某某，女，53岁，右侧下胸部出现小疱疹，伴有疼痛，未在意，数日后疱疹增多，伴有明显神经痛，采用本发明局部涂抹，一周后症状明显减轻，3周后症状完全消失，痊愈。
由于采用了上述技术方案，与现有技术相比，本发明的优点是：
本发明公开了一种治疗带状疱疹神经痛的外敷药，采用中西医结合的方法，配伍使用中药与西药，各司其职，达到抗病毒、促组织恢复、减少疱疹渗出、错疱疹渗出液吸收、减轻疼痛、促进末梢神经功能恢复的作用，具有很高的治愈率和有效率，能够快速抑制病毒复制、缓解疱疹导致的神经痛，疗效显著优于现有药物。
下面结合具体实施方式对本发明作进一步说明。
具体实施方式
实施例1：一种治疗带状疱疹神经痛的外敷药，称取下重量份的原料药：
两面针30份、七叶一枝花60份，薄荷9份，冰片9份，连翘30份，苦参50份，夏枯草40份，板蓝根30份，生甘草20份，黑豆30份，山慈姑60份，红大戟45份，千金子霜30份，五倍子30份，麝香9份，雄黄6份，阿魏酸钠1份，阿昔洛韦1份，维生素C10份，维生素B120.005份。将上述原料药提取有效成分制备成为本发明产品。
实施例2：一种实施例1中治疗带状疱疹神经痛的外敷药的制备方法，按实施例1中所述重量份称取各组分原料药，将两面针、七叶一枝花、连翘、苦参、夏枯草、板蓝根、山慈菇、五倍子、红大戟、生甘草和黑豆粉碎，加入75％乙醇1500份，加热回流提取3次，每次半小时，合并提取液后减压浓缩至无醇味，放置至温度降为常温；将雄黄、麝香、薄荷、冰片、千金子霜、阿魏酸钠、阿昔洛韦、维生素C和维生素B12均研细制为细粉，将细粉与浓缩提取液混匀；加入蒸馏水调节相对密度至1.1mg/ml-1.2mg/ml范围内；以γ射线辐照灭菌即得。

Claims (2)

1.一种治疗带状疱疹神经痛的外敷药，其特征在于：由以下重量份原料药中的提取成分制成：两面针30份、七叶一枝花60份，薄荷9份，冰片9份，连翘30份，苦参50份，夏枯草40份，板蓝根30份，生甘草20份，黑豆30份，山慈姑60份，红大戟45份，千金子霜30份，五倍子30份，麝香9份，雄黄6份，阿魏酸钠1份，阿昔洛韦1份，维生素C10份，维生素B120.005份。
2.一种权利要求1中所述的治疗带状疱疹神经痛的外敷药的制备方法，其特征在于：按权利要求1中所述重量份称取各组分原料药，将两面针、七叶一枝花、连翘、苦参、夏枯草、板蓝根、山慈菇、五倍子、红大戟、生甘草和黑豆粉碎，加入75％乙醇1500份，加热回流提取3次，每次半小时，合并提取液后减压浓缩至无醇味，放置至温度降为常温；将雄黄、麝香、薄荷、冰片、千金子霜、阿魏酸钠、阿昔洛韦、维生素C和维生素B12均研细制为细粉，将细粉与浓缩提取液混匀；加入蒸馏水调节相对密度至1.1mg/ml-1.2mg/ml范围内；以γ射线辐照灭菌即得。
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