CN105412308A - Traditional Chinese medicinal preparation for treating atrophic gastritis - Google Patents

Abstract

The invention discloses a traditional Chinese medicinal preparation for treating atrophic gastritis. The traditional Chinese medicinal preparation is prepared from the following active pharmaceutical ingredients: 15 parts of radix bupleuri, 15 parts of white paeony root, 10 parts of honey-fried licorice root, 15 parts of rhizome of large-headed atractylode, 15 parts of platycodon grandiflorum, 15 parts of cynanchum paniculatum, 15 parts of fructus forsythiae, 15 parts of radix aconiti lateralis preparata, 15 parts of rhizoma corydalis, 20 parts of dried orange peel, 15 parts of inula flower, 10 parts of dark plum, 15 parts of fructus trichosanthis, 15 parts of hairyvein agrimony and 15 parts of pseudo-ginseng. The selected active pharmaceutical ingredients complement each other in medicinal effects, so that medicinal effects of weakening, inhibition or elimination and elimination of toxic reaction or side effects among medicines are avoided, remarkable matching and assisting actions of the medicines are obtained, and the effect of improving the immunity is realized; the aims of warming the middle-jiao and strengthening the spleen, soothing liver-qi stagnation and diminishing inflammation and relieving pain in treatment are achieved; the traditional Chinese medicinal preparation is internally taken to realize definite curative effects for the atrophic gastritis, spleen deficiency and burnout.

Description

The Chinese medicine preparation for the treatment of atrophic gastritis

Technical field

The present invention relates to a kind of field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of atrophic gastritis, there is effect of warming middle-JIAO and strengthening the spleen, dispersing the stagnated live-QI to relieve the stagnation of QI, anti-inflammatory analgetic, for atrophic gastritis, insufficiency of the spleen, asthenia successful.

Background technology

Atrophic gastritis also claims chronic atrophic gastritis, and with gastric epithelial and body of gland atrophy, decreased number, gastric mucosa is thinning, and mucosa basic unit thickens, or companion's gland metaplasia and intestinal gland metaplasia, or has atypical hyperplasia to be the chronic digestive system disease of feature.Often show as epigastrium dull pain, distension, belch, inappetence, or become thin, anemia etc., without specificity.The clinical manifestation of atrophic gastritis not only lacks specificity, and not quite identical with lesion degree.Clinical manifestation below normal appearance: gastral cavilty portion distension; Gastral cavilty portion pain; Heartburn and indigestion symptom; Stool abnormity and weakness symptom; Anemia.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of atrophic gastritis, there is effect of warming middle-JIAO and strengthening the spleen, dispersing the stagnated live-QI to relieve the stagnation of QI, anti-inflammatory analgetic, for atrophic gastritis, insufficiency of the spleen, asthenia successful.

The technical solution used in the present invention is:

The Chinese medicine preparation of described treatment atrophic gastritis, the raw medicinal material of employing respectively: Radix Bupleuri 15 parts, the Radix Paeoniae Alba 15 parts, Radix Glycyrrhizae Preparata 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Platycodonis 15 parts, Radix Cynanchi Paniculati 15 parts, Fructus Forsythiae 15 parts, Radix Aconiti Lateralis Preparata 15 parts, Rhizoma Corydalis 15 parts, Pericarpium Citri Reticulatae 20 parts, Flos Inulae 15 parts, Fructus Mume 10 parts, Fructus Trichosanthis 15 parts, Herba Agrimoniae 15 parts, Radix Notoginseng 15 parts.

Its preparation method is following steps: step one), weighting raw materials material Radix Bupleuri 15 parts, the Radix Paeoniae Alba 15 parts, Radix Glycyrrhizae Preparata 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Platycodonis 15 parts, Radix Cynanchi Paniculati 15 parts, Fructus Forsythiae 15 parts, Radix Aconiti Lateralis Preparata 15 parts, Rhizoma Corydalis 15 parts, Pericarpium Citri Reticulatae 20 parts, Flos Inulae 15 parts, Fructus Mume 10 parts, Fructus Trichosanthis 15 parts, Herba Agrimoniae 15 parts, Radix Notoginseng 15 parts, remove impurity, eluriate rapidly with cold boiled water water, drain water liquid, dry;

Step 2), step one) raw medicinal material that obtains makes decoction pieces respectively, puts in suitable decocting device, it is appropriate to add clear water, soaks suitable time, is heated to boil, keep slight boiling condition certain hour (about 0.5 ~ 1 hour), be separated fried liquid;

Step 3), step 2) obtain the medicinal residues after filtering and to add water again appropriate decoction, after regulation decoction 2 ~ 3 times, merge fried liquid, filtration or settlement separate fried liquid;

Step 4), step 3) Chinese medicine preparation that obtains packs, and obtains commodity Chinese medicine preparation.

In the raw medicinal material that the present invention chooses, its effect and pharmacological action respectively:

Radix Codonopsis: there is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.Meridian distribution of property and flavor: property is put down, sweet in the mouth, micro-acid.Return spleen, lung meridian.Chemical composition: Radix Codonopsis is containing triterpenoid compound freidelin (friedelin), alnulin acetas, bessisterol and glycoside thereof, △ 7-stigmastenol and glycoside, spinach sterone (spinesterone).Another containing atractyloide III (atractylenolide III), atractyloide II (atractylenolide II), syringic aldehyde (syringaldehyde), Syringin (syringin), vanillic acid (vanillicacid), 5-hydroxyl-2-piconol (5-hydroxy-2-pyridinemethanol), α-furyl carboxylic acid (α-furancarboxylicacid), n-hexyl-glycoside (n-hexyl-β-D-glucopyranoside), ethyl-α-D-fructofuranoside (ethyl-α-D-fructofuranoside), and nicotinic acid, 4 kinds of heteropolysaccharide and monosaccharide etc.Still containing tangshenoside Ⅰ, codonolactone and codopiloic acid.

Poria: property slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.

Pericarpium Citri Reticulatae: Pericarpium Citri Reticulatae contains hesperidin about 8.4%, Nobiletin (nobiletin) about 0.15%. separately containing Neosynephrine (oxedrine) 0.28%-2.54%。[nature and flavor] are bitter, pungent, temperature.[return through] returns lung, spleen channel.[attending effectiveness]: regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool.Phlegm-damp stops up the cough and asthma of lung.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

The Rhizoma Pinelliae: the pungent loose warm-dryness syndrome of these product is poisonous, main enter taste double enter lung, water of manageing it wets, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.Water is wet to be gone, and the strong and sputum of spleen is from disappearing, and inverse gas falls then harmonization of the stomach and feeling of fullness vomiting from only, therefore is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.Both cured mainly the abundant expectoration cough with asthma QI rising in reverse order of spleen damp-phlegm heap soil or fertilizer over and around the roots, and as ERCHEN TANG, XIAOQINGLONG TANG, controlled again the dizzy palpitation and insomnia that damp-phlegm is violated, and as banxia baizhu tianma decoction, also can control wind-phlegm and tell inverse, headache limb fiber crops, hemiplegia, the diseases such as facial hemiparalysis, as beautiful kettle ball.

Fructus Amomi: nature and flavor: acrid in the mouth, warm in nature.Gui Jing: return spleen channel, stomach warp, kidney channel.Function: removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.Cure mainly: for turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.

Cortex Magnoliae Officinalis: nature and flavor: bitter; Pungent; Warm in nature.Gui Jing: spleen channel; Stomach warp; Large intestine channel.Function: circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Cure mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant stops up QI rising in reverse order; Fullness in the chest is breathed with cough.

The Radix Linderae: effect: 1, the excitation of volatile oil: time for oral administration, have excited corticocerebral effect, and have promotion to breathe, excited cardiac muscle, accelerates blood circulation, the effect of raising blood pressure and diaphoresis.Local topical makes local vascular dilation, and blood circulation accelerates, and relaxes muscle spasm pain.2, bacteriostasis: to staphylococcus aureus, α-hemolytic streptococcus, Bacillus typhi, Bacillus proteus, bacillus pyocyaneus, escherichia coli all have inhibitory action.3, on gastral impact: have the report Radix Linderae to have dual function to gastrointestinal smooth muscle, in addition, the Radix Linderae can increase the secretion of Digestive system.4, anastalsis: experiment in vitro proves, Radix Linderae dry powder can obviously shorten plasma in rabbit recalcification time, promotes blood clotting and good anastalsis.5, other effect: feed rat for a long time with the Radix Linderae, body weight can be made to increase, and have inhibitory action to murine sarcoma-180.Its Borneolum Syntheticum can diaphoresis, excitement, spasmolytic, anthelmintic etc.

Flos Caryophylli: have warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Warming middle-JIAO to send down the adverse QI; The function of warming the kidney to activate YANG.Cure mainly: control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.

Rhizoma Zingiberis: [nature and flavor, return through] acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian.[effect] warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.[curing mainly] coldness and pain in the epigastrium; Vomiting; Have loose bowels, YANG-depletion is fainted inverse; Cold fluid-retention is breathed with cough; Arthralgia due to cold-dampnes.

Fructus Crataegi: slightly warm in nature, sour in the mouth is sweet, enters spleen, stomach, Liver Channel, has the function of promoting digestion and invigorating the stomach, activating blood circulation to dissipate blood stasis, convergence dysentery relieving.To meat amass phlegm retention, feeling of fullness acid regurgitation, dysentery hemorrhoidal hamorrhage, lumbago hernia, puerperal after-pains, lochiorrhea, children's breast food stagnate etc., all effective in cure.Fructus Crataegi energy prevention and cure of cardiovascular disease, has blood vessel dilating, heart tonifying, increase coronary flow, improves heart vigor, stimulating central nervous system system, reduces blood pressure and cholesterol, vessel softening and diuresis and sedation; Prevent and treat arteriosclerosis, anti-aging, anticancer effect.Crataegolic acid also has cardiotonic, also benefits to senile heart disease.Appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, circulation of qi promoting of reducing phlegm.For meat stagnant long-pending, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.

Massa Medicata Fermentata: nature and flavor: sweet, acrid, warm.Gui Jing: return spleen, stomach warp.Effect: invigorating the spleen and regulating the stomach, promoting digestion and removing stagnation.Cure mainly: for retention of food and drink, dyspepsia, distension and fullness in the abdomen, inappetence, vomiting dysentery.

Fructus Hordei Germinatus: promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back newborn relieving distension.Do not disappear for food stagnation, abdominal distention, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders, distending pain of the breast, and women weans, Fructus Hordei Germinatus invigorating the spleen and regulating the stomach lactogenesis.For insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders.The galactopoiesis of Fructus Hordei Germinatus (parched) promote qi circulation digestion promoting.Do not disappear for food stagnation, women weans.Fructus Hordei Germinatus (parched to brown) relieving dyspepsia.Do not disappear for food stagnation, abdominal distention.Main warming the middle warmer and descending qi, appetite promoting and the spleen strengthening, expedites the emergence of lower tire, and change dyspepsia, except distension, emesis is inverse, broken note of the ancient Chinese, expectorant painful abdominal mass.Digestion-aid effect: this product is containing α and beta amylase.And starch is the mixture of amylose and amylopectin.The glucose molecule of composition amylose is connected with α-Isosorbide-5-Nitrae glycoside key, and the arrangement in straight chain.Amylopectin is by several short straight chain polyglucose cross arrangements.Except α-Isosorbide-5-Nitrae glycoside key, α-1,6 glycoside key is also had in branched amylopectin molecules.α and beta amylase hydrolyzable α-Isosorbide-5-Nitrae glycoside key, to α-1,6 glycoside key without effect.Amylose complete hydrolysis can be become maltose by beta amylase, and alpha amylase then makes it to resolve into short straight key polyglucose (i.e. dextrin), and the latter can again for beta amylase be hydrolyzed into maltose.Therefore starch is decomposed into maltose and dextrin under the effect of α and beta amylase.Fructus Hordei Germinatus decoct seemingly has slight facilitation to gastric acid and pepsic secretion.

Radix Glycyrrhizae: property is put down, sweet in the mouth.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Chemical composition: Radix Glycyrrhizae contains number of chemical composition, and main component has glycyrrhizic acid, liquiritin etc.From Radix Glycyrrhizae, isolated compound has the tens of kinds of compounds such as glycyrrhizin, enoxolone, liquiritin, isoliquiritin, neoliquriitin, neoisoliquiritin, glycyrrhizin, isoliquiritigenin and licoricidin (+)-Licoricidin., glycyrol, isoglycyrol, 7-methylcoumarin essence, umbelliferone.

Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.[function with cure mainly] blood-activating and qi-promoting, wind-expelling pain-stopping.For pacifying nerve, positive wind syndrome of head headache, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Complementary with the raw medicinal material property of medicine effect selected by top, evade the choosing of the mutual inhibition of compatibility between medicine, mutual restraint between two drugs, the mutual-detoxication, made medicine mutual reinforcement between, mutual-assistance effect significantly, there is raising immunity.Treatment can reach the object of warming middle-JIAO and strengthening the spleen, dispersing the stagnated live-QI to relieve the stagnation of QI, anti-inflammatory analgetic.For oral administration have definite curative effect to atrophic gastritis, insufficiency of the spleen, asthenia.Effect of Chinese medicine preparation of the present invention obtains confirmation in the middle of clinical practice, clinical test of pesticide effectiveness material and model case:

1. an XX, man, 43 years old.Stomach dull pain, time light time heavy more than 5 years, once took multiple Chinese medicine and western medicine, do not heal always, within nearly 1 month, increased the weight of.Just examine: indistinctly, dryness of the mouth and throat, drinks yearningly and not, and appetite decrescence, is done swollen after food in stomachache, eat pungent product pain very, dizzy weak, two dryness and uneasy feeling of the eye, blurring of vision, dysphoria with feverish sensation in the chest palms and soles, shallow complexion, red and uncoated tongue, thready and rapid pulse.Gastropathy with the passing of time, hindered by stomach-Yin, and lose in moistening foster, the stagnation of QI is had a pain.Control with warming middle-JIAO and strengthening the spleen, dispersing the stagnated live-QI to relieve the stagnation of QI, anti-inflammatory analgetic method.After clothes we 10 doses, stomachache stops, and all disease knowing subtract, only dry stool, feverish sensation in the palms and soles.After continuing to take we 25 doses, transference cure, recovers.

Method and effective dose: Radix Bupleuri 15 parts, the Radix Paeoniae Alba 15 parts, Radix Glycyrrhizae Preparata 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Platycodonis 15 parts, Radix Cynanchi Paniculati 15 parts, Fructus Forsythiae 15 parts, Radix Aconiti Lateralis Preparata 15 parts, Rhizoma Corydalis 15 parts, Pericarpium Citri Reticulatae 20 parts, Flos Inulae 15 parts, Fructus Mume 10 parts, Fructus Trichosanthis 15 parts, Herba Agrimoniae 15 parts, Radix Notoginseng 15 parts.

Its preparation method is following steps: step one), weighting raw materials material Radix Bupleuri 15 parts, the Radix Paeoniae Alba 15 parts, Radix Glycyrrhizae Preparata 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Platycodonis 15 parts, Radix Cynanchi Paniculati 15 parts, Fructus Forsythiae 15 parts, Radix Aconiti Lateralis Preparata 15 parts, Rhizoma Corydalis 15 parts, Pericarpium Citri Reticulatae 20 parts, Flos Inulae 15 parts, Fructus Mume 10 parts, Fructus Trichosanthis 15 parts, Herba Agrimoniae 15 parts, Radix Notoginseng 15 parts, remove impurity, eluriate rapidly with cold boiled water water, drain water liquid, dry;

Step 2), step one) raw medicinal material that obtains makes decoction pieces respectively, puts in suitable decocting device, it is appropriate to add clear water, soaks suitable time, is heated to boil, keep slight boiling condition certain hour (about 0.5 ~ 1 hour), be separated fried liquid;

Step 3), step 2) obtain the medicinal residues after filtering and to add water again appropriate decoction, after regulation decoction 2 ~ 3 times, merge fried liquid, filtration or settlement separate fried liquid;

Step 4), step 3) Chinese medicine preparation that obtains packs, and obtains commodity Chinese medicine preparation.

Decoction oral is main, every day 1 dose, is decocted in water for oral dose, and sooner or later respectively takes 1 time, each 100ml decoction being taken warmly.

Detailed description of the invention

The Chinese medicine preparation of described treatment atrophic gastritis, the raw medicinal material of employing respectively: Radix Bupleuri 15 parts, the Radix Paeoniae Alba 15 parts, Radix Glycyrrhizae Preparata 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Platycodonis 15 parts, Radix Cynanchi Paniculati 15 parts, Fructus Forsythiae 15 parts, Radix Aconiti Lateralis Preparata 15 parts, Rhizoma Corydalis 15 parts, Pericarpium Citri Reticulatae 20 parts, Flos Inulae 15 parts, Fructus Mume 10 parts, Fructus Trichosanthis 15 parts, Herba Agrimoniae 15 parts, Radix Notoginseng 15 parts.

Its preparation method is following steps: step one), weighting raw materials material Radix Bupleuri 15 parts, the Radix Paeoniae Alba 15 parts, Radix Glycyrrhizae Preparata 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Platycodonis 15 parts, Radix Cynanchi Paniculati 15 parts, Fructus Forsythiae 15 parts, Radix Aconiti Lateralis Preparata 15 parts, Rhizoma Corydalis 15 parts, Pericarpium Citri Reticulatae 20 parts, Flos Inulae 15 parts, Fructus Mume 10 parts, Fructus Trichosanthis 15 parts, Herba Agrimoniae 15 parts, Radix Notoginseng 15 parts, remove impurity, eluriate rapidly with cold boiled water water, drain water liquid, dry;

Step 2), step one) raw medicinal material that obtains makes decoction pieces respectively, puts in suitable decocting device, it is appropriate to add clear water, soaks suitable time, is heated to boil, keep slight boiling condition certain hour (about 0.5 ~ 1 hour), be separated fried liquid;

Step 3), step 2) obtain the medicinal residues after filtering and to add water again appropriate decoction, after regulation decoction 2 ~ 3 times, merge fried liquid, filtration or settlement separate fried liquid;

Step 4), step 3) Chinese medicine preparation that obtains packs, and obtains commodity Chinese medicine preparation.

Claims (2)

1. the Chinese medicine preparation of a described treatment atrophic gastritis, it is characterized in that, the raw medicinal material of employing respectively: Radix Bupleuri 15 parts, the Radix Paeoniae Alba 15 parts, Radix Glycyrrhizae Preparata 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Platycodonis 15 parts, Radix Cynanchi Paniculati 15 parts, Fructus Forsythiae 15 parts, Radix Aconiti Lateralis Preparata 15 parts, Rhizoma Corydalis 15 parts, Pericarpium Citri Reticulatae 20 parts, Flos Inulae 15 parts, Fructus Mume 10 parts, Fructus Trichosanthis 15 parts, Herba Agrimoniae 15 parts, Radix Notoginseng 15 parts.

2. the Chinese medicine preparation for the treatment of atrophic gastritis according to claim 1, it is characterized in that: its preparation method, preparation method is following steps: step one), weighting raw materials material Radix Bupleuri 15 parts, the Radix Paeoniae Alba 15 parts, Radix Glycyrrhizae Preparata 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Platycodonis 15 parts, Radix Cynanchi Paniculati 15 parts, Fructus Forsythiae 15 parts, Radix Aconiti Lateralis Preparata 15 parts, Rhizoma Corydalis 15 parts, Pericarpium Citri Reticulatae 20 parts, Flos Inulae 15 parts, Fructus Mume 10 parts, Fructus Trichosanthis 15 parts, Herba Agrimoniae 15 parts, Radix Notoginseng 15 parts, remove impurity, eluriate rapidly with cold boiled water water, drain water liquid, dry;

Step 2), step one) raw medicinal material that obtains makes decoction pieces respectively, puts in suitable decocting device, it is appropriate to add clear water, soaks suitable time, is heated to boil, keep slight boiling condition certain hour (about 0.5 ~ 1 hour), be separated fried liquid;

Step 3), step 2) obtain the medicinal residues after filtering and to add water again appropriate decoction, after regulation decoction 2 ~ 3 times, merge fried liquid, filtration or settlement separate fried liquid;

Step 4), step 3) Chinese medicine preparation that obtains packs, and obtains commodity Chinese medicine preparation.