CN105412271A - Composition for improving sleep and preparation method thereof - Google Patents
Composition for improving sleep and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention provides a composition for improving sleep and preparation method thereof. The composition is prepared from, by weight, 10-60 parts of golden silk jujube extract, 10-45 parts of spina date seed extract and 10-45 parts of multiflower knotweed vine extract in a mixing mode. Components of the compositions have synergistic effect, and the sleep improvement effect is remarkable; the composition is free of side effect, good to taste, easy to absorb and convenient to take; besides, the composition is simple in preparation method, convenient to use and suitable for the requirement of large-scale industrial production.
Description
Technical field
The present invention relates to field of health care food, especially a kind of composition and method of making the same for improving water flood.
Background technology
Sleep is the important physiological process of human life, and the time of 1/3rd that has in life of people will be spent in sleep.Good sleep is the guarantee obtaining height labor efficiency, is also to preserve one's strength and healthy basis.Along with rhythm of life quickening, operating pressure increase, occur that crowd's quantity of sleep disorder is in continuous expansion, extended sleep is not enough, and sleep quality is not high, not only reduces quality of life, affects work efficiency, also can increase accident potential and the ill danger of mental sickness.
Be necessary so develop a health food with improving water flood function.The health food of more existing improving water flood in the market, but effect is general.Therefore, based on theory of Chinese medical science, in conjunction with modern medicine, develop formula rationally, the significant health food of improving water flood effect has very important using value.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of compositions for improving water flood.
Another technical problem to be solved by this invention is the preparation method providing the above-mentioned compositions for improving water flood.
For solving the problems of the technologies described above, technical scheme of the present invention is:
For a compositions for improving water flood, be made up of Golden jujube extracting solution, Semen Ziziphi Spinosae extracting solution fleece-flower root rattan extracting solution, by its weight parts Golden jujube extracting solution 10 ~ 60 parts, Semen Ziziphi Spinosae extracting solution 10 ~ 45 parts, Caulis Polygoni Multiflori extracting solution 10 ~ 45 parts.
Preferably, the above-mentioned compositions for improving water flood, by its weight parts Golden jujube extracting solution 20 ~ 50 parts, Semen Ziziphi Spinosae extracting solution 15 ~ 40 parts, Caulis Polygoni Multiflori extracting solution 15 ~ 40 parts.
Preferably, the above-mentioned compositions for improving water flood, by its weight parts Golden jujube extracting solution 30 parts, Semen Ziziphi Spinosae extracting solution 25 parts, Caulis Polygoni Multiflori extracting solution 25 parts.
Preferably, the above-mentioned compositions for improving water flood, be made up of Golden jujube extracting solution, Semen Ziziphi Spinosae extracting solution, Caulis Polygoni Multiflori extracting solution and γ-aminobutyric acid, by its weight parts Golden jujube extracting solution 30 ~ 45 parts, Semen Ziziphi Spinosae extracting solution 15 ~ 30 parts, Caulis Polygoni Multiflori extracting solution 15 ~ 30 parts, γ-aminobutyric acid 0.2 ~ 2 part.
Preferably, the above-mentioned compositions for improving water flood, by its weight parts Golden jujube extracting solution 37.5 parts, Semen Ziziphi Spinosae extracting solution 28 parts, Caulis Polygoni Multiflori extracting solution 23 parts, γ-aminobutyric acid 1.8 parts.
The preparation method of the above-mentioned compositions for improving water flood, concrete steps are as follows:
(1) Semen Ziziphi Spinosae fleece-flower root rattan extracting solution preparation: take broken Semen Ziziphi Spinosae and the Caulis Polygoni Multiflori of cutting, add the gross weight 6-15 times of purification hydration of Semen Ziziphi Spinosae fleece-flower root rattan to carry, micro-steaming and decocting 0.5-5h that boils, extracts 2-3 time, merge extractive liquid, concentrating under reduced pressure, through ethanol precipitate with ethanol, get supernatant, decompression is except ethanol, concentrated, be settled to 0.5-3 times of weight of medical material amount;
(2) Golden jujube extracting solution preparation: Golden jujube is through cleaning, removing the peel enucleation, fragmentation, adding Golden jujube gross weight 5-12 times purified water, 40-90 DEG C of lixiviate 1-10h, then be incubated at 20-50 DEG C, enzymolysis 1-6h is carried out by pectase and cellulase, the addition of described pectase and cellulase is the 0.01-0.1% (V/V) of solution total amount, filtration, sterilizing preparation;
(3) by the mixing of prescription amount, filtration, fill: by said extracted liquid mix homogeneously, fill after filtering;
(4) sterilizing: temperature 100-120 DEG C, time 10-60min.
Preferably, the preparation method of the above-mentioned compositions for improving water flood, taking γ-aminobutyric acid is dissolved in its gross weight 5-20 times purified water, be stirred well to and dissolve completely, then mix homogeneously with step (1), (2) gained extracting solution by prescription amount according to above-mentioned steps (3), fill after filtering.
In the preparation method of the above-mentioned compositions for improving water flood, each prescription can also add the adjuvant of weight portion below according to needs of production: mucilage 0.1 ~ 10 part, aromatic 0.0005 ~ 0.01 part, wherein, described mucilage is preferably sodium carboxymethyl cellulose or xanthan gum, and described aromatic is preferably Fructus Jujubae taste essence or Ziziphi Spinosae taste essence.
The above-mentioned usage and dosage with compositions for improving water flood: every day 10-50ml.
The invention has the beneficial effects as follows:
The above-mentioned compositions for improving water flood, each prescription Synergistic, improving water flood effect is remarkable, have no side effect, and mouthfeel is good, easily absorbs, is convenient to take; Its preparation method is simple, easy to use, is applicable to the needs that large-scale industrial is produced.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
For a compositions for improving water flood, be made up of Golden jujube extracting solution, Semen Ziziphi Spinosae extracting solution fleece-flower root rattan extracting solution, concrete consumption is in table 1.Preparation method is as follows:
(1) Semen Ziziphi Spinosae fleece-flower root rattan extracting solution preparation: take broken Semen Ziziphi Spinosae and the Caulis Polygoni Multiflori of cutting, add 10 times of purification hydrations to carry, micro-steaming and decocting 3h that boils, extracts 3 times, merge extractive liquid, concentrating under reduced pressure, through ethanol precipitate with ethanol, get supernatant, decompression is except ethanol, concentrated, be settled to 1.5 times of weight of medical material amount;
(2) Golden jujube extracting solution preparation: Golden jujube is through cleaning, removing the peel enucleation, fragmentation, adding 8 times of purified water, 70 DEG C of lixiviate 6h, then be incubated at 35 DEG C, enzymolysis 4h is carried out by pectase and cellulase, the addition of described pectase and cellulase is 0.05% (V/V) of solution total amount, filtration, sterilizing preparation;
(3) by the mixing of prescription amount, filtration, fill: by said extracted liquid mix homogeneously, fill after filtering;
(4) sterilizing: temperature 110 DEG C, time 30min.
Table 1
| Embodiment | Golden jujube extracting solution (kg) | Semen Ziziphi Spinosae extracting solution (kg) | Caulis Polygoni Multiflori extracting solution (kg) |
| 1-1 | 30 | 25 | 25 |
| 1-2 | 20 | 15 | 35 |
| 1-3 | 40 | 35 | 15 |
| 1-4 | 50 | 10 | 40 |
| 1-5 | 60 | 40 | 10 |
| 1-6 | 10 | 45 | 45 |
Embodiment 2
For a compositions for improving water flood, be made up of Golden jujube extracting solution, Semen Ziziphi Spinosae extracting solution, Caulis Polygoni Multiflori extracting solution and γ-aminobutyric acid, concrete consumption is in table 2.Preparation method is as follows:
(1) Semen Ziziphi Spinosae fleece-flower root rattan extracting solution preparation: take broken Semen Ziziphi Spinosae and the Caulis Polygoni Multiflori of cutting, add 12 times of purification hydrations to carry, micro-steaming and decocting 4h that boils, extracts 3 times, merge extractive liquid, concentrating under reduced pressure, through ethanol precipitate with ethanol, get supernatant, decompression is except ethanol, concentrated, be settled to 2 times of weight of medical material amount;
(2) Golden jujube extracting solution preparation: Golden jujube is through cleaning, removing the peel enucleation, fragmentation, adding Golden jujube gross weight 10 times of purified water, 80 DEG C of lixiviate 8h, then be incubated at 40 DEG C, enzymolysis 5h is carried out by pectase and cellulase, the addition of described pectase and cellulase is 0.08% (V/V) of solution total amount, filtration, sterilizing preparation;
(3) γ-aminobutyric acid taken is dissolved in 10 times of purified water, is stirred well to and dissolves completely;
(4) by the mixing of prescription amount, filtration, fill: by said extracted liquid mix homogeneously, fill after filtering;
(5) sterilizing: temperature 120 DEG C, time 30min.
Table 2
Efficacy experiments 1
1. materials and methods:
1.1 laboratory animals:
Healthy ICR kind mice, body weight 18 ~ 22g, is provided by Laboratory Animal Science portion of Department Of Medicine, Peking University.
1.2 dosage and grouping:
Every experiment animal used is all divided into 4 groups at random by body weight, often organize 15, if blank group and basic, normal, high three dosage groups, distinguish compositions 0.0167mL/10g.bw, 0.0333mL/10g.bw, 0.1000mL/10g.bw described in gavage distilled water and embodiment of the present invention 1-1, continuous 30 days.
1.3 experimental techniques:
Test according to health food inspection and assessment technical specification (2003 editions).
1.4 statistical analysis techniques:
One factor analysis of variance is carried out and χ 2 analyzes with SPSS software.
2. result
2.1 direct sleep experiments
After each dosage treated animal gives corresponding given the test agent, take righting reflex loss as sleep, revert to awakening with righting reflex, righting reflex loss is the animal sleep time to recovering during this period of time, record sleep number of animals and the length of one's sleep.Result is as follows:
Table 3: given the test agent is on the impact (n=15) of directly sleep
| Group | Number of animals (only) | Sleep number of animals (only) | Animal sleep rate (%) |
| Blank | 15 | 0 | 0 |
| Low dose group | 15 | 0 | 0 |
| Middle dosage group | 15 | 0 | 0 |
| High dose group | 15 | 0 | 0 |
All there is not phenomenon of sleeping after each group of mouse stomach, show to act on without direct sleep.
2.2 extend the pentobarbital sodium experiment length of one's sleep
Animal last awards solvent and variable concentrations given the test agent 15min pneumoretroperitoneum injection pentobarbital sodium 48mg/kgbw, take righting reflex loss as index, record pentobarbital sodium length of one's sleep.Experimental result is as follows:
Table 4: given the test agent extends the impact (x ± s) of the length of one's sleep to pentobarbital sodium
| Group | Number of animals (only) | The length of one's sleep (min) |
| Blank | 14 | 48.51±13.30 |
| Low dose group | 15 | 75.92±23.22** |
| Middle dosage group | 14 | 89.20±21.34** |
| High dose group | 15 | 92.51±20.72**,# |
* represents that comparing p < 0.01, # represents and compare p < 0.05 with blank group with low dose group
Experimental result shows, the each dosage group of compositions described in embodiment of the present invention 1-1 contrasts with blank group, mouse sleep time extremely significantly increases (p < 0.01), and present certain dosage effect, wherein low, high dose group has significant difference the length of one's sleep, show that the length of one's sleep to extending injection pentobarbital sodium mice has facilitation, experimental result is positive.
2.3 pentobarbital sodium sub-threshold dose hypnosis experiments
Animal last awards solvent and variable concentrations given the test agent 15min pneumoretroperitoneum injection pentobarbital sodium 28mg/kgbw, is sleep standard with more than righting reflex loss 1min, each group sleep mice number in record 30min.Experimental result is as follows:
Table 5: given the test agent is on the impact of pentobarbital sodium sub-threshold dose syngignoscism
| Group | Number of animals (only) | Sleep number of animals (only) | Animal sleep rate (%) |
| Blank group | 15 | 2 | 13.33 |
| Low dose group | 14 | 6 | 42.85 |
| Middle dosage group | 14 | 7 | 50.00* |
| High dose group | 15 | 8 | 53.33* |
* represent and compare p < 0.05 with blank group
As can be seen from experimental result, the sleep incidence rate of the basic, normal, high dosage group of compositions described in embodiment of the present invention 1-1 is all higher than blank group, and wherein middle and high dosage group sleep incidence rate is significantly higher than blank group.Along with the increase of tested material dosage, sleep incidence rate increases gradually, but there was no significant difference between each dosage group.These results suggest that, compositions described in embodiment of the present invention 1-1 and pentobarbital sodium have synergism, and sub-threshold dose hypnosis experimental result is positive.
2.4 barbital sodium Sleep latency experiments
Animal last awards 15min, lumbar injection barbital sodium 300mg/kgbw after solvent and variable concentrations given the test agent, is index, records each treated animal Sleep latency with righting reflex loss.Experimental result is as follows:
Table 6: given the test agent is on the impact (x ± s) of barbital sodium Sleep latency
| Group | Number of animals (only) | Incubation period (min) |
| Blank | 15 | 33.39±7.28 |
| Low dose group | 15 | 29.11±8.39 |
| Middle dosage group | 15 | 23.91±7.07** |
| High dose group | 15 | 23.24±7.30**,# |
* represents that comparing p < 0.01, # represents and compare p < 0.05 with blank group with low dose group
Experimental result shows, and in compositions described in embodiment of the present invention 1-1, high dose group Sleep latency extremely significantly reduces compared with blank group, and high dose and low dose group significant difference, each dosage group presents certain dose-effect relationship.Experimental result is positive.
3 check conclusions:
In sum, compositions described in embodiment of the present invention 1-1 acts on without direct sleep, the experiment length of one's sleep of prolongation pentobarbital sodium, pentobarbital sodium sub-threshold dose hypnosis experiment, barbital sodium Sleep latency experimental result are all positive, according to health food inspection and assessment method (2003 editions), compositions of the present invention has improving water flood function.
Compositions described in embodiment of the present invention 2-1 is adopted to carry out above-mentioned experiment, experimental result shows described compositions equally and acts on without direct sleep, the experiment length of one's sleep of prolongation pentobarbital sodium, pentobarbital sodium sub-threshold dose hypnosis experiment, barbital sodium Sleep latency experimental result are all positive, and specific experiment the results are shown in following table:
Table 7: given the test agent is on the impact (n=15) of directly sleep
| Group | Number of animals (only) | Sleep number of animals (only) | Animal sleep rate (%) |
| Blank | 15 | 0 | 0 |
| Low dose group | 15 | 0 | 0 |
| Middle dosage group | 15 | 0 | 0 |
| High dose group | 15 | 0 | 0 |
All there is not phenomenon of sleeping after each group of mouse stomach, show to act on without direct sleep.
Table 8: given the test agent extends the impact (x ± s) of the length of one's sleep to pentobarbital sodium
| Group | Number of animals (only) | The length of one's sleep (min) |
| Blank | 15 | 48.07±14.20 |
| Low dose group | 14 | 77.13±21.35** |
| Middle dosage group | 15 | 91.78±20.64**,# |
| High dose group | 15 | 95.39±22.01**,# |
* represents that comparing p < 0.01, # represents and compare p < 0.05 with blank group with low dose group
Table 9: given the test agent is on the impact of pentobarbital sodium sub-threshold dose syngignoscism
| Group | Number of animals (only) | Sleep number of animals (only) | Animal sleep rate (%) |
| Blank group | 15 | 2 | 13.33 |
| Low dose group | 15 | 7 | 46.67 |
| Middle dosage group | 15 | 8 | 53.33* |
| High dose group | 15 | 9 | 60.00* |
* represent and compare p < 0.05 with blank group
Table 10: given the test agent is on the impact (x ± s) of barbital sodium Sleep latency
| Group | Number of animals (only) | Incubation period (min) |
| Blank | 15 | 34.31±7.29 |
| Low dose group | 15 | 29.27±7.20 |
| Middle dosage group | 14 | 21.03±6.40** |
| High dose group | 15 | 19.71±6.76**,# |
* represents that comparing p < 0.01, # represents and compare p < 0.05 with blank group with low dose group
Above-mentioned detailed description of a kind of composition and method of making the same for improving water flood of the present invention being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (7)
1. the compositions for improving water flood, it is characterized in that: be made up of Golden jujube extracting solution, Semen Ziziphi Spinosae extracting solution fleece-flower root rattan extracting solution, by its weight parts Golden jujube extracting solution 10 ~ 60 parts, Semen Ziziphi Spinosae extracting solution 10 ~ 45 parts, Caulis Polygoni Multiflori extracting solution 10 ~ 45 parts.
2. the compositions for improving water flood according to claim 1, is characterized in that: by its weight parts Golden jujube extracting solution 20 ~ 50 parts, Semen Ziziphi Spinosae extracting solution 15 ~ 40 parts, Caulis Polygoni Multiflori extracting solution 15 ~ 40 parts.
3. the compositions for improving water flood according to claim 2, is characterized in that: by its weight parts Golden jujube extracting solution 30 parts, Semen Ziziphi Spinosae extracting solution 25 parts, Caulis Polygoni Multiflori extracting solution 25 parts.
4. the compositions for improving water flood according to claim 1, it is characterized in that: be made up of Golden jujube extracting solution, Semen Ziziphi Spinosae extracting solution, Caulis Polygoni Multiflori extracting solution and γ-aminobutyric acid, by its weight parts Golden jujube extracting solution 30 ~ 45 parts, Semen Ziziphi Spinosae extracting solution 15 ~ 30 parts, Caulis Polygoni Multiflori extracting solution 15 ~ 30 parts, γ-aminobutyric acid 0.2 ~ 2 part.
5. the compositions for improving water flood according to claim 4, is characterized in that: by its weight parts Golden jujube extracting solution 37.5 parts, Semen Ziziphi Spinosae extracting solution 28 parts, Caulis Polygoni Multiflori extracting solution 23 parts, γ-aminobutyric acid 1.8 parts.
6. the preparation method of the compositions for improving water flood according to claim 1, is characterized in that: concrete steps are as follows:
(1) Semen Ziziphi Spinosae fleece-flower root rattan extracting solution preparation: take broken Semen Ziziphi Spinosae and the Caulis Polygoni Multiflori of cutting, add the gross weight 6-15 times of purification hydration of Semen Ziziphi Spinosae fleece-flower root rattan to carry, micro-steaming and decocting 0.5-5h that boils, extracts 2-3 time, merge extractive liquid, concentrating under reduced pressure, through ethanol precipitate with ethanol, get supernatant, decompression is except ethanol, concentrated, be settled to 0.5-3 times of weight of medical material amount;
(2) Golden jujube extracting solution preparation: Golden jujube is through cleaning, removing the peel enucleation, fragmentation, adding Golden jujube gross weight 5-12 times purified water, 40-90 DEG C of lixiviate 1-10h, then be incubated at 20-50 DEG C, enzymolysis 1-6h is carried out by pectase and cellulase, the addition of described pectase and cellulase is the 0.01-0.1% (V/V) of solution total amount, filtration, sterilizing preparation;
(3) by the mixing of prescription amount, filtration, fill: by said extracted liquid mix homogeneously, filter and get final product.
7. the preparation method of the compositions for improving water flood according to claim 6, it is characterized in that: take γ-aminobutyric acid and be dissolved in its gross weight 5-20 times purified water, be stirred well to and dissolve completely, then mix homogeneously with step (1), (2) gained extracting solution by prescription amount according to above-mentioned steps (3), filter and get final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107050143A (en) * | 2017-04-14 | 2017-08-18 | 南京圣诺生物科技实业有限公司 | It is a kind of that there is the formula for improving sleep effect, composition and preparation method thereof |
| CN111686237A (en) * | 2020-06-01 | 2020-09-22 | 广州益联健生物科技有限公司 | A preparation containing myocardium peptide and golden silk jujube for preventing and treating cardiovascular diseases, and its preparation method |
| CN114027508A (en) * | 2021-12-03 | 2022-02-11 | 龙岩学院 | Functional food gamma-aminobutyric acid compound preparation for improving sleep |
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| CN104758397A (en) * | 2015-04-13 | 2015-07-08 | 广州赛莱拉干细胞科技股份有限公司 | Composition for improving sleep and preparation method thereof |
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