CN105412124A - Veterinary vitamin AD3E emulsion and preparation method thereof - Google Patents
Veterinary vitamin AD3E emulsion and preparation method thereof Download PDFInfo
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- CN105412124A CN105412124A CN201510871919.2A CN201510871919A CN105412124A CN 105412124 A CN105412124 A CN 105412124A CN 201510871919 A CN201510871919 A CN 201510871919A CN 105412124 A CN105412124 A CN 105412124A
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- Prior art keywords
- vitamin
- emulsion
- vitamins
- stirring
- acetate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a veterinary vitamin AD3E emulsion and belongs to the technical field of western medicine preparations. Compound vitamin preparations which are used most generally for preventing and treating animal vitamin deficiency diseases in the current breeding industry are compound vitamin pre-mixtures and multiplex vitamins of electrolytes. The compound vitamin preparations have the problems that the activity of vitamins can be easily affected in the process that the preparations are added into feed; most of the multiplex vitamins of electrolytes are solids and are prone to turbidity and precipitation after being dissolved; the absorbing rate of bodies for liposoluble vitamins is low and is only about 30%. The scheme is characterized in that the emulsion prepared through an O/W type is stable in property, vitamins will not precipitate in the stirring process and the process that a drug is taken with water, and the activity of the vitamins are not affected; the absorbing rate of bodies for the drug can reach up to 100%, and the biological utilization rate is about 98%; irritation on the oral mucosa is avoided. According to main application, the veterinary vitamin AD3E emulsion can be used for preventing and treating diseases caused by deficiency of vitamins of the kind.
Description
Technical field
The present invention relates to a kind of emulsion techniques for animals, be specifically related to a kind of vitamin AD for animals
3e Emulsion and preparation method thereof.
Background technology
Vitamin (vitamin) is humans and animals is the nutrient substance maintaining normal physiological function and must obtain from food, play an important role in growth of animal, metabolism and growth course, being maintain the necessary type organic matter of animal life activity, is also the important active substances keeping animal health.Vitamin content is in vivo little, but the nutrient substance that body is indispensable.Although the chemical constitution of various vitamin and character difference, they have following feature: the first, vitamin is prevalent in feedstuff; The second, the effect of vitamin mainly participates in the Metabolism regulation of body; Three, most vitamin, body can not synthesize or synthetic quantity deficiency, can not meet the needs of body, is constantly obtained by extraneous; Four, animal is very little to the demand of vitamin, but once shortage will cause corresponding avitaminosis, causes damage to animal health.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of vitamin AD for animals
3e Emulsion: treatment animal is owing to lacking the disease caused by fatsoluble vitamin; Supplement the nutrient substance of body, participate in the metabolism of energy; Improve the quality of meat, improve the fertility performance of animal; Improve the hair of animal, make it more glossy.
For achieving the above object, the invention provides following technical scheme:
The invention discloses a kind of vitamin AD for animals
3e Emulsion, consisting of of the every 100L medicine of this oral liquid:
Vitamin A palmitate 1,000,000,000 ~ 2,000,000,000 IU
Vitamin D
35000 ten thousand ~ 50,000 ten thousand IU
Vitamin E acetate 1 ~ 5kg
Emulsifying agent 10 ~ 80g
Antioxidant 5 ~ 200g
Antiseptic 30 ~ 600g
Surplus is purified water.
Further, described emulsifying agent is the mixing of one or more in Tween-40, tween 80, arabic gum, tragakanta, yolk or RH40.
Further, described antioxidant is the mixing of one or more in BHA, BHT or EDTA-2Na.
Further, described antiseptic is the mixing of one or more in thimerosal, benzoic acid, sodium benzoate, methyl hydroxybenzoate, ethyl hydroxybenzoate or butoben.
The present invention also discloses described vitamin AD for animals
3e Emulsion and preparation method thereof: the emulsifying agent getting recipe quantity is put in dosing cylinder, first dissolves the vitamin D of recipe quantity with a small amount of Vitamin E acetate
3be added in dosing cylinder with recipe quantity vitamin A palmitate, Vitamin E acetate after stirring and dissolving, after abundant stirring and dissolving is even, add the distilled water of temperature more than 60 DEG C while stirring to 80% of full dose, abundant stirring, evenly be filled with nitrogen from container bottom, add antioxidant while stirring, finally add the antiseptic of recipe quantity, after abundant stirring and dissolving, citric acid three sodium solution adjust ph to 6.0 with 50%, add purified water to full dose, stir, filter, subpackage after passed examination, fill nitrogen, sealing, lamp inspection, labeling, packaging, to obtain final product.
Detailed description of the invention
Further explanation is explained to invention has been by following test; the further restriction to invention cannot be interpreted as; those skilled in the art utilize the Professional knowledge of oneself all can make corresponding change and modify the present invention, and these also will fall into protection scope of the present invention.
Embodiment 1
The RH40 getting 30L puts in dosing cylinder, first dissolves the vitamin D of 10,000 ten thousand IU with a small amount of Vitamin E acetate
3, with 1,500,000,000 IU vitamin A palmitates after stirring and dissolving, 2kg Vitamin E acetate is added in dosing cylinder, after abundant stirring and dissolving is even, add the purified water of temperature more than 60 DEG C while stirring to 80% of full dose, abundant stirring, at the uniform velocity be filled with nitrogen from container bottom, add the BHA with a small amount of dissolve with ethanol recipe quantity while stirring, finally add the ethyl hydroxybenzoate of 100g, 25g butoben, after abundant stirring and dissolving, citric acid three sodium solution adjust ph to 6.0 with 50%, add to the full amount of water for injection, stir, filter, subpackage after passed examination, fill nitrogen, sealing, lamp inspection, labeling, packaging, obtain.
Clinical trial:
1. experimental animal:
There is the Cyan-Shank Partridge Chicken of the symptoms such as xerophthalmia, anorexia, weakness
2. trial drug
Vitamin AD
3e Emulsion, vitamin A oral liquid
3. test method
90 Cyan-Shank Partridge Chicken are divided into 3 groups at random, often organize 30.
A group adopts embodiment 1 vitamin AD
3e Emulsion is treated, by 0.1ml/kg body weight, and drinking water administration, continuous 10 days.
B group adopts vitamin A oral liquid to treat, by 5000IU/kg body weight, and drinking water administration, continuous 10 days.
C group is negative control group, does not give Drug therapy.
After treatment starts, the distribution of every day entry sick chicken health situation of change, treats and adds up therapeutic effect after 10 days, wherein invalid: after referring to 10 days, and sick chicken symptom, without obvious change, still keeps the effect before treating
Effective: after referring to 10 days, sick chicken symptom changes, and symptom is better than the effect before treating
Cure: after referring to 10 days, transference cure, sick chicken gets well.
4. outcome record and analysis
Result of the test is as shown in table 1
Table 1 different pharmaceutical treats the result of disease chicken
| Numbering | Group | Invalid number of elements | Effective number of elements | Cure number of elements |
| A | Test group | 3 | 28 | 26 |
| B | Drug control group | 10 | 20 | 16 |
| C | Matched group | 27 | 3 | 2 |
Remarks: matched group is spontaneous recovery
From above result, apply vitamin AD for animals
3e Emulsion is treated, and medication is after 10 days, and cure rate is 87%, and effective percentage is 90%; Application vitamin A oral liquid is treated, and medication is after 10 days, and cure rate is 53%, and effective percentage is 67%.The above results shows, the present invention obviously can cure the poultry of the A that is deficient in vitamin.
What finally illustrate is, above preferred embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although by above preferred embodiment to invention has been detailed description, but those skilled in the art are to be understood that, various change can be made to it in the form and details, and not depart from claims of the present invention limited range.
Claims (6)
1. a vitamin AD for animals
3e Emulsion, is characterized in that being prepared from by following composition: vitamin A palmitate, vitamin D
3, Vitamin E acetate, emulsifying agent, antioxidant, antiseptic and purified water.
2. vitamin AD for animals according to claim 1
3e Emulsion, is characterized in that: consisting of of every 100L medicine:
Vitamin A palmitate 1,000,000,000 ~ 2,000,000,000 IU
Vitamin D
35000 ten thousand ~ 50,000 ten thousand IU
Vitamin E acetate 1 ~ 5kg
Emulsifying agent 10 ~ 80g
Antioxidant 5 ~ 200g
Antiseptic 30 ~ 600g
Surplus is purified water.
3. vitamin AD for animals according to claim 1 and 2
3e Emulsion, is characterized in that: described emulsifying agent is the mixing of one or more in Tween-40, tween 80, arabic gum, tragakanta, yolk or RH40.
4. vitamin AD for animals according to claim 1 and 2
3e Emulsion, is characterized in that: described antioxidant is the mixing of one or more in BHA, BHT or EDTA-2Na.
5. vitamin AD for animals according to claim 1
3e Emulsion, is characterized in that: described antiseptic is the mixing of one or more in thimerosal, benzoic acid, sodium benzoate, methyl hydroxybenzoate, ethyl hydroxybenzoate or butoben.
6. the vitamin AD for animals described in claim 1 to 5 any one
3e Emulsion, its preparation method is as follows: the emulsifying agent getting recipe quantity is put in dosing cylinder, first dissolves the vitamin D of recipe quantity with a small amount of Vitamin E acetate
3be added in dosing cylinder with the vitamin A palmitate of recipe quantity, Vitamin E acetate after stirring and dissolving, after abundant stirring and dissolving is even, add the distilled water of temperature more than 60 DEG C while stirring to 80% of full dose, abundant stirring, evenly be filled with nitrogen from container bottom, add antioxidant while stirring, finally add the antiseptic of recipe quantity, after abundant stirring and dissolving, citric acid three sodium solution adjust ph to 6.0 with 50%, add purified water to full dose, stir, filter, subpackage after passed examination, fill nitrogen, sealing, lamp inspection, labeling, packaging, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510871919.2A CN105412124A (en) | 2015-12-03 | 2015-12-03 | Veterinary vitamin AD3E emulsion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510871919.2A CN105412124A (en) | 2015-12-03 | 2015-12-03 | Veterinary vitamin AD3E emulsion and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105412124A true CN105412124A (en) | 2016-03-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510871919.2A Pending CN105412124A (en) | 2015-12-03 | 2015-12-03 | Veterinary vitamin AD3E emulsion and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111228298A (en) * | 2020-01-15 | 2020-06-05 | 开封嘉骏生物科技有限公司 | Medicine for preventing and treating cattle and sheep flaccid paralysis and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004082398A1 (en) * | 2003-03-17 | 2004-09-30 | Dsm Ip Assets B.V. | Fat soluble vitamin feed supplements and processes for delivering same |
| CN102091080A (en) * | 2010-12-10 | 2011-06-15 | 上海恒丰强动物药业有限公司 | Nanoemulsion of liposoluble vitamin and preparation method thereof |
| CN103082091A (en) * | 2013-01-15 | 2013-05-08 | 广州格雷特生物科技有限公司 | Special nutrition strengthening solution for livestock and poultry and preparation method thereof |
| CN104997794A (en) * | 2015-07-31 | 2015-10-28 | 郑州赛科药业科技有限公司 | Long-acting composite vitamin oral emulsion for livestock and preparation method thereof |
-
2015
- 2015-12-03 CN CN201510871919.2A patent/CN105412124A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004082398A1 (en) * | 2003-03-17 | 2004-09-30 | Dsm Ip Assets B.V. | Fat soluble vitamin feed supplements and processes for delivering same |
| CN102091080A (en) * | 2010-12-10 | 2011-06-15 | 上海恒丰强动物药业有限公司 | Nanoemulsion of liposoluble vitamin and preparation method thereof |
| CN103082091A (en) * | 2013-01-15 | 2013-05-08 | 广州格雷特生物科技有限公司 | Special nutrition strengthening solution for livestock and poultry and preparation method thereof |
| CN104997794A (en) * | 2015-07-31 | 2015-10-28 | 郑州赛科药业科技有限公司 | Long-acting composite vitamin oral emulsion for livestock and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 朱仕铭: "多种维生素饲料添加剂的制备应用和展望", 《兽药饲料添加剂》 * |
| 罗明生等: "《药剂辅料大全》", 31 March 1993, 四川科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111228298A (en) * | 2020-01-15 | 2020-06-05 | 开封嘉骏生物科技有限公司 | Medicine for preventing and treating cattle and sheep flaccid paralysis and preparation method thereof |
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Application publication date: 20160323 |
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