CN102318832A - Nutrition agent for improving body anti-anoxia capability - Google Patents
Nutrition agent for improving body anti-anoxia capability Download PDFInfo
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- CN102318832A CN102318832A CN201110294776A CN201110294776A CN102318832A CN 102318832 A CN102318832 A CN 102318832A CN 201110294776 A CN201110294776 A CN 201110294776A CN 201110294776 A CN201110294776 A CN 201110294776A CN 102318832 A CN102318832 A CN 102318832A
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Abstract
The invention discloses a nutrition agent for improving body anti-anoxia capability. The nutrition agent is prepared from the following raw materials in parts by weight: 40-50 parts of tea polyphenol, 40-50 parts of arginine, 0.09-0.11 part of vitamin B1, 0.09-0.11 part of vitamin B2, 2.7-3.3 parts of vitamin C, 0.09-0.11 part of vitamin E and 6-8 parts of food acceptable auxiliary material. The experiment result shows that the nutrition agent for improving body anti-anoxia capability provided by the invention has effects of regulating body immunity function and stress adaptability, and improving the body anti-anoxia capability and plateau athletic capability.
Description
Technical field
The present invention relates to a kind of nutritional agents, particularly relate to a kind of nutritional agents that improves body's hypoxia tolerance.
Background technology
The product that is used for anti-anoxic in the market is many, is mainly two series products, and the first kind is prevention and curative medicine and health products to the heart Hypoxia and ischemia, and second type is prevention and curative medicine and the health products to high altitude anoxia.
In the market to the prevention of high altitude anoxia and the health products of supplemental treatment; Mainly be not enough to the body oxygen supply according to high altitude anoxia; Cause physical stress reaction and damage, use some tonifying Qi property cmm of simple prescription or compatibility and improve fuselage state, reach the effect of anti-plateau hypoxemia; These tonifying Qi property Chinese medicines mainly are genseng, the red sage root, American Ginseng etc., and these Chinese medicines are difficult for " getting angry " symptom that long-term use the, particularly young man are used the traditional Chinese medical science such as can producing dispute sore, scorching, nose is bleeding for a long time.Be exactly altitude environment growing plant medicine in addition; Like rhodiola root, ginkgo biloba p.e etc., the toxic and side effect of rhodiola root and ginkgo biloba p.e is littler than genseng, the red sage root, American Ginseng, but there are some researches show that rhodiola root influences growing of body; Rhodiola root and ginkgo leaf are medicines, should not eat for a long time.
Research shows that rhodiola root and extract thereof have anti-anoxic, antifatigue, radioresistance, antitumor, the anti-ageing function of waiting for a long time both at home and abroad at present; It has become the kind that Chinese Pharmacopoeia is included, and its main active is: rhodioside, catechin, gallic acid, progallin A etc.Tea Polyphenols is the polyphenol compound that from green tea, extracts; Mainly contain catechin, flavones and flavonols, leucoanthocyanidin and anthocyanidin, phenols and depside; Wherein catechin accounts for 60～80% of Tea Polyphenols extract, and wherein epigallocatechin and catechin and gallate are the main components of catechin.
Arginine has regulates body's immunity and effect that stress adaptive capacity, and the plateau hypoxemia can obviously reduce body's immunological function, makes body produce stress reaction.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art, a kind of nutritional agents that improves body's hypoxia tolerance is provided.
Technical scheme of the present invention is summarized as follows:
A kind of nutritional agents that improves body's hypoxia tolerance is processed by following raw material: Tea Polyphenols 40-50 part, arginine 40-50 part, vitaminB10 .09-0.11 part, vitamin B2 0.09-0.11 part, vitamin C 2.7-3.3 part, vitamin E 0.09-0.11 part, food acceptable auxiliary 6-8 part by weight.
Preferably said Tea Polyphenols is that 45 parts, said arginine are that 45 parts, said vitamin B1 are that 0.10 part, said vitamin B2 are that 0.10 part, said vitamin C are that 3 parts, said vitamin E are that 0.10 part, said food acceptable auxiliary are 7 parts.
Said food acceptable auxiliary is the additive that national regulation can be used for food, preferred starch or dextrin or compound sugar.
The formulation of said nutritional agents is capsule or tablet or adds in the food as food additives and to process functional food.
Advantage of the present invention is:
Experimental result shows that a kind of nutritional agents that improves body's hypoxia tolerance of the present invention has and regulates body's immunity and effect that stress adaptive capacity, improves the anti-anoxic function and the plateau locomitivity of body.
The specific embodiment
Embodiment below in conjunction with concrete is further described the present invention.
Embodiment 1-5
Each component of embodiment 1 is mixed into mixture will goes in No. 0 capsule, 436mg packs in each capsule.Or with the mixture compressing tablet, every 436mg.
Embodiment 2-embodiment 5 prepares the method for capsule and tablet with embodiment 1.
One, experimental technique:
Experiment 1
20 of male mice in kunming, body weight 20 ± 2g, available from Hygiene & Environmental Medical Science Inst., Academy of Military Medical Scien, credit number is: scxk-(army)-2009-003.Adapt to and fed 3 days; Change 15% casein synthetic diet (feed formula is with reference to AIN-96) and adapt to 5 days, be divided into control group and experimental group at random by body weight, 10 every group; Experimental group is on the basis of 15% casein feed; Every mouse is irritated the composition that stomach gives embodiments of the invention 1 every day, and control group continues to feed 15% casein feed, irritates the water that stomach gives equal volume every day; Weigh twice weekly, fed for two weeks after, carry out normal pressure airtight anoxia experiment, two groups of mouse are put into the 250ml wide-mouth bottle that fills the 15g soda lime respectively, 1 every bottle, seal with smearing the vaseline bottle cap, clock, be the termination index that clocks with breath stopped.Observe the time-to-live of mouse in airtight bottle.See experimental result 1 and result 2.
Experiment 2
16 of male mouse of kunming are fed, are handled by method adaptation nursing, random packet and the back of dividing into groups of experiment one, but every group of 8 mouse; After feeding for two weeks, bear a heavy burden at afterbody, control group and experimental mice are put into hypobaric chamber, the swimming exercise motion in the hypobaric chamber on simulation 5000m plateau, the time-to-live of record mouse by mouse body weight 2%.See experimental result 3 and table 3.
Experiment 3
30 of male mice in kunming, adopt from Hygiene & Environmental Medical Science Inst., Academy of Military Medical Scien's animal center (credit number is: scxk-(army)-2009-003), adapt to feed afterwards 3 days; Change 15% casein synthetic diet (feed formula is with reference to AIN-96) and adapt to 5 days; Be divided into normal group, control group and experimental group at random by body weight, 10 every group, normal group and control group continue to feed 15% casein feed; The composition of experimental group additional embodiment 1 on the basis of 15% casein feed; Replenish dosage and compensation process with testing one, fed for two weeks after, control group and experimental mice are put into hypobaric chamber; Swimming exercise motion in the hypobaric chamber on simulation 5000m plateau is after one hour; Kill three groups of mouse, get blood and tissues such as liver, skeletal muscle, detect the level and the anti-oxidant indexs such as blood lactic acid, blood urea nitrogen, liver and skeletal muscle glycogen of reflection organism fatigue situation.See experimental result 4 and result 5.
Two, experimental result
1 replenishes a kind of influence that improves the nutritional agents of body's hypoxia tolerance to the experiment mice body weight of the present invention
Table 1 demonstrates the mouse changes of weight situation of experimental session, and visible from table 1, mouse is replenished the nutritional agents of anti-the anoxic does not have tangible influence to weight of mice.
Changes of weight situation during table 1 mouse experiment (X ± SD, gram)
2 replenish a kind of influence that improves the body's hypoxia tolerance nutritional agents to mouse normal pressure airtight anoxia Survival Time of the present invention
The Survival Time of mouse normal pressure airtight anoxia is the overall target of reflection animal economy anti-anoxia ability.Visible from the result of table 2, replenish the Survival Time (P＜0.05) that the nutritional agents of anti-the anoxic can obviously improve the normal pressure airtight anoxia experiment of mouse.Show that replenishing the nutritional agents of anti-the anoxic can significantly improve body's hypoxia tolerance.
Table 2 replenishes the influence of nutritional agents of the present invention to mouse normal pressure airtight anoxia Survival Time
Compare with control group: * P＜0.05
3 replenish a kind of influence that improves the body's hypoxia tolerance nutritional agents to mouse hypoxia exercise survival rate of the present invention
Swimming Survival Time under the mouse normal pressure airtight anoxia situation is the overall target of reflection body labour capacity under the anaerobic environment situation.We can be all dead 2～3 hours heavy burden mouse according to the experiment experience in the plains region, the death time of record mouse; Can reflect the effect of nutritional agents to the mouse movement ability; But because the volumetric expansion of swimming mouse under low-pressure state, buoyancy increases, and mouse need not firmly can be kept afloat; Also has the mouse survival during therefore by 5 hours; And do not have dead sign of short time, we promptly stop experiment in swimming in the time of 5 hours, judge the influence of extra-nutrition agent to hypoxemia mouse movement ability according to 5 hours mouse survival rate of experiment.Visible from the result of table 3, replenish the nutritional agents of anti-the anoxic and can obviously improve the survival rate that mouse is swum in 5 hours hypobaric chamber, the Survival Time of two groups of mouse is indifference then; Show that replenishing the nutritional agents of anti-the anoxic can significantly improve the locomitivity under the body hypoxia-bearing environment.
5 hours current deposit rates of table 3 hypoxemia swimming with a load attached to the body campaign mouse and Survival Time
4 replenish a kind of influence that improves the body's hypoxia tolerance nutritional agents to hypoxia exercise mouse fatigue conditions of the present invention
The index of the evaluation organism fatigue situation of generally acknowledging at present is the overall evaluation indexs such as glycogen levels of blood lactate level, blood uric acid nitrogen level and muscle; This research has also been observed these indexs and has been estimated sports fatigue situation and the antifatigue effect of nutritional agents of body under low-oxygen environment, and the body result sees table 4 and table 5.Visible from these results, after control group mice was swum one hour under hypoxemia, with compared with normal, blood lactic acid, urea nitrogen levels obviously raise, and skeletal muscle and liver glycogen then obviously reduce; These indexs of extra-nutrition agent mouse then obviously are better than control group mice, more near the normal group level; Show that the extra-nutrition agent can obviously improve the fatigue conditions of hypoxia exercise mouse, have to help improve the labour capacity of body on the plateau.
Table 4 replenishes the nutritional agents of anti-the anoxic to the blood lactic acid of reflection hypoxia exercise mouse fatigue conditions and the influence of UAN level
Compare with normal group: * P＜0.05, * * P＜0.01; Compare with control group: #P＜0.05, ##P＜0.01
Table 5 replenishes the nutritional agents of anti-the anoxic to the liver glycogen of reflection hypoxia exercise mouse fatigue conditions and the influence of skeletal muscle glycogen
Compare with normal group: * P＜0.05, * * p＜0.01; Compare with control group: #P＜0.05, ##P＜0.01
5 replenish a kind of influence that improves the body's hypoxia tolerance nutritional agents to hypoxia exercise mice serum and liver antioxidation status of the present invention
Mouse movement will consume a large amount of oxygen, and oxygen supply is not enough under the hypoxemia situation of plateau, can cause that the dysoxidation of body and the anti-oxidation function of body change, and produces the oxidative stress damage.For this reason, we have detected anti-oxidant index MDA (MDA) and hepatocuprein (SOD) after the mouse hypoxia exercise, measure the result and show; With compared with normal; The serum MDA level obviously raises after the mouse hypoxia exercise, the SOD activity then obviously reduces, and the extra-nutrition agent can obviously reduce the amplitude of this variation, more approaches the normal group level; And compare with control group and to have statistical significance, see table 6 for details.The testing result of the anti-oxidant index of liver shows that Changing Pattern and the serum of SOD are basic identical, and the variation of MDA is then not obvious, does not see statistical significance, sees table 7 for details.
Table 6 replenishes the nutritional agents of anti-the anoxic to the blood MDA of mouse antioxidation status and the influence of SOD level
Compare with normal group: * P＜0.05, * * p＜0.01; Compare with control group: #P＜0.05.
Table 7 replenishes the influence of the nutritional agents of anti-anoxic the to the liver MDA and the SOD level of mouse antioxidation status
Compare with normal group: * P＜0.05, * * p＜0.01; Compare with control group: #P＜0.05, ##P＜0.01.
Three, conclusion
Zoopery is the result show; Supplementary copy invention every day nutritional agents is after 14 days; Supplementary copy invention nutritional agents does not have tangible influence to weight of mice; Swimming exercise 5 hour the current deposit rate of mouse in the hypobaric chamber on simulation 5000m plateau is apparently higher than control group, and the levels such as blood lactic acid, blood urea nitrogen, liver and skeletal muscle glycogen that reflect the organism fatigue situation after a hour of moving obviously are better than control group, and the anti-oxidant index of the blood of body and liver also obviously is better than control group.
A kind of nutritional agents that improves body's hypoxia tolerance that experiment showed, embodiment 2-5 also has and the similar result of the nutritional agents of embodiment 1.
Nutritional agents of the present invention is the extract and the synthetic nutrient composite article of natural plants, can be made for capsule, tablet or makes an addition in the food.Experiment proof nutritional agents of the present invention can be before the plateau worker gets into the plateau low oxygen area, continuously every day part vic, also can under the situation of plateau hypoxemia, take in preceding 2 hours in strenuous exercise, every day, dose was about 3～4g.Nutritional agents of the present invention be applicable to the plateau worker before getting into the high altitude anoxia zone with a period of time that gets in prolonged application, can improve the hypoxia-bearing capability and the labour capacity of body; Also can be used for travelling, explore, carry out and speedily carry out rescue work and the emergent in a short time of other operating personnels taken, to increase the hypoxia-bearing capability and the labour capacity of body, the sign sense that alleviates acute high altitude reaction to the highlands.
Claims (4)
1. a nutritional agents that improves body's hypoxia tolerance is characterized in that being processed by following raw material by weight: Tea Polyphenols 40-50 part, arginine 40-50 part, vitaminB10 .09-0.11 part, vitamin B2 0.09-0.11 part, vitamin C 2.7-3.3 part, vitamin E 0.09-0.11 part, food acceptable auxiliary 6-8 part.
2. a kind of nutritional agents that improves body's hypoxia tolerance according to claim 1 is characterized in that said Tea Polyphenols is that 45 parts, said arginine are that 45 parts, said vitamin B1 are that 0.10 part, said vitamin B2 are that 0.10 part, said vitamin C are that 3 parts, said vitamin E are that 0.10 part, said food acceptable auxiliary are 7 parts.
3. a kind of nutritional agents that improves body's hypoxia tolerance according to claim 1 and 2 is characterized in that said food acceptable auxiliary is starch or dextrin or compound sugar.
4. a kind of nutritional agents that improves body's hypoxia tolerance according to claim 1, the formulation that it is characterized in that said nutritional agents are capsule or tablet or add in the food as food additives and to process functional food.
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| CN201110294776A CN102318832A (en) | 2011-09-30 | 2011-09-30 | Nutrition agent for improving body anti-anoxia capability |
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| CN201110294776A CN102318832A (en) | 2011-09-30 | 2011-09-30 | Nutrition agent for improving body anti-anoxia capability |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104856014A (en) * | 2015-04-24 | 2015-08-26 | 浙江海力生生物科技有限公司 | Emergency food and preparation method thereof |
| CN112042796A (en) * | 2020-08-03 | 2020-12-08 | 北京体育大学 | Anti-hypoxia energy bar and preparation method and application thereof |
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| CN1739584A (en) * | 2005-09-23 | 2006-03-01 | 北京东方兴企食品工业技术有限公司 | Phosphatide granule with subsidiary function of reducing blood fat |
| CN1943573A (en) * | 2005-03-15 | 2007-04-11 | 中国人民解放军第三军医大学 | Use of vitamin C and arginine composition in anti-anoxic medicine and health product |
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- 2011-09-30 CN CN201110294776A patent/CN102318832A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1943573A (en) * | 2005-03-15 | 2007-04-11 | 中国人民解放军第三军医大学 | Use of vitamin C and arginine composition in anti-anoxic medicine and health product |
| CN1739584A (en) * | 2005-09-23 | 2006-03-01 | 北京东方兴企食品工业技术有限公司 | Phosphatide granule with subsidiary function of reducing blood fat |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104856014A (en) * | 2015-04-24 | 2015-08-26 | 浙江海力生生物科技有限公司 | Emergency food and preparation method thereof |
| CN112042796A (en) * | 2020-08-03 | 2020-12-08 | 北京体育大学 | Anti-hypoxia energy bar and preparation method and application thereof |
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Application publication date: 20120118 |