CN105410365A - Feed additive capable of replacing antibiotics and application of feed additive - Google Patents
Feed additive capable of replacing antibiotics and application of feed additive Download PDFInfo
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Abstract
The invention discloses a feed additive capable of replacing antibiotics and application of the feed additive. The feed additive is prepared from the following raw materials in weight percent: 10 % to 20% of glyceryl monolaurate, 20% to 40% of didansylhistamine, 30% to 60% of glycerin monostearate and 0 to 40% of a carrier. The feed additive provided by the invention is prepared by taking the glyceryl monolaurate, the didansylhistamine and the glycerin monostearate as the main raw materials and compounding according to a proper ratio and can replace the antibiotics in a piglet cultivation process; the disease-resisting capability of piglets is improved, the development of intestinal tracts is promoted and the functions of the intestinal tracts are improved; the daily gain and feed intake are remarkably improved, the diarrhea rate and the death and culling rate are remarkably reduced, the feed conversion ratio is improved, the growth and development are promoted, the economic benefits of cultivation are improved, the utilization of the antibiotics is reduced, the environment pollution is reduced, and the green, safe and healthy development of a pig industry is facilitated.
Description
Technical field
The present invention relates to field of feed additive technology, particularly relate to a kind of alternative antibiotic feed addictive and application thereof.
Background technology
Under high density large-scale cultivation mode; deliver for sale as early as possible for making cultivating live pig; reduce sick and dead; often exceed standard in piglet breeding process and use containing heavy metal, hormone, antibiotics additive and various medicine; this kind of material remains and with cultivation excreta entered environment, all drastically influence the health of the mankind in piglet body.
Along with people are to the concern of food security and human health, change there occurs to the requirement of meat products, urgently wish the launch of green, safety, nutrition.Therefore, be necessary to adopt safe, efficient, green functional food ingredients exploitation feed addictive to carry out the application of substitute antibiotics in piglet cultivation, can not only heavy metal free, hormone, antibiotic residual, and improve resistance against diseases, promote intestinal growth and function of intestinal canal perfect, improve daily gain and feed intake, reduce death rate, improve food conversion ratio, enhancing development, increase economic efficiency, reduce environmental pollution.
Glyceryl monolaurate, has broad-spectrum antibacterial activity and specific anti-virus ability; Dilaurate glyceride, itself does not have an inhibitory anti-virus ability, but can discharge laurate through intestinal flora metabolism and digestive ferment effect in enteron aisle, has potential inhibitory anti-virus ability; Glycerin monostearate, there is excellent emulsification function, all safe, nontoxic, the polyfunctional food additives of generally acknowledging in the world, be widely used in varieties of food items, cosmetics and medical product, being GRAS (It is generally accepted safety) the based food additive that U.S. FDA is assert, is also ministry of Health of China approved for the security classes additive of varieties of food items and feed.
At present, said components is anticorrosion mainly for the preparation of tool, the feed addictive of antimildew function, such as:
Authorization Notice No. is that the patent of invention document of CN1235520C discloses glyceryl monolaurate microemulsion and its preparation method and application, and the component of this glyceryl monolaurate microemulsion and content are: surface-active 15 ~ 40%; Cosurfactant 10 ~ 30%; Glyceryl monolaurate 1 ~ 20%; Water or sodium chloride or organic monoacid salt 15 ~ 40%.This product can be widely used in foods and cosmetics, plays anticorrosion, mildew-resistant, extends the effect of shelf life of products.
Application publication number is that the application for a patent for invention document of CN101797011A discloses a kind of Midew preventive for feed, and this Midew preventive for feed contains glyceryl monolaurate, sodium dehydroacetate, calcium propionate and carrier.This Midew preventive for feed addition is little, does not affect animal palatability, and when being applied to feedstuff mildew, moisture-proof good heat resistance, affects little by acid-base value, has the effect of the microorganism such as bacterium and fungi efficiently suppressing and kill in feed.
In addition, also studies have reported that by said components for the preparation of alternative antibiotic feed addictive, such as:
Application publication number is that the application for a patent for invention document of CN104839516A discloses a kind of composite poultry feed, this feed is made up of each component of following weight portion: corn 20 ~ 50 parts, dregs of beans 15 ~ 21 parts, 10 ~ 35 parts, wheat bran, rapeseed dregs 5 ~ 20 parts, 3 ~ 10 parts, secondary powder, 4 ~ 6 parts, vinasse powder, 3 ~ 6 parts, rice bran, 2 ~ 8 parts, feed grade jujube powder, fish meal 4 ~ 8 parts, spirulina powder 1 ~ 5 part, Chinese medicine additive 3 ~ 5 parts, oyster shell whiting 0.5 ~ 5 part, calcium powder 1 ~ 3.5 part, 0.2 ~ 1 part, brown sugar, bone meal 0.55 ~ 0.75 part, salt 0.3 ~ 0.4 part, feed addictive 0.1 ~ 0.4 part, trace mineral supplement 0.1 ~ 0.3 part, B B-complex 0.3 ~ 0.5 part, glyceryl monolaurate 0.2 ~ 0.6 part.This feed can promote in poultry body and the generation of organic trace element and enrichment in egg, reduces antibiotics and the use amount of additive and the drug residue of poultry prod.
Application publication number is that the application for a patent for invention document of CN103005210A discloses a kind of alternative antibiotic pig feed additive and its preparation method and application, component in the formula of this pig feed additive and parts by weight thereof are: Divine Comedy 1 ~ 5 part, Radix Angelicae Sinensis 1 ~ 5 part, the Radix Astragali 1 ~ 5 part, hawthorn 1 ~ 5 part, Radix Codonopsis 1 ~ 5 part, citric acid 10 ~ 20 parts, lactic acid 10 ~ 20 parts, bag is by phosphoric acid 20 ~ 30 parts, probiotics 5 ~ 10 parts, yeast cell wall polysaccharide 5 ~ 10 parts, composite plant essential oil 1 ~ 5 part and 5 ~ 10 parts, carrier.Wherein, wrapping by phosphoric acid is the mixture of list/bi-tristearin and phosphoric acid.This feed addictive can substitute antibiotics completely, solves the problems such as antibiotic resistance, medicine are residual, Use out of range.
Application publication number is that the application for a patent for invention document of CN102696883A discloses a kind of feed addictive and application thereof, and this feed addictive by weight percentage, comprising: 20 ~ 60% glyceryl monolaurates, 10 ~ 40% calcium propionates, 0 ~ 50% feed vector.This feed addictive can not only the growth and breeding of effective mould fungus inhibition, extend feed in the storage period in damp and hot season, and the effect that there is inhibitory anti-virus, reduce antibiotic use in feed, promote growth of animal, improve animal dis motility rate and resistance against diseases.
But find through mechanistic research, the additive as antibiotic substitute needs to consider the problems such as palatability, intestinal environment balance, gut flora balance, if improper use may produce hydraulic performance decline, intestinal environment imbalance and flora imbalance on the contrary; Can be used in disclosed in above-mentioned document replacing antibiotic feed addictive, although can substitute antibiotics to a certain extent, but there is the overweight or problem such as to kick the beam of this feed addictive bactericidal effect in livestock and poultry body in it, have impact on the growth of livestock and poultry, cause antibiotic substitution effect not good, still have much room for improvement, and do not consider the impact that laurate list/double glyceride proportioning balances intestinal environment balance and gut flora.
Summary of the invention
The invention provides a kind of alternative antibiotic feed addictive and application thereof, in piglet cultivation, add this feed addictive can the use of substitute antibiotics, improve piglet disease-resistant ability, promote animal intestinal to grow and function of intestinal canal perfect, raising daily gain and feed intake, reduce diarrhea rate and death rate, improve food conversion ratio, promote animal growth, improve fanning economics, reduce antibiotic usage, reduce environmental pollution.
Technical scheme of the present invention is as follows:
A kind of feed addictive, by weight percentage, comprising:
The present invention is directed to the impact on palatability, intestinal environment balance, gut flora balance of laurate list/double glyceride content and proportioning, and contribute to the emulsification of enteral nutrition substance digestion absorption, optimize to obtain and there is good phagostimulating effect, little to GI irritation, and there is the animal feed antibiotic substituting agent formula suppressing harmful bacteria the infringement of enteron aisle not to be caused again to the effect of gut flora extra-inhibitory.
Above-mentioned feed addictive is after piglet searches for food and enters animal intestinal, on the one hand, utilize glyceryl monolaurate and the lauric antibiosis and antiviral functions deriving from dilaurate glyceride, exogenous protective barrier is together constructed in enteron aisle, kill the exogenous pathogen bacterium invading enteron aisle, improve the general level of the health of cultivated animals, improve providing safeguard for infant animal immune system; On the other hand, stimulate gut flora to produce acetic acid, propionic acid, butyric acid, growing for intestinal cell provides energy, promotes intestinal health.
Adopt glyceryl monolaurate and the dilaurate glyceride of specific proportioning, the mouthfeel of feed addictive can be made good, for piglet, there is good food calling effect, improve feed intake and daily gain.
Adopt the glycerin monostearate of suitable dose can emulsification feedstuff composition, promote digesting and assimilating in enteron aisle, promote the formation of chyme particulate.And find through experiment, glycerin monostearate can promote the performance of the antibiosis and antiviral functions of glyceryl monolaurate and dilaurate glyceride further, and for piglet, improve feed intake and daily gain, strengthen resistance against diseases.
More preferably, described feed addictive, by weight percentage, comprising:
Further preferably, described feed addictive, by weight percentage, comprising:
More preferably, described feed addictive, by weight percentage, comprising:
As preferably, described carrier is silica, maltodextrin or starch.Above-mentioned carrier is conducive to list/dilaurate glyceride and the dispersion of glycerin monostearate in feed, and not with its reaction, be conducive to the performance of antibiotic substitution effect.
Present invention also offers a kind of animal feed, containing above-mentioned feed addictive in this animal feed.This animal feed can directly apply to animal-breeding, can the use of half amount or replacing whole feeding antibiotic, improves immunity and the survival rate of animal, promotes growth of animal.
Described antibiotic comprises: colistin sulfate and Florfenicol.
Described animal feed is feed stripped.Particularly, described feed stripped is pig feed.
As preferably, by weight percentage, the addition of described feed addictive in animal feed is 0.05 ~ 0.3%.
In feed addictive of the present invention, the consumption of glyceryl monolaurate, dilaurate glyceride, glycerin monostearate must be suitable for; otherwise too high levels feed addictive can become puckery excessively strong with antibiosis and antiviral functions because of mouthfeel; feed intake is caused to decline and intestinal microflora imbalance; daily gain is caused to reduce; and the too low feed addictive of content can be inadequate because of dosage; one protective barrier can not be constructed in enteron aisle, act on very micro-, to feed intake and daily gain raising effect less.
As preferably, described animal feed comprises feedstuff and described feed addictive; By weight percentage, the formula of described feedstuff is: corn 30.0 ~ 65.0%, wheat 9.0 ~ 14.0%, secondary powder 4.0 ~ 6.0%, dehulled soybean meal 16 ~ 20%, expanded soybean 6.0 ~ 8.0%, high lactose whey powder 10.0 ~ 14%, imported fish meal 3.0 ~ 6.0%, skimmed milk power 1.0 ~ 3.0%, premix 1.0 ~ 5.0%, stone flour 1.0 ~ 3.0%;
By weight percentage, the nutritional labeling of described feedstuff is: crude protein 16 ~ 23%, lysine 0.8 ~ 1.6%, methionine 0.5 ~ 0.8%, cystine 0.3 ~ 0.6%, threonine 0.8 ~ 1.2%, tryptophan 0.2 ~ 0.4%, total calcium 1.0 ~ 2.0%, total phosphorus 0.8 ~ 1.0%, available phosphorus 0.4 ~ 0.6%.
More preferably, when described animal feed is pig starter feed, the formula of described feedstuff is: by weight percentage, corn 36.0%, wheat 12.0%, secondary powder 5.0%, dehulled soybean meal 17.5%, expanded soybean 8.0%, high lactose whey powder 12.5%, imported fish meal 5.0%, skimmed milk power 2.0%, pig premix 1.0%, stone flour 1.0%;
By weight percentage, the nutritional labeling of described feedstuff is: crude protein 22%, lysine 1.4%, methionine 0.6%, cystine 0.4%, threonine 0.9%, tryptophan 0.3%, total calcium 1.0%, total phosphorus 0.85%, available phosphorus 0.5%.
Present invention also offers a kind of preparation method of animal feed, comprising: described feed addictive is added in feedstuff, by be uniformly mixed or extruder grain mode obtains animal feed.Described extruder grain can adopt comminutor to carry out.
Present invention also offers described feed addictive as the application of Substitutes For Antibiotic in pig starter feed.
Compared with prior art, the present invention has following beneficial effect:
(1) the present invention is with glyceryl monolaurate, dilaurate glyceride, glycerin monostearate is primary raw material, can partly measure or the use of full dose substitute antibiotics in piglet cultivation according to Optimum Contents and the composite obtained feed addictive of ratio, there is the effect suppressing harmful bacteria the infringement of enteron aisle not to be caused again to gut flora extra-inhibitory, dilaurate glyceride slow releasing laurate under gut flora and digestive ferment effect simultaneously, little to GI irritation, and play energy supply continuously and healthily and inhibitory anti-virus effect, increase phagostimulating effect, promote animal growth, improve fanning economics, reduce antibiotic usage, thus minimizing environmental pollution.
(2) feed addictive of the present invention can not use the resistance against diseases improving piglet under antibiotic prerequisite, reduce sick probability, improve survival rate, reduce the diseases such as diarrhoea, stimulate gut flora fermentation produce acetic acid, propionic acid, butyric acid, promote intestinal growth and function of intestinal canal perfect.
(3) feed addictive of the present invention can also promote the emulsification of other compositions of feedstuff, promotes the formation of chyme particulate, strengthens the catabolism of gut flora to forage protein and carbohydrate, promotes that nutrient digestion absorbs, accelerate the growth of piglet.
(4) feed addictive of the present invention is natural, green, safe feed addictive, and animal can not be made to develop immunity to drugs, and no drug residue is pollution-free; ensure that meat products quality safety is harmless; local flavor is better, for pig-breeding brings more green, safe protection, has using value.
Detailed description of the invention
Be clearly and completely described the technical scheme in the present invention below in conjunction with specific embodiment, every simple distortion that other are made when not departing from core of the present invention or amendment all fall into protection scope of the present invention.
In the following example, the preparation method of feed is as follows:
(1) each raw material is evenly pulverized, then proportionally mix, obtain feed addictive;
(2) feed addictive is added in feedstuff by certain addition; fully mix with horizontal steel wing double worm mixer; then bucket elevator is delivered to by belt type conveyer; through bucket elevator, material is delivered in comminutor again; under the effect of the inner pressure roller of comminutor and template; express material is become particle, obtained feed.
Wherein, the formula of feedstuff is: by weight percentage, corn 36.0%, wheat 12.0%, secondary powder 5.0%, dehulled soybean meal 17.5%, expanded soybean 8.0%, high lactose whey powder 12.5%, imported fish meal 5.0%, skimmed milk power 2.0%, pig premix 1.0%, stone flour 1.0%;
The nutritional labeling of described feedstuff is: by weight percentage, crude protein 22%, lysine 1.4%, methionine 0.6%, cystine 0.4%, threonine 0.9%, tryptophan 0.3%, total calcium 1.0%, total phosphorus 0.85%, available phosphorus 0.5%.
The feedstuff formula mentioned in the following example is identical.
Above-mentioned feed addictive refers to generation of the present invention antibiotic feed additive, antibiotic or for antibiotic feed additive and antibiotic mixture.
Embodiment 1
, hereditary basis principle of similarity close according to body weight, chooses 23 age in days weanling pigs (male and female half and half) 240, is divided into 4 groups at random: test group and control group 1 ~ 3, often organizes 3 repetitions, and often repeating 20 is a hurdle; To feed weanling pig with pig starter feed, experimental period is 28 days.
In above-mentioned test group and control group 1 ~ 3 composition of pig starter feed and formula as follows:
(1) test group (full dose substitute antibiotics): for antibiotic feed additive+feedstuff
Formula for antibiotic feed additive is: by weight percentage, glyceryl monolaurate 15%, dilaurate glyceride 30%, glycerin monostearate 30% and carrier (silica) 25%.Be 0.1% for the addition of antibiotic feed additive in pig starter feed.
(2) control group 1 (blank): do not add for antibiotic feed additive, only use feedstuff.
(3) control group 2 (partly measuring substitute antibiotics): for antibiotic feed additive+antibiotic+feedstuff
Formula for antibiotic feed additive is: by weight percentage, glyceryl monolaurate 15%, dilaurate glyceride 30%, glycerin monostearate 30% and carrier (silica) 25%.
Antibiotic is: colistin sulfate.
Be 0.1% for the addition of antibiotic feed additive in pig starter feed; The addition of antibiotic in pig starter feed is 50mg/kg.
(4) control group 3 (antibiotic group): antibiotic+feedstuff
Antibiotic: colistin sulfate.
The addition of antibiotic in pig starter feed is 100mg/kg.
During off-test, collect fresh excrement sample and measure faecal microbiota diversity and short-chain fat acid content.Result is as follows:
Data record and recruitment evaluation index (see table 1 and table 2)
Table 1. weanling pig feeding effect
Note: data are all means ± SD; Same column different lowercase representative there is significant difference, P ﹤ 0.05.
The impact of table 2 weanling pig faecal microbiota diversity and SCFA
Note: observation species number and Shannon index are all the indexs characterizing bacterial diversity; Data are all means ± SD; Same column different lowercase representative there is significant difference, P ﹤ 0.05.
From table 1 ~ 2: test group and control group 2 daily gain and feed intake are all significantly higher than control group 1 and control group 3, especially control group 2 daily gain and feed intake increase by 19.7% and 12.8% than control group 3 respectively, and feedstuff-meat ratio, diarrhea rate, death rate also obviously decline.
The piglet of test group increases by 5% than the daily gain of control group 3, and death rate is zero, illustrate and adopt the feed addictive of test group 1 to have result of use more better than colistin sulfate, and greatly reduce the antibiotic use of colistin sulfate, obtained feed highly effective and safe more.
Simultaneously, the gut flora number of test group and control group 2 and Shannon index all higher than control group 1 lower than control group 3, show to adopt the feed addictive of test group to have good inhibition to gut flora, but do not cause intestinal bacilli illness, comprehensive explanation, the feed addictive highly effective and safe more of test group, can effectively improve piglet disease-resistant ability, promotes piglet growth.
Embodiment 2
Experiment adopts single-factor design, the principle that, hereditary basis close according to body weight is similar, chooses 28 age in days weanling pigs (male and female half and half) 240, is divided into 4 groups at random: control group, processed group A, processed group B, processed group C, often organize 3 repetitions, each repetition 20 weanling pigs; To feed weanling pig with pig starter feed, experimental period is 60 days.
The formula of the pig starter feed in above-mentioned control group and processed group A ~ C is specific as follows:
(1) control group:
Feed mode: only at the 1st week and the 5th week feed antibiotic and the feedstuff of experimental period, all the other times only adopt feedstuff to feed piglet as pig starter feed.
Antibiotic (Florfenicol): the addition in pig starter feed is 100mg/kg.
(2) processed group A:
Feed mode: only at the 1st week of experimental period and the 5th week antibiotic of feeding, mixture for antibiotic feed additive and feedstuff, all the other times only adopt to feed piglet as pig starter feed for antibiotic feed additive and feedstuff.
Wherein, antibiotic (Florfenicol): the addition of the 1st week is 100mg/kg, the addition of the 5th week is 50mg/kg.
Formula for antibiotic feed additive is: by weight percentage, glyceryl monolaurate 20%, dilaurate glyceride 40%, glycerin monostearate 30% and carrier (maltodextrin) 10%.Be 0.1% for the addition of antibiotic feed additive in pig starter feed.
(3) processed group B:
Feed mode: only at the 1st week of experimental period and the 5th week antibiotic of feeding, mixture for antibiotic feed additive and feedstuff, all the other times only adopt to feed piglet as pig starter feed for antibiotic feed additive and feedstuff.
Wherein, antibiotic (Florfenicol): the addition of the 1st week is 50mg/kg, the addition of the 5th week is 50mg/kg.
Formula for antibiotic feed additive is: by weight percentage, glyceryl monolaurate 20%, dilaurate glyceride 40%, glycerin monostearate 30% and carrier (maltodextrin) 10%.Be 0.1% for the addition of antibiotic feed additive in pig starter feed.
(4) processed group C:
Feed mode: whole process only adopts to feed piglet as pig starter feed for antibiotic feed additive and feedstuff.
Be 0.1% for the addition of antibiotic feed additive in pig starter feed.Formula for antibiotic feed additive is: by weight percentage, glyceryl monolaurate 20%, dilaurate glyceride 40%, glycerin monostearate 30% and carrier (maltodextrin) 10%.
Data record and recruitment evaluation index (see table 3)
Table 3. weanling pig feeding effect
Note: data are all Mean ± SD, the lowercase of going together different representative has significant difference, P ﹤ 0.05.
As shown in Table 3: the daily gain of processed group A, B, C piglet and feed intake increase by 12.3% ~ 14.9% and 6.7% ~ 10.8% than control group (i.e. full dose antibiotic group) respectively, feedstuff-meat ratio and the death rate also obviously decline simultaneously, illustrate to adopt, for antibiotic feed additive, there is result of use more better than Florfenicol, and greatly reduce the antibiotic use of Florfenicol, obtained feed highly effective and safe more, can effectively improve piglet disease-resistant ability, promote piglet growth.
Embodiment 3
Experiment adopts single-factor design, the principle that, hereditary basis close according to body weight is similar, choose 28 age in days weanling pigs (male and female half and half) 300, be divided into 5 groups at random: processed group, control group I, control Group II, control Group II I, control group IV, often organize 3 repetitions, often repeat 20, to feed weanling pig with pig starter feed, experimental period is 30 days.
The formula of the pig starter feed in above-mentioned processed group and control group I ~ IV is specific as follows:
(1) processed group: for antibiotic feed additive+feedstuff
Formula for antibiotic feed additive is: by weight percentage, glyceryl monolaurate 20%, dilaurate glyceride 30%, glycerin monostearate 30% and carrier (silica) 20%.
Be 0.1% for the addition of antibiotic feed additive in pig starter feed.
(2) control group I: for antibiotic feed additive+feedstuff
Only using glyceryl monolaurate as antibiotic feed additive, its addition in pig starter feed is identical with the addition of the glyceryl monolaurate of processed group, and namely 0.02%.
(3) control Group II: for antibiotic feed additive+feedstuff
Only using the mixture of glyceryl monolaurate, glycerin monostearate and carrier (silica) as antibiotic feed additive, the addition of its each component in pig starter feed is identical with the addition of component each in processed group, that is: glyceryl monolaurate 0.02%, glycerin monostearate 0.03%, carrier (silica) 0.02%.
(4) control Group II I: for antibiotic feed additive+feedstuff
Only using the mixture of glyceryl monolaurate, dilaurate glyceride and carrier (silica) as antibiotic feed additive, the addition of its each component in pig starter feed is identical with the addition of component each in processed group, that is: glyceryl monolaurate 0.02%, dilaurate glyceride 0.03%, carrier (silica) 0.02%.
(5) control group IV: for antibiotic feed additive+feedstuff
Only using the mixture of glyceryl monolaurate, dilaurate glyceride and glycerin monostearate as antibiotic feed additive, the addition of its each component in pig starter feed is identical with the addition of component each in processed group, that is: glyceryl monolaurate 0.02%, dilaurate glyceride 0.03%, glycerin monostearate 0.03%.
Data record and recruitment evaluation index (see table 4)
Table 4. weanling pig feeding effect
Note: data are all Mean ± SD, the lowercase of going together different representative has significant difference, P ﹤ 0.05.
As shown in Table 4, the daily gain of processed group and feed intake are respectively than control group I, control Group II, control Group II I and control group IV increases by 9.3% and 6.8%, 7.2% and 6.4%, 2.8% and 2.0%, 1.2% and 0.4%, feedstuff-meat ratio is compared with control Group II with control group I, death rate also obviously declines, illustrate that dilaurate glyceride and glycerin monostearate all can effectively improve piglet disease-resistant ability, promote piglet growth, and the effect of dilaurate glyceride is greater than glycerin monostearate, comprehensive instruction book glyceryl laurate ester and dilaurate glyceride, glycerin monostearate and carrier (silica) carry out combining and after adopting the proportioning of suitable dose, result of use is significantly better than independent glyceryl monolaurate, highly effective and safe more, can effectively improve piglet disease-resistant ability, promote piglet growth, better economic benefit can be obtained.
Embodiment 4
Experiment adopts single-factor design, the principle that, hereditary basis close according to body weight is similar, choose 28 age in days weanling pigs (male and female half and half) 300, be divided into 5 groups at random: processed group, control group D, control group E, control group F, control group G, often organize 3 repetitions, often repeat 20, to feed weanling pig with pig starter feed respectively, experimental period is 30 days.
(1) processed group: for antibiotic feed additive+feedstuff
Formula for antibiotic feed additive is: by weight percentage, glyceryl monolaurate 20%, dilaurate glyceride 30%, glycerin monostearate 30% and carrier (maltodextrin) 20%.
Be 0.1% for the addition of antibiotic feed additive in pig starter feed, namely the percetage by weight of glyceryl monolaurate in pig starter feed is 0.02%.
(2) control group D: for antibiotic feed additive+feedstuff
Be that the formula of embodiment 1 in the application for a patent for invention document of CN102696883A is as antibiotic feed additive with application publication number.
Being specially: by weight percentage, monoester content is the glyceryl monolaurate of 70%, the weight ratio of calcium propionate and feed vector (maltodextrin) is 3:2:5, is 0.1% for the addition of antibiotic feed additive in pig starter feed.
(3) control group E: for antibiotic feed additive+feedstuff
Using the mixture of glyceryl monolaurate, dilaurate glyceride, glycerin monostearate and carrier (maltodextrin) as antibiotic feed additive, the weight of glyceryl monolaurate is adjusted to 1/4 times (namely 0.005%) of processed group, and the addition of its each component in pig starter feed is identical with the addition of component each in processed group.
(4) control group F: for antibiotic feed additive+feedstuff
Using the mixture of glyceryl monolaurate, dilaurate glyceride, glycerin monostearate and carrier (maltodextrin) as antibiotic feed additive, the weight of glyceryl monolaurate is adjusted to 1.5 times (namely 0.03%) of processed group, and the addition of its each component in pig starter feed is identical with the addition of component each in processed group.
(5) control group G: for antibiotic feed additive+feedstuff
Using the mixture of glyceryl monolaurate, dilaurate glyceride, glycerin monostearate and carrier (maltodextrin) as antibiotic feed additive, the weight of glyceryl monolaurate is adjusted to 3 times (namely 0.06%) of processed group, and the addition of its each component in pig starter feed is identical with the addition of component each in processed group.
Data record and recruitment evaluation index (see table 5)
Table 5. weanling pig feeding effect
Note: data are all Mean ± SD, the lowercase of going together different representative has significant difference, P ﹤ 0.05.
As shown in Table 5, the daily gain of processed group and feed intake are significantly higher than control group D, improve 15.1% and 12.6% respectively, illustrating that the result of use of the feed addictive of processed group is significantly better than application publication number is formula in the application for a patent for invention document of CN102696883A, and obtained feed is more efficient, more effectively can improves piglet disease-resistant ability and promote piglet growth.The daily gain of processed group and feed intake are respectively than control group E, control group F and control group G improves 27.1% and 22.5%, 4.6% and 3.8%, 9.8% and 6.7%, feedstuff-meat ratio, death rate also obviously declines, glyceryl monolaurate in embodiment processed group feed addictive is described, dilaurate glyceride, the proportioning of glycerin monostearate must be suitable for, and the necessary reasonable and suitable of the consumption of glyceryl monolaurate, otherwise too high levels feed addictive can become puckery excessively strong with antibiosis and antiviral functions because of mouthfeel, less and the intestinal microflora imbalance to feed intake raising effect, daily gain is caused to reduce, and the too low feed addictive of content can be inadequate because of dosage, one protective barrier can not be constructed in enteron aisle, act on very micro-, to feed intake and daily gain raising effect less.
In a word, feed addictive of the present invention according to Optimum Contents and ratio composite, make an addition to pig starter feed, can partly measure or the use of full dose substitute antibiotics in piglet cultivation, there is the effect suppressing harmful bacteria the infringement of enteron aisle not to be caused again to gut flora extra-inhibitory, slow releasing laurate under gut flora and digestive ferment effect, little to GI irritation, and play energy supply continuously and healthily and inhibitory anti-virus effect, gut flora fermentation is stimulated to produce acetic acid, propionic acid, butyric acid, reduce the diseases such as grice diarrhoea, promote intestinal growth and function of intestinal canal perfect, improve the resistance against diseases of piglet, reduce P, improve survival rate, increase phagostimulating effect, enhancing development, improve fanning economics, reduce antibiotic usage, reduce environmental pollution.
Claims (10)
1. a feed addictive, is characterized in that, by weight percentage, comprising:
2. feed addictive as claimed in claim 1, is characterized in that, by weight percentage, comprising:
3. feed addictive as claimed in claim 1 or 2, it is characterized in that, described carrier is silica, maltodextrin or starch.
4. an animal feed, is characterized in that, containing, for example the arbitrary described feed addictive of claims 1 to 3.
5. animal feed as claimed in claim 4, it is characterized in that, by weight percentage, the addition of described feed addictive in animal feed is 0.05 ~ 0.3%.
6. animal feed as claimed in claim 5, it is characterized in that, described animal feed is pig feed.
7. animal feed as claimed in claim 5, it is characterized in that, described animal feed comprises feedstuff and described feed addictive; The formula of described feedstuff is: by weight percentage, corn 30.0 ~ 65.0%, wheat 9.0 ~ 14.0%, secondary powder 4.0 ~ 6.0%, dehulled soybean meal 16 ~ 20%, expanded soybean 6.0 ~ 8.0%, high lactose whey powder 10.0 ~ 14%, imported fish meal 3.0 ~ 6.0%, skimmed milk power 1.0 ~ 3.0%, premix 1.0 ~ 5.0%, stone flour 1.0 ~ 3.0%;
The nutritional labeling of described feedstuff is: by weight percentage, crude protein 16 ~ 23%, lysine 0.8 ~ 1.6%, methionine 0.5 ~ 0.8%, cystine 0.3 ~ 0.6%, threonine 0.8 ~ 1.2%, tryptophan 0.2 ~ 0.4%, total calcium 1.0 ~ 2.0%, total phosphorus 0.8 ~ 1.0%, available phosphorus 0.4 ~ 0.6%.
8. animal feed as claimed in claim 7, it is characterized in that, described animal feed is pig starter feed; The formula of described feedstuff is: by weight percentage, corn 36.0%, wheat 12.0%, secondary powder 5.0%, dehulled soybean meal 17.5%, expanded soybean 8.0%, high lactose whey powder 12.5%, imported fish meal 5.0%, skimmed milk power 2.0%, pig premix 1.0%, stone flour 1.0%;
The nutritional labeling of described feedstuff is: by weight percentage, crude protein 22%, lysine 1.4%, methionine 0.6%, cystine 0.4%, threonine 0.9%, tryptophan 0.3%, total calcium 1.0%, total phosphorus 0.85%, available phosphorus 0.5%.
9. a preparation method for animal feed, is characterized in that, adds in feedstuff by arbitrary for Claims 1 to 4 described feed addictive, by be uniformly mixed or extruder grain mode obtains animal feed.
10. the feed addictive as described in as arbitrary in claims 1 to 3 is as the application of Substitutes For Antibiotic in pig starter feed.
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