CN105396085A - Oral liquid prepared from unhatched egg extract and used for treating peptic ulcers - Google Patents

Abstract

The invention discloses oral liquid prepared from unhatched egg extract and used for treating peptic ulcers and relates to the technical field of traditional Chinese medicine preparation. The oral liquid is prepared from, by weight, 5-10 parts of live-birth unhatched egg extract, 8-13 parts of live-birth unhatched egg yolk powder, 25-30 parts of lalang grass rhizome, 20-25 parts of prunella vulgaris, 15-20 parts of black tea, 15-20 parts of milkvetch roots, 13-17 parts of lotus leaves, 10-15 parts of the root of kudzu vine, 10-15 parts of malt, 8-12 parts of auricularia auricular, 6-10 parts of bitter gourd seeds, 6-10 parts of shaddock peel, 5-8 parts of grape seeds, 5-8 parts of acerola cherries, 4-7 parts of black sesame, 3-5 parts of fresh ginger and 2-3 parts of garlic. The prepared oral liquid has the characteristics that the treatment effect is remarkable, and adopted materials are natural, and is free of any side effect and safe to take. In addition, by means of yolk in live-birth unhatched eggs, the nutritional ingredients of the oral liquid can be enriched.

Description

A kind of oral liquid of the treatment peptic ulcer utilizing mao egg extract to prepare

Technical field:

The present invention relates to Chinese drug preparation technique field, be specifically related to a kind of oral liquid of the treatment peptic ulcer utilizing mao egg extract to prepare.

Background technology:

Hair egg, i.e. hair egg, have two types.One is stillborn fetus hair egg, is fertile egg in 14 to 21 days of hatching, due to the dead chicken tire that humiture or antibacterial and parasitic infection cause.Another kind is fetal hair egg of living, and namely has a mind to when chicken hatches stop hatching, forms fetal hair egg of living, is also called pearl alive.Wherein in stillborn fetus hair egg except containing except escherichia coli, Bacillus typhi, staphylococcus, Bacillus proteus, Salmonella, may also have parasite and worm's ovum etc., edible meeting causes digestive tract disease.And fetal hair egg of living is edible, have the deliciousness of egg and Carnis Gallus domesticus concurrently, special taste.In addition, containing a certain amount of beneficial activity composition in fetal hair egg of living, after suitable technique is extracted, can be made into the medicine for prevention and therapy various diseases or health product.At present, the research about this one side almost has no report, is therefore necessary to further investigate, thus develops the product with prevention and therapy disease effect.

Summary of the invention:

Technical problem to be solved by this invention is to provide a kind of Be very effective and the oral liquid for the treatment of peptic ulcer prepared of the utilization hair egg extract had no side effect.

Technical problem to be solved by this invention adopts following technical scheme to realize:

An oral liquid for the treatment peptic ulcer utilizing mao egg extract to prepare, be made up of the raw material of following parts by weight:

Fetal hair egg extract 5-10 part alive, live fetal hair egg yolk powder 8-13 part, Rhizoma Imperatae 25-30 part, Spica Prunellae 20-25 part, black tea 15-20 part, Radix Astragali 15-20 part, Folium Nelumbinis 13-17 part, Radix Puerariae 10-15 part, Fructus Hordei Germinatus 10-15 part, Auricularia 8-12 part, bitter melon seed 6-10 part, pomelo peel 6-10 part, Semen Vitis viniferae 5-8 part, Malpighia glabra L. 5-8 part, Semen Sesami Nigrum 4-7 part, Rhizoma Zingiberis Recens 3-5 part, Bulbus Allii 2-3 part;

The preparation method of described fetal hair egg extract alive is: first shell work fetal hair egg egg yolk, residue distilled water immersion, twice water is changed in centre, each immersion 15min, then tiny bulk is become by crusher in crushing, and add 2-3 times amount distilled water and 0.5% times amount acetic acid, mixture is prior to supersonic frequency 40kHz, supersound process 30min under power 100W, again in microwave frequency 2450MHz, microwave treatment 15min under power 600W, filter, equivalent ethanol is added in filtrate, be uniformly mixed 10min, again filter, gained filtrate is prior to homogenizing 20min under 20MPa, pasteurize 30min at 68-70 DEG C again, powdery is ground into finally by after spraying dry,

The preparation method of described fetal hair egg yolk powder alive is: isolate egg yolk after first being shelled by work fetal hair egg, the distilled water rinsing three times of gained egg yolk, then under room temperature under 20MPa homogenizing 15min, pasteurize 30min at 68-70 DEG C again, send into vacuum drier subsequently, make powdery finally by pulverizer.

A preparation method for the oral liquid of the treatment peptic ulcer utilizing mao egg extract to prepare, comprises the following steps:

(1) first Rhizoma Imperatae, Radix Puerariae, Fructus Hordei Germinatus, bitter melon seed and Semen Vitis viniferae are added in 5 times of water gagings, to soak after 30min microwave treatment 15min under microwave frequency 2450MHz, power 600W, and then add Spica Prunellae, black tea, the Radix Astragali, Folium Nelumbinis and Auricularia, continue microwave treatment 10min, supersound process 30min under supersonic frequency 40kHz, power 100W subsequently, process terminates rear filtration, and gained filtrate is for subsequent use;

(2) 1/3 of the filtrate simmer down to original volume upper step obtained, add together with Bulbus Allii in fiberizer with fetal hair egg yolk powder of living, pomelo peel, Malpighia glabra L., Rhizoma Zingiberis Recens again, filter after abundant defibrination, the Semen Sesami Nigrum being ground into powder is added in gained filtrate, mix homogeneously post-heating is incubated 15min to fluidized state, finally add fetal hair egg extract alive, fully mix.

The invention has the beneficial effects as follows: the present invention with fetal hair egg extract of living for primary raw material, and be aided with the multiple Chinese medicine ingredients with treatment PEPTIC ULCER OF THE AGED effect, obtained oral liquid has evident in efficacy, that materials are natural feature, without any side effects, takes safety; The utilization of fetal hair egg mesolecithal alive, can enrich the nutritional labeling of oral liquid in addition.

Detailed description of the invention:

The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.

The preparation of fetal hair egg extract alive:

First shell work fetal hair egg egg yolk, residue distilled water immersion, twice water is changed in centre, each immersion 15min, then tiny bulk is become by crusher in crushing, and add 3 times amount distilled water and 0.5% times amount acetic acid, mixture is prior to supersonic frequency 40kHz, supersound process 30min under power 100W, again in microwave frequency 2450MHz, microwave treatment 15min under power 600W, filter, equivalent ethanol is added in filtrate, be uniformly mixed 10min, again filter, gained filtrate is prior to homogenizing 20min under 20MPa, pasteurize 30min at 68-70 DEG C again, powdery is ground into finally by after spraying dry.

The preparation of fetal hair egg yolk powder alive:

Isolate egg yolk after first being shelled by work fetal hair egg, the distilled water rinsing three times of gained egg yolk, then under room temperature under 20MPa homogenizing 15min, then at 68-70 DEG C pasteurize 30min, send into vacuum drier subsequently, make powdery finally by pulverizer.

Embodiment 1

(1) first 25 parts of Rhizoma Imperataes, 15 parts of Radix Puerariaes, 10 parts of Fructus Hordei Germinatus, 6 parts of bitter melon seeds and 5 parts of Semen Vitis viniferae are added in 5 times of water gagings, to soak after 30min microwave treatment 15min under microwave frequency 2450MHz, power 600W, and then add 20 parts of Spica Prunellaes, 16 parts of black tea, 15 portions of Radixs Astragali, 13 parts of Folium Nelumbinis and 9 portions of Auricularia, continue microwave treatment 10min, supersound process 30min under supersonic frequency 40kHz, power 100W subsequently, process terminates rear filtration, and gained filtrate is for subsequent use;

(2) 1/3 of the filtrate simmer down to original volume upper step obtained, fetal hair egg yolk powder alive with 10 parts, 7 portions of pomelo peels, 5 portions of Malpighia glabra L., 4 portions of Rhizoma Zingiberis Recenss add in fiberizer together with 2 portions of Bulbus Alliis again, filter after abundant defibrination, the 5 portions of Semen Sesami Nigrums being ground into powder are added in gained filtrate, mix homogeneously post-heating is incubated 15min to fluidized state, finally add 7 parts of fetal hair egg extracts alive, fully mix.

Embodiment 2

(1) first 28 parts of Rhizoma Imperataes, 13 parts of Radix Puerariaes, 12 parts of Fructus Hordei Germinatus, 8 parts of bitter melon seeds and 7 parts of Semen Vitis viniferae are added in 5 times of water gagings, to soak after 30min microwave treatment 15min under microwave frequency 2450MHz, power 600W, and then add 23 parts of Spica Prunellaes, 18 parts of black tea, 15 portions of Radixs Astragali, 15 parts of Folium Nelumbinis and 10 portions of Auricularia, continue microwave treatment 10min, supersound process 30min under supersonic frequency 40kHz, power 100W subsequently, process terminates rear filtration, and gained filtrate is for subsequent use;

(2) 1/3 of the filtrate simmer down to original volume upper step obtained, fetal hair egg yolk powder alive with 10 parts, 8 portions of pomelo peels, 7 portions of Malpighia glabra L., 4 portions of Rhizoma Zingiberis Recenss add in fiberizer together with 2 portions of Bulbus Alliis again, filter after abundant defibrination, the 6 portions of Semen Sesami Nigrums being ground into powder are added in gained filtrate, mix homogeneously post-heating is incubated 15min to fluidized state, finally add 8 parts of fetal hair egg extracts alive, fully mix.

Embodiment 3

(1) first 30 parts of Rhizoma Imperataes, 15 parts of Radix Puerariaes, 15 parts of Fructus Hordei Germinatus, 9 parts of bitter melon seeds and 7 parts of Semen Vitis viniferae are added in 5 times of water gagings, to soak after 30min microwave treatment 15min under microwave frequency 2450MHz, power 600W, and then add 25 parts of Spica Prunellaes, 20 parts of black tea, 15 portions of Radixs Astragali, 17 parts of Folium Nelumbinis and 10 portions of Auricularia, continue microwave treatment 10min, supersound process 30min under supersonic frequency 40kHz, power 100W subsequently, process terminates rear filtration, and gained filtrate is for subsequent use;

(2) 1/3 of the filtrate simmer down to original volume upper step obtained, fetal hair egg yolk powder alive with 13 parts, 10 portions of pomelo peels, 8 portions of Malpighia glabra L., 5 portions of Rhizoma Zingiberis Recenss add in fiberizer together with 3 portions of Bulbus Alliis again, filter after abundant defibrination, the 7 portions of Semen Sesami Nigrums being ground into powder are added in gained filtrate, mix homogeneously post-heating is incubated 15min to fluidized state, finally add 9 parts of fetal hair egg extracts alive, fully mix.

Animal toxicity test and effectiveness study are carried out to oral liquid of the present invention:

1, animal acute toxicity test

Subjects: white mice, body weight 18-22g, male and female half and half;

Test method: get white mice 50, be divided into 5 groups, often organize 10, wherein one group is blank group, and all the other four groups is test group, fasting 12h before test group administration, fills with and feeds oral liquid, fill with respectively and feed 1,2,3,4 time, fill with after feeding and observe 7 days in 24h by every only each 5ml;

Result of the test: test white mice is movable normal, non-toxic reaction, without dead.

2, long-term toxicity test for animals

Subjects: rat, body weight 120-150g, male and female half and half;

Test method: get rat 50, be divided into 5 groups, often organize 10, wherein one group is blank group, and all the other four groups is test group, test group fills with hello oral liquid 5ml, 10ml, 20ml, 30ml every day respectively, continuous irrigation is fed 90 days, monitoring body weight, 24h sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the change of tissues observed form;

Result of the test: test group activity is normal, non-toxic reaction, without dead, the every inspection after execution and blank group are without any difference.

3, effectiveness study

Object of study: select 100 patients suffering from peptic ulcer, wherein male 55, women 45;

Instructions of taking: each serving with this oral liquid 30mL, once a day, 30 days be a course for the treatment of.

Criterion of therapeutical effect: (1) cures: all transference cures, (2) are effective: partial symptoms is alleviated; (3) improve without any symptom.

Efficacy result: 56 examples are cured, effectively, 4 examples are invalid for 40 examples.

4, model case

Case 1: Lee, man, 50 years old, in more than 10 years of Huan Wei institute dull pain, every autumn and winter increased the weight of.Immediate cause is addicted to eating cool drink, stomachache attack, and on an empty stomach more so, obtain food slightly slow, desire for warm and being pressed, eructation, noisy pantothenic acid, stomach has succussion splash, and stool is first hard rear half congealed.Upper digestive tract barium is saturating and make film, and examines as stomach and duodenum complex ulcer, once takes Weisen-U, cimetidine is not healed.Take this oral liquid after 15 days symptom disappear completely, continue to take drug withdrawal after 20 days, follow up a case by regular visits to 2 years gun-hos.

Case 2: Wang, female, 43 years old, suffer from discontinuity vague epigastralgia more than 8 years, often season in spring and autumn, the pain increased, existing vague epigastralgia, time hungry, very, obtain food alleviation of pain, sore spot likes dim pain relieved by pressing to pain, abdominal distention belch, time general vomiting watery fluid, body is tired weak, the hands and feet being not warm, stool as pitch shape, day row 2-3 time.Take the pain disappearance after 7 days of this oral liquid, continue to take drug withdrawal after 20 days, follow up a case by regular visits to 2 years gun-hos.

Case 3: Huang, man, 45 years old, once suffered from duodenal bulbar ulcer, frequent gastral cavilty is had a pain, and is very on an empty stomach, also normal bitterly awake midnight.Take this oral liquid after 12 days symptom disappear completely, continue to take drug withdrawal after 20 days, follow up a case by regular visits to 2 years gun-hos.

More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.

Claims (2)

1. an oral liquid for the treatment peptic ulcer utilizing mao egg extract to prepare, is characterized in that, be made up of the raw material of following parts by weight:

Fetal hair egg extract 5-10 part alive, live fetal hair egg yolk powder 8-13 part, Rhizoma Imperatae 25-30 part, Spica Prunellae 20-25 part, black tea 15-20 part, Radix Astragali 15-20 part, Folium Nelumbinis 13-17 part, Radix Puerariae 10-15 part, Fructus Hordei Germinatus 10-15 part, Auricularia 8-12 part, bitter melon seed 6-10 part, pomelo peel 6-10 part, Semen Vitis viniferae 5-8 part, Malpighia glabra L. 5-8 part, Semen Sesami Nigrum 4-7 part, Rhizoma Zingiberis Recens 3-5 part, Bulbus Allii 2-3 part;

The preparation method of described fetal hair egg extract alive is: first shell work fetal hair egg egg yolk, residue distilled water immersion, twice water is changed in centre, each immersion 15min, then tiny bulk is become by crusher in crushing, and add 2-3 times amount distilled water and 0.5% times amount acetic acid, mixture is prior to supersonic frequency 40kHz, supersound process 30min under power 100W, again in microwave frequency 2450MHz, microwave treatment 15min under power 600W, filter, equivalent ethanol is added in filtrate, be uniformly mixed 10min, again filter, gained filtrate is prior to homogenizing 20min under 20MPa, pasteurize 30min at 68-70 DEG C again, powdery is ground into finally by after spraying dry,

The preparation method of described fetal hair egg yolk powder alive is: isolate egg yolk after first being shelled by work fetal hair egg, the distilled water rinsing three times of gained egg yolk, then under room temperature under 20MPa homogenizing 15min, pasteurize 30min at 68-70 DEG C again, send into vacuum drier subsequently, make powdery finally by pulverizer.

2. a preparation method for the oral liquid of the treatment peptic ulcer utilizing hair egg extract to prepare as claimed in claim 1, is characterized in that, comprise the following steps:

(1) first Rhizoma Imperatae, Radix Puerariae, Fructus Hordei Germinatus, bitter melon seed and Semen Vitis viniferae are added in 5 times of water gagings, to soak after 30min microwave treatment 15min under microwave frequency 2450MHz, power 600W, and then add Spica Prunellae, black tea, the Radix Astragali, Folium Nelumbinis and Auricularia, continue microwave treatment 10min, supersound process 30min under supersonic frequency 40kHz, power 100W subsequently, process terminates rear filtration, and gained filtrate is for subsequent use;

(2) 1/3 of the filtrate simmer down to original volume upper step obtained, add together with Bulbus Allii in fiberizer with fetal hair egg yolk powder of living, pomelo peel, Malpighia glabra L., Rhizoma Zingiberis Recens again, filter after abundant defibrination, the Semen Sesami Nigrum being ground into powder is added in gained filtrate, mix homogeneously post-heating is incubated 15min to fluidized state, finally add fetal hair egg extract alive, fully mix.