CN105395680B - It is a kind of to treat neurasthenic Chinese medicine composition and its preparation method and application - Google Patents
It is a kind of to treat neurasthenic Chinese medicine composition and its preparation method and application Download PDFInfo
- Publication number
- CN105395680B CN105395680B CN201511010189.3A CN201511010189A CN105395680B CN 105395680 B CN105395680 B CN 105395680B CN 201511010189 A CN201511010189 A CN 201511010189A CN 105395680 B CN105395680 B CN 105395680B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- bombyx batryticatus
- valerian
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/10—Bryophyta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/264—Aristolochia (Dutchman's pipe)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
Neurasthenic Chinese medicine composition is treated the invention discloses a kind of, is made of the raw material below according to parts by weight: 22-28 parts of rose rhodobryum herb, 10-15 parts of semen ziziphi spinosae, 5-9 parts of bombyx batryticatus, 3-6 parts of valerian, 5-9 parts of Hedge Prinsepia Nut, 9-14 parts of field pennycress, 11-17 parts, 4-8 parts of herba aristolochiae of label grass of Schisandra chinensis 8-12 Fen, pig.The present invention also provides the preparation method of the Chinese medicine composition and purposes.Chinese medicine composition prepared by the present invention is significant in efficacy to neurastheniac, control difficulty in relapse after healing, and it has no toxic side effect, cure rate is up to 72.7%, for total effective rate up to 95.5%, prescription is simple, herba aristolochiae and Hedge Prinsepia Nut and other drugs compatibility, and using the preparation method of the traditional chinese medicine composition of the invention, be conducive to enhance drug effect.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of neurasthenic Chinese medicine composition for the treatment of and preparation method thereof and use
On the way.
Background technique
Neurasthenia refers to due to being chronically under nervous and pressure, the easily excited and mental easily tired phenomenon of spirit occurs,
Be often accompanied by mood worry, irritability, sleep disturbance, muscle tone pain etc., these symptoms cannot be attributed to brain, physical disease and
Other mental diseases.Weight when light when symptom fluctuates, the course of disease mostly delay related with psychosocial factor.
Most scholars think that mental element is to cause neurasthenic main cause at present.It is all to cause the lasting nervous heart
Some factors of feelings and long-term intrapsychic conflict keep nervous activity process strong and persistently in tension, are more than nerve
Neurasthenia can occur for the tolerance limit of system tension.Such as over fatigue and cannot to rest be that excited process is excessively tight
?；Dissatisfied to present situation is then overstrain of inhibitory process；Often change living environment and inadaptable, central nervous system
The activity of system plays a leading role in body Activities.And corticocerebral nerve cell have quite high tolerance, one
As in the case of be not easy to cause neurasthenia or failure.After nervous mental labour, although producing fatigue, pause
It can restore after having a rest or sleeping, still, the nervous activity of strong tense situation, once surmount tenability limit, it is possible to it produces
Raw neurasthenia.
The quickening of today's society work and life rhythm, causes the pressure of people increasing, so that with nerve
Weak people is also more and more, this disease can not only largely effect on the mood of people, also will affect working efficiency.It mostly uses at present
Mode based on psychotherapy, supplemented by drug therapy, but therapeutic effect is often not satisfactory, incubation period is longer, and at present
Our people can't acceptable learning treatment completely mode, and drug therapy relies primarily on stabilization agent, hypnotic sedative dose etc., but
These drugs existing defects in terms of safety and dependence, side effect is bigger, additive, drug resistance easy to form, therefore not
Preferably take for long periods of time.
Summary of the invention
Neurasthenic Chinese medicine composition and preparation method thereof is treated the purpose of the present invention is to provide a kind of, on solving
State the problem of proposing in background technique.
To achieve the above object, the invention provides the following technical scheme:
It is a kind of to treat neurasthenic Chinese medicine composition, it is made of the raw material below according to parts by weight: rose rhodobryum herb 22-28
Part, 10-15 parts of semen ziziphi spinosae, 5-9 parts of bombyx batryticatus, 3-6 parts of valerian, 5-9 parts of Hedge Prinsepia Nut, 9-14 parts of field pennycress, Schisandra chinensis 8-12 Fen, pig label
It is 11-17 parts careless, 4-8 parts of herba aristolochiae.
As a further solution of the present invention: being made of the raw material below according to parts by weight: 23-27 parts of rose rhodobryum herb, wild jujube
11-14 parts of benevolence, 6-8 parts of bombyx batryticatus, 4-5 parts of valerian, 6-8 parts of Hedge Prinsepia Nut, 10-13 parts of field pennycress, Schisandra chinensis 9-11 Fen, pig label grass 12-
16 parts, 5-7 parts of herba aristolochiae.
As further scheme of the invention: being made of the raw material below according to parts by weight: 25 parts of rose rhodobryum herb, semen ziziphi spinosae
13 parts, 7 parts of bombyx batryticatus, 5 parts of valerian, 7 parts of Hedge Prinsepia Nut, 12 parts of field pennycress, 14 parts, 6 parts of herba aristolochiae of grass of 10 Fen, pig label of Schisandra chinensis.
The preparation method of the neurasthenic Chinese medicine composition for the treatment of, steps are as follows:
1) rose rhodobryum herb, semen ziziphi spinosae, Hedge Prinsepia Nut, pig label grass are weighed, is cleaned, drying after grinding, is put into container, and 10-12 is added
The edible alcohol of amount, heating and refluxing extraction 3-4h obtain an extracting solution and a residue, an extracting solution are collected, by one again
The 6-8 times of edible alcohol measured is added in secondary residue again, and heating and refluxing extraction 1-2h obtains secondary raffinate and secondary residual, receives
Collect secondary raffinate, an extracting solution and secondary raffinate are merged, filtering obtains reflux extracting liquid, spare；
2) valerian, field pennycress, Schisandra chinensis and herba aristolochiae are weighed, is cleaned, drying after grinding, is put into container, and 8-12 is added
The edible alcohol of amount again, ultrasonic wave extraction 40-60 minutes, filtering obtained ultrasonic extract, spare；
3) bombyx batryticatus is weighed, stir-frying crushes as smalls to yellowish, spare；
4) reflux extracting liquid and ultrasonic extract are mixed, is concentrated under reduced pressure at 60 DEG C -70 DEG C, obtain dried cream powder；
5) dried cream powder is uniformly mixed with bombyx batryticatus smalls, capsule is made to get neurasthenic Chinese medicine composition is treated.
Above-mentioned Chinese medicine composition is used to prepare the neurasthenic drug for the treatment of.
Compared with prior art, the beneficial effects of the present invention are: Chinese medicine composition prepared by the present invention suffers from neurasthenia
Person is significant in efficacy, controls difficulty in relapse after healing, and have no toxic side effect, and cure rate is up to 72.7%, and total effective rate is up to 95.5%.The present invention
The Chinese medicine composition prescription of preparation is simple, herba aristolochiae and Hedge Prinsepia Nut and other drugs compatibility, and using the traditional chinese medicine composition of the invention
Preparation method is conducive to enhance drug effect.
Specific embodiment
Technical solution of the present invention is described in more detail With reference to embodiment.
Embodiment 1
It is a kind of to treat neurasthenic Chinese medicine composition, it is made of the raw material below according to parts by weight: 28 parts of rose rhodobryum herb, acid
15 parts of jujube kernel, 9 parts of bombyx batryticatus, 6 parts of valerian, 9 parts of Hedge Prinsepia Nut, 14 parts of field pennycress, 17 parts, 8 parts of herba aristolochiae of grass of 12 Fen, pig label of Schisandra chinensis.
The preparation method of the neurasthenic Chinese medicine composition for the treatment of described in the present embodiment, steps are as follows:
1) rose rhodobryum herb, semen ziziphi spinosae, Hedge Prinsepia Nut, pig label grass are weighed, is cleaned, drying after grinding, is put into container, is added 12 times
The edible alcohol of amount, heating and refluxing extraction 4h obtain an extracting solution and a residue, collect an extracting solution, will be primary residual
The edible alcohol of 8 times of amounts is added in slag again, and heating and refluxing extraction 2h obtains secondary raffinate and secondary residual, collects secondary mention
Liquid is taken, an extracting solution and secondary raffinate are merged, filtering obtains reflux extracting liquid, spare；
2) valerian, field pennycress, Schisandra chinensis and herba aristolochiae are weighed, is cleaned, drying after grinding, is put into container, is added 12 times
The edible alcohol of amount, ultrasonic wave extraction 60 minutes, filtering obtained ultrasonic extract, spare；
3) bombyx batryticatus is weighed, stir-frying crushes as smalls to yellowish, spare；
4) reflux extracting liquid and ultrasonic extract are mixed, is concentrated under reduced pressure at 70 DEG C, obtain dried cream powder；
5) dried cream powder is uniformly mixed with bombyx batryticatus smalls, capsule is made to get neurasthenic Chinese medicine composition is treated.
Embodiment 2
It is a kind of to treat neurasthenic Chinese medicine composition, it is made of the raw material below according to parts by weight: 22 parts of rose rhodobryum herb, acid
10 parts of jujube kernel, 5 parts of bombyx batryticatus, 3 parts of valerian, 5 parts of Hedge Prinsepia Nut, 9 parts of field pennycress, 11 parts, 4 parts of herba aristolochiae of grass of 8 Fen, pig label of Schisandra chinensis.
The preparation method of the neurasthenic Chinese medicine composition for the treatment of described in the present embodiment, steps are as follows:
1) rose rhodobryum herb, semen ziziphi spinosae, Hedge Prinsepia Nut, pig label grass are weighed, is cleaned, drying after grinding, is put into container, is added 10 times
The edible alcohol of amount, heating and refluxing extraction 4h obtain an extracting solution and a residue, collect an extracting solution, will be primary residual
The edible alcohol of 7 times of amounts is added in slag again, and heating and refluxing extraction 2h obtains secondary raffinate and secondary residual, collects secondary mention
Liquid is taken, an extracting solution and secondary raffinate are merged, filtering obtains reflux extracting liquid, spare；
2) valerian, field pennycress, Schisandra chinensis and herba aristolochiae are weighed, is cleaned, drying after grinding, is put into container, is added 11 times
The edible alcohol of amount, ultrasonic wave extraction 50 minutes, filtering obtained ultrasonic extract, spare；
3) bombyx batryticatus is weighed, stir-frying crushes as smalls to yellowish, spare；
4) reflux extracting liquid and ultrasonic extract are mixed, is concentrated under reduced pressure at 65 DEG C, obtain dried cream powder；
5) dried cream powder is uniformly mixed with bombyx batryticatus smalls, capsule is made to get neurasthenic Chinese medicine composition is treated.
Embodiment 3
It is a kind of to treat neurasthenic Chinese medicine composition, it is made of the raw material below according to parts by weight: 25 parts of rose rhodobryum herb, acid
13 parts of jujube kernel, 7 parts of bombyx batryticatus, 5 parts of valerian, 7 parts of Hedge Prinsepia Nut, 12 parts of field pennycress, 14 parts, 6 parts of herba aristolochiae of grass of 10 Fen, pig label of Schisandra chinensis.
The preparation method of the neurasthenic Chinese medicine composition for the treatment of described in the present embodiment, steps are as follows:
1) rose rhodobryum herb, semen ziziphi spinosae, Hedge Prinsepia Nut, pig label grass are weighed, is cleaned, drying after grinding, is put into container, is added 11 times
The edible alcohol of amount, heating and refluxing extraction 3.5h obtain an extracting solution and a residue, collect an extracting solution, will be primary
The edible alcohol of 7 times of amounts is added in residue again, and heating and refluxing extraction 1.5h obtains secondary raffinate and secondary residual, collects two
Secondary extracting solution merges an extracting solution and secondary raffinate, filtering, obtains reflux extracting liquid, spare；
2) valerian, field pennycress, Schisandra chinensis and herba aristolochiae are weighed, is cleaned, drying after grinding, is put into container, is added 10 times
The edible alcohol of amount, ultrasonic wave extraction 50 minutes, filtering obtained ultrasonic extract, spare；
3) bombyx batryticatus is weighed, stir-frying crushes as smalls to yellowish, spare；
4) reflux extracting liquid and ultrasonic extract are mixed, is concentrated under reduced pressure at 65 DEG C, obtain dried cream powder；
5) dried cream powder is uniformly mixed with bombyx batryticatus smalls, capsule is made to get neurasthenic Chinese medicine composition is treated.
Embodiment 4
It is a kind of to treat neurasthenic Chinese medicine composition, it is made of the raw material below according to parts by weight: 23 parts of rose rhodobryum herb, acid
14 parts of jujube kernel, 8 parts of bombyx batryticatus, 5 parts of valerian, 6 parts of Hedge Prinsepia Nut, 14 parts of field pennycress, 13 parts, 7 parts of herba aristolochiae of grass of 12 Fen, pig label of Schisandra chinensis.
The preparation method of the neurasthenic Chinese medicine composition for the treatment of described in the present embodiment, steps are as follows:
1) rose rhodobryum herb, semen ziziphi spinosae, Hedge Prinsepia Nut, pig label grass are weighed, is cleaned, drying after grinding, is put into container, is added 10 times
The edible alcohol of amount, heating and refluxing extraction 3h obtain an extracting solution and a residue, collect an extracting solution, will be primary residual
The edible alcohol of 6 times of amounts is added in slag again, and heating and refluxing extraction 1h obtains secondary raffinate and secondary residual, collects secondary mention
Liquid is taken, an extracting solution and secondary raffinate are merged, filtering obtains reflux extracting liquid, spare；
2) valerian, field pennycress, Schisandra chinensis and herba aristolochiae are weighed, is cleaned, drying after grinding, is put into container, is added 8 times
The edible alcohol of amount, ultrasonic wave extraction 40 minutes, filtering obtained ultrasonic extract, spare；
3) bombyx batryticatus is weighed, stir-frying crushes as smalls to yellowish, spare；
4) reflux extracting liquid and ultrasonic extract are mixed, is concentrated under reduced pressure at 60 DEG C, obtain dried cream powder；
5) dried cream powder is uniformly mixed with bombyx batryticatus smalls, capsule is made to get neurasthenic Chinese medicine composition is treated.
Embodiment 5
It is a kind of to treat neurasthenic Chinese medicine composition, it is made of the raw material below according to parts by weight: 24 parts of rose rhodobryum herb, acid
15 parts of jujube kernel, 6 parts of bombyx batryticatus, 6 parts of valerian, 9 parts of Hedge Prinsepia Nut, 12 parts of field pennycress, 12 parts, 7 parts of herba aristolochiae of grass of 11 Fen, pig label of Schisandra chinensis.
The preparation method of the neurasthenic Chinese medicine composition for the treatment of described in the present embodiment, steps are as follows:
1) rose rhodobryum herb, semen ziziphi spinosae, Hedge Prinsepia Nut, pig label grass are weighed, is cleaned, drying after grinding, is put into container, is added 12 times
The edible alcohol of amount, heating and refluxing extraction 3h obtain an extracting solution and a residue, collect an extracting solution, will be primary residual
The edible alcohol of 7 times of amounts is added in slag again, and heating and refluxing extraction 2h obtains secondary raffinate and secondary residual, collects secondary mention
Liquid is taken, an extracting solution and secondary raffinate are merged, filtering obtains reflux extracting liquid, spare；
2) valerian, field pennycress, Schisandra chinensis and herba aristolochiae are weighed, is cleaned, drying after grinding, is put into container, is added 9 times
The edible alcohol of amount, ultrasonic wave extraction 60 minutes, filtering obtained ultrasonic extract, spare；
3) bombyx batryticatus is weighed, stir-frying crushes as smalls to yellowish, spare；
4) reflux extracting liquid and ultrasonic extract are mixed, is concentrated under reduced pressure at 63 DEG C, obtain dried cream powder；
5) dried cream powder is uniformly mixed with bombyx batryticatus smalls, capsule is made to get neurasthenic Chinese medicine composition is treated.
Comparative example 1
25 parts of rose rhodobryum herb, 13 parts of semen ziziphi spinosae, 7 parts of bombyx batryticatus, 5 parts of valerian, 7 parts of Hedge Prinsepia Nut, field pennycress 12 are weighed according to parts by weight
Part, 14 parts of grass of 10 Fen, pig label of Schisandra chinensis.Decoct patent medicine soup.
Comparative example 2
25 parts of rose rhodobryum herb, 13 parts of semen ziziphi spinosae, 7 parts of bombyx batryticatus, 5 parts of valerian, 12 parts of field pennycress, Schisandra chinensis are weighed according to parts by weight
10 14 parts, 6 parts of herba aristolochiae of grass of Fen, pig label.Decoct patent medicine soup.
Drug test
One, acute toxicity testing:
Mouse 50 are randomly selected, half male and half female, weight 16-25g carries out acute toxicity test.
Mouse is randomly divided into two groups, i.e. control group and administration group, fasting 12 hours before testing, by the embodiment of the present invention 3
The capsule of preparation is dissolved in water, and (concentration is 5.36g crude drug/ml, maximum concentration) carries out stomach-filling to administration group mouse, and stomach-filling is held
Product is 5ml/kg (i.e. unit dosage form is 26.8 crude drugs/kg), and control group gives same amount of normal saline, is administered 2 times within one day, gives
It medicine interval time 6 hours, is observed continuously after administration 14 days, and records the toxic reaction and death toll of mouse.
The results showed that compared with the control group, administration group mouse has no notable difference, and experiment is observed continuously 14 days, small
Mouse body condition, diet, drinking water and weight gain is normal.The Mouse oral stomach-filling crude drug of tablet, that is, LD50 > 26.8 of the invention/
Kg, daily maximum dosage-feeding are 53.6 crude drugs/kg/ days.Chinese medicine clinical dosage of the invention is 5.8g crude drug/day/people, adult
For weight in terms of 60KG, average dosage is 0.097g crude drug/kg/ days.By batheroom scale: mouse (average weight is in terms of 21g) mouth
The dosis tolerata for taking stomach-filling Chinese medicine of the invention is 552 times of quantity.Therefore middle acute toxicity of the invention is extremely low, clinical
Drug safety.
Two, long term toxicity test:
Mouse 50 are randomly selected, half male and half female, weight 18-26g carries out long term toxicity test.
Mouse is randomly divided into two groups, i.e. control group and administration group, and administration group uses the capsule solution of the embodiment of the present invention 3
Stomach-filling is carried out, 26.8g crude drug/kg (1.Oml/100g weight, 2 times a day), control group gives same amount of normal saline, continuous use
15 weeks, and be discontinued 3 weeks.
The result shows that: administration group is compared with the control group without significant changes, the hair of Chinese medicine composition of the invention to mouse
The indexs such as hair, behavior, stool and urine, weight, organ weights, blood picture, hepatic and renal function, blood glucose, blood lipid all have no significant effect, internal organs meat
After eye is without finding that abnormal variation and histological indications show medication 15 weeks and be discontinued 3 weeks, Organs of Mice is without obvious
Change.Illustrate the traditional chinese medicine composition of the invention to small toxicity after mouse long-term administration, also without abnormal reaction after drug withdrawal, therefore the medicine
Object is safe and non-toxic.
Three, clinical test
1, choose make a definite diagnosis neurastheniac 132, the age at 20-56 years old, the course of disease between-four years 3 months,
132 neurastheniacs are randomly divided into three groups, respectively two groups, every group 44 for the treatment of group, one group of control and control.
Two groups for the treatment of group, one group of control and control, the age of this three groups of cases, the course of disease, degrees of symptoms are almost the same,
No significant difference is comparable.
2, diagnostic criteria
It is formulated according to diagnostic criteria neurasthenic in " neurology ".
(1) debilitating symptoms: such as metal fatigue, mental retardation, attention is difficult to concentrate, memory difficulty, and work or study are not
It can lasting, efficiency reduction.
(2) Agitation: work or study brain can cause mental excitation；Recall and association increases, loses control of；It can
It is sensitive to acousto-optic；But it and does not appear as speech movement and increases.
(3) emotional symptoms: easily worried, Yi Ji, also can express work, learning efficiency decline or it is deficient in energy and anxious,
Worries, but it is droning without the unknown mental state of extensive anxiety or reason.
(4) tonicity pain: such as tension headache, tonic muscle pain.
(5) sleep disturbance: such as difficulty falling asleep, dreaminess, Yi Xing, wake up after do not recover from fatigue.
When at least having three in above five, diagnosable is neurasthenia.
Exclusion criteria: merge personality disorder person；Less than 3 months persons of the course of disease；Physical disease or brain structural disease become；In drug
Poison；Post-traumatic brain syndrome；The comprehensive card of fatigue；Adapt to reaction；The mental patients such as schizophrenia, depression and other nerves
Symptom obstacle；Person caused by physiological barrier caused by psychological factor or external environment；It is tight to merge severe cardiac, liver, kidney and hemopoietic system
Weight primary disease；Gestation or breast feeding women.
3, medicament selection
The Chinese medicinal composition capsules obtained of the embodiment of the present invention 3 are taken by treatment group, take orally, three times a day, two every time,
20-day courses.
It compares one group and takes medicine soup, one dose per day obtained by comparative example 1 and be taken in two divided doses, 20-day courses.
It compares two groups and takes medicine soup, one dose per day obtained by comparative example 2 and be taken in two divided doses, 20-day courses.
4, curative effect determinate standard
Cure: body and mental symptom disappearance or substantially reduced, sleeping time restores normal or Nighttime sleep is in 6h
More than, work, learning efficiency restore normal.
Effective: body and mental symptom improve, and sleep improves, and sleeping time obviously mentions in 4-6h, work, learning efficiency
Height can be engaged in general mental and physical exertion.
Invalid: body and mental symptom are unchanged or aggravate, and sleeping time less than 4h or without improvement, can not be engaged in general
Mental and physical exertion.
5, treatment results
Two groups for the treatment of group, one group of control and control carry out the treatment of two courses for the treatment of.Treatment results are as follows
Treatment group: totally 44, healing 32, effective 10, invalid 2, cure rate 72.7%, total effective rate 95.5%.
Compare one group: totally 44, healing 26, effective 12, invalid 6, cure rate 59.1%, total effective rate
86.4%.
Compare two groups: totally 44, healing 24, effective 13, invalid 7, cure rate 54.5%, total effective rate
84.1%.
As can be seen that Chinese medicine composition prepared by the present invention is significant in efficacy to neurastheniac from treatment results, and
It has no toxic side effect, cure rate is up to 72.7%, and total effective rate is up to 95.5%.
In addition, the therapeutic effect for the treatment of group, better than two groups of one group of control and control, treatment group uses 3 institute of the embodiment of the present invention
The Chinese medicinal composition capsules of acquisition, one group of drug taken of control compared with Example 3, are free of herba aristolochiae, and using conventional
Decoction, two groups of drugs taken of control compared with Example 3, are free of Hedge Prinsepia Nut, and using conventional decoction.Due to treatment group
Therapeutic effect better than two groups of one group of control and control, therefore, it can be seen that herba aristolochiae and Hedge Prinsepia Nut and other drugs compatibility, and adopt
With the preparation method of the traditional chinese medicine composition of the invention, be conducive to enhance drug effect.
6, typical case
Case 1, Mr. Wang, male, 36 years old, there are the diseases such as dizziness, failure of memory in long campaigns mental labour before half a year
Shape, easily worried once in a while with headache, work decline, poor sleeping quality does not recover from fatigue after waking up, is diagnosed as neurasthenia.Take this hair
Capsule prepared by bright embodiment 3, after a course for the treatment of, symptom is mitigated, and is continued taking the two courses, and is fully recovered, after half a year with
It visits without recurrence.
Case 2, Zhang, female, 42 years old, due to operating pressure cause greatly it is absent minded, and often occur insomnia and dreamful sleep,
The symptoms such as Yi Xing, have seriously affected working efficiency.Once hypnotic is taken, symptom is alleviated, and recurs immediately once being discontinued.It makes a definite diagnosis
For neurasthenia.Take capsule prepared by the embodiment of the present invention 3, after two courses for the treatment of, symptom is substantially reduced, continues to take two
The course for the treatment of, recovery from illness, follow-up is without recurrence after half a year.
Case 3, Sui, male, 46 years old, the private entrepreneur, for the fatigue of hurrying back and forth for a long time that works, appearance in nearest five months was dizzy
Dim eyesight, nocturnal insomnia, daytime is listless, and attention can not be concentrated, loss of appetite, and with tension headache.It is diagnosed as mind
Through weak.Take capsule prepared by the embodiment of the present invention 3, after a course for the treatment of, symptom is mitigated, and continues to take three treatments
Journey, recovery from illness, follow-up is without recurrence after half a year.
Better embodiment of the invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be without departing from the purpose of the present invention
Various changes can be made.
Claims (4)
1. a kind of treat neurasthenic Chinese medicine composition, which is characterized in that be made of the raw material below according to parts by weight: Hui Xin
22-28 parts careless, 10-15 parts of semen ziziphi spinosae, 5-9 parts of bombyx batryticatus, 3-6 parts of valerian, 5-9 parts of Hedge Prinsepia Nut, 9-14 parts of field pennycress, Schisandra chinensis 8-12
11-17 parts, 4-8 parts of herba aristolochiae of Fen, pig label grass；
The preparation method of the neurasthenic Chinese medicine composition for the treatment of, steps are as follows:
1) rose rhodobryum herb, semen ziziphi spinosae, Hedge Prinsepia Nut, pig label grass are weighed, is cleaned, drying after grinding, is put into container, is added 10-12 times and is measured
Edible alcohol, heating and refluxing extraction 3-4h obtains an extracting solution and a residue, collects an extracting solution, will be primary residual
The 6-8 times of edible alcohol measured is added in slag again, and heating and refluxing extraction 1-2h obtains secondary raffinate and secondary residual, collects two
Secondary extracting solution merges an extracting solution and secondary raffinate, filtering, obtains reflux extracting liquid, spare；
2) valerian, field pennycress, Schisandra chinensis and herba aristolochiae are weighed, is cleaned, drying after grinding, is put into container, is added 8-12 times and is measured
Edible alcohol, ultrasonic wave extraction 40-60 minutes, filtering, obtain ultrasonic extract, it is spare；
3) bombyx batryticatus is weighed, stir-frying crushes as smalls to yellowish, spare；
4) reflux extracting liquid and ultrasonic extract are mixed, is concentrated under reduced pressure at 60 DEG C -70 DEG C, obtain dried cream powder；
5) dried cream powder is uniformly mixed with bombyx batryticatus smalls, capsule is made to get neurasthenic Chinese medicine composition is treated.
2. the neurasthenic Chinese medicine composition for the treatment of according to claim 1, which is characterized in that by below according to parts by weight
Raw material composition: 23-27 parts of rose rhodobryum herb, 11-14 parts of semen ziziphi spinosae, 6-8 parts of bombyx batryticatus, 4-5 parts of valerian, 6-8 parts of Hedge Prinsepia Nut, field pennycress
10-13 parts, 12-16 parts, 5-7 parts of herba aristolochiae of label grass of Schisandra chinensis 9-11 Fen, pig.
3. the neurasthenic Chinese medicine composition for the treatment of according to claim 2, which is characterized in that by below according to parts by weight
Raw material composition: 25 parts of rose rhodobryum herb, 13 parts of semen ziziphi spinosae, 7 parts of bombyx batryticatus, 5 parts of valerian, 7 parts of Hedge Prinsepia Nut, 12 parts of field pennycress, Schisandra chinensis 10
14 parts, 6 parts of herba aristolochiae of grass of Fen, pig label.
4. purposes of the Chinese medicine composition a method according to any one of claims 1-3 in preparation treatment neurasthenia drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511010189.3A CN105395680B (en) | 2015-12-29 | 2015-12-29 | It is a kind of to treat neurasthenic Chinese medicine composition and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511010189.3A CN105395680B (en) | 2015-12-29 | 2015-12-29 | It is a kind of to treat neurasthenic Chinese medicine composition and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105395680A CN105395680A (en) | 2016-03-16 |
| CN105395680B true CN105395680B (en) | 2019-09-17 |
Family
ID=55461675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201511010189.3A Expired - Fee Related CN105395680B (en) | 2015-12-29 | 2015-12-29 | It is a kind of to treat neurasthenic Chinese medicine composition and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105395680B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903250A (en) * | 2005-07-29 | 2007-01-31 | 天津天士力现代中药研究开发有限公司 | Method for extraction and separation of red rooted salvia |
| CN103536854A (en) * | 2013-10-26 | 2014-01-29 | 王永妍 | Traditional Chinese medicine composition capable of effectively treating neurasthenia, and preparation method thereof |
| CN104383272A (en) * | 2014-12-11 | 2015-03-04 | 谭清平 | Traditional Chinese medicine preparation used for treating diabetes |
| CN104771524A (en) * | 2015-04-22 | 2015-07-15 | 秦文官 | Traditional Chinese medicine composition for treating neurasthenia and preparation method of traditional Chinese medicine composition |
-
2015
- 2015-12-29 CN CN201511010189.3A patent/CN105395680B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903250A (en) * | 2005-07-29 | 2007-01-31 | 天津天士力现代中药研究开发有限公司 | Method for extraction and separation of red rooted salvia |
| CN103536854A (en) * | 2013-10-26 | 2014-01-29 | 王永妍 | Traditional Chinese medicine composition capable of effectively treating neurasthenia, and preparation method thereof |
| CN104383272A (en) * | 2014-12-11 | 2015-03-04 | 谭清平 | Traditional Chinese medicine preparation used for treating diabetes |
| CN104771524A (en) * | 2015-04-22 | 2015-07-15 | 秦文官 | Traditional Chinese medicine composition for treating neurasthenia and preparation method of traditional Chinese medicine composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105395680A (en) | 2016-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102771791A (en) | Healthcare food and preparation method and application thereof | |
| CN105725211A (en) | Food health product for improving sleep and preparation method thereof | |
| CN101637265B (en) | Health food used for improving sleeping | |
| CN102228617B (en) | Medicinal composition for treating insomnia | |
| CN102357195B (en) | Medicinal composition for treating cardiovascular and cerebrovascular diseases, and preparation method and application thereof | |
| CN103705774A (en) | Compound composition with effect of treating depression as well as preparation method and application thereof | |
| CN104223073B (en) | A kind of food, health products or pharmaceutical composition of sleeping | |
| CN107320674A (en) | A kind of Chinese medicine composition and its application | |
| CN100515486C (en) | Medicine for treating senile dementia and its preparing process | |
| CN105395680B (en) | It is a kind of to treat neurasthenic Chinese medicine composition and its preparation method and application | |
| CN105147796B (en) | A kind of Chinese medicine for treating type insomnia of having a guilty consicence | |
| CN109464451B (en) | Medicine for treating neurasthenia and preparation method thereof | |
| CN108938764A (en) | It is a kind of to have effects that alleviate Chinese medicine composition of autonomic nervous dysfunction and preparation method thereof and product | |
| CN103550671B (en) | The application of precious imperial refreshment medicine compositions in preparation treatment diabetic peripheral neuropathy medicine | |
| CN101559139A (en) | Prescription of pure traditional Chinese medicine preparation for preventing and curing neurasthenia insomnia and preparation method thereof | |
| CN100998744A (en) | Chinese patent drug for treating infantile hyperkinetic syndrome | |
| CN101244066B (en) | New purpose of total steroidal saponin extract | |
| CN110339323A (en) | A kind of Chinese medicine composition and its preparation method and application for treating bradycardia | |
| CN106581362A (en) | Chinese patent medicine for treatment of neurasthenia and preparation method thereof | |
| CN104095938A (en) | Mongolian medicine preparation for treating depression | |
| CN103638461B (en) | Treatment anxiety neurosis's medicine pill | |
| CN106924527A (en) | It is a kind of for medicine that is antifatigue, improving the health care of sleep food and preparation method thereof | |
| CN106668282A (en) | Application of heart-invigorating and calming tablet in preparation of medicine for curing heart diseases | |
| CN107441166A (en) | Application of the cinnamon oil in treatment behavior despair antidepressant agents are prepared | |
| CN100571722C (en) | Treatment is suffered from a deficiency of the kidney and the pharmaceutical composition of climacteric syndrome and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Yu Yang Inventor after: Liu Ke Inventor before: Liu Ke |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20190822 Address after: 400050 Chongqing Jiulongpo District Gaomiao Village Rongding New Court C Building 17-9 Applicant after: Yu Yang Address before: 236600 Fuyang Province Taihe County, Miao old town, the village of Yang Liu Miao temple, No. 30, No. 1 in the city of Anhui Applicant before: Liu Ke |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190917 Termination date: 20201229 |