CN105394354A - 受保护的α-淀粉酶 - Google Patents
受保护的α-淀粉酶 Download PDFInfo
- Publication number
- CN105394354A CN105394354A CN201510537496.0A CN201510537496A CN105394354A CN 105394354 A CN105394354 A CN 105394354A CN 201510537496 A CN201510537496 A CN 201510537496A CN 105394354 A CN105394354 A CN 105394354A
- Authority
- CN
- China
- Prior art keywords
- ams
- shielded
- amylase
- release
- feed ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000637 alpha-Amylases Proteins 0.000 title description 12
- 102000004139 alpha-Amylases Human genes 0.000 title description 12
- 229940024171 alpha-amylase Drugs 0.000 title description 12
- 238000000034 method Methods 0.000 claims description 82
- 239000000203 mixture Substances 0.000 claims description 33
- 229920002472 Starch Polymers 0.000 claims description 30
- 239000008107 starch Substances 0.000 claims description 30
- 235000019698 starch Nutrition 0.000 claims description 30
- 229920000642 polymer Polymers 0.000 claims description 23
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 22
- 241001465754 Metazoa Species 0.000 claims description 20
- 210000002784 stomach Anatomy 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 12
- 230000029087 digestion Effects 0.000 claims description 9
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 6
- 239000008116 calcium stearate Substances 0.000 claims description 6
- 235000013539 calcium stearate Nutrition 0.000 claims description 6
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 6
- 239000008118 PEG 6000 Substances 0.000 claims description 5
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims description 5
- 210000000936 intestine Anatomy 0.000 claims description 5
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
- 229920000193 polymethacrylate Polymers 0.000 claims description 4
- 239000001069 triethyl citrate Substances 0.000 claims description 4
- 235000013769 triethyl citrate Nutrition 0.000 claims description 4
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 230000002496 gastric effect Effects 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims 11
- 239000004382 Amylase Substances 0.000 abstract description 31
- 239000002253 acid Substances 0.000 abstract description 21
- 239000000463 material Substances 0.000 abstract description 16
- 239000004367 Lipase Substances 0.000 abstract description 12
- 102000004882 Lipase Human genes 0.000 abstract description 12
- 108090001060 Lipase Proteins 0.000 abstract description 12
- 108010019160 Pancreatin Proteins 0.000 abstract description 12
- 235000019421 lipase Nutrition 0.000 abstract description 12
- 229940055695 pancreatin Drugs 0.000 abstract description 12
- 230000002779 inactivation Effects 0.000 abstract description 9
- 238000011282 treatment Methods 0.000 abstract description 9
- 238000005516 engineering process Methods 0.000 abstract description 3
- 238000005538 encapsulation Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000005453 pelletization Methods 0.000 abstract 1
- 230000008569 process Effects 0.000 description 51
- 102000004190 Enzymes Human genes 0.000 description 48
- 108090000790 Enzymes Proteins 0.000 description 48
- 229940088598 enzyme Drugs 0.000 description 48
- 230000000694 effects Effects 0.000 description 40
- 238000012360 testing method Methods 0.000 description 39
- 230000002354 daily effect Effects 0.000 description 37
- 235000000346 sugar Nutrition 0.000 description 36
- 238000002474 experimental method Methods 0.000 description 34
- 241000287828 Gallus gallus Species 0.000 description 33
- 241001071864 Lethrinus laticaudis Species 0.000 description 31
- 230000012010 growth Effects 0.000 description 26
- 102000013142 Amylases Human genes 0.000 description 23
- 108010065511 Amylases Proteins 0.000 description 23
- 235000019418 amylase Nutrition 0.000 description 23
- 238000002360 preparation method Methods 0.000 description 20
- 235000019621 digestibility Nutrition 0.000 description 19
- 239000000047 product Substances 0.000 description 19
- 210000000813 small intestine Anatomy 0.000 description 19
- 239000008363 phosphate buffer Substances 0.000 description 18
- 210000000214 mouth Anatomy 0.000 description 16
- 230000007935 neutral effect Effects 0.000 description 16
- 210000003238 esophagus Anatomy 0.000 description 14
- 239000000758 substrate Substances 0.000 description 14
- 240000008042 Zea mays Species 0.000 description 13
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 13
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 13
- 235000005822 corn Nutrition 0.000 description 13
- 230000002255 enzymatic effect Effects 0.000 description 13
- 235000014590 basal diet Nutrition 0.000 description 12
- 235000013330 chicken meat Nutrition 0.000 description 12
- 238000011534 incubation Methods 0.000 description 11
- 206010012735 Diarrhoea Diseases 0.000 description 9
- 239000000654 additive Substances 0.000 description 9
- 230000000996 additive effect Effects 0.000 description 9
- 235000013312 flour Nutrition 0.000 description 9
- 238000013459 approach Methods 0.000 description 8
- 239000008367 deionised water Substances 0.000 description 8
- 229910021641 deionized water Inorganic materials 0.000 description 8
- 230000002478 diastatic effect Effects 0.000 description 8
- 230000004060 metabolic process Effects 0.000 description 8
- 239000013589 supplement Substances 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 235000019784 crude fat Nutrition 0.000 description 7
- 210000003608 fece Anatomy 0.000 description 7
- 230000000977 initiatory effect Effects 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 235000019750 Crude protein Nutrition 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 238000013461 design Methods 0.000 description 6
- 230000003203 everyday effect Effects 0.000 description 6
- 230000001228 trophic effect Effects 0.000 description 6
- 230000003698 anagen phase Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000002689 soil Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 210000002700 urine Anatomy 0.000 description 5
- 244000063299 Bacillus subtilis Species 0.000 description 4
- 239000007853 buffer solution Substances 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 230000002503 metabolic effect Effects 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000011550 stock solution Substances 0.000 description 4
- 230000001502 supplementing effect Effects 0.000 description 4
- 241000193744 Bacillus amyloliquefaciens Species 0.000 description 3
- 239000001856 Ethyl cellulose Substances 0.000 description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 102000057297 Pepsin A Human genes 0.000 description 3
- 108090000284 Pepsin A Proteins 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 230000001458 anti-acid effect Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000007405 data analysis Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000002702 enteric coating Substances 0.000 description 3
- 238000009505 enteric coating Methods 0.000 description 3
- 239000012259 ether extract Substances 0.000 description 3
- 229920001249 ethyl cellulose Polymers 0.000 description 3
- 235000019325 ethyl cellulose Nutrition 0.000 description 3
- 238000013401 experimental design Methods 0.000 description 3
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 3
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 3
- 229940111202 pepsin Drugs 0.000 description 3
- 244000144977 poultry Species 0.000 description 3
- 235000013594 poultry meat Nutrition 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 235000019419 proteases Nutrition 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- DEWLEGDTCGBNGU-UHFFFAOYSA-N 1,3-dichloropropan-2-ol Chemical compound ClCC(O)CCl DEWLEGDTCGBNGU-UHFFFAOYSA-N 0.000 description 2
- 101710130006 Beta-glucanase Proteins 0.000 description 2
- 108010059892 Cellulase Proteins 0.000 description 2
- 239000004971 Cross linker Substances 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 2
- 229920001503 Glucan Polymers 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 241001499740 Plantago alpina Species 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 229920013820 alkyl cellulose Polymers 0.000 description 2
- 238000000540 analysis of variance Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- JSAIENUMNDAGTD-UHFFFAOYSA-N benzene ethene styrene Chemical compound C1=CC=CC=C1.C=C.C=C.C=CC1=CC=CC=C1 JSAIENUMNDAGTD-UHFFFAOYSA-N 0.000 description 2
- 230000001588 bifunctional effect Effects 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 229940106157 cellulase Drugs 0.000 description 2
- 238000013270 controlled release Methods 0.000 description 2
- 229920006037 cross link polymer Polymers 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 210000003746 feather Anatomy 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000003306 harvesting Methods 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002417 nutraceutical Substances 0.000 description 2
- 235000021436 nutraceutical agent Nutrition 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 1
- 101710146708 Acid alpha-amylase Proteins 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241001260012 Bursa Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 235000019743 Choline chloride Nutrition 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 244000046109 Sorghum vulgare var. nervosum Species 0.000 description 1
- 101000693530 Staphylococcus aureus Staphylokinase Proteins 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 150000007824 aliphatic compounds Chemical class 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 244000144987 brood Species 0.000 description 1
- 239000012928 buffer substance Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229920006184 cellulose methylcellulose Polymers 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 description 1
- 229960003178 choline chloride Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013400 design of experiment Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 230000025507 digestive system development Effects 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical group CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 239000004459 forage Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000010226 intestinal metabolism Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- NXMXPVQZFYYPGD-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;methyl prop-2-enoate Chemical compound COC(=O)C=C.COC(=O)C(C)=C NXMXPVQZFYYPGD-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- IQSHMXAZFHORGY-UHFFFAOYSA-N methyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound COC(=O)C=C.CC(=C)C(O)=O IQSHMXAZFHORGY-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- GBCAVSYHPPARHX-UHFFFAOYSA-M n'-cyclohexyl-n-[2-(4-methylmorpholin-4-ium-4-yl)ethyl]methanediimine;4-methylbenzenesulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.C1CCCCC1N=C=NCC[N+]1(C)CCOCC1 GBCAVSYHPPARHX-UHFFFAOYSA-M 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-N o-dicarboxybenzene Natural products OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960005137 succinic acid Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Fodder In General (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29544410P | 2010-01-15 | 2010-01-15 | |
| US61/295,444 | 2010-01-15 | ||
| CN2011800096418A CN103118547A (zh) | 2010-01-15 | 2011-01-17 | 受保护的α-淀粉酶 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011800096418A Division CN103118547A (zh) | 2010-01-15 | 2011-01-17 | 受保护的α-淀粉酶 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105394354A true CN105394354A (zh) | 2016-03-16 |
Family
ID=44309146
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510537496.0A Pending CN105394354A (zh) | 2010-01-15 | 2011-01-17 | 受保护的α-淀粉酶 |
| CN2011800096418A Pending CN103118547A (zh) | 2010-01-15 | 2011-01-17 | 受保护的α-淀粉酶 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011800096418A Pending CN103118547A (zh) | 2010-01-15 | 2011-01-17 | 受保护的α-淀粉酶 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110183032A1 (https=) |
| EP (1) | EP2557938B1 (https=) |
| CN (2) | CN105394354A (https=) |
| BR (1) | BR112012017453A2 (https=) |
| ES (1) | ES2836811T3 (https=) |
| IN (1) | IN2012DN06642A (https=) |
| WO (1) | WO2012169997A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8778442B2 (en) * | 2011-06-30 | 2014-07-15 | The Quaker Oats Company | Method for preparing extruded legume micro pellets |
| AU2014356406B2 (en) * | 2013-11-29 | 2018-06-14 | Novonesis Animal Biosolutions Ag | Use of bacterial amylases in feed for poultry |
| MX2021003930A (es) * | 2018-10-05 | 2021-06-04 | Basf Se | Compuestos estabilizadores de hidrolasas en liquidos. |
| CN112805377A (zh) * | 2018-10-05 | 2021-05-14 | 巴斯夫欧洲公司 | 在液体中稳定淀粉酶的化合物 |
| CN109527224A (zh) * | 2018-12-30 | 2019-03-29 | 珠海天凯生物科技有限公司 | 一种饲用复合酶制剂 |
| CN110292118A (zh) * | 2019-07-26 | 2019-10-01 | 兰州百源基因技术有限公司 | 一种饲料组合物及其制备和应用 |
| GB201919441D0 (en) * | 2019-12-31 | 2020-02-12 | Devenish Res Development And Innovation Limited | A dietary composition comprising an ingredient of interest |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1235824A (zh) * | 1998-02-26 | 1999-11-24 | 一洋药品株式会社 | 包肠溶衣的胰酶颗粒的制备方法 |
| US20010001668A1 (en) * | 1996-11-23 | 2001-05-24 | Karsten Cremer | Lozenge for the modified releasing of active substances in the gastrointestinal tract |
| CN1665490A (zh) * | 2002-07-05 | 2005-09-07 | 特姆雷尔公司 | 控释组合物 |
| CN1817173A (zh) * | 2005-12-28 | 2006-08-16 | 湖南尤特尔生化有限公司 | 一种饲用肠溶微丸酶的生产方法 |
| CN1943783A (zh) * | 2006-09-27 | 2007-04-11 | 常州千红生化制药有限公司 | 复方消化酶制剂及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2560830A (en) * | 1945-10-22 | 1951-07-17 | American Dairies Inc | Feed for ruminant animals |
| CH283585A (de) * | 1950-03-15 | 1952-06-15 | Hoffmann La Roche | Zur Herstellung von Tablettenüberzügen geeignetes Gemisch. |
| KR940000065B1 (ko) * | 1986-08-28 | 1994-01-05 | 코 사이 잉 토마스 | 동물 성장 촉진제 |
| FR2606597B1 (fr) * | 1986-11-17 | 1989-01-27 | Rhone Poulenc Sante | Nouvelle composition pour l'alimentation des ruminants contenant une substance biologiquement active et sa preparation |
| JPS63258809A (ja) * | 1987-04-16 | 1988-10-26 | Towa Yakuhin Kk | 医薬活性成分の放出性にすぐれ、かつ苦味を隠蔽した細粒剤 |
| AU8317487A (en) | 1987-04-17 | 1988-10-20 | Ecolab Inc. | Water insoluble encapsulated enzymes protected against deactivation by halogen bleaches |
| US5314692A (en) * | 1987-08-24 | 1994-05-24 | Cultor Ltd. | Enzyme premix for feed and method |
| US6306427B1 (en) * | 1989-12-28 | 2001-10-23 | Rhone-Poulenc Nutrition Animale | Pellets containing active ingredients protected against degradation in the rumen of ruminants |
| US5750104A (en) * | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
| BRPI0408158A8 (pt) * | 2003-03-06 | 2017-12-05 | Diversa Corp | Amilases, ácidos nucléicos codificando-as e métodos para preparar e empregá-las |
| AU2005249422B2 (en) * | 2004-05-27 | 2011-03-17 | Genencor International, Inc. | Acid-stable alpha amylases having granular starch hydrolyzing activity and enzyme compositions |
| KR100804096B1 (ko) * | 2006-08-31 | 2008-02-18 | (주)아모레퍼시픽 | 고농도 계면활성제 계에서도 안정한 효소 캡슐 제제를포함하는 피부 세정용 조성물 및 그 제조방법 |
-
2011
- 2011-01-17 WO PCT/US2011/021474 patent/WO2012169997A1/en not_active Ceased
- 2011-01-17 IN IN6642DEN2012 patent/IN2012DN06642A/en unknown
- 2011-01-17 BR BRBR112012017453-3A patent/BR112012017453A2/pt not_active Application Discontinuation
- 2011-01-17 EP EP11856630.6A patent/EP2557938B1/en active Active
- 2011-01-17 CN CN201510537496.0A patent/CN105394354A/zh active Pending
- 2011-01-17 CN CN2011800096418A patent/CN103118547A/zh active Pending
- 2011-01-17 ES ES11856630T patent/ES2836811T3/es active Active
- 2011-01-17 US US13/007,866 patent/US20110183032A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010001668A1 (en) * | 1996-11-23 | 2001-05-24 | Karsten Cremer | Lozenge for the modified releasing of active substances in the gastrointestinal tract |
| CN1235824A (zh) * | 1998-02-26 | 1999-11-24 | 一洋药品株式会社 | 包肠溶衣的胰酶颗粒的制备方法 |
| CN1665490A (zh) * | 2002-07-05 | 2005-09-07 | 特姆雷尔公司 | 控释组合物 |
| CN1817173A (zh) * | 2005-12-28 | 2006-08-16 | 湖南尤特尔生化有限公司 | 一种饲用肠溶微丸酶的生产方法 |
| CN1943783A (zh) * | 2006-09-27 | 2007-04-11 | 常州千红生化制药有限公司 | 复方消化酶制剂及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 温辉梁: "《饲料添加剂生产技术与配方》", 31 December 2009, 江西科学技术出版社 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2557938B1 (en) | 2020-10-14 |
| US20110183032A1 (en) | 2011-07-28 |
| WO2012169997A1 (en) | 2012-12-13 |
| EP2557938A1 (en) | 2013-02-20 |
| EP2557938A4 (en) | 2013-11-20 |
| BR112012017453A2 (pt) | 2015-09-01 |
| IN2012DN06642A (https=) | 2015-10-23 |
| CN103118547A (zh) | 2013-05-22 |
| ES2836811T3 (es) | 2021-06-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Abdollahi et al. | Influence of palm kernel meal inclusion and exogenous enzyme supplementation on growth performance, energy utilization, and nutrient digestibility in young broilers | |
| Choct et al. | A comparison of three xylanases on the nutritive value of two wheats for broiler chickens | |
| CN105394354A (zh) | 受保护的α-淀粉酶 | |
| JP2014508519A (ja) | 飼料添加用組成物 | |
| JP2015528705A (ja) | 飼料添加用組成物 | |
| Rodriguez et al. | Exogenous enzymes in aquaculture: Alginate and alginate-bentonite microcapsules for the intestinal delivery of shrimp proteases to Nile tilapia | |
| CN113897299A (zh) | 一种复合微生态制剂及其应用 | |
| Wang et al. | Effects of sodium humate and glutamine combined supplementation on growth performance, diarrhea incidence, blood parameters, and intestinal microflora of weaned calves | |
| CN107028021A (zh) | 一种有效解决肉中鸡饲料便的配合饲料及制备方法 | |
| Abdollahi et al. | Influence of partial replacement of ground wheat with whole wheat and exogenous enzyme supplementation on growth performance, nutrient digestibility and energy utilization in young broilers | |
| EP3542639B1 (en) | Ingredient for animal feed, feed and a method for feeding animals | |
| Passos et al. | Individual or combinational use of phytase, protease, and xylanase for the impacts on total tract digestibility of corn, soybean meal, and distillers dried grains with soluble fed to pigs | |
| El-Sagheer et al. | Effect of enzymes and probiotic mixture supplementation to the diet of growing female rabbits on performance and carcass criteria | |
| AU2014339904B2 (en) | Use of ferulic acid esterase to improve performance in monogastric animals | |
| Khan et al. | Effect of enzyme and yeast-based feed additives on growth, nutrient digestibility, meat quality and intestinal morphology of fattening rabbits | |
| Mun et al. | Nutrient density and the collaborative impact of exogenous enzyme blend on the performance of broiler chicken | |
| CN103798522B (zh) | 一种降低动物粪便中氮磷排泄量的饲料添加剂 | |
| Zhang et al. | Bacillus subtilis: applications in the livestock and poultry industry in recent years | |
| Thamaraikannan et al. | Influence of enzyme mixture supplementation on growth performance, nutrient digestibility, and fecal score in growing pigs | |
| Min et al. | Effect of Rovabio® Max AP on performance, energy and nitrogen digestibility of diets high in distillers dried grains with solubles (DDGS) in broilers | |
| Sacakli et al. | Effect of dietary β-mannanase supplementation on growth performance and nutrient retention in broiler chickens fed corn-soybean meal-based diets with low energy and amino acid density | |
| Adeleye et al. | Whole pearl millet feeding does not impair performance and nutrient digestibility in 28‐day‐old broiler chickens | |
| Manwar et al. | Effect of reconstitution of sorghum with or without enzymes on production performance and immunocompetence in broiler chicken | |
| CA2145961A1 (en) | Use of an enzyme for assisting an animal to digest protein | |
| Idan | The role of feed processing and fiber addition on improving the nutrition and growth performance of broilers |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160316 |
|
| RJ01 | Rejection of invention patent application after publication |