CN105388273A - Multifunctional biochip reading instrument - Google Patents
Multifunctional biochip reading instrument Download PDFInfo
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- CN105388273A CN105388273A CN201510828515.5A CN201510828515A CN105388273A CN 105388273 A CN105388273 A CN 105388273A CN 201510828515 A CN201510828515 A CN 201510828515A CN 105388273 A CN105388273 A CN 105388273A
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- biochip
- chip
- claw
- claws
- objective box
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Abstract
The invention discloses a multifunctional biochip reading instrument, comprising a shell, a loading box arranged in the shell and used for loading a biochip, a chip gripper device, a collection device for collecting biochip information, shading devices, a controlling device for controlling the operation of the multifunctional biochip reading instrument, and a chip cleaning device, wherein the biochip loading box is provided with the biochip with multiple loci, two sides of the loading box are provided with limiting strips, and the rear side of the loading box is provided with a limiting block; the shading devices are mounted at two sides of the loading box, the collection device is erected on the shading devices, and comprises a CCD camera, an objective lens connected to a photosensitive port of the CCD camera, and a camera power supply connected with the CCD camera, and the objective lens directly faces the loading box. The multifunctional biochip reading instrument integrates biochip reading and chip cleaning, and has the characteristics of being compact in structure, space-saving and convenient to use.
Description
Technical field
The present invention relates to a kind of multifunctional biochip reading apparatus.
Background technology
Biological chip testing technology, fluorescence, biotin or additive method is adopted to mark biomolecule (as DNA, RNA, protein molecular, antigen, the antibody etc.) target be fixed on bio-chip substrate, and marking signal is changed into the view data that can supply analyzing and processing by building some special pick-up units, to obtain and to analyze the various information such as biology, physics, chemistry of the biomolecule on biochip, the time of day of diagnostic biomolecule.
Biochip test equipment is widely used in the fields such as scientific research, medicine, health, for catching and processing the instrument of biochip image, traditional biochip supplies analysis has the following disadvantages: the handgrip function ratio of (1) chip detection instrument is more single, distance (2) checkout equipment between manual shift handgrip clamping device is needed generally to be divided into multiple chamber by dividing plate when capturing different chips, make the volume of checkout equipment larger, structure is comparatively complicated, dismounting is inconvenient, is not easy to use.(3) biochip needs are fixed after aliging with object lens again, and manual shift position is inaccurate.(4) in detecting, due to higher to the requirement for horizontality of biochip, then biochip slightly offset level position time, the easily accuracy of impact observation image.(5) there is not chip cleaning function in checkout equipment.
Summary of the invention
The invention provides a kind of multifunctional biochip reading apparatus, its object is to solve conventional bio-chip assay device structures complicated, volume is comparatively large, uses the problems such as comparatively inconvenience.
A kind of multifunctional biochip reading apparatus, comprise housing, be located in housing for carry biochip objective box, for chip gripper equipment, for gather biochip information harvester and shade, for controlling control device, the device for cleaning chip of the running of a kind of multifunctional biochip reading apparatus, it is characterized in that: the objective box of described biochip arranges the biochip with multiple site; Described chip gripper equipment comprises motor mount, body frame, direct current generator, motor lead screw, activity are won in succession, bindiny mechanism, movable clamping device and pick-and-place device; Described pick-and-place device, comprise framework, be located at two claws on described framework and adjust wide assembly, described two claws are oppositely arranged, the wide assembly of described tune is connected the distance between adjustment two claws with described claw, described shade is for being installed on this objective box both sides, described harvester comprises CCD camera, is connected to the object lens of the photosensitive port of this CCD camera, and described object lens are right against objective box; Device for cleaning chip is made up of main body, chip accommodation box and sliding panel, described main body is for comprising bilevel structure, and upper and lower two-layer interval is arranged, described chip accommodation box is connected on sliding panel, described sliding panel drives chip accommodation box slide anteroposterior, described sliding panel run through main body two-layer up and down between; The fluorescence that each site of described objective box produces is all through the object lens of the photosensitive port corresponding to each site, and these objective box both sides are provided with positive stop strip, are provided with limited block on rear side of objective box; Described body frame is arranged on the side of motor mount, described direct current generator is arranged in motor mount, described activity clamping organization establishes is in body frame, described motor lead screw is won in succession with activity and is connected, described activity is won in succession and to be flexibly connected by bindiny mechanism with movable clamping device, and the opposite side of described motor mount is provided with optically-coupled catch and photoelectric sensor; Have the guide pole that the direction along claw adjustment distance is arranged in described framework, described guide pole is arranged on two claws, and the quantity of described guide pole is two, and two guide poles are arranged in parallel, and described guide pole is connected by linear bearing with between claw; The wide assembly of described tune comprises motor, driving-belt and power wheel, described driving-belt and motor, power wheel are connected to form two parallel and traction belts that direction of motion is contrary, described two traction belts are fixedly connected with two claws respectively and the tune cross direction of direction of motion and claw is consistent, and described motor positive and inverse drives driving-belt to drive two claws relatively or deviate from motion; Be provided with chip induction installation between described two claws, described chip induction installation be located to by corresponding position, the chip two ends picked up; Also comprise the position induction device be located on framework, described position induction device at least comprises the opposing motion of restriction claw and goes beyond the limit of the limit sensors dorsad of position and limit the limit sensors in opposite directions that claw move toward one another goes beyond the limit of position, also comprise the origin position sensor of instruction claw initial position, described origin position sensor at limit sensors dorsad or in opposite directions between limit sensors, and near wherein any one limit sensors; Described control device is connected with a power interface and a power switch, and described control device is provided with a communication interface; Described housing forms by lower house with upper shell, and described objective box is located at the side in housing, the side body be connected offers a test card insert port with this objective box; Described main body is connected with handle, and described main body is provided with two registration pins, and described sliding panel is arranged between two registration pins.
Accompanying drawing explanation
Structural representation when Fig. 1 is chip handgrip grab chips of the present invention.
Fig. 2 is the pick-and-place device schematic diagram of chip handgrip of the present invention.
Fig. 3 is that inner structure of the present invention overlooks direction schematic diagram.
Fig. 4 is device for cleaning chip schematic diagram of the present invention.
In Fig. 1,21-motor mount, 22-direct current generator, 14-motor lead screw, 25 for activity win in succession, 26 be bindiny mechanism, 17 be optically-coupled catch, 18 be photoelectric sensor, 19,20 be movable clamping device, 28,29 be pick-and-place device, 27 be retaining collar, 23 for body frame.
In Fig. 2,202-pallet connecting portion, 204-framework, 205-left jamming claw, 206-right jamming claw, 208-adjust wide assembly, 210-guide pole, 212-linear bearing, 214-chip induction installation, 282-stepper motor, 284-power wheel, 285-driving-belt, 286-traction belt, 252-breach, 216-limit sensors, 220-origin position sensor.
In Fig. 3,10-housing, 12-objective box, 120-positive stop strip, 121-limited block, 13-shade, 15-control device, 150-power interface, 151-power switch, 16-harvester, 160-communication interface, 111-device for cleaning chip, 222-chip gripper equipment.
In Fig. 4,5-main body, 1-chip accommodation box, 4-sliding panel, 7-handle, 6-register pin.
Embodiment
Below in conjunction with the drawings and specific embodiments, the invention will be further described:
A kind of multifunctional biochip reading apparatus, comprise housing 10, be located in housing 10 for carry biochip objective box 12, for chip gripper equipment 222, for gather biochip information harvester 16 and shade 13, for controlling control device 15, the device for cleaning chip 222 of the running of a kind of multifunctional biochip reading apparatus, it is characterized in that: the objective box 12 of described biochip arranges the biochip with multiple site; Described chip gripper equipment 222 comprises motor mount 21, body frame 23, direct current generator 22, motor lead screw 14, activity are won in succession 25, bindiny mechanism 26, movable clamping device 19,20 and pick-and-place device 28,29; Described pick-and-place device, comprise framework 204, be located at two claws 205,206 on described framework 204 and adjust wide assembly 208, described two claws are oppositely arranged, described tune wide group 208 is connected the distance between adjustment two claws with described claw, described shade 13 is for being installed on this objective box 12 both sides, described harvester 16 comprises CCD camera, is connected to the object lens of the photosensitive port of this CCD camera, and described object lens are right against objective box 12; Device for cleaning chip 111 is made up of main body 5, chip accommodation box 1 and sliding panel 4, described main body 5 is for comprising bilevel structure, and upper and lower two-layer interval is arranged, described chip accommodation box 1 is connected on sliding panel 4, described sliding panel 4 drives chip accommodation box slide anteroposterior, described sliding panel 4 run through main body two-layer up and down between; The fluorescence that described each site of objective box 12 produces is all through the object lens of the photosensitive port corresponding to each site, and these objective box 12 both sides are provided with positive stop strip 120, are provided with limited block 121 on rear side of objective box 12; Described body frame 23 is arranged on the side of motor mount 21, described direct current generator 22 is arranged in motor mount 21, described movable clamping device 19,20 is arranged in body frame 23, described motor lead screw 14 and activity are won in succession and 25 to be connected, described activity is won in succession and 25 to be flexibly connected by bindiny mechanism 26 with movable clamping device 19,20, and the opposite side of described motor mount 21 is provided with optically-coupled catch 17 and photoelectric sensor 18; The guide pole 210 that the direction along claw adjustment distance is arranged is had in described framework 204, described guide pole 210 is arranged on two claws, the quantity of described guide pole 210 is two, and two guide poles are arranged in parallel, and described guide pole is connected by linear bearing 212 with between claw; The wide assembly 208 of described tune comprises motor 282, driving-belt 285 and power wheel 284, described driving-belt 285 and motor 282, power wheel 284 are connected to form two parallel and traction belts 286 that direction of motion is contrary, described two traction belts 286 are fixedly connected with two claws respectively and the tune cross direction of direction of motion and claw is consistent, and described motor positive and inverse drives driving-belt to drive two claws relatively or deviate from motion; Be provided with chip induction installation 214 between described two claws, described chip induction installation 214 be located to by corresponding position, the chip two ends picked up; Also comprise the position induction device be located on framework, described position induction device at least comprises the opposing motion of restriction claw and goes beyond the limit of the limit sensors dorsad of position and limit the limit sensors in opposite directions that claw move toward one another goes beyond the limit of position, also comprise the origin position sensor 220 of instruction claw initial position, described origin position sensor 220 at limit sensors 216 dorsad or in opposite directions between limit sensors 216, and near wherein any one limit sensors 216; Described control device 15 is connected with power interface 150 and a power switch 151, and described control device 15 is provided with a communication interface 160.
Claims (3)
1. a multifunctional biochip reading apparatus, comprise housing, be located in housing for carry biochip objective box, for chip gripper equipment, for gather biochip information harvester and shade, for controlling control device, the device for cleaning chip of the running of a kind of multifunctional biochip reading apparatus, it is characterized in that: the objective box of described biochip arranges the biochip with multiple site; Described chip gripper equipment comprises motor mount, body frame, direct current generator, motor lead screw, activity are won in succession, bindiny mechanism, movable clamping device and pick-and-place device; Described pick-and-place device, comprise framework, be located at two claws on described framework and adjust wide assembly, described two claws are oppositely arranged, the wide assembly of described tune is connected the distance between adjustment two claws with described claw, described shade is for being installed on this objective box both sides, described harvester comprises CCD camera, is connected to the object lens of the photosensitive port of this CCD camera, and described object lens are right against objective box; Device for cleaning chip is made up of main body, chip accommodation box and sliding panel, described main body is for comprising bilevel structure, and upper and lower two-layer interval is arranged, described chip accommodation box is connected on sliding panel, described sliding panel drives chip accommodation box slide anteroposterior, described sliding panel run through main body two-layer up and down between; The fluorescence that each site of described objective box produces is all through the object lens of the photosensitive port corresponding to each site, and these objective box both sides are provided with positive stop strip, are provided with limited block on rear side of objective box; Described body frame is arranged on the side of motor mount, described direct current generator is arranged in motor mount, described activity clamping organization establishes is in body frame, described motor lead screw is won in succession with activity and is connected, described activity is won in succession and to be flexibly connected by bindiny mechanism with movable clamping device, and the opposite side of described motor mount is provided with optically-coupled catch and photoelectric sensor; Have the guide pole that the direction along claw adjustment distance is arranged in described framework, described guide pole is arranged on two claws, and the quantity of described guide pole is two, and two guide poles are arranged in parallel, and described guide pole is connected by linear bearing with between claw; The wide assembly of described tune comprises motor, driving-belt and power wheel, described driving-belt and motor, power wheel are connected to form two parallel and traction belts that direction of motion is contrary, described two traction belts are fixedly connected with two claws respectively and the tune cross direction of direction of motion and claw is consistent, and described motor positive and inverse drives driving-belt to drive two claws relatively or deviate from motion; Be provided with chip induction installation between described two claws, described chip induction installation be located to by corresponding position, the chip two ends picked up; Also comprise the position induction device be located on framework, described position induction device at least comprises the opposing motion of restriction claw and goes beyond the limit of the limit sensors dorsad of position and limit the limit sensors in opposite directions that claw move toward one another goes beyond the limit of position, also comprise the origin position sensor of instruction claw initial position, described origin position sensor at limit sensors dorsad or in opposite directions between limit sensors, and near wherein any one limit sensors; Described control device is connected with a power interface and a power switch, and described control device is provided with a communication interface.
2. a kind of multifunctional biochip reading apparatus according to claim 1, it is characterized in that: described housing forms by lower house with upper shell, described objective box is located at the side in housing, the side body be connected offers a test card insert port with this objective box.
3. a kind of multifunctional biochip reading apparatus according to claim 1, is characterized in that, described main body is connected with handle, and described main body is provided with two registration pins, and described sliding panel is arranged between two registration pins.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510828515.5A CN105388273A (en) | 2015-11-25 | 2015-11-25 | Multifunctional biochip reading instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510828515.5A CN105388273A (en) | 2015-11-25 | 2015-11-25 | Multifunctional biochip reading instrument |
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| CN105388273A true CN105388273A (en) | 2016-03-09 |
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| CN201510828515.5A Pending CN105388273A (en) | 2015-11-25 | 2015-11-25 | Multifunctional biochip reading instrument |
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| CN104655863A (en) * | 2015-02-10 | 2015-05-27 | 中国科学院苏州生物医学工程技术研究所 | Sample conveying detection system |
| CN105021834A (en) * | 2015-07-19 | 2015-11-04 | 武汉明德生物科技股份有限公司 | Detection card moving mechanism for full-automatic immunity quantitative analyzer |
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2015
- 2015-11-25 CN CN201510828515.5A patent/CN105388273A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003014400A1 (en) * | 2001-08-08 | 2003-02-20 | Applied Precision, Llc | Time-delay integration imaging of biological specimens |
| EP1643556A2 (en) * | 2006-01-16 | 2006-04-05 | Elec Vision Inc. | Contact image capturing structure |
| WO2008149169A1 (en) * | 2007-06-08 | 2008-12-11 | 3Dhistech Kft. | System for handling slides |
| WO2012034094A2 (en) * | 2010-09-09 | 2012-03-15 | The Regents Of The University Of California | Integrated microfluidic radioassay and imaging platform for small sample analysis |
| CN203385718U (en) * | 2013-08-14 | 2014-01-08 | 佰奥达生物科技武汉有限公司 | Detection mechanism of immunity detector |
| CN203612719U (en) * | 2013-12-26 | 2014-05-28 | 杭州中翰盛泰生物技术有限公司 | Full-automatic detection card transporting device for instantaneous check meter |
| CN204241377U (en) * | 2014-07-11 | 2015-04-01 | 广州蓝勃生物科技有限公司 | Light path portable solid phase fluoroscopic examination structure |
| CN104155437A (en) * | 2014-08-27 | 2014-11-19 | 珠海科域生物工程有限公司 | Automatic card adding and conveying device of colloidal gold test paper card |
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Application publication date: 20160309 |