CN105381371A - Traditional Chinese medicine for treating phlegmatic hygrosis obstructing postpartum hypogalactia and preparing method thereof - Google Patents
Traditional Chinese medicine for treating phlegmatic hygrosis obstructing postpartum hypogalactia and preparing method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating phlegmatic hygrosis obstructing postpartum hypogalactia and a preparing method thereof. Respective raw materials of medicinal materials of the traditional Chinese medicine comprise: alpinia katsumadai, rubia membranacea diels, fruit of pungent litse, manglietia insignis, aleuritopteris farinosa, flower of symplocos caudata, betel pepper leaf, root of Tangut Cacalia, Thesium chinense Turcaz, adiantum philippense L., stem and leaf of Shortplume Clematis, vallisneria natans and lysionotus pauciflorus. The traditional Chinese medicine has exact treatment effect for phlegmatic hygrosis obstructing postpartum hypogalactia, and has no toxic and side effects.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of phlegm-damp for the treatment of and stopping up Chinese medicine of resistance type puerperal hypogalactia and preparation method thereof.
Background technology
Puerperal hypogalactia refers to that puerpera is very few in the newborn amount of endocrine in 2 ~ 15 days puerperal, or when within puerperal, age of sucking, milk is just gone, galactopoiesis reduces, inadequate feeding infant, is referred to as hypogalactia, also known as " galactozemia ".The spirit of galactopoiesis and wet nurse, emotion, nutriture, rest and work have relation.Hypogalactia may be poor by development of breast, and the too much or emotion of postpartum hemorrhage is not good enough etc., and factor causes, and infection, diarrhoea, loose stool etc. also can make hypogalactia, or because of milk can not caused by smoothness.And western medicine and medical practitioners there is no the specific drug for the treatment of puerperal hypogalactia.
Milk derives from internal organs, vim and vigour, punching are appointed." tire produces heart method " cloud: " puerpera's punching appoints blood prosperous, taste gas prosperous then breast foot ".Xue Li vegetarian cloud " blood person, the clearing heat in QI system of water paddy also, and adjusts the five internal organs, and the old six internal organs of wine, then turn to essence man, married woman are milk, and lower is the sea of blood ".Illustrate that milk is whether sufficient and have substantial connection with taste vim and vigour are strong, milk is given birth to by QI and blood, relies irritability catharsis and adjustment, therefore hypogalactia is many because of caused by deficient qi and blood, stagnation of QI due to depression of the liver, also has and stagnantly causes galactozemia person because mental disorder is stopped up.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of therapeutic effect good and Chinese medicine of the treatment phlegm-damp had no side effect heap soil or fertilizer over and around the roots resistance type puerperal hypogalactia and preparation method thereof.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of phlegm-damp heap soil or fertilizer over and around the roots resistance type puerperal hypogalactia, its raw medicinal material comprises: Semen Alpiniae Katsumadai, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), Fructus Litseae pungentis, Fructus Manglietiae insignis, water wolf beanstalk, Flos Symplocoris Caudatae ， Folium piperis betlis, Radix Cacaliae Tanguticae, Radix Thesii, black nylon yarn, Caulis et Folium Clematidis Breviscudatae, Herba vallisneriae Spiralis and Herba Lysionoti Pauciflori.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Semen Alpiniae Katsumadai 5 ~ 15 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 15 parts, Fructus Litseae pungentis 10 ~ 20 parts, Fructus Manglietiae insignis 5 ~ 15 parts, water wolf beanstalk 35 ~ 45 parts, Flos Symplocoris Caudatae 10 ~ 20 Fen ， Folium piperis betlis 15 ~ 25 parts, Radix Cacaliae Tanguticae 15 ~ 25 parts, Radix Thesii 35 ~ 45 parts, black nylon yarn 15 ~ 25 parts, Caulis et Folium Clematidis Breviscudatae 5 ~ 15 parts, Herba vallisneriae Spiralis 10 ~ 20 parts and Herba Lysionoti Pauciflori 10 ~ 20 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Semen Alpiniae Katsumadai 5 ~ 10 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 10 parts, Fructus Litseae pungentis 10 ~ 15 parts, Fructus Manglietiae insignis 5 ~ 10 parts, water wolf beanstalk 35 ~ 40 parts, Flos Symplocoris Caudatae 10 ~ 15 Fen ， Folium piperis betlis 15 ~ 20 parts, Radix Cacaliae Tanguticae 15 ~ 20 parts, Radix Thesii 35 ~ 40 parts, black nylon yarn 15 ~ 20 parts, Caulis et Folium Clematidis Breviscudatae 5 ~ 10 parts, Herba vallisneriae Spiralis 10 ~ 15 parts and Herba Lysionoti Pauciflori 10 ~ 15 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Semen Alpiniae Katsumadai 6 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 8 parts, Fructus Litseae pungentis 12 parts, Fructus Manglietiae insignis 7 parts, water wolf beanstalk 38 parts, Flos Symplocoris Caudatae 14 Fen ， Folium piperis betlis 16 parts, Radix Cacaliae Tanguticae 19 parts, Radix Thesii 36 parts, black nylon yarn 17 parts, Caulis et Folium Clematidis Breviscudatae 8 parts, Herba vallisneriae Spiralis 11 parts and Herba Lysionoti Pauciflori 14 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine component is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 80 ~ 90%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.5 times, the lactose of 0.05 ~ 0.1 times, the starch of 0.1 ~ 0.5 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85 ~ 95%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 200 order ~ 300 object micropowders;
3rd step: add the starch relative to its quality 3 ~ 5 times in the micropowders obtained by second step, mixing, obtains powder.
Beneficial effect of the present invention: Chinese medicine of the present invention stops up resistance type puerperal hypogalactia to phlegm-damp definite curative effect, has no side effect.
Detailed description of the invention
The invention provides a kind of Chinese medicine for the treatment of phlegm-damp heap soil or fertilizer over and around the roots resistance type puerperal hypogalactia, its raw medicinal material comprises: Semen Alpiniae Katsumadai, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), Fructus Litseae pungentis, Fructus Manglietiae insignis, water wolf beanstalk, Flos Symplocoris Caudatae ， Folium piperis betlis, Radix Cacaliae Tanguticae, Radix Thesii, black nylon yarn, Caulis et Folium Clematidis Breviscudatae, Herba vallisneriae Spiralis and Herba Lysionoti Pauciflori.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Semen Alpiniae Katsumadai: the seed group that [source] is zingiberaceous plant Semen Alpiniae Katsumadai.[nature and flavor] acrid in the mouth; Warm in nature.[return through] returns spleen, stomach warp.[function cures mainly] warming middle-JIAO dampness, circulation of qi promoting spleen invigorating.The coldness and pain in the epigastrium of the cloudy stagnant taste of main cold-damp, feeling of fullness is done swollen, and vomiting, has loose bowels, and food indigested food, expectorant Yu, beriberi, explains malaria, halitosis.
Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis): [source] is polygonaceae plant Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), the herb of undercoat Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis).[nature and flavor] are pungent, bitter, cool in nature.[function cures mainly] cooling blood for hemostasis, clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.Main hemoptysis, spit blood, have blood in stool, metrorrhagia, has loose bowels, dysentery, stomachache, abdominal pain in menstruation, puerperal abdominal pain due to blood stasis, traumatic injury, rheumatic arthralgia, scrofula, carbuncle.
Fructus Litseae pungentis: [source] is the fruit of canella Litsea euosma, Litsea mollifolia and Fructus Litseae pungentis.[nature and flavor] are pungent; Bitter; Warm in nature.[return through] returns spleen, stomach warp.The pain relieving of [function cures mainly] warming middle-JIAO to promote flow of QI, drying damp and strengthening spleenly helps digestion, removing toxic substances and promoting subsidence of swelling.Main cold syndrome of the stomach stomachache, heat-damp in summer is vomited and diarrhoea, and dyspepsia is glutted, dysmenorrhea, colic, malaria, and skin infection swells and ache.
Fructus Manglietiae insignis: [source] is the bark of Magnoliacea plant Fructus Manglietiae insignis.[nature and flavor] are bitter, pungent, warm in nature.[function cures mainly] is drying damp and strengthening spleen.Main gastral cavity abdomen feeling of fullness distending pain, indigestion, vomiting, has loose bowels, dysentery.
Water wolf beanstalk: [source] fern Sinopteridaceae Aleuritopteris farinsa (Forsk.) Fee platymiscium Aleuritopteris farinsa (Forsk.) Fee, with all herbal medicine.[nature and flavor] are bitter, micro-puckery, temperature.[function cures mainly] relieving cough and resolving phlegm, the spleen strengthening and damp drying, blood circulation promoting and blood stasis dispelling.For acute and chronic bronchitis, pertussis, dyspepsia, dysentery, stomachache, leucorrhea, traumatic injury.
Flos Symplocoris Caudatae: [source] is the flower of Symplocaceae plant mountain vitriol.[nature and flavor] are bitter, pungent, and property is put down.[return through] returns lung meridian.[function cures mainly] eliminating phlegm and relaxing heart, promoting the production of body fluid to quench thirst.Main cough is uncomfortable in chest, and children's quenches one's thirst.
Folium piperis betlis: [source] is the leaf of Piperaceae Zhi Wu Spica piperis betlis.[nature and flavor] are pungent, temperature.[return through] returns lung, stomach warp.[function cures mainly] expelling wind and cold, promoting the circulation of QI and reducing phlegm, removing toxic substances and promoting subsidence of swelling, dampness removing to stop itchin.Main cough due to wind and cold, asthma, pertussis, abdominal distention, dyspepsia is indigestion and loss of appetite, edema, and traumatic injury wound is swollen, and rheumatic ostalgia, sore swollen toxin, swelling and pain of hemorrhoid, burn, pathogenic wind-toxic beriberi, mange, eczema epidemic disease is itched.
Radix Cacaliae Tanguticae: [source] is the rhizome of feverfew Cacalia tangutica.[nature and flavor] acrid in the mouth, micro-hardship, property is put down.[function cures mainly] dispels the wind, suppressing the hyperactive liver, pleasantly reduces phlegm.Main rheumatalgia, has a headache dizzy, partially completes, full side of body distension, cough with copious phlegm.
Radix Thesii: [source] is the root of Santalaceae plant Herba Thesii.[nature and flavor] micro-hardship, pungent, property is put down.[function cures mainly] promoting flow of QI and blood, lactogenesis.Main menoxenia, agalactia.
Black nylon yarn: [source] is the herb of adiantaceae plant semilune venushair fern.[nature and flavor] are light, flat.[return through] returns lung, urinary bladder channel.[function cures mainly] clearing away lung-heat to relieve cough, relieving stranguria by diuresis, eliminating carbuncle stimulating milk secretion.Main cough due to lung-heat, urine leaching pain, acute mastitis swells and ache, agalactia.
Caulis et Folium Clematidis Breviscudatae: the rattan that [source] is ranunculaceae plant shortplucme clematis or root.[nature and flavor] bitter in the mouth, cool in nature.[return through] returns liver, urinary bladder channel.[function cures mainly] clearing away heat and promoting diuresis, wind-damp dispelling, stimulating milk secretion of stimulating the menstrual flow.Main damp-heat gonorrhoea, rheumatic arthralgia, puerpera's galactostasis.
Herba vallisneriae Spiralis: [source] is the herb of Hydrocharctaceae plant Herba vallisneriae Spiralis.[nature and flavor] bitter in the mouth, warm in nature.[return through] returns spleen, Liver Channel.[function cures mainly] dampness leukorrhagia stopping, promoting flow of QI and blood.Under master tape, color is white, prolonged lochia.
Herba Lysionoti Pauciflori: [source] is the herb of Gesneriaceae Lysionotus phytobezoar bracketplant.[nature and flavor] bitter in the mouth is cool.[function cures mainly] clearing away heat-damp and promoting diuresis, expelling phlegm for arresting cough, promoting blood flow to regulate menstruation.For cough, bronchitis, dysentery, leptospirosis, rheumatalgia, traumatic injury, menoxenia, leucorrhea.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Semen Alpiniae Katsumadai 5 ~ 15 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 15 parts, Fructus Litseae pungentis 10 ~ 20 parts, Fructus Manglietiae insignis 5 ~ 15 parts, water wolf beanstalk 35 ~ 45 parts, Flos Symplocoris Caudatae 10 ~ 20 Fen ， Folium piperis betlis 15 ~ 25 parts, Radix Cacaliae Tanguticae 15 ~ 25 parts, Radix Thesii 35 ~ 45 parts, black nylon yarn 15 ~ 25 parts, Caulis et Folium Clematidis Breviscudatae 5 ~ 15 parts, Herba vallisneriae Spiralis 10 ~ 20 parts and Herba Lysionoti Pauciflori 10 ~ 20 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Semen Alpiniae Katsumadai 5 ~ 10 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 10 parts, Fructus Litseae pungentis 10 ~ 15 parts, Fructus Manglietiae insignis 5 ~ 10 parts, water wolf beanstalk 35 ~ 40 parts, Flos Symplocoris Caudatae 10 ~ 15 Fen ， Folium piperis betlis 15 ~ 20 parts, Radix Cacaliae Tanguticae 15 ~ 20 parts, Radix Thesii 35 ~ 40 parts, black nylon yarn 15 ~ 20 parts, Caulis et Folium Clematidis Breviscudatae 5 ~ 10 parts, Herba vallisneriae Spiralis 10 ~ 15 parts and Herba Lysionoti Pauciflori 10 ~ 15 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Semen Alpiniae Katsumadai 6 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 8 parts, Fructus Litseae pungentis 12 parts, Fructus Manglietiae insignis 7 parts, water wolf beanstalk 38 parts, Flos Symplocoris Caudatae 14 Fen ， Folium piperis betlis 16 parts, Radix Cacaliae Tanguticae 19 parts, Radix Thesii 36 parts, black nylon yarn 17 parts, Caulis et Folium Clematidis Breviscudatae 8 parts, Herba vallisneriae Spiralis 11 parts and Herba Lysionoti Pauciflori 14 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine component is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 80 ~ 90%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.5 times, the lactose of 0.05 ~ 0.1 times, the starch of 0.1 ~ 0.5 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85 ~ 95%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 200 order ~ 300 object micropowders;
3rd step: add the starch relative to its quality 3 ~ 5 times in the micropowders obtained by second step, mixing, obtains powder.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: tablet
Get Semen Alpiniae Katsumadai 60g, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 80g, Fructus Litseae pungentis 120g, Fructus Manglietiae insignis 70g, water wolf beanstalk 380g, Flos Symplocoris Caudatae 140g ， Folium piperis betlis 160g, Radix Cacaliae Tanguticae 190g, Radix Thesii 360g, black nylon yarn 170g, Caulis et Folium Clematidis Breviscudatae 80g, Herba vallisneriae Spiralis 110g and Herba Lysionoti Pauciflori 140g;
Prepare according to the following steps:
The first step: each for described Chinese medicine component is mixed in proportion, adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 90%, reflux 2 hours, extract, filter acquisition first extracting solution, it is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 3 times again, reflux 1 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 hours, pulverize and sieve acquisition 200 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.3 times, the lactose of 0.1 times, the starch of 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, dry, add the magnesium stearate relative to micropowders quality 0.01 times, granulate, tabletting, makes.
Embodiment 2: powder
Get Semen Alpiniae Katsumadai 90g, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 50g, Fructus Litseae pungentis 140g, Fructus Manglietiae insignis 60g, water wolf beanstalk 360g, Flos Symplocoris Caudatae 120g ， Folium piperis betlis 180g, Radix Cacaliae Tanguticae 170g, Radix Thesii 400g, black nylon yarn 190g, Caulis et Folium Clematidis Breviscudatae 60g, Herba vallisneriae Spiralis 130g and Herba Lysionoti Pauciflori 120g;
Prepare according to the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 85%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 200 object micropowders;
3rd step: add the starch relative to its quality 3 times in the micropowders obtained by second step, mixing, obtains powder.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 24-38g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 8.34g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 41.7 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>41.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 83.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.143g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 31g) oral administration gavage Chinese medicine of the present invention is 583 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention to three groups of mices (often organize 20) by 13.55,22.85 and 42.23g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 84 routine cases are in October, 2013 ~ 2014 my institute in year August and give birth in hospital puerpera.Patient is divided into treatment group and matched group at random, wherein, treatment group 44 people, 20 ~ 38 years old age, average (27.8 ± 2.6) year, week in pregnant week (38.1 ± 2.2), natural labor 11 people, Cesarean esction 33 people; Matched group 40 people, 21 ~ 37 years old age, average (27.5 ± 2.3) year, week in pregnant week (38.2 ± 1.8), natural labor 10 people, Cesarean esction 30 people.Two groups in age, the course of disease, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).
Diagnostic criteria:
Western medicine diagnose standard: the puerperal hypogalactia diagnostic criteria of formulating by " Chinese medical disease Standardization of diagnosis and curative effect ": the milk amount that (1) puerperal discharges is few, even completely without, inadequate feeding infant.(2) breast examination is soft, not swollen not bitterly, extruding milk drop and going out, matter is rare; Or breast enlargement, mammary gland in bulk, extruding milk pain difficulty goes out, and matter is thick.(3) the milk heap soil or fertilizer over and around the roots that eliminating causes because of crater nipple and cracked nipple is amassed obstructed, dysilthia.
Syndrome Differentiation of Traditional Chinese Medicine: phlegm-damp stops up resistance type: puerpera's obesity, lack of lactation after delivery, distending pain of the breast does not uncomfortable in chestly relax, and poor appetite, detests greasy savoury, drowsiness asthenia, and dizzy nose heave, enlarged tongue, tongue is greasy in vain, rolling pulse.
Therapeutic Method:
Treatment group: oral Chinese medicine embodiment 1 tablet of the present invention, each 4, every day 3 times.7 days courses for the treatment of.
Matched group: oral lactogenesis granule (Jiu Zhitang) 4g/ bag of enriching blood, 1 bag/time, 2 times/day.Take 7 days continuously.
Curative effect judging standard: draft according to " Chinese medical disease Standardization of diagnosis and curative effect ".Clinical cure: after medication, milk is stimulated the secretion of milk as gush has sensation, after feeding, baby meets, and can quietly fall asleep after feeding 2 ~ 3h.Effective: medication rear udder attachment is full, has galactopoiesis, and after feeding, baby is substantially satisfied, can quietly fall asleep after feeding 1 ~ 2h.Effective: to have galactopoiesis after medication, increase after sucking, feeding has sometimes cries and screams.Invalid: symptom, without change or breast still soft or scleroma, without galactopoiesis, can not meet baby's feeding, usually cry and scream during feeding, quietly can not fall asleep, need artificial feeding after sucking.
Therapeutic outcome: see the following form.
| Group | n | Clinical cure | Effective | Take a turn for the better | Invalid | Effectively total |
| Treatment group | 44 | 27 | 11 | 5 | 1 | 43(97.73％) |
| Matched group | 40 | 12 | 16 | 7 | 5 | 35(87.50％) |
Treatment group compares with matched group, and treatment group curative effect is better than matched group, and two groups of Different therapeutical effects have statistical significance (P<0.05).
Concrete case: Wang, female, 28 years old.Primipara, the bodily form is fat, and hypogalactia phenomenon appears in 3 days puerperal, usually cries and screams during baby's feeding, can not quietly fall asleep after sucking.Disease sees puerpera's obesity, lack of lactation after delivery, distending pain of the breast, does not uncomfortable in chestly relax, and poor appetite, detests greasy savoury, drowsiness asthenia, dizzy nose heave, enlarged tongue, and tongue is greasy in vain, rolling pulse, diagnosis typing is phlegm-damp stops up resistance type puerperal hypogalactia.Take the embodiment of the present invention 1 tablet, every day 3 times, each 4, after taking 5 days, have sensation of stimulating the secretion of milk, after feeding, baby meets, can quiet more than sleep 3h after feeding, and clinical cure, follows up a case by regular visits to and do not recur for 1 month.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. treat the Chinese medicine that phlegm-damp stops up resistance type puerperal hypogalactia, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Semen Alpiniae Katsumadai, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), Fructus Litseae pungentis, Fructus Manglietiae insignis, water wolf beanstalk, Flos Symplocoris Caudatae ， Folium piperis betlis, Radix Cacaliae Tanguticae, Radix Thesii, black nylon yarn, Caulis et Folium Clematidis Breviscudatae, Herba vallisneriae Spiralis and Herba Lysionoti Pauciflori.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Semen Alpiniae Katsumadai 5 ~ 15 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 15 parts, Fructus Litseae pungentis 10 ~ 20 parts, Fructus Manglietiae insignis 5 ~ 15 parts, water wolf beanstalk 35 ~ 45 parts, Flos Symplocoris Caudatae 10 ~ 20 Fen ， Folium piperis betlis 15 ~ 25 parts, Radix Cacaliae Tanguticae 15 ~ 25 parts, Radix Thesii 35 ~ 45 parts, black nylon yarn 15 ~ 25 parts, Caulis et Folium Clematidis Breviscudatae 5 ~ 15 parts, Herba vallisneriae Spiralis 10 ~ 20 parts and Herba Lysionoti Pauciflori 10 ~ 20 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Semen Alpiniae Katsumadai 5 ~ 10 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 10 parts, Fructus Litseae pungentis 10 ~ 15 parts, Fructus Manglietiae insignis 5 ~ 10 parts, water wolf beanstalk 35 ~ 40 parts, Flos Symplocoris Caudatae 10 ~ 15 Fen ， Folium piperis betlis 15 ~ 20 parts, Radix Cacaliae Tanguticae 15 ~ 20 parts, Radix Thesii 35 ~ 40 parts, black nylon yarn 15 ~ 20 parts, Caulis et Folium Clematidis Breviscudatae 5 ~ 10 parts, Herba vallisneriae Spiralis 10 ~ 15 parts and Herba Lysionoti Pauciflori 10 ~ 15 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Semen Alpiniae Katsumadai 6 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 8 parts, Fructus Litseae pungentis 12 parts, Fructus Manglietiae insignis 7 parts, water wolf beanstalk 38 parts, Flos Symplocoris Caudatae 14 Fen ， Folium piperis betlis 16 parts, Radix Cacaliae Tanguticae 19 parts, Radix Thesii 36 parts, black nylon yarn 17 parts, Caulis et Folium Clematidis Breviscudatae 8 parts, Herba vallisneriae Spiralis 11 parts and Herba Lysionoti Pauciflori 14 parts.
5. the Chinese medicine as described in Claims 1-4, is characterized in that, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step: each for described Chinese medicine component is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 80 ~ 90%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.5 times, the lactose of 0.05 ~ 0.1 times, the starch of 0.1 ~ 0.5 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.
6. the Chinese medicine as described in Claims 1-4, is characterized in that, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85 ~ 95%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 200 order ~ 300 object micropowders;
3rd step: add the starch relative to its quality 3 ~ 5 times in the micropowders obtained by second step, mixing, obtains powder.
7. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine component is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 80 ~ 90%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.5 times, the lactose of 0.05 ~ 0.1 times, the starch of 0.1 ~ 0.5 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.
8. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85 ~ 95%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 200 order ~ 300 object micropowders;
3rd step: add the starch relative to its quality 3 ~ 5 times in the micropowders obtained by second step, mixing, obtains powder.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836389A (en) * | 2012-09-06 | 2012-12-26 | 许梅 | Traditional Chinese medicine composition for improving postpartum hypogalactia and preparation method thereof |
| CN105031332A (en) * | 2015-07-07 | 2015-11-11 | 闫花英 | Traditional Chinese medicine composition for treating milk obstruction caused by internal retention of phlegm and dampness |
| CN105106504A (en) * | 2015-08-28 | 2015-12-02 | 安徽省颍上县中医院 | Traditional Chinese medicine decoction for promoting lactation of postnatal women |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836389A (en) * | 2012-09-06 | 2012-12-26 | 许梅 | Traditional Chinese medicine composition for improving postpartum hypogalactia and preparation method thereof |
| CN105031332A (en) * | 2015-07-07 | 2015-11-11 | 闫花英 | Traditional Chinese medicine composition for treating milk obstruction caused by internal retention of phlegm and dampness |
| CN105106504A (en) * | 2015-08-28 | 2015-12-02 | 安徽省颍上县中医院 | Traditional Chinese medicine decoction for promoting lactation of postnatal women |
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Application publication date: 20160309 |