CN105381191A - 一种百合润肺止咳片及其制备方法 - Google Patents
一种百合润肺止咳片及其制备方法 Download PDFInfo
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- CN105381191A CN105381191A CN201510839336.1A CN201510839336A CN105381191A CN 105381191 A CN105381191 A CN 105381191A CN 201510839336 A CN201510839336 A CN 201510839336A CN 105381191 A CN105381191 A CN 105381191A
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- herba
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- bulbus lilii
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Abstract
<b>一种百合润肺止咳片及其制备方法，由中药提取物、填充剂、崩解剂、粘合剂、润滑剂、矫味剂、助流剂制成，所述的中药提取物中原料的优选重量份数为：百合30-45份、铁苋15-25份、葫芦茶15-25份、叶上花7-14份、牛蒡7-14份、紫苏叶7-14份、四籽马蓝3-6份、干贝3-6份、桂枝3-6份、当门子3-6份。其制备方法的主要步骤为：（1）制备中药提取物：a、原料预处理；b、制备混合提取液；c、过滤、浓缩、干燥；（2）制备百合润肺止咳片：a、混合；b、干燥；c、混合。本发明的一种百合润肺止咳片，长期服用具有润肺止咳、祛风除湿；活血解毒的功效。</b>
Description
技术领域
本发明涉及一种保健品，特别是一种百合润肺止咳片及其制备方法。
背景技术
在现代医学当中，并没有“润肺”、“清肺”的概念，这里的“润”通俗理解为“滋润”，中医认为，肺乃娇脏，润肺有助肺部的保健；而中医上“清肺”也不是“清理肺部”的意思，中医提到“清肺”的时候前面一般还有“养阴”两个字，意思是滋养阴液，清除肺热、肺火，临床表现为干咳少痰、咽燥咯血、咳嗽气喘、鼻干唇燥等症状的患者便需要养阴清肺。
从中医的角度，百合、梨等食物的确有“润肺”的作用，但是不代表能保护帮助人体抵御污染。中医的“肺”与西医的“肺”所指还是有区别的。中医所指的肺不单单指一个器官，比如中医认为“肺主行水”，比较通俗地说是指肺气有推动和调节全身水液的输布和排泄的功能。
目前，市场上润肺止咳的药物或是保健品有很多，但是大多数药物的效果并不是很好，并且大多数药物的副作用较多，会对人体健康造成伤害，保健品虽有一定的效果，但是其价格高昂，因此，市场上急需一种纯天然、无毒副作用的百合润肺止咳片及其制备方法。
发明内容
本发明的目的是提供一种百合润肺止咳片及其制备方法，长期服用具有润肺止咳、祛风除湿；活血解毒的功效。
本发明的目的通过以下技术方案来实现：
一种百合润肺止咳片，由中药提取物、填充剂、崩解剂、粘合剂、润滑剂、矫味剂、助流剂制成，按重量百分比，中药提取物20-60%、填充剂20-50%、崩解剂10-40%、粘合剂1-20%、润滑剂1-5%、矫味剂1-5%、助流剂1-5%；按重量份数，中药提取物20-60份、填充剂20-50份、崩解剂10-40份、粘合剂1-20份、润滑剂1-5份、矫味剂1-5份、助流剂1-5份。
所述的一种百合润肺止咳片，按最佳重量份数，中药提取物40份、填充剂30份、崩解剂15份、粘合剂5份、润滑剂4份、矫味剂3份、助流剂3份。
所述的中药提取物中原料的优选重量份数为：百合30-45份、铁苋15-25份、葫芦茶15-25份、叶上花7-14份、牛蒡7-14份、紫苏叶7-14份、四籽马蓝3-6份、干贝3-6份、桂枝3-6份、当门子3-6份。
所述的中药提取物中原料的最佳重量份数为：百合40份、铁苋20份、葫芦茶18份、叶上花14份、牛蒡10份、紫苏叶7份、四籽马蓝6份、干贝5份、桂枝4份、当门子3份。
所述的填充剂为微晶纤维素、淀粉、乳糖、糊精、蔗糖中的一种或几种的混合；所述的崩解剂为低取代羟丙纤维素；所述的粘合剂为淀粉浆或聚维酮k30或羟丙甲纤维素；所述的润滑剂为硬脂酸镁、十二烷基硫酸钠中的一种或两种的混合；所述的矫味剂为阿司帕坦、甜菊素、枸橼酸、香精中的一种或几种的混合；所述的助流剂为二氧化硅、滑石粉中的一种或两种的混合。
所述的一种百合润肺止咳片及其制备方法，其特征在于：其制备方法的主要步骤为：
（1）制备中药提取物：
a、原料预处理：按重量份数，选取百合、铁苋、葫芦茶、叶上花、牛蒡、紫苏叶、四籽马蓝、干贝、桂枝、当门子，洗净并除杂，备用；
b、制备混合提取液：将百合、铁苋、葫芦茶、叶上花、牛蒡、紫苏叶、四籽马蓝、干贝、桂枝、当门子混合均匀，然后用水煎煮三次，第一次加14倍的水，中火煎煮2-3小时，过滤，提取滤液，第二次加12倍的水，中火煎煮1.5-2小时，过滤，提取滤液，第三次加10的水大火煎煮0.5小时，过滤，提取滤液，合并三次滤液，得到混合提取液，备用；
c、过滤、浓缩、干燥：取混合提取液，过滤，然后进行减压浓缩，浓缩至60℃时，相对密度为1.22-1.3的清膏，然后置于喷雾干燥机中进行喷雾干燥，干燥后置于粉碎机中粉碎，过60目筛，得到中药提取物；
（2）制备百合润肺止咳片：
a、混合：按重量份数，取中药提取物、填充剂、崩解剂混合均匀，然后置于湿法制粒机中，将粘合剂放入供液槽中，开启机器，调整参数，同时开启剪切飞刀，2-5分钟，出料，使用摇摆式制粒机，过16目尼龙筛网制粒，制得湿颗粒；
b、干燥：将湿颗粒置于烘干机中烘干，烘干后采用紫外线灭菌，得到整粒；
c、混合：将整粒、润滑剂、矫味剂、助流剂混合，置于三维运动混合机中混合15-25分钟，然后使用旋转压片机压片，制得一种百合润肺止咳片。
在药物中：百合，润肺止咳，清心安神；治肺费久嗽，咳唾痰血；热病后余热来清，虚烦惊悸，神志恍惚；脚气浮肿；铁苋，清热解毒，消积，止痢，止血；用于肠炎，细菌性痢疾，阿米巴痢疾，小儿疳积，肝炎，疟疾，吐血，衄血，尿血，便血，子宫出血；外用治痈疖疮疡，外伤出血，湿疹，皮炎，毒蛇咬伤；月经不调，崩漏；葫芦茶，清热，利湿，消滞，杀虫；治感冒，咽痛，肺病咳血，肠炎，痢疾，黄疸，风湿关节痛，钩虫病，妊娠呕吐，小儿疳积，疮疥；叶上花，祛风除湿；活血解毒；活血化瘀，清热解毒；用于跌打损伤，骨折，风湿性关节炎，胃痛，痢疾，月经不调；外用治烧烫伤，疮疖痈肿，毒蛇咬伤；牛蒡，疏散风热，宣肺透疹，消肿解毒；治风热咳嗽，咽喉肿痛，斑疹不透，风疹作痒，痈肿疮毒；紫苏叶，发表，散寒，理气，和营；治感冒风寒，恶寒发热，咳嗽，气喘，胸腹胀满，胎动不安；并能解鱼蟹毒；四籽马蓝，清热解毒、凉血、生津、利尿作用的功效；用治实热内结之热毒斑疹、便血、小便不利、肿毒疔疮等症；外用可用治跌打损伤、红肿出血；干贝，滋阴补肾、和胃调中功能，能治疗头晕目眩、咽干口渴、虚痨咳血、脾胃虚弱等症，常食有助于降血压、降胆固醇、补益健身；据记载，干贝还具有抗癌、软化血管、防止动脉硬化等功效；香附理气解郁，止痛调经；治肝胃不和，气郁不舒，胸腹胁肋胀痛，痰饮痞满，月经不调，崩漏带下；桂枝，发汗解肌，温经通脉；治风寒表证，肩背肢节酸疼，胸痹痰饮，经闭癥瘕。
本发明的有益效果：本发明的一种百合润肺止咳片，以祖传秘方为基础，精选百合、铁苋、葫芦茶、叶上花、牛蒡、紫苏叶、四籽马蓝、干贝、桂枝、当门子、等原料进行组合，使得各种药物的药效产生协同作用，从而能够达到效果，长期服用具有润肺止咳、疏散风热，宣肺透疹的功效。
本发明经两组临床验证，其中一组为治疗组服用本发明，每天服用本发明一次，7天为一个疗程，另一组对照组服用润肺止咳胶囊，每天使用一次，7天为一个疗程，每组选择门诊病人52例，其中男32例，女20例，最大年龄75岁，最小年龄35岁，临床表现为脘腹胀满、阿米巴痢疾，外伤出血，表一为服用一个疗程后的对照数据：
表1服用前后两组疗程比较(单位:人)
治疗组和对照组有显著差异，从而可以看出本发明在临床上的应用有显著的疗效。
本发明的工艺优点在于：1、选择原料科学，生产工艺先进；2、产品中不添加香料及防腐剂，保持原料本身的风味和营养成份，易被人体吸收；3、原料来源广泛，加工艺线路短，产品易加工制造。
具体实施方式
实施例1
一种百合润肺止咳片，由中药提取物、填充剂、崩解剂、粘合剂、润滑剂、矫味剂、助流剂制成，按重量百分比，中药提取物20-60%、填充剂20-50%、崩解剂10-40%、粘合剂1-20%、润滑剂1-5%、矫味剂1-5%、助流剂1-5%；按重量份数，中药提取物20-60份、填充剂20-50份、崩解剂10-40份、粘合剂1-20份、润滑剂1-5份、矫味剂1-5份、助流剂1-5份。
所述的一种百合润肺止咳片，按最佳重量份数，中药提取物40份、填充剂30份、崩解剂15份、粘合剂5份、润滑剂4份、矫味剂3份、助流剂3份。
所述的中药提取物中原料的优选重量份数为：百合30-45份、铁苋15-25份、葫芦茶15-25份、叶上花7-14份、牛蒡7-14份、紫苏叶7-14份、四籽马蓝3-6份、干贝3-6份、桂枝3-6份、当门子3-6份。
所述的中药提取物中原料的最佳重量份数为：百合40份、铁苋20份、葫芦茶18份、叶上花14份、牛蒡10份、紫苏叶7份、四籽马蓝6份、干贝5份、桂枝4份、当门子3份。
所述的填充剂为微晶纤维素、淀粉、乳糖、糊精、蔗糖中的一种或几种的混合；所述的崩解剂为低取代羟丙纤维素；所述的粘合剂为淀粉浆或聚维酮k30或羟丙甲纤维素；所述的润滑剂为硬脂酸镁、十二烷基硫酸钠中的一种或两种的混合；所述的矫味剂为阿司帕坦、甜菊素、枸橼酸、香精中的一种或几种的混合；所述的助流剂为二氧化硅、滑石粉中的一种或两种的混合。
所述的一种百合润肺止咳片及其制备方法，其制备方法的主要步骤为：
（1）制备中药提取物：
a、原料预处理：按重量份数，选取百合、铁苋、葫芦茶、叶上花、牛蒡、紫苏叶、四籽马蓝、干贝、桂枝、当门子，洗净并除杂，备用；
b、制备混合提取液：将百合、铁苋、葫芦茶、叶上花、牛蒡、紫苏叶、四籽马蓝、干贝、桂枝、当门子混合均匀，然后用水煎煮三次，第一次加14倍的水，中火煎煮2-3小时，过滤，提取滤液，第二次加12倍的水，中火煎煮1.5-2小时，过滤，提取滤液，第三次加10的水大火煎煮0.5小时，过滤，提取滤液，合并三次滤液，得到混合提取液，备用；
c、过滤、浓缩、干燥：取混合提取液，过滤，然后进行减压浓缩，浓缩至60℃时，相对密度为1.22-1.3的清膏，然后置于喷雾干燥机中进行喷雾干燥，干燥后置于粉碎机中粉碎，过60目筛，得到中药提取物；
（2）制备百合润肺止咳片：
a、混合：按重量份数，取中药提取物、填充剂、崩解剂混合均匀，然后置于湿法制粒机中，将粘合剂放入供液槽中，开启机器，调整参数，同时开启剪切飞刀，2-5分钟，出料，使用摇摆式制粒机，过16目尼龙筛网制粒，制得湿颗粒；
b、干燥：将湿颗粒置于烘干机中烘干，烘干后采用紫外线灭菌，得到整粒；
c、混合：将整粒、润滑剂、矫味剂、助流剂混合，置于三维运动混合机中混合15-25分钟，然后使用旋转压片机压片，制得一种百合润肺止咳片。
Claims (6)
1.一种百合润肺止咳片，其特征在于：由中药提取物、填充剂、崩解剂、粘合剂、润滑剂、矫味剂、助流剂制成，按重量百分比，中药提取物20-60%、填充剂20-50%、崩解剂10-40%、粘合剂1-20%、润滑剂1-5%、矫味剂1-5%、助流剂1-5%；按重量份数，中药提取物20-60份、填充剂20-50份、崩解剂10-40份、粘合剂1-20份、润滑剂1-5份、矫味剂1-5份、助流剂1-5份。
2.根据权利要求1所述的一种百合润肺止咳片，其特征在于：按最佳重量份数，中药提取物40份、填充剂30份、崩解剂15份、粘合剂5份、润滑剂4份、矫味剂3份、助流剂3份。
3.根据权利要求1所述的一种百合润肺止咳片，其特征在于：所述的中药提取物中原料的优选重量份数为：百合30-45份、铁苋15-25份、葫芦茶15-25份、叶上花7-14份、牛蒡7-14份、紫苏叶7-14份、四籽马蓝3-6份、干贝3-6份、桂枝3-6份、当门子3-6份。
4.根据权利要求1所述的一种百合润肺止咳片，其特征在于：所述的中药提取物中原料的最佳重量份数为：百合40份、铁苋20份、葫芦茶18份、叶上花14份、牛蒡10份、紫苏叶7份、四籽马蓝6份、干贝5份、桂枝4份、当门子3份。
5.根据权利要求1-4所述的一种百合润肺止咳片及其制备方法，其特征在于：所述的填充剂为微晶纤维素、淀粉、乳糖、糊精、蔗糖中的一种或几种的混合；所述的崩解剂为低取代羟丙纤维素；所述的粘合剂为淀粉浆或聚维酮k30或羟丙甲纤维素；所述的润滑剂为硬脂酸镁、十二烷基硫酸钠中的一种或两种的混合；所述的矫味剂为阿司帕坦、甜菊素、枸橼酸、香精中的一种或几种的混合；所述的助流剂为二氧化硅、滑石粉中的一种或两种的混合。
6.根据权利要求1所述的一种百合润肺止咳片及其制备方法，其特征在于：其制备方法的主要步骤为：
（1）制备中药提取物：
a、原料预处理：按重量份数，选取百合、铁苋、葫芦茶、叶上花、牛蒡、紫苏叶、四籽马蓝、干贝、桂枝、当门子，洗净并除杂，备用；
b、制备混合提取液：将百合、铁苋、葫芦茶、叶上花、牛蒡、紫苏叶、四籽马蓝、干贝、桂枝、当门子混合均匀，然后用水煎煮三次，第一次加14倍的水，中火煎煮2-3小时，过滤，提取滤液，第二次加12倍的水，中火煎煮1.5-2小时，过滤，提取滤液，第三次加10的水大火煎煮0.5小时，过滤，提取滤液，合并三次滤液，得到混合提取液，备用；
c、过滤、浓缩、干燥：取混合提取液，过滤，然后进行减压浓缩，浓缩至60℃时，相对密度为1.22-1.3的清膏，然后置于喷雾干燥机中进行喷雾干燥，干燥后置于粉碎机中粉碎，过60目筛，得到中药提取物；
（2）制备百合润肺止咳片：
a、混合：按重量份数，取中药提取物、填充剂、崩解剂混合均匀，然后置于湿法制粒机中，将粘合剂放入供液槽中，开启机器，调整参数，同时开启剪切飞刀，2-5分钟，出料，使用摇摆式制粒机，过16目尼龙筛网制粒，制得湿颗粒；
b、干燥：将湿颗粒置于烘干机中烘干，烘干后采用紫外线灭菌，得到整粒；
c、混合：将整粒、润滑剂、矫味剂、助流剂混合，置于三维运动混合机中混合15-25分钟，然后使用旋转压片机压片，制得一种百合润肺止咳片。
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