CN105381165A - Traditional Chinese medicine composition for treating hypomenorrhea caused by intrauterine adhesion after cold-stasis collateral blocking type intrauterine operation - Google Patents

Abstract

The invention belongs to the technical field of medicament, and in particular relates to a traditional Chinese medicine composition for treating hypomenorrhea caused by intrauterine adhesion after a cold-stasis collateral blocking type intrauterine operation. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 4 to 8 parts of illicium verum, 4 to 8 parts of rhizoma cacaliae davidii, 4 to 8 parts of Jordan almond, 4 to 8 parts of Aralia undulata Hand.-Mazz., 4 to 8 parts of Arisaema faregesii Buchet, 4 to 8 parts of whitewood, 4 to 8 parts of pericarp of common sterculia, 4 to 8 parts of alyxia sinensis and 4 to 8 parts of glycyrrhiza uralensis. According to the traditional Chinese medicine composition for treating hypomenorrhea caused by the intrauterine adhesion after the cold-stasis collateral blocking type intrauterine operation, disclosed by the invention, all the traditional Chinese medicines work together, and the effects of warming yang and dredging collaterals as well as promoting blood circulation and removing blood stasis are obtained; focusing on the etiology and pathogenesis of hypomenorrhea caused by the intrauterine adhesion, the menstrual blood volume of a patient can be obviously increased, and concomitant Chinese medicinal symptoms can be improved.

Description

A kind of Chinese medicine composition for the treatment of hypomenorrhea caused by the postoperative intrauterine adhesion of cold stasis blocking network type intrauterine surgical

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition for the treatment of hypomenorrhea caused by the postoperative intrauterine adhesion of cold stasis blocking network type intrauterine surgical.

Background technology

Intrauterine adhesion, refers to uterus tract, comprises the adhesion of cavity of uterus portion, isthmus uteri and cervical canal.Cause primarily of intrauterine surgical operation, particularly artificial abortion operation.Clinical manifestation, based on hypomenorrhea even amenorrhea, also comprises secondary infertility, periodic abdominalgia, habitual abortion etc.Increasing because of pregnant before marrige, artificial abortion, medicine stream etc., and the increase of genital system infection disease at present, the sickness rate of intrauterine adhesion has the trend of increase.

Hypomenorrhea refers to that menstrual cycle is normal, and menstrual blood loss comparatively constant obviously reduces, and even drop is namely clean, or through the not enough sky of line time, through the menopathy that amount is also few.It is generally acknowledged Hypomenorrhea in 30ml be hypomenorrhea.Hypomenorrhea makes patient not become pregnant or germ cell can not implantation and normal growth be grown because of Endometrial Diseases, thus causes the generation of infertility.The postoperative intrauterine adhesion of intrauterine surgical usually causes hypomenorrhea, and threaten patient's fertility, current Western medicine there is no effective Therapeutic Method to this, therefore, finds a comparatively effective Therapeutic Method and has positive clinical meaning and social meaning.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of Chinese medicine composition for the treatment of hypomenorrhea caused by the postoperative intrauterine adhesion of cold stasis blocking network type intrauterine surgical.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine composition for hypomenorrhea caused by the postoperative intrauterine adhesion of cold stasis blocking network type intrauterine surgical, be made up of the Chinese medicine of following weight portion:

Fructus Anisi Stellati 4-8 part, red Radix Aconiti 4-8 part, Semen Armeniacae Dulcis 4-8 part, Radix Araliae undulatae 4-8 part, Eriocheir sinensis seven 4-8 part, Rhizoma Atractylodis macrocephalae 4-8 part, Pericarpium Sterculiae nobilis 4-8 part, Herba Alyxiae Sinensis 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, above-mentioned treatment is trembled with fear the Chinese medicine composition of hypomenorrhea caused by the postoperative intrauterine adhesion of stasis blocking network type intrauterine surgical, is made up of the Chinese medicine of following weight portion:

Fructus Anisi Stellati 5-7 part, red Radix Aconiti 5-7 part, Semen Armeniacae Dulcis 5-7 part, Radix Araliae undulatae 5-7 part, Eriocheir sinensis seven 5-7 part, Rhizoma Atractylodis macrocephalae 5-7 part, Pericarpium Sterculiae nobilis 5-7 part, Herba Alyxiae Sinensis 5-7 part, Radix Glycyrrhizae 5-7 part.

Preferred, above-mentioned treatment is trembled with fear the Chinese medicine composition of hypomenorrhea caused by the postoperative intrauterine adhesion of stasis blocking network type intrauterine surgical, is made up of the Chinese medicine of following weight portion:

Fructus Anisi Stellati 6 parts, red Radix Aconiti 6 parts, Semen Armeniacae Dulcis 6 parts, Radix Araliae undulatae 6 parts, Eriocheir sinensis 76 parts, Rhizoma Atractylodis macrocephalae 6 parts, Pericarpium Sterculiae nobilis 6 parts, Herba Alyxiae Sinensis 6 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of hypomenorrhea caused by the postoperative intrauterine adhesion of cold stasis blocking network type intrauterine surgical.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In Chinese medicine composition of the present invention,

Fructus Anisi Stellati is the dry mature fruit of Magnoliacea plant Fructus Anisi Stellati IlliciumverumHook.f..Acrid in the mouth, warm in nature.Return liver,kidney,spleen, stomach warp.Function warming YANG to expel cold, regulating QI to relieve pain.For colic of cold type stomachache, lumbago due to renal deficiency, gastrofrigid vomiting, coldness and pain in the epigastrium.

Red Radix Aconiti another name Dobinea delavayi, xanthate root are feverfew Radix Cacaliae davidii Cacaliadauidii (Franch.) Hand.-Mazz. [SeneciodauidiiFranch.; Sinacaliadauidii (Franch.) Hand.-Mazz.] tuber.Acrid in the mouth; Warm in nature.Function expelling wind and removing dampness; Cold expelling dredging collateral.Main air damp lumbago; Rheumatism completes paralysis; Hemiplegia; Headache; Head sore is bald in vain; Traumatic injury.

Semen Armeniacae Dulcis another name eight load core, Ba Da Semen Armeniacae Amarum, rattle away Semen Armeniacae Amarum, Amygdaluscommunis L., partially Fructus Persicae, the light tree of mother-in-law, partially Semen Juglandis, plaque Fructus Persicae, neglect deer fiber crops, capital Fructus Pruni.For rosaceous plant almond seed.Latin plant animal mineral name: AmygdaluspersicaL. [prunuspersica (L.) Batsch.].Bitter in the mouth, sweet, GUIXIN, liver, large intestine channel.Function blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.Main dysmenorrhea, amenorrhea due to stagnation of blood, the stagnant stomachache of the stasis of blood in puerperal, traumatic injury, swelling and pain due to blood stasis, pain in the lung, enterodynia, dryness of the intestine constipation.

Radix Araliae undulatae another name HONGCI brain bag, sky, top thorn, Aralia mandshurica, Sedum aizoon L., purplish red umbrella are the root of Araliaceae Radix Araliae undulatae AraliaundulataHand.-Mazz.Bitter in the mouth; Pungent; Cool in nature.Function blood circulation promoting and blood stasis dispelling; Inducing menstruation to relieve menalgia; Expelling wind and removing dampness.Main traumatic injury; Fracture; Mass in the abdomen; Amenorrhea; Dysmenorrhea; Impairment caused by overstrain pain; Rheumatalgia.

Eriocheir sinensis seven calls few fringe Radix et rhizoma smilacinae japonicae, few Honoka, ferrum cripple, derives from Liliaceae Smilacina plant tube flower Radix et rhizoma smilacinae japonicae Smilacinahenryi(Baker) WangetTang, is used as medicine with root stock and root.Sweet in the mouth, warm in nature.Function temperature male wind-supplying kidney, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling.For sexual impotence, traumatic injury, Fengshi Guanjie pain.

Rhizoma Atractylodis macrocephalae calls Folium seu Radix Clausenae dentatae, Ovum Gallus domesticus Flavus, little Citrus chachiensis Hort., Radix araliae armatae, puts loose, wild Fructus Capsici on the skin.For rutaceae bassoon Micromelumfalcatum(Lour.) root of Tanaka [AulasiafalcatumLour.] or leaf.Acrid in the mouth; Bitter; Warm in nature.Return liver; Kidney channel.Function blood-activating and qi-promoting; Eliminating stasis to stop pain.The main thoracic obstruction; Treating swelling and pain by traumatic injury; Fracture; Sprain; Rheumatic arthralgia; Wait pain; Venom.

Pericarpium Sterculiae nobilis another name Semen Sterculiae Nobilis pod, sterculia nobilis's shell.For the shell of Sterculiaceae plant sterculia nobilis SterculianobilisSmith.Sweet in the mouth; Property is put down.Return small intestine meridian.Function blood-activating and qi-promoting.Main dysentery; Inguinal hernia; Hemorrhoid; Otitis media.

Herba Alyxiae Sinensis another name beads rattan, Semen Benincasae rattan, Semen Benincasae English, feather tree, Clausena excavata Burm.f., Herba Alyxiae Sinensis, excessively bone limit, Herba Polygalae Japonicae, Radix Buddlejae Butterflybush.Derive from herb and the root of apocynaceae plant chain pearl rattan.Bitter in the mouth is pungent, warm in nature.Function expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.Treating rheumatic arthralgia, diarrhea due to hypofunction of the spleen, beriberi, general edema, married woman's amenorrhea, traumatic injury.

Radix Glycyrrhizae is sweet, flat.GUIXIN, lung, spleen, stomach warp.Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

" intrauterine adhesion " is not recorded in traditional Chinese medical science tradition ancient books.In uterine cavity, operation technique easily damages venation, and nutrient blood is excessive, and blood circulating out of vessels is blood stasis, and the only internal resistance of the stasis of blood, with the passing of time causes the stagnation of QI, and blood stasis and the stagnation of QI are sick each other mutually, and cause punching to appoint QI-blood circulation not smooth, with the passing of time zang-fu differentiation disorder of QI and blood, sends out as primary disease.In addition, in puerperal in menstrual period, experience cold-evil, or eating cold and uncooked food excessively, cold-evil lies prostrate and appoints in punching, and blood is for cold stagnant, and run not smooth, sea of blood spill-over is few, causes through row amount few, can cause primary disease." cold stasis blocking network " is the Basic disease cause pathogenesis of primary disease, and treatment is worked as with warming YANG dredging collateral, and blood circulation promoting and blood stasis dispelling is method.

Chinese medicine composition of the present invention, its prescription mechanism is as follows:

Monarch drug: Fructus Anisi Stellati, red Radix Aconiti merit are with warming YANG to expel cold dredging collateral.

Ministerial drug: Semen Armeniacae Dulcis, Radix Araliae undulatae merit are with blood circulation promoting and blood stasis dispelling.

Adjuvant drug: Eriocheir sinensis seven merit is with the kidney invigorating warming YANG, and Rhizoma Atractylodis macrocephalae, Pericarpium Sterculiae nobilis merit are with blood-activating and qi-promoting; Herba Alyxiae Sinensis merit is with promoting blood circulation to remove obstruction in the collateral.

Make medicine: Radix Glycyrrhizae merit is with coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share plays warming YANG dredging collateral, the effect of blood circulation promoting and blood stasis dispelling altogether, the etiology and pathogenesis of hypomenorrhea caused by intrauterine adhesion (the cold stasis blocking network type) that link closely, obviously can increase the menstrual blood volume of patient and improve with TCM syndrome, clinical efficacy is remarkable, is worthy to be popularized.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine composition for hypomenorrhea caused by the postoperative intrauterine adhesion of cold stasis blocking network type intrauterine surgical, each crude drug weight proportion is as follows:

Fructus Anisi Stellati 6g, red Radix Aconiti 6g, Semen Armeniacae Dulcis 6g, Radix Araliae undulatae 6g, Eriocheir sinensis seven 6g, Rhizoma Atractylodis macrocephalae 6g, Pericarpium Sterculiae nobilis 6g, Herba Alyxiae Sinensis 6g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat a Chinese medicine composition for hypomenorrhea caused by the postoperative intrauterine adhesion of cold stasis blocking network type intrauterine surgical, each crude drug weight proportion is as follows:

Fructus Anisi Stellati 5 parts, red Radix Aconiti 5 parts, Semen Armeniacae Dulcis 5 parts, Radix Araliae undulatae 5 parts, Eriocheir sinensis 75 parts, Rhizoma Atractylodis macrocephalae 5 parts, Pericarpium Sterculiae nobilis 5 parts, Herba Alyxiae Sinensis 5 parts, 5 parts, Radix Glycyrrhizae.

Embodiment 3

Treat a Chinese medicine composition for hypomenorrhea caused by the postoperative intrauterine adhesion of cold stasis blocking network type intrauterine surgical, each crude drug weight proportion is as follows:

Fructus Anisi Stellati 7g, red Radix Aconiti 7g, Semen Armeniacae Dulcis 7g, Radix Araliae undulatae 7g, Eriocheir sinensis seven 7g, Rhizoma Atractylodis macrocephalae 7g, Pericarpium Sterculiae nobilis 7g, Herba Alyxiae Sinensis 7g, Radix Glycyrrhizae 7g.

Embodiment 4

Treat a Chinese medicine composition for hypomenorrhea caused by the postoperative intrauterine adhesion of cold stasis blocking network type intrauterine surgical, each crude drug weight proportion is as follows:

Fructus Anisi Stellati 8g, red Radix Aconiti 8g, Semen Armeniacae Dulcis 8g, Radix Araliae undulatae 8g, Eriocheir sinensis seven 8g, Rhizoma Atractylodis macrocephalae 8g, Pericarpium Sterculiae nobilis 8g, Herba Alyxiae Sinensis 8g, Radix Glycyrrhizae 8g.

Embodiment 5

Treat a Chinese medicine composition for hypomenorrhea caused by the postoperative intrauterine adhesion of cold stasis blocking network type intrauterine surgical, each crude drug weight proportion is as follows:

Fructus Anisi Stellati 4g, red Radix Aconiti 4g, Semen Armeniacae Dulcis 4g, Radix Araliae undulatae 4g, Eriocheir sinensis seven 4g, Rhizoma Atractylodis macrocephalae 4g, Pericarpium Sterculiae nobilis 4g, Herba Alyxiae Sinensis 4g, Radix Glycyrrhizae 4g.

Carried out clinical pharrnacokinetics test to Chinese medicine composition of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose hypomenorrhea caused by intrauterine adhesion (cold stasis blocking network type) patient 210 example.

1.2 diagnostic criteria

(1) hysteroscopy prompting intrauterine adhesion, with reference to the standard that U.S.'s genesiology can be formulated.(2) hypomenorrhea diagnosis meets " obstetrics and gynecology " diagnostic criteria.

1.3 tcm diagnosis standards

Dependent diagnostic standard is formulated with reference to " Gynecology of Chinese Medicine ", " Diagnostics of Chinese Medicine ", " guideline of clinical investigations of new Chinese medicine treatment menoxenia ".Meet the dialectical standard of cold stasis blocking network type:

Cardinal symptom: gradually few through water after intrauterine surgical, or drop is namely clean, and even it is not all right to close down, color purple is dim, accompanies clot.

Minor symptom: cold and pain in the lower abdomen, pain alleviated while getting warmth, aversion to cold and cold limbs, complexion is bluish white.

Tongue arteries and veins: dark tongue quality, or have ecchymosis, petechia, deep and hesitant pulse is tight.

Possess above primary symptom and secondary disease 2 persons, diagnosable is this disease.

1.4 inclusive criteria

(1) intrauterine surgical is had to operate history, especially artificial abortion vacuum suction history;

(2) clinical symptoms of typical hypomenorrhea or amenorrhea is had;

(3) slight or moderate intrauterine adhesion is diagnosed as through hysteroscopy;

(4) traditional Chinese medical science simultaneous phenomenon meets the diagnostic criteria of cold stasis blocking network;

(5) basal body temperature is two-phase, gonadal hormone six no abnormality seens;

(6) enter this research in first 3 months and do not carry out other treatment;

(7) volunteer tested.

1.5 exclusion standard

(1) severe intrauterine adhesion, cervical canal adhesion person;

(2) menoxenia of hypothalamo pituitary hypothalamic pituitary ovarium axis caused by abnormal;

(3) gestation, suckling, menopause etc. physiologic amenorrhea;

(4) hypertension, diabetics, is associated with the serious disease persons such as cardiovascular and cerebrovascular vessel, liver, kidney and hemopoietic system;

(5) reproductive system birth defect or deformity, tuberculosis of reproductive system;

(6) to this drug allergy person.

1.6 stop and the standard that comes off

(1) automatically require to exit treatment, can not supporter.

(2) there is side reaction or other serious adverse reactions in observation process, can not resistance to receptor.

(3) experimenter does not take medicine on time, and causes judging curative effect, or other adverse events, complications occur

1.7 Therapeutic Method

Give the Chinese medicine of the embodiment of the present invention 1, prescription is as follows: Fructus Anisi Stellati 6g, red Radix Aconiti 6g, Semen Armeniacae Dulcis 6g, Radix Araliae undulatae 6g, Eriocheir sinensis seven 6g, Rhizoma Atractylodis macrocephalae 6g, Pericarpium Sterculiae nobilis 6g, Herba Alyxiae Sinensis 6g, Radix Glycyrrhizae 6g, be decocted in water for oral dose, day potion, sooner or later sub-service was a course for the treatment of with 1 week.

1.8 the standard of curative effect evaluation

Cure: menstruation recovery is normal, under hysteroscope, uterine cavity shape is normal, and intimal surface is smooth, angle, bilateral palace or fallopian tube opening high-visible.

Effective: hyper-menorrhea, but still comparatively previously reduce, under hysteroscope, uterine cavity shape is normal, still visible part adhesion.

Invalid: menstruation does not recover, under hysteroscope uterine cavity shape be separated front unchanged.

1.9 TCM syndrome scorings

TCM syndrome integral estimation is with reference to relevant criterion in " new Chinese medicine guideline of clinical investigations ", and according to nothing 0 point, slight 1 point, moderate 2 points, severe 3 points is scored.

1.10 statistical method

Adopt SPSS14.0 version statistics software to process, before and after treatment, TCM syndrome integration represents with mean plus-minus standard deviation, compares and adopts t inspection, represent that difference has statistical significance with P<0.05 between group.

2. result

2.1 clinical efficacy

Hypomenorrhea caused by 210 routine intrauterine adhesion (cold stasis blocking network type) patient healing person 193 example, effective 16 examples, invalid 1 example, cure rate 91.9%, 99.5%.

TCM syndrome integration before and after 2.2 treatments

Before treatment, TCM syndrome integration is (24.48 ± 6.47) point, and be reduced to after treatment (6.35 ± 1.56) point, difference has statistical significance (t=2.463, P<0.05).

Claims (3)

1. treat a Chinese medicine composition for hypomenorrhea caused by the postoperative intrauterine adhesion of cold stasis blocking network type intrauterine surgical, be made up of the Chinese medicine of following weight portion:

Fructus Anisi Stellati 4-8 part, red Radix Aconiti 4-8 part, Semen Armeniacae Dulcis 4-8 part, Radix Araliae undulatae 4-8 part, Eriocheir sinensis seven 4-8 part, Rhizoma Atractylodis macrocephalae 4-8 part, Pericarpium Sterculiae nobilis 4-8 part, Herba Alyxiae Sinensis 4-8 part, Radix Glycyrrhizae 4-8 part.

2. treatment according to claim 1 is trembled with fear the Chinese medicine composition of hypomenorrhea caused by the postoperative intrauterine adhesion of stasis blocking network type intrauterine surgical, it is characterized in that, is made up of the Chinese medicine of following weight portion:

Fructus Anisi Stellati 5-7 part, red Radix Aconiti 5-7 part, Semen Armeniacae Dulcis 5-7 part, Radix Araliae undulatae 5-7 part, Eriocheir sinensis seven 5-7 part, Rhizoma Atractylodis macrocephalae 5-7 part, Pericarpium Sterculiae nobilis 5-7 part, Herba Alyxiae Sinensis 5-7 part, Radix Glycyrrhizae 5-7 part.

3. treatment according to claim 3 is trembled with fear the Chinese medicine composition of hypomenorrhea caused by the postoperative intrauterine adhesion of stasis blocking network type intrauterine surgical, it is characterized in that, is made up of the Chinese medicine of following weight portion:

Fructus Anisi Stellati 6 parts, red Radix Aconiti 6 parts, Semen Armeniacae Dulcis 6 parts, Radix Araliae undulatae 6 parts, Eriocheir sinensis 76 parts, Rhizoma Atractylodis macrocephalae 6 parts, Pericarpium Sterculiae nobilis 6 parts, Herba Alyxiae Sinensis 6 parts, 6 parts, Radix Glycyrrhizae.