CN105380167A - 一种化血胆利肝护胆颗粒及其制备方法 - Google Patents
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Abstract
<b>一种化血胆利肝护胆颗粒及其制备方法，涉及一种保健颗粒，由原料按以下重量份数制成，化血胆25-30份、鸡骨香20-25份、白叶火草15-18份、白芷13-17份、葛花12-16份、山梗菜10-13份、菊苣8-10份、青龙藤5-8份、刺瓜米草3-5份、蔬菜粉30-35份、辅料3-5份；所述辅料，由原料按以下重量份数制成，纤维素酶1-1.5份、苹果酸0.5-1份、蔗糖1-1.5份、阿拉伯胶0.5-1份；具体制备工序：（1）原料预处理；（2）制备中药液；（3）制备蔬菜粉；（4）混合制粒；（5）干燥。本发明营养价值高，食用安全性高，长期食用，具有利肝护胆、平肝利胆、清热解毒之效，适宜大众人群。</b>
Description
技术领域
本发明涉及一种保健颗粒，特别是涉及一种化血胆利肝护胆颗粒及其制备方法。
背景技术
肝胆湿热，是指湿热之邪蕴结肝胆的病证，多由外感湿热之邪，或湿邪内生，郁久化热所致。多因受湿热之邪或脾虚水湿内生，日久化热，或长期食用过多甘肥厚味生湿助热，进而影响肝胆功能所致。临床表现为：腹胀、口苦、恶心呕吐、舌红苔黄、身目发黄。
随着生活水平的提高，很多人不节制饮食，膳食结构里油腻食物占主导，且经常熬夜、不运动，加之精神压力等因素的影响，出现了一系列肝胆湿热的症候。于是，市面上各类保肝护胆、清热利湿的保健品，相继出现，但这些保健品大多无实际效用，空有噱头罢了，不建议使用。
发明内容
本发明的目的在于提供一种化血胆利肝护胆颗粒及其制备方法，通过该方法制得的产品，安全无毒副作用，且长期食用，具有平肝、解毒、清热利胆的功效。
本发明的目的通过以下技术方案实现：
一种化血胆利肝护胆颗粒，由原料按以下重量份数制成，化血胆25-30份、鸡骨香20-25份、白叶火草15-18份、白芷13-17份、葛花12-16份、山梗菜10-13份、菊苣8-10份、青龙藤5-8份、刺瓜米草3-5份、蔬菜粉30-35份、辅料3-5份；所述辅料，由原料按以下重量份数制成，纤维素酶1-1.5份、苹果酸0.5-1份、蔗糖1-1.5份、阿拉伯胶0.5-1份。
所述一种化血胆利肝护胆颗粒，原料按最佳重量份数，化血胆28份、鸡骨香20份、白叶火草18份、白芷15份、葛花14份、山梗菜10份、菊苣8份、青龙藤7份、刺瓜米草4份、蔬菜粉30份、辅料4份。
所述一种化血胆利肝护胆颗粒，所述蔬菜粉的原料为凉瓜、油豆、莲藕、木耳、巴西蘑菇中一种或几种的组合。
所述一种化血胆利肝护胆颗粒，所述辅料中原料按最佳重量份数，纤维素酶1.2份、苹果酸0.6份、蔗糖1.5份、阿拉伯胶0.8份。
所述一种化血胆利肝护胆颗粒的制备方法，包括以下工序：
（1）原料预处理：
按重量份数，取优质的化血胆、鸡骨香、白叶火草、白芷、葛花、山梗菜、菊苣、青龙藤、刺瓜米草、蔬菜，洗净，备用；
（2）制备中药液：
按重量份数，取洗净的化血胆、鸡骨香、白叶火草、白芷、葛花、山梗菜、菊苣、青龙藤、刺瓜米草，混合，加入3-5倍饮用水，浸泡12-15小时，使用超声波法进行一次植物细胞破壁；破壁后，再加入纤维素酶，于70-80℃条件下，酶解20-25分钟，过滤，得酶解液；取酶解液，加热至100℃，加热10-15分钟，进行酶失活处理，得中药液；
（3）制备蔬菜粉：
按重量份数，取洗净的蔬菜，根据原料特性，切成条、丝、片状，放入热水中焯煮至熟透，冷却至室温，再置于烘干机内，经脱水干燥得干菜，再将干菜粉碎至200-240目的超微蔬菜粉；
（4）混合制粒：
按重量份数，取中药液、蔬菜粉，置于搅拌机内，再加入苹果酸、蔗糖、阿拉伯胶，混合均匀，得混合物；将混合物置于摇摆制粒机内制粒，得整粒；
（5）干燥：
取工序（4）中得到的整粒，高温干燥至水分含量为2%以下，得干粒；将干粒用振动筛筛选20-30目之间的颗粒，混合装袋，即得成品。
本发明的药物配比，源于传统中医药学中关于“扶正固本”“阴阳协调”的辩证思想，是发明人通过对中医药学潜心研究并根据实践经验，选取传统中药，科学配比、精心加工而成。
在工序中，选取优质的原料并洗净，能提高原料的质量，保障产品食用的安全性；将中药材充分浸润，并利用超声波法进行破壁处理，加入纤维素酶进行酶解，能使药材中的营养元素充分流出；再进行酶失活处理，较好地保证了产品质量的稳定性，将蔬菜熟制、干燥、粉碎成蔬菜粉，减少了生蔬菜的苦涩口感，再佐以辅料，混合制成颗粒，经干燥灭菌、筛选装袋，得成品；其中，采用高温干燥法，在干燥的同时，也达到了灭菌目的，省时省力，有效地节约了成本。
在原料中，化血胆，能祛湿，平肝，散瘀活血；鸡骨香，具有理气止痛，祛风除湿，舒筋的功效；白叶火草，有祛风，清热，利尿作用；白芷，能祛风，燥湿，消肿，止痛；葛花，能解酒醒脾，止血，主治呕逆吐酸，不思饮食；山梗菜，有利水，消肿，解毒作用；菊苣，能清热解毒，利尿消肿；青龙藤，能活血舒筋，理气祛风；刺瓜米草，具有祛风，清热，利湿之效；蔬菜粉，既保留了蔬菜中的营养成分，还包含各种维生素和膳食纤维，能有效补充人体所需各种维生素和微量元素。
本发明的有益效果：本发明的一种化血胆利肝护胆颗粒，营养价值高，食用安全性高，长期食用，具有平肝、清热利胆、清肝的功效，适宜大众人群。
本发明的工艺优点：工艺流程简洁、易操作，工艺科学，不会导致原料中营养元素的流失，选料配比合理，适宜大众人群。
本发明经两组临床验证，其中一组为治疗组，食用本发明，每天食用本发明一次，7天为一个疗程，另一组对照组服用保肝护胆口服液，每天服用一次，7天为一个疗程，每组选择门诊病人100例，其中男30例，女70例，最大年龄75岁，最小年龄25岁，临床表现为腹胀、口苦、恶心呕吐、舌红苔黄、身目发黄，表一为服用一个疗程后的对照数据：
表1服用前后两组疗程比较(单位:人)
治疗组和对照组的有效率有明显差异，不难看出本发明临床应用上的显著疗效。
具体实施方式
下面结合具体实施例对本发明作进一步详细说明。
实施例1
一种化血胆利肝护胆颗粒，由原料按以下重量份数制成，化血胆25-30份、鸡骨香20-25份、白叶火草15-18份、白芷13-17份、葛花12-16份、山梗菜10-13份、菊苣8-10份、青龙藤5-8份、刺瓜米草3-5份、蔬菜粉30-35份、辅料3-5份；所述辅料，由原料按以下重量份数制成，纤维素酶1-1.5份、苹果酸0.5-1份、蔗糖1-1.5份、阿拉伯胶0.5-1份。
实施例2
所述一种化血胆利肝护胆颗粒，原料按最佳重量份数，化血胆28份、鸡骨香20份、白叶火草18份、白芷15份、葛花14份、山梗菜10份、菊苣8份、青龙藤7份、刺瓜米草4份、蔬菜粉30份、辅料4份。
实施例3
所述一种化血胆利肝护胆颗粒，所述蔬菜粉的原料为凉瓜、油豆、莲藕、木耳、巴西蘑菇中一种或几种的组合。
所述蔬菜粉原料为凉瓜和油豆或凉瓜和莲藕、凉瓜和木耳、凉瓜和巴西蘑菇、油豆和莲藕、油豆和木耳、油豆和巴西蘑菇、莲藕和木耳、莲藕和巴西蘑菇、木耳和巴西蘑菇的组合。
所述蔬菜粉原料为凉瓜、油豆、莲藕或凉瓜、木耳、巴西蘑菇或油豆、木耳、巴西蘑菇的组合。
所述蔬菜粉原料为凉瓜、油豆、莲藕、木耳或油豆、莲藕、木耳、巴西蘑菇或凉瓜、油豆、木耳、巴西蘑菇的组合。
所述蔬菜粉的原料为凉瓜、油豆、莲藕、木耳、巴西蘑菇的组合。
实施例4
所述一种化血胆利肝护胆颗粒，所述辅料中原料按最佳重量份数，纤维素酶1.2份、苹果酸0.6份、蔗糖1.5份、阿拉伯胶0.8份。
实施例5
所述一种化血胆利肝护胆颗粒的制备方法，包括以下工序：
（1）原料预处理：
按重量份数，取优质的化血胆、鸡骨香、白叶火草、白芷、葛花、山梗菜、菊苣、青龙藤、刺瓜米草、蔬菜，洗净，备用；
（2）制备中药液：
按重量份数，取洗净的化血胆、鸡骨香、白叶火草、白芷、葛花、山梗菜、菊苣、青龙藤、刺瓜米草，混合，加入3-5倍饮用水，浸泡12-15小时，使用超声波法进行一次植物细胞破壁；破壁后，再加入纤维素酶，于70-80℃条件下，酶解20-25分钟，过滤，得酶解液；取酶解液，加热至100℃，加热10-15分钟，进行酶失活处理，得中药液；
（3）制备蔬菜粉：
按重量份数，取洗净的蔬菜，根据原料特性，切成条、丝、片状，放入热水中焯煮至熟透，冷却至室温，再置于烘干机内，经脱水干燥得干菜，再将干菜粉碎至200-240目的超微蔬菜粉；
（4）混合制粒：
按重量份数，取中药液、蔬菜粉，置于搅拌机内，再加入苹果酸、蔗糖、阿拉伯胶，混合均匀，得混合物；将混合物置于摇摆制粒机内制粒，得整粒；
（5）干燥：
取工序（4）中得到的整粒，高温干燥至水分含量为2%以下，得干粒；将干粒用振动筛筛选20-30目之间的颗粒，混合装袋，即得成品。
所述蔬菜粉、辅料中的原料，只是示例性说明，但不只局限于上述原料，相关技术人员可对其进行等同置换。
Claims (5)
1.一种化血胆利肝护胆颗粒，其特征在于：由原料按以下重量份数制成，化血胆25-30份、鸡骨香20-25份、白叶火草15-18份、白芷13-17份、葛花12-16份、山梗菜10-13份、菊苣8-10份、青龙藤5-8份、刺瓜米草3-5份、蔬菜粉30-35份、辅料3-5份；所述辅料，由原料按以下重量份数制成，纤维素酶1-1.5份、苹果酸0.5-1份、蔗糖1-1.5份、阿拉伯胶0.5-1份。
2.根据权利要求1所述一种化血胆利肝护胆颗粒，其特征在于：原料按最佳重量份数，化血胆28份、鸡骨香20份、白叶火草18份、白芷15份、葛花14份、山梗菜10份、菊苣8份、青龙藤7份、刺瓜米草4份、蔬菜粉30份、辅料4份。
3.根据权利要求1所述一种化血胆利肝护胆颗粒，其特征在于：所述蔬菜粉的原料为凉瓜、油豆、莲藕、木耳、巴西蘑菇中一种或几种的组合。
4.根据权利要求1所述一种化血胆利肝护胆颗粒，其特征在于：所述辅料中原料按最佳重量份数，纤维素酶1.2份、苹果酸0.6份、蔗糖1.5份、阿拉伯胶0.8份。
5.根据权利要求1-4任意一项所述一种化血胆利肝护胆颗粒的制备方法，其特征在于：包括以下工序，
（1）原料预处理：
按重量份数，取优质的化血胆、鸡骨香、白叶火草、白芷、葛花、山梗菜、菊苣、青龙藤、刺瓜米草、蔬菜，洗净，备用；
（2）制备中药液：
按重量份数，取洗净的化血胆、鸡骨香、白叶火草、白芷、葛花、山梗菜、菊苣、青龙藤、刺瓜米草，混合，加入3-5倍饮用水，浸泡12-15小时，使用超声波法进行一次植物细胞破壁；破壁后，再加入纤维素酶，于70-80℃条件下，酶解20-25分钟，过滤，得酶解液；取酶解液，加热至100℃，加热10-15分钟，进行酶失活处理，得中药液；
（3）制备蔬菜粉：
按重量份数，取洗净的蔬菜，根据原料特性，切成条、丝、片状，放入热水中焯煮至熟透，冷却至室温，再置于烘干机内，经脱水干燥得干菜，再将干菜粉碎至200-240目的超微蔬菜粉；
（4）混合制粒：
按重量份数，取中药液、蔬菜粉，置于搅拌机内，再加入苹果酸、蔗糖、阿拉伯胶，混合均匀，得混合物；将混合物置于摇摆制粒机内制粒，得整粒；
（5）干燥：
取工序（4）中得到的整粒，高温干燥至水分含量为2%以下，得干粒；将干粒用振动筛筛选20-30目之间的颗粒，混合装袋，即得成品。
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| CN103113975A (zh) * | 2013-02-05 | 2013-05-22 | 中国林业科学研究院林产化学工业研究所 | 一种物理破壁辅助水酶法提取茶油和糖萜素的方法 |
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