CN105377304B - 鹅膏毒肽衍生物 - Google Patents

鹅膏毒肽衍生物 Download PDF

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Publication number
CN105377304B
CN105377304B CN201480012523.6A CN201480012523A CN105377304B CN 105377304 B CN105377304 B CN 105377304B CN 201480012523 A CN201480012523 A CN 201480012523A CN 105377304 B CN105377304 B CN 105377304B
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amanita hemolysin
amanita
antibody
iii
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CN201480012523.6A
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Chinese (zh)
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CN105377304A (zh
Inventor
克里斯托夫·米勒
扬·安德尔
维尔纳·西蒙
克里斯蒂安·卢茨
托尔斯滕·赫克勒
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Heidelberg Pharma Research GmbH
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Heidelberg Pharma GmbH
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Priority claimed from PCT/EP2014/000614 external-priority patent/WO2014135282A1/en
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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201480012523.6A 2014-03-10 2014-03-10 鹅膏毒肽衍生物 Active CN105377304B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2014/000614 WO2014135282A1 (en) 2013-03-04 2014-03-10 Amatoxin derivatives

Publications (2)

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CN105377304A CN105377304A (zh) 2016-03-02
CN105377304B true CN105377304B (zh) 2018-05-15

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JP (1) JP6321687B2 (ja)
CN (1) CN105377304B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3222292A1 (en) * 2016-03-03 2017-09-27 Heidelberg Pharma GmbH Amanitin conjugates
JP2019522050A (ja) * 2016-06-17 2019-08-08 マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 細胞の枯渇のための組成物および方法
SG11201811290VA (en) * 2016-06-17 2019-01-30 Magenta Therapeutics Inc Compositions and methods for the depletion of cd117+cells
MX2019007604A (es) * 2016-12-23 2019-08-16 Heidelberg Pharma Res Gmbh Novedoso conjugado de amanitina.
AU2018317611B2 (en) * 2017-08-18 2022-03-10 Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. Non-natural amatoxin-type antibody conjugate
US20200368363A1 (en) * 2017-11-29 2020-11-26 Magenta Theerapeutics, Inc. Compositions and methods for the depletion of cd2+ cells
WO2019173780A2 (en) * 2018-03-08 2019-09-12 Magenta Therapeutics, Inc. Anti-cd252 antibodies, conjugates, and methods of use
CN109796537A (zh) * 2019-02-28 2019-05-24 中国农业大学 一种β-鹅膏毒肽人工抗原及其制备方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010115629A2 (en) * 2009-04-08 2010-10-14 Deutsches Krebsforschungszentrum Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy
WO2012041504A1 (en) * 2010-09-30 2012-04-05 Heidelberg Pharma Gmbh Amatoxin-conjugates with improved linkers
WO2012119787A1 (en) * 2011-03-10 2012-09-13 Heidelberg Pharma Gmbh Amatoxin-conjugates with improved linkages

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2649114A1 (en) * 2006-04-12 2007-10-25 Crosslink Genetics Corporation Compositions and methods for modulating gene expression
RU2011145038A (ru) * 2009-04-08 2013-05-20 Дойчес Кребсфоршунгсцентрум Несущие аматоксины мишень-связывающие молекулы для лечения рака

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010115629A2 (en) * 2009-04-08 2010-10-14 Deutsches Krebsforschungszentrum Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy
WO2012041504A1 (en) * 2010-09-30 2012-04-05 Heidelberg Pharma Gmbh Amatoxin-conjugates with improved linkers
WO2012119787A1 (en) * 2011-03-10 2012-09-13 Heidelberg Pharma Gmbh Amatoxin-conjugates with improved linkages

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Publication number Publication date
CN105377304A (zh) 2016-03-02
JP6321687B2 (ja) 2018-05-09
JP2016516010A (ja) 2016-06-02

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