CN105362697A - 一种祛斑养颜的白芷中药面膜及其制备方法 - Google Patents
一种祛斑养颜的白芷中药面膜及其制备方法 Download PDFInfo
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Abstract
本发明公开一种祛斑养颜的白芷中药面膜,包括以下重量份数的原料药:白芷10~50份,当归10~20份,玫瑰花10~20份,川芎10~20份,红花10~20份,合欢花10~20份,白僵蚕10~20份,益母草10~20份,红景天10~20份,辛夷10~20份,白芨10~20份,白蒺藜10~20份,薄荷10~20份,白蔹10~20份,防风10~20份,金盏花10~20份,白附子10~20份,积雪草10~20份,天花粉10~20份。中药面膜外用,除直接改善面部血液循环,用白芷、白僵蚕等中药活血化瘀,清热解毒。给予中药面膜直接作用于皮肤,使之吸收而达到外治的目的。本发明通过理气活血,调畅气血、疏通经络,使人体调整到持久,稳定的阴阳平衡、气血通畅的状态。
Description
技术领域
本发明涉及含有来源于植物、动物或矿物组份的医用配制品,特别涉及一种祛斑养颜的白芷中药面膜及其制备方法。
背景技术
祛斑面膜指的是将有淡斑祛斑功效的营养成份,加到由各种素材制作成的面膜中。而面膜将作为这种营养成份的载体,让营养成份被皮肤吸收后,来达到减淡和消除脸上色素斑的功效。
在不同的年龄阶段,人们脸上容易出现不同类型的斑。常见的色素斑包括有:太田痣、雀斑、晒斑、老年斑。色素斑是由很多种因素引起的:一是与遗传有关,父母亲某些色素性皮肤病遗传给下一代;二是内分泌失调引起色素沉着;三是不规律的生活习惯,长时间的精神压力造成皮肤色素沉着;四是外伤、痤疮等留下的疤痕,也可以留下色素沉着。维生素C为氧化剂,能抑制皮肤内多巴醌的氧化作用,使皮肤内的深色氧化型色素转化为还原型浅色素,抑制黑色素的形成。美白祛斑是女性的终身事业,无论你是20、30还是40,你对美白的要求也不会随着年龄的增长而减弱。色斑的困扰不是一天两天,要祛除色斑我们不能忽视祛斑面膜的作用,它能密集为皮肤注入淡斑元素,抑制黑色素的形成。本发明美白祛斑面膜能够给肌肤最天然的护理,安全又直接。美女们还能根据自己的肤质状态来选择不同的调配材料,美白祛斑效果更有效哦!纯天然素材,帮你收获嫩白肌肤,帮你节省成本,打造雪白肌肤。
黄褐斑、蝴蝶斑属皮肤科常见病,发病机制目前尚不清楚。现代医学认为可能与内分泌失调、遗传、药物与化妆品、某些慢性疾病、紫外线过度照射等多种因素有关。其中内分泌失调是首要发病因素。色素斑最初即可为多发性,倾向于融合形成大小不一、不规则的斑片,对称分布于曝光露出的面部。以颧部、前额、两颊最突出,有时呈蝶翼状,偶见于上唇部。边缘清楚或呈弥漫性,局部无炎症及鳞屑。无自觉症状,色素随季节、日晒、内分泌变化等因素可稍有变化,往往经久不退,一部分于分娩后或停服避孕药后可缓慢消退。
黄褐斑是一种发生于面部的色素代谢异常性皮肤病,表现为颜面部面积大小不等的对称性黄褐或淡黑色斑片,平摊于皮肤之上,抚之不碍手。祖国医学将本病称为“黧黑斑”、“肝斑”、“面尘”等。由于本病的发生既有明显的内分泌、神经系统或消化系统等功能失调的病因可循,又受到许多外界的理化因素如日晒、热幅射、外伤(搔抓、摩擦等)、接触光敏性药物或化合物、外用银制剂、汞制剂等的影响,因此一般主张内外治结合。
白芷(拉丁文名:Angelicadahurica(Fisch.exHoffm.)Benth.etHook.f.exFranch.etSav),多年生高大草本,高1-2.5米,根圆柱形,茎基部径2-5厘米,基生叶一回羽状分裂,复伞形花序顶生或侧生,果实长圆形至卵圆形。
以根入药,有祛病除湿、排脓生肌、活血止痛等功能。主治风寒感冒、头痛、鼻炎、牙痛。赤白带下、痛疖肿毒等症,亦可作香料。北方的一些省区有栽培,多自产自销,少数调省外。一般生于林下、林缘、溪旁、灌丛和山谷草地。
白芷辛,温。归经入肺、脾、胃经。功能主治祛风,燥湿,消肿,止痛。治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣。
《纲目》:白芷,色白味辛,行手阳明;性温气厚,行足阳明;芳香上达,入手太阴肺经。如头、目、眉、齿诸病,三经之风热也;如漏、带、痈疽诸病,三经之湿热也;风热者辛以散之,湿热者温以除之。为阳明主药,故又能治血病、胎病,而排脓生肌止痛。治鼻渊、鼻衄、齿痛、眉棱骨痛,大肠风秘,小便出血,妇人血风眩运,翻胃吐食;解砒毒,蛇伤,刀箭金疮。
《本草经疏》:白芷,味辛气温无毒,其香气烈,亦芳草也。入手足阳明、足太阴,走气分,亦走血分,升多于降,阳也。性善祛风,能蚀脓,故主妇人漏下赤白。辛以散之,温以和之,香气入脾,故主血闭阴肿,寒热,头风侵目泪出。辛香散结而入血止痛,故长肌肤。芬芳而辛,故能润泽。辛香温散,故疗风邪久泻,风能胜湿也。香入脾,所以止呕吐。疗两胁风痛,头眩目痒,祛风之效也。
《本草汇言》:白芷,上行头目,下抵肠胃,中达肢体,遍通肌肤以至毛窍,而利泄邪气。如头风头痛,目眩目昏;如四肢麻痛,脚弱痿痹;如疮溃糜烂,排脓长肉;如两目作障,痛痒赤涩;如女人血闭,阴肿漏带;如小儿痘疮,行浆作痒,白芷皆能治之。第性味辛散,如头痛、麻痹、眼目、漏带、痈疡诸症,不因于风湿寒邪,而因于阴虚气弱及阴虚火炽者,俱禁用之。
中医在蝴蝶斑、黄褐斑的病因病机中所说的风邪似可以从广义的角度理解,如现代医学认识的日晒、热幅射、接触光敏性药物或化合物、外用银制剂、汞制剂等,均可以归结为风邪。因此,针对风邪而治的外用药还可以结合现代药理学研究结果,配伍防紫外线、防辐射的药物。在配方中还应结合现代药理学的研究成果酌情添加上述药物以使治疗有据可循。另外,对于剥脱性的药物,如附子、乌梅等,由于其皮肤剥脱作用会造成皮肤破损,易造成皮肤的色素沉着从而加重症状,应当慎用。
有关蝴蝶斑、黄褐斑的治疗,西药主要是剥脱剂(如维甲酸、水杨酸)、糖皮质激素制剂、铅汞制剂、氧化剂或还原剂(如氢醌、双氧水),都有不同程度的副作用或引起某些并发症。
发明内容
本发明所要解决的技术问题在于,在不同的年龄阶段,人们脸上容易出现不同类型的斑。常见的色素斑包括有:太田痣、雀斑、晒斑、老年斑。色素斑是由很多种因素引起的:一是与遗传有关,父母亲某些色素性皮肤病遗传给下一代;二是内分泌失调引起色素沉着;三是不规律的生活习惯,长时间的精神压力造成皮肤色素沉着;四是外伤、痤疮等留下的疤痕,也可以留下色素沉着。维生素C为氧化剂,能抑制皮肤内多巴醌的氧化作用,使皮肤内的深色氧化型色素转化为还原型浅色素,抑制黑色素的形成。美白祛斑是女性的终身事业,内服外调有不同程度的副作用或引起某些并发症;而中药内服药物有一些疗效,但是在药物生产成本较高,而且制备周期较长,制备方法繁琐;外用药物针对性差,个体施药不能从根本上治疗黄褐斑、蝴蝶斑;并且还有一定的副作用。因此,寻找一种高效安全的治疗蝴蝶斑、黄褐斑的药物已成为人们的迫切需求。
中药面膜外用,除直接改善面部血液循环,用白芷、白僵蚕等中药活血化瘀,清热解毒。给予中药面膜直接作用于皮肤,使之吸收而达到外治的目的。现代医学研究显示:酪氨酸酶是黑素产生过程中重要的催化剂,抑制其活性则可以控制黑素的产生,白芨可抑制酪氨酸酶的作用及其参加的酶促反应;另外,根据中药药理作用,白芷有抗酪氨酸酶活性,阻止酪氨酸氧化形成色素从而有嫩肤抗皱之功效。加之离子喷雾、按摩等手法可促进血液循环、扩张毛细血管、加速药物的渗透和吸收,从而达到增白、祛斑的作用。
为解决这些技术难题,本发明提供了一种祛斑养颜的白芷中药面膜,其所述面膜中可以包括以下重量份数的原料药:白芷10~50份,当归10~20份,玫瑰花10~20份,川芎10~20份,红花10~20份,合欢花10~20份,白僵蚕10~20份,益母草10~20份,红景天10~20份,辛夷10~20份,白芨10~20份,白蒺藜10~20份,薄荷10~20份,白蔹10~20份,防风10~20份,金盏花10~20份,白附子10~20份,积雪草10~20份,天花粉10~20份。
所述祛斑养颜的白芷中药面膜,其所述面膜中还可以包括以下重量份数的原料药:白芷10~40份,当归10~15份,玫瑰花10~15份,川芎10~15份,红花10~15份,合欢花10~15份,白僵蚕10~15份,益母草10~15份,红景天10~15份,辛夷10~15份,白芨10~20份,白蒺藜10~20份,薄荷10~20份,白蔹10~20份,防风10~20份,金盏花10~20份,白附子10~20份,积雪草10~20份,天花粉10~20份。
所述祛斑养颜的白芷中药面膜,其所述面膜中也可以包括以下重量份数的原料药:白芷10~30份,当归10~20份,玫瑰花10~20份,川芎10~20份,红花10~20份,合欢花10~20份,白僵蚕10~20份,益母草10~20份,红景天10~20份,辛夷10~20份,白芨10~15份,白蒺藜10~15份,薄荷10~15份,白蔹10~15份,防风10~15份,金盏花10~15份,白附子10~15份,积雪草10~15份,天花粉10~15份。
为解决上述技术问题,本发明还提供一种祛斑养颜的白芷中药面膜的制备方法,其所述面膜的制备方法包括:
a、把白芷用渗漉法,用80%乙醇提取;作为组分1备用;
b、取红景天、辛夷、薄荷和白芨用水蒸气法蒸馏,得结晶,研磨成粉,作为组分2;
c、再将剩余原料药用乙醇加热提取2次,为组分3;
d、将上述三种组分,合并搅拌,调和蜂蜡制成面膜,紫外线杀菌。
所述步骤a中,可以将切碎的白芷置于有盖不锈钢桶内,加80%乙醇液,质量为粗粉的0.8-1倍,搅拌均匀,湿润密闭放置24小时以上,使充分膨胀;将渗漉筒底部滤板用纱布袋包裹铺平后再将湿润膨胀后的药物样品拌松弄散,然后用不锈钢勺盛粉,均匀的装入渗漉筒,装10-12厘米厚,用T型棒压匀,再按上述操作,一层一层的装入,适当加压,药粉填装不得超过渗漉筒的2/3高处;药粉面上盖不锈钢孔板压牢,打开渗漉筒下面的放料阀,并放一容器,然后缓缓加入80%乙醇液;待排出药粉粉粒之间的空气,并有乙醇流出约20L左右,关闭放料阀,盖上漉筒、浸渍24小时,然后开放料阀进行渗漉,控制渗漉速度一般为1000g药材每分钟流出2~3ml,滤液放入贮液缸内,并将排空时的乙醇液倒入贮液缸;将渗滤液合并静置,作为组分1。
所述步骤b中,可以按照所述份数将红景天、辛夷、薄荷和白芨用水蒸气法蒸馏,得到结晶物,过100-120目细筛,作为组分2备用。
所述步骤c中,可以将上述蒸馏提取的药渣与剩余原料药加占其质量10倍量的乙醇,加热提取,每次1-2小时,合并提取液,静置后去上清液,然后100-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.32的浸膏,然后放入减压浓缩罐内,减压回收乙醇,浓缩至药液浓度为0.1g生药/mL,抽滤至滤液的相对密度为20℃时1.06;上述滤液经体积为10L的大孔吸附树脂柱吸附后,用10倍树脂柱体积的去离子水或蒸馏水洗脱,再用5倍树脂柱体积的95%乙醇洗脱,收集乙醇洗脱液,去除溶剂,成组分3。
所述步骤d中,可以将上述步骤提取的三种组分混合,搅拌均匀,加热,调和基质,紫外线杀菌装瓶冷藏。
所述祛斑养颜的白芷中药面膜的制备方法,其所选基质可以为蜂蜡或蜂蜜的一种。
所述祛斑养颜的白芷中药面膜的使用方法,由于本发明面膜不含防腐剂,必须冷藏,每次临睡前洁面后,将面膜均匀涂抹于脸部,至其充分吸收后,洗去即可。
面膜剂使用时,每晚临睡前清洁面部后,涂抹至有蝴蝶斑、黄褐斑处,一个小时候清洗掉即可。
中药面膜外用,除直接改善面部血液循环,用白芷、白僵蚕等中药活血化瘀,清热解毒。给予中药面膜直接作用于皮肤,使之吸收而达到外治的目的。现代医学研究显示:酪氨酸酶是黑素产生过程中重要的催化剂,抑制其活性则可以控制黑素的产生,白芨可抑制酪氨酸酶的作用及其参加的酶促反应;另外,根据中药药理作用,白芷有抗酪氨酸酶活性,阻止酪氨酸氧化形成色素从而有嫩肤抗皱之功效。加之离子喷雾、按摩等手法可促进血液循环、扩张毛细血管、加速药物的渗透和吸收,从而达到增白、祛斑的作用。
本发明本着治病求本的治疗法则,从气、瘀论治,兼以补虚扶正。通过理气活血,调畅气血、疏通经络,兼以滋补肝肾,使人体调整到持久,稳定的阴阳平衡、气血通畅的状态。从而达到祛斑养颜、美化容貌的目的。本发明通过理气活血,调畅气血、疏通经络,兼以滋补肝肾,使人体调整到持久,稳定的阴阳平衡、气血通畅的状态。从而达到祛斑养颜、活血化瘀、美化容貌的目的。本发明活血行气,祛斑消痤。用于气滞血瘀所致的黄褐斑、痤疮。蝴蝶斑。外用化瘀,祛风消斑。
具体实施方式
黄褐斑:又称蝴蝶斑、肝斑,呈现淡褐色,呈片状,斑片大小不等,边界清晰,形状不规则,不高出皮肤,常见于面部,对称于两颊,主要原因跟内分泌、女性荷尔蒙失调有关。在中医学上也被称之为肝斑,亦称“黧黑斑”,发生于面部淡褐色或褐色斑,多发于中年妇女。由于人的年龄增大,组织细胞间的微细循环受淤阻,细胞溶解死亡,黑色素增多形成色斑沉着所造成的,是发生在颜面的色素沉着斑。长期口服避孕药、患有盆腔炎、子宫肌瘤等症的女性也易长黄褐斑。
雀斑:99%来自遗传,大约在5~6岁间形成,在蓝发的白种人相当常见,然而亚洲人也所在多有。发生的年龄在青春期前,阳光晒得到的部位产生大小约1至2nm的浅棕色斑点,其大小、数目及色素深度在夏季加重,在冬季转好。。
晒斑:受晒皮肤出现肉眼可见、边缘清晰的红斑、丘疹等皮疹红斑、水肿症状,颜色为淡红色、鲜红色或者深红色,呈现椭圆形突起或平滑,数天后最终成为碎碎的棕色斑块,容易出现在前臂外侧、手背、小腿前侧及脸部等暴露部位。
孕斑(妊娠斑):在怀孕时出现,但在产后便会退去;由于黑斑形成的时间与怀孕时的年纪很接近,因此有些人会在孕斑出现的同时也出现黑斑,因此有些人会误以为怀孕生产后所产生的是孕斑。
汞斑:有些人的皮肤产生了黑斑,而不懂如何的保护,道听途说用了一些可以变白的产品,但这些产品没经过化验是否含有汞的成份,它虽然可以暂时美白,残留的汞及毒素却会使皮肤受到更大的伤害,甚至会伤害到肾脏。有些不良的厂商会将汞加在美白霜里面,短时间漂白效果会很明显,然而若长期使用,汞元素会沈淀在皮肤里,会反黑而且更黑,也就是俗称的汞斑。
汗斑:汗斑是相当常见的疾病,尤其好发于夏天。在皮肤科门诊常有些病患,以为由汗水所引起的所有皮疹,都叫汗斑,其实这是不正确的。汗斑的确较容易发生在汗水郁积处,像是脖颈、前胸、后背,但是它是特指由一种类酵母菌样的霉菌感染皮肤所造成的皮疹。典型的汗斑会以雨滴状的白色或咖啡色斑点来表现。如果流汗或遇热时有时后患部会突然发红或发痒,为其特色。
蒙古斑:出生时在身上尤其是臀部、下背部有淡蓝色的斑痕,有如撞到「黑青、淤血」,通常四岁以前会完全消褪,不需要治疗。
田母斑:此种黑色素细胞增生的范围,从嘴角向上至额头的部位都可能连成一片深蓝灰色的斑,绝大多数是单侧,也有少数病例双侧都有,其特征为眼睛的巩膜(眼白)的部分也有深蓝色斑点。出生时可能很淡,会越来越多越深色。有些人是出生时并没有,孩提时代甚至青春期才慢慢产生。
黑斑:皮肤较薄、较干的人会比较明显,可能是疏于保养、防晒工作做不完整,而使黑色素容易浮到皮肤的表层造成,为中年女性最常见的美容问题(男性也会产生黑斑但很少见)。通常在两颊、额头、上唇部及下巴,产生一整片赭棕色的斑,因为颜色的关系又俗称肝斑。产生的原因和恶化的因素包括:怀孕、口服避孕药、某些药物(如抗癫痫药)及日晒。绝大多数的人一旦产生就很难自然消褪。调理方法,包括维他命A酸、杜鹃花酸、对苯二酚、果酸、左旋维他命C、曲酸等等,配合彻底的防晒措施,可以得到相当好的治疗效果。
老年斑:全称为″老年性色素斑″,医学上又被称为脂溢性角化。是指在老年人皮肤上出现的一种脂褐质色素斑块,属于一种良性表皮增生性肿瘤,一般多出现在面部、额头、背部、颈部胸前等,有时候也可能出现在上肢等部位。大部分是在50岁以后开始长,多见于高龄老人,人们又称其为″寿斑″。现代医学研究结果表明,这个雅号名实不符,它并非长寿的标志,专家们发现,随着人口平均年龄的增长,老年斑在老年人中并不普遍,仅占27%。
黄褐斑是一种发生于面部的色素代谢异常性皮肤病,表现为颜面部面积大小不等的对称性黄褐或淡黑色斑片,平摊于皮肤之上,抚之不碍手。本病男女均可发生,以女性较多。其病理机制复杂,内分泌失调、紫外线照射、药物与化妆品、精神因素等均可导致本病的发生。黄褐斑、蝴蝶斑与肝、肾有关而后天失调,脾失健运,气血不能上荣于面,亦生褐斑。总之,本病与肝、脾、肾三脏,尤其与肝脏关系密切。黄褐斑又名黧黑斑,表现为面黑、黧黑、面尘、面皯、肝斑、面生黑斑等症状,为一种多因性色素沉着病,影响患者容貌,给其造成严重的心理压力。但黄褐斑的发病原因和机理复杂,其中肝气郁滞、肾水(阳)不足和血瘀内阻为其最多见的证型,其次是脾土亏虚。
中医病因病机分析:在中医的经典文献中,对本病的病因病机有如下论述。《诸病源候论》说:“面黑者,或脏腑有痰饮,或皮肤受风邪,皆令气血不调,致生黑。五脏六腑十二经血,皆上于面,夫血之行,俱荣表里。人或痰饮渍藏,或腠理受风致血气不和,或涩或浊,不能荣于皮肤,故变生黑”。《医宗金鉴》曰:“由忧思抑郁,血弱不华,火燥结滞而生于面上,妇女多有之。”《外科大成》曰:“黧黑斑多生于女子之面,由血弱不华,火燥结成,疑事不决所致。”《外科正宗》曰:“黧黑斑者,水亏不能制火、血弱不能华肉,以致火燥结成斑黑,色枯不泽。”祖国医学认为,本病发生的内因与肝、脾、肾三脏以及气血运行的失常关系密切,因此内治在脏腑多从肝脾肾论治,在气血多从理气养血活血入手;本病发生的外因是因为“腠理受风致血气不和,或涩或浊,不能荣于皮肤”,或“血弱不华,火燥结成”,即由于血虚或皮肤受风邪或气血运行不畅所导致的经脉失养。因此,外治应从补血行血驱风的角度来组方。
中医气血理论认为,气血循环过程是人体一切组织器官进行工作的物质基础,气血以流畅平衡为贵,如果气血不流畅就会产生瘀血,瘀血阻于体内,将进一步导致气血循环的恶化,造成更严重的瘀塞,故中医以气血为纲,通过调气活血使之流畅平衡,可祛病强身、养血美容。皮肤斑点之根本在瘀,退斑必先祛瘀、祛瘀当须活血,活血更须补气、理气,气为血之帅,血随之而运行;血为气之守,气得之而静谧,气结则血凝,气虚则血脱,气迫则血走。气血和则俱和。而理气在肝,补气在肺肾,肺主皮毛。因气滞血瘀,影响到肺脾肝肾的气血运行功能,而致面部出现黄褐斑、雀斑等色斑,甚至出现头发脱落、斑秃。本发明主要根据传统中医学辨正施治的原理,集众医家所长,广采博收地区奇药妙方,提取精华;基于中医学对面部色斑的发病机理的认识及治疗原则,参考古今中医学药理研究成就,筛选补气活血、补气升阳、疏肝解郁、平肝潜阳、滋阴补肾、清热解毒、清热泻火的天然中药,扶正祛邪,通腑泄毒,活血散瘀,调节人体的新陈代谢机能,提高人体血液循环及肝脏解毒能力,并经长期诊疗病例的临床实践总结而成。
白芷(拉丁文名:Angelicadahurica(Fisch.exHoffm.)Benth.etHook.f.exFranch.etSav),多年生高大草本,高1-2.5米,根圆柱形,茎基部径2-5厘米,基生叶一回羽状分裂,复伞形花序顶生或侧生,果实长圆形至卵圆形。
以根入药,有祛病除湿、排脓生肌、活血止痛等功能。主治风寒感冒、头痛、鼻炎、牙痛。赤白带下、痛疖肿毒等症,亦可作香料。北方的一些省区有栽培,多自产自销,少数调省外。一般生于林下、林缘、溪旁、灌丛和山谷草地。
白芷辛,温。归经入肺、脾、胃经。功能主治祛风,燥湿,消肿,止痛。治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣。
《纲目》:白芷,色白味辛,行手阳明;性温气厚,行足阳明;芳香上达,入手太阴肺经。如头、目、眉、齿诸病,三经之风热也;如漏、带、痈疽诸病,三经之湿热也;风热者辛以散之,湿热者温以除之。为阳明主药,故又能治血病、胎病,而排脓生肌止痛。治鼻渊、鼻衄、齿痛、眉棱骨痛,大肠风秘,小便出血,妇人血风眩运,翻胃吐食;解砒毒,蛇伤,刀箭金疮。
《本草经疏》:白芷,味辛气温无毒,其香气烈,亦芳草也。入手足阳明、足太阴,走气分,亦走血分,升多于降,阳也。性善祛风,能蚀脓,故主妇人漏下赤白。辛以散之,温以和之,香气入脾,故主血闭阴肿,寒热,头风侵目泪出。辛香散结而入血止痛,故长肌肤。芬芳而辛,故能润泽。辛香温散,故疗风邪久泻,风能胜湿也。香入脾,所以止呕吐。疗两胁风痛,头眩目痒,祛风之效也。
《本草汇言》:白芷,上行头目,下抵肠胃,中达肢体,遍通肌肤以至毛窍,而利泄邪气。如头风头痛,目眩目昏;如四肢麻痛,脚弱痿痹;如疮溃糜烂,排脓长肉;如两目作障,痛痒赤涩;如女人血闭,阴肿漏带;如小儿痘疮,行浆作痒,白芷皆能治之。第性味辛散,如头痛、麻痹、眼目、漏带、痈疡诸症,不因于风湿寒邪,而因于阴虚气弱及阴虚火炽者,俱禁用之。
中药面膜外用,除直接改善面部血液循环,用白芷、白僵蚕等中药活血化瘀,清热解毒。给予中药面膜直接作用于皮肤,使之吸收而达到外治的目的。现代医学研究显示:酪氨酸酶是黑素产生过程中重要的催化剂,抑制其活性则可以控制黑素的产生,白芨可抑制酪氨酸酶的作用及其参加的酶促反应;另外,根据中药药理作用,白芷有抗酪氨酸酶活性,阻止酪氨酸氧化形成色素从而有嫩肤抗皱之功效。加之离子喷雾、按摩等手法可促进血液循环、扩张毛细血管、加速药物的渗透和吸收,从而达到增白、祛斑的作用。
黄芪以补虚为主,能补气固表,利尿托毒,排脓,敛疮生肌。用于气血不足、疮疡内陷、脓成不溃或久溃不敛者。黄芪具有很好的托毒生肌的功能,即久不愈合的脓肿化脓生肌。现代医学研究表明,黄芪内含而多种抗菌有效成分,而且能增强机体的免疫功能,因此还能用于预防某些传染病的发生。《本草逢原》载:“黄芪能补五脏诸虚,治脉弦自汗,泻阴火,去肺热,无汗则发,有汗则止。”是增进抵抗力和防御疾病的良药。
当归:其味甘而重,故专能补血,其气轻而辛,故又能行血,补中有动,行中有补,诚血中之气药,亦血中之圣药。大约佐之以补则补,故能养营养血,补气生精,安五脏,强形体,益神志,凡有形虚损之病,无所不宜。佐之以攻则通,故能祛痛通便,利筋骨,治拘挛、瘫痪、燥、涩等证。营虚而表不解者,佐以柴、葛、麻、桂等剂,大能散表卫热,而表不敛者,佐以大黄之类,又能固表。惟其气辛而动,故欲其静者当避之,性滑善行,大便不固者当避之。凡阴中火盛者,当归能动血,亦非所宜,阴中阳虚者,当归能养血,乃不可少。
川芎辛,温。归肝、胆、心包经。功能活血行气,祛风止痛。用于月经不调,经闭痛经,症瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛。川穹性温,是妇科常用药品,有活血顺气的作用,但也不能多用,尤其是身体有出血现象的人不适合服用,如女性经期。同时,川穹又是药膳中常用的药材之一,与乌鸡同食,可以养阴活血,是女性滋补佳品。
天竺葵,拉丁学名:Pelargoniumhortorum,具有止血,收缩血管,气喘,肝排毒,胆结石,肾排毒,肾结石,利尿,肌肉酸痛,油性皮肤,老化皮肤活化,疱疹,皮肤苍白,减肥,促进结疤,湿疹,灼伤晒伤,癣,月经不顺,乳房充血发炎,减轻忧郁不安,驱赶恶魔,补身,除臭,抗菌,杀菌,戒烟〔酒〕。天竺葵的主要功能在于调肤,天竺葵提取液中的有效成分与天然有机脂具有很强的亲和性,因此,天竺葵常与有机脂结合制成凝脂产品。一般的清洁用品在清洗过后,护肤的功能性成分大部分会被水冲洗流失,瑞士的科研人员在三高新鲜提取技术的基础上,通过添加择向活性酶等手段,使天竺葵的有效成分在与凝脂亲和的同时也与肌肤表皮层产生亲和性,这种亲和性超越了与水的亲和性,因此,在清洗的过程中,天竺葵的大部分有效成分仍能够被皮肤吸收,起到调肤的效果,天竺葵几乎适合各种皮肤状况,因为它能平衡皮脂分泌而使皮肤饱满。可能对湿疹、灼伤、带状疱疹、疱疹、癣及冻疮有益。对松垮、毛孔阻塞及油性皮肤也很好,由于天竺葵可以收缩毛孔,促进血液循环,使用后会让苍白的皮肤较为红润有活力,使皮肤亮泽细腻。
红景天,中药名。为景天科大花红景天的干燥根和根茎,秋季花茎凋枯后采挖,除去粗皮,洗净,晒干。味甘、苦,性平,归肺、心经。具有益气活血,通脉平喘之功。主要用于气虚血瘀,胸痹心痛,中风偏瘫,倦怠气喘。《中药大辞典》记载:红景天“性寒,味甘涩。活血止血,清肺止咳。治咳血,咯血,肺炎咳嗽。
益母草味辛苦、凉。活血、祛淤、调经、消水。治疗妇女月经不调,胎漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血、泻血,痈肿疮疡。益母草含益母草碱、延胡索酸等物质,有活血调经、降血压、利尿消肿等作用。
合欢花含有合欢甙,鞣质,解郁安神,理气开胃,活络止痛,用于心神不安、忧郁失眠。治郁结胸闷,失眠,健忘,风火眼,能安五脏,和心志,悦颜色,有较好的强身、镇静、安神、美容的作用,也是治疗神经衰弱的佳品。也具有清热解暑,养颜祛斑解酒等功效。《本草经》说:“合欢花能安五脏,和心志,悦颜色。”尤其对孕妇,有较好的强身、镇静、安神、美容的作用,也是治疗神经衰弱的佳品。
白芨性苦、甘、涩,微寒。归肺、肝、胃经。功能主治收敛止血,消肿生肌。用于咳血吐血,外伤出血,疮疡肿毒,皮肤皲裂;肺结核咳血,溃疡病出血。《神农本草经》:“主痈肿、恶疮、败疽,伤阴死肌,胃中邪气”;《本草纲目》:“气味(根)苦、平、无毒。
白僵蚕入肝、肺,胃经。祛风解痉,化痰散结。治中风失音,惊痫,头风,喉风。喉痹,瘰疬结核。风疮瘾疹,丹毒,乳腺炎。《本经》:主小儿惊痫夜啼,去三虫,灭黑黜,男子阴疡病。《别录》:女子崩中赤白,产后佘痛,灭诸疮瘢痕。未之,封疔肿,根当自出。《药性论》:治口噤,发汗,主妇人崩中下血不止。
辛夷性温,味辛微苦。归经归肺、胃经。散风寒,通鼻窍。用于风寒头痛,鼻塞,鼻渊,鼻流浊涕。《本经》:主五脏身体寒热,风头脑痛,面酐。《别录》:温中解肌,利九窍,通鼻塞、涕出,治面肿引齿痛,眩冒、身几几如在车船之上者。生须发,去白虫。《药性论》:能治面生酐。面脂用,主光华。
白蔹归经:心经;肺经;肝经;脾经。功能:清热解毒;散结止痛;生肌敛疮。主治:疮疡肿毒,瘰疬,烫伤,湿疮,温疟,惊痫,血痢,肠风,痔漏,白带,跌打损伤,外伤出血。白蔹为葡萄科植物白蔹的根,每年春、秋季采挖,除去茎及细须根,洗净后多纵切成两瓣、四瓣或斜片,晒干即可入药。其性凉,味苦甘辛,具有清热、解毒、散结、生肌、止痛的功效,用于治疗痈肿、疔疮、瘰疬、烫伤、温疟、惊痫、血痢、肠风、痔漏等症
月季花,中药名。为蔷薇科植物月季RosachinensisJacq.的干燥花。全年均可采收,花微开时采摘,阴干或低温干燥。均为栽培。具有活血调经,疏肝解郁之功效。常用于气滞血瘀,月经不调,痛经,闭经,胸胁胀痛。
独活,中药名。为伞形科植物重齿毛当归的干燥根。主产于四川、湖北、安徽等地。春初或秋末采挖,除去须根及泥沙,炕至半干,堆置2~3天,发软后再炕至全干。切片,生用。《本草正》:“专理下焦风湿,两足痛痹,湿痒拘挛。”现代研究,独活有抗炎、镇痛及镇静作用;对血小板聚集有抑制作用;并有降压作用,但不持久;所含香柑内酯、花椒毒素等有光敏及抗肿瘤作用。
金盏花,拉丁名(Calendulaofficinalis),又名金盏菊、常春花。金盏菊富含多种维生素,尤其是维生素A和维生素C,可预防色素沉淀、增进皮肤光泽与弹性、减缓衰老、避免肌肤松弛生皱。也可预防文明病,如血管病变及癌症,更能理气止咳、健胃、化痰、预防哮喘及支气管炎。几乎各部位都可以食用;其花瓣有美容之功能,花含类胡萝卜素、番茄烃、蝴蝶梅黄素、玉红黄质、挥发油、树脂、黏液质、苹果酸等。根含苦味质,山金东二醇;种子含甘油酯、蜡醇和生物碱。放入洗发精里可以使得头发颜色变淡。薄荷,土名叫“银丹草”,为唇形科植物,即同属其他干燥全草,多生于山野湿地河旁,根茎横生地下,是一种有特种经济价值的芳香作物。全株青气芳香。叶对生,花小淡紫色,唇形,花后结暗紫棕色的小粒果。薄荷是中华常用中药之一。它是辛凉性发汗解热药,治流行性感冒、头疼、目赤、身热、咽喉、牙床肿痛等症。处用可治神经痛、皮肤瘙痒、皮疹和湿疹等。薄荷是中国常用中药,幼嫩茎尖可作菜食,全草又可入药,治感冒发热喉痛,头痛,目赤痛,肌肉疼痛,皮肤风疹搔痒,麻疹不透等症,此外对痈、疽、疥、癣、漆疮亦有效。薄荷含有薄荷醇,该物质可清新口气并具有多种药性,可缓解腹痛、胆囊问题如痉挛,还具有防腐杀菌、利尿、化痰、健胃和助消化等功效。大量食用薄荷可导致失眠,但小剂量食用却有助于睡眠。
积雪草具有清热解毒,利湿消肿、滋补、消炎、镇定的作用。能刺激深层皮肤细胞更替。积雪草可以紧致表皮与真皮连接部分,能使皮肤变柔软,有助于解决皮肤松弛现象,使皮肤光滑有弹性;促进真皮层中胶原蛋白形成,使纤维蛋白再生,重新连接起来,使肌肤达到紧致光滑的效果。还可帮助受损的组织愈合及紧实肌肤。既能促进表皮与真皮之间的密切连接,又能抑制脂肪细胞的增加,防止皮肤水肿、出现肥胖。积雪草适用于各种肤质,其幼芽的水提取物具有抗菌消炎的作用,其属双子叶植物伞形科,能消肿解毒祛脓疮
天花粉,中药名。《本草正义》:药肆之所谓天花粉者,即以萎根切片用之,有粉之名,无粉之实。天花粉为葫芦科植物栝蒌的根,是一种中药,为清热泻火类药物,其具体功效是清热泻火,生津止渴,排脓消肿。主治:治热病口渴、消渴、黄疸、肺燥咳血、痈肿、痔痿。对于治疗糖尿病,常用它与滋阴药配合使用,以达到标本兼治的作用。
玫瑰花:《本草正文》中道:“玫瑰花,清而不浊,和而不猛,柔肝醒胃,疏气活血,宣通窒滞而绝无辛温刚燥之弊,断推气分药之中,最有捷效而最驯良,芳香诸品,殆无其匹”玫瑰花中含有300多种化学成份,如芳香的醇、醛、脂肪酸、酚和含香精的油和脂,常食玫瑰制品中以柔肝醒胃,舒气活血,美容养颜,令人神爽。玫瑰初开的花朵及根可入药,有理气、活血、收敛等作用、主治月经不调,跌打损伤、肝气胃痛,乳臃肿痛等症。玫瑰果的果肉,可制成果酱,具有特殊风味,果实含有丰富的维生素C及维生素P,可预防急、慢性传染病、冠心病、肝病和阻止产生致癌物质等。用玫瑰花瓣以蒸馏法提炼而得的玫瑰精油(称玫瑰露),可活化男性荷尔蒙及精子。玫瑰露还可以改善皮肤质地,促进血液循环及新陈代谢。
白附子,中药名。为天南星科植物独角莲TyphoniumgiganteumEngl.的干燥块茎。秋季采挖,除去须根和外皮,晒干。河北、山东、山西、陕西、甘肃、宁夏、四川、贵州、西藏等地都有野生。东北各省、山东、江苏、河南、湖北有栽培。具有祛风痰,定惊搐,解毒散结,止痛的功效。用于中风痰壅,口眼唱斜,语言謇涩,惊风癫痫,破伤风,痰厥头痛,偏正头痛,瘰疬痰核,毒蛇咬伤。
白蒺藜苦、辛,平,入肝经。功用效果:平肝解郁,祛风明目。用于肝阳眩晕头痛,肝郁胁痛,风热头痛,目赤肿痛,皮肤瘙痒等症。含挥发油、皂甙,脂肪油、硝酸盐类、树脂、黄酮类化合物及微量生物碱等。
防风,中药名。别名铜芸、回云、回草、百枝、百种。是一种药草的名字,多年生草本植物,其喜凉爽气候,耐寒,耐干旱,主产于河北、黑龙江、四川、内蒙古等地。防风的根可生用。味辛、甘,性微温。有祛风解表,胜湿止痛,止痉的功效。《本草纲目》:“三十六般风,去上焦风邪,头目滞气,经络留湿,一身骨节痛。除风去湿仙药。”《药类法象》:“治风通用。泻肺实,散头目中滞气,除上焦邪。”
具体实施例1
a、把白芷用渗漉法,用80%乙醇提取;作为组分1备用;
b、取红景天、辛夷、薄荷和白芨用水蒸气法蒸馏,得结晶,研磨成粉,作为组分2;
c、再将剩余原料药当归,玫瑰花,川芎,红花,合欢花,白僵蚕,益母草,白蒺藜,白蔹,防风,金盏花,白附子,积雪草,天花粉,用乙醇加热提取2次,为组分3;
d、将上述三种组分,合并搅拌,调和蜂蜡制成面膜,紫外线杀菌。
具体实施例2
将切碎的白芷3000g置于有盖不锈钢桶内,加80%乙醇液,质量为粗粉的0.8-1倍,搅拌均匀,湿润密闭放置24小时以上,使充分膨胀;将渗漉筒底部滤板用纱布袋包裹铺平后再将湿润膨胀后的药物样品拌松弄散,然后用不锈钢勺盛粉,均匀的装入渗漉筒,装10-12厘米厚,用T型棒压匀,再按上述操作,一层一层的装入,适当加压,药粉填装不得超过渗漉筒的2/3高处;药粉面上盖不锈钢孔板压牢,打开渗漉筒下面的放料阀,并放一容器,然后缓缓加入80%乙醇液;待排出药粉粉粒之间的空气,并有乙醇流出约20L左右,关闭放料阀,盖上漉筒、浸渍24小时,然后开放料阀进行渗漉,控制渗漉速度一般为1000g药材每分钟流出2~3ml,滤液放入贮液缸内,并将排空时的乙醇液倒入贮液缸;将渗滤液合并静置,作为组分1。
再将红景天1000g、辛夷1000g、薄荷1000g和白芨1000g用水蒸气法蒸馏,得到结晶物,过100-120目细筛,作为组分2备用。
再将上述蒸馏提取的药渣与剩余原料药当归1000g,玫瑰花1000g,川芎1000g,红花1000g,合欢花1000g,白僵蚕1000g,益母草1000g,白蒺藜1000g,白蔹1000g,防风1000g,金盏花1000g,白附子1000g,积雪草1000g,天花粉1000g加占其质量10倍量的乙醇,加热提取,每次1-2小时,合并提取液,静置后去上清液,然后100-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.32的浸膏,然后放入减压浓缩罐内,减压回收乙醇,浓缩至药液浓度为0.1g生药/mL,抽滤至滤液的相对密度为20℃时1.06;上述滤液经体积为10L的大孔吸附树脂柱吸附后,用10倍树脂柱体积的去离子水或蒸馏水洗脱,再用5倍树脂柱体积的95%乙醇洗脱,收集乙醇洗脱液,去除溶剂,成组分3。
然后将上述步骤提取的三种组分混合,搅拌均匀,加热,调和基质,紫外线杀菌装瓶冷藏。
具体实施例3
本发明的制备:将切碎的白芷3000g置于有盖不锈钢桶内,加80%乙醇液浸泡加热提取2次,每次1-2小时,去上清液,合并提取液,80-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.36的浸膏,加热浓缩,30分钟~45分钟,将浓缩液静置成浸膏状,药糊继续加热浓缩至浸膏状,静置备用,再将红景天1000g、辛夷1000g、薄荷1000g和白芨1000g蒸馏称粉末,取原料药当归1000g,玫瑰花1000g,川芎1000g,红花1000g,合欢花1000g,白僵蚕1000g,益母草1000g,白蒺藜1000g,白蔹1000g,防风1000g,金盏花1000g,白附子1000g,积雪草1000g,天花粉1000g取原料药加入5-10倍量的乙醇中浸泡1-2小时,加热提取2次,每次1-2小时,合并提取液,静置后去上清液,然后100-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.36的浸膏,静置备用,然后将上述步骤提取的三种组分混合,搅拌均匀,加热,调和基质,紫外线杀菌装瓶冷藏。
药理学毒性试验
毒理学试验:
试验例1:本发明急性毒性试验
一、试验材料:
动物:昆明种小鼠,体重21-24g,雌雄各半,山东大学生物试验室育种。药物:本发明美容霜。
二、方法:
1、LD50计算:采用改良寇氏法,将小鼠随机分成5组,每组10只,雌雄各半,将洗液剂溶解,配成最大浓度,按小鼠最大允许容量给药,所给剂量按生药量依次为18,14.4,11.5,9.2,7.4(g.kg-1),在动物禁食(不禁水)18小时后,一日内分两次给药(间隔半小时),每次0.5ml,观察动物死亡情况。
2、最大耐受剂量测定(MTD值):取小鼠20只,雌雄各10只。将片剂加蒸馏水溶解,配成最高浓度,按动物的最大耐受量,以注射灌喂器能抽动为准。在动物禁食(不禁水)18小时后,一日内分两次给药(间隔半小时),每次0.5ml(每ml含生药0.36g),总药量为18g生药/kg.d,相当临床成人50Kg体重用量的300倍。给药后连续观察7天。
三、试验结果:
在LD50计算中当用最大允许浓度和最大允许容量给予小鼠时(18g/Kg.d),未见小鼠死亡,即未测出LD50,只可求最大耐受剂量,在7天观察期中,动物其食欲、活动、毛色、精神状态等皆正常,发育正常,未见有死亡。即选用相当于临床剂量的300倍药量,并无不良反应发生,表明急性毒性极小,MTD>18g/Kg.d。
试验例2:本发明急性皮肤刺激试验报告
1、实验目的:检测本发明对实验动物皮肤的刺激/腐蚀作用和强度
2、材料和方法:
2.1.受试物名称:本发明美容霜(实施例方法2制得)
2.2.实验动物:壹级大耳白种家兔,10只,雌性,体重2.1-2.3kg;由青岛大学医学院生物系实验动物中心提供;
2.3.试验方法:
选用皮肤完好的健康家兔10只,于试验前24小时将其背部脊柱两侧被毛剪掉,去毛面积左、右各约4cm×4cm。试验时取受试物0.2ml涂于2.5cm×2.5cm的二层纱布上,敷贴于一侧去毛皮肤表面,油纸覆盖,胶布固定。另一侧皮肤作为空白对照。封闭4小时后,去除覆盖物,并用温水清洗去残留受试物,于去除受试物后的1、24和48小时观察涂抹部位皮肤反应,并评分。
3、实验结果:实验动物皮肤未出现任何红斑,红肿,发炎现象。
4、小结:根据《消毒技术规范》(1999)中皮肤刺激反应评分标准判定,本发明软膏剂对动物皮肤刺激强度属无刺激性。
实施例3:阴道粘膜刺激试验结果
1.试验方法:
实验动物检疫3天后,选用18只上述健康家兔,随机分为三组,每组各6只,分别为:空白对照、赋形剂对照、本发明眼霜。分别用适当大小的灭菌棉条浸以灭菌生理盐水和受试物置于赋形剂对照组和受试物组动物阴道内,与阴道粘膜接触6小时,24小时后处死动物。取出局部阴道组织,观察病变情况。
2、试验结果:阴道粘膜刺激试验结果
实施例4:皮肤过敏试验结果
用本发明美容霜,进行诱导和激发接触试验,在24小时和48小时后观察试验小鼠,均不见皮肤有红斑及水肿等现象,与阴性对照组无差异。结果表明,该膏剂对皮肤反应强度近于零,即无皮肤变态反应。
实施例5:长期毒性实验资料
1、实验方法
将豚鼠随机份成4组,每组15只。在豚鼠背部脊柱两侧将脱毛剂均匀涂上,使其脱毛范围约40平方厘米。洗净脱毛剂,观察24小时后每组豚鼠分别涂本发明眼霜0.2、0.4和0.8ml,分别含生药92、184和368mg,另一组涂溶媒0.8ml每日二次,连续30天,观察豚鼠的一般情况,实验结束后处死动物进行血液学、血液生化及病理学检查。
2、结果
上述三组用药豚鼠躯干去毛区,未见局部皮肤有水肿、充血、红斑、出血点及溃疡。用药组与对照组动物毛发色泽、摄食、四肢活动等对照组无明显差异,血液生化检查,用药组与对照组均在正常范围。病理组织学检查,实验各组心、肝、肾及局部皮肤均未见明显病变。提示,本发明中药面霜长期用药对局部皮肤及全身重要脏器均未见明显的毒性作用。
药理学实验
1材料
1.1动物:健康3月龄纯系昆明种雌性小鼠60只,体重25~35g,山东大学实验动物学部提供。动物饲养条件:每组小鼠按组别分笼饲养。在自然条件相同的情况下,常规饲食饮水,保持自然光照,无不良因素影响,饲养1周适应实验环境后开始进行实验,
1.2实验药品:本发明面膜,按实施例3方法制备,浓度:0.12mg/ml,本院药剂科生产。3%氢醌霜:武汉市中医医院药剂科生产,批号20050905。黄体酮注射液:浙江仙琚制药股份有限公司,批号:20050115。
1.3试剂:硫化钠(NaS):海凌峰化学试剂有限公可,批号:20020118,临用前配成10%水溶液。超氧化物歧化酶(SOD)、丙二醛(MDA)试剂盒:南京建成生物工程研究所,批号:20059116。
1.4主要仪器:DY89-II型电动玻璃匀浆机:宁波新兰生物科技股份有限公司。系统生物显微镜:OLYMPUS;BX50F4北航病理图像分析系统。
2实验方法
2.1模型制作:参照黄褐斑实验动物模型复制方法。小鼠2.5%戊巴比妥钠麻醉后,以0.4%的黄体酮注射液按0.02g/kg剂量小鼠后肢肌肉注射,每周6次,连续4周。正常组按0.02g/kg肌肉注射灭菌注射用水。
2.2动物分组及给药:取健康雌性小鼠60只,3个剂量组,随机分为6组,每组10只。正常组、模型组、本发明胶囊剂3个剂量组(0.15、0.3、0.6mg/ml)、3%氢醌阳性对照组(0.6mg/ml)。本发明3个剂量治疗组分别在小鼠造模当日用药,每日2次,每周6次,连续用药30天。正常组和模型组于相应时间给予蒸馏水;3%氢醌阳性药对照组于造模当日开始局部用药,时间和疗程同祛斑养颜口服液治疗组。
2.3观察指标及检测:用药30天后,颈椎脱臼处死小鼠,背部去毛,迅速取肝组织及涂药部位的皮肤组织各2块,其中一块用冰冷的生理盐水冲洗,除去血液,滤纸吸干,切取肝脏及皮肤各0.5g,分别放入2.0ml预冷生理盐水的烧杯中,剪碎组织,再倒入试管中,以高速分散器10r/min匀浆两次,每次10秒;再以3500r/min转速离心15分钟,取上清液。采用黄嘌呤氧化酶法,按试剂盒检测说明书方法测定SOD;采用硫代巴比妥酸法,按试剂盒检测说明书方法测定MDA值。同时,分离小鼠背部皮肤,取去毛的皮肤组织一块(2cm*1cm左右),10%多聚甲醛固定,常规石蜡包埋,切片,HE染色,常规组织病理检测,光镜观察,计数上皮增生、真皮血管数及真皮炎细胞数;免疫组化染色,观察黑色素细胞染色和数目(阳性细胞:无,计0分;<15%,计0.5分,<30%,计1分;>30%计2分)。
2.4统计学方法:计量资料采用组间比较t检验;分层计算资料采用秩和检验进行统计处理。
3结果
3.1各组小鼠皮肤、肝组织MDA、SOD含量的测定见表1。
表1各组小鼠皮肤及肝组织MDA、SOD含量的测定(-x±s)
与模型组比较*P<0.05,**P<0.01;与阳性组比较#**P<0.05
3.2各组小鼠皮肤病理组织形态学及免疫组织化学观察病理形态学观察可见:正常组小鼠表皮的上皮层细胞排列整齐,无增生,真皮层内未见小血管扩张,炎性细胞少见。模型组小鼠表皮的上皮层细胞增生明显,核大且排列紊乱,真皮层内可见小血管扩张,炎性细胞多见。大、中剂量组及阳性对照组小鼠表皮的上皮层细胞增生有所减轻,排列紊乱减轻,真皮层内小血管扩张减轻,炎性细胞少见。结果见表2。
免疫组织化学的病理形态学观察可见:正常组小鼠上皮层内可见少许黑色素细胞,胞浆着色棕褐色。模型组小鼠上皮层内可见大量黑色素细胞,胞浆着色深褐色,且阳性细胞数>30%。大、中剂量组及阳性对照组小鼠上皮层内可见黑色素细胞,胞浆着色深褐色,阳性细胞数减少,见表2。
表2各组小鼠皮肤组织病理形态学及黑色素细胞观察结果(n)
秩和检验;与模型组比较*P<0.05,**P<0.01
4、外用药剂的微循环实验方法:
4.1材料与方法:取50只小鼠,随机分成5组,每组10只(雌雄各半),对照组每鼠右耳涂生理盐水少许;阳性对照组每鼠右耳给予市售丝白祛斑软膏(金陵药业生产),受试组分为本发明面膜剂量组400mg/kg/h、本发明面膜600mg/kg/h,本发明面膜高剂量800mg/kg/h。15min后腹腔注射0.1%戊巴比妥钠0.1ml/10g麻醉动物,随后尾静脉注射0.1%肾上腺素0.1mL/10g,立即观察小鼠右耳微动静脉口径(μm)及0.2mm2毛细血管网点数.t检验处理实验数据.
4.2结果与讨论
4.2.1.对微循环的影响
与对照组相比,受试组1对小鼠毛细血管开放数有明显增多(P<0.01);受试组2对微静脉口径和毛细血管开放数有显著增加(P<0.01);受试组3对小鼠微动、静脉口径及毛细血管开放数皆有增加(P<0.01);说明受试药能改善微循环,有活血化瘀作用(表1)。
表3、本发明外用膏剂对小鼠微动、静脉口径及毛细血管开放数的影响
4讨论
黄褐斑中医称为“肝斑”,属祖国医学“黎黑斑”或“面尘”范畴。一般认为本病发生与肝、脾、肾三脏关系密切。
黄褐斑、肝斑是一种常见于面部的色素代谢障碍性皮肤疾病,好发于中年女性,其病因及发病机理尚未完全阐明。一般认为黄褐斑的发病与内分泌失调,紫外线照射,遗传因素有关。但近年的研究认为,黄褐斑、肝斑的发生还与氧自由基变化有关。在正常生理情况下,自由基不断产生,但也不断被消除,使之处于一种动态平衡。而黄褐斑、肝斑患者过氧化脂质(LPO)或自由基水平增高时,或是体内抗氧化酶如超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽(CSH)等下降,不能及时清除过氧化脂质等氧化产物,使LPO在体内堆积。从而加速酪氨酸系列氧化反应。致黑色素细胞产生黑色素增多;同时LPO极不稳定其产物丙二醛(MDA)可导致蛋白质分子发生交联,形成荧光发色团-色素。
由此提示本发明可清除氧自由基并减少自由基产生;病理组织学观察显示其能明显改善组织细胞的病理改变,减轻上皮细胞增生,减轻真皮层小血管扩张,减少炎细胞数目;免疫组化检测显示其可明显减少上皮层内黑色素阳性细胞数及光密度。表明本发明具有祛斑美白作用。
中药面膜外用,除直接改善面部血液循环,用白芷、白僵蚕等中药活血化瘀,清热解毒。给予中药面膜直接作用于皮肤,使之吸收而达到外治的目的。现代医学研究显示:酪氨酸酶是黑素产生过程中重要的催化剂,抑制其活性则可以控制黑素的产生,白芨可抑制酪氨酸酶的作用及其参加的酶促反应;另外,根据中药药理作用,白芷有抗酪氨酸酶活性,阻止酪氨酸氧化形成色素从而有嫩肤抗皱之功效。加之离子喷雾、按摩等手法可促进血液循环、扩张毛细血管、加速药物的渗透和吸收,从而达到增白、祛斑的作用。
Claims (10)
1.一种祛斑养颜的白芷中药面膜,其特征在于,所述面膜中包括以下重量份数的原料药:白芷10~50份,当归10~20份,玫瑰花10~20份,川芎10~20份,红花10~20份,合欢花10~20份,白僵蚕10~20份,益母草10~20份,红景天10~20份,辛夷10~20份,白芨10~20份,白蒺藜10~20份,薄荷10~20份,白蔹10~20份,防风10~20份,金盏花10~20份,白附子10~20份,积雪草10~20份,天花粉10~20份。
2.根据权利要求1所述祛斑养颜的白芷中药面膜,其特征在于,所述面膜中包括以下重量份数的原料药:白芷10~40份,当归10~15份,玫瑰花10~15份,川芎10~15份,红花10~15份,合欢花10~15份,白僵蚕10~15份,益母草10~15份,红景天10~15份,辛夷10~15份,白芨10~20份,白蒺藜10~20份,薄荷10~20份,白蔹10~20份,防风10~20份,金盏花10~20份,白附子10~20份,积雪草10~20份,天花粉10~20份。
3.根据权利要求1所述祛斑养颜的白芷中药面膜,其特征在于,所述面膜中包括以下重量份数的原料药:白芷10~30份,当归10~20份,玫瑰花10~20份,川芎10~20份,红花10~20份,合欢花10~20份,白僵蚕10~20份,益母草10~20份,红景天10~20份,辛夷10~20份,白芨10~15份,白蒺藜10~15份,薄荷10~15份,白蔹10~15份,防风10~15份,金盏花10~15份,白附子10~15份,积雪草10~15份,天花粉10~15份。
4.一种如权利要求1~3中任一项所述祛斑养颜的白芷中药面膜的制备方法,其特征在于,所述面膜的制备方法包括:
a、把白芷用渗漉法,用80%乙醇提取;作为组分1备用;
b、取红景天、辛夷、薄荷和白芨用水蒸气法蒸馏,得结晶,研磨成粉,作为组分2;
c、再将剩余原料药用乙醇加热提取2次,为组分3;
d、将上述三种组分,合并搅拌,调和蜂蜡制成面膜,紫外线杀菌。
5.根据权利要求4所述祛斑养颜的白芷中药面膜的制备方法,其特征在于,所述步骤a中,将切碎的白芷置于有盖不锈钢桶内,加80%乙醇液,质量为粗粉的0.8-1倍,搅拌均匀,湿润密闭放置24小时以上,使充分膨胀;将渗漉筒底部滤板用纱布袋包裹铺平后再将湿润膨胀后的药物样品拌松弄散,然后用不锈钢勺盛粉,均匀的装入渗漉筒,装10-12厘米厚,用T型棒压匀,再按上述操作,一层一层的装入,适当加压,药粉填装不得超过渗漉筒的2/3高处;药粉面上盖不锈钢孔板压牢,打开渗漉筒下面的放料阀,并放一容器,然后缓缓加入80%乙醇液;待排出药粉粉粒之间的空气,并有乙醇流出约20L左右,关闭放料阀,盖上漉筒、浸渍24小时,然后开放料阀进行渗漉,控制渗漉速度一般为1000g药材每分钟流出2~3ml,滤液放入贮液缸内,并将排空时的乙醇液倒入贮液缸;将渗滤液合并静置,作为组分1。
6.根据权利要求4所述祛斑养颜的白芷中药面膜的制备方法,其特征在于,所述步骤b中,按照所述份数将红景天、辛夷、薄荷和白芨用水蒸气法蒸馏,得到结晶物,过100-120目细筛,作为组分2备用。
7.根据权利要求4所述祛斑养颜的白芷中药面膜的制备方法,其特征在于,所述步骤c中,将上述蒸馏提取的药渣与剩余原料药加占其质量10倍量的乙醇,加热提取,每次1-2小时,合并提取液,静置后去上清液,然后100-120目滤过,再经截流分子量为5000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.32的浸膏,然后放入减压浓缩罐内,减压回收乙醇,浓缩至药液浓度为0.1g生药/mL,抽滤至滤液的相对密度为20℃时1.06;上述滤液经体积为10L的大孔吸附树脂柱吸附后,用10倍树脂柱体积的去离子水或蒸馏水洗脱,再用5倍树脂柱体积的95%乙醇洗脱,收集乙醇洗脱液,去除溶剂,成组分3。
8.根据权利要求4所述祛斑养颜的白芷中药面膜的制备方法,其特征在于,所述步骤d中,将上述步骤提取的三种组分混合,搅拌均匀,加热,调和基质,紫外线杀菌装瓶冷藏。
9.根据权利要求8所述祛斑养颜的白芷中药面膜的制备方法,其特征在于,所选基质为蜂蜡或蜂蜜的一种。
10.根据权利要求1~9中任一项所述祛斑养颜的白芷中药面膜的使用方法,其特征在于,本发明面膜不含防腐剂,必须冷藏,每次临睡前洁面后,将面膜均匀涂抹于脸部,至其充分吸收后,洗去即可。
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