CN105327045A - Lipid-lowering traditional Chinese medicine for treating NAFLD (non-alcoholic fatty liver diseases) and treatment method - Google Patents
Lipid-lowering traditional Chinese medicine for treating NAFLD (non-alcoholic fatty liver diseases) and treatment method Download PDFInfo
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- CN105327045A CN105327045A CN201510796706.8A CN201510796706A CN105327045A CN 105327045 A CN105327045 A CN 105327045A CN 201510796706 A CN201510796706 A CN 201510796706A CN 105327045 A CN105327045 A CN 105327045A
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Abstract
The invention provides a lipid-lowering traditional Chinese medicine for treating NAFLD (non-alcoholic fatty liver diseases) and a treatment method. The lipid-lowering traditional Chinese medicine comprises components by weight as follows: 25-30 g of poria cocos, 25-30 g of largehead atractylodes rhizome, 8-15 g of oriental waterplantain rhizome, 10-15 g of Chinese angelica, 20-30 g of danshen roots, 15-30 g of hawthorn fruits, 6-12 g of hiraute shiny bugleweed herb, 4-8 parts of scorpion, 7-12 g of cicada slough, 8-15 g of leeches, 10-20 g of turtle shells (firstly processed) and 20-30 g of membranous milkvetch roots. One dosage of the lipid-lowering traditional Chinese medicine is decocted once every day and taken orally in the morning and at night; cowherb seeds are adopted for pressing auricular acupoints, the acupoints include Shenmen, the stomach, the small intestine, the spleen, the lung, the endocrine and sebaceous glands are selected, musk rheumatalgia-relieving plasters are adopted to be attached to ears, and the auricular acupoints are pressed six times every day and must be pressed ten minutes before a meal. The traditional Chinese medicine is used for treating NAFLD, has few toxic or side effects, can regulate functions of viscera, reduce the appetite, regulate the endocrine, increase the cure rate of NAFLD and treat fatty liver and reduces the probability that fatty liver develops towards fatty liver hepatitis and liver cirrhosis. Besides, the auricular acupoints are pressed, so that the functions of viscera are regulated, the appetite is reduced, and the endocrine is regulated. The two methods perform functions synergistically, and the effect is satisfactory.
Description
Technical field
The present invention relates to a kind of clutch, especially relate to a kind of Chinese traditional medicines depressing lipid for the treatment of non-alcohol fatty liver.
Background technology
Non-alcohol fatty liver (NAFLD) sickness rate, in ascendant trend year by year, has become one of common chronic disease.The related drugs being used for the treatment of NAFLD at present comprises the classifications such as euglycemic agent, appetrol, fat regulation medicine, depressor, antioxidant, cytoprotective, anti-inflammatory cytokines and intestinal microecology adjusting agent.There is the potential untoward reaction bringing out mitochondrial function infringement in view of observing euglycemic agent, appetrol, fat regulation medicine and depressor etc., therefore need that a kind of curative effect is good and side effect is less medicine is used for the treatment of non-alcohol fatty liver.
Summary of the invention
The technical problem that the present invention solves is: provide one can regulating functions of ZANG FU-organs, the Chinese traditional medicines depressing lipid for the treatment of non-alcohol fatty liver.
Base case of the present invention is: a kind of Chinese traditional medicines depressing lipid for the treatment of non-alcohol fatty liver, and it is held to levy and is: parts by weights meter comprises following component: Poria 25-30g, Rhizoma Atractylodis Macrocephalae 25-30g, Rhizoma Alismatis 8-15g, Radix Angelicae Sinensis 10-15g, Radix Salviae Miltiorrhizae 20-30g, Fructus Crataegi 15-30g, Herba Lycopi 6-12g, Scorpio 4-8g, Periostracum Cicadae 7-12g, Hirudo 8-15g, Carapax Trionycis 10-20g (first), Radix Astragali 20-30g.Poria, Rhizoma Alismatis, Rhizoma Atractylodis Macrocephalae invigorating the spleen to clear away damp pathogen in side; Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Fructus Crataegi blood circulation promoting and blood stasis dispelling; Herba Lycopi's activating blood and promoting diuresis; Scorpio, Periostracum Cicadae expel wind to dredge collateral; Hirudo is searched and picks disperse blood stasis and dredge collateral; Carapax Trionycis resolving mass and removing the obstruction of the collateral; The righting of Radix Astragali QI invigorating also can help wind medicine to get rid of evils and goes out and just do not hinder.Modern pharmacological research shows, Radix Salviae Miltiorrhizae, Fructus Crataegi etc. have effect for reducing fat, and Radix Angelicae Sinensis, the Radix Astragali etc. have liver protection effect, and Rhizoma Alismatis has lipotropy.
In some embodiments, parts by weights meter comprises following component: Poria 30g, Rhizoma Atractylodis Macrocephalae 30g, Rhizoma Alismatis 15g, Radix Angelicae Sinensis 15g, Radix Salviae Miltiorrhizae 30g, Fructus Crataegi 30g, Herba Lycopi 12g, Scorpio 6g, Periostracum Cicadae 12g, Hirudo 10g, Carapax Trionycis 20g (first), Radix Astragali 20g.
In some embodiments, parts by weights meter also comprises following component: Rhizoma Corydalis 3-10 gram, Fructus Toosendan 3 ~ 10g.Be applicable to the obvious person of liver pain.
In some embodiments, parts by weights meter also comprises following component: Rhizoma Atractylodis 5-10g, Semen Alpiniae Katsumadai 3 ~ 6g, Semen Plantaginis 10 ~ 15g.Be applicable to the obvious person of damp.
In some embodiments, parts by weights meter also comprises following component: Pericarpium Citri Reticulatae 10-15 gram, Arisaema Cum Bile 3 ~ 6g.Be applicable to the turbid obvious person of expectorant.
In some embodiments, parts by weights meter also comprises following component: Radix Scutellariae 5 ~ 10 grams, Herba Sedi 15 ~ 20g.Be applicable to the obvious person of thermal image.
The another technical problem that the present invention solves is: provide one can regulating functions of ZANG FU-organs, the Therapeutic Method for the treatment of non-alcohol fatty liver.
A kind of Therapeutic Method for the treatment of non-alcohol fatty liver, the Chinese traditional medicines depressing lipid of the treatment non-alcohol fatty liver described in the above any one of the right to use, by the Chinese traditional medicines depressing lipid potion every day decoction of described treatment non-alcohol fatty liver, sooner or later oral at twice; Adopt Wang Anyi Putting and massaging on auricular points, acupoint selection: Shenmen, stomach, small intestinal, spleen, lung, endocrine, sebaceous gland, and paste ear with SHEXIANG ZHUIFENG GAO, press 6 every day, ten minutes ante cibum must press.
Advantage of the present invention is: use Chinese traditional medicines depressing lipid for oral administration, treatment by Chinese herbs, toxic and side effects is little, adjustable function, reduce appetite, endocrine regulation, improve the cure rate of non-alcohol fatty liver (NAFLD), treatment fatty liver, reduces the development of fatty liver to fat hepatitis, liver cirrhosis.Coordinate ear acupoint pressing, adjustable function simultaneously, reduce appetite, endocrine regulation.Two kinds of methods, work in coordination with mutually, therefore get effect satisfaction.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, and embodiment is obtain preparation example and use this preparation example to carry out clinical treatment observation the mode combined.
Non-alcohol fatty liver (NAFLD) patient 80 example is selected to be divided into treatment group and each 40 examples of matched group at random.Matched group adopts Zhibituo.
Embodiment one
Treatment group adopts the Chinese traditional medicines depressing lipid combining oral ear acupoint to bury seed treatment.
Parts by weights meter comprises following component (individual consumption): Poria 30g, Rhizoma Atractylodis Macrocephalae 30g, Rhizoma Alismatis 15g, Radix Angelicae Sinensis 15g, Radix Salviae Miltiorrhizae 30g, Fructus Crataegi 30g, Herba Lycopi 12g, Scorpio 6g, Periostracum Cicadae 12g, Hirudo 10g, Carapax Trionycis 20g (first), Radix Astragali 20g.
By fried for above dose, every day, potion, sooner or later oral at twice.Wang Anyi Putting and massaging on auricular points.Acupoint selection: Shenmen, stomach, small intestinal, spleen, lung, endocrine, sebaceous gland.Paste ear with SHEXIANG ZHUIFENG GAO, press 6 every day, ten minutes ante cibum must press.
Fatty liver is the adipose metabolism function generation obstacle that a variety of causes causes, and causes liver TG to accumulate too much a kind of pathological state.Liver is the hinge of body fat metabolism, and intrahepatic fat is mainly derived from food and peripheral tissues.When absorption hyperliposis, hyper acid for fatty tissue release free-fat, and hepatocyte synthesis TG ability strengthens, and intrahepatic fat acid-utilising reduces, and very low density lipoprotein (VLDL) synthesis and paracrisis etc. all can cause fatty liver.If primary disease malpractice, can to fat hepatitis, cirrhosis progress.
Although fatty liver without corresponding name of disease, sporadically appears in the disease such as the traditional Chinese medical science it " phlegm syndrome ", " hypochondriac pain ", " long-pending card ", " feeling of fullness " in the traditional Chinese medical science.Chinese medicine is thought, fatty liver is due to surfeit delicious food savoury, gets ill from overeating and hinders stomach, or lying on bed for a long time sitting, the rich abundant expectoration of body, or internal injury caused by excess of seven emotions causes the liver failing to maintain the normal flow of QI, spleen fortune mistake department, retention of water-damp in the body, the turbid interior life of expectorant, qi depression to blood stasis and being formed.Therefore the most replenishing QI to invigorate the spleen of the Chinese traditional treatment of fatty liver, eliminate the phlegm disappearing and become silted up for method.Fatty liver is at channels, and channels is the branch of passages through which vital energy circulates, and channels is tiny, is the end of QI-blood circulation, slow blood flow, and evil stagnant difficulty is dispelled, and only the insect medicine of expel wind to dredge collateral can arrive at disease institute, gets rid of evils outer for network.Poria, Rhizoma Alismatis, Rhizoma Atractylodis Macrocephalae invigorating the spleen to clear away damp pathogen in side; Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Fructus Crataegi blood circulation promoting and blood stasis dispelling; Herba Lycopi's activating blood and promoting diuresis; Scorpio, Periostracum Cicadae expel wind to dredge collateral; Hirudo is searched and picks disperse blood stasis and dredge collateral; Carapax Trionycis resolving mass and removing the obstruction of the collateral; The righting of Radix Astragali QI invigorating also can help wind medicine to get rid of evils and goes out and just do not hinder.Coordinate ear acupoint pressing, adjustable function simultaneously, reduce appetite, endocrine regulation.Two kinds of methods, work in coordination with mutually, therefore get effect satisfaction.Modern pharmacological research shows, Radix Salviae Miltiorrhizae, Fructus Crataegi etc. have effect for reducing fat, and Radix Angelicae Sinensis, the Radix Astragali etc. have liver protection effect, and Rhizoma Alismatis has lipotropy.
Matched group takes Zhibituo (Chengdu Diao 9 Wang pharmaceutical factory, the accurate word Z51022196 of traditional Chinese medicines), and each one (every 0.24g) is every day 2 times, oral.Two groups all do not use other to the influential medicine of fatty liver, are a course for the treatment of with one month, treat all continuously for two groups and observe clinical efficacy 3 courses for the treatment of.Observe patient clinical symptom, sign, liver function, blood fat and liver B ultrasonic index respectively.
Primary Care two groups of patients all give low fat diet under dietician and clinician directs, and three major nutrient cubage is with reference to " medical nutriology " related request: limit sweet food, avoid fat meat, prohibit drink, moderate exercise etc.Primary Care scheme brochure is provided in time during patient's first visit, dietetic care and movement technique are directed concretely, inquire the implementation status of dietetic care and modest movement during patient's further consultation all in detail, supervise in time and instruct, to strengthen the compliance of the conscious execution Primary Care of patient.
Observation index: (1) clinical symptoms, sign, comprises uncomfortable liver area, weak, dyspepsia etc.; (2) liver function: Serum ALT, AST, gamma glutamyl transpeptidase (GGT); (3) blood fat: serum triglycerides (TG), middle cholesterol (TC), HDL-C (HDL-C), low-density lipoprotein cholesterol (LDL-C); (4) liver B ultrasonic is looked into once before treatment and at the end of each course for the treatment of; (5) above indices all checks before the treatment with at the end of each course for the treatment of, with comprehensive observing clinical efficacy.
Criterion of therapeutical effect: cure: clinical symptom disappearance, ALT, AST, γ-GT, blood fat and liver B ultrasonic recover normal; Effective: clinical symptom disappearance, ALT, AST, γ-GT, blood fat and liver B ultrasonic are all close to normal; Invalid: clinical symptoms sustainable existence, unchanged even ALT, AST, γ-GT of auxiliary examination raises, and B ultrasonic shows that luminous point continues to increase thick or fibrosis.
Statistical method: data are all used
represent, measurement data t checks, enumeration data x
2inspection.
Result: two groups of patient clinical comparitive study treatment group 40 examples, cures 16 examples, effective 20 examples, invalid 4 examples, total effective rate 90%.
Matched group 40 example, cures 16 examples, effective 14 examples, invalid 10 examples, total effective rate 75%.Two groups of comparing differences have significant (P<0.05), and treatment group curative effect is apparently higher than matched group.
Changes of liver function before and after patient treatment of organizing table 1 liang compares (
u/l)
Before and after table 2 liang group patient treatment blood fat change and compare (
mmol/l)
With this group before treatment, * P<0.05**P<0.01
Also can take to add taste method at treatments period:
According to the difference of indivedual body constitution, can other medicines be added, with by the extremely better level of internal organs function point analysis in health, improve patient's body constitution, strengthen curative effect.
Person as obvious in liver pain, parts by weights meter adds following component again: Rhizoma Corydalis 3-10 gram, Fructus Toosendan 3 ~ 10g.
Person as obvious in damp, parts by weights meter adds following component again: Rhizoma Atractylodis 5-10g, Semen Alpiniae Katsumadai 3 ~ 6g, Semen Plantaginis 10 ~ 15g.
Obvious person as turbid in expectorant, parts by weights meter adds following component again: Pericarpium Citri Reticulatae 10-15 gram, Arisaema Cum Bile 3 ~ 6g.
Person as obvious in thermal image, parts by weights meter adds following component again: Radix Scutellariae 5 ~ 10 grams, Herba Sedi 15 ~ 20g.
Use Chinese traditional medicines depressing lipid for oral administration, treatment by Chinese herbs, toxic and side effects is little, adjustable function, reduces appetite, endocrine regulation, improve the cure rate of non-alcohol fatty liver (NAFLD), treatment fatty liver, reduce the development of fatty liver to fat hepatitis, liver cirrhosis.Coordinate ear acupoint pressing, adjustable function simultaneously, reduce appetite, endocrine regulation.Two kinds of methods, work in coordination with mutually, therefore get effect satisfaction.Curative effect is better than Zhibituo matched group, clinical can wide popularization and application.
Embodiment two
Same treatment group adopts the Chinese traditional medicines depressing lipid combining oral ear acupoint to bury seed treatment.Be with the difference of embodiment one, parts by weights meter comprises following component (individual consumption): Poria 25g, Rhizoma Atractylodis Macrocephalae 25g, Rhizoma Alismatis 8g, Radix Angelicae Sinensis 10g, Radix Salviae Miltiorrhizae 20g, Fructus Crataegi 20g, Herba Lycopi 8g, Scorpio 4g, Periostracum Cicadae 10g, Hirudo 10g, Carapax Trionycis 15g (first), Radix Astragali 20g.
Same, at treatments period, according to the difference of indivedual body constitution, can other medicines be added, with by internal organs function point analysis in health to better level.
Primary Care, observation index, criterion of therapeutical effect, statistical method take identical standard, and result shows:
Treatment group 40 example, cures 12 examples, effective 23 examples, invalid 5 examples, total effective rate 87.5%.
Matched group 40 example, cures 16 examples, effective 14 examples, invalid 10 examples, total effective rate 75%.
Two groups of comparing differences have significant (P<0.05), and treatment group curative effect is apparently higher than matched group.
In a word, the Chinese traditional medicines depressing lipid combining oral ear acupoint bury seed treatment non-alcohol fatty liver evident in efficacy.The present invention is by Chinese traditional medicines depressing lipid treatment non-alcohol fatty liver for oral administration, and treatment group clinical symptoms, sign are improved obviously, obtain good efficacy person's side effect little.Coordinate ear acupoint pressing, adjustable function simultaneously, reduce appetite, endocrine regulation.Two kinds of methods, mutually work in coordination with, curative effect is got twice the result with half the effort.For Chinese medicine fatty liver, reduce fatty liver and provide new thinking to the development of fat hepatitis, liver cirrhosis, apply to clinically can reduce medical treatment cost, improve patients ' life quality, be applicable to wide popularization and application, obtain good social benefit.
Certain above-mentioned example, only for technical conceive of the present invention and feature are described, its object is to person skilled in the art can be understood content of the present invention and implement according to this, can not limit the scope of the invention with this.All modifications done according to the spirit of main technical schemes of the present invention, all should be encompassed within protection scope of the present invention.
Claims (7)
1. treat a Chinese traditional medicines depressing lipid for non-alcohol fatty liver, it is held to levy and is: parts by weights meter comprises following component: Poria 25-30g, Rhizoma Atractylodis Macrocephalae 25-30g, Rhizoma Alismatis 8-15g, Radix Angelicae Sinensis 10-15g, Radix Salviae Miltiorrhizae 20-30g, Fructus Crataegi 15-30g, Herba Lycopi 6-12g, Scorpio 4-8g, Periostracum Cicadae 7-12g, Hirudo 8-15g, Carapax Trionycis 10-20g(first under), Radix Astragali 20-30g.
2. the Chinese traditional medicines depressing lipid for the treatment of non-alcohol fatty liver according to claim 1, is characterized in that, parts by weights meter comprises following component: Poria 30g, Rhizoma Atractylodis Macrocephalae 30g, Rhizoma Alismatis 15g, Radix Angelicae Sinensis 15g, Radix Salviae Miltiorrhizae 30g, Fructus Crataegi 30g, Herba Lycopi 12g, Scorpio 6g, Periostracum Cicadae 12g, Hirudo 10g, Carapax Trionycis 20g(first under), Radix Astragali 20g.
3. the Chinese traditional medicines depressing lipid for the treatment of non-alcohol fatty liver according to claim 1, is characterized in that, parts by weights meter also comprises following component: Rhizoma Corydalis 3-10 gram, Fructus Toosendan 3 ~ 10g.
4. the Chinese traditional medicines depressing lipid for the treatment of non-alcohol fatty liver according to claim 1, is characterized in that, parts by weights meter also comprises following component: Rhizoma Atractylodis 5-10g, Semen Alpiniae Katsumadai 3 ~ 6g, Semen Plantaginis 10 ~ 15g.
5. the Chinese traditional medicines depressing lipid for the treatment of non-alcohol fatty liver according to claim 1, is characterized in that, parts by weights meter also comprises following component: Pericarpium Citri Reticulatae 10-15 gram, Arisaema Cum Bile 3 ~ 6g.
6. the Chinese traditional medicines depressing lipid for the treatment of non-alcohol fatty liver according to claim 1, is characterized in that, parts by weights meter also comprises following component: Radix Scutellariae 5 ~ 10 grams, Herba Sedi 15 ~ 20g.
7. treat the Therapeutic Method of non-alcohol fatty liver for one kind, use the Chinese traditional medicines depressing lipid of the treatment non-alcohol fatty liver in claim 1-6 described in any one, it is characterized in that, by the Chinese traditional medicines depressing lipid potion every day decoction of described treatment non-alcohol fatty liver, sooner or later oral at twice; Adopt Wang Anyi Putting and massaging on auricular points, acupoint selection: Shenmen, stomach, small intestinal, spleen, lung, endocrine, sebaceous gland, and paste ear with SHEXIANG ZHUIFENG GAO, press 6 every day, ten minutes ante cibum must press.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115869358A (en) * | 2022-12-13 | 2023-03-31 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine composition for treating non-alcoholic fatty liver disease and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488850A (en) * | 2011-12-31 | 2012-06-13 | 黄文珍 | Traditional Chinese medicinal composition for treating alcoholic fatty liver and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488850A (en) * | 2011-12-31 | 2012-06-13 | 黄文珍 | Traditional Chinese medicinal composition for treating alcoholic fatty liver and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 周琴: "降脂汤内服结合耳穴埋籽治疗非酒精性脂肪性肝病40例", 《第二十一届全国中西医结合消化系统疾病学术会议暨国家级中西医结合消化系统疾病新进展学习班论文汇编》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115869358A (en) * | 2022-12-13 | 2023-03-31 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine composition for treating non-alcoholic fatty liver disease and application thereof |
| CN115869358B (en) * | 2022-12-13 | 2023-09-05 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine composition for treating non-alcoholic fatty liver disease and application thereof |
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