CN105326985A

CN105326985A - Traditional Chinese medicinal preparation for treating cold dampness closed resistance-type rheumatoid knee arthritis

Info

Publication number: CN105326985A
Application number: CN201510835552.9A
Authority: CN
Inventors: 张娟
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-11-19
Filing date: 2015-11-19
Publication date: 2016-02-17

Abstract

The invention discloses a traditional Chinese medicinal preparation for treating cold dampness closed resistance-type rheumatoid knee arthritis, and belongs to the technical field of traditional Chinese medicines. Aiming at the incidence reason of the cold dampness closed resistance-type rheumatoid knee arthritis, the traditional Chinese medicinal preparation is prepared into decoction by decocting the following traditional Chinese medicines, namely orange jessamine root, Chinese photinia leaf, oblongleaf kadsura stem root, root of procumbent Indian mallow, hemiphragma heterophyllum, arachnoid cyanotis root, the root of berchemia kulingensis schneid, drymaria diandra, white peel of aralia chinensis, the root of camphor tree, the root or leaf of Narrowleaf Burmann cinnamon and pteris nervosa, with water. Through a clinical trial, the total effective rate of the traditional Chinese medicinal preparation is up to 92 percent.

Description

A kind of Chinese medicine preparation for the treatment of cold-damp impatency type rheumatoid gonarthritis

Technical field

The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of Chinese medicine preparation for the treatment of cold-damp impatency type rheumatoid gonarthritis.

Background technology

Rheumatoid arthritis is also known as rheumatoid, and the chronic generalized autoimmune disease of feature that to be a kind of with articular synovitis be, belongs to traditional Chinese medical science arthromyodynia category.The lasting recurrent exerbation of synovitis, can cause the destruction of intraarticular cartilage and bone, joint function disturbance, even maimed.Current doctor trained in Western medicine does not also have ability that the pathology of rheumatoid arthritis is reversed, and patient can only use analgesic, pain killer injection, anesthesia needle etc. to carry out relief of symptoms.Applicant, in clinical practice for many years, according to theory of Chinese medical science, utilizes treatment by Chinese herbs rheumatoid arthritis, not only achieves good curative effect, and patient's no pain, without complication, and safe and convenient.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of cold-damp impatency type rheumatoid gonarthritis.Motherland's medical science thinks that this disease attacks human body in an opponent's defence primarily of the heresy of wind, cold, wet, heat, and cause QI-blood circulation not smooth, blockage of meridian, muscle arteries and veins joint is lost in moistening foster.Arthromyodynia from the beginning of, be not difficult to be cured, but late period, the course of disease was touching.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment rheumatoid gonarthritis is made up of the Chinese medicine of following weight portion: Radix Murrayae 12-16 part, Folium Photiniae (Folium Photiniae serrulatae) 6-12 part, Caulis Seu Radix Kadsurae Oblongifoliae 12-18 part, Radix urenae procumbentis 5-12 part, Herba hemipharagmatis heterophylli 12-20 part, Radix Cyanotis arachnoideae 5-9 part, Radix berchemiae kulingensis 20-30 part, Herba drymariae cordatae 10-14 Fen, Cortex araliae chinensis 12-18 part, Radix litseae rubescentis 5-12 part, Radix seu Folium Cinnamomi angustifolii 9-14 part, Herba Pteridis multifidae 12-16 part.

Preferred: Radix Murrayae 14 parts, Folium Photiniae (Folium Photiniae serrulatae) 9 parts, Caulis Seu Radix Kadsurae Oblongifoliae 15 parts, Radix urenae procumbentis 9 parts, Herba hemipharagmatis heterophylli 16 parts, Radix Cyanotis arachnoideae 7 parts, Radix berchemiae kulingensis 25 parts, Herba drymariae cordatae 12 Fen, Cortex araliae chinensis 15 parts, Radix litseae rubescentis 9 parts, Radix seu Folium Cinnamomi angustifolii 12 parts, Herba Pteridis multifidae 14 parts.

Preparation method: traditionally make decoction.

Fang Zhong: the pain relieving of Radix Murrayae scattered silt, dispelling the wind and dampness pathogens arthralgia pain; Folium Photiniae (Folium Photiniae serrulatae) dispelling wind and removing obstruction in the collateral, kidney tonifying; Caulis Seu Radix Kadsurae Oblongifoliae wind-damp dispelling and the intestines and stomach, promoting the circulation of QI to relieve pain; Radix urenae procumbentis invigorating the spleen to clear away damp pathogen, blood stasis dispelling are invigorated blood circulation; Herba hemipharagmatis heterophylli benefiting qi and checking blood, hemostasis by removing blood stasis, dehumidifying dispel the wind; Radix Cyanotis arachnoideae promoting flow of qi by warming channel, removing damp and stopping pain, treating rheumatic arthritis, numb limbs and tense tendons; Radix berchemiae kulingensis dispelling the wind and dampness pathogens arthralgia pain; Herba drymariae cordatae heat-clearing and toxic substances removing; Cortex araliae chinensis dispelling the wind and dampness pathogens arthralgia pain, traumatic injury; Radix litseae rubescentis expelling wind and cold; Radix seu Folium Cinnamomi angustifolii relaxing muscles and tendons and activating QI and blood in the collateral, dispersing cold for relieving pain; Herba Pteridis multifidae heat-clearing and toxic substances removing, diuresis of blood circulation promoting.

Clinical data

1, physical data is between in March ,-2013 in February, 2010, meets subject 100 routine patients, be divided into treatment group and matched group at random in the court.Treatment group 50 example, wherein male 26 example, women 24 example; Age 21-73 year; Matched group 50 example, male 25 example, women 25 example; At 22 ~ 71 years old age, two groups of no difference of science of statistics in sex, age, the course of disease, the state of an illness (P > 0.05), have comparability.

2, diagnostic criteria Syndrome Diagnostic meets the TCM syndrome diagnostic criteria in " the new Chinese medicine treatment rheumatoid arthritis guideline of clinical investigations " of National Drug Administration's promulgation in 2002.Exclusion standard for 1. not meeting in rheumatoid arthritis, Western medicine diagnose standard person; 2. long-term taking antirheumatic, cell toxicity medicament, glucocorticoid, and user is not stopped at least 1 week before this research; 3. gestation or women breast-feeding their children, those who are allergic to this drug; 4. late deformity is serious, even maimed, the person of can't take care of oneself; Merge intentionally, brain, liver, the serious disease such as kidney and hemopoietic system patient; 5. other rheumatisms overlapping, as systemic lupus erythematosus (sle), sjogren syndrome, serious Patients with Knee Osteoarthritis.

3, Therapeutic Method treatment group: the Chinese medicine preparation taking treatment rheumatoid gonarthritis of the present invention, its prescription is: Radix Murrayae 14g, Folium Photiniae (Folium Photiniae serrulatae) 9g, Caulis Seu Radix Kadsurae Oblongifoliae 15g, Radix urenae procumbentis 9g, Herba hemipharagmatis heterophylli 16g, Radix Cyanotis arachnoideae 7g, Radix berchemiae kulingensis 25g, Herba drymariae cordatae 12g, Cortex araliae chinensis 15g, Radix litseae rubescentis 9g, Radix seu Folium Cinnamomi angustifolii 12g, Herba Pteridis multifidae 14g, every day potion, traditionally make decoction, point morning and evening decoction being taken warmly; Matched group: give meloxicam tablet and the treatment of hydroxychloroquine sulfate sheet.Meloxicam tablet (the accurate word H20010207 of traditional Chinese medicines, Yangzijiang Pharmaceutical Group Co., Ltd), oral, take with water or liquid and swallow, every day 2 times, each 7.5mg (1); Hydroxychloroquine sulfate sheet (the accurate word H19990263 of traditional Chinese medicines, Shanghai Zhongxi Pharmaceutical Co., Ltd.), oral, every day 3 times, each 0.1g (1).Two groups equal 15 days is 1 course for the treatment of, treats 3 courses for the treatment of continuously.

4, efficacy assessment standard recovery from illness: clinical symptoms, sign disappear, arthralgia, swelling disappear, and movable function is normal, and laboratory checking index is normal; Effective: clinical symptoms, sign significantly alleviate or take a turn for the better, arthralgia, swelling obviously alleviate, and movable function significantly takes a turn for the better, and laboratory checking index recovers close to normal; Effective: clinical symptoms, sign make moderate progress, arthralgia, swelling have certain alleviating, and movable function takes a turn for the better to some extent, and laboratory checking index takes a turn for the better; Invalid: clinical symptoms, sign are improved not obvious, arthralgia, swelling are unchanged, and movable function is without improvement, and laboratory checking index is unchanged.

5 therapeutic outcome two groups comparitive study see the following form.Total effective rate=recovery from illness+effective+effectively/n × 100%.

Group	n	Recovery from illness	Effective	Effectively	Invalid	Total effective rate
							Treatment group	50	16	25	5	4	92％
Matched group	50	10	16	8	16	68％

Treatment group therapeutic effect is significantly better than matched group.

6, model case Liu, female, 52 years old, living environment was moist, and over nearly 2 years, often feel two gonalgia swelling, weigh, play stiff at least 1h morning, joint stuffiness, overcast and rainy exacerbation of symptoms, very then lies awake all night whenever, pain alleviated while getting warmth.Dimly pale tongue, white and thin fur is greasy, stringy and tense pulse, then according to erythrocyte sedimentation rate, anti-" 0 ", rheumatoid factor and x line, be diagnosed as rheumatoid gonarthritis, and card belongs to cold-damp impatency type arthromyodynia.Treatment gives Chinese medicine preparation of the present invention to be treated, treat 3 courses for the treatment of continuously, pain, swelling, stiff basic disappearance in morning, normally, rheumatoid factor transfers feminine gender to check erythrocyte sedimentation rate.Follow up a case by regular visits to March, pain is without recurrence.

Detailed description of the invention

Embodiment one: take Radix Murrayae 12g, Folium Photiniae (Folium Photiniae serrulatae) 6g, Caulis Seu Radix Kadsurae Oblongifoliae 12g, Radix urenae procumbentis 5g, Herba hemipharagmatis heterophylli 12g, Radix Cyanotis arachnoideae 5g, Radix berchemiae kulingensis 20g, Herba drymariae cordatae 10g, Cortex araliae chinensis 12g, Radix litseae rubescentis 5g, Radix seu Folium Cinnamomi angustifolii 9g, Herba Pteridis multifidae 12g, traditionally make decoction.

Embodiment two: take Radix Murrayae 14g, Folium Photiniae (Folium Photiniae serrulatae) 9g, Caulis Seu Radix Kadsurae Oblongifoliae 15g, Radix urenae procumbentis 9g, Herba hemipharagmatis heterophylli 16g, Radix Cyanotis arachnoideae 7g, Radix berchemiae kulingensis 25g, Herba drymariae cordatae 12g, Cortex araliae chinensis 15g, Radix litseae rubescentis 9g, Radix seu Folium Cinnamomi angustifolii 12g, Herba Pteridis multifidae 14g, traditionally make decoction.

Embodiment three: take Radix Murrayae 16g, Folium Photiniae (Folium Photiniae serrulatae) 12g, Caulis Seu Radix Kadsurae Oblongifoliae 18g, Radix urenae procumbentis 12g, Herba hemipharagmatis heterophylli 20g, Radix Cyanotis arachnoideae 9g, Radix berchemiae kulingensis 30g, Herba drymariae cordatae 14g, Cortex araliae chinensis 18g, Radix litseae rubescentis 12g, Radix seu Folium Cinnamomi angustifolii 14g, Herba Pteridis multifidae 16g, traditionally make decoction.

Claims

1. treat a Chinese medicine preparation for cold-damp impatency type rheumatoid gonarthritis, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Radix Murrayae 12-16 part, Folium Photiniae (Folium Photiniae serrulatae) 6-12 part, Caulis Seu Radix Kadsurae Oblongifoliae 12-18 part, Radix urenae procumbentis 5-12 part, Herba hemipharagmatis heterophylli 12-20 part, Radix Cyanotis arachnoideae 5-9 part, Radix berchemiae kulingensis 20-30 part, Herba drymariae cordatae 10-14 part, Cortex araliae chinensis 12-18 part, Radix litseae rubescentis 5-12 part, Radix seu Folium Cinnamomi angustifolii 9-14 part, Herba Pteridis multifidae 12-16 part.

2. a kind of Chinese medicine preparation for the treatment of cold-damp impatency type rheumatoid gonarthritis as claimed in claim 1, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: preferred: Radix Murrayae 14 parts, Folium Photiniae (Folium Photiniae serrulatae) 9 parts, Caulis Seu Radix Kadsurae Oblongifoliae 15 parts, Radix urenae procumbentis 9 parts, Herba hemipharagmatis heterophylli 16 parts, Radix Cyanotis arachnoideae 7 parts, Radix berchemiae kulingensis 25 parts, Herba drymariae cordatae 12 Fen, Cortex araliae chinensis 15 parts, Radix litseae rubescentis 9 parts, Radix seu Folium Cinnamomi angustifolii 12 parts, Herba Pteridis multifidae 14 parts.