CN105326917A - Composition capable of relieving epicophosis and preparation method thereof - Google Patents
Composition capable of relieving epicophosis and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses a composition capable of relieving epicophosis. The composition is mainly prepared from, by weight, 9-30 parts of securinega suffruticosa, 6-12 parts of glossy privet fruit, 6-9 parts of stellaria yunnanensis, 10-15 parts of rust-coloured crotalaria herb with roots, 1.5-3 parts of semen cuscutae, 9-15 parts of irkutsk anemone rhizome, 4.5-9 parts of angelica sinensis, 3-12 parts of puerarin, 10-25 parts of atractylodes macrocephala koidz, 6-9 parts of common selfheal fruit-spike, 3-9 parts of caulis akebiae, 5-15 parts of honeysuckle and 6-9 parts of phillyrin. The composite has remarkable effects on tinnitus and epicophosis, has functions of promoting blood circulation to remove stasis, promoting qi circulation and opening orifices, and tonifying qi and recovering audition, soothes annoyed feelings caused by long-term tinnitus and epicophosis to patients, is mostly prepared from local commonly-seen medicine materials, is low in price and relieves economic burdens on patients.
Description
Technical field
The invention discloses a kind of compositions, especially a kind of composition and method of making the same alleviating deafness.The invention belongs to traditional Chinese medicine field.
Background technology
Acoustic nerve in auditory system in acoustic, phonosensitive and audition pathway thereof and maincenter generation pathological changes at different levels, cause auditory function obstacle, produces auditory dysesthesia in various degree, be referred to as deafness.It is generally acknowledged that the average threshold of audibility of language frequency is referred to as auditory dysesthesia or dysaudia when more than 26dB.Different according to the degree of auditory dysesthesia, also known as be hard of hearing, dysaudia, auditory dysesthesia, auditory dysesthesia etc.
The cause of disease: the deaf cause of disease is complicated, has congenital and posteriority factor, and wherein suppurative otitis media topmostly in transmission deafness causes deaf disease.In recent years, secretory otitis media becomes the main cause of child's auditory dysesthesia.Four classes can be divided into: i.e. conductive deafness, sensorineural deafness, mixed deafness and central deafness by diseased region and character deafness.1. the cause of disease (1) of conductive deafness is congenital common are congenital malformation, comprises the deformity of external ear, middle ear, such as congenital atresia of external auditory meatus or tympanum, ear bones, fenestra cochleae, vestibuli hypoplasia etc.(2) posteriority external auditory meatus is blocked, as ceruminal impaction, bone wart, foreign body, tumor, inflammation etc.Middle otopyosis or nonsuppurative inflammation make middle ear acoustic dysfunction, or Ear Trauma makes ossicular chain impaired, and middle ear are optimum, malignant tumor or otosclerosis etc.2. the cause of disease of sensorineural deafness: (1) is congenital normal caused by internal ear acoustic nerve hypoplasia, or trimester of pregnancy be infected by the virus or take ototoxic drug and cause, or injured etc. during childbirth.The deafness that linked congenital inner ear malformation causes is phonosensitive nerve deafness.According to internal ear x-ray layer radiography and embryogenesis, inner ear malformations is fallen into 5 types, namely lost disappearance, together allocation, cochlea do not grow, cochlea hypoplasia and incomplete separation type.In addition large aquaductus vestibuli syndrome is also the common linked congenital inner ear malformation causing phonosensitive nerve deafness.Congenital deafness in phonosensitive nerve deafness can also comprise nongenetic and heritability.Trimester of pregnancy is infected by the virus, take the injured deafness caused when ototoxic drug causes or gives a birth is that nongenetic is deaf.Nongenetic comprises pregnancy period application ototoxic drug, pregnancy period viral infection, syphilis, bacteriological infection, anoxia neonatorum, maternal infuries, hyperbilirubinemia of newborn; In addition nongenetic also comprise noise exposure, childbirth time injury of head, radiation exposure etc.Hereditary hearing impairment is that gene change and cause, and nongenetic and the sickness rate both hereditary hearing impairment respectively account for 50%, and the hereditary hearing impairment patient of 70% is without other symptoms except deafness, and this kind of deafness is that non-syndrome is deaf.Hereditary hearing impairment comprises autosome feminine gender, autosomal dominant, X-is chain, Y-is chain, mitochondrion (maternal) is hereditary.At present, there will be a known a lot of gene all relevant with non-syndrome deafness, there is sudden change in one of them or several gene, or the different loci in a gene exists sudden change, all can cause deafness.But not agnate, in the crowd of even same ethnic different regions, deaf gene and mutational site thereof are not quite similar.Correlational study display GJB2, SLC26A4, the mitochondrial gene (A1555G and C1494T sudden change) of China are the most common genes of three of causing most of China hereditary hearing impairment to occur, hereditism is carried out to this few gene and detects the genetic factors can specifying in deaf crowd 40%, the hereditary hearing impairment of more than 95% can be diagnosed in conjunction with family history analysis and having a medical check-up.The examination of deaf gene and be detected as the prevention of congenital phonosensitive nerve deafness, reduces its sickness rate and provides probability.[1-4] (2) posteriority 1. deafness due to infective disease: various acute infectious disease, bacillary or viral infection, all can damage internal ear as epidemic encephalitis type B, mumps, purulent meningitis, measles, scarlet fever, influenza, zoster oticus, typhoid fever etc. and the sensorineural deafness causing weight different.2. deafness resulting from drug toxicity: be more common in aminoglycosides antibiotics, as gentamycin, kanamycin, polymyxin, dihydrostreptomycin, neomycin etc., other drug such as quinine, salicylic acid, cisplatin etc. all can cause sensorineural deafness, and the susceptibility of drug intoxication of ear and body has substantial connection.Deafness resulting from drug toxicity is bilateral, and how with tinnitus, vestibular function also can damage.Middle ear drip for a long time and also infiltrate internal ear by secondary tympanic membrane with this type of medicine, should note.(3) presbycusis is many makes blood supply insufficiency because of sclerosis of blood vessels, hyperosteogeny, degenerative lesion occurs, causes auditory dysesthesia.(4) traumatic deafness craniocerebral trauma and temporal bone fracture damage internal ear structures, cause hemorrage of inner ear, or cause cochlea damage because strongly shaking, and all can cause sensorineural deafness, sometimes accompanies tinnitus, dizzy.The lighter can recover.Otologic surgical procedurese accidentally injures internal ear structures also can cause deafness.(5) sudden deafness is that one occurs and agnogenic sensorineural deafness suddenly.Think that acute inner ear microcirculation obstacle and viral infection are the common causes causing primary disease at present more.(6) what explosive deafness system caused due to the crunch ripple that occurs suddenly and high power pulse noise listens device acute injury.Tympanum and cochlea listen the most easily vulnerable position of device.When personnel are exposed to more than 90dB noise, can Cochlea be there is, if intensity is more than more than 120dB, then can cause permanent deaf.(7) noise induced hearing loss is a kind of sensorineural deafness slowly carried out owing to suffering for a long time caused by the stimulation of more than 85dB noise.Main manifestations is tinnitus, deafness, and pure tone test shows as 4000Hz paddy shape incisura or high frequency attenuation type.(8) Auditory Neuropathy Auditory Neuropathy is the comparatively special disease of a kind of clinical manifestation, main audiology's feature comprises auditory brainstem response disappearance or severely subnormal, otoacoustic emission is normal, and cochleostapedial reflex disappears or threshold value raises, and audiogram is main mainly with the loss of the low frequency threshold of audibility.The main main suit of patient be Speech recognition difference and cannot with people's normal communication.The significant difference of Auditory Neuropathy and general sensorineural deafness, is just causing increasing concern.But it is still indefinite for lapsing to of the cause of disease of this disease, pathogenesis and disease.(9) autoimmunity Autoimmune sensorineural hearing loss is the hearing loss of the phonosensitive nerve caused because autoimmune disorders causes inner ear tissue impaired, but this hearing loss Progressive symmetric erythrokeratodermia and undulatory property, monaural or ears can be involved, as its hearing loss of ears scarcely symmetrical.Autoimmune sensorineural hearing loss patient audiogram can have multiple clinically, as low frequency type, high-frequency type, flat type and bell etc., but is maximum with low frequency type.May damage prior to starting there is relation in the middle part of snail point, cochlea with this immunoreactivity of internal ear, show the deaf feature of typical snail property, this is also clinical audition one feature.(10) Meniere Meniere be a kind of agnogenic take hydrolabyrinth as the inner ear disease of major pathologic features.Its course of disease is changeable, and episodic vertigo, undulatory property deafness and tinnitus are its cardinal symptom.The etiology unknown of Meniere, may be relevant with congenital anomaly of inner ear, autonomic nervous dysfunction, viral infection, allergia, endocrine regulation, salt and water metabolism imbalance etc.Generally believe that endolymph backflow obstruction or malabsorption are main pathogenesiss at present, as narrow in endolymphatic duct or blocking; Autonomic nervous dysfunction can cause internal ear small blood vessel spasm, causes lost microcirculation disturbance, histanoxia, and endolymph biochemical characteristic changes, and osmotic pressure increases and causes hydrolabyrinth.The pathological change of primary disease is hydrolabyrinth, mainly involves membranous cochlea and sacculus.Compressing stimulates cochlea to produce the cochlea such as tinnitus, deafness symptom, and compressing stimulates vestibule end-organ and produces the vestibule symptom such as dizzy.Classical symptom is episodic vertigo, undulatory property deafness, the vexed swollen sense of tinnitus gill.3. the cause of disease acoustic of mixed deafness and phonosensitive structure have pathological changes to exist simultaneously.As long-term chronic suppurative otitis media, otosclerosis late period etc.4. the cause of disease of central deafness: the pathological changes of central deafness is positioned at brain stem and brain, causes central deaf when involving cochlear nuclei and maincenter pathway, Auditory cortex maincenter.Mainly can be divided into following two kinds: (1) brain stem sexual centre deafness involves the deafness that cochlear nucleus produces side property, mild degree; If involve the decussating fibers of side cochlear nucleus and offside, produce bilateral deaf, common with partial sensorineural deafness, be common in pons, oblongata pathological changes.(2) the cortex deafness of cortex deafness is difficult to distinguish for distinguishing apart from, character of sound, although the estheticism that general audition is sometimes without prejudice for language reduces.Because side cochlear nucleus Fiber Projections is to the Auditory cortex of bilateral, side Auditory cortex impaired generation side, side that is impaired or pathway or bilateral auditory dysesthesia.
Clinical manifestation: the common clinical disease of dysacousis has tinnitus, hyperacusis, deafness, auditory hallucination and auditory agnosia.
Alleviate in deaf method existing, Authorization Notice No. CN102614331B(application number 201210114391.0) disclose a kind of Chinese medicine preparation for the treatment of Hiccough and deaf, it is characterized in that it is made up of the crude drug of following weight portion: Rhizoma Acori Graminei 20-30 part, Flos Lonicerae 10-20 part, Fructus Forsythiae 10-20 part, Fructus Viticis 9-18 part, Fructus Arctii 9 ~ 18 parts, Flos Chrysanthemi 10-20 part, Fructus Atriplicis Sibiricae 10-20 part, Cortex Phellodendri 9-18 part, Radix Puerariae 9-18 part, Rhizoma Cimicifugae 9-18 part, Caulis Akebiae 9-20 part, Radix Codonopsis 15-30 part, Radix Paeoniae Alba 15-30 part, Radix Rehmanniae 10-20 part, Radix Platycodonis 9-18 part, Radix Glycyrrhizae 6-12 part.Authorization Notice No. CN102228626B(application number 201110156561.7) disclose a kind of Chinese medicine for the treatment of Hiccough and deaf, it is characterized by, its active component is made up of the raw material of following parts by weight: Poria cum Radix Pini 6-12 part, Os Draconis 6-12 part, Rhizoma Atractylodis Macrocephalae 3-9 part, Flos Chrysanthemi 6-12 part, Semen Ziziphi Spinosae 3-9 part, Rhizoma Phragmitis 9-15 part, Herba Plantaginis 6-12 part, Radix Rehmanniae 6-12 part, Rhizoma Acori Graminei 2-6 part, Bulbus Lilii 3-9 part, Radix Puerariae 6 ~ 12 parts, Herba Oenanthes Javanicae 9-15 part, Clinanthium Helianthi 1-5 part, Herba Crotalariae Ferrugineae 9-15 part, Semen Firmianae 1-3 part.So-called " being medicine three points of poison ", takes medicine in a large number, can cause extra burden to the health of patient.
Summary of the invention
Deaf not enough present situation is alleviated for existing, an object of the present invention is to provide a kind of and alleviates deaf compositions, has easy to operate, effect that blood circulation promoting and blood stasis dispelling, circulation of qi promoting are sensible, QI invigorating is recovered lost hearing, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Alleviate a deaf compositions, preferred proportioning, takes off the primary raw material stating weight proportion and is prepared from: Cacumen Securinegae Suffruticosae 9-30 part, Fructus Ligustri Lucidi 6-12 part, Radix Stellariae Yunnanensis 6-9 part, Herba Crotalariae Ferrugineae 10-15 part, Semen Cuscutae 1.5-3 part, Rhizoma Anemones Altaicae 9-15 part, Radix Angelicae Sinensis 4.5-9 part, Radix Puerariae 3-12 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Spica Prunellae 6-9 part, Caulis Akebiae 3-9 part, Flos Lonicerae 5-15 part, Fructus Forsythiae 6-9 part.
Alleviate a deaf compositions, more preferably proportioning, takes off the primary raw material stating weight proportion and is prepared from: Cacumen Securinegae Suffruticosae 15-25 part, Fructus Ligustri Lucidi 7-10 part, Radix Stellariae Yunnanensis 7-8 part, Herba Crotalariae Ferrugineae 12-14 part, Semen Cuscutae 2-2.5 part, Rhizoma Anemones Altaicae 10-13 part, Radix Angelicae Sinensis 5-8 part, Radix Puerariae 5-10 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Spica Prunellae 7-8 part, Caulis Akebiae 5-8 part, Flos Lonicerae 8-12 part, Fructus Forsythiae 7-8 part.
Alleviate a deaf compositions, optimum proportioning, takes off the primary raw material stating weight proportion and is prepared from: Cacumen Securinegae Suffruticosae 20 parts, Fructus Ligustri Lucidi 8 parts, Radix Stellariae Yunnanensis 7.5 parts, Herba Crotalariae Ferrugineae 13 parts, Semen Cuscutae 2.2 parts, Rhizoma Anemones Altaicae 11 parts, Radix Angelicae Sinensis 6 parts, Radix Puerariae 7 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Spica Prunellae 7.5 parts, Caulis Akebiae 6 parts, Flos Lonicerae 9 parts, Fructus Forsythiae 7.5 parts.
The preparation method of above-mentioned composition, preparation process is as follows:
1. by Cacumen Securinegae Suffruticosae, Fructus Ligustri Lucidi, Radix Stellariae Yunnanensis, Herba Crotalariae Ferrugineae, Semen Cuscutae and Rhizoma Anemones Altaicae mixing, be placed in the warm water of 30-40 DEG C, repeatedly clean 1-5 time, be placed on close grenadine cloth, be put in shady and cool ventilation place, ventilation 2-6 days, mix thoroughly with Chinese liquor and be placed in preheated container, stir-fry 5-15 minute repeatedly, dries in the air stand-by to the crisp smalls that grinds to form;
2. Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae are placed in non iron container, add Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and the Fructus Forsythiae gross weight 4-8 water being mixed with rice vinegar doubly, intense fire is fried open, turn 35-45 minute at a simmer, leach medicinal liquid stand-by;
3. by step 1. gained smalls and step 2. gained filtrate mix, decoct while stir into thick paste, thick paste is divided into two, portion white vaseline is mixed thoroughly, obtain external-applied ointment, portion mixes with Mel, and does not stop to stir 2-6 minute with waddy, refined honey becomes ball, and after dry under the environment of 50-60 DEG C, bottling sealing is for subsequent use.
The preparation method of above-mentioned composition, 1. step is placed in the warm water of 33-38 DEG C, repeatedly cleans 2-4 all over (be preferably placed in the warm water of 35 DEG C, repeatedly clean 3 times).
The preparation method of above-mentioned composition, 1. step is put in shady and cool ventilation place, ventilation 3-5 days (be preferably put in shady and cool ventilation place, ventilate 4 days).
The preparation method of above-mentioned composition, 1. step is mixed thoroughly with Chinese liquor and is placed in preheated container, and stir-fry 8-13 minute (preferably mixing thoroughly with Chinese liquor is placed in preheated container, repeatedly stir-fries 10 minutes) repeatedly.
The preparation method of above-mentioned composition, 2. step adds Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and the Fructus Forsythiae gross weight 5-7 water (preferably adding the water being mixed with rice vinegar of Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae gross weight 6 times) being mixed with rice vinegar doubly.
The preparation method of above-mentioned composition, 2. step turns 38-43 at a simmer minute (preferably turning 40 minutes at a simmer).
3. and do not stop to stir 3-5 minute (preferably and do not stop stirring 4 minutes with waddy) with waddy the preparation method of above-mentioned composition, step.
Using method: for making the present invention reach optimum therapeuticing effect, during use, getting appropriate ointment, being placed on adhesive plaster, stick after ear, every day one pastes, and uses 8 hours every day, pill 2 times on the one, sooner or later after the meal half an hour warm water delivery service, within 7 days, be a course for the treatment of.
Said composition is to tinnitus, deaf Be very effective, there is effect that blood circulation promoting and blood stasis dispelling, circulation of qi promoting are sensible, QI invigorating is recovered lost hearing, improve patient because of long-term tinnitus, deafness and the mood of agitation, and the local common medical material of multiselect of the present invention, cheap, alleviate the financial burden of patient.
Alleviate a deaf compositions, the pharmacological effect of each crude drug is respectively:
Cacumen Securinegae Suffruticosae: be browse or the root of Euphorbiaceae Suffrutescent Securinega Twig platymiscium Suffrutescent Securinega Twig.Composition: Herb contains alkaloid: Securinine, Suffrutescent Securinega Twig alkali.Containing dihydrosecurinine in leaf, securinol A, B, securinol C picrate, Bie Securinine, Securinine; Also containing phenolic constituent: Herba Euphorbiae Helioscopiae tannin B and the nor-Bergeninum of 11-O-galloyl.Containing gallic acid etc. in stem.The property of medicine: pungent, bitter, tepor, slightly poisonous.Function cures mainly: expelling wind and activating blood circulation, the strong muscle of kidney tonifying.Cure mainly lumbago due to pathogenic wind-dampness, sexual impotence, dizzy, tinnitus, deaf, facial paralysis, poliomyelitis sequela.
Fructus Ligustri Lucidi: be the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi.Composition: fruit is containing triterpenes: oleanolic acid, acetyloleanolic acid, ursolic acid, acetyl ursolic acid; Phenolic glycoside class: p-hydroxyphenylethanol, Hydroxytyrosol, nuzhenide, oleuropein, Fructus Ligustri Lucidi fruit glycosides, Fructus Ligustri Lucidi acid, Fructus Ligustri Lucidi thuja acid etc.The property of medicine: sweet, bitter, cold.Return liver, warp.Function cures mainly: liver and kidney tonifying, clearind deficient heat you, improving eyesight.Cure mainly Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.
Radix Stellariae Yunnanensis: be the root of Caryophyllaceae Stellaria plant Yunnan Herba stellariae mediae.Composition: containing peptide class: Herba stellariae mediae cyclic peptide A, B, C, D, E, F, G, false Herba stellariae mediae cyclic peptide A-H, Yunnan Herba stellariae mediae cyclic peptide A, B, D, C, E, F.The property of medicine: sweet, flat.Function cures mainly: strengthening spleen and nourishing blood, invigorating the liver and kidney, detumescence.Cure mainly anemia, dizzy nervous, tinnitus hectic fever, the soreness of waist, seminal emission, menoxenia, leukorrhagia, fracture, mastitis.
Herba Crotalariae Ferrugineae: for the false ground of pulse family Crotalaria plant is blue or the root of bar leaf Herba crotalariae mucronatae or herb.The property of medicine: bitter, micro-acid, flat.Return lung, liver, kidney channel.Function cures mainly: nourishing the liver and kidney, and cough-relieving is breathed heavily, and dampness removing cures mainly tinnitus, deaf, the vertigo, seminal emission, menorrhagia, leucorrhea, chronic cough expectorant blood, asthma, nephritis, dysuria, tonsillitis, parotitis, furuncle swelling toxin.
Semen Cuscutae: be the herb of Convolvulaceae Hellweed Semen Cuscutae.Composition: Semen Cuscutae is containing alkaloid, anthraquinone, coumarin, flavone, glycoside, sterol, tannic acid, saccharide etc.Flavonoid has: Quercetin, astragalin, hyperin; Sterols has: cholesterol, campesterol, cupreol, stigmasterol, β-Amyrin.Also trace element is contained as strontium, molybdenum, calcium, magnesium, ferrum, manganese, zinc, copper etc. and several amino acids (free amino acid in seed and the total amino acids after being hydrolyzed are 5.3%, and wherein the content of essential amino acids accounts for 42.8%).The property of medicine: micro-pungent, sweet, flat, nontoxic.Function cures mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.Rhizoma Anemones Altaicae: bitter in the mouth, pungent, slightly warm in nature.There is invigorating the liver and kidney, bone and muscle strengthening, effect of continuous injured, for soreness of the waist and knees, rheumatic arthralgia.
Radix Angelicae Sinensis: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Radix Puerariae: Radix Puerariae, Chinese medicine name.For the dry root of legume pueraria lobata, practise and claim Herba Gelsemii Elegantis.Autumn, season in winter two excavate, and take advantage of fresh-cut and become sheet or fritter; Dry.Sweet, pungent, cool.There is expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, the merit of yang invigorating antidiarrheal.Be usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Spica Prunellae: Spica Prunellae growth to be wet thick grass, wasteland, roadside at gully meadow bog or both sides, riverbank, is distributed widely in all over China, economizes as the main place of production with Henan, Anhui, Jiangsu, Hunan etc.Spica Prunellae strong adaptability, seldom has disease and pest in whole growth course.There is the effect of improving eyesight of relieving inflammation or internal heat, can conjunctival congestion and swelling pain, headache etc. be controlled.
Caulis Akebiae: bitter in the mouth, cold in nature.Gui Jing: GUIXIN, small intestinal, urinary bladder channel.Function: have inducing diuresis for treating stranguria syndrome, clear away heart-fire relieving restlessness, the effect of stimulating milk secretion of stimulating the menstrual flow.Cure mainly: for stranguria, edema, vexed dark coloured urine, aphtha of the mouth and tongue, amenorrhea breast is few, damp and hot arthralgia pain.
Flos Lonicerae: modern study proves, Flos Lonicerae contains the pharmacological component such as chlorogenic acid, luteolin glycosides, stronger restraint is had to the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc., in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary, hypertension etc. more than 40 with other medicines compatibility and plant disease.
Fructus Forsythiae: function cures mainly: heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.
The present composition can alleviate deaf principle based on Chinese medicine, and the Chinese medicinal material selected all has heat-clearing and toxic substances removing, controls effect of deafness, tinnitus, and cheap, and life-time service also can not cause the financial burden of patient, is to alleviate deaf ideal medicine.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1alleviate a deaf compositions, get following traditional Chinese medicine raw medicine: Cacumen Securinegae Suffruticosae 9 grams, Fructus Ligustri Lucidi 6 grams, Radix Stellariae Yunnanensis 6 grams, Herba Crotalariae Ferrugineae 10 grams, Semen Cuscutae 1.5 grams, Rhizoma Anemones Altaicae 9 grams, Radix Angelicae Sinensis 4.5 grams, Radix Puerariae 3 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Spica Prunellae 6 grams, Caulis Akebiae 3 grams, Flos Lonicerae 5 grams, Fructus Forsythiae 6 grams.
The preparation method of above-mentioned composition, step is:
1. by Cacumen Securinegae Suffruticosae, Fructus Ligustri Lucidi, Radix Stellariae Yunnanensis, Herba Crotalariae Ferrugineae, Semen Cuscutae and Rhizoma Anemones Altaicae mixing, be placed in the warm water of 30 DEG C, repeatedly clean 1 time, be placed on close grenadine cloth, be put in shady and cool ventilation place, ventilate 2 days, mix thoroughly with Chinese liquor and be placed in preheated container, repeatedly stir-fry 5 minutes, dry in the air stand-by to the crisp smalls that grinds to form;
2. Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae are placed in non iron container, add the water being mixed with rice vinegar of Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae gross weight 4 times, intense fire is fried open, and turns 35 minutes at a simmer, leaches medicinal liquid stand-by;
3. by step 1. gained smalls and step 2. gained filtrate mix, decoct while stir into thick paste, thick paste is divided into two, portion white vaseline is mixed thoroughly, obtain external-applied ointment, portion mixes with Mel, and does not stop stirring 2 minutes with waddy, refined honey becomes ball, and after dry under the environment of 50 DEG C, bottling sealing is for subsequent use.
model case onepoplar XX, female, 35 years old, Chiping County, Liaocheng of Shandong Province.Symptom: auris dextra ring, deaf more than 20 skies.Cause left ear sudden deafness because family matters are tired before patient's first quarter moon, accompany left tinnitus, in " drone " sound, gradually transfer high tone tinnitus persistence after 4 days to and exist, companion is dizzy, nonrotary, clear depending on thing, without pain.Internal medicine diagnosis " hypotension " at that time, less effective of taking medicine, once felt sick, non-ejection vomitted 1 time, was gastric content, without heating, flu, also earless trauma history and medication history.Patient's ferritic soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, fatigue and weakness.Check: auris dextra external ear (-), tympanum (-), without red and swollen and tenderness after ear, fistula (-), audition tuning fork: conductance bone conduction all disappears.Red tip of the tongue, white and thin fur, thready and weak pulse.Diagnosis: idiopathic deafness (kidney essense loss type), due to patient home's difficulty, doctor advised resulting composition of the present invention.
Take embodiment 1 gained pill and use embodiment gained ointment, treat ear after 3 days and feel, what energy was slight hears sound, treats after 10 days, slightly can hear the wave mode sound of tuning fork, and when treatment was to the 20th day, tinnitus disappears, and audition is normal.
embodiment 2alleviate a deaf compositions, get following traditional Chinese medicine raw medicine: Cacumen Securinegae Suffruticosae 30 grams, Fructus Ligustri Lucidi 12 grams, Radix Stellariae Yunnanensis 9 grams, Herba Crotalariae Ferrugineae 15 grams, Semen Cuscutae 3 grams, Rhizoma Anemones Altaicae 15 grams, Radix Angelicae Sinensis 9 grams, Radix Puerariae 12 grams, the Rhizoma Atractylodis Macrocephalae 25 grams, Spica Prunellae 9 grams, Caulis Akebiae 9 grams, Flos Lonicerae 15 grams, Fructus Forsythiae 9 grams.
The preparation method of above-mentioned composition, step is:
1. by Cacumen Securinegae Suffruticosae, Fructus Ligustri Lucidi, Radix Stellariae Yunnanensis, Herba Crotalariae Ferrugineae, Semen Cuscutae and Rhizoma Anemones Altaicae mixing, be placed in the warm water of 33 DEG C, repeatedly clean 5 times, be placed on close grenadine cloth, be put in shady and cool ventilation place, ventilate 3 days, mix thoroughly with Chinese liquor and be placed in preheated container, repeatedly stir-fry 15 minutes, dry in the air stand-by to the crisp smalls that grinds to form;
2. Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae are placed in non iron container, add the water being mixed with rice vinegar of Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae gross weight 8 times, intense fire is fried open, and turns 45 minutes at a simmer, leaches medicinal liquid stand-by;
3. by step 1. gained smalls and step 2. gained filtrate mix, decoct while stir into thick paste, thick paste is divided into two, portion white vaseline is mixed thoroughly, obtain external-applied ointment, portion mixes with Mel, and does not stop stirring 6 minutes with waddy, refined honey becomes ball, and after dry under the environment of 60 DEG C, bottling sealing is for subsequent use.
embodiment 3alleviate a deaf compositions, get following traditional Chinese medicine raw medicine: Cacumen Securinegae Suffruticosae 15 grams, Fructus Ligustri Lucidi 7 grams, Radix Stellariae Yunnanensis 7 grams, Herba Crotalariae Ferrugineae 12 grams, Semen Cuscutae 2 grams, Rhizoma Anemones Altaicae 10 grams, Radix Angelicae Sinensis 5 grams, Radix Puerariae 5 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Spica Prunellae 7 grams, Caulis Akebiae 5 grams, Flos Lonicerae 8 grams, Fructus Forsythiae 7 grams.
The preparation method of above-mentioned composition, step is:
1. by Cacumen Securinegae Suffruticosae, Fructus Ligustri Lucidi, Radix Stellariae Yunnanensis, Herba Crotalariae Ferrugineae, Semen Cuscutae and Rhizoma Anemones Altaicae mixing, be placed in the warm water of 33 DEG C, repeatedly clean 2 times, be placed on close grenadine cloth, be put in shady and cool ventilation place, ventilate 3 days, mix thoroughly with Chinese liquor and be placed in preheated container, repeatedly stir-fry 8 minutes, dry in the air stand-by to the crisp smalls that grinds to form;
2. Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae are placed in non iron container, add the water being mixed with rice vinegar of Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae gross weight 5 times, intense fire is fried open, and turns 38 minutes at a simmer, leaches medicinal liquid stand-by;
3. by step 1. gained smalls and step 2. gained filtrate mix, decoct while stir into thick paste, thick paste is divided into two, portion white vaseline is mixed thoroughly, obtain external-applied ointment, portion mixes with Mel, and does not stop stirring 3 minutes with waddy, refined honey becomes ball, and after dry under the environment of 53 DEG C, bottling sealing is for subsequent use.
embodiment 4alleviate a deaf compositions, get following traditional Chinese medicine raw medicine: Cacumen Securinegae Suffruticosae 25 grams, Fructus Ligustri Lucidi 10 grams, Radix Stellariae Yunnanensis 8 grams, Herba Crotalariae Ferrugineae 14 grams, Semen Cuscutae 2.5 grams, Rhizoma Anemones Altaicae 13 grams, Radix Angelicae Sinensis 8 grams, Radix Puerariae 10 grams, the Rhizoma Atractylodis Macrocephalae 20 grams, Spica Prunellae 8 grams, Caulis Akebiae 8 grams, Flos Lonicerae 12 grams, Fructus Forsythiae 8 grams.
The preparation method of above-mentioned composition, step is:
1. by Cacumen Securinegae Suffruticosae, Fructus Ligustri Lucidi, Radix Stellariae Yunnanensis, Herba Crotalariae Ferrugineae, Semen Cuscutae and Rhizoma Anemones Altaicae mixing, be placed in the warm water of 38 DEG C, repeatedly clean 4 times, be placed on close grenadine cloth, be put in shady and cool ventilation place, ventilate 5 days, mix thoroughly with Chinese liquor and be placed in preheated container, repeatedly stir-fry 13 minutes, dry in the air stand-by to the crisp smalls that grinds to form;
2. Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae are placed in non iron container, add the water being mixed with rice vinegar of Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae gross weight 7 times, intense fire is fried open, and turns 43 minutes at a simmer, leaches medicinal liquid stand-by;
3. by step 1. gained smalls and step 2. gained filtrate mix, decoct while stir into thick paste, thick paste is divided into two, portion white vaseline is mixed thoroughly, obtain external-applied ointment, portion mixes with Mel, and does not stop stirring 5 minutes with waddy, refined honey becomes ball, and after dry under the environment of 58 DEG C, bottling sealing is for subsequent use.
model case twoopen XX, man, 46 years old, Zichuan District of Zibo City of Shandong Province.Symptom: left tinnitus, deafness more than 1 year.When patient had physical education before 1 year, left Ear Trauma, feels auditory dysesthesia gradually later, and in the ear of left side, song is continuous, by do not subtract, vexed swollen pain in companion's ear, once multi-treatment had no improvement.Check: external auditory meatus and tympanum show no obvious abnormalities, tongue with ecchymosis, stringy and hesitant pulse.Diagnosis: traumatic deafness (obstruction of collaterals by blood stasis type).
Take embodiment 4 gained pill and use embodiment gained ointment, treat ear after 3 days and feel, what energy was slight hears sound, treats after 15 days, slightly can hear the wave mode sound of tuning fork, and when treatment was to the 21st day, tinnitus disappears, and audition is normal.
embodiment 5alleviate a deaf compositions, get following traditional Chinese medicine raw medicine: Cacumen Securinegae Suffruticosae 20 grams, Fructus Ligustri Lucidi 8 grams, Radix Stellariae Yunnanensis 7.5 grams, Herba Crotalariae Ferrugineae 13 grams, Semen Cuscutae 2.2 grams, Rhizoma Anemones Altaicae 11 grams, Radix Angelicae Sinensis 6 grams, Radix Puerariae 7 grams, the Rhizoma Atractylodis Macrocephalae 18 grams, Spica Prunellae 7.5 grams, Caulis Akebiae 6 grams, Flos Lonicerae 9 grams.
The preparation method of above-mentioned composition, step is:
1. by Cacumen Securinegae Suffruticosae, Fructus Ligustri Lucidi, Radix Stellariae Yunnanensis, Herba Crotalariae Ferrugineae, Semen Cuscutae and Rhizoma Anemones Altaicae mixing, be placed in the warm water of 35 DEG C, repeatedly clean 3 times, be placed on close grenadine cloth, be put in shady and cool ventilation place, ventilate 4 days, mix thoroughly with Chinese liquor and be placed in preheated container, repeatedly stir-fry 10 minutes, dry in the air stand-by to the crisp smalls that grinds to form;
2. Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae are placed in non iron container, add the water being mixed with rice vinegar of Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae gross weight 6 times, intense fire is fried open, and turns 40 minutes at a simmer, leaches medicinal liquid stand-by;
3. by step 1. gained smalls and step 2. gained filtrate mix, decoct while stir into thick paste, thick paste is divided into two, portion white vaseline is mixed thoroughly, obtain external-applied ointment, portion mixes with Mel, and does not stop stirring 4 minutes with waddy, refined honey becomes ball, and after dry under the environment of 55 DEG C, bottling sealing is for subsequent use.
experimental examplein order to verify the effect of the present composition, We conducted the experiment (embodiment 5) of medicine, and accurately statistics and mathematical analysis having been carried out to data.Specific experiment result is as following table:
Table 1:
Prove through clinical trial, the present composition can alleviated in deafness, and effective percentage is 99%, and cure rate is 95%, and exceed 9% than the Western medicine effective percentage of oral medication deafness, cure rate exceeds 70%, and thoroughly can remove old complaint, makes the recovery from illness that patient is real; Can alleviate deaf Chinese medicine effective percentage than other oral classes and exceed 14%, cure rate is high by 25%, and can not cause any burden to the health of patient.Present composition instant effect, can reach the object alleviating rapidly patient's misery, and relapse rate is low, is a kind of compositions can alleviating deafness safely and effectively.
Claims (10)
1. can alleviate a deaf compositions, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Cacumen Securinegae Suffruticosae 9-30 part, Fructus Ligustri Lucidi 6-12 part, Radix Stellariae Yunnanensis 6-9 part, Herba Crotalariae Ferrugineae 10-15 part, Semen Cuscutae 1.5-3 part, Rhizoma Anemones Altaicae 9-15 part, Radix Angelicae Sinensis 4.5-9 part, Radix Puerariae 3-12 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Spica Prunellae 6-9 part, Caulis Akebiae 3-9 part, Flos Lonicerae 5-15 part, Fructus Forsythiae 6-9 part.
2. can alleviate deaf compositions according to claim 1, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Cacumen Securinegae Suffruticosae 15-25 part, Fructus Ligustri Lucidi 7-10 part, Radix Stellariae Yunnanensis 7-8 part, Herba Crotalariae Ferrugineae 12-14 part, Semen Cuscutae 2-2.5 part, Rhizoma Anemones Altaicae 10-13 part, Radix Angelicae Sinensis 5-8 part, Radix Puerariae 5-10 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Spica Prunellae 7-8 part, Caulis Akebiae 5-8 part, Flos Lonicerae 8-12 part, Fructus Forsythiae 7-8 part.
3. can alleviate deaf compositions according to claim 1, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Cacumen Securinegae Suffruticosae 20 parts, Fructus Ligustri Lucidi 8 parts, Radix Stellariae Yunnanensis 7.5 parts, Herba Crotalariae Ferrugineae 13 parts, Semen Cuscutae 2.2 parts, Rhizoma Anemones Altaicae 11 parts, Radix Angelicae Sinensis 6 parts, Radix Puerariae 7 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Spica Prunellae 7.5 parts, Caulis Akebiae 6 parts, Flos Lonicerae 9 parts, Fructus Forsythiae 7.5 parts.
4. the preparation method of the compositions of the deafness alleviated according to any one of claim 1-3, is characterized in that: step is as follows:
1. by Cacumen Securinegae Suffruticosae, Fructus Ligustri Lucidi, Radix Stellariae Yunnanensis, Herba Crotalariae Ferrugineae, Semen Cuscutae and Rhizoma Anemones Altaicae mixing, be placed in the warm water of 30-40 DEG C, repeatedly clean 1-5 time, be placed on close grenadine cloth, be put in shady and cool ventilation place, ventilation 2-6 days, mix thoroughly with Chinese liquor and be placed in preheated container, stir-fry 5-15 minute repeatedly, dries in the air stand-by to the crisp smalls that grinds to form;
2. Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae are placed in non iron container, add Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and the Fructus Forsythiae gross weight 4-8 water being mixed with rice vinegar doubly, intense fire is fried open, turn 35-45 minute at a simmer, leach medicinal liquid stand-by;
3. by step 1. gained smalls and step 2. gained filtrate mix, decoct while stir into thick paste, thick paste is divided into two, portion white vaseline is mixed thoroughly, obtain external-applied ointment, portion mixes with Mel, and does not stop to stir 2-6 minute with waddy, refined honey becomes ball, and after dry under the environment of 50-60 DEG C, bottling sealing is for subsequent use.
5. the preparation method of compositions according to claim 4, is characterized in that: 1. step is placed in the warm water of 33-38 DEG C, repeatedly cleans 2-4 all over (be preferably placed in the warm water of 35 DEG C, repeatedly clean 3 times).
6. the preparation method of compositions according to claim 4, is characterized in that: 1. step is put in shady and cool ventilation place, ventilation 3-5 days (be preferably put in shady and cool ventilation place, ventilate 4 days).
7. the preparation method of compositions according to claim 4, it is characterized in that: 1. step is mixed thoroughly with Chinese liquor and be placed in preheated container, stir-fry 8-13 minute (preferably mixing thoroughly with Chinese liquor is placed in preheated container, repeatedly stir-fries 10 minutes) repeatedly.
8. the preparation method of compositions according to claim 4, is characterized in that: 2. step adds Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and the Fructus Forsythiae gross weight 5-7 water (preferably adding the water being mixed with rice vinegar of Radix Angelicae Sinensis, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Spica Prunellae, Caulis Akebiae, Flos Lonicerae and Fructus Forsythiae gross weight 6 times) being mixed with rice vinegar doubly.
9. the preparation method of compositions according to claim 4, is characterized in that: 2. step turns 38-43 at a simmer minute (preferably turning 40 minutes at a simmer).
3. and do not stop to stir 3-5 minute (preferably and do not stop stirring 4 minutes with waddy) with waddy 10. the preparation method of compositions according to claim 4, is characterized in that: step.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228626A (en) * | 2011-06-13 | 2011-11-02 | 郭庆松 | Traditional Chinese medicine for treating tinnitus and deafness |
| CN104435592A (en) * | 2014-10-31 | 2015-03-25 | 王运华 | Traditional Chinese medicine for treating sudden sensor neural hearing loss and tinnitus and preparation method thereof |
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2015
- 2015-11-10 CN CN201510758561.2A patent/CN105326917A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228626A (en) * | 2011-06-13 | 2011-11-02 | 郭庆松 | Traditional Chinese medicine for treating tinnitus and deafness |
| CN104435592A (en) * | 2014-10-31 | 2015-03-25 | 王运华 | Traditional Chinese medicine for treating sudden sensor neural hearing loss and tinnitus and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王章等: "中药治疗突发性耳聋的应用进展", 《海峡药学》 * |
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Application publication date: 20160217 |