CN105315380A - Volvariella volvacea polysaccharide and application thereof - Google Patents
Volvariella volvacea polysaccharide and application thereof Download PDFInfo
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- CN105315380A CN105315380A CN201410312770.XA CN201410312770A CN105315380A CN 105315380 A CN105315380 A CN 105315380A CN 201410312770 A CN201410312770 A CN 201410312770A CN 105315380 A CN105315380 A CN 105315380A
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Abstract
The invention provides volvariella volvacea polysaccharide and an application thereof. The volvariella volvacea has an excellent moisturizing effect and can be used in the fields of cosmetics, health-caring foods and medicines, especially in cosmetics.
Description
Technical field
The invention belongs to field of natural product chemistry, particularly relate to a kind of straw mushroom polysaccharide and application thereof.
Background technology
The temperature variation that air-conditioning, environmental pollution, Seasonal conversion bring and pressure, and skin aging, metabolism the factor such as to slow down and all can cause skin water loss, make skin coarse, dim mute, form dry line, cause many skin problems.Wetting Agent for Printing Inks plays an important role to maintenance moisture of skin and reparation skin barrier function, is widely used in makeup.
Wetting Agent for Printing Inks kind is a lot, wherein based on polyvalent alcohol, vaseline, as the most conventional in glycerine, silicone oil, Vaseline, white oil, lanolin, urea etc., main drawback is that after using, skin often has greasy feeling, some preparation (as lanolin, urea etc.) has peculiar smell, and some also easily causes allergic etc.And deriving from the material with moisturizing effect of natural phant or composition, to have security high, the advantage such as with low cost, just day by day obtains the attention of skin care industry.
Straw mushroom (Volvariellavolvacea (Bull.exFr.) Sing.), belong to Hymenomycetes (Hymenomycetes), Agaricales (Agricales), Guang Bing mushroom section (Pluteaceae), Volvariella (Volvariella), another name Nanhua mushroom, delicious straw mushroom, delicious luxuriant pin mushroom, Volvariella volvacen, stalk mushroom, numb mushroom and Chinese mushroom etc., because of usually grow humidity rot straw in and gain the name, fecund in Guangdong and Guangxi Provinces, Fujian, Jiangxi, Taiwan.The specifiable kind of Volvariella mainly contains the little mushroom of binding foot (V.argentinaSpeg.) of silver color, the little mushroom of binding foot of filamentary silver (V.bombycina (SchaeffFr) .Sing.), edible little mushroom of binding foot (V.escu/enta (Mass.) Sing.), the little mushroom of binding foot of Lip river husband (V./oveyana (Gill.exBerk.) Sing.), between little mushroom V.media (Schum.:Fr.) Sing. that binds foot of type), tiny mushroom of binding foot (V.parvula (Weinm.) Speg.)), intend the little mushroom of binding foot of bud (V.pseudovolvacea (Berk.etBr) .Sing.), the hair little mushroom of binding foot of handle (V.pubescentipes (Pk.) Sing.), beautiful little mushroom of binding foot (V.speciosa (Fr:Fr.) Sing.), beautiful little mushroom of binding foot glues lid mutation (V.speciosavar.gloiocephala (DC.:Fr.) Sing.), the hair little mushroom of binding foot of holder (V.villosovolva (LLoyd) Sing.), straw mushroom sea nurse mutation (V.volvaceavar.heimiiSing.), straw mushroom horse Sa mutation (V.volvaceavar.masseeiSing.), straw mushroom var. niger (V.volvaceavar.nigricansKawam.).
The merit that straw mushroom is nutritious, delicious flavour, has good health value, records according to classic medical book, and straw mushroom has " heat of dispelling of relieving summer heat, gain is healthy ".Modern medicine is thought, straw mushroom have invigorate the spleen and benefit qi, clearing away summer heat, raising immunizing power, the effect such as antitumor, hypoglycemic, accelerating wound healing.Current straw mushroom be mainly used in edible and medicinal on, there is anti-oxidant, immunity moderation and antitumor action.But the current development arrangement of straw mushroom is low, it is narrow to carry out field, and resource is also underutilized, and its pharmaceutical use, makeup aspect are worth and lack deeply and comprehensively study.At present there are no the report about the moisture-keeping efficacy of straw mushroom polysaccharide and the application in makeup.
Summary of the invention
The object of the invention is to: a kind of straw mushroom polysaccharide and application thereof are provided, be intended to straw mushroom polysaccharide to be applied in external composition for skin, to play the effect of beauty and skin care.
The object of the present invention is achieved like this:
A kind of straw mushroom polysaccharide, wherein total polysaccharides percentage composition is 13.15-14.91.
Described straw mushroom polysaccharide, prepare by the following method:
After being pulverized by straw mushroom, add water or organic solvent extraction, filter, by filtrate except concentrated after desolventizing, add organic solvent deposit, filter, filter residue organic solvent repeatedly washing precipitation, obtains straw mushroom polysaccharide.
Described organic solvent refers to the organic solvent containing hydroxyl or carbonyl isopolarity group, such as: methane amide, dimethyl formamide, hexamethylphosphoramide, Tetramethyl Ethylene Diamine, triethylamine, Tributylamine, acetic acid, trifluoroacetic acid, acetonitrile, methyl-formiate, ethyl acetate, methylcarbonate, methyl-sulphoxide, acetone, methylethylketone, dioxane, pyridine, tetrahydrofuran (THF), methyl alcohol, ethanol, trichloromethane, glycerol, propylene glycol, propylene glycol, Virahol, propyl carbinol and ether etc., in one or more, the wherein preferred alcohol aqueous solution.
When taking aqueous ethanolic solution as organic solvent, the concentration of ethanol selects 60-99%.
Known according to test, straw mushroom polysaccharide has good effect in moisturizing, can add in cosmetic formulations as activeconstituents, and the activeconstituents of indication can provide one or more effect in some cases here.
Activeconstituents described in the present invention can also be panthenol, Rizinsan K2 A2, wallantoin, niacinamide, NAP, wild pansy extract, hyaluronate sodium, VITAMIN E ACETATE, undecylenoyl phenylalanine etc.In addition, this type of describes is for the ease of understanding, and is not the application or listed application that composition are limited to specifically note.
Straw mushroom polysaccharide can be applicable to external composition for skin, protective foods and medicine, especially can be applicable in makeup, the consumption different according to the dissimilar interpolation of preparation.
Described Dermatologic preparation composition is the general designation concept of all the components being generally used for skin outside, such as, can be cosmetic combination or pharmaceutical compositions.Can be foundation make up material, facial dressing cosmetic preparation, health cosmetic preparation, hair nursing cosmetic preparation etc. in described cosmetic combination, to its formulation without particular restriction, can choose reasonable according to different object.
According to the medium difference also allowed containing different cosmeceutical aspects of formulation and object or matrix excipients in described cosmetic combination.
May be used for the makeup of Dermatologic preparation composition of the present invention, dermatology or pharmaceutically acceptable vehicle can be the form of aqueous phase, oil phase, gel, water bag wax pattern emulsion, emulsion oil-in-water or water-in-oil emulsion.Aqueous phase is the mixture of one or more water-soluble or dispersed components, and it can be at room temperature liquid, semisolid or solid.It can be maybe the form of suspension, dispersion liquid or the solution in water or water-ol vehicle that vehicle comprises, and it can contain thickening material or gelifying agent.The product form that the knowledge-chosen that those skilled in the art can grasp based on those skilled in the art is suitable, the component wherein comprised.
Described composition can comprise aqueous phase, this aqueous phase can contain the mixture of water or water and at least one hydrophilic organic solvent, described hydrophilic organic solvent such as alcohol, the straight or branched low-grade monobasic alcohol especially containing 2-5 carbon atom, as ethanol or propyl alcohol; Polyvalent alcohol, as propylene glycol, sorbyl alcohol, glycerine, panthenol or polyoxyethylene glycol and composition thereof.
When inventive composition is emulsion form, said composition optionally can also comprise tensio-active agent.
Described composition can also comprise film-forming polymer, as polyurethane(s), polyacrylic acid homopolymer or multipolymer, polyester, based on the resin of hydrocarbon and/or silicone resin.Polymkeric substance can be dissolved in or to be scattered in the acceptable vehicle of makeup and optional and softening agent merges.
Composition of the present invention can also comprise oil phase, and described oil phase contains at room temperature for the oil soluble of liquid or oil-dispersing property component and/or be at room temperature oily or wax-like material, as wax, semisolid, natural gum and composition thereof.This oil phase can also contain organic solvent.
Usually be at room temperature liquid, suitable oily matter comprises: the oil based on hydrocarbon deriving from animal, as perhydrosqualene; Based on the vegetables oil of hydrocarbon, as the C of liquid
4-10the triglyceride of lipid acid, such as enanthic acid or Trivent OCG class, or oil, such as sunflower oil, Semen Maydis oil, soybean oil, raisin seed oil, Viscotrol C, Lipoval A, caprylic/capric triglyceride class, Jojoba oil; The straight or branched hydro carbons in mineral or synthesis source, such as liquid paraffin and its derivant, Vaseline; The ester class of synthesizing ester and ethers, particularly fatty alcohol, such as Isopropyl myristate, palmitinic acid 2-ethylhexyl, stearic acid 2-octyldodecyl, isostearyl isostearate ester; Hydroxylation ester class, the heptanoate class of such as lactic acid isooctadecanol ester, octyl hydroxystearate, octyl hydroxystearate, oxystearic acid octyldodecyl, fatty alcohol, octanoate class and capric acid lipid; Polyol ester class, such as propylene, neopentyl glycol two heptanoate, the different pelargonate of glycol ether two and pentaerythritol esters; Containing C
12-26aliphatic alcohols, such as Standamul G, 2-butyl octanol, 2-hexyl decyl alcohol, 2-undecylpentadecanol, oleyl alcohol; Based on fluorocarbon oil and/or the fluorosilicon oil of part hydrocarbon, silicone oil, be at room temperature liquid or semisolid volatility or nonvolatile straight chain or cyclo-methicone, such as X 2-1401 and polydimethylsiloxane, it optionally comprises phenyl, such as Silicone DC 556, siloxanes and composition thereof.
Composition of the present invention can comprise any component be usually used in cosmetic field further.These components comprise sanitas, water phase thickener (polysaccharide biological polymer, synthetic polymer) and fatty phase thickening material, perfume compound, wetting ability and lipophilic active agent and composition thereof.
Composition of the present invention can also comprise other Particle Phase, and described Particle Phase can be the pigment and/or pearling agent and/or weighting agent that use in make-up composition.
Pigment may reside in composition, and suitable mineral dye comprises titanium oxide, zirconium white and cerium oxide and zinc oxide, ferric oxide and barba hispanica; Suitable pigment dyestuff comprises barium, strontium, calcium and aluminium color lake and carbon black.
Pearling agent may reside in composition, and suitable pearling agent comprises the mica being coated with titanium oxide, ferric oxide or natural pigment.
Weighting agent may reside in composition, suitable weighting agent comprises talcum powder, silicon-dioxide, Zinic stearas, mica, kaolin, nylon powder, polyethylene powders, Teflon, starch, boron nitride, copolymer microsphere, such as silicone resin microballon.
The oil phase of the present composition can comprise one or more waxes, natural gum or its mixture.Wax comprises based on the wax of hydrocarbon, fluorine wax and/or siloxane wax, and can derive from plant, mineral, animal and/or synthesis source.Suitable wax comprises beeswax, carnauba wax, gama wax, paraffin, Microcrystalline Wax, ceresine; Synthetic wax comprises polyethylene wax, containing C
16-45siloxane wax.Natural gum is generally polydimethylsiloxane or Xylo-Mucine or polyose, and semi-solid material is generally the compound based on hydrocarbon, as lanolin and derivative thereof.
Composition of the present invention can be mixed with any suitable product form.This kind of product form includes, but are not limited to aerosol spray, creme, emulsion, solid, liquid, dispersion, foam, gel, astringent, mousse, ointment, pulvis, patch, brilliantine, solution, hand by pump-type sprays, club, facial mask and hygenic towelette.Can using composition of the present invention by various method well-known in the art expediently for the preparation of or as makeup, dermatology or medicine topical application product.
Dermatologic preparation composition of the present invention can comprise one or more following ingredients: anti-allergic agent, biocide, antioxidant, sequestrant, tinting material depigmentation, softener, emulsifying agent, exfoliation agent, membrane-forming agent, spices, wetting Agent for Printing Inks, insect repellent, lubricant, pharmaceutically active agents, moistening agent, photostabilizer, sanitas, skin-protecting agent, skin penetration enhancer, sun-screening agent, stablizer, tensio-active agent, thickening material, viscosity modifier, VITAMIN or its arbitrary combination.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
The preparation of straw mushroom polysaccharide
Embodiment 1: take the fresh straw mushroom of 120g, after pulverizing, add 10 times of volume water, supersound extraction 2 hours, concentrates filtrate except after desolventizing after filtration, concentrated solution is added alcohol settling, after filtration, filter residue uses 95% ethanol and absolute ethanol washing (also can wash successively with 85% ethanol, 95% ethanol, dehydrated alcohol, acetone, ether) successively, and vacuum-drying, obtains straw mushroom polysaccharide 2.0g.
Embodiment 2: take the fresh straw mushroom of 120g, after pulverizing, adds 10 times of volume water, decoct extraction 2 times, each 2 hours, merging filtrate after filtering, by filtrate except concentrated after desolventizing, concentrated solution is added alcohol settling, after filtration, filter residue is with the repeatedly washing precipitation of 95% ethanol (also can use absolute ethanol washing, or wash successively with 85% ethanol, 95% ethanol, dehydrated alcohol, acetone, ether), vacuum-drying, obtains straw mushroom polysaccharide 2.4g.
Embodiment 3: take the fresh straw mushroom of 120g, after pulverizing, adds 20 times of volume water, supersound extraction 2 times, each 2 hours, merging filtrate after filtering, by filtrate except concentrated after desolventizing, concentrated solution is added alcohol settling, after filtration, filter residue is with the repeatedly washing precipitation of 95% ethanol (also can use absolute ethanol washing, or wash successively with 85% ethanol, 95% ethanol, dehydrated alcohol, acetone, ether), vacuum-drying, obtains straw mushroom polysaccharide 2.1g.
Embodiment 4: the detection of straw mushroom polysaccharide content
Get the polysaccharide that above-described embodiment 1,2,3 is prepared respectively, adopt Phenol-sulphate acid method to carry out total polysaccharides assay.
Detecting step is: 1) standard curve making gets dextrose anhydrous reference substance in right amount, precise weighing, adds water and makes the solution of every 1ml containing dextrose anhydrous 0.6mg.Precision measures reference substance solution 1.0ml, 1.5ml, 2.0ml, 2.5ml, 3.0ml, puts respectively in 50ml volumetric flask, adds water to scale, shake up.Precision measures above-mentioned reference substance solution 2ml, puts in tool plug test tube, adds 4% phenol solution 1ml respectively, mixing, adds rapidly sulfuric acid 7.0ml, shakes up, in 40 DEG C of water-baths, be incubated 30 minutes, take out, to put in ice-water bath 5 minutes, taking out, is blank with corresponding reagent, according to ultraviolet visible spectrophotometry, absorbancy is measured at the wavelength place of 490nm, take absorbancy as ordinate zou, concentration is X-coordinate, drawing standard curve.
2) mensuration gets appropriate straw mushroom Crude polysaccharides, precise weighing, puts in 50ml volumetric flask, and is diluted to scale, shake up.Precision measures 2ml, according to the method for standard curve making, from " adding 4% phenol solution 1ml ", measures absorbancy in accordance with the law, reads the weight (mg) of dextrose anhydrous in need testing solution from typical curve.
In straw mushroom polysaccharide in measurement result display embodiment 1, total polysaccharides content is 14.59%, and in embodiment 2, total polysaccharides content is 13.15%, and in embodiment 3, total polysaccharides content is 14.91%.
Embodiment 5: the moisturizing determination of activity of straw mushroom polysaccharide
Test sample: get the polysaccharide that above-described embodiment 1,2,3 is prepared respectively respectively, be mixed with 2.5% (w/v) solution with deionized water.
Control sample: deionized water, 2.5% glycerine.
Testing method: measure its moisturizing by external moisturizing method of weighing active, select the slide glass of same specification, one deck medical air-permeable adhesive tape is pasted above, draw each test sample 50 μ L under room temperature condition, even application, on breathable adhesive tape, is then placed in the moisture eliminator drying that relative humidity is 60% (Potassium ethanoate saturated solution), the minimizing of sample quality is weighed after 24 hours, replicate(determination) three times, averages, and calculates the moisturizing rate of sample.
Sample quality * 100% before moisturizing rate (%)=sample quality/placement of placement after 24 hours
Test result is as shown in table 1:
Table 1
| Sample ID | 24 hours moisturizing rates (%) |
| Straw mushroom polysaccharide solution (embodiment 1) | 4.24 |
| Straw mushroom polysaccharide solution (embodiment 2) | 4.07 |
| Straw mushroom polysaccharide solution (embodiment 3) | 4.31 |
| Deionized water | 2.59 |
| 2.5% glycerine | 3.26 |
As seen from the above table, the humidity-holding effect of straw mushroom polysaccharide in 24 hours is better than glycerine, and the moisturizing activity of the straw mushroom polysaccharide prepared according to method in embodiment 3 is best.
Embodiment 6: the external composition for skin containing straw mushroom polysaccharide
The straw mushroom polysaccharide prepared in Example 1,2 and 3, for the preparation of external composition for skin.Described external composition for skin is preferably make-up composition, such as astringent, essence, breast frost etc.The weight percent of described straw mushroom polysaccharide in external composition for skin is 0.1-10, preferred 1-10.It is below the embodiment of the embody rule of straw mushroom polysaccharide in external composition for skin.
In following table, "-" indicates without interpolation.
Embodiment 7: the astringent containing straw mushroom polysaccharide
Get straw mushroom polysaccharide, for the preparation of the astringent with moisture-keeping function, the component that described astringent contains is as shown in table 2:
Table 2
Embodiment 8: the essence containing straw mushroom polysaccharide
Get straw mushroom polysaccharide, for the preparation of the essence with moisture-keeping function, the component that described essence contains is as shown in table 3:
Table 3
Embodiment 9: the emulsion/frost containing straw mushroom polysaccharide
Get straw mushroom polysaccharide, for the preparation of the emulsion/frost with moisture-keeping function, the component that described emulsion/frost contains is as shown in table 4:
Table 4
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. a straw mushroom polysaccharide, is characterized in that, in described straw mushroom polysaccharide, total polysaccharides percentage composition is 13.15-14.91.
2. straw mushroom polysaccharide as claimed in claim 1, is characterized in that, prepares by the following method:
After being pulverized by straw mushroom, add water or organic solvent extraction, filter, by filtrate except concentrated after desolventizing, add organic solvent deposit, filter, filter residue organic solvent repeatedly washing precipitation, obtains straw mushroom polysaccharide.
3. straw mushroom polysaccharide as claimed in claim 2, it is characterized in that, described by after straw mushroom pulverizing, add water or organic solvent extraction is specially, add 10 times of volume water supersound extraction 2 hours, or add 10 times of volume water boiling and extraction 2 times, each 2 hours, or add 20 times of volume water supersound extraction 2 times; Described by filtrate except after concentrated after desolventizing, concentrated solution is added alcohol settling, after filtration, filter residue 95% ethanol repeatedly washing precipitation.
4. the straw mushroom polysaccharide as described in as arbitrary in claim 1-3 has moisture-keeping function.
5. one kind contains the Dermatologic preparation composition of straw mushroom polysaccharide as effective constituent.
6. Dermatologic preparation composition as claimed in claim 5, is characterized in that, described straw mushroom polysaccharide passes through after straw mushroom pulverizing, add water or organic solvent extraction, filter, by filtrate except concentrated after desolventizing, add organic solvent deposit, filter, filter residue organic solvent repeatedly obtains after washing precipitation.
7. Dermatologic preparation composition as claimed in claim 6, it is characterized in that, described by after straw mushroom pulverizing, add water or organic solvent extraction is specially, add 10 times of volume water supersound extraction 2 hours, or add 10 times of volume water boiling and extraction 2 times, each 2 hours, or add 20 times of volume water supersound extraction 2 times; Described by filtrate except after concentrated after desolventizing, concentrated solution is added alcohol settling, after filtration, filter residue 95% ethanol repeatedly washing precipitation.
8. Dermatologic preparation composition as claimed in claims 6 or 7, it is characterized in that, the weight percent of described straw mushroom polysaccharide in Dermatologic preparation composition is 0.1-10.
9. Dermatologic preparation composition as claimed in claim 8, it is characterized in that, the weight percent of described straw mushroom polysaccharide in Dermatologic preparation composition is 1-10.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105943439A (en) * | 2016-06-01 | 2016-09-21 | 合肥丰瑞隆生物科技有限公司 | Straw mushroom mud mask and preparation method thereof |
| CN105963177A (en) * | 2016-05-06 | 2016-09-28 | 福建绿宝食品集团有限公司 | Red blood silk removal facial cream |
| CN105997606A (en) * | 2016-05-06 | 2016-10-12 | 福建绿宝食品集团有限公司 | Body lotion capable of treating keratosis pilaris |
| CN106176399A (en) * | 2016-08-18 | 2016-12-07 | 福建绿宝食品集团有限公司 | A kind of mushroom nutritious hair conditioner |
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- 2014-07-02 CN CN201410312770.XA patent/CN105315380A/en active Pending
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| CN102241784A (en) * | 2010-05-10 | 2011-11-16 | 曹传圣 | Extraction method for preparing polysaccharide from straw mushrooms |
Non-Patent Citations (1)
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963177A (en) * | 2016-05-06 | 2016-09-28 | 福建绿宝食品集团有限公司 | Red blood silk removal facial cream |
| CN105997606A (en) * | 2016-05-06 | 2016-10-12 | 福建绿宝食品集团有限公司 | Body lotion capable of treating keratosis pilaris |
| CN105943439A (en) * | 2016-06-01 | 2016-09-21 | 合肥丰瑞隆生物科技有限公司 | Straw mushroom mud mask and preparation method thereof |
| CN106176399A (en) * | 2016-08-18 | 2016-12-07 | 福建绿宝食品集团有限公司 | A kind of mushroom nutritious hair conditioner |
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Application publication date: 20160210 |