CN105311512A - Medicine for treating onychomycosis - Google Patents
Medicine for treating onychomycosis Download PDFInfo
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- CN105311512A CN105311512A CN201510837277.4A CN201510837277A CN105311512A CN 105311512 A CN105311512 A CN 105311512A CN 201510837277 A CN201510837277 A CN 201510837277A CN 105311512 A CN105311512 A CN 105311512A
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Abstract
The invention provides medicine for treating onychomycosis. The medicine is prepared from daphne genkwa, obtuseleaf erycibe stems, fructus gleditsiae, golden larch bark,rhizoma drynariae, garlic, licorice roots, cirsium bracteiferum, fraxinus ferruginea bark, balanophora polyandra whole-grass, astragatus complanatus seeds, syzygium aromaticum, dandelion,szechwan Chinaberry fruits, garden balsam, radix stemonae, artemisia anomala, atractylodes lancea, folium artemisiae argyi, sophora flavescens, cinnamon, cortex dictamni, broom cypress fruits, dragon's blood, safflower carthamus, realgar and the like. Common Chinese herbal medicine serves as the raw materials of the medicine, the raw materials are wide in source, the medicine formula is scientific and reasonable, all constituents act in a synergistic mode, intractable fungi and bacteria can be killed rapidly, skin infection can be eliminated, and the medicine has the advantages of being quick in effectiveness and good in treatment effect when being used for treating onychomycosis.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of tinea unguium, belong to technical field of Chinese medicines.
Background technology
Tinea unguium, is also called tinea unguium, disease caused under referring to dermatophytes infringement deck or first.Tinea unguium is infected by the fungus-caused first such as dermatophytes, yeast and non-dermatophytes.The medicine of present market treatment tinea unguium is based on Western medicine, and these Western medicine have the shortcomings, particularly some antimycotic Western medicine such as price is high, side effect is large, easily bring drug resistance, have an attack of one's old illness repeatedly, affect the problems such as human endocrine.
Summary of the invention
The technical problem to be solved in the present invention is: provide a kind of medicine for the treatment of tinea unguium, have the advantages such as low price, therapeutic effect is good, toxic and side effects is little.
For solving the problems of the technologies described above, the present invention by the following technical solutions:
The medicine for the treatment of tinea unguium, is obtained by the raw material of following weight parts:
Flos Genkwa 0.3 ~ 0.8 part, Caulis Erycibes 0.1 ~ 0.5 part, Fructus Gleditsiae Abnormalis 0.1 ~ 0.5 part, Cortex Pseudolaricis 0.5 ~ 1 part, hair Rhizoma Zingiberis Recens 1 ~ 5 part, 1 ~ 5 part, Bulbus Allii, 3 ~ 8 parts, Radix Glycyrrhizae, Radix Cirsii Belingshanici 1 ~ 5 part, 1 ~ 5 part, Cortex Fraxini ferrugineae, Cor Gigeriae Galli 71 ~ 5 parts, Semen Astragali Complanati 1 ~ 5 part, Flos Caryophylli 5 ~ 10 parts, Herba Taraxaci 5 ~ 10 parts, CHUANLAZI 5 ~ 10 parts, Flos Impatientis 5 ~ 10 parts, the Radix Stemonae 5 ~ 10 parts, Herba Artemisiae Anomalae 5 ~ 10 parts, Rhizoma Atractylodis 5 ~ 10 parts, Folium Artemisiae Argyi 5 ~ 10 parts, Radix Sophorae Flavescentis 5 ~ 10 parts, Cortex Cinnamomi 5 ~ 10 parts, Cortex Dictamni 10 ~ 15 parts, the Fructus Kochiae 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, Realgar 10 ~ 15 parts.
As preferably, provide a concrete formula here, the weight portion of described raw material is:
Flos Genkwa 0.3 part, Caulis Erycibes 0.3 part, Fructus Gleditsiae Abnormalis 0.5 part, Cortex Pseudolaricis 0.5 part, mao Rhizoma Zingiberis Recens 1 part, 3 parts, Bulbus Allii, 8 parts, Radix Glycyrrhizae, Radix Cirsii Belingshanici 1 part, 3 parts, Cortex Fraxini ferrugineae, Cor Gigeriae Galli 75 parts, Semen Astragali Complanati 1 part, Flos Caryophylli 8 parts, Herba Taraxaci 10 parts, CHUANLAZI 5 parts, Flos Impatientis 7 parts, the Radix Stemonae 5 parts, Herba Artemisiae Anomalae 9 parts, Rhizoma Atractylodis 10 parts, Folium Artemisiae Argyi 5 parts, Radix Sophorae Flavescentis 8 parts, Cortex Cinnamomi 10 parts, Cortex Dictamni 10 parts, the Fructus Kochiae 13 parts, Sanguis Draxonis 15 parts, 10 parts, Flos Carthami, Realgar 11 parts.
As preferably, provide second concrete formula here, the weight portion of described raw material is:
Flos Genkwa 0.5 part, Caulis Erycibes 0.5 part, Fructus Gleditsiae Abnormalis 0.1 part, Cortex Pseudolaricis 0.5 part, mao Rhizoma Zingiberis Recens 2 parts, 5 parts, Bulbus Allii, 3 parts, Radix Glycyrrhizae, Radix Cirsii Belingshanici 2 parts, 5 parts, Cortex Fraxini ferrugineae, Cor Gigeriae Galli 71 parts, Semen Astragali Complanati 3 parts, Flos Caryophylli 10 parts, Herba Taraxaci 5 parts, CHUANLAZI 8 parts, Flos Impatientis 10 parts, the Radix Stemonae 9 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Atractylodis 5 parts, Folium Artemisiae Argyi 7 parts, Radix Sophorae Flavescentis 10 parts, Cortex Cinnamomi 5 parts, Cortex Dictamni 13 parts, the Fructus Kochiae 15 parts, Sanguis Draxonis 10 parts, 13 parts, Flos Carthami, Realgar 15 parts.
As preferably, provide the 3rd concrete formula here, the weight portion of described raw material is:
Flos Genkwa 0.8 part, Caulis Erycibes 0.1 part, Fructus Gleditsiae Abnormalis 0.3 part, Cortex Pseudolaricis 0.8 part, mao Rhizoma Zingiberis Recens 5 parts, 1 part, Bulbus Allii, 5 parts, Radix Glycyrrhizae, Radix Cirsii Belingshanici 5 parts, 1 part, Cortex Fraxini ferrugineae, Cor Gigeriae Galli 73 parts, Semen Astragali Complanati 5 parts, Flos Caryophylli 5 parts, Herba Taraxaci 8 parts, CHUANLAZI 10 parts, Flos Impatientis 5 parts, the Radix Stemonae 7 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Atractylodis 5 parts, Folium Artemisiae Argyi 8 parts, Radix Sophorae Flavescentis 10 parts, Cortex Cinnamomi 5 parts, Cortex Dictamni 13 parts, the Fructus Kochiae 15 parts, Sanguis Draxonis 10 parts, 13 parts, Flos Carthami, Realgar 15 parts.
The present invention also provides the preparation method of said medicine, its step the following is: by Flos Genkwa, Caulis Erycibes, Fructus Gleditsiae Abnormalis, Cortex Pseudolaricis, Mao Jiang, after Bulbus Allii and Radix Glycyrrhizae co-grinding, be first alcohol-pickled 0.1 ~ 0.5 hour of 30% ~ 60% by volumetric concentration, taking-up water rinses, be placed in the water that it soaks front weight 3 ~ 10 times, after being heated to boiling, decoct 0.5 ~ 1 hour under slight boiling condition, filter, filtrate is concentrated into 30% ~ 40% of its volume, add the modified starch of concentrated solution weight 1% ~ 3%, after spraying dry, by the dried powder that obtains and all the other raw material co-grinding to 40 ~ 100 orders, namely this medicine is obtained.
The using method of this medicine is: in Chinese liquor medicine being added its weight 2 ~ 3 times or rice wine, soak after 1 ~ 3 day, and to be steeped in affected part in wine 10 ~ 30 minutes, take out nature and dry, each consumption is 5 ~ 10 grams, within one day, uses 2 ~ 3 times.
The invention has the beneficial effects as follows: raw material of the present invention is conventional Chinese herbal medicine, wide material sources, low price; Pharmaceutical formulation is scientific and reasonable, synergism between each component, can kill rapidly intractable fungus, antibacterial, eliminates skin infection; Through 100 routine experiencer's medications after 30 ~ 60 days, effective or effective 85 examples, and none example occurs uncomfortable waiting side effect, are used for the treatment of tinea unguium and have instant effect, advantage that therapeutic effect is good.
Detailed description of the invention
Further illustrate the present invention by the following examples, but the invention is not restricted to these embodiments.
Embodiment 1
The medicine for the treatment of tinea unguium, is obtained by the raw material of following weight parts: Flos Genkwa 0.3 part, Caulis Erycibes 0.3 part, Fructus Gleditsiae Abnormalis 0.5 part, Cortex Pseudolaricis 0.5 part, mao Rhizoma Zingiberis Recens 1 part, 3 parts, Bulbus Allii, 8 parts, Radix Glycyrrhizae, Radix Cirsii Belingshanici 1 part, 3 parts, Cortex Fraxini ferrugineae, Cor Gigeriae Galli 75 parts, Semen Astragali Complanati 1 part, Flos Caryophylli 8 parts, Herba Taraxaci 10 parts, CHUANLAZI 5 parts, Flos Impatientis 7 parts, the Radix Stemonae 5 parts, Herba Artemisiae Anomalae 9 parts, Rhizoma Atractylodis 10 parts, Folium Artemisiae Argyi 5 parts, Radix Sophorae Flavescentis 8 parts, Cortex Cinnamomi 10 parts, Cortex Dictamni 10 parts, the Fructus Kochiae 13 parts, Sanguis Draxonis 15 parts, 10 parts, Flos Carthami, Realgar 11 parts.
The preparation method of medicine is: after Flos Genkwa, Caulis Erycibes, Fructus Gleditsiae Abnormalis, Cortex Pseudolaricis, Mao Jiang, Bulbus Allii and Radix Glycyrrhizae co-grinding, be first alcohol-pickled 0.3 hour of 30% by volumetric concentration, taking-up water rinses, be placed in the water that it soaks front weight 10 times, after being heated to boiling, decoct 0.5 hour under slight boiling condition, filter, filtrate is concentrated into 35% of its volume, add the modified starch of concentrated solution weight 3%, after spraying dry, by dried powder and all the other raw material co-grinding to 40 orders of obtaining.
Embodiment 2
The medicine for the treatment of tinea unguium, is obtained by the raw material of following weight parts: Flos Genkwa 0.5 part, Caulis Erycibes 0.5 part, Fructus Gleditsiae Abnormalis 0.1 part, Cortex Pseudolaricis 0.5 part, mao Rhizoma Zingiberis Recens 2 parts, 5 parts, Bulbus Allii, 3 parts, Radix Glycyrrhizae, Radix Cirsii Belingshanici 2 parts, 5 parts, Cortex Fraxini ferrugineae, Cor Gigeriae Galli 71 parts, Semen Astragali Complanati 3 parts, Flos Caryophylli 10 parts, Herba Taraxaci 5 parts, CHUANLAZI 8 parts, Flos Impatientis 10 parts, the Radix Stemonae 9 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Atractylodis 5 parts, Folium Artemisiae Argyi 7 parts, Radix Sophorae Flavescentis 10 parts, Cortex Cinnamomi 5 parts, Cortex Dictamni 13 parts, the Fructus Kochiae 15 parts, Sanguis Draxonis 10 parts, 13 parts, Flos Carthami, Realgar 15 parts.
The preparation method of medicine is: after Flos Genkwa, Caulis Erycibes, Fructus Gleditsiae Abnormalis, Cortex Pseudolaricis, Mao Jiang, Bulbus Allii and Radix Glycyrrhizae co-grinding, be first alcohol-pickled 0.1 hour of 60% by volumetric concentration, taking-up water rinses, be placed in the water that it soaks front weight 3 times, after being heated to boiling, decoct 0.8 hour under slight boiling condition, filter, filtrate is concentrated into 40% of its volume, add the modified starch of concentrated solution weight 1%, after spraying dry, by dried powder and all the other raw material co-grinding to 100 orders of obtaining.
Embodiment 3
The medicine for the treatment of tinea unguium, is obtained by the raw material of following weight parts: Flos Genkwa 0.8 part, Caulis Erycibes 0.1 part, Fructus Gleditsiae Abnormalis 0.3 part, Cortex Pseudolaricis 0.8 part, mao Rhizoma Zingiberis Recens 5 parts, 1 part, Bulbus Allii, 5 parts, Radix Glycyrrhizae, Radix Cirsii Belingshanici 5 parts, 1 part, Cortex Fraxini ferrugineae, Cor Gigeriae Galli 73 parts, Semen Astragali Complanati 5 parts, Flos Caryophylli 5 parts, Herba Taraxaci 8 parts, CHUANLAZI 10 parts, Flos Impatientis 5 parts, the Radix Stemonae 7 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Atractylodis 5 parts, Folium Artemisiae Argyi 8 parts, Radix Sophorae Flavescentis 10 parts, Cortex Cinnamomi 5 parts, Cortex Dictamni 13 parts, the Fructus Kochiae 15 parts, Sanguis Draxonis 10 parts, 13 parts, Flos Carthami, Realgar 15 parts.
The preparation method of medicine is: after Flos Genkwa, Caulis Erycibes, Fructus Gleditsiae Abnormalis, Cortex Pseudolaricis, Mao Jiang, Bulbus Allii and Radix Glycyrrhizae co-grinding, be first alcohol-pickled 0.5 hour of 40% by volumetric concentration, taking-up water rinses, be placed in the water that it soaks front weight 8 times, after being heated to boiling, decoct 1 hour under slight boiling condition, filter, filtrate is concentrated into 30% of its volume, add the modified starch of concentrated solution weight 2%, after spraying dry, by dried powder and all the other raw material co-grinding to 60 orders of obtaining.
Toxicity test
Get ICR mice, before experiment, water 15h is can't help in fasting, is divided into 19 groups (the trial drug group of each embodiment 6 groups, matched groups 1 group).Each group of mouse tail vein administration, test 1 group and be all according to dosage respectively 500mg/kg, 1000mg/kg, 2000mg/kg, 5000mg/kg, 10000mg/kg, 20000mg/kg to test 6 groups of dosages, control group mice gives same volume distilled water.Examine and record administration at once to toxic reaction and the death condition of mice appearance in 7d; Bliss ' s method is adopted to calculate LD50.The following form of experimental result:
| Group | mg/kg |
| Embodiment 1 medicine | 3724.42 |
| Embodiment 2 medicine | 3759.34 |
| Embodiment 3 medicine | 3670.99 |
The LD50 of medicine is at more than 3670mg/kg as seen from the above table, and obviously the toxicity of this medicine is very low, and is external use, in the rational scope of application, few to the toxic and side effects of human body.
Claims (5)
1. treat the medicine of tinea unguium, it is characterized in that, obtained by the raw material of following weight parts: Flos Genkwa 0.3 ~ 0.8 part, Caulis Erycibes 0.1 ~ 0.5 part, Fructus Gleditsiae Abnormalis 0.1 ~ 0.5 part, Cortex Pseudolaricis 0.5 ~ 1 part, hair Rhizoma Zingiberis Recens 1 ~ 5 part, 1 ~ 5 part, Bulbus Allii, 3 ~ 8 parts, Radix Glycyrrhizae, Radix Cirsii Belingshanici 1 ~ 5 part, 1 ~ 5 part, Cortex Fraxini ferrugineae, Cor Gigeriae Galli 71 ~ 5 parts, Semen Astragali Complanati 1 ~ 5 part, Flos Caryophylli 5 ~ 10 parts, Herba Taraxaci 5 ~ 10 parts, CHUANLAZI 5 ~ 10 parts, Flos Impatientis 5 ~ 10 parts, the Radix Stemonae 5 ~ 10 parts, Herba Artemisiae Anomalae 5 ~ 10 parts, Rhizoma Atractylodis 5 ~ 10 parts, Folium Artemisiae Argyi 5 ~ 10 parts, Radix Sophorae Flavescentis 5 ~ 10 parts, Cortex Cinnamomi 5 ~ 10 parts, Cortex Dictamni 10 ~ 15 parts, the Fructus Kochiae 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, Realgar 10 ~ 15 parts.
2. medicine according to claim 1, it is characterized in that, the weight portion of described raw material is: Flos Genkwa 0.3 part, Caulis Erycibes 0.3 part, Fructus Gleditsiae Abnormalis 0.5 part, Cortex Pseudolaricis 0.5 part, mao Rhizoma Zingiberis Recens 1 part, 3 parts, Bulbus Allii, 8 parts, Radix Glycyrrhizae, Radix Cirsii Belingshanici 1 part, 3 parts, Cortex Fraxini ferrugineae, Cor Gigeriae Galli 75 parts, Semen Astragali Complanati 1 part, Flos Caryophylli 8 parts, Herba Taraxaci 10 parts, CHUANLAZI 5 parts, Flos Impatientis 7 parts, the Radix Stemonae 5 parts, Herba Artemisiae Anomalae 9 parts, Rhizoma Atractylodis 10 parts, Folium Artemisiae Argyi 5 parts, Radix Sophorae Flavescentis 8 parts, Cortex Cinnamomi 10 parts, Cortex Dictamni 10 parts, the Fructus Kochiae 13 parts, Sanguis Draxonis 15 parts, 10 parts, Flos Carthami, Realgar 11 parts.
3. medicine according to claim 1, it is characterized in that, the weight portion of described raw material is: Flos Genkwa 0.5 part, Caulis Erycibes 0.5 part, Fructus Gleditsiae Abnormalis 0.1 part, Cortex Pseudolaricis 0.5 part, mao Rhizoma Zingiberis Recens 2 parts, 5 parts, Bulbus Allii, 3 parts, Radix Glycyrrhizae, Radix Cirsii Belingshanici 2 parts, 5 parts, Cortex Fraxini ferrugineae, Cor Gigeriae Galli 71 parts, Semen Astragali Complanati 3 parts, Flos Caryophylli 10 parts, Herba Taraxaci 5 parts, CHUANLAZI 8 parts, Flos Impatientis 10 parts, the Radix Stemonae 9 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Atractylodis 5 parts, Folium Artemisiae Argyi 7 parts, Radix Sophorae Flavescentis 10 parts, Cortex Cinnamomi 5 parts, Cortex Dictamni 13 parts, the Fructus Kochiae 15 parts, Sanguis Draxonis 10 parts, 13 parts, Flos Carthami, Realgar 15 parts.
4. medicine according to claim 1, it is characterized in that, the weight portion of described raw material is: Flos Genkwa 0.8 part, Caulis Erycibes 0.1 part, Fructus Gleditsiae Abnormalis 0.3 part, Cortex Pseudolaricis 0.8 part, mao Rhizoma Zingiberis Recens 5 parts, 1 part, Bulbus Allii, 5 parts, Radix Glycyrrhizae, Radix Cirsii Belingshanici 5 parts, 1 part, Cortex Fraxini ferrugineae, Cor Gigeriae Galli 73 parts, Semen Astragali Complanati 5 parts, Flos Caryophylli 5 parts, Herba Taraxaci 8 parts, CHUANLAZI 10 parts, Flos Impatientis 5 parts, the Radix Stemonae 7 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Atractylodis 5 parts, Folium Artemisiae Argyi 8 parts, Radix Sophorae Flavescentis 10 parts, Cortex Cinnamomi 5 parts, Cortex Dictamni 13 parts, the Fructus Kochiae 15 parts, Sanguis Draxonis 10 parts, 13 parts, Flos Carthami, Realgar 15 parts.
5. the medicine according to any one of Claims 1 to 4, it is characterized in that, the preparation method of medicine is: by Flos Genkwa, Caulis Erycibes, Fructus Gleditsiae Abnormalis, Cortex Pseudolaricis, Mao Jiang, after Bulbus Allii and Radix Glycyrrhizae co-grinding, be first alcohol-pickled 0.1 ~ 0.5 hour of 30% ~ 60% by volumetric concentration, taking-up water rinses, be placed in the water that it soaks front weight 3 ~ 10 times, after being heated to boiling, decoct 0.5 ~ 1 hour under slight boiling condition, filter, filtrate is concentrated into 30% ~ 40% of its volume, add the modified starch of concentrated solution weight 1% ~ 3%, after spraying dry, by the dried powder that obtains and all the other raw material co-grinding to 40 ~ 100 orders, namely this medicine is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510837277.4A CN105311512A (en) | 2015-11-27 | 2015-11-27 | Medicine for treating onychomycosis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510837277.4A CN105311512A (en) | 2015-11-27 | 2015-11-27 | Medicine for treating onychomycosis |
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| CN105311512A true CN105311512A (en) | 2016-02-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510837277.4A Pending CN105311512A (en) | 2015-11-27 | 2015-11-27 | Medicine for treating onychomycosis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434312A (en) * | 2018-06-15 | 2018-08-24 | 张生 | It is a kind of to be used to treat liniment of onychomycosis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940765A (en) * | 2015-07-02 | 2015-09-30 | 李清强 | Externally-applied traditional Chinese medicine for treating leuconychia |
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- 2015-11-27 CN CN201510837277.4A patent/CN105311512A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940765A (en) * | 2015-07-02 | 2015-09-30 | 李清强 | Externally-applied traditional Chinese medicine for treating leuconychia |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434312A (en) * | 2018-06-15 | 2018-08-24 | 张生 | It is a kind of to be used to treat liniment of onychomycosis and preparation method thereof |
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Application publication date: 20160210 |