CN105311354A - Traditional Chinese medicinal composition containing folium artemisiae argyi for treating infantile asthma and preparation method of traditional Chinese medicinal composition - Google Patents

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicinal composition containing folium artemisiae argyi for treating infantile asthma and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition is prepared from the following raw materials in parts by weight: 18-30 parts of flos farfarae, 16-28 parts of eucommia ulmoides, 10-18 parts of semen brassicae, 12-28 parts of folium artemisiae argyi, 14-22 parts of lucid ganoderma, 4-10 parts of pericarpium citri reticulatae, 8-16 parts of radix asteris, 2-10 parts of Chinese yam, 2-6 parts of wheatgrass, 2-10 parts of tendril-leaved fritillary bulb, 2-10 parts of rhopilema esculentum, and 4-12 parts of licorice root. The traditional Chinese medicinal composition has the efficacies of sweating and dispelling cold, freeing lung and relieving asthma, expelling phlegm to arrest coughing, soothing the liver to relieve stagnant Qi, as well as clearing heat and moistening lung, and has the advantages of simple preparation technology, good curative effects, small side effects, convenience in taking, and simplicity in popularization and application.

Description

A kind of Chinese medicine composition containing Folium Artemisiae Argyi for the treatment of infantile asthma and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, particularly relate to a kind of Chinese medicine composition containing Folium Artemisiae Argyi for the treatment of infantile asthma and preparation method thereof.

Background technology

The commonly encountered diseases childhood period that infantile asthma being and frequently-occurring disease are the chronic ill reactive disorders of air flue participated in by the inflammation cells such as eosinophilic granulocyte, mastocyte and T lymphocyte and cytokine.Its symptom is: rapid breathing, and suddenly, uncomfortable in chest rough, larynx has asked wheezing sound in outbreak, must not pant put down sleeping.The general outbreak in paroxysmal, or occur agitation, perspiration, expectoration, livid purple, pale complexion, weigh the then symptom such as obnubilation.This onste has obvious seasonality, based on winter and temperature outbreak in changeable season, the age with 1-6 year common.The predisposing factors of 95% is respiratory tract infection, and morbidity has obvious genetic predisposition, works early genetic predisposition of recovering more obvious.The existing endogenous cause of ill of infantile asthma pathogenic factor, has exopathogenic factor again.Lying prostrate in phlegm retention of endogenous cause of ill duty, dirty relevant with lung spleen kidney three, exopathogenic factor is mainly being invaded by exogenous pathogen, contact unusual pathogen.Children's's lungs are tender and lovely, the spleen tending to insufficiency usually, the kidney being always deficient.It is solid that the deficiency of the lung then defends outer mistake, interspaces of skin and muscles being loose, easily by exopathogen is invaded, and evil resistance lung network, disorder of QI movement, body fluid cohesion is expectorant; The spleen has the function to transport and transform nutrients essence of water and grain, spleen insufficiency, rawly wetly makes expectorant, above stores in lung; Kidney qi is weak, can not evaporate water liquid and be Tianjin clearly, upper general be expectorant, poly-liquid becomes to drink.Phlegm retention stays volt relevant with the dirty malfunction of lung spleen kidney three, and especially duty is dirty in lung spleen two.Exopathogenic factor is based on diseases caused by exogenous pathogenic factor six climate exopathogens, and the heresy of six climate exopathogens, Winter-Spring mostly is wind and cold, wind heat, or autumn is suddenly cold and suddenly hot, and exopathogen is taken advantage of a weak point in opponent's defence and invaded and bring out.Evil people's lung meridian, priming latent phlegm, stagnation of phlegm air flue, impairment of purifying and descending function of the lung, QI rising in reverse order expectorant is dynamic and be asthma.

Current infantile asthma has western medicine method and treatment by Chinese herbs method.Quick-acting cushion can make asthma attack symptom stop, and eliminates tracheospasm, contributes to breathing.The medicines such as albuterol (being also salbutamol) can be used by nebulizer or metered-dose inhaler.Some controlling medicines also show effect for prevention of asthma.Inhaled steroid is exactly one of them, and energy dephlogistication and swelling, avoid baby to pant.Above-mentioned Western medicine in a short time can effective Control of asthma, but life-time service easily produces drug resistance, even the state of an illness may be increased the weight of, how Control of asthma, China and even a challenge facing of the whole world are become, and Chinese medicine have action temperature and, onset is lasting and from the feature of basic treatment asthma, become the research and development viewpoint that current asthma medications is new.

Chinese patent application 201310440498.9 discloses a kind of pharmaceutical composition for the treatment of infantile asthma, and this pharmaceutical composition comprises following raw materials: Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Sophorae Flavescentis, Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Flos Matricariae chamomillae.This pharmaceutical composition plays certain clearing away heat-damp and promoting diuresis, the effect of preventing phlegm from forming and stopping coughing, but at diaphoresis cold expelling, depressed lung-energy dispersing aspect effect is not very remarkable.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition containing Folium Artemisiae Argyi for the treatment of infantile asthma, this Chinese medicine composition has diaphoresis cold expelling, depressed lung-energy dispersing, expelling phlegm for arresting cough, effect of soothing the liver dispelling the stagnated QI and clearing heat and moistening lung, also have that preparation technology is simple, good effect, side effect be low, taking convenience and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made under the prerequisite ensureing curative effect by this pharmaceutical composition to facilitate easy-to-use preparation.

Chinese medicine composition of the present invention is prepared from by the raw material of following parts by weight:

Flos Farfarae 18-30 part, Cortex Eucommiae 16-28 part, Semen Sinapis Albae 10-18 part, Folium Artemisiae Argyi 12-28 part, Ganoderma 14-22 part, Pericarpium Citri Reticulatae 4-10 part, Radix Asteris 8-16 part, Rhizoma Dioscoreae 2-10 part, Radix Aneurolepidii 2-6 part, Bulbus Fritillariae Cirrhosae 2-10 part, Rhopilema esculenta 2-10 part and Radix Glycyrrhizae 4-12 part.

Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

Flos Farfarae 18 parts, the Cortex Eucommiae 16 parts, Semen Sinapis Albae 10 parts, Folium Artemisiae Argyi 12 parts, Ganoderma 14 parts, Pericarpium Citri Reticulatae 4 parts, Radix Asteris 8 parts, Rhizoma Dioscoreae 2 parts, Radix Aneurolepidii 2 parts, Bulbus Fritillariae Cirrhosae 2 parts, Rhopilema esculenta 2 parts and 4 parts, Radix Glycyrrhizae.

Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

Flos Farfarae 30 parts, the Cortex Eucommiae 28 parts, Semen Sinapis Albae 18 parts, Folium Artemisiae Argyi 28 parts, Ganoderma 22 parts, Pericarpium Citri Reticulatae 10 parts, Radix Asteris 16 parts, Rhizoma Dioscoreae 10 parts, Radix Aneurolepidii 6 parts, Bulbus Fritillariae Cirrhosae 10 parts, Rhopilema esculenta 10 parts and 12 parts, Radix Glycyrrhizae.

Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

Flos Farfarae 20 parts, the Cortex Eucommiae 22 parts, Semen Sinapis Albae 14 parts, Folium Artemisiae Argyi 20 parts, Ganoderma 14 parts, Pericarpium Citri Reticulatae 8 parts, Radix Asteris 12 parts, Rhizoma Dioscoreae 6 parts, Radix Aneurolepidii 4 parts, Bulbus Fritillariae Cirrhosae 6 parts, Rhopilema esculenta 6 parts and 8 parts, Radix Glycyrrhizae.

Further, described Chinese medicine composition is made into capsule, granule, tablet or pill.

Accordingly, the preparation method of described Chinese medicine composition comprises following step:

S1: get the Cortex Eucommiae, wash away impurity, crushed after being dried, crosses 40-60 mesh sieve, adds the water of Cortex Eucommiae weight 10-15 times amount, soak 1-2 hour, reflux, extract, 2-3 time, each 1-3 hour, filters and retains residue, merging filtrate also heats to be concentrated at 60 DEG C surveys the extractum that relative density is 1.05-1.20, obtained Cortex Eucommiae extract;

S2: Flos Farfarae of withdrawing the money, Semen Sinapis Albae, Folium Artemisiae Argyi, Ganoderma, Pericarpium Citri Reticulatae, Radix Asteris, Rhizoma Dioscoreae, Radix Aneurolepidii, Bulbus Fritillariae Cirrhosae, Rhopilema esculenta and Radix Glycyrrhizae add described Cortex Eucommiae residue, pulverize, add the alcoholic solution of the 60-80% of medical material 4-8 times weight, reflux, extract, 2 times, each 8-16h, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60-70 DEG C of relative density be the concentrated solution of 1.15-1.25, obtains alcohol extraction concentrated solution;

S3: by described Cortex Eucommiae extract and the mixing of described alcohol extraction concentrated solution, vacuum belt type drying is carried out at 50-60 DEG C of temperature, drying pressure is-0.09MPa, charging rate is 12-18L/h, material strip transfer rate is 20-28cm/min, after drying, dry extract is pulverized, cross 100-200 mesh sieve, obtain Chinese medicine composition of the present invention.

Source, the nature and flavor of the present invention's component used, return through and effect:

Flos Farfarae: this product is the dry flower of feverfew coltsfoot; Acrid in the mouth, micro-hardship, warm in nature; Return lung meridian; Nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.

The Cortex Eucommiae: this product is the dry bark of the Eucommiaceae plant Cortex Eucommiae; Sweet in the mouth, warm in nature; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.

Semen Sinapis Albae: this product is the seed of crucifer Caulis et Folium Sinapis albee; Acrid in the mouth, warm in nature; Return lung, liver, spleen, stomach, pericardium channel; Reduce phlegm by drink, mass dissipating and swelling eliminating.

Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort; Taste acrid, bitter, warm, returns liver,spleen,kidney warp; Folium Artemisiae Argyi has the effects such as warming the meridian for stopping bleeding, dispersing cold for relieving pain, regulating menstruation are antiabortive, removing damp to relieve itching, dredge the meridian passage.

Ganoderma: this product is the dry sporophore of On Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. or Ganoderma; Sweet in the mouth, property is put down; GUIXIN, lung, liver, kidney channel; Strengthening by means of tonics, antiinflammatory, diuresis, kidney tonifying.

Pericarpium Citri Reticulatae: this product is the dry peel of rutaceae orange; Bitter in the mouth, pungent, warm in nature; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.

Radix Asteris: this product is the dry root and rhizome of feverfew Radix Asteris; Acrid in the mouth is bitter, warm in nature; Return lung meridian; Nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.

Rhizoma Dioscoreae: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae; Sweet in the mouth, property is put down; Return spleen, lung, kidney channel; Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.

Radix Aneurolepidii: this product is root or the herb that grass relies grass; Sweet in the mouth, micro-hardship, cold in nature; Return lung meridian; Clearing away heat-damp and promoting diuresis, relievings asthma, hemostasis.Bulbus Fritillariae Cirrhosae: this product is the dry bulb of liliaceous plant Bulbus Fritillariae Cirrhosae; Bitter in the mouth, sweet, cold nature; Return lung, heart channel; Clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.

Rhopilema esculenta: this product is Coelenterata Scyphozoa root space decomposition order Rhopilema esculenta section Rhopilema esculenta, is used as medicine with entirety; Salty in the mouth, property is put down; Return liver, kidney channel; Heat clearing away, reduces phlegm, removing food stagnancy, intestine moistening.

Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

The prescription analysis of Chinese medicine of the present invention:

According to the compatibility theory of the traditional Chinese medical science to the dialectical and Chinese crude drug for the treatment of infantile asthma disease, in conjunction with the body constitution of modern and the feature of modern pharmaceutical technology, the collocation ingredients of reasonable science, forms Chinese prescription of the present invention.Prescription of the present invention is with Flos Farfarae and Semen Sinapis Albae for monarch drug, clearing away lung-heat and moistening for dryness, relieving cough and resolving phlegm; With Folium Artemisiae Argyi, Radix Aneurolepidii, Bulbus Fritillariae Cirrhosae, Rhopilema esculenta and Radix Asteris for ministerial drug, relieving QI stagnancy in the stomach, nourishing YIN and moistening the lung, nourishing the lung to keep the adverse QI downward; With Ganoderma, Pericarpium Citri Reticulatae, the Cortex Eucommiae and Rhizoma Dioscoreae for adjuvant drug, strengthening by means of tonics, regulating qi-flowing for strengthening spleen, promote the production of body fluid lung benefiting; With Radix Glycyrrhizae for making medicine, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain; The all medicines of monarch coordinate, and collaborative promotion, complements each other, finally reach preventing phlegm from forming and stopping coughing, clearing heat and moistening lung, the effects such as regulating qi-flowing for strengthening spleen, thus have very significant therapeutic effect to infantile asthma disease.

Compared with prior art, the present invention has following technical advantage:

1, Chinese medicine composition of the present invention is compared with the medicine of other treatment infantile asthma, and at diaphoresis cold expelling, depressed lung-energy dispersing, expelling phlegm for arresting cough, the aspects such as soothing the liver dispelling the stagnated QI and clearing heat and moistening lung have more remarkable efficacy.

2, compared with the chemicals of Current therapeutic infantile asthma, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, efficiently solves the morbidity root of infantile asthma.

3, Chinese medicine composition of the present invention also has that compatibility science, preparation technology are simple, good effect, side effect are low, taking convenience and be easy to advantages such as applying.

Detailed description of the invention

It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.

embodiment 1

The embodiment of the present invention 1 Chinese medicine composition is prepared from by the raw material of following parts by weight:

Flos Farfarae 18 parts, the Cortex Eucommiae 16 parts, Semen Sinapis Albae 10 parts, Folium Artemisiae Argyi 12 parts, Ganoderma 14 parts, Pericarpium Citri Reticulatae 4 parts, Radix Asteris 8 parts, Rhizoma Dioscoreae 2 parts, Radix Aneurolepidii 2 parts, Bulbus Fritillariae Cirrhosae 2 parts, Rhopilema esculenta 2 parts and 4 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1: get the Cortex Eucommiae, washes away impurity, crushed after being dried, crosses 40 mesh sieves, add the water of Cortex Eucommiae weight 10 times amount, soak 1 hour, reflux, extract, 2 times, each 1 hour, filter and retain residue, merging filtrate also heats to be concentrated at 60 DEG C surveys the extractum that relative density is 1.05, obtained Cortex Eucommiae extract;

S2: Flos Farfarae of withdrawing the money, Semen Sinapis Albae, Folium Artemisiae Argyi, Ganoderma, Pericarpium Citri Reticulatae, Radix Asteris, Rhizoma Dioscoreae, Radix Aneurolepidii, Bulbus Fritillariae Cirrhosae, Rhopilema esculenta and Radix Glycyrrhizae add described Cortex Eucommiae residue, pulverize, add the alcoholic solution of 60% of medical material 4 times of weight, reflux, extract, 2 times, each 8h, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.15, obtains alcohol extraction concentrated solution;

S3: by described Cortex Eucommiae extract and the mixing of described alcohol extraction concentrated solution, carry out vacuum belt type drying at 50 DEG C of temperature, drying pressure is-0.09MPa, charging rate is 12L/h, and material strip transfer rate is 20cm/min, is pulverized by dry extract after drying, cross 100 mesh sieves, obtain Chinese medicine composition powder;

S4: get above-mentioned Chinese medicine composition fine powder 1 part, cane sugar powder 3 parts, 1.25 parts, dextrin and appropriate amount of ethanol, mixing, dry, pulverize into fine powder, incapsulates in shell, obtain the capsule of Chinese medicine composition.

embodiment 2

The embodiment of the present invention 2 Chinese medicine composition is prepared from by the raw material of following parts by weight:

Flos Farfarae 30 parts, the Cortex Eucommiae 28 parts, Semen Sinapis Albae 18 parts, Folium Artemisiae Argyi 28 parts, Ganoderma 22 parts, Pericarpium Citri Reticulatae 10 parts, Radix Asteris 16 parts, Rhizoma Dioscoreae 10 parts, Radix Aneurolepidii 6 parts, Bulbus Fritillariae Cirrhosae 10 parts, Rhopilema esculenta 10 parts and 12 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1: get the Cortex Eucommiae, washes away impurity, crushed after being dried, crosses 40 mesh sieves, add the water of Cortex Eucommiae weight 12 times amount, soak 2 hours, reflux, extract, 3 times, each 2 hours, filter and retain residue, merging filtrate also heats to be concentrated at 60 DEG C surveys the extractum that relative density is 1.05, obtained Cortex Eucommiae extract;

S2: Flos Farfarae of withdrawing the money, Semen Sinapis Albae, Folium Artemisiae Argyi, Ganoderma, Pericarpium Citri Reticulatae, Radix Asteris, Rhizoma Dioscoreae, Radix Aneurolepidii, Bulbus Fritillariae Cirrhosae, Rhopilema esculenta and Radix Glycyrrhizae add described Cortex Eucommiae residue, pulverize, add the alcoholic solution of 80% of medical material 8 times of weight, reflux, extract, 2 times, each 16h, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 70 DEG C of relative densities be the concentrated solution of 1.25, obtains alcohol extraction concentrated solution;

S3: by described Cortex Eucommiae extract and the mixing of described alcohol extraction concentrated solution, carry out vacuum belt type drying at 60 DEG C of temperature, drying pressure is-0.09MPa, charging rate is 18L/h, and material strip transfer rate is 28cm/min, is pulverized by dry extract after drying, cross 200 mesh sieves, obtain Chinese medicine composition powder;

S4: get above-mentioned Chinese medicine composition fine powder 1 part, cane sugar powder 3 parts, 1.25 parts, dextrin and appropriate amount of ethanol, soft material processed, adds lubricant after drying, tabletting, coating, obtains the tablet of Chinese medicine composition.

embodiment 3

The embodiment of the present invention 3 Chinese medicine composition is prepared from by the raw material of following parts by weight:

Flos Farfarae 20 parts, the Cortex Eucommiae 22 parts, Semen Sinapis Albae 14 parts, Folium Artemisiae Argyi 20 parts, Ganoderma 14 parts, Pericarpium Citri Reticulatae 8 parts, Radix Asteris 12 parts, Rhizoma Dioscoreae 6 parts, Radix Aneurolepidii 4 parts, Bulbus Fritillariae Cirrhosae 6 parts, Rhopilema esculenta 6 parts and 8 parts, Radix Glycyrrhizae.

Preparation method is with embodiment 1.

clinical observation on the therapeutic effect

1, case selection: in 240 routine infantile asthma clinical patients volunteers, boy patient 120 example, young girl patient 120 example, age bracket be 4-12 year, all patients all has typical symptoms of asthma, and in sex, age, the course of disease no difference of science of statistics.

2, diagnostic criteria:

(1) tcm diagnosis standard: formulate according to " TCM syndrome diagnostic criteria " content relevant in " Chinese medical disease Standardization of diagnosis and curative effect ", " new Chinese medicine clinical guidance principle " (2002) and " the senior book series Pediatrics of Chinese Medicine of Chinese medicine " (second edition) " asthma " that State Administration of Traditional Chinese Medicine issues:

Primary symptom: cough with asthma is out of breath, wheezing in larynx, expectoration thickness.

Secondary disease: heating, nausea and vomiting, poor appetite, abdominal distention, constipation or sticky, yellowish or reddish urine.

Tongue fur pulse condition: red tongue, thick and greasy fur, slippery and rapid pulse, or fingerprint is purple.

In above-mentioned standard, need possess main symptom 2, secondary card more than 2, tongue fur is indispensable, and diagnosable is damp and hot asthma.

(2) Western medicine diagnose standard: " children with asthma diagnosis and treatment guide " according to the revision in 2008 of department of pediatrics branch of Chinese Medical Association pneumatology group:

1. recurrent exerbation pant, cough, tachypnea, uncomfortable in chest, many with contact allergen, cold air, physics, chemical irritation, respiratory tract infection and motion etc. relevant, be everlasting night and (or) early morning show effect or aggravate;

2. during outbreak at two lung audible and be dispersed in or diffusivity, the wheezing sound based on expiratory phase, expiratory phase prolongation;

3. above-mentioned symptom and the sign effective or spontaneous remission through asthma treatment;

Panting 4. caused by other diseases, cough, tachypnea and breast vexed;

5. its atypical clinical manifestations person's (as without obviously panting or wheezing sound), at least should possess following 1: A, brinchial provocation test or motion activated test positive; B, alleged occurrence reversible airflow limitation; C, maximal expiratory flow (PEF) aberration rate every day (monitoring 1 ~ 2 week continuously) are higher than 20%.Meet 1. ~ 4. article or 4., 5. article person, can asthma be diagnosed as.

3, exclusion standard: 1. do not meet diagnostic criteria and inclusive criteria person; 2. the serious heart, liver, kidney, lung disease or congenital diseases are had; 3. severity is the children with bronchial asthma disease of severe and the person that occurs severe attack after including in; 4. to institute medicine allergy sufferers.

4, efficacy assessment standard: according to " new Chinese medicine guideline of clinical investigations ":

Clinic control: symptoms of asthma complete incidence graph, even if there is mild episode not need medication to alleviate once in a while;

Effective: obviously to alleviate before asthma attack comparatively, still need with glucocorticoid or bronchodilator;

Take a turn for the better: symptoms of asthma alleviates to some extent, still needs with glucocorticoid or bronchodilator;

Invalid: clinical symptoms is without improvement or increase the weight of on the contrary;

Total effective rate=(clinic control+effective+improvement)/total number of cases × 100%.

5, instructions of taking: 240 patient volunteers are divided into 3 groups at random, often organize 80 people, is respectively treatment A group, treatment B group and matched group, treatment A group, treatment B component do not take the capsule preparations and tablet that the embodiment of the present invention 1,2 prepares, every day 3 times, each 2, serve on 1 month.Matched group takes salbutamol sheet (Shanxi Yun Peng pharmaceutical Co. Ltd), each 2,3 times on the one, serve on 1 month.

6, therapeutic outcome: as shown in table 1.

table 1 therapeutic outcome

This test adopts salbutamol sheet as a control group, and by comparing with the therapeutic effect of Chinese medicine composition of the present invention, can find out that the efficacy result of traditional Chinese medicine composition for treating infantile asthma of the present invention is remarkable, its clinic control rate and total effective rate are far above matched group., wherein best with the therapeutic effect for the treatment of A group, total effective rate reaches 95%.Visible, the good effect of Chinese medicine composition of the present invention, clinic control rate is high, can be used as the drug use for the treatment of infantile asthma.

Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.

Claims (6)

1. treat the Chinese medicine composition containing Folium Artemisiae Argyi of infantile asthma, it is characterized in that, be prepared from by the raw material of following parts by weight:

Flos Farfarae 18-30 part, Cortex Eucommiae 16-28 part, Semen Sinapis Albae 10-18 part, Folium Artemisiae Argyi 12-28 part, Ganoderma 14-22 part, Pericarpium Citri Reticulatae 4-10 part, Radix Asteris 8-16 part, Rhizoma Dioscoreae 2-10 part, Radix Aneurolepidii 2-6 part, Bulbus Fritillariae Cirrhosae 2-10 part, Rhopilema esculenta 2-10 part and Radix Glycyrrhizae 4-12 part.

2. the Chinese medicine composition containing Folium Artemisiae Argyi for the treatment of infantile asthma as claimed in claim 1, is characterized in that, be prepared from by the raw material of following parts by weight:

Flos Farfarae 18 parts, the Cortex Eucommiae 16 parts, Semen Sinapis Albae 10 parts, Folium Artemisiae Argyi 12 parts, Ganoderma 14 parts, Pericarpium Citri Reticulatae 4 parts, Radix Asteris 8 parts, Rhizoma Dioscoreae 2 parts, Radix Aneurolepidii 2 parts, Bulbus Fritillariae Cirrhosae 2 parts, Rhopilema esculenta 2 parts and 4 parts, Radix Glycyrrhizae.

3. the Chinese medicine composition containing Folium Artemisiae Argyi for the treatment of infantile asthma as claimed in claim 1, is characterized in that, be prepared from by the raw material of following parts by weight:

Flos Farfarae 30 parts, the Cortex Eucommiae 28 parts, Semen Sinapis Albae 18 parts, Folium Artemisiae Argyi 28 parts, Ganoderma 22 parts, Pericarpium Citri Reticulatae 10 parts, Radix Asteris 16 parts, Rhizoma Dioscoreae 10 parts, Radix Aneurolepidii 6 parts, Bulbus Fritillariae Cirrhosae 10 parts, Rhopilema esculenta 10 parts and 12 parts, Radix Glycyrrhizae.

4. the Chinese medicine composition containing Folium Artemisiae Argyi for the treatment of infantile asthma as claimed in claim 1, is characterized in that, be prepared from by the raw material of following parts by weight:

Flos Farfarae 20 parts, the Cortex Eucommiae 22 parts, Semen Sinapis Albae 14 parts, Folium Artemisiae Argyi 20 parts, Ganoderma 14 parts, Pericarpium Citri Reticulatae 8 parts, Radix Asteris 12 parts, Rhizoma Dioscoreae 6 parts, Radix Aneurolepidii 4 parts, Bulbus Fritillariae Cirrhosae 6 parts, Rhopilema esculenta 6 parts and 8 parts, Radix Glycyrrhizae.

5. the Chinese medicine composition containing Folium Artemisiae Argyi of the treatment infantile asthma as described in any one of claim 1-4, it is characterized in that, described Chinese medicine composition is made into capsule, granule, tablet or pill.

6. the preparation method of the Chinese medicine composition containing Folium Artemisiae Argyi of the treatment infantile asthma as described in any one of claim 1-4, is characterized in that, comprise following step:

S1: get the Cortex Eucommiae, wash away impurity, crushed after being dried, crosses 40-60 mesh sieve, adds the water of Cortex Eucommiae weight 10-15 times amount, soak 1-2 hour, reflux, extract, 2-3 time, each 1-3 hour, filters and retains residue, merging filtrate also heats to be concentrated at 60 DEG C surveys the extractum that relative density is 1.05-1.20, obtained Cortex Eucommiae extract;

S2: Flos Farfarae of withdrawing the money, Semen Sinapis Albae, Folium Artemisiae Argyi, Ganoderma, Pericarpium Citri Reticulatae, Radix Asteris, Rhizoma Dioscoreae, Radix Aneurolepidii, Bulbus Fritillariae Cirrhosae, Rhopilema esculenta and Radix Glycyrrhizae add described Cortex Eucommiae residue, pulverize, add the alcoholic solution of the 60-80% of medical material 4-8 times weight, reflux, extract, 2 times, each 8-16h, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60-70 DEG C of relative density be the concentrated solution of 1.15-1.25, obtains alcohol extraction concentrated solution;

S3: by described Cortex Eucommiae extract and the mixing of described alcohol extraction concentrated solution, vacuum belt type drying is carried out at 50-60 DEG C of temperature, drying pressure is-0.09MPa, charging rate is 12-18L/h, material strip transfer rate is 20-28cm/min, after drying, dry extract is pulverized, cross 100-200 mesh sieve, obtain Chinese medicine composition of the present invention.