CN105308180A - 胡萝卜素羟化酶及其用于产生类胡萝卜素的用途 - Google Patents

胡萝卜素羟化酶及其用于产生类胡萝卜素的用途 Download PDF

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Publication number
CN105308180A
CN105308180A CN201380066965.4A CN201380066965A CN105308180A CN 105308180 A CN105308180 A CN 105308180A CN 201380066965 A CN201380066965 A CN 201380066965A CN 105308180 A CN105308180 A CN 105308180A
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China
Prior art keywords
polypeptide
sequence
nucleic acid
microorganism
carotenoid
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Pending
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CN201380066965.4A
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English (en)
Chinese (zh)
Inventor
C·法雷尔
M·马约尔加
B·谢弗勒
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DSM IP Assets BV
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DSM IP Assets BV
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Priority to CN202110711179.1A priority Critical patent/CN113774034A/zh
Publication of CN105308180A publication Critical patent/CN105308180A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13129—Beta-carotene 3-hydroxylase (1.14.13.129)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
CN201380066965.4A 2012-12-20 2013-08-27 胡萝卜素羟化酶及其用于产生类胡萝卜素的用途 Pending CN105308180A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110711179.1A CN113774034A (zh) 2012-12-20 2013-08-27 胡萝卜素羟化酶及其用于产生类胡萝卜素的用途

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12198352 2012-12-20
EP12198352.2 2012-12-20
US201361830273P 2013-06-03 2013-06-03
US61/830,273 2013-06-03
PCT/IB2013/056583 WO2014096990A1 (en) 2012-12-20 2013-08-27 Carotene hydroxylase and its use for producing carotenoids

Related Child Applications (1)

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CN202110711179.1A Division CN113774034A (zh) 2012-12-20 2013-08-27 胡萝卜素羟化酶及其用于产生类胡萝卜素的用途

Publications (1)

Publication Number Publication Date
CN105308180A true CN105308180A (zh) 2016-02-03

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CN201380066965.4A Pending CN105308180A (zh) 2012-12-20 2013-08-27 胡萝卜素羟化酶及其用于产生类胡萝卜素的用途
CN202110711179.1A Withdrawn CN113774034A (zh) 2012-12-20 2013-08-27 胡萝卜素羟化酶及其用于产生类胡萝卜素的用途

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Country Status (9)

Country Link
US (1) US10081797B2 (https=)
EP (1) EP2935570B1 (https=)
JP (1) JP6319697B2 (https=)
KR (1) KR102113368B1 (https=)
CN (2) CN105308180A (https=)
BR (1) BR112015014556A2 (https=)
CA (1) CA2895298A1 (https=)
EA (1) EA201500663A1 (https=)
WO (1) WO2014096990A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111454854A (zh) * 2020-05-02 2020-07-28 昆明理工大学 一株产虾青素的红冬孢酵母基因工程菌株
CN113413377A (zh) * 2021-06-23 2021-09-21 陕西中医药大学 3-羟基-β-紫罗兰酮在制备血管相关性疾病的药物中的用途
CN118126851A (zh) * 2024-03-27 2024-06-04 黄石曼菲特生物科技有限公司 一株高产虾青素、角黄素及β-胡萝卜素的解脂亚罗酵母及其培养方法与应用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX355028B (es) * 2012-01-23 2018-03-28 Dsm Ip Assets Bv Produccion de diterpeno.
CN108779451A (zh) * 2016-01-08 2018-11-09 帝斯曼知识产权资产管理有限公司 解脂耶氏酵母的交配型转换
CN109536518A (zh) * 2018-10-31 2019-03-29 昆明理工大学 一种八氢番茄红素脱氢酶基因RKcrtI及其应用
CN114317307B (zh) * 2021-12-30 2024-05-10 广州智特奇生物科技股份有限公司 一种可提高虾青素生物合成产量的基因工程菌及其构建方法与应用
US20250109422A1 (en) 2022-02-02 2025-04-03 Dsm Ip Assets B.V. Yarrowia production process
KR102828745B1 (ko) * 2022-03-23 2025-07-03 씨제이제일제당 주식회사 헤마토코쿠스 플루비알리스 유래의 제라닐제라닐 피로포스페이트 신타아제를 포함하는 카로티노이드 또는 이를 전구체로 하는 물질 생산 미생물 및 이를 이용한 카로티노이드 또는 레티노이드 생산방법
CN115074410B (zh) * 2022-06-30 2025-08-19 武汉合生科技有限公司 一种生物合成虾青素的方法及载体
CN115895922B (zh) * 2022-12-19 2024-04-02 云南大学 一株高产类胡萝卜素的禾本红酵母及其应用
WO2025042250A1 (ko) * 2023-08-23 2025-02-27 서울시립대학교 산학협력단 지아잔틴을 생산하는 해양 미생물 셀룰로파가 옴니버스코리아 msk1 (cellulophaga omnivescoria msk1) 균주 및 이를 이용한 바이오매스로부터 지아잔틴 생산방법
CN118580979B (zh) * 2024-06-27 2025-04-29 杭州精构生物科技有限责任公司 一种高产虾青素的工程菌及其构建方法与应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1352689A (zh) * 1999-04-09 2002-06-05 Basf公司 胡萝卜素羟化酶和制备叶黄素衍生物的方法
WO2005019467A1 (de) * 2003-08-18 2005-03-03 Sungene Gmbh Verfahren zur herstellung von ketocarotinoiden in genetisch veränderten, nichthumanen organismen
CN1759173A (zh) * 2003-01-09 2006-04-12 巴斯福股份公司 使用经遗传修饰的布拉霉属生物产生类胡萝卜素或其前体的方法、由所述方法产生的类胡萝卜素或其前体及它们的用途
CN102021197A (zh) * 2009-09-11 2011-04-20 中国科学院海洋研究所 一种植物双价表达载体及其构建方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69018117T2 (de) 1989-04-21 1995-10-26 Kirin Brewery Zur Synthese von Karotinoiden verwendbare DNA-Sequenzen.
CA2055447C (en) 1990-03-02 2006-12-19 Rodney Lee Ausich Biosynthesis of carotenoids in genetically engineered hosts
WO1995018220A1 (en) 1993-12-27 1995-07-06 Kirin Beer Kabushiki Kaisha Dna chain useful for xanthophyll synthesis and process for producing xanthophylls
DE69631924T2 (de) 1995-06-09 2004-08-12 Dsm Ip Assets B.V. Fermentative Herstellung von Carotenoiden
US5744341A (en) 1996-03-29 1998-04-28 University Of Maryland College Park Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes
DE19801120A1 (de) 1998-01-15 1999-07-22 Basf Ag Orotidin-5'-Phosphatdecarboxylase-Gen, Genkonstrukt enthaltend dieses Gen und seine Verwendung
US20060099670A1 (en) * 2003-01-09 2006-05-11 Markus Matuschek Method for the genetic modification of organisms of the genus blakeslea, corresponding organisms and the use of the same
US20060234333A1 (en) * 2003-01-09 2006-10-19 Basf Aktiengesellschaft Patents, Trademarks And Licenses Method for producing carotenoids or their precursors using genetically modified organisms of the blakeslea genus, carotenoids or their precursors produced by said method and use thereof
DE102004007624A1 (de) * 2004-02-17 2005-09-15 Sungene Gmbh & Co. Kgaa Neue Ketolasen und Verfahren zur Herstellung von Ketocarotinoiden
JP2006075097A (ja) * 2004-09-10 2006-03-23 Tadashi Matsunaga カロテノイド生産能を有する形質転換体及びカロテノイドの生産方法
EP1866428A2 (en) 2005-03-18 2007-12-19 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
JP2007254459A (ja) * 2006-02-21 2007-10-04 Yamaha Motor Co Ltd アスタキサンチンの保存安定性が高い緑藻抽出物
KR20090046376A (ko) * 2007-11-06 2009-05-11 부경대학교 산학협력단 카로티노이드 생합성 유전자로 형질 전환된 효모 및 이를이용한 아스타잔틴의 대량 생산 방법
WO2010079032A1 (en) 2008-12-17 2010-07-15 Basf Plant Science Gmbh Production of ketocarotenoids in plants

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1352689A (zh) * 1999-04-09 2002-06-05 Basf公司 胡萝卜素羟化酶和制备叶黄素衍生物的方法
CN1759173A (zh) * 2003-01-09 2006-04-12 巴斯福股份公司 使用经遗传修饰的布拉霉属生物产生类胡萝卜素或其前体的方法、由所述方法产生的类胡萝卜素或其前体及它们的用途
WO2005019467A1 (de) * 2003-08-18 2005-03-03 Sungene Gmbh Verfahren zur herstellung von ketocarotinoiden in genetisch veränderten, nichthumanen organismen
CN102021197A (zh) * 2009-09-11 2011-04-20 中国科学院海洋研究所 一种植物双价表达载体及其构建方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111454854A (zh) * 2020-05-02 2020-07-28 昆明理工大学 一株产虾青素的红冬孢酵母基因工程菌株
CN111454854B (zh) * 2020-05-02 2022-05-06 昆明理工大学 一株产虾青素的红冬孢酵母基因工程菌株
CN113413377A (zh) * 2021-06-23 2021-09-21 陕西中医药大学 3-羟基-β-紫罗兰酮在制备血管相关性疾病的药物中的用途
CN118126851A (zh) * 2024-03-27 2024-06-04 黄石曼菲特生物科技有限公司 一株高产虾青素、角黄素及β-胡萝卜素的解脂亚罗酵母及其培养方法与应用

Also Published As

Publication number Publication date
KR20150099787A (ko) 2015-09-01
JP6319697B2 (ja) 2018-05-09
KR102113368B1 (ko) 2020-05-22
CN113774034A (zh) 2021-12-10
JP2016505259A (ja) 2016-02-25
BR112015014556A2 (pt) 2017-10-10
EP2935570B1 (en) 2018-09-19
EA201500663A1 (ru) 2015-12-30
US20150315550A1 (en) 2015-11-05
WO2014096990A8 (en) 2015-12-23
CA2895298A1 (en) 2014-06-26
WO2014096990A1 (en) 2014-06-26
US10081797B2 (en) 2018-09-25
EP2935570A1 (en) 2015-10-28

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