CN105288721A - Liquid band-aid and preparation technology thereof - Google Patents
Liquid band-aid and preparation technology thereof Download PDFInfo
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- CN105288721A CN105288721A CN201510669508.5A CN201510669508A CN105288721A CN 105288721 A CN105288721 A CN 105288721A CN 201510669508 A CN201510669508 A CN 201510669508A CN 105288721 A CN105288721 A CN 105288721A
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Abstract
The invention relates to liquid band-aid and a preparation technology thereof. The liquid band-aid is prepared from the following components in percentage by weight: 5%-20% of a film-forming agent, 4%-12% of a softening agent, 0.1-8% of an antibacterial agent, 3%-10% of a haemostatic and analgetic agent, 1%-5% of a healing agent, and 53%-83% of a solvent. The preparation technology comprises the following steps: adding 5%-20% of the film-forming agent and 53-83% of the solvent into a reactor, and soaking for 1-2 h; heating to 65 DEG C to 70 DEG C so that the film-forming agent completely swells; and sequentially adding the softening agent, the antibacterial agent, the haemostatic and analgetic agent and the healing agent into the reactor under stirring, and uniformly stirring to prepare the liquid band-aid. The liquid band-aid overcomes the defects that the traditional band-aid is not attractive, and the wound can not move freely. The liquid band-aid has the characteristics of being rapid in hemostatic effect, strong in inflammation diminishing and bacteria killing properties, and low in cost, and the wound part can move freely.
Description
Technical field
The present invention relates to a kind of adhesive bandage.Particularly relating to one can conveniently spread upon on wound, and wound is isolated from the outside rapidly the liquid adhesive bandage of anti-inflammation and sterilization and preparation technology thereof.
Background technology
In daily life, people are normal because hurting health because of carelessness, leave wound.If processed not in time for this kind of wound, usually can infect, bring graver results, especially in summer, easy inflammation.
For this kind of wound, be all adopt adhesive bandage to be attached to the object little wound surface reaching anti-inflammation and sterilization usually.Adhesive bandage common on existing market, a kind ofly adds non-woven fabrics for medical proof fabric, and another kind adds non-woven fabrics for PU film, is attached on little wound surface.The adhesive bandage of this frame mode is attached on wound surface, and one affects the freely movable of wound site, also affects attractive in appearance in addition.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of and does not affect the appearance, the liquid adhesive bandage of wound freedom of movement and preparation technology thereof.
The technical solution adopted in the present invention is: a kind of liquid adhesive bandage, by weight percentage, has: film former 5%-20%, softening agent 4%-12%, antibacterial 0.1%-8%, hemostasis and pain-relieving agent 3%-10%, consolidant 1%-5%, solvent 53%-83%.
Described film former is the one in casein, polyvinyl alcohol, hydroxy methocel, polyvinylpyrrolidone, pectin, gelatin and xanthan gum.
Described softening agent is the one in glycerol, propylene glycol, sorbitol.
Described antibacterial is the one in povidone iodine, chlorhexidine acetate, chlorhexidine gluconate, ethacridine lactate.
Described hemostasis and pain-relieving agent is notoginseng extract.
Described consolidant is Sodium Azulenesulfonate or zinc sulfadiazine.
Described solvent is concentration is 35%-45% ethanol water.
A preparation technology for liquid adhesive bandage, comprises the steps:
1) add film former 5%-20% and solvent 53%-83% in the reactor, soak 1 ~ 2 hour;
2) be heated to 65 DEG C ~ 70 DEG C degree, make film former fully swelling;
3) softening agent, antibacterial, hemostasis and pain-relieving agent and consolidant is added successively under stirring, stir.
A kind of liquid adhesive bandage of the present invention and preparation technology thereof, film former wherein, softening agent, solvent can be made into the liquid conveniently smeared, and wound is isolated from the outside rapidly, also do not affect the normal activity smearing position; Antibacterial wherein can prevent wound infection; Hemorrhage prevents wound Continuous hemorrhage; Consolidant can promote wound healing.Therefore, the impact that the invention solves traditional bandage is attractive in appearance, the movable comfortless defect of wound.Feature of the present invention is that haemostatic effect is fast, and anti-inflammation and sterilization ability is strong, and wound site freedom of movement, cost is low.
Detailed description of the invention
Below in conjunction with embodiment, a kind of liquid adhesive bandage of the present invention and preparation technology thereof are described in detail.
A kind of liquid adhesive bandage of the present invention, by weight percentage, includes: film former 5%-20%, softening agent 4%-12%, antibacterial 0.1%-8%, hemostasis and pain-relieving agent 3%-10%, consolidant 1%-5%, solvent 53%-83%.Wherein,
Described film former is the one in casein, polyvinyl alcohol, hydroxy methocel, polyvinylpyrrolidone, pectin, gelatin and xanthan gum;
Described softening agent is the one in glycerol, propylene glycol, sorbitol;
Described antibacterial is the one in povidone iodine, chlorhexidine acetate, chlorhexidine gluconate, ethacridine lactate;
Described hemostasis and pain-relieving agent is notoginseng extract;
Described consolidant is Sodium Azulenesulfonate or zinc sulfadiazine;
Described solvent is concentration is 35%-45% ethanol water.
The preparation technology of a kind of liquid adhesive bandage of the present invention, comprises the steps:
1) add film former 5%-20% and solvent 53%-83% in the reactor, soak 1 ~ 2 hour;
2) be heated to 65 DEG C ~ 70 DEG C, make film former fully swelling;
3) softening agent, antibacterial, hemostasis and pain-relieving agent and consolidant is added successively under stirring, stir.
Provide instantiation below:
Embodiment 1: to prepare 100g, get by weight:
1) add casein 5g and 35% ethanol 83g in the reactor, soak 1 hour;
2) be heated to 65 DEG C ~ 70 DEG C, make casein fully swelling;
3) glycerol 7.5g, povidone iodine powder 0.5g, notoginseng extract 3g is added successively, Sodium Azulenesulfonate 1g under stirring, stir.
Embodiment 2: to prepare 100g, get by weight:
1) add polyvinyl alcohol 15g and 40% ethanol 66.5g in the reactor, soak 1.5 hours;
2) be heated to 65 DEG C ~ 70 DEG C, make polyvinyl alcohol fully swelling;
3) glycerol 6g, povidone iodine powder 2.5g, notoginseng extract 5g is added successively, Sodium Azulenesulfonate 5g under stirring, stir.
Embodiment 3: to prepare 100g, get by weight:
1) add hydroxy methocel 20g and 45% ethanol 53g in the reactor, soak 2 hours;
2) be heated to 65 DEG C ~ 70 DEG C, make hydroxy methocel fully swelling;
3) propylene glycol 12g, povidone iodine powder 5g, notoginseng extract 7g is added successively, Sodium Azulenesulfonate 3g under stirring, stir.
Embodiment 4: to prepare 100g, get by weight:
1) add polyvinylpyrrolidone 6g and 45% ethanol 69g in the reactor, soak 2 hours;
2) be heated to 65 DEG C ~ 70 DEG C, make polyvinylpyrrolidone fully swelling;
3) glycerol 10g, ethacridine lactate 2g, notoginseng extract 10g is added successively, Sodium Azulenesulfonate 3g under stirring, stir.
Embodiment 5: to prepare 100g, get by weight:
1) add casein 6g and 35% ethanol 80.5g in the reactor, soak 1.5 hours;
2) be heated to 65 DEG C ~ 70 DEG C, make casein fully swelling;
3) glycerol 7g, chlorhexidine acetate 0.5g, notoginseng extract 4g is added successively, Sodium Azulenesulfonate 2g under stirring, stir.
Embodiment 6: to prepare 100g, get by weight:
1) add polyvinyl alcohol 12g and 40% ethanol 63g in the reactor, soak 1 hour;
2) be heated to 65 DEG C ~ 70 DEG C, make polyvinyl alcohol fully swelling;
3) glycerol 12g, chlorhexidine gluconate 3g, notoginseng extract 5g is added successively, Sodium Azulenesulfonate 5g under stirring, stir.
Embodiment 7: to prepare 100g, get by weight:
1) add hydroxy methocel 6g and 45% ethanol 70g in the reactor, soak 1.5 hours;
2) be heated to 65 DEG C ~ 70 DEG C, make hydroxy methocel fully swelling;
3) propylene glycol 10g, ethacridine lactate 5g, notoginseng extract 7g is added successively, Sodium Azulenesulfonate 2g under stirring, stir.
Embodiment 8: to prepare 100g, get by weight:
1) add pectin 5g and 45% ethanol 71g in the reactor, soak 2 hours;
2) be heated to 65 DEG C ~ 70 DEG C, make polyvinylpyrrolidone fully swelling;
3) glycerol 7g, chlorhexidine gluconate 8g, notoginseng extract 6g is added successively, Sodium Azulenesulfonate 3g under stirring, stir.
Embodiment 9: to prepare 100g, get by weight:
1) add xanthan gum 9g and 40% ethanol 65g in the reactor, soak 1 hour;
2) be heated to 65 DEG C ~ 70 DEG C, hydroxy methocel divided swelling;
3) glycerol 11g, ethacridine lactate 5g, notoginseng extract 7g is added successively, zinc sulfadiazine 3g under stirring, stir.
Embodiment 10: to prepare 100g, get by weight:
1) add polyvinylpyrrolidone 6g and 45% ethanol 73g in the reactor, soak 1 hour;
2) be heated to 65 DEG C ~ 70 DEG C, make polyvinylpyrrolidone fully swelling;
3) propylene glycol 7g, povidone iodine powder 4g, notoginseng extract 5g is added successively, zinc sulfadiazine 5g under stirring, stir.
Embodiment 11: to prepare 100g, get by weight:
1) add casein 6g and 35% ethanol 78.9g in the reactor, soak 1.5 hours;
2) be heated to 65 DEG C ~ 70 DEG C, make casein fully swelling;
3) glycerol 7g, chlorhexidine acetate 0.1g, notoginseng extract 4g is added successively, zinc sulfadiazine 4g under stirring, stir.
Embodiment 12: to prepare 100g, get by weight:
1) add gelatin 15g and 35% ethanol 71g in the reactor, soak 1.5 hours;
2) be heated to 65 DEG C ~ 70 DEG C, make hydroxy methocel fully swelling;
3) sorbitol 4g, chlorhexidine gluconate 2.5g, notoginseng extract 4g is added successively, Sodium Azulenesulfonate 3.5g under stirring, stir.
Present invention specifies compound basis and the prescription feature of liquid adhesive bandage; also more multiple embodiments are illustrated; but not by the restriction of these embodiments; under the prerequisite not departing from essence of the present invention and scope; the present invention also can changes and improvements to some extent; these improve also in claimed scope, define with claims equivalence.
Above 12 embodiments, each embodiment, by 30 parts, formulated sample, prepares 360 parts, sample altogether, finds the volunteer being ready to try out, when unexpected skin tears, this product is applied to injury, prevents hindering product and be subject to bacteriological infection, hemostasis and pain-relieving, promotes wound healing.Result on trial shows, the product of these 12 embodiments, wound and the external world all can be made to isolate rapidly, prevent bacteriological infection, and soon, no one's wound infection on probation, obvious effective rate is 100% for pain relief, healing.Visible this patent product really has and prevents hindering product and be subject to bacteriological infection, hemostasis and pain-relieving, promotes the effect of wound healing, is worthy to be popularized.
Claims (8)
1. a liquid adhesive bandage, is characterized in that, by weight percentage, has: film former 5%-20%, softening agent 4%-12%, antibacterial 0.1%-8%, hemostasis and pain-relieving agent 3%-10%, consolidant 1%-5%, solvent 53%-83%.
2. a kind of liquid adhesive bandage according to claim 1, is characterized in that, described film former is the one in casein, polyvinyl alcohol, hydroxy methocel, polyvinylpyrrolidone, pectin, gelatin and xanthan gum.
3. a kind of liquid adhesive bandage according to claim 1, is characterized in that, described softening agent is the one in glycerol, propylene glycol, sorbitol.
4. a kind of liquid adhesive bandage according to claim 1, is characterized in that, described antibacterial is the one in povidone iodine, chlorhexidine acetate, chlorhexidine gluconate, ethacridine lactate.
5. a kind of liquid adhesive bandage according to claim 1, is characterized in that, described hemostasis and pain-relieving agent is notoginseng extract.
6. a kind of liquid adhesive bandage according to claim 1, is characterized in that, described consolidant is Sodium Azulenesulfonate or zinc sulfadiazine.
7. a kind of liquid adhesive bandage according to claim 1, is characterized in that, described solvent is concentration is 35%-45% ethanol water.
8. a preparation technology for liquid adhesive bandage described in claim 1, is characterized in that, comprise the steps:
1) add film former 5%-20% and solvent 53%-83% in the reactor, soak 1 ~ 2 hour;
2) be heated to 65 DEG C ~ 70 DEG C degree, make film former fully swelling;
3) softening agent, antibacterial, hemostasis and pain-relieving agent and consolidant is added successively under stirring, stir.
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105816547A (en) * | 2016-03-30 | 2016-08-03 | 吴美燕 | Method for preparing band-aid unguent |
| CN105999393A (en) * | 2016-07-15 | 2016-10-12 | 蓝佳堂生物医药（福建）有限公司 | Liquid band-aid and preparation method thereof |
| CN106075560A (en) * | 2016-07-26 | 2016-11-09 | 上海第二工业大学 | A kind of preparation method of polymeric liquid adhesive bandage |
| CN106540316A (en) * | 2016-12-08 | 2017-03-29 | 苏州艾博迈尔新材料有限公司 | A kind of antibacterial liquid medical dressing and preparation method thereof |
| CN106727446A (en) * | 2016-12-26 | 2017-05-31 | 广州立白企业集团有限公司 | Film-forming composition, diaphragm and application |
| CN106924803A (en) * | 2017-05-05 | 2017-07-07 | 江南大学 | A kind of high-performance medical use liquid adhesive bandage and preparation method thereof |
| CN107308144A (en) * | 2017-06-29 | 2017-11-03 | 杨阳 | A kind of liquid preparation and its preparation method and application |
| CN108904530A (en) * | 2018-08-03 | 2018-11-30 | 安徽省银锂子生物科技发展有限公司 | A kind of bactericidal nano-silver hemostatic composition |
| CN109464696A (en) * | 2018-12-05 | 2019-03-15 | 福建易元生物医药有限公司 | A kind of atomizing liquid adhesive bandage |
| CN109731132A (en) * | 2019-01-30 | 2019-05-10 | 中国人民解放军西部战区总医院 | The liquid bandage of alleviation arthralgia containing Ginger P.E |
| CN110201218A (en) * | 2018-12-23 | 2019-09-06 | 山东泰开制药有限公司 | Liquid adhesive bandage and preparation method thereof |
| CN111184906A (en) * | 2020-02-19 | 2020-05-22 | 江南大学 | PVA-based liquid dressing and preparation method thereof |
| CN112245652A (en) * | 2020-10-16 | 2021-01-22 | 合肥贝壳派创新科技有限公司 | Bacteriostatic liquid band-aid capable of quickly forming film and preparation method thereof |
| CN113425503A (en) * | 2021-06-24 | 2021-09-24 | 上海海洋大学 | Compound anti-inflammatory composition band-aid and preparation method thereof |
| WO2022234889A1 (en) * | 2021-05-03 | 2022-11-10 | 수바이오 주식회사 | Adhesive transparent multifunctional wound covering material and method for manufacturing same |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816547A (en) * | 2016-03-30 | 2016-08-03 | 吴美燕 | Method for preparing band-aid unguent |
| CN105999393A (en) * | 2016-07-15 | 2016-10-12 | 蓝佳堂生物医药（福建）有限公司 | Liquid band-aid and preparation method thereof |
| CN106075560A (en) * | 2016-07-26 | 2016-11-09 | 上海第二工业大学 | A kind of preparation method of polymeric liquid adhesive bandage |
| CN106540316A (en) * | 2016-12-08 | 2017-03-29 | 苏州艾博迈尔新材料有限公司 | A kind of antibacterial liquid medical dressing and preparation method thereof |
| CN106727446B (en) * | 2016-12-26 | 2019-09-17 | 广州立白企业集团有限公司 | Film-forming composition, protective film and application |
| CN106727446A (en) * | 2016-12-26 | 2017-05-31 | 广州立白企业集团有限公司 | Film-forming composition, diaphragm and application |
| CN106924803A (en) * | 2017-05-05 | 2017-07-07 | 江南大学 | A kind of high-performance medical use liquid adhesive bandage and preparation method thereof |
| CN107308144A (en) * | 2017-06-29 | 2017-11-03 | 杨阳 | A kind of liquid preparation and its preparation method and application |
| CN108904530A (en) * | 2018-08-03 | 2018-11-30 | 安徽省银锂子生物科技发展有限公司 | A kind of bactericidal nano-silver hemostatic composition |
| CN109464696A (en) * | 2018-12-05 | 2019-03-15 | 福建易元生物医药有限公司 | A kind of atomizing liquid adhesive bandage |
| CN110201218A (en) * | 2018-12-23 | 2019-09-06 | 山东泰开制药有限公司 | Liquid adhesive bandage and preparation method thereof |
| CN109731132A (en) * | 2019-01-30 | 2019-05-10 | 中国人民解放军西部战区总医院 | The liquid bandage of alleviation arthralgia containing Ginger P.E |
| CN109731132B (en) * | 2019-01-30 | 2021-05-11 | 中国人民解放军西部战区总医院 | Liquid bandage containing rhizoma Zingiberis recens extract for relieving arthralgia |
| CN111184906A (en) * | 2020-02-19 | 2020-05-22 | 江南大学 | PVA-based liquid dressing and preparation method thereof |
| CN111184906B (en) * | 2020-02-19 | 2020-12-29 | 江南大学 | PVA-based liquid dressing and preparation method thereof |
| CN112245652A (en) * | 2020-10-16 | 2021-01-22 | 合肥贝壳派创新科技有限公司 | Bacteriostatic liquid band-aid capable of quickly forming film and preparation method thereof |
| WO2022234889A1 (en) * | 2021-05-03 | 2022-11-10 | 수바이오 주식회사 | Adhesive transparent multifunctional wound covering material and method for manufacturing same |
| CN113425503A (en) * | 2021-06-24 | 2021-09-24 | 上海海洋大学 | Compound anti-inflammatory composition band-aid and preparation method thereof |
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Address after: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Applicant after: Tianjin top pharmaceutical Limited by Share Ltd Address before: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Applicant before: Tianjin top pharmaceutical technology Co., Ltd. |
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| COR | Change of bibliographic data | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A liquid band aid and its preparation technology Effective date of registration: 20210318 Granted publication date: 20180828 Pledgee: Business Department of Bank of Tianjin Co.,Ltd. Pledgor: Tianjin top pharmaceutical Limited by Share Ltd. Registration number: Y2021120000008 |