CN105288495A - Medicine composition for treating primary dysmenorrhea accompanied by acne and preparation method thereof - Google Patents
Medicine composition for treating primary dysmenorrhea accompanied by acne and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a medicine composition for treating primary dysmenorrhea accompanied by acne and a preparation method thereof. The traditional Chinese medicine preparation is prepared from medicinal raw materials: rhizoma cyperi, radix curcumae, Ligusticum wallichii, bighead atractylodes rhizome, pericarpium citri reticulatae, rhizoma smilacis glabrae, Chinese holly leaf, Ludwigia repens, lalang grass rhizome, radix puerariae and glycyrrhiza uralensis. The medicine composition prepared from the combination of the raw materials has the effects of soothing liver-qi stagnation, removing blood stasis , clearing away heat and toxic materials, nourishing yin and purging intense heat, and nourishing blood, communicates inside and outside, achieves double purposes of improving the acne in a process of treating liver depression blood-heat type dysmenorrhea, has a definite clinical effect, less side effect and better patient compliance, and is convenient to take, capable of effectively alleviating the burden and the pain of a patent, capable of achieving the purpose of treating both symptoms and root causes and worthy of being clinically generalized and applied.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of primary dysmenorrhea for the treatment of and accompany pharmaceutical composition of acne and preparation method thereof.
Background technology
Dysmenorrhea is one of modal disease of gynecological, and its incidence rate report differs, and account for 42% ~ 90%, wherein severe pain is through accounting for 18%, nausea and vomiting can be accompanied, dripping cold sweat, deadly cold hand and foot time serious, very then faint, affect life and work more, unfavorable to the physical and mental health of women.
About dysmenorrhea, motherland's medical science has the record such as " menalgia ", " hanging pain over the perineum ", " through the lower cattle diaphragm of row ".All there is periodically lower abdomen pain women on the occasion of menstrual period or front and back of passing through in ancient Chinese medicine doctor, or pain draws waist sacrum, and very then severe pain is fainted, and is called dysmenorrhea.About the etiology and pathogenesis of dysmenorrhea, it is relevant with physiological environment special before and after ferritic and menstrual period, menstrual period that modern Chinese medicine thinks that it occurs.Between non-menstrual period, punching appoints QI and blood gentle, and paathogenic factor can not cause that punching is appointed, the uterus stasis of blood is stagnant or not enough, therefore pain does not occur, and before and after menstrual period or menstrual period, the sea of blood rushes down excessive by being completely full of, uterus QI and blood by arrogant blood prosperous to through after temporarily empty, QI and blood change is anxious to gather, paathogenic factor is taken the opportunity and does, make QI-blood circulation not smooth, the circulation of uterus menses is obstructed, so that stagnation of QI and blood may bring about pain; Or cause punching appoint a uterus lose in moisten support not flourish and pain.Take a broad view of many doctor's documents, all unanimously think that the basic pathogenesis of dysmenorrhea is " stagnation of QI and blood may bring about pain ", " not Rong Ze pain ".
Homeliness type acne is the commonly encountered diseases of department of dermatologry, be many with women in outpatient, clinical manifestation is inflamed papules, secondary pustule, tuberosity, cyst etc., most of clinicist notices that 1 levels in female patients with acne and its menstruation have very large contacting in addition, the acne of quite a few female patients often increases the weight of premenstruum or menstrual period, and postmenstruation alleviates gradually, and some patients is also with dysmenorrhea.
" Cuo " head sees " Plain Questions vital QI of the body connecting with natural QI gas opinion ", its cloud: " sweating is shown in wet, and be Sheng Cuo Rush ... exposure to the wind after sweating due to overstrain, invasion of pathogenic cold is Zha, and strongly fragrant is Cuo." tentatively disclosing the etiology and pathogenesis of acne, i.e. organism fatigue, defends gas phase to after virtual loss or sweating, and pore is hollow, and ailment said due to cold or exposure, cold-evil or damp invade, knot of mutually fighting, stasis local and to send out be acne." the large opinion of Plain Questions YIN YANG classification of natural phenomena " is said: " excess of YIN is YANG disease then, and the excess of YANG is YIN diseasei then." internal organs imbalance of YIN and YANG, negative and positive of qi and blood is not normal, and punching is appointed and superintended and directed band damage, and kidney-menses-punching times-uterus Reproductive Axis functional imbalance etc. all can lead acnegenic morbidity.
At present, treatment menoxenia medicine have the large class of Western medicine and Chinese medicine two, but this two classes medicine all can not prevent or Acne treatment, and western medicine menoxenia or dysmenorrhea administration time long, curative effect is not thorough, not only easily cause gastrointestinal reaction, easily increase the weight of endocrine disturbance again, cause amenorrhea or menoxenia, even infertile, and although existing Chinese patent medicine preparation can treat female irregular menstruation, offer limited effectiveness, and the acne occurred together to menoxenia is often invalid.No matter Modern medical therapy acne, with gonadal hormone and antibiotic for key agents, is topical agent or oral preparations, all exist cure the symptoms, not the disease, curative effect is lasting, the easy defect such as repeatedly, and side effect is larger.For this reason, people be badly in need of a kind of can treat menoxenia again can the Chinese medicine of simultaneously Acne treatment.
Summary of the invention
Not thorough for the curative effect for the treatment of menalgia companion acne existence for solving existing method, side effect is many, impact is large, doublely can not control the problem such as acne and dysmenorrhoea disease, inventor on secret prescription handed down in the family from generation to generation basis in conjunction with modern pharmacy, hammer away, meticulous compatibility, adopt modern crafts, provide a kind of pharmaceutical composition for the treatment of primary dysmenorrhea companion acne, its have dispersing the stagnated live-QI to relieve the stagnation of QI, blood stasis-eliminating and stagnation-dissipating, heat-clearing and toxic substances removing, nourishing yin and purging fire, nourish blood and blood, Chong and Ren Meridians regulating effect, be particularly useful for congestion of the liver pattern of fever dysmenorrhea companion patients with acne.
For achieving the above object, the present invention adopts following technical scheme: a kind of pharmaceutical composition for the treatment of primary dysmenorrhea companion acne, it is that medicinal raw material is made by Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Smilacis Glabrae, Folium Mahoniae, Radix Phyllagathis fordii, Rhizoma Imperatae, Radix Puerariae, Radix Glycyrrhizae.
Although the indivedual single medicinal materials in prescription of the present invention have the effect for the treatment of dysmenorrhea or acne, be all not enough to that there is good clinical therapeutic efficacy.In order to increase the coordinated effect between each raw material further, inventor is from improving curative effect of medication, reducing the angle of side effect, through screening Chinese medicine ingredients, optimize following technical scheme: a kind of pharmaceutical composition for the treatment of primary dysmenorrhea companion acne, it is by the medicinal raw material elaborate of following weight: Rhizoma Cyperi 10-20 part, Radix Curcumae 10-20 part, Rhizoma Chuanxiong 5-9 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Pericarpium Citri Reticulatae 5-15 part, Rhizoma Smilacis Glabrae 20-40 part, Folium Mahoniae 20-30 part, Radix Phyllagathis fordii 15-30 part, Rhizoma Imperatae 8-18 part, Radix Puerariae 10-15 part, Radix Glycyrrhizae 6-9 part.
Further preferably, treat a pharmaceutical composition for primary dysmenorrhea companion acne, it is by the medicinal raw material elaborate of following weight: Rhizoma Cyperi 13-18 part, Radix Curcumae 12-17 part, Rhizoma Chuanxiong 5-9 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Pericarpium Citri Reticulatae 8-13 part, Rhizoma Smilacis Glabrae 30-36 part, Folium Mahoniae 25-30 part, Radix Phyllagathis fordii 20-25 part, Rhizoma Imperatae 10-15 part, Radix Puerariae 10-15 part, Radix Glycyrrhizae 6-9 part.
Further preferably, treat a pharmaceutical composition for primary dysmenorrhea companion acne, it is by the medicinal raw material elaborate of following weight: Rhizoma Cyperi 15 parts, Radix Curcumae 15 parts, Rhizoma Chuanxiong 7 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Smilacis Glabrae 35 parts, Folium Mahoniae 25 parts, Radix Phyllagathis fordii 25 parts, Rhizoma Imperatae 12 parts, Radix Puerariae 12 parts, 8 parts, Radix Glycyrrhizae.
Chinese medicine thinks that the etiology and pathogenesis of primary disease is that ferritic sun heat is partially contained, and phlegm-damp is heavier, adds the liver failing to maintain the normal flow of QI, strongly fragrant and heat-transformation, and damage punching is appointed, so that stagnation of QI and blood may bring about pain, with the passing of time QI and blood stasis, and blood stasis and phlegm-damp are handed over and hindered, and pents up the hair powder in pustule on the face skin and stings." Complete Effective Prescriptions for Women " says: " because of through uncomfortable and sick he, regulating menstruation in the ban, through adjusting then his sick spontaneous recovery." inventor on secret prescription handed down in the family from generation to generation basis in conjunction with the body constitution of modern; provide a kind of treat primary dysmenorrhea companion acne pharmaceutical composition; be made up of Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Smilacis Glabrae, Folium Mahoniae, Radix Phyllagathis fordii, Rhizoma Imperatae, Radix Puerariae, Radix Glycyrrhizae; be used for the treatment of primary dysmenorrhea companion acne, be particularly useful for congestion of the liver pattern of fever primary dysmenorrhea companion patients with acne.Fang Zhong: the pungent row hardship of Rhizoma Cyperi is fallen, soothing the liver promoting QI circulation for relieving depression, and enter three burnt menstruction regulating and pain relievings, Radix Curcumae enters blood removing heat from blood, regulating qi to disperse stagnation, bitter cold pathogenic fire reducing; Two medicine 5 dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat and cooling blood, regulating qi to disperse stagnation, for controlling the key medicine of stagnation of QI due to depression of the liver heat-transformation.The bitter sweet temperature of the Rhizoma Atractylodis Macrocephalae, invigorating the spleen and benefiting QI, dampness diuretic, Rhizoma Smilacis Glabrae is sweet light flat, and dampness removing reduces phlegm and internal heat, and can enter network, searches to pick and damp and hot accumulates poison, Pericarpium Citri Reticulatae toil temperature, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Three medicine compatibilities, spleen reinforcing stomach invigorating, drying dampness to eliminate phlegm eliminating stagnation, the Tuoli skin ulcer that disappears is ministerial drug.Folium Mahoniae clearing away heat and nourishing YIN, suppressing the hyperactive liver kidney tonifying; Radix Phyllagathis fordii blood stasis dispelling is active, antiinflammatory is stimulated the menstrual flow, two medicine 5 nourishing blood for regulating menstruation; Rhizoma Chuanxiong warm in nature can in and the property of medicine of monarch drug, principal drug assistance blood-activating and qi-promoting, wind-expelling pain-stopping, Rhizoma Imperatae is sweet spleen reinforcing can not violate stomach, promoting the production of body fluid for nourishing the lung, and upper purgation sun heat extraction, is adjuvant drug.Radix Puerariae expelling pathogenic factors from muscles for reducing heat, priming is up to be entered to show, and is adjuvant.Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for making medicine.All medicines, combined into it, are played dispersing the stagnated live-QI to relieve the stagnation of QI, blood stasis-eliminating and stagnation-dissipating, heat-clearing and toxic substances removing, nourishing yin and purging fire altogether, are nourished blood and effect of blood, Chong and Ren Meridians regulating pain relieving, within support the outer skin ulcer that disappears.
The pharmaceutical research present situation of the present invention's each medicinal raw material used is as follows:
Rhizoma Cyperi: [nature and flavor] pungent, micro-hardship, micro-sweet, flat.[return through] returns liver, spleen, tri-jiao channel.[function cures mainly] promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Radix Curcumae: [nature and flavor] are pungent, bitter, cold.[return through] returns liver, the heart, lung meridian.[function cures mainly] regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine." Bencao Jingshu ": " Radix Curcumae originally enters the gas medicine of blood system, and it is controlled and goes up all blood disorder persons, is just calling the up of blood, all belongs to interior showing tremendous enthusiasm inflammation, this medicine energy sending down the abnormal ascending QI, and namely gas falls is that fire falls, and general character enters blood system, therefore can fall fire of moxibustion, then the not absurd row of blood.”
Rhizoma Chuanxiong: [nature and flavor] are pungent, temperature.[return through] returns liver, gallbladder, pericardium channel.[function cures mainly] blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Folium Mahoniae: [nature and flavor] are bitter; Cool.[return through] liver; Kidney channel.[function cures mainly] clearind deficient heat; Liver and kidney tonifying; Wind-damp dispelling.Main hectic fever due to deficiency of YIN; Cough spitting of blood; Have a dizzy spell; Soreness of the waist and knees; Rheumatic arthralgia; Vitiligo.
Radix Phyllagathis fordii: [nature and flavor] mildly bitter flavor; Sweet; Cool in nature.[return through] returns liver; The heart; Urinary bladder channel.[function cures mainly] nourishing blood for regulating menstruation.Main blood deficiency and yellow complexion; Menoxenia; Amenorrhea; Dysmenorrhea; Leukorrhagia.[usage and dosage] takes orally: decoct soup, 15-30g.External: appropriate, smashes deposited; Or decoct soup and wash.
The Rhizoma Atractylodis Macrocephalae: [nature and flavor] are bitter, sweet, temperature.[return through] returns spleen, stomach warp.[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Pericarpium Citri Reticulatae: [nature and flavor] are bitter, pungent, temperature.[return through] returns lung, spleen channel.[function cures mainly] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Rhizoma Smilacis Glabrae: [nature and flavor] are sweet light; Flat.[return through] liver; Stomach; Spleen channel.[function cures mainly] removing damp-heat; Let out turbid removing toxic substances; Easing joint movement.Main prunus mume (sieb.) sieb.et zucc. poison; Stranguria with turbid discharge; Have loose bowels; Muscles and bones spasm and pain; Foot gas; Carbuncle; Skin ulcer tinea; Scrofula; Goiter and mercurialism." book on Chinese herbal medicine justice ": Rhizoma Smilacis Glabrae, dampness removing reduces phlegm and internal heat, and can enter network, searches to pick and damp and hot accumulates poison.
Rhizoma Imperatae: [nature and flavor] are sweet, cold.[return through] returns lung, stomach, urinary bladder channel.[function cures mainly] cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.
Radix Puerariae: [nature and flavor] are sweet; Pungent; Flat.[return through] spleen; Stomach; Lung; Urinary bladder channel.[function cures mainly] expelling pathogenic factors from muscles for reducing heat; Deliver and examine; Promoting the production of body fluid to quench thirst; Yang invigorating antidiarrheal.Main fever caused by exogenous pathogens; Rigidity pain on the head and nape; Measles from the beginning of; Rash goes out not smooth; Epidemic febrile disease is thirsty; Diabetes; Have loose bowels; Dysentery; Hypertension; Coronary heart disease.
Radix Glycyrrhizae: [nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
In order to express Chinese medicine preparation of the present invention better, Chinese medicine preparation of the present invention is active component by Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Smilacis Glabrae, Folium Mahoniae, Radix Phyllagathis fordii, Rhizoma Imperatae, Radix Puerariae, Radix Glycyrrhizae or its water or its extractive with organic solvent, adds medicine acceptable carrier and be prepared from.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.
Further preferably, Chinese medicine preparation of the present invention is peroral dosage form, as: soft capsule, capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum.
Further preferably.Chinese medicine preparation of the present invention is tablet, capsule or granule, most preferably capsule.
Chinese medicine preparation of the present invention, applicable medicine acceptable carrier is optionally added when being prepared into medicament, described medicine acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
The present inventor also finds under study for action, by optimized fabrication method, and can when remaining valid medicine, remove impurity or the part without drug effect, reduce impurity to the interference of therapeutic effect, make this Chinese medicine preparation more effective, and reduce the consumption of medicine thus.Present invention also offers a kind of method preparing the Chinese medicine preparation for the treatment of primary dysmenorrhea companion acne, the method comprises the following steps:
Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae are added the ethanol extraction secondary of 75%-80%, each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction, by the Rhizoma Atractylodis Macrocephalae, Rhizoma Smilacis Glabrae, Folium Mahoniae, Radix Phyllagathis fordii, Rhizoma Imperatae, Radix Puerariae, Radix Glycyrrhizae is together with Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae ethanol extraction filtering residue decocts with water secondary, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content reach 50%, 12 hours are left standstill in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, pulverize rear and Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae ethanol extraction mixes, this composition is independent or mix with medicine acceptable carrier, Chinese medicine preparation of the present invention is made according to galenic pharmacy routine techniques.
Preparation of the present invention is in use according to the situation determination usage and dosage of patient.Preparation of the present invention according to the situation determination usage and dosage of patient, can take 1-3 time in use every day, each 1-20 agent, as: 1-20 bag or grain or sheet.
The present invention is that inventor is in the process for the treatment of menalgia companion acne, through repeatedly studying, progressively improve, the good Chinese medicine preparation of last successful a kind of curative effect, theoretical according to menstrual cycle, from the yang blood and qi of entirety adjustment female organism, to reach the object of effecting a permanent cure, demonstrate Chinese medicine preparation curative effect of the present invention further by clinical case, particulars is as described below:
1 data and method
1.1 physical data: observe go to a doctor year March in March, 2013 to 2014 in my institute's Out-patient Clinic of Department of Gynecology be diagnosed as primary dysmenorrhea (stagnation of liver-QI heat in blood) merge facial acne patient 108 example, 18 ~ 37 years old age, married 36 examples, unmarried 72 examples, the course of disease is the shortest 5 months, the longest 6 years.Be divided into treatment group 54 example at random, matched group 54 example, two groups of physical data, through statistical procedures difference nonsignificance (P > 0.05), have comparability.
1.2 diagnostic criteria
1.2.1 dysmenorrhea diagnostic criteria
1.2.1.1 dysmenorrhea Western medicine diagnose standard: with reference to doctor trained in Western medicine higher medical institution state-compiled textbook " obstetrics and gynecology " (sixth version), women is expert at and occurs hypogastralgia, falling inflation through front and back or menstrual phase, companion's soreness of waist or other discomforts, degree has a strong impact on live and work quality, and genitals is called dysmenorrhea without organic disease person on inspection.Be more common in unmarried or do not educate women.
1.2.1.2 dysmenorrhea tcm diagnosis standard and standards of grading: with reference to " the new Chinese medicine guideline of clinical investigations " of bureau of drug administration of Ministry of Health of the People's Republic of China formulation in 1993, draft in conjunction with the related content of dysmenorrhea in regular higher education Chinese medicine class programming textbook " Gynecology of Chinese Medicine " (sixth version).
Dysmenorrhea is defined as women all menstrual period or premenstrual through after (within 1 week) occur that periodically hypogastralgia is primary symptom, uncomfortable with other, so that affect work and give birth to reviver.
Dysmenorrhea symptom score standard: patient with lower abdominal distention pain, is therefore that this arranges basic mark 5 points before and after menstrual period; Stomachache 1 point unbearably; Suffer from abdominal pain obvious 0.5 point; Feel restless 1 point; Faint 2 points; Bitter taste in the mouth and dry throat 0.5 point; Flushing conjunctival congestion 1 point; Vexed 1 point of fullness in the chest and hypochondrium; 1 point need be lain up; Affect work and study 1 point; 1 point is not alleviated by general pain relieving measure pain; With general pain relieving measure pain relief 0.5 point; Companion's waist aches 0.5 point; Companion's nausea and vomiting 0.5 point; Companion's rectal tenesmus or diarrhoea 0.5 point; Pain is 0.5 point (often add one day and add 0.5 point) within one day.Therefore following three kinds of degree can be divided into: mild integration is below 8 points; Moderate symptoms integration is at 8 points-13.5 points; Severe symptomatic integration is more than 14 points.
1.2.2 facial acne diagnostic criteria
1.2.2.1 the Western medicine diagnose standard of facial acne
Facial acne is with reference to the diagnostic criteria of " research of the new Chinese medicine clinical guidance " acne vulgaris implemented for 2002 with reference to Ministry of Health of the People's Republic of China: pubarche falls ill, and is apt to occur in the flourishing position of the sebaceous gland such as face, upper breast and back, symmetrical.Skin lesion is pityriasis rubra pimple, blackhead, fester, tuberosity, cyst and cicatrix, with seborrhea, in chronic process.
1.2.2.2 the tcm diagnosis standard of facial acne: the diagnostic criteria of " tcm clinical practice disease Standardization of diagnosis and curative effect " traditional Chinese medical science acne that State Administration of Traditional Chinese Medicine issues for 1994 is drafted:
At follicular orifice, present small rice grain size red papules, then form pus, scleroma sample white acne or blackhead, even can form scleroma property cyst; The face of adolescence men and women, often with seborrhea; Female patient is many with menoxenia.
1.2.2.3 skin ulcer of fullying recover from an illness severity Scaling and standards of grading: with reference to " acne vulgaris classification of severity and curative effect determinate standard " that in October, 1997, medical cosmetology branch of China beautifying skin group was formulated, acne vulgaris is divided into 3 degree nine grades, drafts scoring as follows:
Slight: 1 grade: to be less than 25,1 point; 2 grades 26-50,2 points; 3 grades 51-75,3 points
Moderate: 1 grade: 76-100,4 points; 2 grades more than 100,5 points; 3 grades with l-2 tuberosity or cyst, 6 points
Severe: 1 grade with 3-5 tuberosity or cyst, 7 points; 2 grades, with 6 with inferior thyroid tubercle or cyst, 8 points; 3 grades, with tuberosity, cyst and hypertrophica paralysed trace or sinus tract, 9 points.
Note: the position choosing of skin lesion counting is right or left side is facial, demarcates with centrage, comprises half side forehead, cheekbone portion, buccal, neck portion, the calculating of neck portion summation.After treatment, if all disappearances, it is 0 point.If be still simple after treatment, but alleviate to some extent, then can calculate little point, often improvement 10% can deduct 0.1 point.Inactivity pathological changes (comprising pigmentation, hole point-like paralysis trace) does not make Scoring Index.
1.3 case selection standards
1.3.1 case standard is included in:
Meet the western medicine universities standard of primary dysmenorrhea and common skin ulcer of fullying recover from an illness; Meet the diagnostic criteria of traditional Chinese medical science primary dysmenorrhea and congestion of the liver pattern of fever CM syndrome differentiation criterion.
1.3.2 Excluded cases standard:
Secondary dysmenorrhea person caused by the pathological changes such as pelvic inflammatory disease, sub-official's endometrium ectopia, hysteromyoma, adenomyosis; Be associated with the severe primary diseases such as cardiovascular, liver, kidney and hemopoietic system, or psychotic; Allergic constitution person (referring to two or more medicines or food allergy or irritated to the own principal component of this test medication); The Drug that occupational acne or iodine, bromine etc. cause is fullyed recover from an illness skin ulcer; Participating in the patient of other clinical trials; Do not meet inclusive criteria, not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person.
1.4 Therapeutic Method: treatment group: capsule prepared by the embodiment of the present invention 1, started to take at premenstrual 3 days, serve on 7 days, not drug withdrawal in menstrual period, once take 2-4 grain, one day 2 times, continuous use 3 menstrual cycle are a course for the treatment of;
Matched group: danzhi xiaoyao pills, each 6-9g, treatment 3 menstrual cycle were 1 course for the treatment of continuously.
Two groups of patients all do not take other drug at treatments period, patient to explain's state of an illness, eliminate patients ' psychological misgivings, advise patient mental optimistic, appropriate level of work and rest, avoid eating anything raw or cold and pungent.
1.5 observation index:
1.5.1 safety observations: general health check-up project; Blood, urine routine test, Liver and kidney function inspection, respectively looks into once before and after treatment;
1.5.2 health giving quality observation: pain degree and persistent period, respectively records once before and after medication and after each menstrual cycle of medication; Menstrual phase amount, color, matter and simultaneous phenomenon and the change of tongue arteries and veins, respectively record once before and after medication and after each menstrual cycle of medication;
1.5.3 each premenstrua facial acne situation record before and after medication;
After terminating the course for the treatment of, following up a case by regular visits to of 3 menstrual cycle is by a definite date carried out to two groups of patients.
1.6 curative effect determinate standard
1.6.1 dysmenorrhea curative effect determinate standard: " guideline of clinical investigations of new Chinese medicine treatment dysmenorrhea " issued according to bureau of drug administration of Ministry of Health of the People's Republic of China is formulated: recovery from illness: abdominal pain in menstruation and other transference cures after taking medicine, drug withdrawal 3 non-recidivists of menstrual cycle; Effective: stomachache obviously alleviates, all the other symptoms take a turn for the better, and drug withdrawal 3 menstrual cycle symptoms do not increase the weight of; Effective: stomachache alleviates, other symptoms take a turn for the better, though symptom repeatedly, comparatively alleviates before treatment after drug withdrawal; Invalid: stomachache and other symptoms are without change or add severe one.
1.6.2 acne curative effect determinate standard judges according to integration method: therapeutic index: (before treating the rear integration of integration-treatment)/treat front integration * 100%.Recovery from illness: skin lesion therapeutic index > 95%, subjective symptoms disappears; Effective: 60% < skin lesion therapeutic index < 95%, subjective symptoms is obviously improved; Effective: 20% < skin lesion therapeutic index < 60%, subjective symptoms makes moderate progress; Invalid: skin lesion therapeutic index < 20%, or counter see increase, subjective symptoms is without improvement.
1.7 statistical methods: adopt SPSS16.0 statistical software to calculate.Each numerical value with
represent, measurement data adopts t inspection, and enumeration data adopts χ
2inspection, with P < 0.05 for difference has statistical significance.
2 results
2.1 liang of group dysmenorrhea treatment effectiveness comparison: treatment group recovery from illness 33 example, effective 13 examples, take a turn for the better 8 examples, invalid 0 example, obvious effective rate 85.2%, total effective rate 100%; Matched group recovery from illness 10 example, effective 13 examples, take a turn for the better 17 examples, invalid 14 examples, obvious effective rate 42.6%, total effective rate 74.1%, treatment group obvious effective rate, total effective rate are apparently higher than matched group, and difference has statistical significance (P < 0.05).Concrete outcome is in table 1.
Table 1 liang group dysmenorrhea treatment effectiveness comparison, example
Dysmenorrhea integral contrast before and after 2.2 treatments: the dysmenorrhea integration no significant difference (P > 0.05) for the treatment of front two groups of patients, has comparability.Treatment after two groups comparatively treat before all have statistical significance (P < 0.01).After treatment, between two groups of groups, comparing difference has statistical significance (P < 0.05), and namely treatment group effect is more obvious.In table 2.
Table 2 treatment front and back dysmenorrhea integral contrast (
point)
Note: compare with before treatment: * P < 0.01; Compare between two groups after treatment:
#p < 0.05.
Before and after 2.3 liang of group patient treatments, acne severity Scaling compares: before and after treatment group treatment, acne integration has significant difference (P < 0.01), there was no significant difference (P > 0.05) before and after treatment of control group, and after two groups of treatments, integral contrast has significant difference (P < 0.01), illustrates that treatment group improves significantly to acne.In table 3.
Before and after table 3 liang group patient treatment acne severity Scaling compare (
point)
Note: compare with before treatment: * P < 0.01; Compare between two groups after treatment:
#p < 0.01.
Acne comparitive study before and after 2.4 liang of group patient treatments: treatment group recovery from illness 6 example, effective 17 examples, take a turn for the better 22 examples, no effect 9, obvious effective rate 42.6%, total effective rate 83.3%; Matched group recovery from illness 0 example, effective 2 examples, take a turn for the better 8 examples, and invalid 44 examples, obvious effective rate 3.7%, total effective rate 18.5%, treatment group obvious effective rate, total effective rate are apparently higher than matched group, and difference has statistical significance (P < 0.01).Concrete outcome is in table 4.
Acne comparitive study before and after table 4 liang group patient treatment, example
2.5 safety evaluatios: after treatment group patient takes, to routine blood test, routine urinalysis, the safety indexes such as Liver and kidney function detect and have no impact, are showed no untoward reaction generation between treatments period and follow-up period.
To sum up we can find out, two groups are compared with on obvious effective rate at dysmenorrhea total effects, and treatment group is apparently higher than matched group, and difference has statistical significance (P < 0.05); Two groups of patient's dysmenorrhea integral contrasts, after each group for the treatment of, dysmenorrhea integration all has significant differences (P < 0.01), and between latter two groups for the treatment of, dysmenorrhea integration has compared significant difference (P < 0.05), illustrates that treatment group effect is more obvious.
In relatively acne classification, before and after treatment group treatment, acne integration has significant difference (P < 0.01) according to zero difference (P > 0.05) before and after group treatment, and after two groups of treatments, integral contrast has significant difference (P < 0.01), illustrates that treatment group improves significantly to acne.Through two groups of patient facial region's acne clinical curative effect analysis, between treatment group and matched group curative effect, there is significant difference (P < 0.01).This absolutely proves that the overall curative effect for the treatment of group in treatment dysmenorrhea is better than matched group, and the facial acne for the treatment of group patient obtains obvious improvement, and matched group has no improvement in acne.Therefrom can find out that the dialectical treatment of the traditional Chinese medical science is not simple symptomatic treatment, but overall assurance, dialectical treatment, therefore in the process for the treatment of dysmenorrhea, acne is also improved simultaneously, kills two birds with one stone.Safety testing result, blood before and after treatment group treatment, routine urinalysis, hepatic and renal function change all without exception, shows that treatment group medicine used is without obvious toxic-side effects, safe and reliable.
In a word, compared with prior art, the present invention has following beneficial effect:
Selected by invention medicine, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, legislation comprehensively, medication is thoughtful, play dispersing the stagnated live-QI to relieve the stagnation of QI altogether, blood stasis-eliminating and stagnation-dissipating, heat-clearing and toxic substances removing, nourishing yin and purging fire, nourish blood and effect of blood, for the etiology and pathogenesis factor of primary dysmenorrhea companion acne, play Chinese medicine preparation Mutiple Targets of the present invention, too many levels, multi-level comprehensive regulation effect, link up up and down, clinical efficacy is definite, side effect is less, patient compliance is better, taking convenience, can effectively alleviate patient's burden and misery, the object for the treatment of both the principal and secondary aspects of a disease can be reached, wide popularization and application on clinic.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: Rhizoma Cyperi 15 parts, Radix Curcumae 15 parts, Rhizoma Chuanxiong 7 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Smilacis Glabrae 35 parts, Folium Mahoniae 25 parts, Radix Phyllagathis fordii 25 parts, Rhizoma Imperatae 12 parts, Radix Puerariae 12 parts, 8 parts, Radix Glycyrrhizae.
Preparation method: ethanol extraction secondary Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae being added 75%-80%, each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction, by the Rhizoma Atractylodis Macrocephalae, Rhizoma Smilacis Glabrae, Folium Mahoniae, Radix Phyllagathis fordii, Rhizoma Imperatae, Radix Puerariae, Radix Glycyrrhizae is together with Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae ethanol extraction filtering residue decocts with water secondary, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content reach 50%, 12 hours are left standstill in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, dry, pulverize rear and Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae ethanol extraction mixes, capsule is made according to galenic pharmacy routine techniques, every containing crude drug 1.76g.
Embodiment 2
Prescription: Rhizoma Cyperi 13 parts, Radix Curcumae 15 parts, Rhizoma Chuanxiong 8 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Pericarpium Citri Reticulatae 8 parts, Rhizoma Smilacis Glabrae 30 parts, Folium Mahoniae 30 parts, Radix Phyllagathis fordii 20 parts, Rhizoma Imperatae 10 parts, Radix Puerariae 15 parts, 8 parts, Radix Glycyrrhizae.
Preparation method: carry out with reference to embodiment 1.
Embodiment 3
Prescription: Rhizoma Cyperi 15 parts, Radix Curcumae 12 parts, Rhizoma Chuanxiong 5 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Pericarpium Citri Reticulatae 8 parts, Rhizoma Smilacis Glabrae 36 parts, Folium Mahoniae 25 parts, Radix Phyllagathis fordii 20 parts, Rhizoma Imperatae 12 parts, Radix Puerariae 10 parts, 6 parts, Radix Glycyrrhizae.
Preparation method: carry out with reference to embodiment 1.
Embodiment 4
Prescription: Rhizoma Cyperi 18 parts, Radix Curcumae 15 parts, Rhizoma Chuanxiong 9 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Pericarpium Citri Reticulatae 12 parts, Rhizoma Smilacis Glabrae 30 parts, Folium Mahoniae 30 parts, Radix Phyllagathis fordii 22 parts, Rhizoma Imperatae 15 parts, Radix Puerariae 10 parts, 7 parts, Radix Glycyrrhizae.
Preparation method: carry out with reference to embodiment 1.
Embodiment 5
Prescription: Rhizoma Cyperi 13 parts, Radix Curcumae 18 parts, Rhizoma Chuanxiong 8 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Pericarpium Citri Reticulatae 15 parts, Rhizoma Smilacis Glabrae 40 parts, Folium Mahoniae 20 parts, Radix Phyllagathis fordii 30 parts, Rhizoma Imperatae 10 parts, Radix Puerariae 12 parts, 8 parts, Radix Glycyrrhizae.
Preparation method: carry out with reference to embodiment 1.
Embodiment 6
Prescription: Rhizoma Cyperi 16 parts, Radix Curcumae 16 parts, Rhizoma Chuanxiong 8 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Pericarpium Citri Reticulatae 5 parts, Rhizoma Smilacis Glabrae 20 parts, Folium Mahoniae 25 parts, Radix Phyllagathis fordii 25 parts, Rhizoma Imperatae 15 parts, Radix Puerariae 10 parts, 8 parts, Radix Glycyrrhizae.
Preparation method: carry out with reference to embodiment 1.
Embodiment 7
Prescription: Rhizoma Cyperi 20 parts, Radix Curcumae 20 parts, Rhizoma Chuanxiong 9 parts, the Rhizoma Atractylodis Macrocephalae 17 parts, Pericarpium Citri Reticulatae 12 parts, Rhizoma Smilacis Glabrae 30 parts, Folium Mahoniae 28 parts, Radix Phyllagathis fordii 20 parts, Rhizoma Imperatae 8 parts, Radix Puerariae 14 parts, 8 parts, Radix Glycyrrhizae.
Preparation method: carry out with reference to embodiment 1.
Embodiment 8
Prescription: Rhizoma Cyperi 15 parts, Radix Curcumae 15 parts, Rhizoma Chuanxiong 7 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Smilacis Glabrae 35 parts, Folium Mahoniae 25 parts, Radix Phyllagathis fordii 25 parts, Rhizoma Imperatae 12 parts, Radix Puerariae 12 parts, 8 parts, Radix Glycyrrhizae.
Preparation method: ethanol extraction secondary Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae being added 75%-80%, each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction; The Rhizoma Atractylodis Macrocephalae, Rhizoma Smilacis Glabrae, Folium Mahoniae, Radix Phyllagathis fordii, Rhizoma Imperatae, Radix Puerariae, Radix Glycyrrhizae are decocted with water secondary together with Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae ethanol extraction filtering residue, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content reach 50%, 12 hours are left standstill in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, dry, pulverize after and Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae ethanol extraction mix, make tablet according to galenic pharmacy routine techniques.
Embodiment 9
Prescription: Rhizoma Cyperi 15 parts, Radix Curcumae 15 parts, Rhizoma Chuanxiong 7 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Smilacis Glabrae 35 parts, Folium Mahoniae 25 parts, Radix Phyllagathis fordii 25 parts, Rhizoma Imperatae 12 parts, Radix Puerariae 12 parts, 8 parts, Radix Glycyrrhizae.
Preparation method: ethanol extraction secondary Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae being added 75%-80%, each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction; The Rhizoma Atractylodis Macrocephalae, Rhizoma Smilacis Glabrae, Folium Mahoniae, Radix Phyllagathis fordii, Rhizoma Imperatae, Radix Puerariae, Radix Glycyrrhizae are decocted with water secondary together with Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae ethanol extraction filtering residue, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content reach 50%, 12 hours are left standstill in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, dry, pulverize after and Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae ethanol extraction mix, make granule according to galenic pharmacy routine techniques.
Embodiment 10
Prescription: Rhizoma Cyperi 15 parts, Radix Curcumae 15 parts, Rhizoma Chuanxiong 7 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Smilacis Glabrae 35 parts, Folium Mahoniae 25 parts, Radix Phyllagathis fordii 25 parts, Rhizoma Imperatae 12 parts, Radix Puerariae 12 parts, 8 parts, Radix Glycyrrhizae.
Preparation method: ethanol extraction secondary Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae being added 75%-80%, each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction; The Rhizoma Atractylodis Macrocephalae, Rhizoma Smilacis Glabrae, Folium Mahoniae, Radix Phyllagathis fordii, Rhizoma Imperatae, Radix Puerariae, Radix Glycyrrhizae are decocted with water secondary together with Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae ethanol extraction filtering residue, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content reach 50%, 12 hours are left standstill in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, dry, pulverize after and Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae ethanol extraction mix, make oral liquid according to galenic pharmacy routine techniques.
Claims (10)
1. treat a pharmaceutical composition for primary dysmenorrhea companion acne, it is characterized in that by Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Smilacis Glabrae, Folium Mahoniae, Radix Phyllagathis fordii, Rhizoma Imperatae, Radix Puerariae, Radix Glycyrrhizae be that medicinal raw material is made.
2. pharmaceutical composition as claimed in claim 1, is characterized in that by the medicinal raw material elaborate of following weight: Rhizoma Cyperi 10-20 part, Radix Curcumae 10-20 part, Rhizoma Chuanxiong 5-9 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Pericarpium Citri Reticulatae 5-15 part, Rhizoma Smilacis Glabrae 20-40 part, Folium Mahoniae 20-30 part, Radix Phyllagathis fordii 15-30 part, Rhizoma Imperatae 8-18 part, Radix Puerariae 10-15 part, Radix Glycyrrhizae 6-9 part.
3. pharmaceutical composition as claimed in claim 2, is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Rhizoma Cyperi 13-18 part, Radix Curcumae 12-17 part, Rhizoma Chuanxiong 5-9 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Pericarpium Citri Reticulatae 8-13 part, Rhizoma Smilacis Glabrae 30-36 part, Folium Mahoniae 25-30 part, Radix Phyllagathis fordii 20-25 part, Rhizoma Imperatae 10-15 part, Radix Puerariae 10-15 part, Radix Glycyrrhizae 6-9 part.
4. pharmaceutical composition as claimed in claim 3, is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Rhizoma Cyperi 15 parts, Radix Curcumae 15 parts, Rhizoma Chuanxiong 7 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Smilacis Glabrae 35 parts, Folium Mahoniae 25 parts, Radix Phyllagathis fordii 25 parts, Rhizoma Imperatae 12 parts, Radix Puerariae 12 parts, 8 parts, Radix Glycyrrhizae.
5. the pharmaceutical composition as described in as arbitrary in claim 1-4, is characterized in that described pharmaceutical composition is peroral dosage form.
6. pharmaceutical composition as claimed in claim 5, is characterized in that described peroral dosage form is soft capsule, capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum.
7. pharmaceutical composition as claimed in claim 6, is characterized in that described peroral dosage form is preferably tablet, capsule or granule.
8. pharmaceutical composition as claimed in claim 7, is characterized in that described peroral dosage form is capsule.
9. the pharmaceutical composition as described in as arbitrary in claim 1-8, it is characterized in that the preparation method of described pharmaceutical composition comprises the following steps: ethanol extraction secondary Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae being added 75%-80%, each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction, by the Rhizoma Atractylodis Macrocephalae, Rhizoma Smilacis Glabrae, Folium Mahoniae, Radix Phyllagathis fordii, Rhizoma Imperatae, Radix Puerariae, Radix Glycyrrhizae is together with Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae ethanol extraction filtering residue decocts with water secondary, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content reach 50%, 12 hours are left standstill in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract, pulverize rear and Rhizoma Cyperi, Radix Curcumae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae ethanol extraction mixes, this composition is independent or mix with medicine acceptable carrier, Chinese medicine preparation of the present invention is made according to galenic pharmacy routine techniques, as soft capsule, capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum, etc..
10. the application of the arbitrary described pharmaceutical composition of claim 1-9 in the medicine of preparation treatment congestion of the liver pattern of fever dysmenorrhea companion acne.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103386086A (en) * | 2013-07-21 | 2013-11-13 | 黄淑娟 | Traditional Chinese medicine composition for treating dysmenorrhea and preparation method thereof |
| CN104784573A (en) * | 2015-04-27 | 2015-07-22 | 中国人民解放军总医院 | Traditional Chinese medicine decoction formula for treating female acne concomitant with irregular menstruation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103386086A (en) * | 2013-07-21 | 2013-11-13 | 黄淑娟 | Traditional Chinese medicine composition for treating dysmenorrhea and preparation method thereof |
| CN104784573A (en) * | 2015-04-27 | 2015-07-22 | 中国人民解放军总医院 | Traditional Chinese medicine decoction formula for treating female acne concomitant with irregular menstruation |
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| Title |
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| 孙葳等: "丹栀逍遥散加减治疗痤疮60例", 《吉林中医药》 * |
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