CN105288493A - Method for preparing traditional Chinese medicine preparation capable of treating schizophrenia - Google Patents
Method for preparing traditional Chinese medicine preparation capable of treating schizophrenia Download PDFInfo
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- CN105288493A CN105288493A CN201510858783.1A CN201510858783A CN105288493A CN 105288493 A CN105288493 A CN 105288493A CN 201510858783 A CN201510858783 A CN 201510858783A CN 105288493 A CN105288493 A CN 105288493A
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Abstract
The invention discloses a method for preparing a traditional Chinese medicine preparation capable of treating schizophrenia, belonging to the technical field of traditional Chinese medicine. The method for preparing the traditional Chinese medicine preparation capable of treating schizophrenia comprises the steps of respectively performing treatment on raw materials such as snakegourd fruit, radix pseudostellariae, magnetite, coptidis rhizome, acorus calamus, curcuma aromatica, oyster, polygala tenuifolia, fresh radix phytolaccae, white paeony root, poria with hostwood, raw rhubarb, chrysoidine, gentian, peach kernel, mirabilite, cortex albiziae, radix scutellariae, caulis akebiae, bile arisaema and radix liquiritiae, mixing, filtering, concentrating, adding excipients, so as to obtain a traditional Chinese medicine finished product preparation clinically required. The traditional Chinese medicine preparation prepared by the method has the obvious technical advantages that the curative effect is good, effect of medicine is mild, recuperating under medical treatment is realized, no toxic and side effect exists and the like in the treatment of schizophrenia, in addition, the characteristics that a preparation technology is advanced, the effect of the preparation is stable, popularization and application are suitable and the like are also the obvious technical advantages of the traditional Chinese medicine preparation.
Description
Technical field
The present invention discloses and a kind ofly prepares the method for the treatment of schizoid Chinese medicine preparation, belongs to technical field of Chinese medicines.
Background technology
Schizophrenia is the not bright major psychosis of one group of cause of disease, many person between twenty and fifty slow or subacute onset, often show as the different syndrome of symptom clinically, relate to the inharmonious of many-sided obstacles such as sensory perception, thinking, emotion and behavior and ergasia.The general Clear consciousness of patient, intelligence is normal, but some patients there will be the infringement of cognitive function in lysis.The course of disease is generally delayed, and in recurrent exerbation, increases the weight of or worsens, and decline and mental handicap finally appear in some patients, but some patients can keep recovery from illness or the state that is almost recovered after treatment.
At present, doctor trained in Western medicine mainly uses psychotolytic medicine for schizoid treatment, and these medicine side effect are very large, very large to patient injury itself, and not easily cures.
The traditional Chinese medical science thinks that the schizoid cause of disease is because feelings will is unsuccessful, damage liver spleen, or injures the mind because of excessive thinking.In addition, its morbidity has substantial connection with natural endowment and physical strength again.Pathological change is because of excessive thinking, impairment caused by overstrain heart spleen, and causes heart spleen two wound, blood failing to tonify the heart, occurs insomnia, absent minded, absentminded, cardiopalmus susceptible to get angry, grieved for crying, the diseases such as fatigue and weak.Or because of melancholy impairing the liver, depression of liver-QI, injures taste, cause insufficiency of the spleen mistake fortune, raw humidogene expectorant, mental disorder superinverse, ties in ambition, mist thinking gods, and occur that spirit is dull-witted, speaking incoherently, being happy and angry uncertainly, dirty custom is not known.The abundant expectoration folder stasis of blood, expectorant stasis of blood combined pathogens, coagulation of QI-blood, brain gas is not connected with qi of zang-fu viscera, also can cause morbidity.Schizophrenia Syndrome Differentiation of Traditional Chinese Medicine is as follows:
1, phlegm-fire confusing heart type: excited restless, lies awake all night, and vexed annoyance, swears at people, cry and laugh by turns, without any apparent reason, thing is ruined in impulsion, hears of the sound that curse is abused, photis, incoherence of speech, attention laxes, disobey, without ability of self control, red constipation of urinating, flushing, xerostomia desire for cold drinks, red tongue or fall, yellow and greasy fur or black greasy, slippery and rapid pulse is strong.Therapeutic rules: clearing heart fire, waking up the patient from unconsciousness by clearing away phlegm.
2, phlegm-damp internal resistance type: look stupid, apathy, only language is from laughing at, slow in action, passive exposure, and social competence weakens, spiritlessness and weakness, indigestion and loss of appetite loose stool, or keeps oneself to oneself and be reluctant to see people, or numb, and body of the tongue is fat has indentation greatly, white and greasy fur, rolling pulse or deep and slow.Therapeutic rules: invigorating the spleen and benefiting QI, tranquilizing by nourishing the heart.
3, qi stagnation and blood stasis type: inmature unwise, the incoherence of speech of behavior, neologism, expresses one's feelings strange, auditory hallucination photis, emotional lability, excited restless, sleep poor, cry and scream, sigh, irascible temperament, skin is coarse, dim complexion, and first Zou is obvious, the amenorrhea of aeg's dysmenorrhea, purplish tongue, sublingual varicosis, hesitant pulse or dizzy.Therapeutic rules: promoting flow of QI and blood, allays excitement and has one's ideas straightened out.
4, type of hyperactivity of fire caused by deficiency of YIN: the course of disease is longer, palpitation and restlessness, vexedly sleeps less, stirs up a disturbance dry dynamic, time have delirium, god knows unconsciousness, inflammable, and hallucination is vainly hoped, and thinking association difficulty, solitarily shrinks back, constipation with dry stool, oliguria with reddish urine, xerostomia not for drink, red and uncoated tongue, thready and rapid pulse.Therapeutic rules: nourishing YIN and clearing away heat, nourishing blood to tranquillize the mind.
5, yang deficiency loss type: apathetic expression, be in a trance, sluggishness is shunk back, and does not associate with people, shameless dirty clean, retardation of thinking and discontinuous, fragment is vainly hoped, of few words few dynamic without desire, lusterless complexion or sallow, body nihility power, social function completely loses, and pale tongue with thin fur is white, and deep pulse is unable.Therapeutic rules: warming YANG is had one's ideas straightened out.
Summary of the invention
The technical problem to be solved in the present invention is that invention a kind ofly prepares the method for the treatment of schizoid Chinese medicine preparation.For solving this technical problem, the technical scheme that inventor adopts is, first according to schizophrenia clinical experience for many years and scientific research, utilize Chinese medical theory knowledge, meticulous compatibility medical material, composition grass side, then constantly grass side to be adjusted in conjunction with the Technology of clinical practice effect and modern Chinese medicine preparation and perfect, the Chinese prescription that final invention one is brand-new and a set of preparation method matched with it, thus obtained Chinese medicine finished product preparation not only overcomes the not portable shortcoming such as to take of Chinese medicine, and treatment schizophrenia effect is very remarkable.This Chinese prescription is (with parts by weight):
Fructus Trichosanthis 12-36 part, Radix Pseudostellariae 10-30 part, Magnetitum 12-34 part, Rhizoma Coptidis 7-19 part, Rhizoma Acori Graminei 6-17 part, Radix Curcumae 7-27 part, Concha Ostreae 7-29 part, Radix Polygalae 5-16 part, fresh Radix Phytolaccae 15-53 part, Radix Paeoniae Alba 9-25 part, Poria cum Radix Pini 7-29 part, Radix Et Rhizoma Rhei 17-40 part, Exocarpium Citri Rubrum 6-19 part, Radix Gentianae 8-28 part, Semen Persicae 7-22 part, Natrii Sulfas 4-11 part, Cortex Albiziae 7-23 part, Radix Scutellariae 10-32 part, Caulis Akebiae 7-25 part, Arisaema Cum Bile 4-12 part, Radix Glycyrrhizae Preparata 6-15 part.
Further, the preferred Chinese prescription of described Chinese medicine preparation is (with parts by weight): Fructus Trichosanthis 24 parts, Radix Pseudostellariae 20 parts, Magnetitum 22 parts, Rhizoma Coptidis 13 parts, Rhizoma Acori Graminei 11 parts, Radix Curcumae 17 parts, Concha Ostreae 18 parts, Radix Polygalae 10 parts, fresh Radix Phytolaccae 34 parts, the Radix Paeoniae Alba 15 parts, Poria cum Radix Pini 17 parts, Radix Et Rhizoma Rhei 27 parts, Exocarpium Citri Rubrum 13 parts, Radix Gentianae 19 parts, 14 parts, Semen Persicae, 7 parts, Natrii Sulfas, Cortex Albiziae 14 parts, Radix Scutellariae 21 parts, Caulis Akebiae 17 parts, Arisaema Cum Bile 8 parts, Radix Glycyrrhizae Preparata 12 parts.
Further, the preferred Chinese prescription of described Chinese medicine preparation is (with parts by weight): Fructus Trichosanthis 26 parts, Radix Pseudostellariae 22 parts, Magnetitum 20 parts, Rhizoma Coptidis 14 parts, Rhizoma Acori Graminei 10 parts, Radix Curcumae 19 parts, Concha Ostreae 17 parts, Radix Polygalae 10 parts, fresh Radix Phytolaccae 38 parts, the Radix Paeoniae Alba 14 parts, Poria cum Radix Pini 18 parts, Radix Et Rhizoma Rhei 26 parts, Exocarpium Citri Rubrum 11 parts, Radix Gentianae 17 parts, 13 parts, Semen Persicae, 7 parts, Natrii Sulfas, Cortex Albiziae 17 parts, Radix Scutellariae 23 parts, Caulis Akebiae 18 parts, Arisaema Cum Bile 9 parts, Radix Glycyrrhizae Preparata 13 parts.
The present invention discloses and a kind ofly prepares the method for the treatment of schizoid Chinese medicine preparation, comprises the following steps:
(1) raw material of following weight portion is taken: Fructus Trichosanthis 12-36 part, Radix Pseudostellariae 10-30 part, Magnetitum 12-34 part, Rhizoma Coptidis 7-19 part, Rhizoma Acori Graminei 6-17 part, Radix Curcumae 7-27 part, Concha Ostreae 7-29 part, Radix Polygalae 5-16 part, fresh Radix Phytolaccae 15-53 part, Radix Paeoniae Alba 9-25 part, Poria cum Radix Pini 7-29 part, Radix Et Rhizoma Rhei 17-40 part, Exocarpium Citri Rubrum 6-19 part, Radix Gentianae 8-28 part, Semen Persicae 7-22 part, Natrii Sulfas 4-11 part, Cortex Albiziae 7-23 part, Radix Scutellariae 10-32 part, Caulis Akebiae 7-25 part, Arisaema Cum Bile 4-12 part, Radix Glycyrrhizae Preparata 6-15 part;
(2) Radix Glycyrrhizae Preparata is pulverized, levigate, cross 80-130 mesh sieve, obtain fine powder a, for subsequent use;
(3) fresh Radix Phytolaccae pulverizing is squeezed the juice, filter to obtain Radix Phytolaccae juice, for subsequent use;
(4) Fructus Trichosanthis, Magnetitum, Rhizoma Coptidis, Concha Ostreae, Radix Polygalae, the Radix Paeoniae Alba, Poria cum Radix Pini, Radix Et Rhizoma Rhei, Exocarpium Citri Rubrum, Radix Gentianae, Natrii Sulfas, Cortex Albiziae, Radix Scutellariae are pulverized and mixed respectively, add the purified water of initial medical material 6-16 times weight, soak 4-24 hour, backflow decocts 1-5 hour, filters, then adds the purified water of initial weight 4-12 times weight, backflow decocts 1-4 hour, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.20-1.23 is for subsequent use;
(5) filtering residue of Radix Pseudostellariae, Rhizoma Acori Graminei, Radix Curcumae, Semen Persicae, Caulis Akebiae, Arisaema Cum Bile and step (4) is added the ethanol of the concentration 65-85% of 5-12 times of weight, reflux, extract, 2 times, each 1-5 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.20-1.23 is for subsequent use;
(6) merged by the concentrated solution of step (3) gained Radix Phytolaccae juice and step (4) and (5) gained, continuing to be concentrated into 50 DEG C of relative densities is the Chinese medical concrete of 1.36-1.39, and vacuum drying is to dry extract, pulverize levigate, cross 80-130 mesh sieve, obtain fine powder b, for subsequent use;
(7) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make the Chinese medicine finished product preparation of clinical needs.
Further, the dosage form of described Chinese medicine preparation be decoction, pill (containing honeyed pill, the watered pill, paste pill, wax pill, concentrated pill), powder, unguentum (containing soft extract, ointment, plaster), sublimed preparation, medicated wine, syrup, extractum, lozenge, distillate medicinal water, colloid, medicinal tea, nail agent, stick, suppository, herbal leaven, paste, cake agent, wash liniment, oil preparation, line agent (medicated line), medicated roll (fuse), press agent, process agent, fumicants, tablet, tincture, capsule (containing soft capsule) or granule.
The present invention also discloses the purposes of above-mentioned Chinese medicine preparation in treatment schizophrenia.
The source of raw material of Chinese medicine medical material involved in the present invention, meridian distribution of property and flavor and effect function:
1, Fructus Trichosanthis: this product is the dry mature fruit of cucurbitaceous plant Fructus Trichosanthis or trichosanthes rosthornii Harms.Sweet in the mouth, micro-hardship, cold in nature; Return lung, stomach, large intestine channel; Clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes laxation.
2, Radix Pseudostellariae: this product is the dried root of pinkwort Radix Ginseng.Sweet in the mouth, micro-hardship, property is put down; Return spleen, lung meridian; Replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.
3, Magnetitum: this product is oxide-based mineral spinelle race magnetic iron ore, main containing ferroso-ferric oxide (Fe3O4).After excavating, except roguing stone.Salty in the mouth, cold in nature; Return liver, the heart, kidney channel; Suppressing the hyperactive liver and subsiding YANG, hearing-improing and eyesight improving, tranquillizing the mind by relieving convulsion, helping inspiration to relieve asthma.
4, Rhizoma Coptidis: this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.Bitter in the mouth, cold in nature; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication.
5, Rhizoma Acori Graminei: this product is the dry rhizome of acorus gramineus araceae plant.Acrid in the mouth, hardship, warm in nature; GUIXIN, stomach warp; Removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.
6, Radix Curcumae: this product is the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae.Acrid in the mouth, hardship, cold in nature; Return liver, the heart, lung meridian; Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.
7, Concha Ostreae: this product is the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.Salty in the mouth, cold nature; Return liver, gallbladder, kidney channel; Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.
8, Radix Polygalae: this product is the dry root of milk wort Radix Polygalae or ovum leaf Radix Polygalae.Bitter in the mouth, pungent, warm in nature; GUIXIN, kidney, lung meridian; To calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm, detumescence.
9, Radix Phytolaccae: this product is the dry root of Phytolaccaceae plant pokeweed or pokeroot.Autumn excavated to time spring, and removing fibrous root and silt, be cut into block or sheet, dry or dry in the shade.Bitter in the mouth, cold in nature; Return lung, spleen, kidney, large intestine channel; To relieve oedema or abdominal distension through diuresis or purgation detumescence, smoothening secretion, detoxicating and resolving stagnation of pathogens.
10, the Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae.Bitter in the mouth, acid, cold nature; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
11, Poria cum Radix Pini: in the middle of poria cocos sclerotium, (Poria) entertains the part of Radix Pini massonianae or fine core person.Sweet in the mouth, property are flat; Mind tranquilizing and the heart calming.
12, Radix Et Rhizoma Rhei: this product is the dry root and rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Bitter in the mouth, cold in nature; Return spleen, stomach, large intestine, liver, pericardium channel; Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.
13, Exocarpium Citri Rubrum: this product is the dry outside rind of rutaceae Huazhou Fructus Citri tangerinae or Fructus Citri tangerinae and variety thereof.Gather after time of the year when autumn changes into winter fruit maturation, cut lower outer peel with cutter, dry or dry in the shade.Acrid in the mouth, hardship, warm in nature; Return lung, spleen channel; Cold expelling, dampness, promoting the circulation of QI, expectorant.
14, Radix Gentianae: this product is the dry root and rhizome of gentianaceae plant Gentiana manshurica, Radix Gentianae, G. triflora or Gentiana rigescens Franch.Bitter in the mouth, cold in nature; Return liver, gallbladder meridian; Heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.
15, Semen Persicae: this product is the dry mature seed of rosaceous plant Fructus Persicae or Prunus davidiana.Bitter in the mouth, sweet, property is put down; GUIXIN, liver, large intestine channel; Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.
16, Natrii Sulfas: this product is Sulfates mineral Natrii Sulfas race Natrii Sulfas, through the crystalline solid of processing and refining.Salty in the mouth, hardship, cold in nature; Return stomach, large intestine channel; Purging heat to relax the bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.
17, Cortex Albiziae: this product is the dry bark of leguminous plant Herba Albiziae.Sweet in the mouth, property is put down; GUIXIN, liver, lung meridian; Resolving stagnation for tranquilization, promoting blood circulation and detumescence.
18, Radix Scutellariae: this product is the dry root of labiate Radix Scutellariae.Bitter in the mouth, cold in nature; Return lung, gallbladder, spleen, large intestine, small intestine meridian; Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.
19, Caulis Akebiae: be the woody stems of plants of Lardizabalaceae Caulis Akebiae or threeleaf akebia, Caulis Akebiae.Bitter in the mouth, cool in nature; Enter the heart, small intestinal, urinary bladder channel; Pathogenic fire purging row water, promoting blood circulation.
20, Arisaema Cum Bile: this product is that the fine powder of Rhizoma Arisaematis (processed) and cattle, sheep or Fel Sus domestica process from strand, or forms through fermentation processing for Arisaema Cum Bile fine powder and cattle, sheep or Fel Sus domestica.Bitter in the mouth, micro-pungent, cool in nature; Return lung, liver, spleen channel; Removing heat-phlegm, dispelling wind and relieving convulsion.
21, Radix Glycyrrhizae Preparata: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The side of Chinese prescription of the present invention separates:
This Chinese prescription is with Fructus Trichosanthis, Magnetitum, fresh Radix Phytolaccae, Radix Pseudostellariae, Radix Et Rhizoma Rhei, Radix Scutellariae for monarch drug, clearing away heat and eliminating phlegm, tranquillizing the mind by relieving convulsion, detoxicating and resolving stagnation of pathogens, replenishing QI to invigorate the spleen, eliminating blood stasis and inducing menstruation, eliminating fire and detoxication; With Radix Curcumae, Concha Ostreae, Radix Gentianae, Poria cum Radix Pini, Caulis Akebiae for ministerial drug, heart fire-clearing upset-relieving, tranquillization with heavy prescription, eliminating pathogen in the liver gallbladder fire, mind tranquilizing and the heart calming, promoting blood circulation; With the Radix Paeoniae Alba, Cortex Albiziae, Semen Persicae, Arisaema Cum Bile, Exocarpium Citri Rubrum for adjuvant drug, nourishing blood for regulating menstruation, resolving stagnation for tranquilization, blood circulation promoting and blood stasis dispelling, dispelling wind and relieving convulsion, promoting the circulation of QI expectorant; With Rhizoma Coptidis, Rhizoma Acori Graminei, Radix Polygalae, Natrii Sulfas for making medicine, eliminating fire and detoxication, eliminating phlegm of having one's ideas straightened out, Fructus Alpiniae Oxyphyllae of calming the nerves, relieving inflammation or internal heat and purging heat; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, the all medicines of monarch are taken mutually, negative and positive are harmonious, assist each other, jointly reach clearing away heat and eliminating phlegm, tranquillizing the mind by relieving convulsion, detoxicating and resolving stagnation of pathogens, heart fire-clearing upset-relieving, blood circulation promoting and blood stasis dispelling, dispelling wind and relieving convulsion, promoting the circulation of QI expectorant, eliminating phlegm of having one's ideas straightened out, Fructus Alpiniae Oxyphyllae of calming the nerves, effect such as to purge heat of relieving inflammation or internal heat, to schizophrenia, there is very significant curative effect.
Compared with prior art, the present invention's technical advantage significantly such as Chinese medicine preparation has good effect in treatment schizophrenia, drug effect is gentle, medical treatment combines, have no side effect of preparing that the method for the treatment of schizoid Chinese medicine preparation produces; In addition, its preparation process advanced person, preparation efficacy stability, the feature such as to be applicable to applying also be its obvious technical advantage.
Detailed description of the invention
Embodiment 1
The practice carrying out pill by the preferred process parameter of the boundary value in Chinese prescription medical material weight range of the present invention and preparation method is produced:
(1) Fructus Trichosanthis 1200g, Radix Pseudostellariae 1000g, Magnetitum 1200g, Rhizoma Coptidis 700g, Rhizoma Acori Graminei 600g, Radix Curcumae 700g, Concha Ostreae 700g, Radix Polygalae 500g, fresh Radix Phytolaccae 1500g, Radix Paeoniae Alba 900g, Poria cum Radix Pini 700g, Radix Et Rhizoma Rhei 1700g, Exocarpium Citri Rubrum 600g, Radix Gentianae 800g, Semen Persicae 700g, Natrii Sulfas 400g, Cortex Albiziae 700g, Radix Scutellariae 1000g, Caulis Akebiae 700g, Arisaema Cum Bile 400g, Radix Glycyrrhizae Preparata 600g is taken respectively by Chinese prescription of the present invention;
(2) Radix Glycyrrhizae Preparata is pulverized, levigate, cross 100 mesh sieves, obtain fine powder a, for subsequent use;
(3) fresh Radix Phytolaccae pulverizing is squeezed the juice, filter to obtain Radix Phytolaccae juice, for subsequent use;
(4) Fructus Trichosanthis, Magnetitum, Rhizoma Coptidis, Concha Ostreae, Radix Polygalae, the Radix Paeoniae Alba, Poria cum Radix Pini, Radix Et Rhizoma Rhei, Exocarpium Citri Rubrum, Radix Gentianae, Natrii Sulfas, Cortex Albiziae, Radix Scutellariae are pulverized and mixed respectively, add the purified water of initial medical material 12 times of weight, soak 10 hours, backflow decoction 3 hours, filters, then adds the purified water of initial weight 9 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.20-1.23 is for subsequent use;
(5) filtering residue of Radix Pseudostellariae, Rhizoma Acori Graminei, Radix Curcumae, Semen Persicae, Caulis Akebiae, Arisaema Cum Bile and step (4) is added the ethanol of the concentration 75% of 10 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.20-1.23 is for subsequent use;
(6) merged by the concentrated solution of step (3) gained Radix Phytolaccae juice and step (4) and (5) gained, continuing to be concentrated into 50 DEG C of relative densities is the Chinese medical concrete of 1.36-1.39, and vacuum drying, to dry extract, is pulverized levigate, crosses 100 mesh sieves, obtains fine powder b, for subsequent use;
(7) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make pill, specification is: 0.88g crude drug/g pill.
Embodiment 2
The practice carrying out pill by the preferred process parameter of the boundary value in Chinese prescription medical material weight range of the present invention and preparation method is produced:
(1) Fructus Trichosanthis 3600g, Radix Pseudostellariae 3000g, Magnetitum 3400g, Rhizoma Coptidis 1900g, Rhizoma Acori Graminei 1700g, Radix Curcumae 2700g, Concha Ostreae 2900g, Radix Polygalae 1600g, fresh Radix Phytolaccae 5300g, Radix Paeoniae Alba 2500g, Poria cum Radix Pini 2900g, Radix Et Rhizoma Rhei 4000g, Exocarpium Citri Rubrum 1900g, Radix Gentianae 2800g, Semen Persicae 2200g, Natrii Sulfas 1100g, Cortex Albiziae 2300g, Radix Scutellariae 3200g, Caulis Akebiae 2500g, Arisaema Cum Bile 1200g, Radix Glycyrrhizae Preparata 1500g is taken respectively by Chinese prescription of the present invention;
(2) Radix Glycyrrhizae Preparata is pulverized, levigate, cross 100 mesh sieves, obtain fine powder a, for subsequent use;
(3) fresh Radix Phytolaccae pulverizing is squeezed the juice, filter to obtain Radix Phytolaccae juice, for subsequent use;
(4) Fructus Trichosanthis, Magnetitum, Rhizoma Coptidis, Concha Ostreae, Radix Polygalae, the Radix Paeoniae Alba, Poria cum Radix Pini, Radix Et Rhizoma Rhei, Exocarpium Citri Rubrum, Radix Gentianae, Natrii Sulfas, Cortex Albiziae, Radix Scutellariae are pulverized and mixed respectively, add the purified water of initial medical material 12 times of weight, soak 10 hours, backflow decoction 3 hours, filters, then adds the purified water of initial weight 9 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.20-1.23 is for subsequent use;
(5) filtering residue of Radix Pseudostellariae, Rhizoma Acori Graminei, Radix Curcumae, Semen Persicae, Caulis Akebiae, Arisaema Cum Bile and step (4) is added the ethanol of the concentration 75% of 10 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.20-1.23 is for subsequent use;
(6) merged by the concentrated solution of step (3) gained Radix Phytolaccae juice and step (4) and (5) gained, continuing to be concentrated into 50 DEG C of relative densities is the Chinese medical concrete of 1.36-1.39, and vacuum drying, to dry extract, is pulverized levigate, crosses 100 mesh sieves, obtains fine powder b, for subsequent use;
(7) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make pill, specification is: 0.88g crude drug/g pill.
Embodiment 3
The practice carrying out pill by the preferred process parameter of the arbitrary value in Chinese prescription medical material weight range of the present invention and preparation method is produced:
(1) Fructus Trichosanthis 3600g, Radix Pseudostellariae 1000g, Magnetitum 3400g, Rhizoma Coptidis 700g, Rhizoma Acori Graminei 1700g, Radix Curcumae 700g, Concha Ostreae 2900g, Radix Polygalae 1600g, fresh Radix Phytolaccae 1500g, Radix Paeoniae Alba 2500g, Poria cum Radix Pini 700g, Radix Et Rhizoma Rhei 4000g, Exocarpium Citri Rubrum 600g, Radix Gentianae 2800g, Semen Persicae 2200g, Natrii Sulfas 400g, Cortex Albiziae 2300g, Radix Scutellariae 1000g, Caulis Akebiae 2500g, Arisaema Cum Bile 400g, Radix Glycyrrhizae Preparata 1500g is taken respectively by Chinese prescription of the present invention;
(2) Radix Glycyrrhizae Preparata is pulverized, levigate, cross 100 mesh sieves, obtain fine powder a, for subsequent use;
(3) fresh Radix Phytolaccae pulverizing is squeezed the juice, filter to obtain Radix Phytolaccae juice, for subsequent use;
(4) Fructus Trichosanthis, Magnetitum, Rhizoma Coptidis, Concha Ostreae, Radix Polygalae, the Radix Paeoniae Alba, Poria cum Radix Pini, Radix Et Rhizoma Rhei, Exocarpium Citri Rubrum, Radix Gentianae, Natrii Sulfas, Cortex Albiziae, Radix Scutellariae are pulverized and mixed respectively, add the purified water of initial medical material 12 times of weight, soak 10 hours, backflow decoction 3 hours, filters, then adds the purified water of initial weight 9 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.20-1.23 is for subsequent use;
(5) filtering residue of Radix Pseudostellariae, Rhizoma Acori Graminei, Radix Curcumae, Semen Persicae, Caulis Akebiae, Arisaema Cum Bile and step (4) is added the ethanol of the concentration 75% of 10 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.20-1.23 is for subsequent use;
(6) merged by the concentrated solution of step (3) gained Radix Phytolaccae juice and step (4) and (5) gained, continuing to be concentrated into 50 DEG C of relative densities is the Chinese medical concrete of 1.36-1.39, and vacuum drying, to dry extract, is pulverized levigate, crosses 100 mesh sieves, obtains fine powder b, for subsequent use;
(7) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make pill, specification is: 0.88g crude drug/g pill.
Embodiment 4
The practice carrying out pill by the medical material proportioning of the preferred Chinese prescription of the present invention and the preferred process parameter of preparation method is produced:
(1) Fructus Trichosanthis 2400g, Radix Pseudostellariae 2000g, Magnetitum 2200g, Rhizoma Coptidis 1300g, Rhizoma Acori Graminei 1100g, Radix Curcumae 1700g, Concha Ostreae 1800g, Radix Polygalae 1000g, fresh Radix Phytolaccae 3400g, Radix Paeoniae Alba 1500g, Poria cum Radix Pini 1700g, Radix Et Rhizoma Rhei 2700g, Exocarpium Citri Rubrum 1300g, Radix Gentianae 1900g, Semen Persicae 1400g, Natrii Sulfas 700g, Cortex Albiziae 1400g, Radix Scutellariae 2100g, Caulis Akebiae 1700g, Arisaema Cum Bile 800g, Radix Glycyrrhizae Preparata 1200g is taken respectively by Chinese prescription of the present invention;
(2) Radix Glycyrrhizae Preparata is pulverized, levigate, cross 100 mesh sieves, obtain fine powder a, for subsequent use;
(3) fresh Radix Phytolaccae pulverizing is squeezed the juice, filter to obtain Radix Phytolaccae juice, for subsequent use;
(4) by Fructus Trichosanthis, Magnetitum, Rhizoma Coptidis, Concha Ostreae, Radix Polygalae, the Radix Paeoniae Alba, Poria cum Radix Pini, Radix Et Rhizoma Rhei, Exocarpium Citri Rubrum, Radix Gentianae, Natrii Sulfas, Cortex Albiziae, Radix Scutellariae, be pulverized and mixed respectively, add the purified water of initial medical material 12 times of weight, soak 10 hours, backflow decoction 3 hours, filters, then adds the purified water of initial weight 9 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.20-1.23 is for subsequent use;
(5) filtering residue of Radix Pseudostellariae, Rhizoma Acori Graminei, Radix Curcumae, Semen Persicae, Caulis Akebiae, Arisaema Cum Bile and step (4) is added the ethanol of the concentration 75% of 10 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.20-1.23 is for subsequent use;
(6) merged by the concentrated solution of step (3) gained Radix Phytolaccae juice and step (4) and (5) gained, continuing to be concentrated into 50 DEG C of relative densities is the Chinese medical concrete of 1.36-1.39, and vacuum drying, to dry extract, is pulverized levigate, crosses 100 mesh sieves, obtains fine powder b, for subsequent use;
(7) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make pill, specification is: 0.88g crude drug/g pill.
Embodiment 5
The practice carrying out pill by the medical material proportioning of the preferred Chinese prescription of the present invention and the preferred process parameter of preparation method is produced:
(1) Fructus Trichosanthis 2600g, Radix Pseudostellariae 2200g, Magnetitum 2000g, Rhizoma Coptidis 1400g, Rhizoma Acori Graminei 1000g, Radix Curcumae 1900g, Concha Ostreae 1700g, Radix Polygalae 1000g, fresh Radix Phytolaccae 3800g, Radix Paeoniae Alba 1400g, Poria cum Radix Pini 1800g, Radix Et Rhizoma Rhei 2600g, Exocarpium Citri Rubrum 1100g, Radix Gentianae 1700g, Semen Persicae 1300g, Natrii Sulfas 700g, Cortex Albiziae 1700g, Radix Scutellariae 2300g, Caulis Akebiae 1800g, Arisaema Cum Bile 900g, Radix Glycyrrhizae Preparata 1300g is taken respectively by Chinese prescription of the present invention;
(2) Radix Glycyrrhizae Preparata is pulverized, levigate, cross 100 mesh sieves, obtain fine powder a, for subsequent use;
(3) fresh Radix Phytolaccae pulverizing is squeezed the juice, filter to obtain Radix Phytolaccae juice, for subsequent use;
(4) Fructus Trichosanthis, Magnetitum, Rhizoma Coptidis, Concha Ostreae, Radix Polygalae, the Radix Paeoniae Alba, Poria cum Radix Pini, Radix Et Rhizoma Rhei, Exocarpium Citri Rubrum, Radix Gentianae, Natrii Sulfas, Cortex Albiziae, Radix Scutellariae are pulverized and mixed respectively, add the purified water of initial medical material 12 times of weight, soak 10 hours, backflow decoction 3 hours, filters, then adds the purified water of initial weight 9 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.20-1.23 is for subsequent use;
(5) filtering residue of Radix Pseudostellariae, Rhizoma Acori Graminei, Radix Curcumae, Semen Persicae, Caulis Akebiae, Arisaema Cum Bile and step (4) is added the ethanol of the concentration 75% of 10 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.20-1.23 is for subsequent use;
(6) merged by the concentrated solution of step (3) gained Radix Phytolaccae juice and step (4) and (5) gained, continuing to be concentrated into 50 DEG C of relative densities is the Chinese medical concrete of 1.36-1.39, and vacuum drying, to dry extract, is pulverized levigate, crosses 100 mesh sieves, obtains fine powder b, for subsequent use;
(7) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make pill, specification is: 0.88g crude drug/g pill.
Test example 1: the animal toxicity test of Chinese medicine preparation of the present invention
1, acute toxicity test
(1) test medicine: the pill manufactured by embodiment of the present invention 1-5, adds purified water, is modulated into the magma of desired concn, for subsequent use.
(2) experimental animal: common Kunming mouse, body weight 25g ± 4g, male and female half and half, female mice is all without pregnant.Herd laboratory animal plant from upper Hypon to buy.
(3) magma of mouse stomach medicine pill preparation of the present invention, when given low reaches 597.2g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal.
(4) result of the test shows: the maximum dosage-feeding of the pill manufactured by mouse stomach embodiment 1-5 is 597.2g crude drug/kg/d(LD
50> 597.2g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.44g crude drug/kg/d; By weighing machine, the dosis tolerata of the pill manufactured by mouse stomach embodiment 1-5 is 1357.3 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
2, long-term toxicity test for animals
(1) test medicine: embodiment of the present invention 1-5 gained medicine pill, adds purified water, is modulated into the magma of desired concn, for subsequent use.
(2) experimental animal: regular grade SD rat, body weight 232g ± 15g, male and female half and half, female rats is all without pregnant.Herd laboratory animal plant from upper Hypon to buy.
(3) method and result:
5 kinds of medicine pills: be divided into high, medium and low three dosage groups, per weight dosage is respectively 180,60,20 times of patient's dose; Experimental mouse is divided into 16 groups at random, and wherein the pill solution of 15 groups of difference gavages, 5 kinds of three dosage, remains 1 group of gavage equal-volume normal saline (20 times of patient's dose); All 16 groups of all continuous gavages 180 days, observe animal general toxic reaction and the order of severity, check each position, and carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach after execution by rule of operation;
Through long-term feeding, all there is not toxic reaction in 16 group rats.Physically well develop.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN compare with matched group and change without pathologic.The all not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, therefore, think through proved by pathology, 5 kinds of medicine pills show without chronic toxicity animal.
By above two toxicity tests, prove that the present invention is safe by the medicine pill that embodiment 1-5 makes, have no side effect, can be taken by patient.
Test example 2: the pharmacodynamic experiment of Chinese medicine preparation of the present invention
1, spontaneous activity in mice test
Get KM mice 80, male and female half and half.By sex, body weight is divided into matched group at random, the positive group (Aripiprazole sheet) of Western medicine and the embodiment of the present invention 4, the pill (specification is: 0.88g crude drug/g pill) that embodiment 5 is produced is high, in, low dose group (17.6g crude drug/kg, 8.8g crude drug/kg and 4.4g crude drug/kg, be respectively 40 of clinical consumption per day, 20, 10 times), totally 8 groups, continuous gastric infusion 5 days, spontaneous activity (stand number of times and the walk about number of times) situation of mice after observing the 1st gastric infusion and after last gastric infusion, statistical analysis between organizing, evaluate test sample sedation, the results are shown in Table 1 and table 2.
The test of table 1 Chinese medicine preparation single-dose of the present invention spontaneous activity in mice (
± SD, n=10)
Note: each administration group compares with model control group
*p < 0.05,
*p < 0.01,
* *p < 0.001.
The test of table 2 Chinese medicine preparation multiple dosing of the present invention spontaneous activity in mice (
± SD, n=10)
Note: each administration group compares with model control group
*p < 0.05,
*p < 0.01,
* *p < 0.001.
Experimental result shows, Chinese medicine preparation single-dose of the present invention and multiple dosing (successive administration 5 days) afterwards 1h significantly can reduce mice and to stand number of times and to walk about number of times (P < 0.01 or P < 0.001), sedation is dose-effect relationship, Chinese medicine preparation multiple dosing is suitable with single-dose sedation effect, illustrates and does not produce Drug tolerance; Further, the sedation effect of its high dose group is suitable with Aripiprazole sheet.
Conclusion: Chinese medicine preparation of the present invention has good sedation.
2, mice pentobarbital sodium threshold dose and sub-threshold dose hypnosis test
If pill (specification is: 0.88g crude drug/g pill) high, medium and low dosage group (17.6g crude drug/kg, 8.8g crude drug/kg and 4.4g crude drug/kg that the positive group (Aripiprazole sheet) of matched group, Western medicine and the embodiment of the present invention 4, embodiment 5 are produced, be respectively 40,20,10 times of clinical consumption per day), often organize 20 KM kind mices, male and female half and half.Continuous gastric infusion 5 days, after observing the 1st gastric infusion and after last gastric infusion, on the impact of pentobarbital sodium threshold dose syngignoscism (hypnosis incubation period and hypnosis time), and the impact on pentobarbital sodium sub-threshold dose inducing mouse sleep quantity, evaluate its sedation, statistical analysis between organizing, evaluates test sample sedation, the results are shown in Table 3 and table 4.
Table 3 Chinese medicine preparation single-dose of the present invention mice pentobarbital sodium sub-threshold dose hypnosis test
Note: each administration group compares with model control group
*p < 0.05,
*p < 0.01,
* *p < 0.001.
Table 4 Chinese medicine preparation multiple dosing of the present invention mice pentobarbital sodium sub-threshold dose hypnosis test
Note: each administration group compares with model control group
*p < 0.05,
*p < 0.01,
* *p < 0.001.
Experimental result shows, after Chinese medicine preparation single-dose of the present invention and multiple dosing (successive administration 5 days), there is prolongation threshold dose and sub-threshold dose pentobarbital sodium syngignoscism, the syngignoscism effect of its high dose group is suitable with Aripiprazole sheet, and use not easily produces drug resistance continuously, this point is better than Aripiprazole sheet.
Conclusion: Chinese medicine preparation of the present invention has good sedation.
Test example 3: the clinical trial of Chinese medicine preparation of the present invention
The patient of this clinical trial, all from the People's Hospital of certain city the 3rd, from the patient that this institute accepts for medical treatment year June in June, 2012 to 2015, filters out patient 156 people participating in this test voluntarily, age 22-64 year, man 60 people, female 96 people, all experimenters have been made a definite diagnosis all suffers from schizophrenia.All patients are equally divided into two groups, often organize male 30 people, female 48 people, two groups of patients are the pill (specification is: 0.88g crude drug/g pill) produced of the oral embodiment of the present invention 4, embodiment 5 respectively, every day 3 times, each 10g, within 2 weeks, be a course for the treatment of, treat 4 courses for the treatment of continuously.Wherein often organized 2 examples to come off because of patient compliance's sex chromosome mosaicism, all the other patients complete test, and therapeutic outcome statistics is as table 5.
Table 5 clinical trial therapeutic outcome
Result of the test confirms further, Chinese medicine preparation of the present invention has very significant curative effect to schizophrenia, the total effective rate of embodiment 4 groups and embodiment 5 groups is respectively up to 94.7% and 96.1%, illustrate the present invention prepare treat schizoid Chinese medicine preparation method produce Chinese medicine preparation achieve huge technological progress in schizoid treatment field, obtain beyond thought technological achievement.
Identical verification experimental verification is carried out to other embodiments of the invention, has achieved similar test effect.
Claims (2)
1. prepare a method for the treatment of schizoid Chinese medicine preparation, it is characterized in that comprising the following steps:
(1) raw material of following weight portion is taken: Fructus Trichosanthis 12-36 part, Radix Pseudostellariae 10-30 part, Magnetitum 12-34 part, Rhizoma Coptidis 7-19 part, Rhizoma Acori Graminei 6-17 part, Radix Curcumae 7-27 part, Concha Ostreae 7-29 part, Radix Polygalae 5-16 part, fresh Radix Phytolaccae 15-53 part, Radix Paeoniae Alba 9-25 part, Poria cum Radix Pini 7-29 part, Radix Et Rhizoma Rhei 17-40 part, Exocarpium Citri Rubrum 6-19 part, Radix Gentianae 8-28 part, Semen Persicae 7-22 part, Natrii Sulfas 4-11 part, Cortex Albiziae 7-23 part, Radix Scutellariae 10-32 part, Caulis Akebiae 7-25 part, Arisaema Cum Bile 4-12 part, Radix Glycyrrhizae Preparata 6-15 part;
(2) Radix Glycyrrhizae Preparata is pulverized, levigate, cross 80-130 mesh sieve, obtain fine powder a, for subsequent use;
(3) fresh Radix Phytolaccae pulverizing is squeezed the juice, filter to obtain Radix Phytolaccae juice, for subsequent use;
(4) Fructus Trichosanthis, Magnetitum, Rhizoma Coptidis, Concha Ostreae, Radix Polygalae, the Radix Paeoniae Alba, Poria cum Radix Pini, Radix Et Rhizoma Rhei, Exocarpium Citri Rubrum, Radix Gentianae, Natrii Sulfas, Cortex Albiziae, Radix Scutellariae are pulverized and mixed respectively, add the purified water of initial medical material 6-16 times weight, soak 4-24 hour, backflow decocts 1-5 hour, filters, then adds the purified water of initial weight 4-12 times weight, backflow decocts 1-4 hour, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.20-1.23 is for subsequent use;
(5) filtering residue of Radix Pseudostellariae, Rhizoma Acori Graminei, Radix Curcumae, Semen Persicae, Caulis Akebiae, Arisaema Cum Bile and step (4) is added the ethanol of the concentration 65-85% of 5-12 times of weight, reflux, extract, 2 times, each 1-5 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.20-1.23 is for subsequent use;
(6) merged by the concentrated solution of step (3) gained Radix Phytolaccae juice and step (4) and (5) gained, continuing to be concentrated into 50 DEG C of relative densities is the Chinese medical concrete of 1.36-1.39, and vacuum drying is to dry extract, pulverize levigate, cross 80-130 mesh sieve, obtain fine powder b, for subsequent use;
(7) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make the Chinese medicine finished product preparation of clinical needs.
2. according to claim 1ly prepare the method for the treatment of schizoid Chinese medicine preparation, it is characterized in that: the dosage form of described Chinese medicine preparation is decoction, pill, powder, unguentum, sublimed preparation, medicated wine, syrup, extractum, lozenge, distillate medicinal water, colloid, medicinal tea, nail agent, stick, suppository, herbal leaven, paste, cake agent, wash liniment, oil preparation, line agent, medicated roll, press agent, process agent, fumicants, tablet, tincture, capsule or granule.
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| CN106943574A (en) * | 2017-05-01 | 2017-07-14 | 徐士魁 | One kind treats schizoid medicine and preparation method thereof |
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| CN101940679A (en) * | 2010-03-31 | 2011-01-12 | 许高峰 | Traditional Chinese medicine composition capable of soothing mood and collecting mind |
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| CN101940679A (en) * | 2010-03-31 | 2011-01-12 | 许高峰 | Traditional Chinese medicine composition capable of soothing mood and collecting mind |
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| CN105853755A (en) * | 2016-05-24 | 2016-08-17 | 包晓娜 | Traditional Chinese medicine composition for treating schizophrenia |
| CN106943574A (en) * | 2017-05-01 | 2017-07-14 | 徐士魁 | One kind treats schizoid medicine and preparation method thereof |
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