CN105288173A - Traditional Chinese medicine pellet preparation for regulating menstruation and removing freckles and preparation method thereof - Google Patents
Traditional Chinese medicine pellet preparation for regulating menstruation and removing freckles and preparation method thereof Download PDFInfo
- Publication number
- CN105288173A CN105288173A CN201410309888.7A CN201410309888A CN105288173A CN 105288173 A CN105288173 A CN 105288173A CN 201410309888 A CN201410309888 A CN 201410309888A CN 105288173 A CN105288173 A CN 105288173A
- Authority
- CN
- China
- Prior art keywords
- radix
- preparation
- powder
- effective ingredient
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 71
- 238000002360 preparation method Methods 0.000 title claims abstract description 42
- 239000008188 pellet Substances 0.000 title claims abstract description 28
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 5
- 230000005906 menstruation Effects 0.000 title abstract description 8
- 230000001105 regulatory effect Effects 0.000 title abstract description 5
- 206010014970 Ephelides Diseases 0.000 title abstract 2
- 239000000843 powder Substances 0.000 claims abstract description 66
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 44
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 35
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 35
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 35
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 35
- 229940079593 drug Drugs 0.000 claims abstract description 33
- 239000000284 extract Substances 0.000 claims abstract description 12
- 239000008280 blood Substances 0.000 claims description 30
- 210000004369 blood Anatomy 0.000 claims description 30
- 239000004615 ingredient Substances 0.000 claims description 30
- 210000000582 semen Anatomy 0.000 claims description 28
- 239000006071 cream Substances 0.000 claims description 25
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 15
- 241000628997 Flos Species 0.000 claims description 14
- 239000009636 Huang Qi Substances 0.000 claims description 14
- 108010052008 colla corii asini Proteins 0.000 claims description 14
- 239000012153 distilled water Substances 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 11
- 239000007779 soft material Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 5
- 208000007106 menorrhagia Diseases 0.000 claims description 4
- 206010008570 Chloasma Diseases 0.000 claims description 3
- 206010013786 Dry skin Diseases 0.000 claims description 3
- 238000005563 spheronization Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 claims description 2
- 238000005453 pelletization Methods 0.000 claims 2
- 230000036772 blood pressure Effects 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 238000010334 sieve classification Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 238000005516 engineering process Methods 0.000 abstract description 6
- 239000002552 dosage form Substances 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 2
- 238000012216 screening Methods 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 9
- 238000000605 extraction Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000006187 pill Substances 0.000 description 6
- 239000002021 butanolic extract Substances 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 235000013312 flour Nutrition 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 208000019255 Menstrual disease Diseases 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 239000012567 medical material Substances 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 229930003944 flavone Natural products 0.000 description 2
- 150000002212 flavone derivatives Chemical class 0.000 description 2
- 235000011949 flavones Nutrition 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 2
- XUCIJNAGGSZNQT-JHSLDZJXSA-N (R)-amygdalin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H](C#N)C=2C=CC=CC=2)O1 XUCIJNAGGSZNQT-JHSLDZJXSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 description 1
- ATWHGWYKSFRYBN-UHFFFAOYSA-N Amygdaloside Natural products O1C(=O)C2(C)CCCC(C3CC4)(C)C2C1OCC3(C1)CC4C1(O)COC1OC(CO)C(O)C(O)C1O ATWHGWYKSFRYBN-UHFFFAOYSA-N 0.000 description 1
- 208000037259 Amyloid Plaque Diseases 0.000 description 1
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- ZUKLFFYDSALIQW-MSUKCBDUSA-N Iridoid glycoside Chemical compound [H][C@]12CC[C@H](C(O)=O)[C@@]1([H])[C@H](OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)OC=C2 ZUKLFFYDSALIQW-MSUKCBDUSA-N 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- -1 coumarin, terpenoid compound Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 229930182489 iridoid glycoside Natural products 0.000 description 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine pellet preparation for regulating menstruation and removing freckles and a preparation method thereof and belongs to preparation technology of Chinese patent medicine. The traditional Chinese medicine pellet preparation is characterized in that the pellet preparation is a pellet composed of dry extract powder of active ingredient water extract, crude drug powder and microcrystalline cellulose, grain size of the pellet is smaller than 2.5mm, and a weight ratio of the dry extract powder and the crude drug powder to microcrystalline cellulose is 1 to (0.5-1.0). The inventor performs studying on production process, screening of excipient type and solvent amount proportion experimenting, so that the traditional Chinese medicine pellet preparation has the advantages of high medicine releasing speed, high bioavailability, little irritancy, accurate divided dose and convenience for administration and carrying. Through dosage form updating, high cost and safety risk of existing production processes are improved, requirements of enterprises on convenience and safety of production process are met, and a novel medicine preparation which is more convenient to take and cheaper in price is provided for patients.
Description
Technical field
The invention belongs to the preparation technique field of Chinese patent medicine, particularly relate to a kind of Chinese medicine pellet preparation and preparation method of menstruation-regulating and speckle-dispelling.
Background technology
According to pathogenesis and the rule for the treatment of of Chinese medical discrimination, the composition mainly blood of menstruation.So, QI and blood be mutually grow with project interdependent, qi being the governor of blood, blood being the material foundation of QI, disorders of blood can and gas, disorder of QI can and blood, have extremely close relationship each other.So QI and blood is the basic substance of menstruation, not having QI and blood also would not have menorrhea, then must there is menoxenia in disorder of QI and blood.QI and blood be internal organs biochemical, kidney controlling essence storage among internal organs, poly-congenital essence and hide it; The spleen being the foundation of acquired constitution, source of generating QI and blood, can often abide by follow by hemopoietic again.So, essence can be biochemical, and blood also can change into essence, essence and blood sharing the same origin, mutually grow, and with the internal organs such as the heart, liver, spleen, stomach between make mutually and assist mutually, complement each other, function just can be made normal, QI and blood is vigorous, and it is strong to rush wantonly two arteries and veins functions, uterus " Tibetan is rushed down joint ", " store the degree of having that overflows ", menstruation also can be painless.If function is not normal, biochemical not enough, QI and blood is lost then punching times and is lost in nourishing, two arteries and veins functional disorders, the sea of blood can not completely be full of or blood stasis, phlegm-damp, the stagnation of QI on time, so that functional activity of QI being not smooth, as weak in liver temper, QI failing to control blood or heat chase after the absurd row of blood then can cause preceeded menorrhea, menorrhagia, menostaxis etc.; Gas, anemia are damaged, and deficiency of kidney-YIN, can not Rong Yan.Therefore menoxenia can derive mottle and dysmenorrhea etc.Modern medicine is then thought, menoxenia is mainly not normal relevant with endocrine dysfunction, hormone metabolism.
With the Chinese medicine that the Radix Astragali, Radix Rehmanniae Preparata, Herba Ecliptae, the Radix Paeoniae Alba, Radix Rehmanniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Lycii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Rhizoma Gymnadeniae, Semen Persicae, Radix Bupleuri, Colla Corii Asini, Flos Carthami are made, there is nourishing blood for regulating menstruation, effect of dissolving stasis and dispelling spots, can be used for nutrient QI and blood being insufficient, qi depression to blood stasis, menorrhagia, chloasma etc.Concrete weight portion prescription is as follows:: Radix Astragali 35-45, Radix Rehmanniae Preparata 25-35, Herba Ecliptae 20-30, Radix Paeoniae Alba 20-30, Radix Rehmanniae 20-30, Semen Cuscutae 15-25, Fructus Ligustri Lucidi 15-25, Fructus Lycii 15-25, Radix Angelicae Sinensis 15-25, Radix Polygoni Multiflori 15-25, Rhizoma Gymnadeniae 15-25, Semen Persicae 10-20, Radix Bupleuri 10-20, Colla Corii Asini 4-8, Flos Carthami 4-8.With nourishing blood and invigorating qis such as the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Colla Corii Asini, Rhizoma Gymnadeniae, invigorating the spleen for eliminating dampness; The liver and kidney tonifying such as Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Lycii, liver blood kidney essense is sufficient, the face skin care of self energy China, and god's peace gas is felt well; Radix Polygoni Multiflori and Radix Bupleuri share can dispersing the stagnated live-QI to relieve the stagnation of QI; Radix Rehmanniae and Herba Ecliptae share invigorating the liver and kidney clearly, clearing away heat and cooling blood; Semen Persicae and Flos Carthami share blood circulation promoting and blood stasis dispelling.All medicines share plays nourishing blood for regulating menstruation altogether, effect of dissolving stasis and dispelling spots.
This prescription Chinese patent medicine only has 2 kinds of dosage forms such as capsule and tablet on the market at present.Capsule is used by attached Xijing hospital of The Fourth Military Medical University, the routine patient of Tang Dou hospital more than 70,000, and prove that this prescription is the choice drug of menstruation-regulating and speckle-dispelling determined curative effect, total effective rate is: chloasma 94.6%, senile plaque 92%, menoxenia 96.4%, dysmenorrhea 96%, acne 76.5%.
Based on the Clinical Basis that this prescription is good, but due to capsule and tablet, not easily swallow, be easy to the moisture absorption, less stable, not easily preserve; In order to enrich dosage form kind, play the good efficacy of this medicine better, the present inventor studies further, changed into pellet, the curative effect of former preparation can not only be retained preferably, and swallow compared with capsule and tablet more convenient, carry, store also more convenient, and stability improves a lot.By the research of production technology, the screening of supplementary product kind and quantity of solvent Ratio Experiments, this Chinese medicine pellet is had, and drug release rate is fast, bioavailability is high, zest is little, divided dose is accurate, take, the advantage such as easy to carry.By the renewal of dosage form, the high cost improving existing production technology and security risks, meet the facilitation of enterprise's production technology, safe, take more convenient, that price is more cheap new pharmaceutical formulation for patient provides again.Meanwhile, we establish more perfect quality standard, effectively can control the quality of this kind.Through retrieval, said preparation still belongs to internal blank.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine pellet preparation and preparation method of menstruation-regulating and speckle-dispelling, said preparation is by the Radix Astragali, Radix Rehmanniae Preparata, Herba Ecliptae, the Radix Paeoniae Alba, Radix Rehmanniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Lycii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Rhizoma Gymnadeniae, Semen Persicae, Radix Bupleuri, Colla Corii Asini, the Chinese medicine compositions such as Flos Carthami, there is nourishing blood for regulating menstruation, the function of dissolving stasis and dispelling spots, clinical efficacy is remarkable, so because capsule and tablet are swallowed comparatively difficult, be easy to the moisture absorption, less stable, be subject to a definite limitation clinically, in order to enrich dosage form kind, the curative effect of better this medicine of performance, the applicant studies further to it, develop the pellet of this Chinese patent medicine, not only remain the curative effect of this Chinese patent medicine preferably, and take, carry, preserve more convenient, stability also greatly improves.
Technical scheme of the present invention is as follows:
A kind of Chinese medicine pellet preparation of menstruation-regulating and speckle-dispelling, be made up of the effective ingredient of following weight portion: Radix Astragali 35-45, Radix Rehmanniae Preparata 25-35, Herba Ecliptae 20-30, Radix Paeoniae Alba 20-30, Radix Rehmanniae 20-30, Semen Cuscutae 15-25, Fructus Ligustri Lucidi 15-25, Fructus Lycii 15-25, Radix Angelicae Sinensis 15-25, Radix Polygoni Multiflori 15-25, Rhizoma Gymnadeniae 15-25, Semen Persicae 10-20, Radix Bupleuri 10-20, Colla Corii Asini 4-8, Flos Carthami 4-8, this Chinese medicine pellet preparation is by the dried cream powder of described effective ingredient water extract, crude drug powder and microcrystalline Cellulose are less than the micropill of 2.5mm by the particle diameter that following weight ratio forms: (effective ingredient dried cream powder+crude drug powder): microcrystalline Cellulose=1: 0.5-1.0.
This Chinese medicine pellet preparation is preparation like this: get Fructus Ligustri Lucidi, Fructus Lycii, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Bupleuri, Colla Corii Asini, Rhizoma Gymnadeniae and Flos Carthami powder are broken into fine powder, the seven flavor medicine materials such as all the other Semen Cuscutae decoct with water secondary, add 8-12 times of water gaging at every turn, each decoction 2 hours, collecting decoction, filter, filtrate is concentrated into the thick paste that relative density is 1.30 ~ 1.35 (50 DEG C), drying under reduced pressure, pulverize, add above-mentioned crude drug powder and microcrystalline Cellulose, weight ratio (effective ingredient dried cream powder+crude drug powder): microcrystalline Cellulose=1: 0.5-1.0, mixing, with appropriate water pill, by weight (effective ingredient dried cream powder+crude drug powder+microcrystalline Cellulose): distilled water=1: 0.2-0.4, dry, obtain.
Preferred pellet method for making is: get Fructus Ligustri Lucidi, Fructus Lycii, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Bupleuri, Colla Corii Asini, Rhizoma Gymnadeniae and Flos Carthami powder are broken into fine powder, the seven flavor medicine materials such as all the other Semen Cuscutae decoct with water secondary, add 10 times of water gagings at every turn, each decoction 2 hours, collecting decoction, filter, filtrate is concentrated into the thick paste that relative density is 1.30-1.35 (50 DEG C), drying under reduced pressure, pulverize, add above-mentioned crude drug powder and microcrystalline Cellulose, weight ratio (effective ingredient dried cream powder+crude drug powder): microcrystalline Cellulose=1: 0.5, mixing, with appropriate water pill, by weight (effective ingredient dried cream powder+crude drug powder+microcrystalline Cellulose): distilled water=1: 0.3, dry, obtain.
Present inventor has performed series of experiments, to prove present invention process reasonable, stable and controllable for quality, to guarantee the beneficial effect of medicine.
Experimental example 1: extraction process is investigated
1, the investigation of medical material flour extraction
By prescription optimum proportioning parts by weight, get Radix Paeoniae Alba 300g, Fructus Ligustri Lucidi 240g, Fructus Lycii 240g, Radix Angelicae Sinensis 240g, Rhizoma Gymnadeniae 240g, Radix Bupleuri 180g, Colla Corii Asini 72g, Flos Carthami 60g, nominal gets 3 parts, pulverize respectively, cross 100 mesh sieves, carry out flour extraction investigation, the results are shown in Table 1.
Table 1 flour extraction investigation table
| Sample number into spectrum | Medical material amount (g) | Crude drug powder must measure (g) | Flour extraction (%) |
| 1 | 1572 | 1395 | 88.74 |
| 2 | 1572 | 1380 | 87.79 |
| 3 | 1572 | 1380 | 87.79 |
Above data show, the Radix Paeoniae Alba etc. eight herbal medicine is ground into fine powder, and flour extraction is all more than 85%.
2, the seven flavor medicine material amount of water such as the Radix Astragali is investigated
By prescription optimum proportioning parts by weight, get Radix Astragali 16g, Radix Rehmanniae Preparata 12g, Herba Ecliptae 10g, Radix Rehmanniae 10g, Semen Cuscutae 8g, Radix Polygoni Multiflori 8g, Semen Persicae 6g, nominal gets 3 increment product.8,10,12 times amount that add water respectively decoct secondary, each 2 hours, filter, merging filtrate, concentrated, drying under reduced pressure.Consider above medical material, the Radix Astragali is mainly containing saponin component, Semen Cuscutae is mainly containing flavone, coumarin, terpenoid compound, Herba Ecliptae is mainly containing tannin, amaroid, flavone, isoflavone aglycone and alkaloids composition, and Radix Polygoni Multiflori is mainly containing anthraquinone component, and Radix Rehmanniae is mainly containing iridoid glycoside constituents, Semen Persicae is mainly containing amygdaloside, sterol and steroline constituents, above composition is all dissolved in n-butyl alcohol, therefore with the total amount of n-butanol extract for index, carries out preferably amount of water.Measure n-butanol extract content in 3 extracts by the following method: take extract dried cream powder respectively and be about 3g, accurately weighed, put in the conical flask of 100ml, add the methanol 50ml that precision measures, close plug, weighed weight, left standstill after 1 hour, in water-bath, backflow is heated to boiling, and keeps micro-and boil 1 hour.After letting cool, take off conical flask, close plug, weighed weight, supply the weight of less loss with methanol, shake up, filter with dry filter.Precision measures subsequent filtrate 25ml, evaporate to dryness, residue 30ml water dissolution, with water saturated n-butanol extraction 4 times (30ml, 30ml, 20ml, 20m1), merge extractive liquid, put evaporate to dryness in the evaporating dish of dry weight, residue was in 105 DEG C of dryings 3 hours, in dislocation exsiccator, cool 30 minutes, rapid accurately weighed weight.Calculate the radiotherapy of n-butanol extract in test sample with drying bottle, the results are shown in Table 2.
Table 2 amount of water investigates result table
| Sample number into spectrum | Amount of water | Paste volume (g) | N-butanol extract amount (g/ part) |
| 1 | 8 times amount | 23.5 | 1.12 |
| 2 | 10 times amount | 25.7 | 1.16 |
| 3 | 12 times amount | 27.4 | 1.14 |
Table 2 result shows, 8,10, the 12 times amount n-butanol extract amount difference that add water are little, considers, therefore determine that optimum amount of water is 10 times amount from production is actual.
Experimental example 2 preparations shaping technical study
1, the selection of supplementary product kind
Respectively starch, dextrin and microcrystalline Cellulose are carried out preferably.To get it filled powder (comprising extract dried cream powder and crude drug powder) 150g by best prescription parts by weight, be divided into 3 parts, add appropriate amount of starch, dextrin and microcrystalline Cellulose respectively, add appropriate distilled water after mixing and prepare micropill respectively, the results are shown in Table 3.
The selection result table of table 3 supplementary product kind
Table 3 result shows, and microcrystalline Cellulose as the easier pill of adjuvant, therefore is determined with the excipient of microcrystalline Cellulose as micropill.
2, the selection of microcrystalline Cellulose consumption
To get it filled thing (comprising extract dried cream powder and crude drug powder) 300g by best prescription amount parts by weight, be divided into 3 parts, add appropriate microcrystalline Cellulose and distilled water pill, dry, using the moisture absorption of pill complexity and micropill as inspection target, the results are shown in Table 4.
Table 4 microcrystalline Cellulose consumption is preferably shown
Table 4 result shows, and adds microcrystalline Cellulose 0.5 times, namely can be made into molding good, the not easily micropill of the moisture absorption, therefore selects the microcrystalline Cellulose adding medicated powder 0.5-1.0 times amount.
3, the consumption of wetting agent is selected
This product selects distilled water cheap and easy to get to make wetting agent.Fixing micropill prescription medicated powder: adjuvant is 1: 0.5, and the water adding different proportion makes soft material, pill (hole diameter of sieve (perforated) plate is 1.0mm, and extruded velocity is 30rpm, round as a ball speed 50Hz, and the round as a ball time is 2min).Measure yield and the roundness of micropill, the results are shown in Table 5.
The calculating of yield: sieved by obtained micropill, with 16 ~ 40 order micropills compared with inventory, calculated yield, shows complexity prepared by micropill.
The calculating of roundness: roundness is one of important indicator of micropill, reflects the quality of micropill globulate, directly affects quality and the drug release feature of micropill.The roundness of micropill is evaluated with trait index, namely at random take out 20 micropills that sieve, (17 × 16) measure its maximum diameter and most path under an optical microscope, evaluate the roundness of micropill with the ratio of maximum diameter and most path, the two ratio is less, and roundness is better.
Table 5 wetting agent consumption is on the impact of micropill
| Sample number into spectrum | Distilled water (%) | Yield (%) | Roundness |
| 1 | 20 | 75 | 0.75 |
| 2 | 30 | 81 | 0.86 |
| 3 | 40 | 74 | 0.75 |
Table 5 result shows, and when moisture content is low, extrudate intensity is high, and plasticity is poor, not globulate; During moisture content height, short cylindrical is rolled into spherical rear easily mutual bonding, and yield is reduced.Therefore determine that amount of water is 30%.
4, the selection of hole diameter of sieve (perforated) plate
This product preparations shaping technical study is investigated hole diameter of sieve (perforated) plate, fixing micropill prescription and other process conditions (add 0.5 times amount microcrystalline Cellulose, 30% water soft material, it is 30rpm that agent goes out speed, round as a ball speed 50Hz, the round as a ball time is 2min), prepare micropill with different holes diameter of sieve (perforated) plate, the results are shown in Table 6.
Table 6 hole diameter of sieve (perforated) plate Selection experiment result table
Table 6 result shows, and hole diameter of sieve (perforated) plate does not make significant difference to micropill molding, considers convenient and product appearance of taking medicine in addition, therefore selects hole diameter of sieve (perforated) plate to be that the product of 1.0mm is more satisfactory.
5, the selection of round as a ball speed
Fixing micropill prescription and other process conditions (add 0.5 times amount microcrystalline Cellulose, 30% water soft material, hole diameter of sieve (perforated) plate 1.0mm, it is 30rpm that agent goes out speed, and the round as a ball time is 2min), prepare micropill by different round as a ball speed, the results are shown in Table 7.
Table 7 round as a ball speed Selection experiment result table
| Sample number into spectrum | Round as a ball speed (Hz) | Yield (%) | Roundness |
| 1 | 30 | 76 | 0.75 |
| 2 | 40 | 85 | 0.85 |
| 3 | 50 | 81 | 0.84 |
Table 7 result shows, and during round as a ball speed 40Hz, the roundness of micropill is high, and yield is also better, therefore selects round as a ball speed to be 40Hz.
6, the selection of round as a ball time
Fixing micropill prescription and other process conditions (add 0.5 times amount microcrystalline Cellulose, 30% water soft material, hole diameter of sieve (perforated) plate 1.0mm, it is 30rpm that agent goes out speed, and round as a ball speed is 40Hz), get micropill sample from the different round as a ball time, measure the roundness of micropill, the results are shown in Table 8.
Table 8 round as a ball selection of time result of the test table
| The round as a ball time (min) | Roundness |
| 2 | 0.85 |
| 4 | 0.85 |
| 6 | 0.86 |
| 8 | 0.83 |
| 10 | 0.83 |
Table 8 result shows, and the round as a ball time, the roundness change of micropill was little, therefore selects the round as a ball time to be at least 2min more than after 2min.
Detailed description of the invention
The optimum implementation of this invention is: best effective ingredient composition is by weight: the Radix Astragali 40, Radix Rehmanniae Preparata 30, Herba Ecliptae 25, the Radix Paeoniae Alba 25, Radix Rehmanniae 25, Semen Cuscutae 20, Fructus Ligustri Lucidi 20, Fructus Lycii 20, Radix Angelicae Sinensis 20, Radix Polygoni Multiflori 20, Rhizoma Gymnadeniae 20, Semen Persicae 15, Radix Bupleuri 15, Colla Corii Asini 6, Flos Carthami 5.Get Fructus Ligustri Lucidi, Fructus Lycii, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Bupleuri, Colla Corii Asini, Rhizoma Gymnadeniae and Flos Carthami by the parts by weight of effective ingredient to pulverize, cross 100 mesh sieves and namely obtain crude drug powder.The Radix Astragali, Semen Cuscutae, Herba Ecliptae, Radix Polygoni Multiflori, Radix Rehmanniae, Radix Rehmanniae Preparata and Semen Persicae is got by the parts by weight of effective ingredient, decoct with water secondary, each 2 hours, add 10 times of water gagings, collecting decoction at every turn, filter, filtrate is concentrated into the thick paste that relative density is 1.30 ~ 1.35 (50 DEG C), drying under reduced pressure, pulverizes, cross 100 mesh sieves, obtain effective ingredient dried cream powder.By (effective ingredient dried cream powder+crude drug powder): microcrystalline Cellulose=1: the weight ratio of 0.5, got the microcrystalline Cellulose of 100 mesh sieves, mix with above-mentioned crude drug powder and effective ingredient dried cream powder, by weight (effective ingredient dried cream powder+crude drug powder+microcrystalline Cellulose): distilled water=1: 0.3 adds distilled water obtained mixing soft material, use extrusion-spheronization micropill, hole diameter of sieve (perforated) plate is 1.0mm, extruded velocity is 30rpm, round as a ball speed 40Hz, the round as a ball time be the obtained micropill of 2min. in 60 DEG C of dryings 8 hours, get product micropill.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the technology of the present invention principle; can also make some improvement and modification, these improve and modification also should be considered as protection scope of the present invention.
Claims (7)
1. the Chinese medicine pellet preparation of a menstruation-regulating and speckle-dispelling, be made up of the effective ingredient of following weight portion: Radix Astragali 35-45, Radix Rehmanniae Preparata 25-35, Herba Ecliptae 20-30, Radix Paeoniae Alba 20-30, Radix Rehmanniae 20-30, Semen Cuscutae 15-25, Fructus Ligustri Lucidi 15-25, Fructus Lycii 15-25, Radix Angelicae Sinensis 15-25, Radix Polygoni Multiflori 15-25, Rhizoma Gymnadeniae 15-25, Semen Persicae 10-20, Radix Bupleuri 10-20, Colla Corii Asini 4-8, Flos Carthami 4-8, it is characterized in that: this Chinese medicine pellet preparation is by the dried cream powder of described effective ingredient water extract, crude drug powder and microcrystalline Cellulose are less than the micropill of 2.5mm by the particle diameter that following weight ratio forms: (effective ingredient dried cream powder+crude drug powder): microcrystalline Cellulose=1: 0.5-1.0.
2. the Chinese medicine pellet preparation of a kind of menstruation-regulating and speckle-dispelling according to claim 1, be made up of the effective ingredient of following weight portion: the Radix Astragali 40, Radix Rehmanniae Preparata 30, Herba Ecliptae 25, the Radix Paeoniae Alba 25, Radix Rehmanniae 25, Semen Cuscutae 20, Fructus Ligustri Lucidi 20, Fructus Lycii 20, Radix Angelicae Sinensis 20, Radix Polygoni Multiflori 20, Rhizoma Gymnadeniae 20, Semen Persicae 15, Radix Bupleuri 15, Colla Corii Asini 6, Flos Carthami 5, it is characterized in that: this Chinese medicine pellet preparation is by the dried cream powder of described effective ingredient water extract, crude drug powder and microcrystalline Cellulose are less than the micropill of 2.5mm by the particle diameter that following weight ratio forms: (effective ingredient dried cream powder+crude drug powder): microcrystalline Cellulose=1: 0.5-1.0.
3. the preparation method of the Chinese medicine pellet preparation of menstruation-regulating and speckle-dispelling according to claim 1 and 2, is characterized in that: comprise the steps:
(1) get the Radix Astragali, Semen Cuscutae, Herba Ecliptae, Radix Polygoni Multiflori, Radix Rehmanniae, Radix Rehmanniae Preparata and Semen Persicae by the parts by weight of effective ingredient, decoct with water, filtrate is filtered, and concentrated and blood pressure lowering drying obtains the dried cream powder of effective ingredient water extract;
(2) get Fructus Ligustri Lucidi, Fructus Lycii, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Bupleuri, Colla Corii Asini, Rhizoma Gymnadeniae and Flos Carthami powder by the parts by weight of effective ingredient and be broken into crude drug powder;
(3) the crude drug powder that the dried cream powder obtained by step (1), step (2) obtain and microcrystalline Cellulose sieve respectively, by weight (effective ingredient dried cream powder+crude drug powder): microcrystalline Cellulose=1: 0.5-1.0 mixes, and by weight (effective ingredient dried cream powder+crude drug powder+microcrystalline Cellulose): distilled water=1: 0.2-0.4 adds distilled water obtained mixing soft material, finally extrude, round as a ball, dry, obtain the pellet preparations that particle diameter is less than 2.5mm.
4. the preparation method of the Chinese medicine pellet preparation of menstruation-regulating and speckle-dispelling according to claim 3, is characterized in that: preparation process is as follows:
(1) Radix Astragali, Semen Cuscutae, Herba Ecliptae, Radix Polygoni Multiflori, Radix Rehmanniae, Radix Rehmanniae Preparata and Semen Persicae is got by the parts by weight of effective ingredient, decoct with water 2 times, each 2 hours, each amount of water is the water of 8-12 times of weight, decocting liquid filters and merges, concentrating under reduced pressure, drying under reduced pressure, pulverizes the dried cream powder being worth effective ingredient water extract;
(2) get Fructus Ligustri Lucidi, Fructus Lycii, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Bupleuri, Colla Corii Asini, Rhizoma Gymnadeniae and Flos Carthami powder by the total amount number of effective ingredient and be broken into crude drug powder;
(3) the crude drug powder that the dried cream powder obtained by step (1), step (2) obtain and microcrystalline Cellulose cross 100 mesh sieves respectively, by weight (effective ingredient dried cream powder+crude drug powder): microcrystalline Cellulose=1: 0.5-1.0 mixes, and by weight (effective ingredient dried cream powder+crude drug powder+microcrystalline Cellulose): distilled water=1: 0.2-0.4 adds distilled water obtained mixing soft material;
(4) with extrusion-spheronization pelletizing machine the mixing soft material that step (3) obtains is extruded, round as a ball; obtain the micropill that particle diameter is less than 2.5mm; micropill is as 60 DEG C of dryings in baking oven; finally cross sieve classification; obtain medical treatment nutrient QI and blood being insufficient; qi depression to blood stasis, menorrhagia, the pellet preparations of chloasma Chinese medicine.
5. the preparation method of the Chinese medicine pellet preparation of menstruation-regulating and speckle-dispelling according to claim 4, is characterized in that: the concentrating under reduced pressure described in step (1) is pressure 0.06mpa, concentrated under temperature 60 C condition.
6. the preparation method of the Chinese medicine pellet preparation of menstruation-regulating and speckle-dispelling according to claim 4, is characterized in that: the drying under reduced pressure described in step (1) is pressure-0.1mpa, and temperature is under 80 DEG C of conditions dry 8 hours.
7. the preparation method of the Chinese medicine pellet preparation of menstruation-regulating and speckle-dispelling according to claim 4; it is characterized in that: the granulation conditions of the extrusion-spheronization pelletizing machine described in step (4) is: hole diameter of sieve (perforated) plate is 1.0mm; round as a ball speed is 40Hz, and the round as a ball time is 2min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410309888.7A CN105288173B (en) | 2014-06-30 | 2014-06-30 | A kind of the traditional Chinese medicine pellet preparation and preparation method of menstruation-regulating and speckle-dispelling |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410309888.7A CN105288173B (en) | 2014-06-30 | 2014-06-30 | A kind of the traditional Chinese medicine pellet preparation and preparation method of menstruation-regulating and speckle-dispelling |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105288173A true CN105288173A (en) | 2016-02-03 |
| CN105288173B CN105288173B (en) | 2018-11-23 |
Family
ID=55186451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410309888.7A Active CN105288173B (en) | 2014-06-30 | 2014-06-30 | A kind of the traditional Chinese medicine pellet preparation and preparation method of menstruation-regulating and speckle-dispelling |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105288173B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107050116A (en) * | 2016-11-23 | 2017-08-18 | 广州康臣药物研究有限公司 | It is a kind of to treat medicine pill of diabetic nephropathy and its preparation method and application |
| CN107823155A (en) * | 2017-11-21 | 2018-03-23 | 荆晓玉 | A kind of simple micropill and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985941A (en) * | 2005-12-19 | 2007-06-27 | 珠海天翼医药技术开发有限公司 | Preparing method of micropill of six Chinese medicine materials including glutinous rehmannia |
| CN101342318A (en) * | 2008-09-03 | 2009-01-14 | 青海省格拉丹东药业有限公司 | Medicament composition for nourishing blood, regulating menstruation and removing speckle, and preparation method thereof |
-
2014
- 2014-06-30 CN CN201410309888.7A patent/CN105288173B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985941A (en) * | 2005-12-19 | 2007-06-27 | 珠海天翼医药技术开发有限公司 | Preparing method of micropill of six Chinese medicine materials including glutinous rehmannia |
| CN101342318A (en) * | 2008-09-03 | 2009-01-14 | 青海省格拉丹东药业有限公司 | Medicament composition for nourishing blood, regulating menstruation and removing speckle, and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 国家药品监督管理局: "《<国家药品监督管理局国家中成药标准汇编中成药地方标准上升国家标准外科妇科分册》", 31 December 2002 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107050116A (en) * | 2016-11-23 | 2017-08-18 | 广州康臣药物研究有限公司 | It is a kind of to treat medicine pill of diabetic nephropathy and its preparation method and application |
| CN107823155A (en) * | 2017-11-21 | 2018-03-23 | 荆晓玉 | A kind of simple micropill and preparation method thereof |
| CN107823155B (en) * | 2017-11-21 | 2021-06-11 | 河南泓医药业有限公司 | Preparation method of single-medicine micro-pills |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105288173B (en) | 2018-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6091651B2 (en) | Pharmaceutical composition for treating headache and method for preparing the same | |
| CN1857690A (en) | Gynecopathy treating preparation and its preparing process | |
| CN103919887B (en) | A kind of Chinese medicine composition for the treatment of tumor and preparation method thereof | |
| CN102895478B (en) | Kidney-warming yang-supporting medicine composition and preparation method thereof | |
| CN103520572A (en) | Traditional Chinese composition used for treating atopic dermatitis as well as preparation method of composition | |
| CN103520293A (en) | Oral traditional Chinese medicine for improving and treating constipation | |
| CN1706463A (en) | Medicine for treating women's habitual abortion and threatened abortion | |
| CN102100758B (en) | Qingpeng gel for relieving pain and subdhing swelling and preparation method thereof | |
| CN101293063A (en) | Composition for treating climacteric syndrome, preparation and quality control method thereof | |
| CN102319398B (en) | Blood-nourishing and eyesight-improving Chinese medicinal composition and preparation method thereof | |
| CN105288173A (en) | Traditional Chinese medicine pellet preparation for regulating menstruation and removing freckles and preparation method thereof | |
| CN102000264A (en) | Composition for treating climacteric syndrome as well as preparation method and detection method thereof | |
| CN101677989A (en) | A drug composition for treatment and prevention of ischemic stroke and its preparation methods | |
| CN106038637A (en) | Pharmaceutical composition for treating breast cancer | |
| CN102895387B (en) | Kidney-yang-warming medicine composition, and preparation thereof and preparation method thereof | |
| CN102370901A (en) | Pharmaceutical composition for treating nephrosis and preparing process thereof | |
| CN103565987A (en) | Traditional Chinese medicine powder for treating silky coccidiosis | |
| CN105998697A (en) | Medicine composition for treating esophagus cancer | |
| CN104095994A (en) | Traditional Chinese medicine composition for removing chloasma, and preparation method of traditional Chinese medicine composition | |
| CN103720754A (en) | Drug release system and preparation method of multi-element micro pill used for unclogging arteries | |
| CN104740230A (en) | Silky fowl soft capsule and preparation method thereof | |
| CN111603501B (en) | Traditional Chinese medicine composition for primary liver cancer and application thereof | |
| CN108295221B (en) | Traditional Chinese medicine composition for treating Parkinson's disease and preparation method and application thereof | |
| CN105749044A (en) | Chinese herb preparation for treating chronic nephritis | |
| CN106729101B (en) | Traditional Chinese medicine composition for treating post-circulation ischemic stroke and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160316 Address after: 100176, No. 1, building 3, Cheng Cheng street, Beijing economic and Technological Development Zone, Beijing Applicant after: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Address before: 100176 Daxing District Zhongguancun science and Technology Park Daxing biomedical industry base 0501-32-1 block Applicant before: BEIJING SCRIANEN PHARMACEUTICAL Co.,Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Traditional Chinese medicine pellet preparation for regulating menstruation and removing freckles and preparation method thereof Effective date of registration: 20200122 Granted publication date: 20181123 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2020990000097 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210818 Granted publication date: 20181123 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2020990000097 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: The invention relates to a traditional Chinese medicine pellet preparation for regulating menstruation and freckle and a preparation method thereof Effective date of registration: 20210818 Granted publication date: 20181123 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2021990000732 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230330 Granted publication date: 20181123 Pledgee: Beijing Yizhuang International Financing Guarantee Co.,Ltd. Pledgor: BEIJING SILIAN PHARMACEUTICAL INDUSTRY Co.,Ltd. Registration number: Y2021990000732 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |