CN105288173B - A kind of the traditional Chinese medicine pellet preparation and preparation method of menstruation-regulating and speckle-dispelling - Google Patents
A kind of the traditional Chinese medicine pellet preparation and preparation method of menstruation-regulating and speckle-dispelling Download PDFInfo
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- CN105288173B CN105288173B CN201410309888.7A CN201410309888A CN105288173B CN 105288173 B CN105288173 B CN 105288173B CN 201410309888 A CN201410309888 A CN 201410309888A CN 105288173 B CN105288173 B CN 105288173B
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Abstract
A kind of the traditional Chinese medicine pellet preparation and preparation method of menstruation-regulating and speckle-dispelling, belong to the preparation technique of Chinese patent drug.It is characterized in that the pellet preparations are less than the pellet of 2.5mm by dried cream powder, crude drug powder and the microcrystalline cellulose of the effective component water extract by the partial size that following weight ratio forms：(effective component dried cream powder+crude drug powder)：Microcrystalline cellulose=1: 0.5-1.0.The present invention also provides the preparation methods of the pellet preparations.Inventor makes the traditional Chinese medicine pellet have many advantages, such as that drug release rate is fast, bioavilability is high, irritation is small, divided dose is accurate, take, is easy to carry by the research of production technology, the screening of supplementary product kind and quantity of solvent Ratio Experiments.By the update of dosage form, the high cost and security risks of the existing production technology of improvement, meet facilitation, the safe of enterprise's production technology, and provide for patient and take the more cheap new pharmaceutical formulation of more convenient, price.
Description
Technical field
The invention belongs to the preparation technique field of Chinese patent drug more particularly to the traditional Chinese medicine pellet preparations and system of a kind of menstruation-regulating and speckle-dispelling
Preparation Method.
Background technique
According to the interpretation of the cause, onset and process of an illness and the rules for the treatment of of Chinese medical discrimination, the ingredient of menstruation is mainly blood.So, qi and blood be it is mutual breed and project according to
Deposit, qi being the governor of blood, blood being the material foundation of QI, blood disease can and gas, gas disease can and blood, have extremely close relationship each other.Institute
It is the basic substance of menstruation with qi and blood, without qi and blood also there will be no menorrhea, irregular menstruation then necessarily occurs for disorder of qi and blood.
Qi and blood be internal organs biochemical, kidney controlling essence storage among internal organs, poly- congenital essence and hide it；The spleen being the foundation of acquired constitution, qi and blood biochemistry
Source, but can green blood often abided by with following.So, essence is biochemical, and blood can also be melted into essence, essence and blood sharing the same origin, mutually breeds, and with the heart, liver, spleen,
It mutually makes between the internal organs such as stomach and mutually assists, complement each other, just viscera function can be made normal, qi and blood is vigorous, and the wantonly two arteries and veins function of punching is strong, son
Palace " hiding, which is rushed down, section ", " storing the degree of having that overflows ", menstruation also can be painless.Biochemical insufficient if viscera function is not normal, thanks to then mistake is appointed in punching to qi and blood
In nourishing, two arteries and veins functional disturbances, the sea of blood cannot completely be full of on time or hemostasis, phlegm wet, the stagnation of the circulation of vital energy, so that functional activity of QI being not smooth, if liver and spleen gas is weak,
The Qi dysfunction in blood control or hot absurd row of blood that chases after can then cause advanced menorrhea, and hyper-menorrhea, menostaxis；Gas, anemia damage, kidney water deficiency, no
It can Rong Yan.Therefore irregular menstruation can derive color spot and dysmenorrhea etc..Modern medicine then thinks, irregular menstruation is mainly and endocrine function
Disorder, hormone metabolism are not normal related.
With Radix Astragali, Rehmannia glutinosa, eclipta, Radix Paeoniae Alba, glutinous rehmannia, Semen Cuscutae, the fruit of glossy privet, fructus lycii, Radix Angelicae Sinensis, the fleece-flower root, gymnadenia conopsea,
Peach kernel, radix bupleuri, donkey-hide gelatin, Chinese medicine made of safflower have the effect of nourishing blood for regulating menstruation, dissolving stasis and dispelling spots, can be used for nutrient QI and blood being insufficient, the stagnation of the circulation of vital energy
Blood stasis, menorrhalgia, chloasma etc..Specific parts by weight prescription is as follows：：Radix Astragali 35-45, Rehmannia glutinosa 25-35, eclipta 20-30,
Radix Paeoniae Alba 20-30, glutinous rehmannia 20-30, Semen Cuscutae 15-25, fruit of glossy privet 15-25, fructus lycii 15-25, Radix Angelicae Sinensis 15-25, fleece-flower root 15-
25, gymnadenia conopsea 15-25, peach kernel 10-20, radix bupleuri 10-20, donkey-hide gelatin 4-8, safflower 4-8.With Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Alba, radix rehmanniae preparata, donkey-hide gelatin,
The nourishing blood and invigorating qis such as gymnadenia conopsea, invigorating the spleen for eliminating dampness；Semen Cuscutae, the fruit of glossy privet, fructus lycii etc. tonify the liver and kidney, and liver blood kidney essense is sufficient, self energy China face
Beauty treatment, mind peace gas are refreshing；The fleece-flower root and radix bupleuri share can soothing liver-qi stagnation；Glutinous rehmannia and Eclipta prostrata share clear nourishing liver and kidney, clearing heat and cooling blood；Peach
Benevolence and safflower share promoting blood circulation.The effect of all medicines share plays nourishing blood for regulating menstruation altogether, dissolving stasis and dispelling spots.
The prescription Chinese patent drug only has 2 kinds of dosage forms such as capsule and tablet on the market at present.Capsule passes through the 4th medical university of army
Learn attached Xijing hospital, more than 70,000 example patient of Tang Dou hospital uses, it was demonstrated that the prescription is menstruation-regulating and speckle-dispelling drug of first choice curative for effect
Object, total effective rate are：Chloasma 94.6%, senile plaque 92%, irregular menstruation 96.4%, dysmenorrhea 96%, acne 76.5%.
It based on the good Clinical Basis of the prescription, but due to capsule and tablet, is not easy to swallow, is easy to the moisture absorption, stability
It is poor, it is not easy to store；In order to enrich dosage form kind, the good efficacy of the medicine is preferably played, the present inventor is carried out into one
Step research, is changed to micropill preparation, can not only preferably retain the curative effect of former preparation, and is swallowed compared with capsule and tablet more
Convenient, carrying, storage are also more convenient, and stability improves a lot.Pass through the research of production technology, the screening of supplementary product kind
With quantity of solvent Ratio Experiments, make the traditional Chinese medicine pellet have drug release rate is fast, bioavilability is high, irritation is small, divided dose is accurate,
The advantages that taking, be easy to carry.By the update of dosage form, the high cost and security risks of the existing production technology of improvement, meet
The facilitation of enterprise's production technology, safe, and provided for patient and take the more cheap new drug of more convenient, price
Dosage form.Meanwhile we establish more perfect quality standard, can be effectively controlled the quality of the kind.Through retrieving, said preparation still belongs to
Domestic blank.
Summary of the invention
The purpose of the present invention is to provide the traditional Chinese medicine pellet preparations and preparation method of a kind of menstruation-regulating and speckle-dispelling, and said preparation is by Huang
Stilbene, Rehmannia glutinosa, eclipta, Radix Paeoniae Alba, glutinous rehmannia, Semen Cuscutae, the fruit of glossy privet, fructus lycii, Radix Angelicae Sinensis, the fleece-flower root, gymnadenia conopsea, peach kernel, radix bupleuri, Ah
The Chinese medicinal compositions such as glue, safflower have the function of nourishing blood for regulating menstruation, dissolving stasis and dispelling spots, and clinical efficacy is significant, so due to capsule and tablet
More difficulty is swallowed, is easy to the moisture absorption, stability is poor, is clinically subject to certain restrictions, in order to enrich dosage form kind, preferably
The curative effect of the medicine is played, the applicant further studies it, has developed the micropill preparation of the Chinese patent drug, not only preferably
Remain the curative effect of the Chinese patent drug, and take, carry, storing more convenient, stability is also greatly improved.
Technical scheme is as follows：
A kind of traditional Chinese medicine pellet preparation of menstruation-regulating and speckle-dispelling, is made of the effective component of following parts by weight：Radix Astragali 35-45, radix rehmanniae preparata
Yellow 25-35, eclipta 20-30, Radix Paeoniae Alba 20-30, glutinous rehmannia 20-30, Semen Cuscutae 15-25, fruit of glossy privet 15-25, fructus lycii 15-25,
Radix Angelicae Sinensis 15-25, fleece-flower root 15-25, gymnadenia conopsea 15-25, peach kernel 10-20, radix bupleuri 10-20, donkey-hide gelatin 4-8, safflower 4-8, the Chinese medicine are micro-
The partial size that pill is made of dried cream powder, crude drug powder and the microcrystalline cellulose of the effective component water extract by following weight ratio
Pellet less than 2.5mm：(effective component dried cream powder+crude drug powder)：Microcrystalline cellulose=1: 0.5-1.0.
The traditional Chinese medicine pellet preparation is prepared：Take the fruit of glossy privet, fructus lycii, Radix Angelicae Sinensis, Radix Paeoniae Alba, radix bupleuri, donkey-hide gelatin, gymnadenia conopsea and
Safflower is ground into fine powder, and the seven flavor medicines material such as remaining Semen Cuscutae adds water to cook secondary, and every time plus 8-12 times is measured water, each to decoct 2 hours,
Collecting decoction, filtration, filtrate is concentrated into the thick paste that relative density is 1.30~1.35 (50 DEG C), is dried under reduced pressure, crushes, in addition
State crude drug powder and microcrystalline cellulose, weight ratio (effective component dried cream powder+crude drug powder)：Microcrystalline cellulose=1: 0.5-1.0 is mixed
It is even, with suitable water pill, by weight (effective component dried cream powder+crude drug powder+microcrystalline cellulose)：Distilled water=1: 0.2-
0.4, it is dry to get.
Preferably micropill preparation preparation method is：The fruit of glossy privet, fructus lycii, Radix Angelicae Sinensis, Radix Paeoniae Alba, radix bupleuri, donkey-hide gelatin, gymnadenia conopsea and safflower is taken to crush
At fine powder, the seven flavor medicines material such as remaining Semen Cuscutae adds water to cook secondary, each plus 10 times of amount water, respectively decoction 2 hours, collecting decoction,
Filtration, filtrate be concentrated into relative density be 1.30-1.35 (50 DEG C) thick paste, be dried under reduced pressure, crush, be added above-mentioned crude drug powder and
Microcrystalline cellulose, weight ratio (effective component dried cream powder+crude drug powder)：Microcrystalline cellulose=1: 0.5, it mixes, with suitable water system
Ball, by weight (effective component dried cream powder+crude drug powder+microcrystalline cellulose)：Distilled water=1: 0.3, it is dry to get.
Present inventor has performed a series of experiments, stable and controllable for quality to prove present invention process reasonable, to ensure
The beneficial effect of drug.
Experimental example 1：Extraction process is investigated
1, the investigation of medicinal material flour extraction
By prescription optimum proportioning parts by weight, Radix Paeoniae Alba 300g, fruit of glossy privet 240g, fructus lycii 240g, Radix Angelicae Sinensis 240g, gymnadenia conopsea are taken
240g, radix bupleuri 180g, donkey-hide gelatin 72g, safflower 60g, nominal take 3 parts, crush respectively, sieve with 100 mesh sieve, and carry out flour extraction investigation, knot
Fruit is shown in Table 1.
1 flour extraction investigation table of table
| Sample number into spectrum | Medicinal material amount (g) | Crude drug powder must measure (g) | Flour extraction (%) |
| 1 | 1572 | 1395 | 88.74 |
| 2 | 1572 | 1380 | 87.79 |
| 3 | 1572 | 1380 | 87.79 |
Above data shows that eight herbal medicine such as Radix Paeoniae Alba is ground into fine powder, and flour extraction is 85% or more.
2, the seven flavor medicines such as Radix Astragali material amount of water is investigated
By prescription optimum proportioning parts by weight, Radix Astragali 16g, Rehmannia glutinosa 12g, eclipta 10g, glutinous rehmannia 10g, Semen Cuscutae are taken
8g, fleece-flower root 8g, peach kernel 6g, nominal take 3 parts of samples.Respectively plus 8,10,12 times of amounts decoctions of water are secondary, and 2 hours every time, filtration,
Merging filtrate, concentration, is dried under reduced pressure.In view of the above medicinal material, Radix Astragali mainly contains saponin component, and Semen Cuscutae mainly contains Huang
Ketone, coumarin, terpenoid compound, eclipta mainly contain tannin, amaroid, flavones, isoflavone aglycone and composition of alkaloids, what
The tuber of multiflower knotweed mainly contains anthraquinone component, and glutinous rehmannia mainly contains iridoid glycoside constituents, and peach kernel mainly contains amarogentin, sterol
With sterol methods of glycosides, the above ingredient is dissolved in n-butanol, therefore using the total amount of n-butanol extract as index, amount of water is carried out
It is preferred that.N-butanol extract content in 3 extracts is determined by the following procedure：Extract dried cream powder about 3g is weighed respectively, it is accurate
It is weighed, it sets in the conical flask of 100ml, the accurate methanol 50ml measured, close plug, weighed weight, after standing 1 hour, in water is added
Reflux is heated to boiling in bath, and is kept for slightly boiled 1 hour.After letting cool, conical flask, close plug are removed, weighed weight is supplied with methanol
The weight of less loss, shakes up, with dry filter filtration.Precision measures subsequent filtrate 25ml, is evaporated, and residue 30ml water dissolves, and uses water
The n-butanol of saturation extracts 4 times (30ml, 30ml, 20ml, 20m1), and combined extract is set in the evaporating dish for dried weight and steamed
Dry, residue is 3 hours dry in 105 DEG C, 30 minutes cooling in dislocation drier, rapid accurately weighed weight.It is calculated with drying bottle
The radiotherapy of n-butanol extract, the results are shown in Table 2 in test sample.
2 amount of water of table investigates result table
| Sample number into spectrum | Amount of water | Paste volume (g) | N-butanol extract amount (g/ parts) |
| 1 | 8 times of amounts | 23.5 | 1.12 |
| 2 | 10 times of amounts | 25.7 | 1.16 |
| 3 | 12 times of amounts | 27.4 | 1.14 |
Table 2 the result shows that, add 8,10,12 times of amount n-butanol extract amount difference of water little, consider from production is practical, therefore really
Fixed optimal amount of water is 10 times of amounts.
2 preparations shaping technical study of experimental example
1, the selection of supplementary product kind
Starch, dextrin and microcrystalline cellulose are carried out respectively preferred.By best prescription parts by weight take medicinal powder (including extract
Object dried cream powder and crude drug powder) 150g, 3 parts are divided into, appropriate amount of starch, dextrin and microcrystalline cellulose are separately added into, it is after mixing plus suitable
Amount distilled water prepares pellet respectively, the results are shown in Table 3.
The selection result table of 3 supplementary product kind of table
Table 3 is the results show that microcrystalline cellulose is easier to pill as auxiliary material, therefore determination uses microcrystalline cellulose as the tax of pellet
Shape agent.
2, the selection of microcrystalline cellulose dosage
Drug (including extract dried cream powder and crude drug powder) 300g is taken by best prescription amount parts by weight, 3 parts is divided into, adds
Enter appropriate microcrystalline cellulose and distilled water pill, it is dry, using the moisture absorption of pill complexity and pellet as inspection target, knot
Fruit is shown in Table 4.
The 4 preferred table of microcrystalline cellulose dosage of table
Table 4 can be made into molding well the results show that 0.5 times of microcrystalline cellulose of addition, be not easy the pellet of the moisture absorption, therefore select
It selects and 0.5-1.0 times of the medicinal powder microcrystalline cellulose measured is added.
3, the dosage selection of wetting agent
This product selects distilled water cheap and easy to get to make wetting agent.Fixed pellet prescription medicinal powder：Auxiliary material is 1: 0.5, is added not
Water in proportion is made softwood, pill (hole diameter of sieve (perforated) plate 1.0mm, extruded velocity 30rpm, round as a ball speed 50Hz, round as a ball time
For 2min).The yield and roundness for measuring pellet, the results are shown in Table 5.
The calculating of yield：Pellet obtained is sieved, with 16~40 mesh pellets compared with inventory, calculated yield shows
The complexity of pellet preparation.
The calculating of roundness：Roundness is one of important indicator of pellet, reflects pellet into spherical quality, direct shadow
Ring the quality and drug release feature of pellet.The roundness of pellet is evaluated with trait index, i.e., takes out 20 sieving pellets at random,
(17 × 16) measure its maximum diameter and most path under optical microscopy, and the circle of pellet is evaluated with the ratio of maximum diameter and most path
Whole degree, the two ratio is smaller, and roundness is better.
Influence of the 5 wetting agent dosage of table to pellet
| Sample number into spectrum | Distilled water (%) | Yield (%) | Roundness |
| 1 | 20 | 75 | 0.75 |
| 2 | 30 | 81 | 0.86 |
| 3 | 40 | 74 | 0.75 |
Table 5 is the results show that when low moisture content, and extrudate intensity is high, and plasticity is poor, not at spherical shape；It is short when moisture content is high
Cylinder is easy mutually bonding after being rolled into spherical shape, reduces yield.Therefore determine that amount of water is 30%.
4, the selection of hole diameter of sieve (perforated) plate
This product preparations shaping technical study investigates hole diameter of sieve (perforated) plate, fixed pellet prescription and other process conditions
(add 0.5 times of amount microcrystalline cellulose, 30% water softwood, it is 30rpm that agent, which goes out speed, round as a ball speed 50Hz, and the round as a ball time is
2min), pellet is prepared with different holes diameter of sieve (perforated) plate, the results are shown in Table 6.
6 hole diameter of sieve (perforated) plate Selection experiment result table of table
In addition table 6 considers that medication is convenient and product appearance the results show that hole diameter of sieve (perforated) plate does not make significant difference to pellet molding,
Therefore select hole diameter of sieve (perforated) plate more satisfactory for the product of 1.0mm.
5, the selection of round as a ball speed
Fixed pellet prescription and other process conditions (add 0.5 times of amount microcrystalline cellulose, 30% water softwood, hole diameter of sieve (perforated) plate
1.0mm, it is 30rpm that agent, which goes out speed, and the round as a ball time is 2min), pellet is prepared with different round as a ball speed, the results are shown in Table 7.
The round as a ball speed Selection experiment result table of table 7
| Sample number into spectrum | Round as a ball speed (Hz) | Yield (%) | Roundness |
| 1 | 30 | 76 | 0.75 |
| 2 | 40 | 85 | 0.85 |
| 3 | 50 | 81 | 0.84 |
For table 7 the results show that when round as a ball speed 40Hz, the roundness of pellet is high, and yield is also preferable, therefore selects round as a ball speed
For 40Hz.
6, the selection of round as a ball time
Fixed pellet prescription and other process conditions (add 0.5 times of amount microcrystalline cellulose, 30% water softwood, hole diameter of sieve (perforated) plate
1.0mm, it is 30rpm that agent, which goes out speed, and round as a ball speed is 40Hz), pellet sample is taken from the different round as a ball time, measures the circle of pellet
Whole degree, the results are shown in Table 8.
The round as a ball selection of time test result table of table 8
| Round as a ball time (min) | Roundness |
| 2 | 0.85 |
| 4 | 0.85 |
| 6 | 0.86 |
| 8 | 0.83 |
| 10 | 0.83 |
After table 8 is the results show that the round as a ball time is more than 2min, the roundness variation of pellet less, therefore selects the round as a ball time extremely
It is less 2min.
Specific embodiment
The optimum implementation of the invention is：It is best available to be in parts by weight at being grouped as：Radix Astragali 40, Rehmannia glutinosa 30,
Eclipta 25, Radix Paeoniae Alba 25, glutinous rehmannia 25, Semen Cuscutae 20, the fruit of glossy privet 20, fructus lycii 20, Radix Angelicae Sinensis 20, the fleece-flower root 20, gymnadenia conopsea 20, peach kernel
15, radix bupleuri 15, donkey-hide gelatin 6, safflower 5.By the parts by weight of effective component take the fruit of glossy privet, fructus lycii, Radix Angelicae Sinensis, Radix Paeoniae Alba, radix bupleuri, Ah
Glue, gymnadenia conopsea and safflower crush, and sieve with 100 mesh sieve up to crude drug powder.Radix Astragali, Semen Cuscutae, ink drought are taken by the parts by weight of effective component
Lotus, the fleece-flower root, glutinous rehmannia, Rehmannia glutinosa and peach kernel, add water to cook it is secondary, 2 hours every time, every time plus 10 times of amount water, collecting decoction, filter
It crosses, filtrate is concentrated into the thick paste that relative density is 1.30~1.35 (50 DEG C), is dried under reduced pressure, and crushes, sieves with 100 mesh sieve to get having
Imitate ingredient dried cream powder.By (effective component dried cream powder+crude drug powder)：Microcrystalline cellulose=1: 0.5 weight ratio takes and sieves with 100 mesh sieve
Microcrystalline cellulose, mixed with above-mentioned crude drug powder and effective component dried cream powder, by weight (effective component dried cream powder+crude drug powder+
Microcrystalline cellulose)：Distilled water=1: 0.3, which is added distilled water, is made mixing softwood, uses extrusion-spheronization pellet, sieve plate hole
Diameter is 1.0mm, and extruded velocity 30rpm, round as a ball speed 40Hz, the round as a ball time is that pellet made from 2min. is small in 60 DEG C of dryings 8
When to get finished product pellet.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the technical principles of the invention, several improvements and modifications, these improvements and modifications can also be made
Also it should be regarded as protection scope of the present invention.
Claims (5)
1. a kind of traditional Chinese medicine pellet preparation of menstruation-regulating and speckle-dispelling, is made of the effective component of following parts by weight：Radix Astragali 35-45, Rehmannia glutinosa
25-35, eclipta 20-30, Radix Paeoniae Alba 20-30, glutinous rehmannia 20-30, Semen Cuscutae 15-25, fruit of glossy privet 15-25, fructus lycii 15-25, when
Return 15-25, fleece-flower root 15-25, gymnadenia conopsea 15-25, peach kernel 10-20, radix bupleuri 10-20, donkey-hide gelatin 4-8, safflower 4-8, it is characterised in that：
The traditional Chinese medicine pellet preparation is dried cream powder, crude drug powder and microcrystalline cellulose by the effective component water extract by following weight ratio group
At partial size be less than 2.5mm pellet, (effective component dried cream powder+crude drug powder)：Microcrystalline cellulose=1：0.5-1.0；
The preparation method of the traditional Chinese medicine pellet preparation of the menstruation-regulating and speckle-dispelling includes the following steps：
(1) Radix Astragali, Semen Cuscutae, eclipta, the fleece-flower root, glutinous rehmannia, Rehmannia glutinosa and peach kernel are taken by the parts by weight of effective component, adds water
It decocts 2 times, 2 hours every time, each amount of water was the water of 8-12 times of weight, and decocting liquid filtration merges, is concentrated under reduced pressure, is dried under reduced pressure,
Crush the dried cream powder that effective component water extract is made；
(2) fruit of glossy privet, fructus lycii, Radix Angelicae Sinensis, Radix Paeoniae Alba, radix bupleuri, donkey-hide gelatin, gymnadenia conopsea and safflower is taken to crush by the parts by weight of effective component
At crude drug powder；
(3) crude drug powder and microcrystalline cellulose that the dried cream powder that obtains by step (1), step (2) obtain sieve with 100 mesh sieve respectively, press
Weight ratio (effective component dried cream powder+crude drug powder)：Microcrystalline cellulose=1：0.5-1.0 mixing, and by weight (effective component is dry
Cream powder+crude drug powder+microcrystalline cellulose)：Distilled water=1：0.2-0.4 is added distilled water and mixing softwood is made；
(4) it is squeezed out with the mixing softwood that extrusion-spheronization pelletizing machine obtains step (3), is round as a ball, it is micro- less than 2.5mm to obtain partial size
Ball, pellet are placed in 60 DEG C of dryings in baking oven, finally cross sieve classification, and obtain medical treatment nutrient QI and blood being insufficient, qi depression to blood stasis, menorrhalgia, yellow
The traditional Chinese medicine pellet preparation of foxiness；
The granulation conditions of extrusion-spheronization pelletizing machine described in step (4) are：Hole diameter of sieve (perforated) plate is 1.0mm, and round as a ball speed is 40Hz, rolling
It is 2min between bowlder.
2. the traditional Chinese medicine pellet preparation of a kind of menstruation-regulating and speckle-dispelling according to claim 1, by the group of effective components of following parts by weight
At：Radix Astragali 40, Rehmannia glutinosa 30, eclipta 25, Radix Paeoniae Alba 25, glutinous rehmannia 25, Semen Cuscutae 20, the fruit of glossy privet 20, fructus lycii 20, Radix Angelicae Sinensis 20,
The fleece-flower root 20, gymnadenia conopsea 20, peach kernel 15, radix bupleuri 15, donkey-hide gelatin 6, safflower 5, it is characterised in that：The traditional Chinese medicine pellet preparation is that had by described
Dried cream powder, crude drug powder and the microcrystalline cellulose for imitating ingredient water extract are less than the pellet of 2.5mm by the partial size of following weight ratio composition,
(effective component dried cream powder+crude drug powder)：Microcrystalline cellulose=1：0.5-1.0.
3. the preparation method of the traditional Chinese medicine pellet preparation of menstruation-regulating and speckle-dispelling of any of claims 1 or 2, it is characterised in that：Preparation step
It is as follows：
(1) Radix Astragali, Semen Cuscutae, eclipta, the fleece-flower root, glutinous rehmannia, Rehmannia glutinosa and peach kernel are taken by the parts by weight of effective component, adds water
It decocts 2 times, 2 hours every time, each amount of water was the water of 8-12 times of weight, and decocting liquid filtration merges, is concentrated under reduced pressure, is dried under reduced pressure,
Crush the dried cream powder that effective component water extract is made；
(2) fruit of glossy privet, fructus lycii, Radix Angelicae Sinensis, Radix Paeoniae Alba, radix bupleuri, donkey-hide gelatin, gymnadenia conopsea and safflower is taken to crush by the parts by weight of effective component
At crude drug powder；
(3) crude drug powder and microcrystalline cellulose that the dried cream powder that obtains by step (1), step (2) obtain sieve with 100 mesh sieve respectively, press
Weight ratio (effective component dried cream powder+crude drug powder)：Microcrystalline cellulose=1：0.5-1.0 mixing, and by weight (effective component is dry
Cream powder+crude drug powder+microcrystalline cellulose)：Distilled water=1：0.2-0.4 is added distilled water and mixing softwood is made；
(4) it is squeezed out with the mixing softwood that extrusion-spheronization pelletizing machine obtains step (3), is round as a ball, it is micro- less than 2.5mm to obtain partial size
Ball, pellet are placed in 60 DEG C of dryings in baking oven, finally cross sieve classification, and obtain medical treatment nutrient QI and blood being insufficient, qi depression to blood stasis, menorrhalgia, yellow
The traditional Chinese medicine pellet preparation of foxiness；
The granulation conditions of extrusion-spheronization pelletizing machine described in step (4) are：Hole diameter of sieve (perforated) plate is 1.0mm, and round as a ball speed is 40Hz, rolling
It is 2min between bowlder.
4. the preparation method of the traditional Chinese medicine pellet preparation of menstruation-regulating and speckle-dispelling according to claim 3, it is characterised in that：Step (1)
The reduced pressure is pressure 0.06mpa, is concentrated under the conditions of temperature 60 C.
5. the preparation method of the traditional Chinese medicine pellet preparation of menstruation-regulating and speckle-dispelling according to claim 3, it is characterised in that：Step (1)
Described is dried under reduced pressure the drying 8 hours under the conditions of temperature is 80 DEG C for pressure -0.1mpa.
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| CN1985941A (en) * | 2005-12-19 | 2007-06-27 | 珠海天翼医药技术开发有限公司 | Preparing method of micropill of six Chinese medicine materials including glutinous rehmannia |
| CN101342318A (en) * | 2008-09-03 | 2009-01-14 | 青海省格拉丹东药业有限公司 | Medicament composition for nourishing blood, regulating menstruation and removing speckle, and preparation method thereof |
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| CN1985941A (en) * | 2005-12-19 | 2007-06-27 | 珠海天翼医药技术开发有限公司 | Preparing method of micropill of six Chinese medicine materials including glutinous rehmannia |
| CN101342318A (en) * | 2008-09-03 | 2009-01-14 | 青海省格拉丹东药业有限公司 | Medicament composition for nourishing blood, regulating menstruation and removing speckle, and preparation method thereof |
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