CN105287646A

CN105287646A - Solution preparation for detecting and relieving or eliminating oral inflammation, combination product and application thereof

Info

Publication number: CN105287646A
Application number: CN201410250997.6A
Authority: CN
Inventors: 潘申权
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-06-07
Filing date: 2014-06-07
Publication date: 2016-02-03

Abstract

The invention provides a solution preparation for detecting oral inflammation or degree of cleanliness, relieving and/or eliminating oral inflammation, and/or cleaning an oral cavity, a combination product for detecting oral inflammation degree of a mammal and relieving and/or eliminating oral inflammation, and application of a tannin solution in preparation of products for detecting oral inflammation degree, relieving or eliminating oral inflammation, detecting oral cleanliness degree, and/or cleaning the oral cavity. The invention also provides application of the solution preparation and the combination product in preparation of products for detecting the oral inflammation degree, relieving or eliminating the oral inflammation, detecting the oral cleanliness degree, and/or cleaning the oral cavity.

Description

Detect and alleviate or remove the pharmaceutical solutions of oral inflammation, combination product and application thereof

Technical field

The invention belongs to medical examination and field of oral care, specifically, the present invention relates to the pharmaceutical solutions of detection fast and alleviation or removing oral inflammation, combination product and application thereof.

Background technology

People often brush teeth twice every day sooner or later, and many people also clean one's teeth on schedule, but a lot of people also has oral problem, as problems such as periodontitis, dental caries, oral ulcer and halitosiss.

Oral ulcer, is commonly called as oral cavity and gets angry, directly affect work efficiency.One to work strain and busy time, will BAIPAO be played in the oral cavity of a lot of people, allow people's hurt like hell.This both affected task efficiency, perplexed again the mood of people.Recurrent oral ulceration annoyings a lot of crowd, its unknown etiology as yet.

Oral inflammation affects the curative effect of multiple oral medical measure (as plantation, correction).The patient that oral inflammation is heavier, often after plantation or correction, its medical effect is not ideal enough, even causes malpractice.Lowering and controlling oral inflammation is the prerequisite of carrying out the medical measures such as plantation and correction.

Periodontitis not only can cause loosening and coming off of tooth, and affects whole healthy.Periodontitis and major disease (as heart disease, diabetes and old apoplexy) closely related, be also considered to after cancer and heart disease, threaten the third-largest killer of human health.The order of severity of periodontitis in different patient differs widely; Effect after periodontal scaling is also limited by the host immunity function that can not control.

Halitosis is a problem making people very awkward.Pay attention to the modern society of personal image at this, halitosis directly affects the work relationship of getting along with other people, also affects self-confidence and the image of individual.Everyone does not wish have any mishap and defect on this problem.Halitosis often annoyings a lot of people on the hop.

These different oral problem have a common feature: they have a kind of be difficult to predict uncertainty.This illustrates that there is a kind of X factor in oral cavity is affecting oral health.

Up-to-date research finds: also exist in oral cavity a kind of before not the inflammation understood by the mankind originate; This newfound oral inflammation is originated the multiple oral problem directly affected in oral cavity.Source, this new oral cavity is referred to as " stomatitis speckle " (OralInflammatoryPlague) and " stomatitis knot " (OralInflammatoryKnotitis) (specifically see Chinese invention patent 2010101094421).

People often only clean tooth.If other position is not cleaned in the oral cavity accounting for greater part, food debris and bacterial adsorption can be caused, remain in and be not easy by the oral soft tissue that cleans, thus form the source of oral inflammation.Oral inflammation is the incitant of oral ulcer, periodontitis and other oral disease.

The oral inflammation source of this new cognition occurs in the soft tissue position that cavity interior is not easy cleaning, mainly appear at the position, oral cavity that existing oral appliance can not effectively be cleared up, as the intersection of (1) gingiva root and oral cavity wall, the i.e. close region of " mucosa gum circle " (mucogingivaljunction), (2) oral cavity wall, (3) root of the tongue inwall, (4) tongue bottom, and (5) oral cavity and tongue intersection.

Because above-mentioned position can not be cleared up effectively, different materials deposits at this, and this comprises antibacterial and food waste.These deposits can bring out the immunocyte of human body, particularly neutrophils (Neutrophil), assemble this place in a large number.But these immunocytes are cannot remove that these have hardened sedimental.These immunocytes discharge multiple catabolic enzyme and toxicant (Milleretal1984; Kantarcietal2003), and immune response signal, thus bring out inflammatory reaction (Wrightetal1986; Cassatella2003; Serhan & Savill2005), thus form " stomatitis speckle " (OralInflammatoryPlague).

The existence of stomatitis speckle will bring out the Soft Tissue Deformation of periphery, is wrapped in wherein by stomatitis speckle.Because region of interest can not effectively be cleared up, new precipitate continues deposition at this, thus brings out the formation of more stomatitis speckle.Soft tissue around also will be out of shape, and be encased by these stomatitis speckles, a large amount of gatherings of stomatitis speckle, will be formed " stomatitis knot " (OralInflammatoryKnotitis).

Inflammation a kind ofly tackles infection, damage or the important immunoreation of various deleterious condition.Inflammatory process is very important concerning body, because it is served reparation damage, kills and wounds in the process of pathogenic microorganism and tumor.But lasting inflammation is harmful, because the enzyme of inflammatory cell release toxic molecule and infringement normal cell and tissue.

Non-solution inflammation (non-resolvinginflammation) is a kind of main drive of disease, it promotes the pathological process of various diseases significantly, and described disease comprises: atherosclerosis, diabetes, obesity, cancer, chronic obstructive pulmonary disease, asthma, inflammatory bowel disease, neurodegenerative diseases, multiple sclerosis or rheumatoid arthritis are fallen ill.

Detect inflammatory process is very important concerning doctor, because its appearance means the existence of major disease, injury or deleterious condition.Exemplary disorders often with extensive inflammation feature has: myocardial infarction, active tuberculosis, osteomyelitis (infection of bone), rheumatoid arthritis, cholecytistis (infection gallbladder) and pyelonephritis (kidney infection) and cancer diffusion.

The patient suffering from obvious inflammation often shows well-known inflammatory signs and symptom, as fever, weak and inappetence.But these sings and symptomses are insensitive, the existence that also do not show inflammation specifically both.More specifically, before diagnosable disease occurs, inflammatory reaction can be there is in some disease and health.Therefore, detect the appearance of inflammatory symptom, these diseases of Diagnosis and Treat and discomfort more in time will be conducive to.

The most famous and the most widely used blood inflammation Testing index is erythrocyte sedimentation rate or ESR at present.ESR is found by Fahraeus, Wintrobe and Westergren improves and promote, the Wei Shi blood sedimentation rate formed or WESR, thoughts on the overall rising of inflammatory protein, measures the distance of erythrocyte sedimentation in 60 minutes.Doctors once attempted to develop other more easily or faster or more responsive or concrete inflammation detection method.These detections comprise c reactive protein or CRP, numeration of leukocyte, orosomucoid albumen, erythrocyte or hemoglobin and Fibrinogen (with reference to U.S. Patent number 5137832, U.S. Patent number 4843869, U.S. Patent number 5506145).

But for oral cavity, oral cavity is the environment come with blood separating, and the level of inflammation in blood can not be reflected in the situation of oral inflammation.Therefore, current blood inflammation detection method can not be used for for the diagnosis at oral inflammation.

Oral cavity is the passage entered in human body, and many events occur at this.Oral cavity accepts food, and is diminished by the food particle of solid, mixes with saliva, starts digestion process.Oral mucosa and saliva glandular secretion provide lubricating fluid, help verbalization, swallow and food digestion.Therefore, oral cavity is especially easily infected, is damaged or various deleterious condition.In addition, have in oral cavity and a set ofly distinctively occur in intraoral disease and discomfort, comprise dental caries, periodontal, oral ulcer etc.Some situation as bad olfactory sensation, halitosis, even snoring also may be relevant with oral health.Inflammatory reaction caused by different reason may appear in mouth simultaneously.The inflammatory factor of separate sources may influence each other between different event, because may form an interactional level in an environment that local is shared relatively.This should be different from body inner blood environment.

The oral inflammation level detection method developed in the past is mainly based on the neutrophils cell number detected in oral cavity (with reference to Chinese Patent Application No. 201010588508X), and its testing process is relatively long, also more loaded down with trivial details.Therefore, existing market in the urgent need to detecting oral inflammation degree fast, and is alleviated simultaneously or removes the method for oral inflammation, so as numerous medical personnel and consumer easy to use, detect in time and alleviate or remove oral inflammation.

Summary of the invention

For contributing to understanding the present invention, define some terms below.Unless otherwise indicated, the term occurred herein has the implication that those of ordinary skill in the related art of the present invention understand usually.

Unless otherwise indicated, term used herein " oral inflammation " refers to the inflammation occurred in oral cavity.In this application, described " oral inflammation " comprises and reacts brought out pathological changes by oral inflammation, comprise oral ulcer, periodontitis, halitosis, snoring, the sense of taste or olfactory sensation pathological changes, wrinkle and/or shape of face pathological changes.The source of bringing out " oral inflammation " comprises " the stomatitis speckle " and " stomatitis knot " that occur in cavity interior, embedding oral cavity mucous membrane tissue.

Unless otherwise indicated, term used herein " stomatitis speckle " refers to the gathering colony embedding the human immunocyte that the deposit in oral cavity mucous membrane tissue brings out.In this application, described " stomatitis knot " refers to the site embedding the numerous stomatitis speckles in oral cavity mucous membrane tissue and assemble.

Unless otherwise indicated, term used herein " oral inflammation degree " refers to the degree of inflammation occurred in oral cavity.In this application, the sedimentary amount of polymerism that described " oral inflammation degree " is specifically formed by gargling with the pharmaceutical solutions containing tannin represents, may be used for the existence of mammalian mouth inflammation described in auxiliary judgment whether, the order of severity and/or improvement situation.

Unless otherwise indicated, term used herein " oral cleaning level " refers to the clean-up performance of cavity interior.In this application, the sedimentary amount of polymerism that described " oral cleaning level " is specifically formed by gargling with the pharmaceutical solutions containing tannin represents, and may be used for mammalian mouth described in auxiliary judgment and cleans situation.

Unless otherwise indicated, term used herein " oral inflammation index " refers to the quantizating index of the degree of inflammation occurred in oral cavity.In this application, the relative level representative of the sedimentary amount of polymerism that described " oral inflammation index " is specifically formed by gargling with the pharmaceutical solutions containing tannin, may be used for the existence of mammalian mouth inflammation described in auxiliary judgment whether, the order of severity and/or improvement situation.

Unless otherwise indicated, the increased times of the sedimentary amount of polymerism that term used herein " personalized oral inflammation index " is formed by gargling with tanning solution preparation in detected object oral cavity represents, the computing formula of this index is as follows:

I _i＝P _t/P _h

I wherein _ifor the oral inflammation index of personalization; P _tfor gargling with tanning solution preparation from detected object and the sedimentary amount of polymerism formed; P _hfor the sedimentary amount of polymerism that this detected object is gargled with tanning solution preparation under the health condition of NIP and formed.

Unless otherwise indicated, the sedimentary amount of polymerism that term used herein " comparative oral inflammation index " is formed by gargling with tanning solution preparation of detected object, relative to the increased times of the health reference person of NIP.The computing formula of this index is as follows:

I _c＝P _t/P _r

I wherein _cfor comparative oral inflammation index; P _tfor gargling with tanning solution preparation from detected object and the sedimentary amount of polymerism formed; P _rthe sedimentary amount of polymerism formed for the gargling with tanning solution preparation of health reference person of NIP.According to a specific embodiment of the present invention, the gargling with tanning solution preparation of health reference person of NIP and the sedimentary amount (P of polymerism formed _r) be set as 1.

In order to solve the problems of the technologies described above, an object of the present invention is to provide a kind of for detecting oral inflammation degree and the pharmaceutical solutions of alleviation and/or removing oral inflammation.

Another object of the present invention is to provide a kind of for detecting mammalian mouth degree of inflammation and the combination product of alleviation and/or removing oral inflammation.

Another object of the present invention is to provide tannin solution for the preparation of 1) detect oral inflammation degree and/or 2) alleviate or remove the application in the product of oral inflammation.

Further object of the present invention is to provide foregoing pharmaceutical solutions or described test kit or combination product for the preparation of 1) detect oral inflammation degree and/or 2) alleviate or remove the application in the product of oral inflammation.

An also object of the present invention is to provide for detecting oral cleaning level and the pharmaceutical solutions of cleaning oral cavity.

Another object of the present invention is to provide the combination product for detecting mammalian mouth clean-up performance cleaning oral cavity.

Another object of the present invention is to provide tannin solution for the preparation of 1) detect oral cleaning level and/or 2) application in the product of cleaning oral cavity.

Another object of the present invention is to provide foregoing pharmaceutical solutions or described test kit or combination product for the preparation of 1) detect oral cleaning level and/or 2) application in the product of cleaning oral cavity.

Particularly, above object of the present invention is achieved through the following technical solutions:

On the one hand, the invention provides a kind of for detecting oral inflammation degree and the pharmaceutical solutions of alleviation and/or removing oral inflammation, described solution comprises:

Tannin, English by name: tannin, described tannin comes from plant extract or synthetic; With

One or more are for suppressing or kill the medicine of oral microorganism, and preferably, described suppression or the medicine killing oral microorganism are: chlorhexidine gluconate hydrochlorate.Chlorhexidine gluconate has another name called chlorhexidine gluconate, English by name:

3-methyl-4-(1-methylethyl)phenoltetraazatetradecanediimidamide(2:1)hibitanegluconate。

Further preferably, described suppression or the medicine that kills oral microorganism are: DP300 (2,4,4 '-trichloro-2 '-hydroxydiphenylether).

Preferably, according to foregoing pharmaceutical solutions, described pharmaceutical solutions comprises further:

Organic solvent, described organic solvent be preferably ethanol, dimethyl sulfoxide and other effective and safe have in agent solvent one or more;

For regulating the compound of the taste of this pharmaceutical solutions, the compound of the described taste for regulating this pharmaceutical solutions is preferably sucralose or sodium chloride; And/or

For painted compound, described compound is preferably phenol red sodium or beet red.

Preferably, according to foregoing pharmaceutical solutions, described tannin comes from plant extract; Further preferably, described plant be selected from tea, Fructus Lycopersici esculenti, Fructus Mali pumilae, Lee, Fructus Vitis viniferae or other contain trees or the fruit of tannin.

Further preferably, according to foregoing pharmaceutical solutions, described pharmaceutical solutions, in often liter of solution, comprises: 1-300 gram of ethanol, 1-100 gram of tannin, 0.01-1.00 gram of chlorhexidine gluconate, 0.01-1.00 gram of sucralose and 0.01-0.02 gram of phenol red sodium;

More preferably, described pharmaceutical solutions, in often liter of solution, comprises: 30-100 gram of ethanol, 7-30 gram of tannin, 0.1-0.2 gram of chlorhexidine gluconate, 0.01-0.3 gram of sucralose and 0.011 gram of phenol red sodium.

Further preferably, according to foregoing pharmaceutical solutions, described pharmaceutical solutions is aqueous solution or glucose solution; More preferably, the concentration of the glucose in described glucose solution is 1-150 grams per liter.

On the other hand, the invention provides a kind of for detecting mammalian mouth degree of inflammation and the combination product of alleviation and/or removing oral inflammation, described mammal is preferably people, and described combination product is preferably test kit, and this combination product comprises:

Foregoing pharmaceutical solutions; With

For detecting instrument and/or the utensil at stomatitis speckle and stomatitis knot position, place in mouth of bringing out oral inflammation; Preferably, described instrument and/or napkin bag contain: main body, cervical region and head, arrange can tie with stomatitis the function part fully contacted with stomatitis speckle at its head; Further preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush and wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body, cervical region and head, and the strigil of pharmaceutical solutions or mastic can be carried, described strigil covers on head, can to tie fully contact with stomatitis speckle with stomatitis.

Preferably, according to foregoing test kit or combination product, described test kit or combination product comprise instrument for removing the stomatitis speckle that brings out oral inflammation and stomatitis knot and/or utensil further;

More preferably, described instrument and/or napkin bag contain: main body, cervical region and head, arrange the function part that can loosen and remove stomatitis speckle and stomatitis knot at its head;

Again preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of pharmaceutical solutions or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis.

Another aspect, the invention provides tannin solution for the preparation of 1) detect oral inflammation degree and/or 2) alleviate or remove the application in the product of oral inflammation.

Also on the one hand, the invention provides foregoing pharmaceutical solutions or described combination product for the preparation of 1) detect oral inflammation degree and/or 2) alleviate or remove the application in the product of oral inflammation.

Preferably, according to foregoing application, described oral inflammation comprises and reacts brought out pathological changes by oral inflammation, preferably from oral ulcer, periodontitis, halitosis, snoring, the sense of taste or olfactory sensation pathological changes, wrinkle and/or shape of face pathological changes.

On the other hand, the invention provides a kind of for detecting oral cleaning level and the pharmaceutical solutions of cleaning oral cavity, described solution comprises:

One or more are for suppressing or kill the medicine of oral microorganism;

Preferably, described suppression or the medicine that kills oral microorganism are: chlorhexidine gluconate hydrochlorate.Chlorhexidine gluconate has another name called chlorhexidine gluconate, English by name:

3-methyl-4-(1-methylethyl)phenoltetraazatetradecanediimidamide(2:1)hibitanegluconate；

Or preferably, described suppression or the medicine killing oral microorganism are: DP300 (2,4,4 '-trichloro-2 '-hydroxydiphenylether).

On the other hand, the invention provides a kind of combination product for detecting mammalian mouth clean-up performance cleaning oral cavity, described mammal is preferably people, and described combination product is preferably test kit, and this combination product comprises:

Foregoing pharmaceutical solutions; With

Another aspect, the invention provides tannin solution for the preparation of 1) detect oral cleaning level and/or 2) application in the product of cleaning oral cavity.

Also on the one hand, the invention provides foregoing pharmaceutical solutions or described combination product for the preparation of 1) detect oral cleaning level and/or 2) application in the product of cleaning oral cavity.

Another aspect, the invention provides and a kind ofly detect mammalian mouth degree of inflammation and alleviate or remove the method for oral inflammation, and described method comprises gargles with above-mentioned pharmaceutical solutions and the polymerism precipitate that formed; Preferably, described oral inflammation degree is oral inflammation index; Preferably, described oral inflammation index is personalized oral inflammation index or comparative oral inflammation index; Preferably, described mammal is people.

Also on the one hand, the invention provides a kind of method detecting mammalian mouth degree of inflammation, described method comprises gargles with above-mentioned pharmaceutical solutions and the polymerism precipitate that formed; Preferably, described oral inflammation degree is oral inflammation index; Preferably, described oral inflammation index is personalized oral inflammation index or comparative oral inflammation index; Preferably, described mammal is people.

Wherein, said method preferably specifically comprises:

1) the appropriate pharmaceutical solutions of described mammal containing tannin is gargled, thus obtains the solution comprising described mammalian mouth inclusions;

2) the sedimentary amount of polymerism formed with gargling containing tanning solution preparation is measured;

Preferably, in step 2) front, comprise the solution of mammalian mouth inclusions described in elder generation is centrifugal; Further preferably, described centrifugal speed is 20-100g, and the time is 10-30 minute; More preferably, described centrifugal speed is 20g, and the time is 10 minutes.

Described step 2) in be measured as range estimation polymerism sedimentary how many or detect the sedimentary volume or weight of polymerism; Preferably, be measured as described in and detect the sedimentary volume of polymerism.

In addition, described method comprises the sedimentary volume of polymerism that the sedimentary volume of polymerism and detected mammal that are formed by the use detected in described sample being contained tanning solution preparation and gargling formed with gargling containing tanning solution preparation under health status further and compares, and calculates the oral inflammation index of described mammiferous personalization.

Alternatively, described method comprises the sedimentary volume of polymerism that the mammal reference person under the sedimentary volume of polymerism and health status formed by the use detected in described sample being contained tanning solution preparation and gargling formed with gargling containing tanning solution preparation further and compares, and calculates described mammiferous comparative oral inflammation index; Preferably, the sedimentary volume of polymerism that the mammal reference person under described health status is formed with gargling containing tanning solution preparation is 1 μ l.

Also on the one hand, the invention provides a kind of method of auxiliary detection mammalian mouth inflammation treatment situation, described method comprises:

Before and after mammalian mouth inflammation is treated, detect the oral inflammation degree in mammalian mouth respectively according to above-mentioned any one method, the oral inflammation degree then before and after comparison therapy;

Preferably, described oral inflammation degree is oral inflammation index;

Preferably, described oral inflammation index is personalized oral inflammation index or comparative oral inflammation index;

Preferably, described mammal is people.

On the other hand, the invention provides a kind of for detecting oral inflammation degree and the test kit of alleviation or removing oral inflammation or combination product, it is characterized in that, described test kit or combination product comprise the pharmaceutical solutions containing tannin.Preferably, described oral inflammation degree is oral inflammation index; Preferably, described oral inflammation index is personalized oral inflammation index or comparative oral inflammation index; Preferably, described mammal is people.

Described test kit or combination product comprise instrument for detecting the stomatitis speckle that brings out oral inflammation and stomatitis knot position, place in mouth and/or utensil further;

Preferably, described instrument and/or napkin bag contain: main body, cervical region and head, arrange can tie with stomatitis the function part fully contacted with stomatitis speckle at its head;

Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush and wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of pharmaceutical solutions or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis.

Described test kit or combination product comprise instrument for removing the stomatitis speckle that brings out oral inflammation and stomatitis knot and/or utensil further;

Preferably, described instrument and/or napkin bag contain: main body, cervical region and head, arrange the function part that can loosen and remove stomatitis speckle and stomatitis knot at its head;

Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of pharmaceutical solutions or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis.

Another aspect, the invention provides above-mentioned pharmaceutical solutions, test kit or combination product for the preparation of detect oral inflammation degree and alleviate or remove oral inflammation product in application.

Preferably, described oral inflammation degree is oral inflammation index;

Preferably, described oral inflammation index is personalized oral inflammation index or comparative oral inflammation index.

Also on the one hand, the invention provides the application in the product for the preparation of detection oral inflammation degree of above-mentioned pharmaceutical solutions, test kit or combination product.

Preferably, described oral inflammation degree is oral inflammation index;

On the other hand, the invention provides the application in the product for the preparation of alleviation or removing oral inflammation of above-mentioned pharmaceutical solutions, test kit or combination product.

Again on the one hand, the invention provides and a kind ofly detect mammalian mouth degree of inflammation and alleviate or remove the method for oral inflammation, it is characterized in that, described method comprises:

1) mammal as people with as described in pharmaceutical solutions gargle, allow this pharmaceutical solutions fully contact with each position in oral cavity;

2) with instrument and/or the utensil that can detect stomatitis speckle and stomatitis knot position, place in mouth of bringing out oral inflammation, each position of massaging oral, finds uncomfortable part; Uncomfortable part is stomatitis speckle and stomatitis knot position, place;

Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of pharmaceutical solutions or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis;

3) with instrument and/or the utensil that can remove stomatitis speckle and the stomatitis knot bringing out oral inflammation, the position at massage and clean stomatitis speckle and stomatitis knot place;

Preferably, described instrument and utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of solution or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis;

Preferably, step 1) in rinse time be 30 seconds; Step 2) needed for time more than 1 minute;

Preferably, described oral inflammation degree is oral inflammation index;

Preferably, described mammal is people.

On the other hand, the invention provides a kind of method alleviated or remove oral inflammation, it is characterized in that, described method comprises:

Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of solution or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis;

Preferably, described mammal is people.

On the other hand, the invention provides a kind of detection and bring out the stomatitis knot of oral inflammation and the method at position, stomatitis speckle place, described method comprises:

1) mammal such as people gargles with above-mentioned pharmaceutical solutions, allows this pharmaceutical solutions fully contact with each position in oral cavity;

Preferably, step 1) in rinse time be 30 seconds; Step 2) needed for time more than 1 minute.

Also on the one hand, the invention provides a kind of method detecting the healthy improvement situation of mammalian mouth, it is characterized in that, described method comprises:

Before and after mammalian mouth health is improved, detecting in mammalian mouth the stomatitis speckle that brings out oral inflammation and stomatitis knot position, place respectively according to above-mentioned method, there is situation in that then compares stomatitis speckle before and after improvement and stomatitis knot;

Preferably, described mammal is people.

Above-mentioned oral inflammation comprises and reacts brought out pathological changes by oral inflammation, comprises oral ulcer, periodontitis, halitosis, snoring, the sense of taste or olfactory sensation pathological changes, wrinkle and/or shape of face pathological changes.

Below detailed description of the present invention:

The present invention discloses how to remove by following research and occurs and the inflammation source embedded in oral cavity mucous membrane tissue.Remove this inflammation source, the chronic periodontitis that can heal the sick and recurrent oral ulceration.This shows, the inflammation embedding mucous membrane tissue is a kind of inducement of the oral disease relevant to inflammation.On the basis of this research, the present invention establishes the method detecting oral cavity degree of inflammation in mammalian mouth, and establishes the organic assembling by pharmaceutical solutions and Oral cleaner, thoroughly removes the method for oral inflammation.

The experimenter participating in this research suffers from recurrent oral ulceration (Figure 1A) and periodontitis, he starts to use Oral cleaner cleaning oral cavity, Oral cleaner before described Oral cleaner comprises described by patent (specifically see Chinese invention patent 2010101094421), such as: brush (knotitisremover) (Figure 1B), the tool that unhitches (knotitisopener), node-slackening brush (knotitisrelaxer) except scorching and wash scorching brush (knotitiscleanser).In cleaning course, there is uncomfortable sensation at some position of this subject oral cavity.Then to these positions, carry out carefully concentrating cleaning.

The residue turned white in cleaning process from then on position discharges, and has the appearance of bloodstain once in a while, but continuous bleeding phenomenon does not occur.Subsequently, ulcer sampling point (ulcer-likespot) there is nigh mucosa gingiva intersection mucous membrane tissue on (Fig. 1 C).Surprisingly, brown secretions discharges (Fig. 2 A) from ulcer sampling point.This secretions T ü rk ' s solution dyes, and then observes under fluorescence microscope.Obviously, containing a large amount of neutrophils (neutrophil) in this secretions, these cells all contain typical polymorphonuclear feature (Fig. 2 B, 2C).This sample is dyeed by acridine orange (Acridineorange), is proved containing neutrophils (Fig. 2 D) under fluorescence microscope.

This brown secretions seems to assemble colony containing a neutrophils with construction unit, and the neutrophils colony that these pool together is referred to as stomatitis speckle (oralinflammatoryplague).The neutrophils occurred in brown secretions is a kind of inflammatory symptom; Neutrophils release can the catabolic enzyme of damage tooth and tissue.Can discharge from a ulcer sampling point more than 10 stomatitis speckles, ulcer sampling point is cured (Fig. 1 D) subsequently.Then stomatitis speckle can not discharge from the position of suffering from ulcer sampling point again.Stomatitis speckle is present in the time marquis in ulcer sampling point, and patient can have a kind of temperature and uncomfortable sensation at this position.Once stomatitis speckle is released, patient just feels a kind of sensation as if relieved of a heavy load at once.These all show that stomatitis speckle is a kind of inflammatory reaction.

By inference, stomatitis speckle is embedded in (Fig. 3) in mucous membrane tissue.Support that the fact of this idea is, needs are taken time and stomatitis speckle discharges by strength from mucous membrane tissue.A lot of stomatitis speckle can pool together, and due to folding of mucous membrane tissue, stomatitis speckle is embedded, and forms a kind of " knot " columnar structure, is referred to as " stomatitis knot " (oralinflammatoryknotitis).Stomatitis knot can cause visible inflammatory symptom, as above-mentioned said ulcer sampling point (Fig. 3).May cause by the cell death caused by neutrophils at the visible White residule in ulcer sampling point place or precipitate.

By the process except scorching brush cleaning, find the ulcer sampling point containing more than 12 in this patient oral cavity.These ulcer sampling points are present near mucosa gingiva intersection, tongue is following, near palatine tonsil, and inner at cheek; These be all can not easily the place cleared up by current oral cavity cleaning measure.Some ulcer sampling point, than other more difficult removing, may be because caused by its position, place, size and complexity.The number of the stomatitis speckle discharged from a ulcer sampling point is different, and what have has about 10, have up to more than 100.Some stomatitis speckles are brown, and some stomatitis speckles are yellow.The volume of stomatitis speckle also changes to some extent, have at 10 microliters, have up to more than 200 microlitres.The stomatitis speckle total amount discharged from this patient is estimated more than 10 milliliters.In stomatitis speckle, the concentration estimation of neutrophils is 10 ⁷about/ml.Therefore, containing at least 10 in the oral cavity mucous membrane tissue of this patient ⁸individual neutrophils.This may be an inflammatory reaction with appreciable impact power, causes oral disease therefrom.

After 3 to 5 in 12 ulcer sampling points are eliminated, this patient notices that he does not have periodontal disease.This shows to remove the effective measures that ulcer sampling point is treatment periodontitis.Amazing, along with the further removing of ulcer sampling point, the oral ulcer also less generation of patient.After the removing of ulcer sampling point terminates, this patient also no longer suffers the puzzlement of oral ulcer.This shows that oral inflammation is the inducement causing recurrent oral ulceration.

This patient also notices, after ulcer sampling point is removed, his problem of bad breath is also eliminated.Can imagine, the microorganism be trapped in inside ulcer sampling point is the reason (Fig. 3) causing halitosis.What is interesting is, his sensory system improves, and he can smell more abnormal smells from the patient.By inference, neutrophils in the oral cavity may destroy the sensory cell in respiratory system.Therefore, remove ulcer sampling point and can treat gum disease, be also of value to healthy.

Stomatitis speckle and stomatitis knot occur in cavity interior, bring out oral inflammation reaction therefrom.This inflammatory reaction can cause the tight of oral cavity wall muscle and distortion, brings out corresponding face's position distortions therefrom herein, even brings out face wrinkles.Intraoral inflammatory reaction also can cause the tight of respiratory system muscle and distortion, affects the unobstructed of respiratory tract, causes snoring.This patient is after all stomatitis speckles removing cavity interior and stomatitis knot, and find that his facial muscle has more elasticity, face is more smooth, has also no longer snored.As can be seen here, inwall of rinsing the mouth is conducive to the health of face and respiratory tract.

These researchs show, the deficiency of current oral sanitary habit, result in food residue, cell debris (white depositions, as Fig. 1 C) and the accumulation of microorganism (problem of bad breath), these will bring out the gathering (Fig. 3) of neutrophils.But neutrophils can not remove residue that be present in hidden area, that hardened, fragment and microorganism precipitate.The neutrophils in this region is assembled colony and will be caused stomatitis speckle, release inflammatory factor and destructive material.Oral cavity mucous membrane tissue folds and the formation of more stomatitis speckles in this region, stomatitis will be caused to tie (knotitis), thus induce visible inflammatory symptom, as oral ulcer or ulcer sampling point.Along with the growth of stomatitis knot, inflammation will increase the weight of further, thus causes oral disease, as the appearance of periodontitis.Residue that be present in hidden area, that hardened, fragment and microorganism precipitate are the sources of bringing out neutrophils gathering, causing inflammatory reaction.

Through treatment after a while, the various oral problem of this experimenter, this comprises recurrent oral ulceration, periodontitis and halitosis, improves significantly.

In the process removing stomatitis knot, the present inventor is surprised to find that the sedimentary amount of the polymerism formed and oral inflammation degree have the close degree of association (Fig. 5) with the polymerism precipitate (Fig. 4) that can be formed of gargling containing the solution of tannin.Gargle with the solution containing tannin and the polymerism precipitate formed is more, oral inflammation degree is higher.The sedimentary amount of the polymerism formed also has reacted oral cleaning level; Gargle with the solution containing tannin and the polymerism precipitate formed is more, oral cleaning level is lower.

Therefore, the sedimentary amount of polymerism that the solution that can contain tannin by use collectable in oral cavity in oral inflammation degree is gargled and formed represents.The sedimentary amount of polymerism that detection is gargled with the solution containing tannin and formed contributes to judging oral cavity level of inflammation.Gargle with the solution containing tannin and the sedimentary amount of polymerism that formed by after measuring, can carry out calculating oral inflammation index.

According to the specific embodiment of the present invention, provide personalized oral inflammation index (I _i) expression way, be the sedimentary increased times of polymerism that this individuality is formed by gargling with the solution containing tannin.The computing formula of this inflammation index is as follows:

I _i＝P _t/P _h

I wherein _ifor the oral inflammation index of personalization; P _tthe solution containing tannin for the use obtained from inflammation detected object is gargled and the sedimentary amount of polymerism formed; P _hthe solution that the use obtained under the health condition of NIP for this detected object contains tannin is gargled and the sedimentary amount of polymerism formed.Detected object can be the mankind or other mammal.

In addition, present invention also offers comparative oral inflammation index (I _c) expression way, the polymerism precipitate that the solution that the use for inflammation detected object contains tannin is gargled and formed, relative to the increased times of the health reference person of NIP.The computing formula of this inflammation index is as follows:

I _c＝P _t/P _r

I wherein _cfor comparative oral inflammation index; P _tthe solution containing tannin for the use obtained from inflammation detected object is gargled and the sedimentary amount of polymerism formed; P _rthe solution containing tannin for the use of the health reference person of NIP is gargled and the sedimentary amount of polymerism formed.Detected object can be the mankind or other mammal.In an embodiment wherein, detected object is the mankind; The solution that the use of the health reference person of NIP contains tannin is gargled and the sedimentary amount (P of polymerism formed _r) be 1 μ l.

Can it is clear that, oral inflammation index is the sedimentary increased times of polymerism formed with gargling containing the solution of tannin, and this can reflect the degree of inflammation to a certain extent, helps doctor and patient to understand this oral inflammation problem further.

When detecting oral inflammation index, the sedimentary efficiency of polymerism formed with gargling containing the solution of tannin, by the impact of sampling buffer used and condition.The invention discloses sampling buffer, program and the condition that can produce concordance and repeatable result, will be explained in detail in detailed description of the invention part.

Through further investigation, present inventor disclosed oral inflammation level has closely related with the sedimentary amount of polymerism formed with gargling containing the solution of tannin, and on the basis of this discovery, the invention provides a kind of method detecting oral cavity degree of inflammation in oral cavity, and provide the Related product involved by the method.

First, the invention provides a kind of gargling for the solution of use containing tannin in mammalian mouth and form the sedimentary novel solutions of polymerism, adopt this solution as sampling solution, can gargle in oral cavity and form polymerism precipitate, and do not injure human body, can guarantee to obtain the result with concordance and repeatability;

Secondly, based on above-mentioned solution and the test kit or the combination product that comprise this solution, the invention provides the method detecting oral inflammation degree, the sedimentary amount of polymerism that the solution containing tannin by measuring use is gargled and formed assesses animal oral cavity degree of inflammation; Detecting and assessing mammalian mouth level of inflammation is quantized by calculating oral inflammation index.

The present inventor is also surprised to find that, after gargling with the solution containing tannin, the oral inflammation reaction of experimenter has obvious alleviation.Therefore, this solution product, while detection oral inflammation index, also can be alleviated or remove oral inflammation.

Because tannin has very excellent polymerism function, polymerism precipitate can be formed with some specified protein or other compound.In oral inflammation course of reaction, oral cavity may produce and can form the sedimentary specified protein of polymerism or other compound with tannin, these specified proteins or other compound also may be the important component parts of oral inflammation, and the number of its content is closely related with oral inflammation degree.Meanwhile, after tannin and these specified proteins or other compound form polymerism precipitate, also eliminate these specified proteins or the effect of other compound in oral inflammation course of reaction, thus alleviate or remove oral inflammation.

As can be seen here, gargle with the solution containing tannin, while detection oral inflammation degree, also can alleviate or remove oral inflammation.Therefore, the progress of the present invention to mouth care has important impetus.

Due to the polymerism function that it is excellent, tannin also can form polymerism precipitate with the protein or other compound bringing out oral inflammation.Some remains in intraoral protein or other compound may bring out oral inflammation; The number of its content can react oral cleaning level.Meanwhile, after tannin and these protein or other compound form polymerism precipitate, also eliminate the effect that these protein or other compound bring out oral inflammation reaction, thus cleaning of oral cavity.

As can be seen here, gargle with the solution containing tannin, while detection oral cleaning level, also can cleaning oral cavity.

The positive beneficial effect that the present invention has:

1. solution product of the present invention can be used for detecting oral inflammation degree fast, helps doctor and patient understand in time and control oral inflammation problem.Solution product of the present invention also can be used for detecting oral cleaning level fast, helps consumer understand in time and control oral cavity cleaning situation.

2. present invention also offers the method detecting oral inflammation index, this is conducive to oral health digitized.

3. solution product of the present invention is easy to use, can alleviate oral cavity sense of discomfort significantly.Frequent use effectively can clear up the soft tissue position that cavity interior is not easy to clear up, and removes the microorganism and the deposit that remain in oral cavity, makes oral cavity cleaning health, prevent and treat halitosis, make oral cavity fresh and cool, taste and smell is sensitiveer, make tongue have more elasticity and retractility, be conducive to speaking more smooth.

4. the solution product of the application of the invention and combination product, can cleaning oral cavity effectively, eliminates the source of oral inflammation: stomatitis speckle and stomatitis knot; According to the formation mechenism that stomatitis speckle and stomatitis are tied, the present invention reaches the effect thoroughly removing stomatitis speckle and stomatitis knot.

5. stomatitis speckle and stomatitis knot occur in cavity interior, bring out oral inflammation reaction therefrom.This inflammatory reaction can cause the tight of oral cavity wall muscle and distortion, brings out corresponding face's position distortions therefrom herein, even brings out face wrinkles.Intraoral inflammatory reaction also can cause the tight of respiratory system muscle and distortion, affects the unobstructed of respiratory tract, causes snoring.Remove the stomatitis speckle of cavity interior and stomatitis have be beneficial to make face and respiratory tract muscle more healthy, face is more smooth, has also no longer snored.As can be seen here, inwall of rinsing the mouth is conducive to the health of face and respiratory tract.

6. combination product of the present invention, the solution product of the application of the invention and forming a complete set of of Oral cleaner, effectively can treat patient because of stomatitis and tie oral ulcer, periodontitis and the Other diseases brought out; Form a complete set of with existing Oral cleaner, effectively can remove stomatitis speckle and stomatitis knot, all stomatitis speckles are released.Described Oral cleaner is brushed (knotitisremover), the tool that unhitches (knotitisopener), node-slackening brush (knotitisrelaxer) except scorching and washed the scorching Oral cleaner brushing (knotitiscleanser) comprising preferably described in Chinese invention patent 2010101094421, and antiinflammatory tool (knotitisresolver) (Fig. 6).

Accompanying drawing explanation

Below, describe embodiments of the invention in detail by reference to the accompanying drawings, wherein:

Fig. 1 is ulcer sampling point cleanout tool, wherein 1A: ulcer appears near palatine tonsil; 1B: one custom-designed instrument " except scorching brush (knotitisremover) ", it can be used for removing the inflammation source embedded in the oral cavity; 1C: one ulcer sampling point appears near mucosa gingiva intersection; 1D: recovery from illness after the cleaning of ulcer sampling point.

Fig. 2 is stomatitis speckle and neutrophils, wherein 2A: with except after scorching brush (knotitisremover) cleaning, from the brown secretions (shown in arrow) that a ulcer sampling point release comes; 2B: brown secretions T ü rk ' s solution-dyed, this secretions contains a large amount of neutrophils, (arrow) that food debris is seemingly relevant; 2C: the cell in secretions has typical polymorphonuclear feature; 2D: sample acridine orange (Acridineorange) dyeing, at fluorescence microscopy Microscopic observation.

Fig. 3 is the model proposed that is inflamed in oral cavity.

Fig. 4 is with the polymerism precipitate formed of gargling containing tanning solution, wherein A: from the sample of health volunteer; B: from the sample suffering from oral ulcer experimenter.

Fig. 5 detects by the sedimentary amount of polymerism formed of gargling containing tanning solution, wherein A: from the sample of health volunteer; B: from the sample of suffering from oral ulcer experimenter once in a while; C: the sample suffering from the experimenter of periodontitis and recurrent oral ulceration from.

Fig. 6 is antiinflammatory tool (knotitisresolver), comprises main body (1), cervical region (2), head (3) and strigil (4).

Detailed description of the invention

Below in conjunction with specific embodiment, and with reference to above accompanying drawing and specific experiment data, the present invention is described in further detail.Should be appreciated that these embodiments just in order to demonstrate the invention, but not limit scope of invention by any way.

Below in an example, the various process do not described in detail and method are conventional methods as known in the art.Source, the trade name of agents useful for same and be necessary to list its constituent person, all indicate when occurring first, identical reagent used if no special instructions thereafter, all identical with the content indicated first.

embodiment 1: the composition of product and preparation

Get appropriate sterile distilled water and add a suitable container, stir.Then, add ethanol, tannin, chlorhexidine gluconate or DP300, sucralose or sodium chloride respectively according to following order, and phenol red sodium.In process for preparation, keep the stirring to solution, until all the elements thing dissolves completely.

Preparation comprises the pharmaceutical solutions of following composition:

Pharmaceutical solutions 1 (in often liter of solution) is solvent with water, contains: 30 grams of ethanol, 10 grams of tannin, 0.2 gram of chlorhexidine gluconate, 0.3 gram of sucralose and 0.011 gram of phenol red sodium.

Pharmaceutical solutions 2 (in often liter of solution) is solvent with water, contains: 100 grams of ethanol, 7 grams of tannin, 0.2 gram of chlorhexidine gluconate, 0.3 gram of sucralose and 0.011 gram of phenol red sodium.

Pharmaceutical solutions 3 (in often liter of solution) is solvent with water, contains: 30 grams of ethanol, 30 grams of tannin, 0.2 gram of chlorhexidine gluconate, 0.3 gram of sucralose and 0.011 gram of phenol red sodium.

Pharmaceutical solutions 4 (in often liter of solution) is solvent with water, contains: 30 grams of ethanol, 7 grams of tannin, 1.0 grams of chlorhexidine gluconates, 0.3 gram of sucralose and 0.011 gram of phenol red sodium.

Pharmaceutical solutions 5 (in often liter of solution) is solvent with water, contains: 30 grams of ethanol, 7 grams of tannin, 0.2 gram of chlorhexidine gluconate, 0.01 gram of sucralose and 0.011 gram of phenol red sodium.

Pharmaceutical solutions 6 (in often liter of solution) is solvent with water, contains: 30 grams of ethanol, 7 grams of tannin, 0.2 gram of DP300,0.9 gram of sodium chloride and 0.011 gram of phenol red sodium.

embodiment 2: the polymerism precipitate that detection tanning solution is gargled and formed

Test the experimenter No. 2 accepting experimenter No. 1 that ulcer sampling point removes treatment and do not accept corresponding treatment in the present embodiment to gargle at the intraoral pharmaceutical solutions 1 of 9 months front and back and the polymerism precipitate that formed.

Described experimenter No. 1 is 50 years old, is attended by halitosis once in a while and oral ulcer; Experimenter No. 1 is 32 years old, suffers from oral ulcer and often halitosis occurs.

In on June 2nd, 2013 and on March 1st, 2014 to experimenter No. 1 and No. 2, have detected respectively and gargle with pharmaceutical solutions 1 and the polymerism precipitate formed, concrete detecting step is as follows:

1, gargle with the appropriate solution containing tannin, thus obtain oral cavity inclusions solution.Adopt the pharmaceutical solutions 1 of 15 milliliters, firmly gargle 30 seconds, gargle in process, allow pharmaceutical solutions fully contact each position in oral cavity.Oral cavity inclusions solution is told in a container.

2, by above-mentioned oral cavity inclusions solution under the centrifugal rotational speed of 20g, the polymerism precipitate that concentrated tanning solution is gargled and formed.

3, measure tanning solution to gargle and the sedimentary volume of polymerism that formed.Testing result sees the following form 1:

The comparison of table 1, polymerism precipitate that detection tanning solution is gargled and formed and oral inflammation index

As described in Table 1, experimenter No. 1 receives the treatment of removing ulcer sampling point, and experimenter No. 2 does not accept corresponding treatment.Experimenter No. 1, when sampling on June 2nd, 2013, suffers from halitosis and oral ulcer once in a while, and the sedimentary volume of polymerism now formed with gargling containing tanning solution is 186 μ l.Surprisingly, when same experimenter sampled (i.e. on March 1st, 2014) after 9 months, this experimenter no longer suffers from any halitosis and oral ulcer, and the sedimentary volume of polymerism now formed with gargling containing tanning solution is 1 μ l.

On the other hand, gargle from experimenter No. 2 with the solution containing tannin and the sedimentary volume of polymerism formed, in twice different sampling, almost unanimously, even if be separated by sample time 9 months.This experimenter continues often suffer from halitosis and oral ulcer.

These researchs show, the polymerism sedimentary volume energy reflection oral inflammation degree that the solution of use containing tannin is gargled and formed, and also reflects oral cleaning level.Therefore, the sedimentary volume of polymerism that the solution that use contains tannin is gargled and formed can be used for calculating oral inflammation index.

embodiment 3: the sedimentary detection of polymerism formed according to gargling with tanning solution in embodiment 2 result calculates oral inflammation index

The sedimentary testing result of polymerism that the present embodiment is formed according to gargling with tanning solution in embodiment 2 has carried out the calculating of oral inflammation index.As described in table 1, experimenter No. 1 receives ulcer sampling point and removes treatment, on June 2nd, 2013 (namely before treatment), and polymerism precipitate (P collected in this subject oral cavity _t) be: 186 μ l; In on March 1st, 2014 (namely after treatment), polymerism precipitate (P collected from the oral cavity of this experimenter _h) being: 1 μ l, that is the polymerism precipitate of this experimenter decreases 186 times.Can instead release thus, this experimenter personalized oral inflammation index (I before treatment _i) be: 186 μ l/1 μ l=186.And this experimenter is after the treatment, its personalized oral inflammation index (I _i) be: 1 μ l/1 μ l=1.

Above-mentioned experimenter, after ulcer sampling point removes treatment, can be designated as the health reference person of NIP.After treatment, the polymerism sediment volume that this person gargles with the solution containing tannin and formed can be appointed as the polymerism sediment volume (P of the health reference person of NIP _r), i.e. 1 μ l.The comparative oral inflammation index in table 1 can be extrapolated thus.

Experimenter No. 1 does not accept any treatment, and obvious change does not occur the polymerism sediment volume of this experimenter.Polymerism sediment volume (the P that this experimenter obtains under the health condition of NIP _h) be unknown.The personalized oral inflammation index (I of this experimenter _i) be also unknown.

embodiment 4: the polymerism sediment volume of different detected object and the detection of comparative oral inflammation index results contrast

The present embodiment adopts the method identical with 2 with embodiment 1 to have collected polymerism precipitate, to its comparative oral inflammation index (I from 10 different detected objects _c) detect, its result is listed in following table 2.

The oral healthy condition of table 2,10 detected objects and oral inflammation index

As described in Table 2, the polymerism precipitate (P obtained from detected object _t) and comparative oral inflammation index (I _c) numerical value and the age there is no direct relation; These numerical value can demonstrate the health problem in oral cavity." the P of 2 and No. 6 detected objects _t" and " I _c" value is the highest, the polymerism sediment volume formed is also maximum, and its oral cleaning level is also just minimum; These two detected objects are often subject to the puzzlement of halitosis and oral ulcer." the P of No. 5 detected objects _t" and " I _c" value is also very high, the polymerism sediment volume formed is also a lot, and its oral cleaning level is also just very low; This detected object is a smoker.Then, " the P of No. 7 detected objects _t" and " I _c" value is also higher, the polymerism sediment volume formed is also higher, and its oral cleaning level is also just on the low side; This detected object once suffered from carious disease." the P of other detected object _t" and " I _c" all relative lower of value, the polymerism sediment volume formed is also lower, and its oral cleaning level is also just higher; These detected objects there is no obvious oral health issue.These researchs prove again, these " P _t" and " I _c" numerical value can the level of secondary proof oral inflammation.

Because the gene in crowd are different, the polymerism sediment volume that different crowd is formed with gargling containing the solution of tannin may difference to some extent.Gargle at same individuality tanning solution and the sedimentary change of polymerism formed, more can truly reflect intraoral degree of inflammation.So, personalized oral inflammation index (I _i) reference value is had to the understanding of inflammation, but the acquisition of this index needs this individuality to carry out corresponding ulcer sampling point removes treatment.Therefore under many circumstances, the health reference person of detected object and NIP can only compare by tester, obtains its comparative oral inflammation index (I _c).In order to convenience of calculation, the polymerism sediment volume (P that the health reference person of NIP gargles with the solution containing tannin and formed _t) answer value be above-mentioned in the 1 μ l that mentions.

It should be noted that, oral inflammation index is the increased times of the polymerism sediment volume formed with gargling containing tanning solution, and this can reflect the degree of inflammation, makes doctor and detected object directly can understand the seriousness with interpretation problems.

embodiment 5

Experimenter No. 11 is 53 years old male, suffers from periodontitis, also often suffers the puzzlement of oral ulcer.This experimenter firmly gargles 30 seconds with the 15ml pharmaceutical solutions 1 in embodiment 1, gargles in process, allows pharmaceutical solutions fully contact each position in oral cavity.After spuing, containing a large amount of polymerism precipitate in its liquid of gargling.This rinse samples carried out centrifugal, find after measured, the sedimentary volume of this polymerism is 991 μ l.Its comparative oral inflammation index I _cfor: 991 μ l/1 μ l=1.

After gargling with pharmaceutical solutions 1, the canker sore pain of this experimenter is alleviated to some extent, and as can be seen here, this pharmaceutical solutions, for while detecting oral inflammation index, also can alleviate oral inflammation.

After gargling 1 minute with pharmaceutical solutions 1, this experimenter starts to use Oral cleaner cleaning oral cavity, and described Oral cleaner comprises the Oral cleaner (such as: brush (knotitisremover), the tool that unhitches (knotitisopener), the tool that unhitches (knotitisopener) except scorching and/or wash scorching brush (knotitiscleanser)) described in Chinese invention patent 2010101094421.In cleaning course, this experimenter finds that there is uncomfortable sensation at some position in his oral cavity.Then he is to these positions, carries out carefully concentrating cleaning.When oral cavity does not feel well, he gargles with this pharmaceutical solutions, finds that the discomfort in oral cavity has obvious alleviation.

Through cleaning, the residue turned white from then on position discharges, and has the appearance of bloodstain once in a while, but continuous bleeding phenomenon does not occur.Subsequently, ulcer sampling point (ulcer-likespot) occurs on the mucous membrane tissue of nigh mucosa gingiva intersection.Surprisingly, brown secretions discharges from ulcer sampling point.This secretions T ü rk ' s solution dyes, and then observes under fluorescence microscope.Obviously, containing a large amount of neutrophils (neutrophil) in this secretions, these cells all contain typical polymorphonuclear feature.This sample is dyeed by acridine orange (Acridineorange), is proved containing neutrophils under fluorescence microscope.

By the process of cleaning except scorching brush (knotitisremover), find in this patient oral cavity containing multiple ulcer sampling point.These ulcer sampling points are present near mucosa gingiva intersection, tongue is following, near palatine tonsil, and inner at cheek; These be all can not easily the place cleared up by current oral cavity cleaning measure.Some ulcer sampling point, than other more difficult removing, may be because caused by its position, place, size and complexity.The number of the stomatitis speckle discharged from a ulcer sampling point is different.Some stomatitis speckles are brown, and some stomatitis speckles are yellow.

After ulcer sampling point is eliminated, this patient notices that he does not have periodontal disease.This shows to remove the effective measures that ulcer sampling point is treatment periodontitis.Amazing, along with the further removing of ulcer sampling point, the oral ulcer also less generation of patient.After the removing of ulcer sampling point terminates, this patient also no longer suffers the puzzlement of oral ulcer.This shows that oral inflammation is the inducement causing oral cavity recurrent ulcer.

This patient also notices, after ulcer sampling point is removed, his problem of bad breath is also eliminated.Can imagine, the microorganism be trapped in inside ulcer sampling point is the reason causing halitosis.What is interesting is, his sensory system improves, and he can smell more abnormal smells from the patient.By inference, neutrophils in the oral cavity may destroy the sensory cell in respiratory system.Therefore, remove ulcer sampling point and can treat gum disease, be also of value to healthy.

Stomatitis speckle and stomatitis knot occur in cavity interior, bring out oral inflammation reaction therefrom.This inflammatory reaction can cause the tight of oral cavity wall muscle and distortion, brings out corresponding face's position distortions therefrom herein, even brings out face wrinkles.This patient is after all stomatitis speckles removing cavity interior and stomatitis knot, and find that his facial muscle has more elasticity, face is more smooth.As can be seen here, inwall of rinsing the mouth is conducive to face health.

Gargle and oral cavity cleaning through 7 months above-mentioned, every day 2-3 time, the various oral problem of this experimenter, this comprises recurrent oral ulceration, periodontitis and halitosis, improves significantly.

embodiment 6

Experimenter No. 12 is 30 years old male, often suffers from oral ulcer, and has the problems such as halitosis.This experimenter firmly gargles 30 seconds with the pharmaceutical solutions 1 in embodiment 1.Gargle in process, allow pharmaceutical solutions fully contact each position in oral cavity.After spuing, containing a large amount of polymerism precipitate in its liquid of gargling.This rinse samples carried out centrifugal, find after measured, the sedimentary volume of this polymerism is 452 μ l.Its comparative oral inflammation index I _cfor: 452 μ l/1 μ l=452.

After gargling 1 minute with pharmaceutical solutions 1, this experimenter starts with Oral cleaner, such as, antiinflammatory tool (knotitisresolver) shown in Fig. 6, cleaning oral cavity.In cleaning course, this experimenter finds that there is uncomfortable sensation at some position in his oral cavity.Then he is to these positions, carries out carefully concentrating cleaning.When oral cavity does not feel well, he gargles with this pharmaceutical solutions, finds that the discomfort in oral cavity has obvious alleviation.Gargle and oral cavity cleaning through 3 months above-mentioned, the oral problem of this experimenter, comprises recurrent oral ulceration and halitosis, is cured.

embodiment 7

Experimenter No. 13 is 23 years old women, suffers from oral ulcer.This experimenter firmly gargles 30 seconds with the pharmaceutical solutions 1 in embodiment 1.Gargle in process, allow pharmaceutical solutions fully contact each position in oral cavity.After spuing, containing polymerism precipitate in its liquid of gargling.This rinse samples carried out centrifugal, find after measured, the sedimentary volume of this polymerism is 125 μ l.Its comparative oral inflammation index I _cfor: 125 μ l/1 μ l=125.

After gargling 1 minute with pharmaceutical solutions 1, this experimenter starts to use Oral cleaner cleaning oral cavity.Gargle and oral cavity cleaning through 30 days above-mentioned, the oral ulcer of this experimenter is cured.

embodiment 8

Experimenter No. 14 is 35 years old male, suffers from oral ulcer.This experimenter firmly gargles 30 seconds with the pharmaceutical solutions 1 in embodiment 3.Gargle in process, allow pharmaceutical solutions fully contact each position in oral cavity.After spuing, containing a large amount of polymerism precipitate in its liquid of gargling.This rinse samples carried out centrifugal, find after measured, the sedimentary volume of this polymerism is 217 μ l.Its comparative oral inflammation index I _cfor: 217 μ l/1 μ l=217.

After gargling with pharmaceutical solutions 3, the canker sore pain of this experimenter is alleviated to some extent, and as can be seen here, this pharmaceutical solutions, for while detecting oral inflammation index, also can alleviate oral inflammation.

After gargling 1 five minutes with pharmaceutical solutions 3, this experimenter starts to use Oral cleaner cleaning oral cavity.Gargle and oral cavity cleaning through 34 days above-mentioned, the oral ulcer of this experimenter is cured.

embodiment 9

Experimenter No. 15 is 49 years old women, oral health.This experimenter firmly gargles 30 seconds with the pharmaceutical solutions 5 in embodiment 1.Gargle in process, allow pharmaceutical solutions fully contact each position in oral cavity.After spuing, containing polymerism precipitate in its liquid of gargling.This rinse samples carried out centrifugal, find after measured, the sedimentary volume of this polymerism is 26 μ l.Its comparative oral inflammation index I _cfor: 26 μ l/1 μ l=26.

After gargling with pharmaceutical solutions 5, the canker sore pain of this experimenter is alleviated to some extent, and as can be seen here, this pharmaceutical solutions, for while detecting oral inflammation index, also can alleviate oral inflammation.

After gargling 1 minute with pharmaceutical solutions 5, this experimenter starts to use Oral cleaner cleaning oral cavity.Gargle and oral cavity cleaning through 7 days above-mentioned, this experimenter finds that oral cavity is more pure and fresh.

embodiment 10

Experimenter No. 16 is 33 years old male, oral health.This experimenter firmly gargles 30 seconds with the pharmaceutical solutions 1 in embodiment 1.Gargle in process, allow pharmaceutical solutions fully contact each position in oral cavity.After spuing, containing polymerism precipitate in its liquid of gargling.This rinse samples carried out centrifugal, find after measured, the sedimentary volume of this polymerism is 11 μ l.Its comparative oral inflammation index I _cfor: 11 μ l/1 μ l=11.

After gargling 1 five minutes with pharmaceutical solutions 1, this experimenter starts to use Oral cleaner cleaning oral cavity.Gargle and oral cavity cleaning through 9 days above-mentioned, this experimenter finds that oral cavity is more pure and fresh.

embodiment 11

Experimenter No. 17 is 58 years old male, suffers from recurrent oral ulceration.This experimenter firmly gargles 30 seconds with the pharmaceutical solutions 1 in embodiment 1.Gargle in process, allow pharmaceutical solutions fully contact each position in oral cavity.After spuing, containing a large amount of polymerism precipitate in its liquid of gargling.This rinse samples carried out centrifugal, find after measured, the sedimentary volume of this polymerism is 351 μ l.Its comparative oral inflammation index I _cfor: 351 μ l/1 μ l=351.

After gargling 1 minute with pharmaceutical solutions 1, this experimenter starts to use Oral cleaner cleaning oral cavity.In cleaning course, this experimenter finds that there is uncomfortable sensation at some position in his oral cavity.Then he is to these positions, carries out carefully concentrating cleaning.When oral cavity does not feel well, he gargles with this pharmaceutical solutions, finds that the discomfort in oral cavity has obvious alleviation.Gargle and oral cavity cleaning through 13 days above-mentioned, the recurrent oral ulceration of this experimenter improves significantly.

embodiment 12

Experimenter No. 18 is 65 years old male, suffers from periodontitis.This experimenter firmly gargles 30 seconds with the pharmaceutical solutions 1 in embodiment 1.Gargle in process, allow pharmaceutical solutions fully contact each position in oral cavity.After spuing, containing a large amount of polymerism precipitate in its liquid of gargling.This rinse samples carried out centrifugal, find after measured, the sedimentary volume of this polymerism is 632 μ l.Its comparative oral inflammation index I _cfor: 632 μ l/1 μ l=632.

After gargling 1 minute with pharmaceutical solutions 1, this experimenter starts to use Oral cleaner cleaning oral cavity.In cleaning course, this experimenter finds that there is uncomfortable sensation at some position in his oral cavity.Then he is to these positions, carries out carefully concentrating cleaning.When oral cavity does not feel well, he gargles with this pharmaceutical solutions, finds that the discomfort in oral cavity has obvious alleviation.Gargle and oral cavity cleaning through 25 days above-mentioned, the periodontitis of suffering from of this experimenter improves significantly.

embodiment 13

Experimenter No. 19, uses the pharmaceutical solutions 1 in embodiment 1 to gargle; After half an hour, this experimenter starts to use Oral cleaner cleaning oral cavity.Time clean, these experimenters find that there is uncomfortable sensation at some position, oral cavity, and the position of these discomforts is exactly stomatitis speckle and stomatitis knot location.Through gargling and oral cavity cleaning in a few days, the inflammatory reaction at these positions obtains removing.Subsequently, after gargling with above-mentioned pharmaceutical solutions, then when carrying out oral cavity cleaning with Oral cleaner, this experimenter finds just do not have uncomfortable sensation in oral cavity.Therefore, by using above-mentioned mouthwash solution preparation and Oral cleaner, the improvement situation of oral health can just effectively be detected.

embodiment 14

With the group of 10 experimenter's compositions, the pharmaceutical solutions 1 employed in embodiment 1 is gargled, and finds that above-mentioned pharmaceutical solutions can slow down significantly or remove oral ulcer.Result shows: wherein have 2 experimenters to gargle with above-mentioned pharmaceutical solutions and once just relieve the misery of oral ulcer; There are 2 to gargle and just relieve the misery of oral ulcer for 2 times; There is 1 to gargle and just relieve the misery of oral ulcer for 4 times; Have 1 experimenter to gargle 8 times with above-mentioned pharmaceutical solutions, after each use, the symptom of oral ulcer is obtained for alleviation.Another 4 experimenters do not suffer from oral ulcer, and after gargling with above-mentioned pharmaceutical solutions, oral sensation is pure and fresh.

embodiment 15

With the group of 10 experimenter's compositions, pharmaceutical solutions 2,3,4,5 and 6 is tested, find that pharmaceutical solutions 2,3,4,5 and 6 also can slow down oral ulcer symptom effectively.

Above-mentioned embodiment shows, adopts pharmaceutical solutions of the present invention to gargle and can effectively slow down or remove the symptom of oral ulcer.

One of ordinary skill in the art should be appreciated that instance parameter disclosed in this invention can change to some extent, but do not affect inventive concept involved in the present invention, are therefore not used in the claim that restriction is involved in the present invention.

Claims

1., for detecting oral inflammation or clean-up performance, alleviation and/or removing the pharmaceutical solutions of oral inflammation and/or cleaning oral cavity, it is characterized in that, described solution comprises:

Tannin, described tannin comes from plant extract or synthetic; With

One or more are for suppressing or kill the medicine of oral microorganism, and preferably, described suppression or the medicine killing oral microorganism are: chlorhexidine gluconate hydrochlorate or DP300.

2. pharmaceutical solutions as claimed in claim 1, it is characterized in that, described pharmaceutical solutions comprises further:

Flavoring agent, for regulating the taste of described pharmaceutical solutions, described flavoring agent is preferably sucralose or sodium chloride; And/or

Coloring agent, painted for described pharmaceutical solutions, described coloring agent is preferably phenol red sodium or beet red.

3. pharmaceutical solutions as claimed in claim 1 or 2, it is characterized in that, described tannin comes from plant extract; Preferably, described plant be selected from tea, Fructus Lycopersici esculenti, Fructus Mali pumilae, Lee, Fructus Vitis viniferae or other contain trees or the fruit of tannin.

4. the pharmaceutical solutions according to any one of claim 1-3, is characterized in that, described pharmaceutical solutions is in often liter of solution, comprise: 1-300 gram of ethanol, 1-100 gram of tannin, 0.01-1.00 gram of chlorhexidine gluconate, 0.01-1.00 gram of sucralose and 0.01-0.02 gram of phenol red sodium;

Preferably, described pharmaceutical solutions, in often liter of solution, comprises: 30-100 gram of ethanol, 7-30 gram of tannin, 0.1-0.2 gram of chlorhexidine gluconate, 0.01-0.3 gram of sucralose and 0.011 gram of phenol red sodium.

5. the pharmaceutical solutions according to any one of claim 1-6, is characterized in that, described pharmaceutical solutions is aqueous solution or glucose solution; Preferably, the concentration of glucose of described glucose solution is 1-150 grams per liter.

6. one kind for detecting mammalian mouth degree of inflammation or clean-up performance, alleviation or removing the combination product of oral inflammation and/or cleaning oral cavity, described mammal is preferably people, described combination product is preferably test kit, it is characterized in that, described combination product comprises:

Pharmaceutical solutions according to any one of claim 1-5; With

7. combination product as claimed in claim 6, is characterized in that, described combination product comprises instrument for removing stomatitis speckle and the stomatitis knot bringing out oral inflammation and/or utensil further;

8. tannin solution is for the preparation of 1) detect oral inflammation degree, 2) alleviate or remove oral inflammation, 3) detect oral cleaning level and/or 4) application in the product of cleaning oral cavity.

9. the pharmaceutical solutions according to any one of claim 1-5 or the combination product as described in claim 6 or 7 are for the preparation of 1) detect oral inflammation degree, 2) alleviate or remove oral inflammation, 3) detect oral cleaning level and/or 4) application in the product of cleaning oral cavity.

10. the pharmaceutical solutions according to any one of claim 1-5 or the combination product as described in claim 6 or 7 or apply as claimed in claim 8 or 9, described oral inflammation comprises and reacts brought out pathological changes by oral inflammation, preferably from oral ulcer, periodontitis, halitosis, snoring, the sense of taste or olfactory sensation pathological changes, wrinkle and/or shape of face pathological changes.