CN103385802B - Alleviate or remove the solution product of stomatitis knot and stomatitis speckle, combination product and application thereof - Google Patents
Alleviate or remove the solution product of stomatitis knot and stomatitis speckle, combination product and application thereof Download PDFInfo
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Abstract
The invention provides a kind of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, and its inflammatory reaction roughly the same or tied by stomatitis and the sense of taste that stomatitis speckle brings out, olfactory sensation and/or shape of face pathological changes solution product, described solution product is collutory or the clear scorching water for cleaning a wound.In addition, present invention also offers the combination product comprising above-mentioned solution product and application thereof.Solution product of the present invention is easy to use, often uses the soft tissue position effectively can cleared up cavity interior and be not easy to clear up, removes the microorganism and the deposit that remain in oral cavity, make oral cavity cleaning health, prevent and treat halitosis.The solution product of the application of the invention and combination product, can eliminate the source of oral inflammation: stomatitis speckle and stomatitis knot effectively; Effectively can treat patient because of stomatitis and tie oral ulcer, periodontitis and the Other diseases brought out.
Description
Technical field
The invention belongs to field of oral care, relate to and a kind ofly alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, and its inflammatory reaction roughly the same or tied by stomatitis and the sense of taste that stomatitis speckle brings out, the solution product of olfactory sensation and shape of face pathological changes, combination product and application thereof.
Background technology
Overwhelming majority people brushes teeth twice every day sooner or later, has many people also to clean one's teeth on schedule, but a lot of people also has oral problem, as oral ulcer, inflammation, periodontitis and halitosis.According to statistical analysis, the crowd of more than 90% suffers from oral disease in various degree, as problems such as periodontitis, dental caries, oral ulcer and halitosiss.
Oral ulcer, is commonly called as oral cavity and gets angry, directly affect work efficiency.One to work strain and busy time, will BAIPAO be played in the oral cavity of a lot of people, allow people's hurt like hell.This both affected task efficiency, perplexed again the mood of people.Recurrent oral ulceration annoyings a lot of crowd, its unknown etiology as yet.
Oral inflammation affects the curative effect of multiple oral medical measure (as plantation, correction).The patient that oral inflammation is heavier, often after plantation or correction, its medical effect is not ideal enough, even causes malpractice.Lowering and controlling oral inflammation is the prerequisite of carrying out the medical measures such as plantation and correction.
Periodontitis not only can cause loosening and coming off of tooth, and affects whole healthy.Periodontitis and major disease (as heart disease, diabetes and old apoplexy) closely related, be also considered to after cancer and heart disease, threaten the third-largest killer of human health.The order of severity of periodontitis in different patient differs widely; Effect after periodontal scaling is also limited by the host immunity function that can not control.
Halitosis is a problem making people very awkward.Pay attention to the modern society of personal image at this, halitosis directly affects the work relationship of getting along with other people, also affects self-confidence and the image of individual.Everyone does not wish have any mishap and defect on this problem.Halitosis often annoyings a lot of people on the hop.
These different oral problem have a common feature: they have a kind of be difficult to predict uncertainty.This illustrates that there is a kind of X factor in oral cavity is affecting oral health.
Up-to-date research finds: also exist in oral cavity a kind of before not the inflammation understood by the mankind originate; This newfound oral inflammation is originated the multiple oral problem directly affected in oral cavity.Source, this new oral cavity is referred to as " stomatitis speckle " (OralInflammatoryPlague) and " stomatitis knot " (OralInflammatoryKnotitis) (specifically see Chinese invention patent application CN201010109442.1).
People often only clean tooth.If other position is not cleaned in the oral cavity accounting for greater part, food debris and bacterial adsorption can be caused, remain in and be not easy by the oral soft tissue that cleans, thus form the source of oral inflammation.Inflammation is the incitant of oral ulcer, periodontitis and other oral disease.
The oral inflammation source of this new cognition occurs in the soft tissue position that cavity interior is not easy cleaning, mainly appear at the position, oral cavity that existing oral appliance can not effectively be cleared up, as the intersection of (1) gingiva root and oral cavity wall, the i.e. close region of " mucosa gum circle " (mucogingivaljunction), (2) oral cavity wall, (3) root of the tongue inwall, (4) tongue bottom, and (5) oral cavity and tongue intersection.
Because above-mentioned position can not be cleared up effectively, different materials deposits at this, and this comprises antibacterial and food waste.These deposits can bring out the immunocyte of human body, particularly neutrophils (Neutrophil), assemble this place in a large number.But these immunocytes are cannot remove that these have hardened sedimental.These immunocytes discharge multiple catabolic enzyme and toxicant (Milleretal1984; Kantarcietal2003), and immune response signal, thus bring out inflammatory reaction (Wrightetal1986; Cassatella2003; Serhan & Savill2005), thus form " stomatitis speckle " (OralInflammatoryPlague).
The existence of stomatitis speckle will bring out the Soft Tissue Deformation of periphery, is wrapped in wherein by stomatitis speckle.Because region of interest can not effectively be cleared up, new precipitate continues deposition at this, thus brings out the formation of more stomatitis speckle.Soft tissue around also will be out of shape, and be encased by these stomatitis speckles, a large amount of gatherings of stomatitis speckle, will be formed " stomatitis knot " (OralInflammatoryKnotitis).
Summary of the invention
In order to successfully manage stomatitis speckle and stomatitis knot, the invention provides and alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, and its inflammatory reaction roughly the same or tied by stomatitis and the sense of taste that stomatitis speckle brings out, the Related product of olfactory sensation and shape of face pathological changes and application thereof.
For contributing to understanding the present invention, define some terms below.Term defined herein has the implication that those of ordinary skill in the related art of the present invention understand usually.
Unless otherwise indicated, term used herein " stomatitis speckle " (OralInflammatoryPlague) refers to and is present in gathering colony in oral soft tissue, that bring out the immunocyte of oral inflammation reaction.
Unless otherwise indicated, term used herein " stomatitis knot " (OralInflammatoryKnotitis) refers to and is present in gathering colony in oral soft tissue, that bring out oral inflammation reaction, numerous stomatitis speckle.
Stomatitis speckle and stomatitis knot are the sources of oral inflammation.Inflammation is the incitant of oral ulcer, periodontitis and other oral disease.
Unless otherwise indicated, term used herein " clear scorching water " (Inflammation-removingsolution) refer to alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, and its inflammatory reaction roughly the same or tied by stomatitis and the sense of taste that stomatitis speckle brings out, olfactory sensation and shape of face pathological changes solution product; Described inflammation comprises the inflammatory reaction of oral cavity or other position of health or organ.
Stomatitis speckle and stomatitis knot occur in cavity interior, bring out oral inflammation reaction therefrom.Also can occur in other position or the organ of health with its inflammatory reaction roughly the same, after such as skin damage, if do not obtained medical treatment in time, likely can cause infection, cause inflammatory reaction, the similar ulcer of its symptom.
Unless otherwise indicated, term used herein " with its inflammatory reaction roughly the same " refers to the inflammatory reaction occurring in other position beyond oral cavity or organ, and its genesis mechanism is analogous to be tied by stomatitis speckle and stomatitis brings out oral inflammation and react; Its inflammatory reaction be alleviated or be removed to clear scorching water provided in this article can.
In order to solve the problems of the technologies described above, an object of the present invention is to provide a kind of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, and its inflammatory reaction roughly the same or tied by stomatitis and the sense of taste that stomatitis speckle brings out, olfactory sensation and/or shape of face pathological changes solution product.
Another object of the present invention be to provide a kind of for alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, and its inflammatory reaction roughly the same or tied by stomatitis and the sense of taste that stomatitis speckle brings out, olfactory sensation and/or shape of face pathological changes combination product.
Another object of the present invention be to provide above-mentioned solution product or above-mentioned combination product for the preparation of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, and its inflammatory reaction roughly the same or tied by stomatitis and the sense of taste that stomatitis speckle brings out, olfactory sensation and/or shape of face pathological changes product in application.
Another object of the present invention be to provide a kind of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, and its inflammatory reaction roughly the same or tied by stomatitis and the sense of taste that stomatitis speckle brings out, olfactory sensation and/or shape of face pathological changes method.
Another object of the present invention is to provide a kind of method detecting stomatitis knot and position, stomatitis speckle place.
An also object of the present invention is to provide a kind of method detecting the healthy improvement situation of mammalian mouth.
The object of the invention is to be achieved through the following technical solutions:
On the one hand, the invention provides a kind of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, and its inflammatory reaction roughly the same or tied by stomatitis and the sense of taste that stomatitis speckle brings out, olfactory sensation and/or shape of face pathological changes solution product; Described solution product is preferably collutory or the clear scorching water for cleaning a wound, and described solution product comprises for stomatitis speckle in soft and delivering oral and stomatitis knot or alleviates or the organic solvent of eliminate the inflammation reaction, salt and acid.
Preferably, described organic solvent be selected from ethanol and other effective and safe have in agent solvent one or more, described salt be selected from the salt of sodium chloride, potassium chloride and other effective and safe one or more, and described acid is selected from one or more in the acid of ascorbic acid, citric acid and other effective and safe.
Preferably, described solution product comprises the compound for suppressing or kill oral microorganism further.
Preferably, described suppression or the compound that kills oral microorganism are: hibitane glucose.
Preferably, described solution product comprises the compound of the taste for regulating this solution product further.
Preferably, described for regulating the compound of the taste of this solution product to be: sucralose.
Preferably, described solution product comprises further for painted compound.
Preferably, describedly for painted compound be: phenol red sodium.
Preferably, described solution product, in often liter of solution, comprises: 1-300 gram of ethanol, 1-30 gram of sodium chloride, 1-30 gram of ascorbic acid, 0.01-1.00 gram of hibitane glucose, 0.01-1.00 gram of sucralose and 0.01-0.02 gram of phenol red sodium.
Preferably, described solution product, in often liter of solution, comprises 100 grams of ethanol, 9 grams of sodium chloride, 10 grams of ascorbic acid, 0.2 gram of hibitane glucose, 0.3 gram of sucralose and 0.011 gram of phenol red sodium.
Preferably, described solution product, in often liter of solution, comprises 300 grams of ethanol, 1 gram of sodium chloride, 30 grams of ascorbic acid, 1.0 grams of hibitane glucoses, 0.01 gram of sucralose and 0.011 gram of phenol red sodium.
Preferably, described solution product, in often liter of solution, comprises 1 gram of ethanol, 30 grams of sodium chloride, 1 gram of ascorbic acid, 0.01 gram of hibitane glucose, 1.0 grams of sucralose and 0.011 gram of phenol red sodium.
Preferably, described solution product, in often liter of solution, comprises 100 grams of ethanol, 9 grams of sodium chloride, 10 grams of citric acids, 0.2 gram of hibitane glucose, 0.3 gram of sucralose and 0.011 gram of phenol red sodium.
Preferably, described solution product, in often liter of solution, comprises 100 grams of ethanol, 9 grams of potassium chloride, 10 grams of ascorbic acid, 0.2 gram of hibitane glucose, 0.3 gram of sucralose and 0.011 gram of phenol red sodium.
Preferably, described solution product is aqueous solution or glucose solution.
Preferably, the concentration of glucose in described glucose solution is 0.1-15%w/v.
On the other hand, the invention provides a kind of for alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, and its inflammatory reaction roughly the same or tied by stomatitis and the sense of taste that stomatitis speckle brings out, olfactory sensation and/or shape of face pathological changes combination product, described combination product comprises above-mentioned solution product.
Preferably, described combination product comprises further for detecting stomatitis speckle and stomatitis the knot instrument at position, place and/or utensil in mouth.
Preferably, described instrument and/or napkin bag contain: main body, cervical region and head, arrange can tie with stomatitis the function part fully contacted with stomatitis speckle at its head.
Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of solution or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis.
Preferably, described combination product comprise further for remove stomatitis speckle and stomatitis knot instrument and/or utensil.
Preferably, described instrument and/or napkin bag contain: main body, cervical region and head, arrange the function part that can loosen and remove stomatitis speckle and stomatitis knot at its head.
Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of solution or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis.
Another aspect, the invention provides above-mentioned solution product or above-mentioned combination product for the preparation of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, and its inflammatory reaction roughly the same or tied by stomatitis and the sense of taste that stomatitis speckle brings out, olfactory sensation and/or shape of face pathological changes product in application.
Again on the one hand, the invention provides a kind of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, and its inflammatory reaction roughly the same or tied by stomatitis and the sense of taste that stomatitis speckle brings out, olfactory sensation and/or shape of face pathological changes method, described method comprises:
1) mammal such as people gargles by solution product above-mentioned in right amount, allows this solution product fully contact with each position in oral cavity;
2) active ingredient of solution product is allowed fully to soften and soft stomatitis speckle and stomatitis knot;
3) with instrument and/or the utensil that can detect stomatitis speckle and stomatitis knot position, place in mouth, each position of massaging oral, finds uncomfortable part; Uncomfortable part is stomatitis speckle and stomatitis knot position, place;
Preferably, described instrument and/or napkin bag contain: main body, cervical region and head, arrange can tie with stomatitis the function part fully contacted with stomatitis speckle at its head;
Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of solution or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis;
4) with instrument and/or the utensil that can remove stomatitis speckle and stomatitis knot, the position at massage and clean stomatitis speckle and stomatitis knot place;
Preferably, described instrument and/or napkin bag contain: main body, cervical region and head, arrange the function part that can loosen and remove stomatitis speckle and stomatitis knot at its head;
Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of solution or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis.
Preferably, step 1) in rinse time be 30 seconds; Step 2) needed for time more than 5 minutes.
On the other hand, the invention provides a kind of method detecting stomatitis knot and position, stomatitis speckle place, described method comprises:
1) mammal such as people gargles by solution product above-mentioned in right amount, allows this solution product fully contact with each position in oral cavity;
2) active ingredient of solution product is allowed fully to soften and soft stomatitis speckle and stomatitis knot;
3) with instrument and/or the utensil that can detect stomatitis speckle and stomatitis knot position, place in mouth, each position of massaging oral, finds uncomfortable part; Uncomfortable part is stomatitis speckle and stomatitis knot position, place;
Preferably, described instrument and/or napkin bag contain: main body, cervical region and head, arrange can tie with stomatitis the function part fully contacted with stomatitis speckle at its head;
Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of solution or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis;
Preferably, step 1) in rinse time be 30 seconds; Step 2) needed for time more than 5 minutes.
Also on the one hand, the invention provides a kind of method detecting the healthy improvement situation of mammalian mouth, described method comprises:
Before and after improving mammalian mouth health, detecting stomatitis speckle and stomatitis knot position, place in mammalian mouth respectively according to said method, there is situation in that then compares stomatitis speckle before and after improvement and stomatitis knot.
Preferably, described mammal is people.
The present invention discloses how to remove by following research and occurs and the inflammation source embedded in oral cavity mucous membrane tissue.Remove this inflammation source, the chronic periodontitis that can heal the sick and regular ulcer.This shows, the inflammation embedding mucous membrane tissue is a kind of inducement of the oral disease relevant to inflammation.On the basis of this research, the present invention sets up the organic assembling by solution product and Oral cleaner, thoroughly removes the method for stomatitis speckle and stomatitis knot.
The experimenter suffering from oral ulcer, periodontitis, inflammation and/or the halitosis that stomatitis is tied and stomatitis speckle brings out firmly gargles 30 seconds by solution product of the present invention, gargles in process, allows solution product fully contact each position in oral cavity.
After five minutes, this experimenter starts to use Oral cleaner cleaning oral cavity, the Oral cleaner (such as: remove scorching brush, the tool that unhitches, node-slackening brush and wash scorching brush) before described Oral cleaner comprises described by patent (specifically see Chinese invention patent application CN201010109442.1).In cleaning course, there is uncomfortable sensation at some position of this subject oral cavity.Then to these positions, carry out carefully concentrating cleaning.When oral cavity does not feel well, gargle by this solution product, find that the discomfort in oral cavity has obvious alleviation.
The residue turned white in cleaning process from then on position discharges, and has the appearance of bloodstain once in a while, but continuous bleeding phenomenon does not occur.Subsequently, ulcer sampling point (ulcer-likespot) occurs on the mucous membrane tissue of nigh mucosa gingiva intersection.Surprisingly, brown secretions discharges from ulcer sampling point.This secretions T ü rk ' s solution dyes, and then observes under fluorescence microscope.Obviously, containing a large amount of neutrophils (neutrophil) in this secretions, these cells all contain typical polymorphonuclear feature.This sample is dyeed by acridine orange (Acridineorange), is proved containing neutrophils under fluorescence microscope.
This brown secretions seems to assemble colony containing a neutrophils with construction unit, and the neutrophils colony that these pool together is referred to as stomatitis speckle (oralinflammatoryplague).The neutrophils occurred in brown secretions is a kind of inflammatory symptom; Neutrophils release can the catabolic enzyme of damage tooth and tissue.Can discharge multiple stomatitis speckle from a ulcer sampling point, ulcer sampling point is cured subsequently.Then stomatitis speckle can not discharge from the position of suffering from ulcer sampling point again.Stomatitis speckle is present in the time marquis in ulcer sampling point, and patient can have a kind of temperature and uncomfortable sensation at this position.Once stomatitis speckle is released, patient just feels a kind of sensation as if relieved of a heavy load at once.These all show that stomatitis speckle is a kind of inflammatory reaction.
By inference, stomatitis speckle is embedded in mucous membrane tissue.Support that the fact of this idea is, needs are taken time and stomatitis speckle discharges by strength from mucous membrane tissue.A lot of stomatitis speckle can pool together, and due to folding of mucous membrane tissue, stomatitis speckle is embedded, and forms a kind of " knot " columnar structure, is referred to as " stomatitis knot " (oralinflammatoryknotitis).Stomatitis knot can cause visible inflammatory symptom, as above-mentioned said ulcer sampling point.May cause by the cell death caused by neutrophils at the visible White residule in ulcer sampling point place or precipitate.
By the process except scorching brush cleaning, find in this patient oral cavity containing multiple ulcer sampling point.These ulcer sampling points are present near mucosa gingiva intersection, tongue is following, near palatine tonsil, and inner at cheek; These be all can not easily the place cleared up by current oral cavity cleaning measure.Some ulcer sampling point, than other more difficult removing, may be because caused by its position, place, size and complexity.The number of the stomatitis speckle discharged from a ulcer sampling point is different.Some stomatitis speckles are brown, and some stomatitis speckles are yellow.
After ulcer sampling point is eliminated, this patient notices that he does not have periodontal disease.This shows to remove the effective measures that ulcer sampling point is treatment periodontitis.Amazing, along with the further removing of ulcer sampling point, the oral ulcer also less generation of patient.After the removing of ulcer sampling point terminates, this patient also no longer suffers the puzzlement of oral ulcer.This shows that oral inflammation is the inducement causing oral cavity recurrent ulcer.
This patient also notices, after ulcer sampling point is removed, his problem of bad breath is also eliminated.Can imagine, the microorganism be trapped in inside ulcer sampling point is the reason (Fig. 1) causing halitosis.What is interesting is, his sensory system improves, and he can smell more abnormal smells from the patient.By inference, neutrophils in the oral cavity may destroy the sensory cell in respiratory system.Therefore, remove ulcer sampling point and can treat gum disease, be also of value to healthy.
Stomatitis speckle and stomatitis knot occur in cavity interior, bring out oral inflammation reaction therefrom.This inflammatory reaction can cause the tight of oral cavity wall muscle and distortion, brings out corresponding face's position distortions therefrom herein, even brings out face wrinkles.This patient is after all stomatitis speckles removing cavity interior and stomatitis knot, and find that his facial muscle has more elasticity, face is more smooth.As can be seen here, inwall of rinsing the mouth is conducive to face health.
These researchs show, the deficiency of current oral sanitary habit, result in food residue, the accumulation of cell debris (white depositions) and microorganism (problem of bad breath), and these will bring out the gathering (Fig. 1) of neutrophils.But neutrophils can not remove residue that be present in hidden area, that hardened, fragment and microorganism precipitate.The neutrophils in this region is assembled colony and will be caused stomatitis speckle, release inflammatory factor and destructive material.Oral cavity mucous membrane tissue folds and the formation of more stomatitis speckles in this region, stomatitis will be caused to tie (knotitis), thus induce visible inflammatory symptom, as oral ulcer or ulcer sampling point.Along with the growth of stomatitis knot, inflammation will increase the weight of further, thus causes oral disease, as the appearance of periodontitis.Residue that be present in hidden area, that hardened, fragment and microorganism precipitate are the sources of bringing out neutrophils gathering, causing inflammatory reaction.
Through treatment after a while, the various oral problem of this experimenter, this comprises recurrent oral ulceration, periodontitis and halitosis, improves significantly.
The positive beneficial effect that the present invention has:
1. solution product of the present invention is easy to use, often uses the soft tissue position effectively can cleared up cavity interior and be not easy to clear up, removes the microorganism and the deposit that remain in oral cavity, make oral cavity cleaning health, prevent and treat halitosis; Can alleviate oral cavity sense of discomfort significantly, make oral cavity fresh and cool, taste and smell is sensitiveer, makes tongue have more elasticity and retractility, is conducive to speaking more smooth.
2. stomatitis speckle and stomatitis knot occur in cavity interior, bring out oral inflammation reaction therefrom.This inflammatory reaction can cause the tight of oral cavity wall muscle and distortion, brings out corresponding face's position distortions therefrom herein, even brings out face wrinkles.The stomatitis speckle of removing cavity interior and stomatitis have to be beneficial to and make facial muscle have more elasticity, and face is more smooth.As can be seen here, inwall of rinsing the mouth is conducive to face health.
3. other position of health or organ often injured because of a variety of causes.After such as skin damage, if can not obtain medical treatment in time, just likely cause infection, cause inflammatory reaction.This inflammatory reaction roughly the same stomatitis speckle and stomatitis may tie the oral inflammation reaction brought out; Use clear scorching water of the present invention can slow down inflammation and the pain of skin wound.Therefore, clear scorching water of the present invention is used to be conducive to the healing of wound.
4. combination product of the present invention, the solution product of the application of the invention and forming a complete set of of Oral cleaner, effectively can treat patient because of stomatitis and tie oral ulcer, periodontitis and the Other diseases brought out; Form a complete set of with existing Oral cleaner, effectively can remove stomatitis speckle and stomatitis knot, all stomatitis speckles are released.Described Oral cleaner removes scorching brush, the tool that unhitches, node-slackening brush and washes the Oral cleaner of scorching brush comprising preferably described in Chinese invention patent application CN201010109442.1.
5. the solution product of the application of the invention and combination product, can eliminate the source of oral inflammation: stomatitis speckle and stomatitis knot effectively; According to the formation mechenism that stomatitis speckle and stomatitis are tied, the present invention reaches the effect thoroughly removing stomatitis speckle and stomatitis knot.
Accompanying drawing explanation
Below, describe embodiment of the present invention in detail by reference to the accompanying drawings, wherein:
Fig. 1 is the model proposed that is inflamed in oral cavity.
Fig. 2 is the neutrophils in stomatitis speckle, wherein 2A: with T ü rk ' s solution-dyed, display stomatitis speckle contains a large amount of neutrophils; Its cell has typical polymorphonuclear feature; 2B: sample acridine orange (Acridineorange) dyeing, at fluorescence microscopy Microscopic observation.
Fig. 3 is antiinflammatory tool, comprises main body (1), cervical region (2), head (3) and strigil (4).
Detailed description of the invention
Below in conjunction with specific embodiment, and comparable data describes in further detail the present invention.Should be understood that these embodiments just in order to demonstrate the invention, but not limit scope of invention by any way.
Below in an example, the various process do not described in detail and method are conventional methods as known in the art.
embodiment 1
Conventionally preparation comprises the solution product of following composition:
Solution product 1 (in often liter of solution) contains: 100 grams of ethanol, 9 grams of sodium chloride, 10 grams of ascorbic acid, 0.2 gram of hibitane glucose, and 0.3 gram of sucralose and 0.011 gram of phenol red sodium, all the other are water.
Solution product 2 (in often liter of solution) contains: 300 grams of ethanol, 1 gram of sodium chloride, 30 grams of ascorbic acid, 1.0 grams of hibitane glucoses, and 0.01 gram of sucralose and 0.011 gram of phenol red sodium, all the other are water.
Solution product 3 (in often liter of solution) contains: 1 gram of ethanol, 30 grams of sodium chloride, 1 gram of ascorbic acid, 0.01 gram of hibitane glucose, and 1.0 grams of sucralose and 0.011 gram of phenol red sodium, all the other are water.
Solution product 4 (in often liter of solution) contains: 100 grams of ethanol, 9 grams of sodium chloride, 10 grams of citric acids, 0.2 gram of hibitane glucose, and 0.3 gram of sucralose and 0.011 gram of phenol red sodium, all the other are water.
Solution product 5 (in often liter of solution) contains: 100 grams of ethanol, 9 grams of potassium chloride, 10 grams of ascorbic acid, 0.2 gram of hibitane glucose, and 0.3 gram of sucralose and 0.011 gram of phenol red sodium, all the other are water.
embodiment 2
Experimenter No. 1 is 51 years old male, suffers from the periodontitis of 17 years, also often suffers the puzzlement of oral ulcer.This experimenter firmly gargles 30 seconds by the solution product 1 in embodiment 1, gargles in process, allows solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use Oral cleaner cleaning oral cavity, and described Oral cleaner comprises the Oral cleaner (such as: remove scorching brush, the tool that unhitches, node-slackening brush and/or wash scorching brush) described in Chinese invention patent application CN201010109442.1.In cleaning course, this experimenter finds that there is uncomfortable sensation at some position in his oral cavity.Then he is to these positions, carries out carefully concentrating cleaning.When oral cavity does not feel well, he gargles by this solution product, finds that the discomfort in oral cavity has obvious alleviation.
Through cleaning, the residue turned white from then on position discharges, and has the appearance of bloodstain once in a while, but continuous bleeding phenomenon does not occur.Subsequently, ulcer sampling point (ulcer-likespot) occurs on the mucous membrane tissue of nigh mucosa gingiva intersection.Surprisingly, brown secretions discharges from ulcer sampling point.This secretions T ü rk ' s solution dyes, and then observes under fluorescence microscope.Obviously, containing a large amount of neutrophils (neutrophil) in this secretions, these cells all contain typical polymorphonuclear feature.This sample is dyeed by acridine orange (Acridineorange), is proved containing neutrophils (Fig. 2) under fluorescence microscope.
By the process except scorching brush cleaning, find in this patient oral cavity containing multiple ulcer sampling point.These ulcer sampling points are present near mucosa gingiva intersection, tongue is following, near palatine tonsil, and inner at cheek; These be all can not easily the place cleared up by current oral cavity cleaning measure.Some ulcer sampling point, than other more difficult removing, may be because caused by its position, place, size and complexity.The number of the stomatitis speckle discharged from a ulcer sampling point is different.Some stomatitis speckles are brown, and some stomatitis speckles are yellow.
After ulcer sampling point is eliminated, this patient notices that he does not have periodontal disease.This shows to remove the effective measures that ulcer sampling point is treatment periodontitis.Amazing, along with the further removing of ulcer sampling point, the oral ulcer also less generation of patient.After the removing of ulcer sampling point terminates, this patient also no longer suffers the puzzlement of oral ulcer.This shows that oral inflammation is the inducement causing oral cavity recurrent ulcer.
This patient also notices, after ulcer sampling point is removed, his problem of bad breath is also eliminated.Can imagine, the microorganism be trapped in inside ulcer sampling point is the reason (Fig. 1) causing halitosis.What is interesting is, his sensory system improves, and he can smell more abnormal smells from the patient.By inference, neutrophils in the oral cavity may destroy the sensory cell in respiratory system.Therefore, remove ulcer sampling point and can treat gum disease, be also of value to healthy.
Stomatitis speckle and stomatitis knot occur in cavity interior, bring out oral inflammation reaction therefrom.This inflammatory reaction can cause the tight of oral cavity wall muscle and distortion, brings out corresponding face's position distortions therefrom herein, even brings out face wrinkles.This patient is after all stomatitis speckles removing cavity interior and stomatitis knot, and find that his facial muscle has more elasticity, face is more smooth.As can be seen here, inwall of rinsing the mouth is conducive to face health.
Gargle and oral cavity cleaning through 25 days above-mentioned, every day 2-3 time, the various oral problem of this experimenter, this comprises recurrent oral ulceration, periodontitis and halitosis, improves significantly.
embodiment 3
Experimenter No. 2 is 30 years old male, often suffers from oral ulcer, and has the problems such as halitosis.This experimenter firmly gargles 30 seconds by the solution product 1 in embodiment 1.Gargle in process, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts with Oral cleaner, such as, antiinflammatory tool shown in Fig. 3, cleaning oral cavity.In cleaning course, this experimenter finds that there is uncomfortable sensation at some position in his oral cavity.Then he is to these positions, carries out carefully concentrating cleaning.When oral cavity does not feel well, he gargles by this solution product, finds that the discomfort in oral cavity has obvious alleviation.Gargle and oral cavity cleaning through 10 days above-mentioned, the oral problem of this experimenter, comprises recurrent oral ulceration and halitosis, is cured.
embodiment 4
Experimenter No. 3 is 21 years old women, suffers from oral ulcer.This experimenter firmly gargles 30 seconds by the solution product 1 in embodiment 1.Gargle in process, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use Oral cleaner cleaning oral cavity.Gargle and oral cavity cleaning through 2 days above-mentioned, the oral ulcer of this experimenter is cured.
embodiment 5
Experimenter No. 4 is 35 years old male, suffers from oral ulcer.This experimenter firmly gargles 30 seconds by the solution product 1 in embodiment 1.Gargle in process, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use Oral cleaner cleaning oral cavity.Gargle and oral cavity cleaning through 3 days above-mentioned, the oral ulcer of this experimenter is cured.
embodiment 6
Experimenter No. 5 is 62 years old male, suffers from periodontitis.This experimenter firmly gargles 30 seconds by the solution product 1 in embodiment 1.Gargle in process, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use Oral cleaner cleaning oral cavity.In cleaning course, this experimenter finds that there is uncomfortable sensation at some position in his oral cavity.Then he is to these positions, carries out carefully concentrating cleaning.When oral cavity does not feel well, he gargles by this solution product, finds that the discomfort in oral cavity has obvious alleviation.Gargle and oral cavity cleaning through 10 days above-mentioned, the periodontitis of suffering from of this experimenter improves significantly.
embodiment 7
Experimenter No. 6 is 61 years old male, suffers from recurrent oral ulceration.This experimenter firmly gargles 30 seconds by the solution product 1 in embodiment 1.Gargle in process, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use Oral cleaner cleaning oral cavity.In cleaning course, this experimenter finds that there is uncomfortable sensation at some position in his oral cavity.Then he is to these positions, carries out carefully concentrating cleaning.When oral cavity does not feel well, he gargles by this solution product, finds that the discomfort in oral cavity has obvious alleviation.Gargle and oral cavity cleaning through 6 days above-mentioned, the recurrent oral ulceration of this experimenter improves significantly.
embodiment 8
Experimenter No. 7 is 34 years old women, has slight oral inflammation.This experimenter firmly gargles 30 seconds by the solution product 1 in embodiment 1.Gargle in process, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use Oral cleaner cleaning oral cavity.In cleaning course, this experimenter finds that there is uncomfortable sensation at some position in her oral cavity.Then she is to these positions, carries out carefully concentrating cleaning.When oral cavity does not feel well, she gargles by this solution product, finds that the discomfort in oral cavity has obvious alleviation.Gargle and oral cavity cleaning through 6 days above-mentioned, the slight oral inflammation of this experimenter is cured.
embodiment 9
Experimenter No. 8 is 50 years old women, oral health.This experimenter firmly gargles 30 seconds by the solution product 1 in embodiment 1.Gargle in process, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use Oral cleaner cleaning oral cavity.Gargle and oral cavity cleaning through 10 days above-mentioned, this experimenter finds that oral cavity is more pure and fresh.
embodiment 10
Experimenter No. 9 is 33 years old male, oral health.This experimenter firmly gargles 30 seconds by the solution product 1 in embodiment 1.Gargle in process, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use Oral cleaner cleaning oral cavity.Gargle and oral cavity cleaning through 15 days above-mentioned, this experimenter finds that oral cavity is more pure and fresh.
The test result of embodiment 2-10 is as shown in table 1.
Table 1 uses the test result of solution product and Oral cleaner
embodiment 11
Experimenter No. 1, No. 2 and No. 5, use the solution product 1 in embodiment 1 to gargle; After half an hour, these experimenters start to use Oral cleaner cleaning oral cavity.Time clean, these experimenters find that there is uncomfortable sensation at some position, oral cavity, and the position of these discomforts is exactly stomatitis speckle and stomatitis knot location.Through gargling and oral cavity cleaning in a few days, the inflammatory reaction at these positions obtains removing.Subsequently, after gargling with above-mentioned solution, then when carrying out oral cavity cleaning with Oral cleaner, these experimenters find just do not have uncomfortable sensation in oral cavity.Therefore, by using above-mentioned mouthwash solution and Oral cleaner, the improvement situation of oral health just effectively can be detected.
embodiment 12
The solution product 1 that following experimenter only only used in embodiment 1 is gargled, and just finds that above-mentioned solution can slow down or remove oral ulcer.As shown in table 2, in 7 experimenters, there are 3 experimenters (10,11 and No. 12) to gargle with above-mentioned solution and once just relieve the misery of oral ulcer; 2 (experimenters 15 and No. 16) wherein gargling just relieves the misery of oral ulcer for 2 times; There is 1 (experimenter No. 14) to gargle and just relieve the misery of oral ulcer for 4 times; 1 experimenter (No. 13) that has wherein gargles 8 times with above-mentioned solution, and after each use, the symptom of oral ulcer is obtained for alleviation.
Table 2 is used alone the test result of solution product
embodiment 13
Experimenter No. 1 and No. 2, also test solution product 2,3,4 and 5, finds that solution product 2,3,4 and 5 also can slow down oral ulcer symptom effectively.
Table 3 uses the test result of the solution product 2-5 in embodiment 1
Above-mentioned embodiment shows, adopts solution product of the present invention to gargle and can effectively slow down or remove the symptom of oral ulcer.
embodiment 14
Research of the present invention shows, oral ulcer caused by inflammatory reaction, this inflammatory reaction not only only occurs in oral cavity, also other position or the organ of health can be occurred in, such as skin is often injured, if do not obtained medical treatment in time, likely can cause infection, cause inflammatory reaction, the similar ulcer of its symptom.
Have an experimenter (No. 17,51 years old, women) finger injuries in this research process, cured in time, the skin of finger is infected, has the symptoms such as red and swollen and pain.This experimenter cleans finger injuries place 30 seconds with above-mentioned solution, and find that above-mentioned solution can remove the misery of finger pain effectively, the wound of this experimenter is healed subsequently.
As can be seen here, above-mentioned solution is conducive to removing infected or caused by inflammatory reaction pain, is conducive to the cleaning of wound, and wound healing.Above-mentioned solution product can be alleviated or eliminate the inflammation reaction.
Instance parameter disclosed in this invention can change to some extent, but does not affect inventive concept involved in the present invention, does not therefore limit to claim involved in the present invention.
List of references:
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KantarciA,OyaizuK&VanDykeTE.(2003)Neutrophil-mediatedtissueinjuryinperiodontaldiseasepathogenesis:Findingsfromlocalizedaggressiveperiodontitis.JPeriodontol.74:66–75.
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Claims (12)
1. alleviate or remove the solution product tying the oral ulcer relevant with stomatitis speckle to stomatitis, it is characterized in that,
Described solution product, in often liter of solution, comprises 100 grams of ethanol, 9 grams of sodium chloride, 10 grams of ascorbic acid, 0.2 gram of hibitane glucose, 0.3 gram of sucralose and 0.011 gram of phenol red sodium; Or
Described solution product, in often liter of solution, comprises 300 grams of ethanol, 1 gram of sodium chloride, 30 grams of ascorbic acid, 1.0 grams of hibitane glucoses, 0.01 gram of sucralose and 0.011 gram of phenol red sodium; Or
Described solution product, in often liter of solution, comprises 1 gram of ethanol, 30 grams of sodium chloride, 1 gram of ascorbic acid, 0.01 gram of hibitane glucose, 1.0 grams of sucralose and 0.011 gram of phenol red sodium; Or
Described solution product, in often liter of solution, comprises 100 grams of ethanol, 9 grams of sodium chloride, 10 grams of citric acids, 0.2 gram of hibitane glucose, 0.3 gram of sucralose and 0.011 gram of phenol red sodium; Or
Described solution product, in often liter of solution, comprises 100 grams of ethanol, 9 grams of potassium chloride, 10 grams of ascorbic acid, 0.2 gram of hibitane glucose, 0.3 gram of sucralose and 0.011 gram of phenol red sodium.
2. solution product as claimed in claim 1, it is characterized in that, described solution product is collutory or the clear scorching water for cleaning a wound.
3. solution product as claimed in claim 1 or 2, it is characterized in that, described solution product is aqueous solution or glucose solution.
4. solution product as claimed in claim 3, it is characterized in that, the concentration of glucose in described glucose solution is 0.1-15%w/v.
5., for alleviating or removing the combination product tying the oral ulcer relevant with stomatitis speckle to stomatitis, it is characterized in that, described combination product comprises the solution product according to any one of claim 1-4.
6. combination product as claimed in claim 5, is characterized in that, described combination product comprises instrument for detecting stomatitis speckle and stomatitis knot position, place in mouth and/or utensil further.
7. combination product as claimed in claim 6, it is characterized in that, described instrument and/or napkin bag contain: main body, cervical region and head, arrange can tie with stomatitis the function part fully contacted with stomatitis speckle at its head.
8. combination product as claimed in claim 6, it is characterized in that, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of solution or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis.
9. the combination product according to any one of claim 5-8, is characterized in that, described combination product comprise further for remove stomatitis speckle and stomatitis knot instrument and/or utensil.
10. combination product as claimed in claim 9, it is characterized in that, described instrument and/or napkin bag contain: main body, cervical region and head, arrange the function part that can loosen and remove stomatitis speckle and stomatitis knot at its head.
11. combination products as claimed in claim 9, it is characterized in that, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and one or more in antiinflammatory tool, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) of solution or mastic can be carried, described strigil (4) covers on head (3), can to tie fully contact with stomatitis speckle with stomatitis.
12. solution product according to any one of claim 1-4 or the combination product according to any one of claim 5-11 are for the preparation of alleviating or removing the application of to tie to stomatitis in the product of the oral ulcer relevant with stomatitis speckle.
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| WO2020015731A1 (en) * | 2018-07-20 | 2020-01-23 | 北京蔚蓝之源医药科技有限公司 | Uses of sulfoxide compound for preventing radiation-induced oral mucositis and related radiotherapy complications |
| CN115429727A (en) * | 2022-08-12 | 2022-12-06 | 上海弗艾柏生物科技有限公司 | Pet oral cavity repairing tooth cleaning water and preparation method thereof |
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| CN1316248A (en) * | 2001-03-30 | 2001-10-10 | 余隆成 | Nursing liquid for oral cavity of baby |
| CN101785710A (en) * | 2010-02-12 | 2010-07-28 | 潘申权 | Tool for clearing stomatitis spots and stomatitis nodes, and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1316248A (en) * | 2001-03-30 | 2001-10-10 | 余隆成 | Nursing liquid for oral cavity of baby |
| CN101785710A (en) * | 2010-02-12 | 2010-07-28 | 潘申权 | Tool for clearing stomatitis spots and stomatitis nodes, and application thereof |
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