CN103385802A - Solution product and combined product alleviating or removing stomatitis nodules and stomatitis spots, and application thereof - Google Patents
Solution product and combined product alleviating or removing stomatitis nodules and stomatitis spots, and application thereof Download PDFInfo
- Publication number
- CN103385802A CN103385802A CN2012101574983A CN201210157498A CN103385802A CN 103385802 A CN103385802 A CN 103385802A CN 2012101574983 A CN2012101574983 A CN 2012101574983A CN 201210157498 A CN201210157498 A CN 201210157498A CN 103385802 A CN103385802 A CN 103385802A
- Authority
- CN
- China
- Prior art keywords
- stomatitis
- gram
- speckle
- solution
- knot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000003265 stomatitis Diseases 0.000 title claims abstract description 243
- 239000000243 solution Substances 0.000 claims abstract description 155
- 210000000214 mouth Anatomy 0.000 claims abstract description 112
- 206010061218 Inflammation Diseases 0.000 claims abstract description 75
- 230000004054 inflammatory process Effects 0.000 claims abstract description 74
- 238000004140 cleaning Methods 0.000 claims abstract description 46
- 208000007117 Oral Ulcer Diseases 0.000 claims abstract description 43
- 201000001245 periodontitis Diseases 0.000 claims abstract description 36
- 206010006326 Breath odour Diseases 0.000 claims abstract description 33
- 208000032139 Halitosis Diseases 0.000 claims abstract description 30
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 8
- 239000000047 product Substances 0.000 claims description 108
- 208000002399 aphthous stomatitis Diseases 0.000 claims description 41
- 210000003128 head Anatomy 0.000 claims description 41
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 38
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 38
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 34
- 235000001727 glucose Nutrition 0.000 claims description 28
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 25
- 239000008103 glucose Substances 0.000 claims description 25
- 230000035807 sensation Effects 0.000 claims description 25
- 235000019615 sensations Nutrition 0.000 claims description 25
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 22
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 claims description 22
- 239000004376 Sucralose Substances 0.000 claims description 22
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 22
- 229960003531 phenolsulfonphthalein Drugs 0.000 claims description 22
- 229910052708 sodium Inorganic materials 0.000 claims description 22
- 239000011734 sodium Substances 0.000 claims description 22
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 22
- 235000019408 sucralose Nutrition 0.000 claims description 22
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 19
- 235000010323 ascorbic acid Nutrition 0.000 claims description 19
- 229960005070 ascorbic acid Drugs 0.000 claims description 19
- 239000011668 ascorbic acid Substances 0.000 claims description 19
- 230000036541 health Effects 0.000 claims description 19
- 239000011780 sodium chloride Substances 0.000 claims description 19
- 239000013066 combination product Substances 0.000 claims description 18
- 229940127555 combination product Drugs 0.000 claims description 18
- 231100000915 pathological change Toxicity 0.000 claims description 15
- 230000036285 pathological change Effects 0.000 claims description 15
- 230000014860 sensory perception of taste Effects 0.000 claims description 15
- 241000124008 Mammalia Species 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 230000006870 function Effects 0.000 claims description 11
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 10
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 10
- 239000013521 mastic Substances 0.000 claims description 10
- 244000005700 microbiome Species 0.000 claims description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 235000015165 citric acid Nutrition 0.000 claims description 5
- 235000011164 potassium chloride Nutrition 0.000 claims description 5
- 239000001103 potassium chloride Substances 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- -1 hibitane glucoses Chemical class 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 210000004872 soft tissue Anatomy 0.000 abstract description 8
- 206010052428 Wound Diseases 0.000 abstract description 6
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 239000002324 mouth wash Substances 0.000 abstract description 2
- 229940051866 mouthwash Drugs 0.000 abstract description 2
- 230000001815 facial effect Effects 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000013049 sediment Substances 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 description 40
- 231100000397 ulcer Toxicity 0.000 description 38
- 238000005070 sampling Methods 0.000 description 33
- 210000000440 neutrophil Anatomy 0.000 description 26
- 230000008569 process Effects 0.000 description 15
- 230000002757 inflammatory effect Effects 0.000 description 13
- 208000024891 symptom Diseases 0.000 description 9
- 210000004400 mucous membrane Anatomy 0.000 description 8
- 230000000306 recurrent effect Effects 0.000 description 8
- 230000028327 secretion Effects 0.000 description 8
- 206010028034 Mouth ulceration Diseases 0.000 description 6
- DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 description 6
- DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- 208000025157 Oral disease Diseases 0.000 description 5
- 210000004195 gingiva Anatomy 0.000 description 5
- 208000030194 mouth disease Diseases 0.000 description 5
- 210000004877 mucosa Anatomy 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 230000035943 smell Effects 0.000 description 5
- 206010035148 Plague Diseases 0.000 description 4
- 241000607479 Yersinia pestis Species 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000001097 facial muscle Anatomy 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000003239 periodontal effect Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 208000012880 Finger injury Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000001925 catabolic effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000010794 food waste Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 208000024693 gingival disease Diseases 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000002741 palatine tonsil Anatomy 0.000 description 2
- 208000028169 periodontal disease Diseases 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 108010008364 Melanocortins Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010033474 Pain of skin Diseases 0.000 description 1
- 229920012196 Polyoxymethylene Copolymer Polymers 0.000 description 1
- 108010069820 Pro-Opiomelanocortin Proteins 0.000 description 1
- 102100027467 Pro-opiomelanocortin Human genes 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000001277 chronic periodontitis Diseases 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000007236 host immunity Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 229940074869 marquis Drugs 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000002865 melanocortin Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 208000004235 neutropenia Diseases 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- VBUNOIXRZNJNAD-UHFFFAOYSA-N ponazuril Chemical compound CC1=CC(N2C(N(C)C(=O)NC2=O)=O)=CC=C1OC1=CC=C(S(=O)(=O)C(F)(F)F)C=C1 VBUNOIXRZNJNAD-UHFFFAOYSA-N 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 210000005181 root of the tongue Anatomy 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Images
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a solution product used for alleviating or removing stomatitis nodules and stomatitis spots, related oral ulcers, periodontitis and/or halitosis, inflammatory reactions of a similar type, or taste, smell and/or facial lesions induced by stomatitis nodules and stomatitis spots. The solution product is mouthwash or inflammation clearing liquid used for cleaning wounds. Also, the invention provides a combined product comprising the solution product, and an application thereof. The solution product is simple to use. When the solution product is frequently used, soft tissue parts which are hard to clean in oral cavities can be effectively cleaned, residual microbes and sediments in oral cavity can be removed, such that oral cleanness and sanitation are ensured, and halitosis can be prevented and treated. With solution product and combined product provided by the invention, stomatitis nodules and stomatitis spots, which are sources of oral cavity inflammations, can be effectively removed; and oral ulcers, periodontitis and other diseases induced by stomatitis nodules can be effectively treated.
Description
Technical field
The invention belongs to field of oral care, relate to a kind of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied and solution product, combination product and the application thereof of the sense of taste, olfactory sensation and shape of face pathological changes that the stomatitis speckle brings out by stomatitis.
Background technology
Overwhelming majority people sooner or later brushes teeth twice every day, has many people also to clean one's teeth on schedule, but a lot of people also has oral problem, as oral ulcer, inflammation, periodontitis and halitosis.According to statistical analysis, the crowd more than 90% suffers from oral disease in various degree, as problems such as periodontitis, dental caries, oral ulcer and halitosiss.
Oral ulcer, be commonly called as oral cavity and get angry, and directly affects work efficiency.One to work strain and busy time, will play BAIPAO in a lot of people's oral cavity, allow people's hurt like hell.This had both affected people's work efficiency, perplexed again people's mood.Recurrent oral ulceration is perplexing a lot of crowds, its unknown etiology as yet.
Oral inflammation affects the curative effect of multiple oral medical measure (as plantation, correction).The patient that oral inflammation is heavier, often after plantation or correction, its medical effect is not ideal enough, even causes malpractice.Lowering and controlling oral inflammation is the prerequisite of planting with the medical measure such as correction.
Periodontitis not only can cause the loosening of tooth and come off, and affect whole healthy.Periodontitis and major disease (as heart disease, diabetes and old apoplexy) are closely related, also are considered to after cancer and heart disease, threaten the third-largest killer of human health.The order of severity of periodontitis in different patients differs widely; Effect after periodontal scaling also is limited by the host immunity function that can not control.
Halitosis is one allows the very awkward problem of people.In this modern society that payes attention to personal image, halitosis directly affects the work relationship of with other people, getting along, and also affects individual's self-confidence and image.Everyone does not wish that any mishap and defect are arranged on this problem.Halitosis is often perplexing a lot of people on the hop.
These different oral problem have a common feature: they have a kind of uncertainty that is difficult to predict.Exist a kind of X factor in this explanation oral cavity and affecting oral health.
Up-to-date research is found: exist in oral cavity a kind of before by inflammation source that the mankind understood; This newfound oral inflammation source directly affects the multiple oral problem in oral cavity.This source, new oral cavity is referred to as " stomatitis speckle " (Oral Inflammatory Plague) and " stomatitis knot " (Oral Inflammatory Knotitis) (specifically referring to Chinese invention patent application CN201010109442.1).
People often only clean tooth.Be not cleaned if account for other position in the oral cavity of greater part, can cause food debris and bacterial adsorption, remain in the oral soft tissue that is not easy to be cleaned, thereby form the source of oral inflammation.Inflammation is the incitant of oral ulcer, periodontitis and other oral disease.
The oral inflammation source of this new cognition occurs in the soft tissue position that inside, oral cavity is not easy to clear up, mainly appear at the position, oral cavity that existing oral appliance can not effectively be cleared up, intersection as (1) gingiva root and oral cavity wall, the i.e. close region of " mucosa gum circle " (mucogingival junction), (2) oral cavity wall, (3) root of the tongue inwall, (4) tongue bottom, and (5) oral cavity and tongue intersection.
Because above-mentioned position can not be cleared up effectively, different materials deposit at this, and this comprises antibacterial and food waste.These deposits can bring out the immunocyte of human body, particularly neutrophils (Neutrophil), assemble in a large number this place.But these immunocytes are to remove sedimental that these have hardened.These immunocytes discharge multiple catabolic enzyme and toxicant (Miller et al 1984; Kantarci et al 2003), and immune response signal, thereby inflammatory reaction (Wright et al1986 brought out; Cassatella 2003; Serhan﹠amp; Savill 2005), thus " stomatitis speckle " (Oral Inflammatory Plague) formed.
The existence of stomatitis speckle will be brought out the Soft Tissue Deformation of periphery, and the stomatitis speckle is wrapped in wherein.Because region of interest can not effectively be cleared up, new precipitate continues deposition at this, thereby brings out the formation of more stomatitis speckle.Soft tissue on every side also will be out of shape, and these stomatitis speckles are encased, and a large amount of gatherings of stomatitis speckle, will form " stomatitis knot " (Oral Inflammatory Knotitis).
Summary of the invention
For successfully manage stomatitis speckle and stomatitis knot, the invention provides alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied and Related product and the application thereof of the sense of taste, olfactory sensation and shape of face pathological changes that the stomatitis speckle brings out by stomatitis.
, for helping to understand the present invention, some terms have below been defined.Term defined herein has the implication that those of ordinary skill in the related art of the present invention understand usually.
Unless otherwise indicated, term used herein " stomatitis speckle " (Oral Inflammatory Plague) refers to be present in gathering colony in oral soft tissue, that bring out the immunocyte of oral inflammation reaction.
Unless otherwise indicated, term used herein " stomatitis knot " (Oral Inflammatory Knotitis) refers to be present in gathering colonies in oral soft tissue, that bring out oral inflammation reaction, numerous stomatitis speckles.
Stomatitis speckle and stomatitis knot are the sources of oral inflammation.Inflammation is the incitant of oral ulcer, periodontitis and other oral disease.
Unless otherwise indicated, term used herein " clear scorching water " (Inflammation-removing solution) refer to alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied and the solution product of the sense of taste, olfactory sensation and shape of face pathological changes that the stomatitis speckle brings out by stomatitis; Described inflammation comprises the inflammatory reaction of oral cavity or other position of health or organ.
Stomatitis speckle and stomatitis knot occur in inside, oral cavity, bring out therefrom the oral inflammation reaction.Also can occur in other position or the organ of health with its inflammatory reaction roughly the same, such as skin injured after,, if in time do not obtain medical treatment, likely can cause infection, cause inflammatory reaction, the similar ulcer of its symptom.
Unless otherwise indicated, term used herein " with its inflammatory reaction roughly the same " refers to occur in other position beyond oral cavity or the inflammatory reaction of organ, and its genesis mechanism is analogous to by stomatitis speckle and stomatitis knot brings out the oral inflammation reaction; Its inflammatory reaction can be alleviated or remove to the clear scorching water that this paper provides.
In order to solve the problems of the technologies described above, an object of the present invention is to provide a kind of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied and the solution product of the sense of taste, olfactory sensation and/or shape of face pathological changes that the stomatitis speckle brings out by stomatitis.
Another object of the present invention be to provide a kind of for alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied and the combination product of the sense of taste, olfactory sensation and/or shape of face pathological changes that the stomatitis speckle brings out by stomatitis.
Another purpose of the present invention be to provide above-mentioned solution product or above-mentioned combination product for the preparation of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied by stomatitis and the product of the sense of taste, olfactory sensation and/or shape of face pathological changes that the stomatitis speckle brings out in application.
A further object of the present invention be to provide a kind of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied and the method for the sense of taste, olfactory sensation and/or shape of face pathological changes that the stomatitis speckle brings out by stomatitis.
Another object of the present invention is to provide a kind of method that detects stomatitis knot and position, stomatitis speckle place.
Also purpose of the present invention is to provide a kind of mammal oral health that detects and improves the method for situation.
The objective of the invention is to be achieved through the following technical solutions:
On the one hand, the invention provides a kind of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied and the solution product of the sense of taste, olfactory sensation and/or shape of face pathological changes that the stomatitis speckle brings out by stomatitis; Described solution product is preferably collutory or is used for the clear scorching water that cleans a wound, and described solution product comprises organic solvent, salt and the acid for stomatitis speckle in soft and delivering oral and stomatitis knot or alleviation or eliminate the inflammation reaction.
Preferably, described organic solvent is selected from one or more in the agent solvent of having of ethanol, dimethyl sulfoxide and other effective and safe, described salt is selected from one or more in the salt of sodium chloride, potassium chloride and other effective and safe, and described acid is selected from one or more in the acid of ascorbic acid, citric acid and other effective and safe.
Preferably, described solution product further comprises for the compound that suppresses or kill oral microorganism.
Preferably, described inhibition or the compound that kills oral microorganism are: the hibitane glucose.
Preferably, described solution product further comprises the compound for the taste of regulating this solution product.
Preferably, the compound of described taste for regulating this solution product is: sucralose.
Preferably, described solution product further comprises for painted compound.
Preferably, describedly for painted compound, be: phenol red sodium.
Preferably, described solution product, in every liter of solution, comprises: 1-300 gram ethanol, 1-30 gram sodium chloride, 1-30 gram ascorbic acid, 0.01-1.00 gram hibitane glucose, 0.01-1.00 gram sucralose and the phenol red sodium of 0.01-0.02 gram.
Preferably, described solution product, in every liter of solution, comprises 100 gram ethanol, 9 gram sodium chloride, 10 gram ascorbic acid, 0.2 gram hibitane glucose, 0.3 gram sucralose and the phenol red sodium of 0.011 gram.
Preferably, described solution product, in every liter of solution, comprises 300 gram ethanol, 1 gram sodium chloride, 30 gram ascorbic acid, 1.0 gram hibitane glucoses, 0.01 gram sucralose and the phenol red sodium of 0.011 gram.
Preferably, described solution product, in every liter of solution, comprises 1 gram ethanol, 30 gram sodium chloride, 1 gram ascorbic acid, 0.01 gram hibitane glucose, 1.0 gram sucralose and the phenol red sodium of 0.011 gram.
Preferably, described solution product, in every liter of solution, comprises 100 gram ethanol, 9 gram sodium chloride, 10 gram citric acids, 0.2 gram hibitane glucose, 0.3 gram sucralose and the phenol red sodium of 0.011 gram.
Preferably, described solution product, in every liter of solution, comprises 100 gram ethanol, 9 gram potassium chloride, 10 gram ascorbic acid, 0.2 gram hibitane glucose, 0.3 gram sucralose and the phenol red sodium of 0.011 gram.
Preferably, described solution product, in every liter of solution, comprises 20 gram dimethyl sulfoxide, 9 gram sodium chloride, 10 gram ascorbic acid, 0.2 gram hibitane glucose, 0.3 gram sucralose and the phenol red sodium of 0.011 gram.
Preferably, described solution product is aqueous solution or glucose solution.
Preferably, the concentration of glucose in described glucose solution is 0.1-15%w/v.
On the other hand, the invention provides a kind of for alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied and the combination product of the sense of taste, olfactory sensation and/or shape of face pathological changes that the stomatitis speckle brings out by stomatitis, described combination product comprises above-mentioned solution product.
Preferably, described combination product further comprises instrument and/or the utensil at the position, place in mouth for detection of stomatitis speckle and stomatitis knot.
Preferably, described instrument and/or utensil comprise: main body, cervical region and head, can tie the function part that fully contact with stomatitis speckle and stomatitis its head setting.
Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and the antiinflammatory tool in one or more, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) that can carry solution or mastic, described strigil (4) covers on head (3), can fully contact with the stomatitis knot with the stomatitis speckle.
Preferably, described combination product further comprises for instrument and/or the utensil of removing stomatitis speckle and stomatitis knot.
Preferably, described instrument and/or utensil comprise: main body, cervical region and head, can become flexible and remove the function part of stomatitis speckle and stomatitis knot its head setting.
Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and the antiinflammatory tool in one or more, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) that can carry solution or mastic, described strigil (4) covers on head (3), can fully contact with the stomatitis knot with the stomatitis speckle.
Another aspect, the invention provides above-mentioned solution product or above-mentioned combination product for the preparation of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied by stomatitis and the product of the sense of taste, olfactory sensation and/or shape of face pathological changes that the stomatitis speckle brings out in application.
Again on the one hand, the invention provides a kind of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied and the method for the sense of taste, olfactory sensation and/or shape of face pathological changes that the stomatitis speckle brings out by stomatitis, described method comprises:
1) mammal such as people gargle with appropriate above-mentioned solution product, allow this solution product fully contact with each position in oral cavity;
2) allow the active ingredient of solution product fully soften and soft stomatitis speckle and stomatitis knot;
3) with instrument and/or the utensil that can detect stomatitis speckle and stomatitis knot position, place in mouth, each position of massaging oral, find uncomfortable part; Uncomfortable part is stomatitis speckle and stomatitis knot position, place;
Preferably, described instrument and/or utensil comprise: main body, cervical region and head, can tie the function part that fully contact with stomatitis speckle and stomatitis its head setting;
Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and the antiinflammatory tool in one or more, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) that can carry solution or mastic, described strigil (4) covers on head (3), can fully contact with the stomatitis knot with the stomatitis speckle;
4) with instrument and/or the utensil that can remove stomatitis speckle and stomatitis knot, the position at massage and cleaning stomatitis speckle and stomatitis knot place;
Preferably, described instrument and/or utensil comprise: main body, cervical region and head, can become flexible and remove the function part of stomatitis speckle and stomatitis knot its head setting;
Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and the antiinflammatory tool in one or more, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) that can carry solution or mastic, described strigil (4) covers on head (3), can fully contact with the stomatitis knot with the stomatitis speckle.
Preferably, step 1), the time of gargling is 30 seconds; Step 2) the required time was more than 5 minutes.
On the other hand, the invention provides a kind of method that detects stomatitis knot and position, stomatitis speckle place, described method comprises:
1) mammal such as people gargle with appropriate above-mentioned solution product, allow this solution product fully contact with each position in oral cavity;
2) allow the active ingredient of solution product fully soften and soft stomatitis speckle and stomatitis knot;
3) with instrument and/or the utensil that can detect stomatitis speckle and stomatitis knot position, place in mouth, each position of massaging oral, find uncomfortable part; Uncomfortable part is stomatitis speckle and stomatitis knot position, place;
Preferably, described instrument and/or utensil comprise: main body, cervical region and head, can tie the function part that fully contact with stomatitis speckle and stomatitis its head setting;
Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and the antiinflammatory tool in one or more, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) that can carry solution or mastic, described strigil (4) covers on head (3), can fully contact with the stomatitis knot with the stomatitis speckle;
Preferably, step 1), the time of gargling is 30 seconds; Step 2) the required time was more than 5 minutes.
Also on the one hand, the invention provides a kind of mammal oral health that detects and improve the method for situation, described method comprises:
Before the mammal oral health is improved and afterwards, according to said method, detect respectively stomatitis speckle and stomatitis knot position, place in the mammal oral cavity, before then relatively improving and stomatitis speckle afterwards and stomatitis knot have a situation.
Preferably, described mammal is the people.
The present invention has disclosed how to remove by following research and has occurred and embed inflammation source in oral cavity mucous membrane tissue.Remove this inflammation source, the chronic periodontitis that can heal the sick and regular ulcer.This shows, the inflammation that embeds mucous membrane tissue is a kind of inducement of the oral disease relevant to inflammation.On the basis of this research, the present invention sets up the organic assembling by solution product and Oral cleaner, thoroughly removes the method for stomatitis speckle and stomatitis knot.
The experimenter who suffers from oral ulcer, periodontitis, inflammation and/or halitosis that stomatitis knot and stomatitis speckle bring out firmly gargled 30 seconds with solution product of the present invention, in the process of gargling, allowed solution product fully contact each position in oral cavity.
After five minutes, this experimenter starts to use the Oral cleaner cleaning oral cavity, the described Oral cleaner of patent (specifically referring to Chinese invention patent application CN201010109442.1) before described Oral cleaner comprises (for example: remove scorching brush, the tool that unhitches, node-slackening brush and wash scorching brush).In cleaning course, there is uncomfortable sensation at some position of this subject oral cavity.Then, to these positions, carry out carefully concentrating and cleaning.In oral cavity do not feel well, gargle with this solution product, find that the discomfort in oral cavity has obvious alleviation.
The residue that turns white in cleaning process from then on position discharges, and has once in a while the appearance of bloodstain, but the continuous bleeding phenomenon does not occur.Subsequently, ulcer sampling point (ulcer-like spot) occurs on the mucous membrane tissue of nigh mucosa gingiva intersection.Surprisingly, brown secretions discharges from the ulcer sampling point.This secretions dyes with T ü rk ' s solution, then observes under fluorescence microscope.Obviously, contain a large amount of neutrophils (neutrophil) in this secretions, these cells all contain typical polymorphonuclear feature.This sample is dyeed by acridine orange (Acridine orange), is proved and contains neutrophils under fluorescence microscope.
As if this brown secretions contains a neutrophils with construction unit and assembles colony, and the neutrophils colony that these pool together is referred to as stomatitis speckle (oral inflammatory plague).The neutrophils that occurs in brown secretions is a kind of inflammatory symptom; Neutrophils discharges can damage tooth and the catabolic enzyme of tissue.Can discharge a plurality of stomatitis speckles from a ulcer sampling point, the ulcer sampling point is cured subsequently.Then the stomatitis speckle will can not discharge again from the position of suffering from the ulcer sampling point.The stomatitis speckle is present in the time marquis in the ulcer sampling point, and the patient can have at this position a kind of temperature and uncomfortable sensation.In case the stomatitis speckle is released, the patient just feels a kind of sensation as if relieved of a heavy load at once.These show that all the stomatitis speckle is a kind of inflammatory reaction.
By inference, the stomatitis speckle is embedded in mucous membrane tissue.Support the fact of this idea to be, need to take time and with strength, the stomatitis speckle be discharged from mucous membrane tissue.A lot of stomatitis speckles can pool together, and due to folding of mucous membrane tissue, the stomatitis speckle is embedded, and forms a kind of " knot " columnar structure, is referred to as " stomatitis knot " (oral inflammatory knotitis).The stomatitis knot can cause visible inflammatory symptom, as above-mentioned said ulcer sampling point.May be caused by the cell death due to neutrophils at the visible White residule in ulcer sampling point place or precipitate.
, by the process of except scorching brush, cleaning, find in this patient oral cavity to contain a plurality of ulcer sampling points.These ulcer sampling points are present near mucosa gingiva intersection, tongue is following, near palatine tonsil, and inner at cheek; These are all the places that can not be cleared up by current oral cavity cleaning measure easily.Some ulcer sampling point, than other more difficult removing, may be because due to its position, place, size and complexity.The number of the stomatitis speckle that discharges from a ulcer sampling point is different.Some stomatitis speckles are brown, and some stomatitis speckles are yellow.
After the ulcer sampling point was eliminated, this patient noticed that he has not had periodontal disease.This shows removes the effective measures that the ulcer sampling point is the treatment periodontitis.Amazing is that along with the further removing of ulcer sampling point, patient's oral ulcer is less generation also.After the ulcer sampling point was removed end, this patient had also no longer suffered the puzzlement of oral ulcer.This shows that oral inflammation is the inducement that causes the oral cavity recurrent ulcer.
This patient also notices, after the ulcer sampling point was removed, his problem of bad breath was also eliminated.Can imagine, the microorganism that is trapped in ulcer sampling point the inside is the reason (Fig. 1) that causes halitosis.What is interesting is, his sensory system has improved, and he can smell more abnormal smells from the patient.By inference, the neutrophils in oral cavity may be destroyed the sensory cell in respiratory system.Therefore, remove the ulcer sampling point and can treat gum disease, also be of value to healthy.
Stomatitis speckle and stomatitis knot occur in inside, oral cavity, bring out therefrom the oral inflammation reaction.This inflammatory reaction meeting causes the tight and distortion of oral cavity wall muscle, brings out therefrom corresponding face position distortion herein, even brings out face's wrinkle.This patient after all stomatitis speckles of having removed inside, oral cavity and stomatitis knot, finds that his facial muscle has more elasticity, and face is more smooth.This shows, the inwall of rinsing the mouth is conducive to face health.
These researchs show, the deficiency of current oral sanitary habit, caused food residue, the accumulation of cell debris (white depositions) and microorganism (problem of bad breath), and these will bring out the gathering (Fig. 1) of neutrophils.Yet neutrophils can not be removed and be present in residue, fragment and microorganism precipitate hidden area, that hardened.This regional neutrophils is assembled colony will cause the stomatitis speckle, discharge inflammatory factor and destructive material.Oral cavity mucous membrane tissue folds and the formation of more stomatitis speckles in this zone, will cause stomatitis knot (knotitis), thereby induce visible inflammatory symptom, as oral ulcer or ulcer sampling point.Along with the growth of stomatitis knot, inflammation will further increase the weight of, thereby cause oral disease, as the appearance of periodontitis.Being present in residue, fragment and microorganism precipitate hidden area, that hardened is to bring out the source that neutrophils is assembled, caused inflammatory reaction.
Through treatment after a while, this experimenter's various oral problem, this comprises recurrent oral ulceration, periodontitis and halitosis, improves significantly.
The positive beneficial effect that the present invention has:
1. solution product of the present invention is easy to use, the frequent effective clean-up port intracavity section soft tissue position that is not easy to clear up of use, and removing remains in microorganism and the deposit in oral cavity, makes the oral cavity cleaning health, prevents and treats halitosis; Can alleviate significantly the oral cavity sense of discomfort, make oral cavity fresh and cool, taste and smell is sensitiveer, makes tongue have more elasticity and retractility, is conducive to speak more smooth.
2. stomatitis speckle and stomatitis knot occur in inside, oral cavity, bring out therefrom the oral inflammation reaction.This inflammatory reaction meeting causes the tight and distortion of oral cavity wall muscle, brings out therefrom corresponding face position distortion herein, even brings out face's wrinkle.The stomatitis speckle of removing inside, oral cavity and stomatitis have to be beneficial to and make facial muscle have more elasticity, and face is more smooth.This shows, the inwall of rinsing the mouth is conducive to face health.
3. other position of health or organ are often injured because of a variety of causes.Such as skin injured after,, if can not in time obtain medical treatment, just likely cause infection, cause inflammatory reaction.The roughly the same oral inflammation reaction brought out of stomatitis speckle and stomatitis knot of this inflammatory reaction; Use clear scorching water of the present invention can slow down inflammation and the pain of skin wound.Therefore, use clear scorching water of the present invention to be conducive to the healing of wound.
4. combination product of the present invention, forming a complete set of of the solution product of the application of the invention and Oral cleaner, can effectively treat oral ulcer, periodontitis and Other diseases that the patient brings out because of the stomatitis knot; Form a complete set of with existing Oral cleaner, can effectively remove stomatitis speckle and stomatitis knot, all stomatitis speckles are released.Described Oral cleaner is preferably as comprising except scorching brush, the tool that unhitches, node-slackening brush and washing the scorching Oral cleaner of brushing described in Chinese invention patent application CN201010109442.1.
5. the solution product of the application of the invention and combination product, the source that can effectively eliminate oral inflammation: stomatitis speckle and stomatitis knot; According to the formation mechanism of stomatitis speckle and stomatitis knot, the present invention reaches the effect of thorough removing stomatitis speckle and stomatitis knot.
Description of drawings
Below, describe by reference to the accompanying drawings embodiment of the present invention in detail, wherein:
Fig. 1 is the model that is inflamed in oral cavity and proposes.
Fig. 2 is the neutrophils in the stomatitis speckle, wherein 2A:, with Tt ü rk ' s solution-dyed, show that the stomatitis speckle contains a large amount of neutrophils; Its cell has typical polymorphonuclear feature; 2B: sample is with acridine orange (Acridine orange) dyeing, at the fluorescence microscopy Microscopic observation.
Fig. 3 is the antiinflammatory tool, comprises main body (1), cervical region (2), head (3) and strigil (4).
The specific embodiment
Below in conjunction with specific embodiment, and comparable data describes in further detail the present invention.Should be understood that these embodiment just in order to demonstrate the invention, but not limit by any way scope of invention.
In following embodiment, various processes and the method do not described in detail are conventional methods as known in the art.
The solution product that comprises following composition according to the conventional method preparation:
Solution product 1 (in every liter of solution) contains: 100 gram ethanol, and 9 gram sodium chloride, 10 gram ascorbic acid, 0.2 gram hibitane glucose, 0.3 gram sucralose and the phenol red sodium of 0.011 gram, all the other are water.
Solution product 2 (in every liter of solution) contains: 300 gram ethanol, and 1 gram sodium chloride, 30 gram ascorbic acid, 1.0 gram hibitane glucoses, 0.01 gram sucralose and the phenol red sodium of 0.011 gram, all the other are water.
Solution product 3 (in every liter of solution) contains: 1 gram ethanol, and 30 gram sodium chloride, 1 gram ascorbic acid, 0.01 gram hibitane glucose, 1.0 gram sucralose and the phenol red sodium of 0.011 gram, all the other are water.
Solution product 4 (in every liter of solution) contains: 100 gram ethanol, and 9 gram sodium chloride, 10 gram citric acids, 0.2 gram hibitane glucose, 0.3 gram sucralose and the phenol red sodium of 0.011 gram, all the other are water.
Solution product 5 (in every liter of solution) contains: 100 gram ethanol, and 9 gram potassium chloride, 10 gram ascorbic acid, 0.2 gram hibitane glucose, 0.3 gram sucralose and the phenol red sodium of 0.011 gram, all the other are water.
Solution product 6 (in every liter of solution) contains: 20 gram dimethyl sulfoxide, and 9 gram sodium chloride, 10 gram ascorbic acid, 0.2 gram hibitane glucose, 0.3 gram sucralose and the phenol red sodium of 0.011 gram, all the other are water.
The experimenter is 51 years old male No. 1, suffers from the periodontitis of 17 years, also often suffers the puzzlement of oral ulcer.This experimenter firmly gargled 30 seconds with the solution product 1 in embodiment 1, in the process of gargling, allowed solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use the Oral cleaner cleaning oral cavity, and described Oral cleaner comprises the Oral cleaner (for example: remove scorching brush, the tool that unhitches, node-slackening brush and/or wash scorching brush) described in Chinese invention patent application CN201010109442.1.In cleaning course, this experimenter finds that he has uncomfortable sensation in some position in oral cavity.Then he, to these positions, carries out carefully concentrating and cleaning.In oral cavity do not feel well, he gargled with this solution product, found that the discomfort in oral cavity has obvious alleviation.
Through cleaning, the residue that turns white from then on position discharges, and has once in a while the appearance of bloodstain, but the continuous bleeding phenomenon does not occur.Subsequently, ulcer sampling point (ulcer-like spot) occurs on the mucous membrane tissue of nigh mucosa gingiva intersection.Surprisingly, brown secretions discharges from the ulcer sampling point.This secretions Ttrk ' s solution dyes, and then observes under fluorescence microscope.Obviously, contain a large amount of neutrophils (neutrophil) in this secretions, these cells all contain typical polymorphonuclear feature.This sample is dyeed by acridine orange (Acridine orange), is proved under fluorescence microscope and contains neutrophils (Fig. 2).
, by the process of except scorching brush, cleaning, find in this patient oral cavity to contain a plurality of ulcer sampling points.These ulcer sampling points are present near mucosa gingiva intersection, tongue is following, near palatine tonsil, and inner at cheek; These are all the places that can not be cleared up by current oral cavity cleaning measure easily.Some ulcer sampling point, than other more difficult removing, may be because due to its position, place, size and complexity.The number of the stomatitis speckle that discharges from a ulcer sampling point is different.Some stomatitis speckles are brown, and some stomatitis speckles are yellow.
After the ulcer sampling point was eliminated, this patient noticed that he has not had periodontal disease.This shows removes the effective measures that the ulcer sampling point is the treatment periodontitis.Amazing is that along with the further removing of ulcer sampling point, patient's oral ulcer is less generation also.After the ulcer sampling point was removed end, this patient had also no longer suffered the puzzlement of oral ulcer.This shows that oral inflammation is the inducement that causes the oral cavity recurrent ulcer.
This patient also notices, after the ulcer sampling point was removed, his problem of bad breath was also eliminated.Can imagine, the microorganism that is trapped in ulcer sampling point the inside is the reason (Fig. 1) that causes halitosis.What is interesting is, his sensory system has improved, and he can smell more abnormal smells from the patient.By inference, the neutrophils in oral cavity may be destroyed the sensory cell in respiratory system.Therefore, remove the ulcer sampling point and can treat gum disease, also be of value to healthy.
Stomatitis speckle and stomatitis knot occur in inside, oral cavity, bring out therefrom the oral inflammation reaction.This inflammatory reaction meeting causes the tight and distortion of oral cavity wall muscle, brings out therefrom corresponding face position distortion herein, even brings out face's wrinkle.This patient after all stomatitis speckles of having removed inside, oral cavity and stomatitis knot, finds that his facial muscle has more elasticity, and face is more smooth.This shows, the inwall of rinsing the mouth is conducive to face health.
Through above-mentioned the gargling and oral cavity cleaning of 25 days, every day 2-3 time, this experimenter's various oral problem, this comprises recurrent oral ulceration, periodontitis and halitosis, improves significantly.
Embodiment 3
The experimenter is for No. 2 30 years old male, often suffers from oral ulcer, and the problems such as halitosis are arranged.This experimenter firmly gargled 30 seconds with the solution product 1 in embodiment 1.In the process of gargling, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use Oral cleaner, antiinflammatory tool shown in Figure 3 for example, cleaning oral cavity.In cleaning course, this experimenter finds that he has uncomfortable sensation in some position in oral cavity.Then he, to these positions, carries out carefully concentrating and cleaning.In oral cavity do not feel well, he gargled with this solution product, found that the discomfort in oral cavity has obvious alleviation.Through above-mentioned the gargling and oral cavity cleaning of 10 days, this experimenter's oral problem, comprised recurrent oral ulceration and halitosis, cured.
The experimenter is 21 years old women No. 3, suffers from oral ulcer.This experimenter firmly gargled 30 seconds with the solution product 1 in embodiment 1.In the process of gargling, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use the Oral cleaner cleaning oral cavity.Through above-mentioned the gargling and oral cavity cleaning of 2 days, this experimenter's oral ulcer was cured.
Embodiment 5
The experimenter is 35 years old male No. 4, suffers from oral ulcer.This experimenter firmly gargled 30 seconds with the solution product 1 in embodiment 1.In the process of gargling, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use the Oral cleaner cleaning oral cavity.Through above-mentioned the gargling and oral cavity cleaning of 3 days, this experimenter's oral ulcer was cured.
Embodiment 6
The experimenter is 62 years old male No. 5, suffers from periodontitis.This experimenter firmly gargled 30 seconds with the solution product 1 in embodiment 1.In the process of gargling, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use the Oral cleaner cleaning oral cavity.In cleaning course, this experimenter finds that he has uncomfortable sensation in some position in oral cavity.Then he, to these positions, carries out carefully concentrating and cleaning.In oral cavity do not feel well, he gargled with this solution product, found that the discomfort in oral cavity has obvious alleviation.Through above-mentioned the gargling and oral cavity cleaning of 10 days, this experimenter's the periodontitis of suffering from improved significantly.
Embodiment 7
The experimenter is 61 years old male No. 6, suffers from recurrent oral ulceration.This experimenter firmly gargled 30 seconds with the solution product 1 in embodiment 1.In the process of gargling, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use the Oral cleaner cleaning oral cavity.In cleaning course, this experimenter finds that he has uncomfortable sensation in some position in oral cavity.Then he, to these positions, carries out carefully concentrating and cleaning.In oral cavity do not feel well, he gargled with this solution product, found that the discomfort in oral cavity has obvious alleviation.Through above-mentioned the gargling and oral cavity cleaning of 6 days, this experimenter's recurrent oral ulceration improved significantly.
Embodiment 8
The experimenter is 34 years old women No. 7, and slight oral inflammation is arranged.This experimenter firmly gargled 30 seconds with the solution product 1 in embodiment 1.In the process of gargling, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use the Oral cleaner cleaning oral cavity.In cleaning course, this experimenter finds that she has uncomfortable sensation in some position in oral cavity.Then she, to these positions, carries out carefully concentrating and cleaning.In oral cavity do not feel well, she gargled with this solution product, found that the discomfort in oral cavity has obvious alleviation.Through above-mentioned the gargling and oral cavity cleaning of 6 days, this experimenter's slight oral inflammation was cured.
Embodiment 9
The experimenter is for No. 8 50 years old women, oral health.This experimenter firmly gargled 30 seconds with the solution product 1 in embodiment 1.In the process of gargling, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use the Oral cleaner cleaning oral cavity.Through above-mentioned the gargling and oral cavity cleaning of 10 days, this experimenter found that oral cavity is more pure and fresh.
Embodiment 10
The experimenter is for No. 9 33 years old male, oral health.This experimenter firmly gargled 30 seconds with the solution product 1 in embodiment 1.In the process of gargling, allow solution product fully contact each position in oral cavity.After five minutes, this experimenter starts to use the Oral cleaner cleaning oral cavity.Through above-mentioned the gargling and oral cavity cleaning of 15 days, this experimenter found that oral cavity is more pure and fresh.
The test result of embodiment 2-10 is as shown in table 1.
Table 1 uses the test result of solution product and Oral cleaner
Embodiment 11
Experimenter No. 1, No. 2 and No. 5, use the solution product 1 in embodiment 1 to gargle; After half an hour, these experimenters start to use the Oral cleaner cleaning oral cavity.During cleaning, these experimenters find that there is uncomfortable sensation at some position, oral cavity, and these uncomfortable positions are exactly stomatitis speckle and stomatitis knot location.Through gargling and oral cavity cleaning in a few days, the inflammatory reaction at these positions has obtained removing.Subsequently, after gargling with above-mentioned solution, then while with Oral cleaner, carrying out oral cavity cleaning, these experimenters find in oral cavity just there is no uncomfortable sensation.Therefore,, by using above-mentioned mouthwash solution and Oral cleaner, just can effectively detect the improvement situation of oral health.
Embodiment 12
Following experimenter has only used the solution product 1 in embodiment 1 to gargle, and just finds that above-mentioned solution can slow down or remove oral ulcer.As shown in table 2, in 7 experimenters, there are 3 experimenters (10,11 and No. 12) to gargle and once just removed the misery of oral ulcer with above-mentioned solution; The misery that wherein 2 (experimenter 15 and No. 16) gargles and just remove oral ulcer 2 times; The misery that has 1 (experimenter No. 14) to gargle and just remove oral ulcer 4 times; 1 experimenter (No. 13) that has wherein gargles 8 times with above-mentioned solution, and after each the use, the symptom of oral ulcer has all obtained alleviation.
Table 2 uses separately the test result of solution product
Embodiment 13
Experimenter No. 1 and No. 2, also test solution product 2,3,4,5 and 6, and discovery solution product 2,3,4,5 and 6 also can be slowed down the oral ulcer symptom effectively.
Table 3 uses the test result of the solution product 2-6 in embodiment 1
Above-mentioned embodiment shows, adopts solution product of the present invention to gargle and can effectively slow down or remove the symptom of oral ulcer.
Embodiment 14
Research of the present invention shows, oral ulcer is to be caused by inflammatory reaction, this inflammatory reaction not only only occurs in oral cavity, also can occur in other position or the organ of health,, such as skin tends to injuredly,, if in time do not obtain medical treatment, likely can cause infection, cause inflammatory reaction, the similar ulcer of its symptom.
An experimenter (No. 17,51 years old, women) finger injuries is arranged in this research process, in time cured, the skin of finger is infected, and the symptoms such as red and swollen and pain are arranged.This experimenter cleaned the finger injuries place 30 seconds with above-mentioned solution, found that above-mentioned solution can remove the misery of pointing pain effectively, and this experimenter's wound is healed subsequently.
This shows, above-mentioned solution is conducive to remove the pain due to infected or inflammatory reaction, is conducive to the cleaning of wound, and wound healing.Above-mentioned solution product can be alleviated or the eliminate the inflammation reaction.
Instance parameter disclosed in this invention can change to some extent, but does not affect inventive concept involved in the present invention, does not therefore limit to claim involved in the present invention.
List of references:
Miller?D.R.，Lamster?I.B.，Chasens?A.I.(1984)Role?of?the?polymorphoneuclear?leukocyte?in?periodontal?health?and?disease.J?Clin?Periodontol.11：1-15.
Kantarci?A，Oyaizu?K&Van?Dyke?TE.(2003)Neutrophil-mediated?tissue?injury?in?periodontal?disease?pathogenesis：Findings?from?localized?aggressive?periodontitis.J?Periodontol.74：66-75.
Wright?D.G.，Meierovics?A.I，Foxley?J.M.(1986)Assessing?the?delivery?of?neutrophils?to?tissues?in?neutropenia.Blood.67：1023-30.
Cassatella?M.J.(2003)The?neutrophil：an?emerging?regulator?of?inflammatory?and?immune?response.Chemical?Immunology?and?Allergy，83：11-15.
Nathan?C.Neutrophils?and?Immunity：challenges?and?opportunities.Nature?Reviews?Immunology?6；173-182.
Serhan?C.N.，Savill，J.(2005)Resolution?of?inflammation：the?beginning?programs?the?end.Nat.Immunol.6：1191-1197.
Getting?S.J，Gibbs?L，Clark?A.J，Flower?R.J，Perretti?M.(1999)POMC?gene-derived?peptides?activate?melanocortin?type?3receptor?on?murine?macrophages，suppress?cytokine?release，and?inhibit?neutrophil?migration?in?acute?experimental?inflammation.J?Immunol.15；162(12)：7446-53。
Claims (13)
- One kind alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied and the solution product of the sense of taste, olfactory sensation and/or shape of face pathological changes that the stomatitis speckle brings out by stomatitis, described solution product is preferably collutory or is used for the clear scorching water that cleans a wound, it is characterized in that, described solution product comprises organic solvent, salt and the acid for stomatitis speckle in soft and delivering oral and stomatitis knot or alleviation or eliminate the inflammation reaction;Preferably, described organic solvent is selected from one or more in the agent solvent of having of ethanol, dimethyl sulfoxide and other effective and safe, described salt is selected from one or more in the salt of sodium chloride, potassium chloride and other effective and safe, and described acid is selected from one or more in the acid of ascorbic acid, citric acid and other effective and safe.
- 2. solution product as claimed in claim 1, is characterized in that, described solution product further comprises for the compound that suppresses or kill oral microorganism;Preferably, described inhibition or the compound that kills oral microorganism are: the hibitane glucose.
- 3. solution product as claimed in claim 1 or 2, is characterized in that, described solution product further comprises the compound for the taste of regulating this solution product;Preferably, the compound of described taste for regulating this solution product is: sucralose.
- 4. solution product as described in any one in claim 1-3, is characterized in that, described solution product further comprises for painted compound;Preferably, describedly for painted compound, be: phenol red sodium.
- 5. solution product as described in any one in claim 1-4, it is characterized in that, described solution product is in every liter of solution, comprise: 1-300 gram ethanol, 1-30 gram sodium chloride, 1-30 gram ascorbic acid, 0.01-1.00 gram hibitane glucose, 0.01-1.00 gram sucralose and the phenol red sodium of 0.01-0.02 gram;Preferably, described solution product, in every liter of solution, comprises 100 gram ethanol, 9 gram sodium chloride, 10 gram ascorbic acid, 0.2 gram hibitane glucose, 0.3 gram sucralose and the phenol red sodium of 0.011 gram;Preferably, described solution product, in every liter of solution, comprises 300 gram ethanol, 1 gram sodium chloride, 30 gram ascorbic acid, 1.0 gram hibitane glucoses, 0.01 gram sucralose and the phenol red sodium of 0.011 gram;Preferably, described solution product, in every liter of solution, comprises 1 gram ethanol, 30 gram sodium chloride, 1 gram ascorbic acid, 0.01 gram hibitane glucose, 1.0 gram sucralose and the phenol red sodium of 0.011 gram;Preferably, described solution product, in every liter of solution, comprises 100 gram ethanol, 9 gram sodium chloride, 10 gram citric acids, 0.2 gram hibitane glucose, 0.3 gram sucralose and the phenol red sodium of 0.011 gram;Preferably, described solution product, in every liter of solution, comprises 100 gram ethanol, 9 gram potassium chloride, 10 gram ascorbic acid, 0.2 gram hibitane glucose, 0.3 gram sucralose and the phenol red sodium of 0.011 gram;Preferably, described solution product, in every liter of solution, comprises 20 gram dimethyl sulfoxide, 9 gram sodium chloride, 10 gram ascorbic acid, 0.2 gram hibitane glucose, 0.3 gram sucralose and the phenol red sodium of 0.011 gram.
- 6. solution product as described in any one in claim 1-5, is characterized in that, described solution product is aqueous solution or glucose solution;Preferably, the concentration of glucose in described glucose solution is 0.1-15%w/v.
- One kind be used for to alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied and the combination product of the sense of taste, olfactory sensation and/or shape of face pathological changes that the stomatitis speckle brings out by stomatitis, it is characterized in that, described combination product comprises solution product as described in any one in claim 1-6.
- 8. combination product as claimed in claim 7, is characterized in that, described combination product further comprises instrument and/or the utensil at the position, place in mouth for detection of stomatitis speckle and stomatitis knot;Preferably, described instrument and/or utensil comprise: main body, cervical region and head, can tie the function part that fully contact with stomatitis speckle and stomatitis its head setting;Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and the antiinflammatory tool in one or more, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) that can carry solution or mastic, described strigil (4) covers on head (3), can fully contact with the stomatitis knot with the stomatitis speckle.
- 9. combination product as claimed in claim 7 or 8, is characterized in that, described combination product further comprises for instrument and/or the utensil of removing stomatitis speckle and stomatitis knot;Preferably, described instrument and/or utensil comprise: main body, cervical region and head, can become flexible and remove the function part of stomatitis speckle and stomatitis knot its head setting;Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and the antiinflammatory tool in one or more, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) that can carry solution or mastic, described strigil (4) covers on head (3), can fully contact with the stomatitis knot with the stomatitis speckle.
- Solution product as described in any one in claim 1-6 or as claimed in any one of claims 7-9 combination product for the preparation of alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied by stomatitis and/or the product of the sense of taste, olfactory sensation and shape of face pathological changes that the stomatitis speckle brings out in application.
- 11. one kind alleviate or remove stomatitis knot and stomatitis speckle, relative oral ulcer, periodontitis and/or halitosis, with its roughly the same inflammatory reaction or tied and the method for the sense of taste, olfactory sensation and/or shape of face pathological changes that the stomatitis speckle brings out by stomatitis, it is characterized in that, described method comprises:1) mammal such as people gargle with appropriate solution product as described in any one in claim 1-6, allow this solution product fully contact with each position in oral cavity;2) allow the active ingredient of solution product fully soften and soft stomatitis speckle and stomatitis knot;3) with instrument and/or the utensil that can detect stomatitis speckle and stomatitis knot position, place in mouth, each position of massaging oral, find uncomfortable part; Uncomfortable part is stomatitis speckle and stomatitis knot position, place;Preferably, described instrument and/or utensil comprise: main body, cervical region and head, can tie the function part that fully contact with stomatitis speckle and stomatitis its head setting;Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and the antiinflammatory tool in one or more, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) that can carry solution or mastic, described strigil (4) covers on head (3), can fully contact with the stomatitis knot with the stomatitis speckle;4) with instrument and/or the utensil that can remove stomatitis speckle and stomatitis knot, the position at massage and cleaning stomatitis speckle and stomatitis knot place;Preferably, described instrument and/or utensil comprise: main body, cervical region and head, can become flexible and remove the function part of stomatitis speckle and stomatitis knot its head setting;Preferably, described instrument and/year women utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and the antiinflammatory tool in one or more, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) that can carry solution or mastic, described strigil (4) covers on head (3), can fully contact with the stomatitis knot with the stomatitis speckle;Preferably, step 1), the time of gargling is 30 seconds; Step 2) the required time was more than 5 minutes.
- 12. a method that detects stomatitis knot and position, stomatitis speckle place, described method comprises:1) mammal such as people gargle with appropriate solution product as described in any one in claim 1-6, allow this solution product fully contact with each position in oral cavity;2) allow the active ingredient of solution product fully soften and soft stomatitis speckle and stomatitis knot;3) with instrument and/or the utensil that can detect stomatitis speckle and stomatitis knot position, place in mouth, each position of massaging oral, find uncomfortable part; Uncomfortable part is stomatitis speckle and stomatitis knot position, place;Preferably, described instrument and/or utensil comprise: main body, cervical region and head, can tie the function part that fully contact with stomatitis speckle and stomatitis its head setting;Preferably, described instrument and/or utensil comprise except scorching brush, the tool that unhitches, node-slackening brush, wash scorching brush and the antiinflammatory tool in one or more, described antiinflammatory tool comprises main body (1), cervical region (2) and head (3), and the strigil (4) that can carry solution or mastic, described strigil (4) covers on head (3), can fully contact with the stomatitis knot with the stomatitis speckle;Preferably, step 1), the time of gargling is 30 seconds; Step 2) the required time was more than 5 minutes.
- 13. one kind is detected the mammal oral health and improves the method for situation, it is characterized in that, described method comprises:Before the mammal oral health is improved and afterwards, according to claim 11, or 12 described methods detect respectively stomatitis speckle and stomatitis knot position, place in the mammal oral cavity, before then relatively improving and stomatitis speckle afterwards and stomatitis knot have a situation;Preferably, described mammal is the people.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210157498.3A CN103385802B (en) | 2012-05-11 | 2012-05-11 | Alleviate or remove the solution product of stomatitis knot and stomatitis speckle, combination product and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210157498.3A CN103385802B (en) | 2012-05-11 | 2012-05-11 | Alleviate or remove the solution product of stomatitis knot and stomatitis speckle, combination product and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103385802A true CN103385802A (en) | 2013-11-13 |
| CN103385802B CN103385802B (en) | 2016-04-13 |
Family
ID=49530337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210157498.3A Active CN103385802B (en) | 2012-05-11 | 2012-05-11 | Alleviate or remove the solution product of stomatitis knot and stomatitis speckle, combination product and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103385802B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287646A (en) * | 2014-06-07 | 2016-02-03 | 潘申权 | Solution preparation for detecting and relieving or eliminating oral inflammation, combination product and application thereof |
| WO2020015731A1 (en) * | 2018-07-20 | 2020-01-23 | 北京蔚蓝之源医药科技有限公司 | Uses of sulfoxide compound for preventing radiation-induced oral mucositis and related radiotherapy complications |
| CN115429727A (en) * | 2022-08-12 | 2022-12-06 | 上海弗艾柏生物科技有限公司 | Pet oral cavity repairing tooth cleaning water and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1316248A (en) * | 2001-03-30 | 2001-10-10 | 余隆成 | Nursing liquid for oral cavity of baby |
| CN101785710A (en) * | 2010-02-12 | 2010-07-28 | 潘申权 | Tool for clearing stomatitis spots and stomatitis nodes, and application thereof |
-
2012
- 2012-05-11 CN CN201210157498.3A patent/CN103385802B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1316248A (en) * | 2001-03-30 | 2001-10-10 | 余隆成 | Nursing liquid for oral cavity of baby |
| CN101785710A (en) * | 2010-02-12 | 2010-07-28 | 潘申权 | Tool for clearing stomatitis spots and stomatitis nodes, and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 付德明: "维生素C治疗口腔溃疡", 《家庭医学新健康》 * |
| 陈曦等: "口源性口臭的治疗", 《国外医学口腔医学分册》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287646A (en) * | 2014-06-07 | 2016-02-03 | 潘申权 | Solution preparation for detecting and relieving or eliminating oral inflammation, combination product and application thereof |
| WO2020015731A1 (en) * | 2018-07-20 | 2020-01-23 | 北京蔚蓝之源医药科技有限公司 | Uses of sulfoxide compound for preventing radiation-induced oral mucositis and related radiotherapy complications |
| CN112584866A (en) * | 2018-07-20 | 2021-03-30 | 北京蔚蓝之源医药科技有限公司 | Application of sulfoxide compound in preventing radioactive oral mucositis and related radiotherapy complications |
| CN115429727A (en) * | 2022-08-12 | 2022-12-06 | 上海弗艾柏生物科技有限公司 | Pet oral cavity repairing tooth cleaning water and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103385802B (en) | 2016-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Abidia | Oral care in the intensive care unit: a review | |
| Taiyeb-Ali et al. | Efficacy of'Gamadent'toothpaste on the healing of gingival tissues: a preliminary report | |
| Akande et al. | Efficacy of different brands of mouth rinses on oral bacterial load count in healthy adults | |
| CN104288466B (en) | A kind of medical bio fluoride in caries prevention dressing and preparation method thereof | |
| CN103385802B (en) | Alleviate or remove the solution product of stomatitis knot and stomatitis speckle, combination product and application thereof | |
| O’Connor | Oral health care | |
| Sikka et al. | Comparative anti-plaque and anti-gingivitis efficacy of two commercially available mouthwashes-4 weeks clinical study | |
| CN106176315B (en) | A kind of mouthwash and preparation method thereof | |
| RU2372949C1 (en) | Method for treating inflammatory parodentium diseases | |
| Chirkova et al. | Application of antiseptic solution for mouth cavity | |
| Basavaraj et al. | Halitosis: A review | |
| RU2565839C1 (en) | Method of treating chronic generalised catarrhal gingivitis | |
| Shukhratovich et al. | Dental Diseases And Their Development | |
| Azevedo et al. | Prevalence of prosthetic stomatitis and risk factors in a sample of institutionalized elderly | |
| Holman et al. | Promoting oral hygiene. | |
| RU2519100C1 (en) | Method of treating hypertrophic gingivitis | |
| RU2809168C1 (en) | Method of preventing peri-implantitis at the surgical stage of dental implantation of single dentition defects in the area of molars and premolars | |
| Talpur et al. | Assessment of Tongue Scraper and Using Baking Soda Mouth Wash in Reduction of Halitosis: Halitosis Reduction by Mouthwash | |
| RU2396966C1 (en) | Method of treating periodontitis | |
| Maksymenko et al. | MAIN FEATURES OF CHRONIC CATARRHAL GINGIVITIS PATHOGENETIC TREATMENT IN CHILDREN WITH OTORHINOLARYNGOLOGICAL DISEASES | |
| Строченко et al. | CURRENT TRENDS IN PERIODONTITIS TREATMENT AND PREVENTION: A LITERATURE OVERVIEW | |
| Dutonde et al. | ORAL HEALTH AND AYURVEDA: AN OVERVIEW | |
| TW202322848A (en) | The use of bromelain in cleaning tongue coating | |
| Hikmatuloyevna et al. | ORAL MUCOSA INJURIES | |
| Semenov et al. | State of oral hygiene and ways to improve it |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190711 Address after: 528200 Guangdong Province Foshan Nanhai District Shishan Town 321 National Road Xianxi Section Guangdong Biomedical Industry Base Phase I Group B Building 1102-2 Patentee after: Guangdong Jianbo Biotechnology Co., Ltd. Address before: 100096 No. 1405, 12th floor, Yuxin Garden, Xisanqi, Haidian District, Beijing Patentee before: Pan Shenquan |
|
| TR01 | Transfer of patent right |