CN105287636A - Biological snake powder composition for treating autoimmune diseases - Google Patents
Biological snake powder composition for treating autoimmune diseases Download PDFInfo
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- CN105287636A CN105287636A CN201510718067.3A CN201510718067A CN105287636A CN 105287636 A CN105287636 A CN 105287636A CN 201510718067 A CN201510718067 A CN 201510718067A CN 105287636 A CN105287636 A CN 105287636A
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Abstract
The invention discloses a biological snake powder composition for treating autoimmune diseases and a preparing method thereof. A biological fermentation technology is used for treating snake powder, the snake powder and other kinds of traditional Chinese medicine cheap relatively are compounded to obtain the biological snake powder composition, the proportion of the snake powder is greatly reduced, on the condition of greatly reducing cost, the biological snake powder composition keeps the autoimmune disease treating effect as good as that of a composition with high content of the snake powder. The biological snake powder composition has no side effects and is capable of adjusting autoimmunity, maintaining beauty, keeping young and delaying ageing, low in price and suitable for people of all ages and both sexes to take for a long time to protect health.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of biological snake powder composition and method of making the same for the treatment of autoimmune disease.
Background technology
Gout is also known as " hyperuricemia ", and disorders of purine metabolism, belongs to arthritis one.Gout is that the metabolism of the material of purine in human body gets muddled, the synthesis of uric acid increases or discharges and reduces, and causes hyperuricemia, when serum Uric Acid Concentration is too high, uric acid is deposited in joint, cartilage and kidney with the form of sodium salt, causes and organizes foreign body inflammatory reaction.Multiple partes corporis humani position, joint has an intense pain, " bitterly " overwhelmed with sorrow, and within very fast 1-7 days, pain has been blown over, so cry " gout " as " wind ".40+ male's multiple (95%), women is generally common at post menopausal, because estrogen is formed with inhibitory action to uric acid; But outbreak ratio can be increased after climacteric.The generation of hyperuricemia and gout is without direct relation, and just metabolic arthritis has the possibility of higher generation gout, needs active treatment, prevents tophaceous formation.
Motherland's medical science has more rich record to Serpentis class treatment rheumatoid arthritis, and side effect is little compared with Western medicine, can long-term taking, but onset is slow, needs patient's patience to coordinate; Adopt Chinese and Western better in conjunction with effect, Western medicine is rapid-action, energy rapid recovery patient suffering, then nurses one's health for a long time with Chinese medicine, should be desirable therapeutic scheme, but need research further.At present also mainly Agkistrodon, Zaocys and sea snake in the application of Serpentis class, other Serpentis classes use less, but in fact whole Serpentis class is all precious resources, all has good medical value, is worth further investigation exploitation.Serpentis class and toxin thereof are used for the treatment of rheumatoid arthritis and receive better effects, but also do not illustrate its mechanism of action.Snake powder is to treatment autoimmune disease, especially remarkable to the curative effect of disease such as rheumatoid arthritis, ankylosing spondylitis, and prior art has disclosed the application that some snake powder and compound thereof are used for the treatment of autoimmune disease.But snake powder price is very expensive, be not that general patient can bear and long-term taking.
The present inventor is by research and a large amount of experiments, surprisingly find to utilize biofermentation technique process snake powder, other relatively inexpensive Chinese medicines composite obtain biological snake powder compositions, under specific formula and ratio, have the effect of the treatment autoimmune disease high not second to snake powder content.
Summary of the invention
Object of the present invention can be achieved through the following technical solutions:
The object of the present invention is to provide a kind of biological snake powder compositions for the treatment of autoimmune disease, utilize biofermentation technique process snake powder, other relatively inexpensive Chinese medicines composite obtain biological snake powder compositions, under specific formula and ratio, there is the effect of the treatment autoimmune disease high not second to snake powder content, in addition, can also looks improving and the skin nourishing, slow down aging.
Technical scheme of the present invention is as follows:
Treat a biological snake powder compositions for autoimmune disease, be prepared from by the following method:
(1) by Agkistrodon halys, Zaocys through 60 DEG C of cold drying, moisture Control is within 4%;
(2) get 2 portions of Agkistrodon halyss, 3-4 part Zaocys is put into pulverizer respectively and pulverized, cross 200 mesh sieves, obtain mixing snake powder;
(3) get 10-12 part Radix Angelicae Sinensis, 1 portion of Radix Glycyrrhizae, 2-3 part sea coconut, 1 portion of CitrusaurantiumL.Var.amara Engl., dry below 60 DEG C, grind to form end, cross 100 mesh sieves, obtain mixed powder;
(4) by 1-1.2 part mixing snake powder and the mixing of 50-55 part mixed powder, carry out radiation sterilization, then sterile purified water moistening is sprayed into, according to the ratio access compound probiotic of inoculum concentration 1%, after stirring gently, at 38 DEG C of bottom fermentation 12-18 hour, through 60 DEG C of cold drying, moisture Control is within 4%;
Described probiotic bacteria is according to bacterial strain quantitative proportion, lactobacillus: bacillus subtilis: Bacillus licheniformis: bacillus bifidus is: the mixing probiotic bacteria of the ratio mixing of 1:0.6:0.2:0.5;
(5) carry out being packaged into bag according to specification.
Agkistrodon halys: carry according to Compendium of Material Medica: Agkistrodon halys is dispeled the wind counteracting toxic substances analgesia effect such as strong, can control strong wind and all aversion to wind, malignant boil scrofula, skin insensitive impediment, half body is withered, the heavy disease of brothers' internal organs.Dermis Agkistrodon halys treatment furuncle is swollen, malignant boil, bone tumor.Agkistrodon halys is dry timid wind, analgesia, removing toxic substances, tonification, stimulating milk secretion.Dispelling the wind and dampness pathogens arthralgia pain, leprosy, tuberculous lymphadenitis, furuncle, after being ill weakness, hyperhidrosis, neurasthenia, hypogalactia etc.
Agkistrodon halys be Ministry of Public Health within 2002, specify in file be food and one of kind on the article list of medicine, this list is safety according to Chinese crude drug, stability, reliability are formulated together not only can do medical material and be used as medicine, but also can be used as the edible Chinese crude drug catalogue of bread and cheese.
Zaocys: carry according to essentials of Matea Medica: " the same Agkistrodon of function, and property is apt to nontoxic.Cure mainly curing rheumatism." " herbal classic detailed outline " year: " cure mainly all wind insensitive impediment, munbness, wind scabies urticaria ， Jie Xian.Zaocys sweet in the mouth, property is put down, nontoxic." Zaocys skin cures mainly pathogenic wind toxic gas, nebula of looking unfamiliar, lockjaw lip boil.
Zaocys be Ministry of Public Health within 2002, specify in file be food and one of kind on the article list of medicine, this list is safety according to Chinese crude drug, stability, reliability are formulated together not only can do medical material and be used as medicine, but also can be used as the edible Chinese crude drug catalogue of bread and cheese.
Zaocys not only has effect of timid wind analgesia, can also relax contracture that nerve causes, numbness, to the good action of neurological functional recovery.
The present invention is on the basis of snake powder, utilize biofermentation technique process snake powder, other relatively inexpensive Chinese medicines composite obtain biological snake powder compositions, under specific formula and ratio, there is the effect of the treatment autoimmune disease high not second to snake powder content, in addition, can also looks improving and the skin nourishing, slow down aging.
Usefulness of the present invention is:
(1) the present invention utilizes biofermentation technique process snake powder, other relatively inexpensive Chinese medicines composite obtain biological snake powder compositions, greatly reduce at snake powder proportion, when cost reduces greatly, remain the effect of the treatment autoimmune disease high not second to snake powder content.
(2) biological snake powder compositions of the present invention is without any side effects, can also regulate autoimmunity, can also looks improving and the skin nourishing, slow down aging, and cheap, is applicable to men and women, old and young's long-term care and takes.
Detailed description of the invention
Embodiment 1:
The biological snake powder compositions for the treatment of autoimmune disease, is prepared from by the following method:
(1) by Agkistrodon halys, Zaocys through 60 DEG C of cold drying, moisture Control is within 4%;
(2) get 2 portions of Agkistrodon halyss, 3 parts of Zaocyss are put into pulverizer respectively and pulverized, cross 200 mesh sieves, obtain mixing snake powder;
(3) get 12 parts of Radix Angelicae Sinensis, 1 portion of Radix Glycyrrhizae, 2 portions of sea coconut, 1 portion of CitrusaurantiumL.Var.amara Engl., dry below 60 DEG C, grind to form end, cross 100 mesh sieves, obtain mixed powder;
(4) by 1.2 parts of mixing snake powder and 50 parts of mixed powder mixings, carry out radiation sterilization, then sterile purified water moistening is sprayed into, according to the ratio access compound probiotic of inoculum concentration 1%, after stirring gently, 38 DEG C of bottom fermentations 18 hours, through 60 DEG C of cold drying, moisture Control was within 4%;
Described probiotic bacteria is according to bacterial strain quantitative proportion, lactobacillus: bacillus subtilis: Bacillus licheniformis: bacillus bifidus is: the mixing probiotic bacteria of the ratio mixing of 1:0.6:0.2:0.5;
(5) carry out being packaged into bag according to specification.
Embodiment 2:
The biological snake powder compositions for the treatment of autoimmune disease, is prepared from by the following method:
(1) by Agkistrodon halys, Zaocys through 60 DEG C of cold drying, moisture Control is within 4%;
(2) get 2 portions of Agkistrodon halyss, 4 parts of Zaocyss are put into pulverizer respectively and pulverized, cross 200 mesh sieves, obtain mixing snake powder;
(3) get 10 parts of Radix Angelicae Sinensis, 1 portion of Radix Glycyrrhizae, 3 portions of sea coconut, 1 portion of CitrusaurantiumL.Var.amara Engl., dry below 60 DEG C, grind to form end, cross 100 mesh sieves, obtain mixed powder;
(4) by 1 part of mixing snake powder and 55 parts of mixed powder mixings, carry out radiation sterilization, then spray into sterile purified water moistening, according to the ratio access compound probiotic of inoculum concentration 1%, after stirring gently, 38 DEG C of bottom fermentations 12 hours, through 60 DEG C of cold drying, moisture Control is within 4%;
Described probiotic bacteria is according to bacterial strain quantitative proportion, lactobacillus: bacillus subtilis: Bacillus licheniformis: bacillus bifidus is: the mixing probiotic bacteria of the ratio mixing of 1:0.6:0.2:0.5;
(5) carry out being packaged into bag according to specification.
Embodiment 3:
The biological snake powder compositions for the treatment of autoimmune disease, is prepared from by the following method:
(1) by Agkistrodon halys, Zaocys through 60 DEG C of cold drying, moisture Control is within 4%;
(2) get 2 portions of Agkistrodon halyss, 3 parts of Zaocyss are put into pulverizer respectively and pulverized, cross 200 mesh sieves, obtain mixing snake powder;
(3) get 11 parts of Radix Angelicae Sinensis, 1 portion of Radix Glycyrrhizae, 2 portions of sea coconut, 1 portion of CitrusaurantiumL.Var.amara Engl., dry below 60 DEG C, grind to form end, cross 100 mesh sieves, obtain mixed powder;
(4) by 1.1 parts of mixing snake powder and 53 parts of mixed powder mixings, carry out radiation sterilization, then sterile purified water moistening is sprayed into, according to the ratio access compound probiotic of inoculum concentration 1%, after stirring gently, 38 DEG C of bottom fermentations 17 hours, through 60 DEG C of cold drying, moisture Control was within 4%;
Described probiotic bacteria is according to bacterial strain quantitative proportion, lactobacillus: bacillus subtilis: Bacillus licheniformis: bacillus bifidus is: the mixing probiotic bacteria of the ratio mixing of 1:0.6:0.2:0.5;
(5) carry out being packaged into bag according to specification.
Embodiment 4:
The biological snake powder compositions for the treatment of autoimmune disease, is prepared from by the following method:
(1) by Agkistrodon halys, Zaocys through 60 DEG C of cold drying, moisture Control is within 4%;
(2) get 2 portions of Agkistrodon halyss, 4 parts of Zaocyss are put into pulverizer respectively and pulverized, cross 200 mesh sieves, obtain mixing snake powder;
(3) get 12 parts of Radix Angelicae Sinensis, 1 portion of Radix Glycyrrhizae, 3 portions of sea coconut, 1 portion of CitrusaurantiumL.Var.amara Engl., dry below 60 DEG C, grind to form end, cross 100 mesh sieves, obtain mixed powder;
(4) by 1.2 parts of mixing snake powder and 51 parts of mixed powder mixings, carry out radiation sterilization, then sterile purified water moistening is sprayed into, according to the ratio access compound probiotic of inoculum concentration 1%, after stirring gently, 38 DEG C of bottom fermentations 13 hours, through 60 DEG C of cold drying, moisture Control was within 4%;
Described probiotic bacteria is according to bacterial strain quantitative proportion, lactobacillus: bacillus subtilis: Bacillus licheniformis: bacillus bifidus is: the mixing probiotic bacteria of the ratio mixing of 1:0.6:0.2:0.5;
(5) carry out being packaged into bag according to specification.
Embodiment 5:
Comparative example, do not carry out fermentation process:
The biological snake powder compositions for the treatment of autoimmune disease, is prepared from by the following method:
(1) by Agkistrodon halys, Zaocys through 60 DEG C of cold drying, moisture Control is within 4%;
(2) get 2 portions of Agkistrodon halyss, 3 parts of Zaocyss are put into pulverizer respectively and pulverized, cross 200 mesh sieves, obtain mixing snake powder;
(3) get 10 parts of Radix Angelicae Sinensis, 1 portion of Radix Glycyrrhizae, 2 portions of sea coconut, 1 portion of CitrusaurantiumL.Var.amara Engl., dry below 60 DEG C, grind to form end, cross 100 mesh sieves, obtain mixed powder;
(4) by 1 part of mixing snake powder and 52 parts of mixed powder mixings, radiation sterilization is carried out;
(5) carry out being packaged into bag according to specification.
Embodiment 6:
Comparative example, do not carry out complex treatment:
The biological snake powder compositions for the treatment of autoimmune disease, is prepared from by the following method:
(1) by Agkistrodon halys, Zaocys through 60 DEG C of cold drying, moisture Control is within 4%;
(2) get 2 portions of Agkistrodon halyss, 4 parts of Zaocyss are put into pulverizer respectively and pulverized, cross 200 mesh sieves, obtain mixing snake powder;
(3) starch is got as blank powder;
(4) by 1.2 parts of mixing snake powder and 54 parts of blank powder mixings, carry out radiation sterilization, then sterile purified water moistening is sprayed into, according to the ratio access compound probiotic of inoculum concentration 1%, after stirring gently, 38 DEG C of bottom fermentations 14 hours, through 60 DEG C of cold drying, moisture Control was within 4%;
Described probiotic bacteria is according to bacterial strain quantitative proportion, lactobacillus: bacillus subtilis: Bacillus licheniformis: bacillus bifidus is: the mixing probiotic bacteria of the ratio mixing of 1:0.6:0.2:0.5;
(5) carry out being packaged into bag according to specification.
Embodiment 7: effect is tested and assessed
(1) rheumatoid arthritis test and appraisal:
Selection is diagnosed as rheumatoid arthritis patients 120 example, is divided into treatment group 6 groups at random, often organizes 20 people, without significant difference between each group.
Diagnostic criteria: be able to unanimously for making the diagnostic criteria of rheumatoid arthritis, Americanism damp disease association worked out the criteria for classification of primary disease in 1958, and revised in 1987, now criteria for classification in 1987 is summarized as follows: 1. refuse to budge morning continuous at least 1h (every day), the course of disease at least 6 week; 2. the swollen joint of more than 3 or 3 is had, at least 6 weeks; 3. wrist, palm or phalanx, nearly articulations digitorum manus swollen at least 6 weeks; 4. subcutaneous nodule is had; 5. hands X-ray film changes (having the narrow of osteoporosis and joint space at least); 6. serum rheumatoid factor (SRF) content raises.4 persons in above-mentioned 7 are had to be diagnosed as rheumatoid arthritis.
Criterion of therapeutical effect: with reference to general criterion of therapeutical effect, 4 kinds of subjective and objective situations such as symptomes complice, chemical examination, long-term steroid, life and work ability and working out.Effective: clinical symptom disappearance, chemical examination erythrocyte sedimentation rate, mucin are all normal, formerly take hormone person withdraws, from be unable to leave the bed or live can not physiology to resuming work; Effective: clinical symptom disappearance or substantially disappear, erythrocyte sedimentation rate, mucin have and decline by a relatively large margin, or close to normal, formerly take the obvious decrement of hormone, or only take maintenance dose (less than 1), from being unable to leave the bed or can't take care of oneself to life of can taking care of oneself, maybe can do light work, comprise effective patient; Invalid: above four all without improvement or aggravation.
Give every day potion, each 5 grams of biological snake powder compositionss of the present invention are taken, and 10 days is a course for the treatment of, takes 3 courses for the treatment of, and record result, stops using and follow up a case by regular visits to after 3 months and again record result.Result is as shown in table 1.
Table 1
As can be seen here, biological snake powder compositions of the present invention is very high to the cure rate of gout, instant effect, and efficiency is high, and successful is better than comparative examples, especially the biological snake powder compositions of embodiment 4, and obvious effective rate reaches 100%.
(2) autoimmune disease measure of merit is treated:
Gout is also known as " hyperuricemia ", and disorders of purine metabolism, belongs to arthritis one.Gout is that the metabolism of the material of purine in human body gets muddled, the synthesis of uric acid increases or discharges and reduces, and causes hyperuricemia, when serum Uric Acid Concentration is too high, uric acid is deposited in joint, cartilage and kidney with the form of sodium salt, causes and organizes foreign body inflammatory reaction.Multiple partes corporis humani position, joint has an intense pain, " bitterly " overwhelmed with sorrow, and within very fast 1-7 days, pain has been blown over, so cry " gout " as " wind ".40+ male's multiple (95%), women is generally common at post menopausal, because estrogen is formed with inhibitory action to uric acid; But outbreak ratio can be increased after climacteric.The generation of hyperuricemia and gout is without direct relation, and just metabolic arthritis has the possibility of higher generation gout, needs active treatment, prevents tophaceous formation.
Select patient 120 example being diagnosed as gout, be divided into treatment group 6 groups at random, often organize 20 people, without significant difference between each group.
Therapeutic Method: take biological snake powder compositions 1 gram of the present invention, every day 3 times, 10 days is a course for the treatment of, takes 3 courses for the treatment of.
Criterion of therapeutical effect: (1) is effective: arthralgia obviously alleviates, walk lamely and disappear, joint motion freely.(2) effective: arthralgia disappears, and activity freely.(3) invalid: without significant change person.
Result is as shown in table 2.
Table 2
(3) ankylosing spondylitis is treated:
The disease that ankylosing spondylitis (AS) is is cardinal symptom with sacroiliac joint and spinal column attachment point inflammation.With HLA-B27 in associating by force.Certain micro-organisms (as klebsiella bacillus) and susceptible person autologous tissue have common antigen, can exception throw immunne response.The large joints of extremity, and annulus fibrosus disci intervertebralis and neighbouring connective fiberization thereof and ossified, and ankylosis is the chronic inflammatory disease of lesion characteristic.Ankylosing spondylitis belongs to rheumatism category, is the one of seronegative spondyloanthropathy.This cause of disease is still not clear, and is take spinal column as the chronic disease at major lesions position, involves sacroiliac joint, cause rigid spine and fibrosis, cause eye, lung, muscle, skeleton pathological changes in various degree, belong to autoimmune disease.
Select patient 120 example being diagnosed as ankylosing spondylitis, be divided into treatment group 6 groups at random, often organize 20 people, without significant difference between each group.
Therapeutic Method: take biological snake powder compositions 1 gram of the present invention, every day 3 times, 10 days is a course for the treatment of, takes 3 courses for the treatment of.
Criterion of therapeutical effect: (1) is effective: symptom disappears substantially.(2) effective: symptom alleviates.(3) invalid: without significant change person.
Result is as shown in table 3.
Table 3
Visible, the biological snake powder compositions that the present invention obtains, can significantly reduce costs, when snake powder content is low, and effectively treatment various autoimmune disease, particularly rheumatoid arthritis, gout, mandatory spondylitis.In addition, can also slow down aging, beauty treatment.
In addition, biological snake powder compositions natural health of the present invention, without any side effects, price is cheap again, is applicable to long-term taking, has boundless market prospect.
The above; be only the present invention's preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (2)
1. treat a biological snake powder compositions for autoimmune disease, be prepared from by the following method:
(1) by Agkistrodon halys, Zaocys through 60 DEG C of cold drying, moisture Control is within 4%;
(2) get 2 portions of Agkistrodon halyss, 3-4 part Zaocys is put into pulverizer respectively and pulverized, cross 200 mesh sieves, obtain mixing snake powder;
(3) get 10-12 part Radix Angelicae Sinensis, 1 portion of Radix Glycyrrhizae, 2-3 part sea coconut, 1 portion of CitrusaurantiumL.Var.amara Engl., dry below 60 DEG C, grind to form end, cross 100 mesh sieves, obtain mixed powder;
(4) by 1-1.2 part mixing snake powder and the mixing of 50-55 part mixed powder, carry out radiation sterilization, then sterile purified water moistening is sprayed into, according to the ratio access compound probiotic of inoculum concentration 1%, after stirring gently, at 38 DEG C of bottom fermentation 12-18 hour, through 60 DEG C of cold drying, moisture Control is within 4%;
Described probiotic bacteria is according to bacterial strain quantitative proportion, lactobacillus: bacillus subtilis: Bacillus licheniformis: bacillus bifidus is: the mixing probiotic bacteria of the ratio mixing of 1:0.6:0.2:0.5;
(5) carry out being packaged into bag according to specification.
2. the biological snake powder compositions for the treatment of autoimmune disease according to claim 1, is characterized in that:
(1) by Agkistrodon halys, Zaocys through 60 DEG C of cold drying, moisture Control is within 4%;
(2) get 2 portions of Agkistrodon halyss, 4 parts of Zaocyss are put into pulverizer respectively and pulverized, cross 200 mesh sieves, obtain mixing snake powder;
(3) get 12 parts of Radix Angelicae Sinensis, 1 portion of Radix Glycyrrhizae, 3 portions of sea coconut, 1 portion of CitrusaurantiumL.Var.amara Engl., dry below 60 DEG C, grind to form end, cross 100 mesh sieves, obtain mixed powder;
(4) by 1.2 parts of mixing snake powder and 51 parts of mixed powder mixings, carry out radiation sterilization, then spray into sterile purified water moistening, according to the ratio access compound probiotic of inoculum concentration 1%, after stirring gently, 38 DEG C of bottom fermentations 13 hours, through 60 DEG C of cold drying, moisture Control is within 4%;
Described probiotic bacteria is according to bacterial strain quantitative proportion, lactobacillus: bacillus subtilis: Bacillus licheniformis: bacillus bifidus is: the mixing probiotic bacteria of the ratio mixing of 1:0.6:0.2:0.5;
(5) carry out being packaged into bag according to specification.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406688A (en) * | 2008-11-28 | 2009-04-15 | 魏玉玲 | Compound formulation for treating rheumatic arthritis and rheumatoid arthritis |
| CN104758404A (en) * | 2015-03-19 | 2015-07-08 | 德清县莫干山蛇类实业有限公司 | Three-snake powder composition for treating autoimmune diseases, and preparation method thereof |
-
2015
- 2015-10-29 CN CN201510718067.3A patent/CN105287636A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406688A (en) * | 2008-11-28 | 2009-04-15 | 魏玉玲 | Compound formulation for treating rheumatic arthritis and rheumatoid arthritis |
| CN104758404A (en) * | 2015-03-19 | 2015-07-08 | 德清县莫干山蛇类实业有限公司 | Three-snake powder composition for treating autoimmune diseases, and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘骁: "蛇类药物在临床中的应用近况", 《中医药研究》 * |
| 褚新红等: "益生菌在中药开发中的应用", 《2014年中国药学大会暨第十四届中国药师周论文集》 * |
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