CN105286818B - A kind of expansionary kit of auxiliary judgment sub-health population arteria brachialis - Google Patents
A kind of expansionary kit of auxiliary judgment sub-health population arteria brachialis Download PDFInfo
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Abstract
The invention discloses a kind of expansionary kits of auxiliary judgment sub-health population arteria brachialis.It includes parameter acquisition equipment and readable carrier；The parameter acquisition equipment includes the equipment of the parameters involved in the acquisition readable carrier；The content such as following formula I, arteria brachialis dilatancy=10.826+0.232 × f (gender)+0.368 × f (age1)+0.042 × f (age2) 0.018 × f (bmi) 0.201 × f (waist2bmi) 0.023 × f (sbp) 0.020 × f (sbp dpb) formula I are described on the readability carrier.Using the kit of the present invention, there is the risk of dysfunction in the arteria brachialis dilatancy for capableing of auxiliary judgment sub-health population (30~69 years old).
Description
Technical field
The present invention relates to a kind of expansionary kits of auxiliary judgment sub-health population arteria brachialis, belong to biologic medical neck
Domain.
Background technology
Early in the 1980s, the World Health Organization (WHO) proposed in its work report one it is more novel
Health definition：Health refers not only to the intact shape in no disease or not weak or a kind of body, spirit and social adaptation
State.Although the definition of current more unauthoritative inferior health, a kind of common-sense viewpoint that people generally accept at present is just
It is the new concept of health based on above-mentioned WHO, that is, thinks that so-called inferior health refers to a kind of boundary between complete health and disease
Intermediate state.The it is proposed of inferior health idea has highly important medical value and clinical meaning, because it can promote disease
" critical point " Forward of the prevention and treatment of disease.It should be pointed out that theory of medicine of this new inferior health idea early in Ancient Times in China
In just have specific discussion, wherein a kind of viewpoint generally accepted is " above curing the disease preventiveed treatment of disease ".
With advancing age, the function and structure of human vas all can gradually change.In terms of vascular function
Variation is mainly reflected in vascular stiffness increase, elasticity reduces, arterial pulse wave conduction of velocity is speeded, vascular compliance reduces,
Distensibility of blood vessel reduces or vascular resistence is increased.The change of these vascular functions occurs often in before blood vessel structure change, but
It is this change and is usually reversible, can be improved to a certain extent by the mode of making the life better, control underlying diseases etc.
Vascular function.Therefore, vascular function can be as a Testing index of sub-health population, to find the change of vascular function as early as possible
Change, convenient for providing medicine suggestion to sub-health population.
Clinically there are many methods of detection vascular function at present, but are required for through certain specific instrument to observation pair
As being detected, and usually these instruments are all more heavy or progress network analysis is needed to obtain data, such as pulse transit
The detection of speed needs to be detected specific arteriopalmus point, and certain technology is needed to require；And the detection of ankle brachial index
Need special instrument；Systemic blood vessels compliance, systemic vascular resistance or blood vessel dilatation degree are then needed to arterial pulse wave waveform
Carrying out complicated specialty analysis calculating can draw a conclusion.The above is all not suitable for using it for larger range of base doctor
Treat practice.It is badly in need of a kind of method calculating vascular function using the existing information fast of observation object at present.
Invention content
The object of the present invention is to provide a kind of expansionary kits of auxiliary judgment sub-health population arteria brachialis, utilize this hair
There is the risk of dysfunction in bright kit, the arteria brachialis dilatancy for capableing of auxiliary judgment sub-health population (30~69 years old).
The expansionary kit of auxiliary judgment sub-health population arteria brachialis provided by the present invention comprising parameter acquisition is set
Standby and readable carrier；
The parameter acquisition equipment includes the equipment of the parameters involved in the acquisition readable carrier；
The content such as following formula I is described on the readability carrier,
Arteria brachialis dilatancy=10.826+0.232 × f (gender)+0.368 × f (age1)+0.042 × f (age2)-
0.018 × f (bmi) -0.201 × f (waist2bmi) -0.023 × f (sbp) -0.020 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, when tester is women, f (gender)
Value be 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, is 45~69 years old when the age of tester
When, the value of f (age1) is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates abdominal circumference body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg.
Above-mentioned kit, the parameter acquisition equipment includes batheroom scale, gage and sphygmomanometer, for collecting test person's
Weight, waistline, systolic pressure and diastolic pressure.
Above-mentioned kit, the readability carrier is kit specification；The print matter of the formula I on card,
Using more convenient.
Above-mentioned kit, the readability carrier is computer readable carrier.
The present invention also provides a kind of expansionary suits of auxiliary judgment sub-health population arteria brachialis comprising measured body weight
Equipment, waistline measuring apparatus, blood pressure measurement device and the computing device for being provided with parameter computing module；The parameter computing module
It can carry out the operation such as following formula I：
Arteria brachialis dilatancy=10.826+0.232 × f (gender)+0.368 × f (age1)+0.042 × f (age2)-
0.018 × f (bmi) -0.201 × f (waist2bmi) -0.023 × f (sbp) -0.020 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, when tester is women, f (gender)
Value be 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, is 45~69 years old when the age of tester
When, the value of f (age1) is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates abdominal circumference body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg.
The present invention also provides the application method of the above-mentioned expansionary kit of auxiliary judgment sub-health population arteria brachialis,
Include the following steps：
1) weight, waistline and the blood pressure of person to be checked are measured, and is recorded；
2) operation is carried out according to such as following formula I：
Arteria brachialis dilatancy=10.826+0.232 × f (gender)+0.368 × f (age1)+0.042 × f (age2)-
0.018 × f (bmi) -0.201 × f (waist2bmi) -0.023 × f (sbp) -0.020 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, when tester is women, f (gender)
Value be 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, is 45~69 years old when the age of tester
When, the value of f (age1) is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates abdominal circumference body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg.
The present invention also provides parameter acquisition equipment and readable carrier to prepare auxiliary judgment sub-health population arteria brachialis
Application in expansionary kit, wherein the parameter acquisition equipment includes each involved in the acquisition readable carrier
The equipment of item parameter；
The content such as following formula I is described on the readability carrier,
Arteria brachialis dilatancy=10.826+0.232 × f (gender)+0.368 × f (age1)+0.042 × f (age2)-
0.018 × f (bmi) -0.201 × f (waist2bmi) -0.023 × f (sbp) -0.020 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, when tester is women, f (gender)
Value be 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, is 45~69 years old when the age of tester
When, the value of f (age1) is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates abdominal circumference body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg.
Above-mentioned application, the parameter acquisition equipment include batheroom scale, gage and sphygmomanometer.
Above-mentioned application, the readability carrier is kit specification；The print matter of the formula I is on card.
Measured body weight equipment, waistline measuring apparatus, blood pressure measurement device and it is provided with parameter computing module in the present invention
Computing device is applied to prepare in the expansionary suit of auxiliary judgment sub-health population arteria brachialis, wherein described to be provided with parameter
The computing device of computing module can carry out the operation such as following formula I：
Arteria brachialis dilatancy=10.826+0.232 × f (gender)+0.368 × f (age1)+0.042 × f (age2)-
0.018 × f (bmi) -0.201 × f (waist2bmi) -0.023 × f (sbp) -0.020 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, when tester is women, f (gender)
Value be 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, is 45~69 years old when the age of tester
When, the value of f (age1) is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates abdominal circumference body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg.
Judgement of the kit of the present invention suitable for the vascular function of 30~69 years old sub-health population.
Sub-health population refers in the present invention：Blood pressure, blood fat, blood glucose, body mass index (body mass index, BMI)
Or a certain index of abdominal circumference is in the normal high level stage.
When carrying out the judgement of vascular function exception using kit of the present invention, pass through the parameter acquisition equipment collecting test
Weight, waistline, systolic pressure and the diastolic pressure of person, the gender of binding test person and age, utilize the formula described in readable carrier
I, the arteria brachialis dilatancy (%/mmHg) of subject can be obtained, by its with critical value when age groups, different sexes into
Row compares, and abnormal situation occurs in the arteria brachialis dilatancy that can obtain subject：As male other for 30~44 years old group, by
The arteria brachialis dilatancy power of examination person be more than 5.5%/mmHg when, illustrate subject there are arteria brachialis expand sexual abnormality risk, when
When women other for 30~44 years old group, when the arteria brachialis dilatancy of subject is more than 6%/mmHg, illustrating subject, there are the upper arms to move
Arteries and veins expands the risk of sexual abnormality；As male other for 45~54 years old group, the arteria brachialis dilatancy power of subject is more than 5.8%/
When mmHg, illustrating subject, there are the risks that arteria brachialis expands sexual abnormality, as women other for 45~54 years old group, subject's
When arteria brachialis dilatancy is more than 5.3%/mmHg, illustrating subject, there are the risks that arteria brachialis expands sexual abnormality；When being 55~69
When year organizes other male, when the arteria brachialis dilatancy power of subject is more than 4.9%/mmHg, illustrating subject, there are arteria brachialis expansions
The risk of extensional exception, as women other for 55~69 years old group, when the arteria brachialis dilatancy of subject is more than 5.7%/mmHg,
Illustrating subject, there are the risks that arteria brachialis expands sexual abnormality.
The expansionary kit of auxiliary judgment sub-health population arteria brachialis of the present invention, has the following advantages that：
1, by data such as weight, waistline and the blood pressures for being easy to obtain in clinic, directly whether arteria brachialis dilatancy is calculated
There are exception, is conducive to basic health mechanism medical worker and carries out that arteria brachialis is expansionary tentatively to be sentenced to medical sub-health population
It is disconnected.
2, the formula I in the present invention can utilize the form of readable carrier (software), final to realize the basic ginseng of user's input
Number (gender, age, weight, waistline and blood pressure) can be obtained arteria brachialis it is expansionary calculate as a result, simultaneously according to and critical value
Compare, to judge that arteria brachialis expands the risk of sexual abnormality, is conducive to promote this method in sub-healty adults, to the crowd of improving
Understanding to native blood vessel function and attention.
Description of the drawings
Fig. 1 is healthy group, the comparable situation of inferior health group and disease group Elastic function, and in Fig. 1, systemic blood vessels are complied with
Property unit be ml/mmHg, systemic vascular resistance unit be 103·dynes/sec/cm5, arteria brachialis dilatancy unit be %/
mmHg。
Fig. 2 is the comparable situation of general inferior health and high-risk inferior health Elastic function unnatural proportions.
Fig. 3 is the comparable situation of high-risk inferior health and general inferior health person's Elastic function, and in Fig. 3, systemic blood vessels are suitable
Answering property unit is ml/mmHg, and systemic vascular resistance unit is 103·dynes/sec/cm5, arteria brachialis dilatancy unit be %/
mmHg。
Fig. 4 is the comparable situation of different type body inferior health group blood vessel elasticity index, in Fig. 4, systemic blood vessels compliance
Unit is ml/mmHg, and systemic vascular resistance unit is 103·dynes/sec/cm5, arteria brachialis dilatancy unit is %/mmHg.
Specific implementation mode
Experimental method used in following embodiments is conventional method unless otherwise specified.
The materials, reagents and the like used in the following examples is commercially available unless otherwise specified.
One, subject's vascular function correlation analysis
1, the determination of vascular function dividing value point
The purpose of the present invention is the assessment of arterial function is carried out to inferior health patient.The present invention uses the U.S.
The capital equipment that Dynapulse200A arterial elasticities sensing equipment influences arterial elasticity as evaluation inferior health, selects system
The evaluation index of vascular compliance, systemic vascular resistance and arteria brachialis dilatancy as Elastic function.Determine Healthy People
The dividing value point of arterial function exceptional value is the basis for ensureing the present invention and being smoothed out.Only has American exceptional value dividing value at present
Point, as shown in table 2, to ensure the function of accurately evaluation artery, first according to 300 selected Healthy People blood vessel work(of the present invention
Energy data determine the evaluation point of contact of three vascular function indexs, and as the basis of vascular function of the present invention analysis.
Since age-sex has specific influence, the present invention to be grouped research object by Sex, Age vascular function, bullet
Property index is using 20% lower limit of normal person as boundary's point value, and Drag Indices are using 80% upper limit of normal person as boundary's point value, concrete numerical value
It is shown in Table 1.
The dividing value point of 1 three elastic indexs of age groups of the present invention of table
2 American population vascular function dividing value point of table
2, Body health, body inferior health and sick people's Elastic function data analysis
(1) classified data is analyzed：Blood vessel elasticity index is divided into Critical anomaly and normal two according to the dividing value of above-mentioned determination
Group is compared in different crowd.Using contingency table Chi-square Test, the normal and unnatural proportions of three groups of blood vessel elasticity indexs are shown in
Table 3, difference still reaches statistical significance after calibrated age-sex.Further compare two-by-two, it is healthy compared with inferior health group, SVC,
The P values of SVR and BAD are respectively 0.0452,0.6420 and 0.0005；Healthy group compared with disease group, P values are respectively<0.0001,
0.0079 and 0.0001；Inferior health P values compared with disease group are respectively 0.0072,0.0092 and 0.4389.
The different group blood vessel elasticity Indexes Abnormality situations of table 3 compare (n=1297)
(2) measurement data is analyzed：The measurement mean value and standard deviation of three kinds of blood vessel elasticity indexs of each group are shown in Table 4.Using variance
The difference of blood vessel elasticity index between each group is compared in analysis, and difference still reaches statistical significance after calibrated age-sex.Further two
Two compare：Systemic blood vessels comply with sex-health compared with inferior health group, P<0.0001, health group is compared with disease group, P=
0.0046, inferior health group is compared with disease group, P=0.0020.Systemic vascular resistance inferior health, disease group are compared with healthy group, P
Value is respectively 0.0377 and 0.0442, and inferior health and disease group comparing difference are not statistically significant.
The different group blood vessel elasticity Indexes Comparisons of table 4
As seen from Figure 1, with the difference of health status：Health, inferior health, disease, systemic blood vessels compliance (SVC)
It is continuously decreasing, systemic vascular resistance (SVR) gradually increases, and arteria brachialis dilatancy (BAD) gradually declines.
3, different degrees of and different type body inferior health Elastic function analysis
(1) comparative analysis of general inferior health and high-risk inferior health patient vessel spring function：Systemic blood vessels compliance is different
Often or arteria brachialis expansion sexual abnormality person is more than general inferior health group, two groups of systemic vascular resistance abnormal rate in high-risk inferior health group
Without significant difference.Contingency table is relatively shown in Table 5 and Fig. 2, and variance analysis is shown in Table 6.
Variance analysis shows that high-risk inferior health group system vascular compliance and arteria brachialis dilatancy are less than general inferior health
Group, difference still reaches statistically significant meaning after correcting age-sex, and the high-risk inferior health group of systemic vascular resistance is sub- higher than general
Healthy group, but difference does not reach statistically significant meaning (being shown in Table 6 and Fig. 3).
5 general inferior health of table and high-risk inferior health group blood vessel elasticity index be normal and unnatural proportions
6 general inferior health of table and high-risk inferior health group blood vessel elasticity index
As seen from Figure 3, the high-risk inferior health of 3A systemic blood vessels compliance is less than general inferior health, 3B systemic vascular resistances
High-risk inferior health is higher than inferior health, and the high-risk inferior health of 3C arteria brachialis dilatancies is less than general inferior health.
(2) comparative analysis of different type inferior health group Elastic function：
The comparative analysis of blood vessel elasticity index between seven hypotypes of body inferior health, table 7 compares for contingency table, between display group
Difference reaches statistical significance.Further comparison among groups analysis, any one of such as three indexs Indexes Abnormality are thought of as blood vessel
Dysfunction, then In Prehypertensive group and blood pressure merge raised group of phase of blood glucose or the normal high level group of blood fat and no blood pressure
Than there is the difference of statistical significance, and other comparison among groups no significant differences.Equally, systemic blood vessels compliance,
There is also this phenomenons for systemic vascular resistance comparison among groups.Arteria brachialis dilatancy is not notable in each comparison among groups difference.
Table 8 is variance analysis, equally shows that each group difference reaches statistically significant meaning.Further compare two-by-two：1. being
System vascular compliance：Simple In Prehypertensive group and blood glucose merge the normal high level group of blood fat and are less than the normal high level of simple blood fat
With the normal high level group of simple blood glucose, blood pressure merges the normal high level group of blood glucose and is less than the normal high level group of simple blood glucose, and difference reaches statistics
Learn meaning, other comparison among groups no significant differences.2. systemic vascular resistance：Simple In Prehypertensive group is higher than simple
The normal high level group of blood glucose, other comparison among groups differences do not reach statistical significance.3. arteria brachialis dilatancy：Simple blood pressure is normally high
Value and blood pressure merge blood glucose or the normal high level group of blood fat is less than the normal high level group of simple blood glucose, other comparison among groups differences are without system
Meter learns meaning (see Fig. 4).
The normal and unnatural proportions of 7 different type inferior health group Elastic function of table
The variance analysis of 8 different type inferior health group Elastic function of table
It is drawn the following conclusions by the result of study of sub-health state under above different situations：
1) only in the normal high level stage, although the vascular function of subject has received the indexs such as blood pressure, blood glucose, blood fat
It influences.Prompt：Body sub-health state will produce detrimental effect to the spring function of blood vessel.
2) blood pressure is to influence the most important factor of Elastic function, influences intensity and is higher than blood fat and blood glucose.
3) aggregation influence bigger to vascular function of a variety of cardiovascular risk factors in the normal high level stage.
4, the relationship of different physical signs and blood vessel elasticity
(1) gender, the relationship at age and blood vessel elasticity index：The difference of different sexes and age groups blood vessel elasticity index
The different statistically significant meaning of tool.Further analyze two-by-two：1. systemic blood vessels compliance：After correcting gender, each age group compares, F
It is worth=34.97, P<0.0001；Further compared two-by-two using Bonferroni methods, in 30~44 years old group and 45~54 years old group ratio
Compared with P=0.0006, for the two compared with 55~99 years old group, P values are equal<0.0001.Two gender comparisons after the correction age, P<0.0001.
2. systemic vascular resistance：After correcting gender, each age group compares, F values=17.30, P<0.0001；Using Bonferroni methods into
One step compares two-by-two, and for 30~44 years old group compared with other two groups, P values are equal<0.0001.Other two group differences do not reach statistics and anticipate
Justice, P=0.1400.Two gender comparisons after the correction age, P<0.0001.3. arteria brachialis dilatancy：After correcting gender, each age group
Compare, F values=21.36, P<0.0001；Further compared two-by-two using Bonferroni methods, 30~44 years old group with other two groups
Compare, P values are equal<0.0001.Other two group differences do not reach statistical significance, P=0.1459.Two gender comparisons after the correction age
Difference does not reach statistical significance, P=0.1943.(being shown in Table 9)
9 gender of table, the relationship at age and blood vessel elasticity index
(2) relationship of blood pressure level and blood vessel elasticity index：After correcting age-sex, different level of blood pressure subgroup blood vessel bullet
There is significant difference in property index.Further compare two-by-two, for systemic blood vessels compliance, In Prehypertensive and hypertension group
Compared with blood pressure is normally organized, P values are equal<0.0001, In Prehypertensive is compared with two groups of hypertension, P=0.0109.For system
Vascular resistence, normally group is compared with normal high level group for blood pressure, and P=0.0123, other compare two-by-two, P<0.0001.It is dynamic for the upper arm
Arteries and veins dilatancy, two groups of comparing differences of hypertension and In Prehypertensive are not statistically significant, and P=0.7109, other compare two-by-two,
P<0.0001.(being shown in Table 10)
The relationship of table 10 blood pressure level and blood vessel elasticity index
(3) relationship of obese degree and blood vessel elasticity index：Study population is being divided into body mass index just according to body mass index
Often (body mass index<24kg/m2), overweight (body mass index 24-30kg/m2) and fat (body mass index>30kg/m2) three groups, correction
After age-sex, between three groups there is significant difference in blood vessel elasticity index.Further compare two-by-two, systemic blood vessels are complied with
Property, normally group is compared with overweight group by BMI, P<0.0001, other comparison among groups differences do not reach statistical significance.For systemic blood vessels
Resistance, normally group is compared with overweight group by BMI, P<0.0001, BMI normal group is with fat group compared with, P=0.0080, overweight group and
Fat group comparing difference does not reach statistical significance.Compare two-by-two between three groups of arteria brachialis dilatancy and does not reach statistical significance.It (is shown in Table
11)
The relationship of table 11 body mass index and blood vessel elasticity index
(4) relationship of blood glucose level and blood vessel elasticity index：Either fasting blood-glucose or postprandial 2 hours blood glucose, water
The flat difference between blood vessel elasticity index does not reach statistically significant meaning.(being shown in Table 12 and table 13)
The relationship of table 12 fasting blood glucose level and blood vessel elasticity index
The relationship of table 13 postprandial 2 hours (OGTT) blood glucose levels and blood vessel elasticity index
(5) relationship of blood lipid level and blood vessel elasticity index：This research respectively consolidates low density lipoprotein cholesterol, total courage
Alcohol, total triglycerides and High-density Lipoprotein-cholesterol and blood vessel elasticity index carry out correlation analysis, and difference does not reach
Statistically significant meaning.(being shown in Table 14, table 15, table 16 and table 17)
14 low density lipoprotein cholesterol of table (LDL-C) and vascular function
15 total cholesterol of table (TC) and vascular function
16 high-density lipoprotein cholesterol of table (HDL-C) and vascular function
17 triglycerides of table (TG) and vascular function
It can be derived that by the studies above to draw a conclusion：
1) no matter masculinity femininity, with advancing age, vascular compliance decline, resistance increase；
2) same year age group, women vascular compliance are less than male, and vascular resistence is higher than male；
3) as the raising of blood pressure, vascular compliance decline, vascular resistence increases；
4) overweight and overweight people's systemic blood vessels compliance is higher than Normal-weight person, and systemic vascular resistance reduces, and reason has
It waits for further studying.
5, the relationship of inflammation index (hsCRP) and blood vessel elasticity
In recent years research finds that inflammatory reaction takes part in the development of artery sclerosis, and may partly be opened under sub-health state
Dynamic inflammatory factor, which kind of sub-health state are easy to start inflammatory factorWhat influence to vascular function isThe present invention inquires into
The above content.Using international conventional use of high-sensitive C-reactive protein (hsCRP) as the inflammation under analysis body sub-health state
Index.According to the scheme of multicenter, international large size clinical research JUPITER researchs, according to hsCRP levels<2mg/L and >=2mg/L
It is divided into two groups, it is seen that three kinds of vascular function indexs are not statistically significant (being shown in Table 18) in two group differences.
The 18 horizontal subjects of difference hsCRP of table and blood vessel elasticity Indexes Comparison
It can be derived that by the studies above to draw a conclusion：
Inflammation index is with vascular function index without significant correlation.
Two, the linear regression model (LRM) for the sub-health population that arteria brachialis dilatancy participates in
In sub-health population using vascular function index as dependent variable, with gender, age, blood pressure, blood glucose, blood lipid level, body
Weight index, abdominal circumference, hsCRP levels, Psychological assessment, Syndrome Types of TCM etc. carry out multiple linear regression analysis (specific number for independent variable
According to being shown in Table 19).
19 arteria brachialis dilatancy linear regression model (LRM) of table
*:Abdominal circumference body mass index ratio=waistline (cm)/body mass index (kg/m2)
**:Pulse pressure difference=systolic pressure (mmHg)-diastolic pressure (mmHg)
Arteria brachialis dilatancy=10.826+0.232 × f (gender)+0.368 × f (age1)+0.042 × f (age2)-
0.018 × f (bmi) -0.201 × f (waist2bmi) -0.023 × f (sbp) -0.020 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, when tester is women, f (gender)
Value be 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, is 45~69 years old when the age of tester
When, the value of f (age1) is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates abdominal circumference body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg.
The expansionary critical point of age groups arteria brachialis is as shown in table 20.
The expansionary dividing value point of 20 age groups arteria brachialis of table
Therefore using record above-mentioned model kit can auxiliary judgment sub-health population there is arteria brachialis dilatancy
Abnormal situation, the arteria brachialis dilatancy of the subject obtained according to above-mentioned model is compared with the critical point in table 20,
There is abnormal situation in the arteria brachialis dilatancy that can obtain subject：As male other for 30~44 years old group, subject's
When arteria brachialis dilatancy power is more than 5.5%/mmHg, illustrate subject there are the risk that arteria brachialis expands sexual abnormality, when for 30~
When the other women of 44 years old groups, when the arteria brachialis dilatancy of subject is more than 6%/mmHg, illustrating subject, there are arteria brachialis expansions
The risk of sexual abnormality；As male other for 45~54 years old group, when the arteria brachialis dilatancy power of subject is more than 5.8%/mmHg,
Illustrating subject, there are the risks that arteria brachialis expands sexual abnormality, as women other for 45~54 years old group, the arteria brachialis of subject
When dilatancy is more than 5.3%/mmHg, illustrating subject, there are the risks that arteria brachialis expands sexual abnormality；When for 55~69 years old group
Male when, when the arteria brachialis dilatancy power of subject is more than 4.9%/mmHg, illustrating subject, there are arteria brachialis dilatancy is different
Normal risk, as women other for 55~69 years old group, when the arteria brachialis dilatancy of subject is more than 5.7%/mmHg, illustrate by
There are the risks that arteria brachialis expands sexual abnormality by examination person.
Claims (8)
1. a kind of expansionary kit of auxiliary judgment sub-health population arteria brachialis comprising parameter acquisition equipment and readable load
Body；
The parameter acquisition equipment includes the equipment of the parameters involved in the acquisition readable carrier；
The parameter acquisition equipment includes batheroom scale, gage and sphygmomanometer；
The content such as following formula I is described on the readability carrier,
Arteria brachialis dilatancy=10.826+0.232 × f (gender)+0.368 × f (age1)+0.042 × f (age2) -0.018
× f (bmi) -0.201 × f (waist2bmi) -0.023 × f (sbp) -0.020 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, and when tester is women, f (gender's) takes
Value is 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, when the age of tester is 45~69 years old, f
(age1) value is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old or 55 when the age of tester
At~69 years old, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates abdominal circumference body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg.
2. kit according to claim 1, it is characterised in that：The readability carrier is kit specification；It is described
The print matter of formula I is on card.
3. kit according to claim 1, it is characterised in that：The readability carrier is computer readable carrier.
4. a kind of expansionary suit of auxiliary judgment sub-health population arteria brachialis comprising measured body weight equipment, waistline measurement are set
Standby, blood pressure measurement device and the computing device for being provided with parameter computing module；The parameter computing module can be carried out such as following formula I
Operation：
Arteria brachialis dilatancy=10.826+0.232 × f (gender)+0.368 × f (age1)+0.042 × f (age2) -0.018
× f (bmi) -0.201 × f (waist2bmi) -0.023 × f (sbp) -0.020 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, and when tester is women, f (gender's) takes
Value is 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, when the age of tester is 45~69 years old, f
(age1) value is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old or 55 when the age of tester
At~69 years old, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates abdominal circumference body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg.
5. the application method of any expansionary kits of auxiliary judgment sub-health population arteria brachialis of claim 1-3,
Include the following steps：
1) weight, waistline and the blood pressure of person to be checked are measured, and is recorded；
2) operation is carried out according to such as following formula I：
Arteria brachialis dilatancy=10.826+0.232 × f (gender)+0.368 × f (age1)+0.042 × f (age2) -0.018
× f (bmi) -0.201 × f (waist2bmi) -0.023 × f (sbp) -0.020 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, and when tester is women, f (gender's) takes
Value is 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, when the age of tester is 45~69 years old, f
(age1) value is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old or 55 when the age of tester
At~69 years old, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates abdominal circumference body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg.
6. parameter acquisition equipment and readable carrier are in preparing the expansionary kit of auxiliary judgment sub-health population arteria brachialis
Application, wherein the parameter acquisition equipment includes the equipment of the parameters involved in the acquisition readable carrier；It is described
Parameter acquisition equipment includes batheroom scale, gage and sphygmomanometer；
The content such as following formula I is described on the readability carrier,
Arteria brachialis dilatancy=10.826+0.232 × f (gender)+0.368 × f (age1)+0.042 × f (age2) -0.018
× f (bmi) -0.201 × f (waist2bmi) -0.023 × f (sbp) -0.020 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, and when tester is women, f (gender's) takes
Value is 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, when the age of tester is 45~69 years old, f
(age1) value is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old or 55 when the age of tester
At~69 years old, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates abdominal circumference body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg.
7. application according to claim 6, it is characterised in that：The readability carrier is kit specification；The formula I
Print matter on card.
8. measured body weight equipment, waistline measuring apparatus, blood pressure measurement device and being provided with the computing device of parameter computing module and existing
Prepare the application in the expansionary suit of auxiliary judgment sub-health population arteria brachialis, wherein described to be provided with parameter computing module
Computing device can carry out the operation such as following formula I：
Arteria brachialis dilatancy=10.826+0.232 × f (gender)+0.368 × f (age1)+0.042 × f (age2) -0.018
× f (bmi) -0.201 × f (waist2bmi) -0.023 × f (sbp) -0.020 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, and when tester is women, f (gender's) takes
Value is 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, when the age of tester is 45~69 years old, f
(age1) value is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old or 55 when the age of tester
At~69 years old, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates abdominal circumference body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg.
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| CN103536281A (en) * | 2013-10-30 | 2014-01-29 | 广东省医疗器械研究所 | Vascular endothelial function detecting device based on fingertip temperature change |
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| WO2008015761A1 (en) * | 2006-08-04 | 2008-02-07 | Shimadzu Corporation | Ultrasonograph |
| RU2496411C2 (en) * | 2008-02-27 | 2013-10-27 | Конинклейке Филипс Электроникс Н.В. | Hemodynamic monitors and devices of alarm system |
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|---|---|---|---|---|
| CN201492415U (en) * | 2009-09-04 | 2010-06-02 | 北京麦邦光电仪器有限公司 | Blood vessel health degree detection device |
| CN103536281A (en) * | 2013-10-30 | 2014-01-29 | 广东省医疗器械研究所 | Vascular endothelial function detecting device based on fingertip temperature change |
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