CN105286819B - A kind of kit of the full crowd's vascular function of auxiliary judgment - Google Patents
A kind of kit of the full crowd's vascular function of auxiliary judgment Download PDFInfo
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Abstract
The invention discloses a kind of kits of the full crowd's vascular function of auxiliary judgment.It includes parameter acquisition equipment and readable carrier；The parameter acquisition equipment includes the equipment of the parameters involved in the acquisition readable carrier；The content such as formula I and formula II is described on the readability carrier.A kind of suit of the full crowd's vascular function of auxiliary judgment comprising measured body weight equipment, waistline measuring apparatus, blood pressure measurement device and the computing device for being provided with parameter computing module；The parameter computing module can carry out the operation such as formula I and formula II.Using the present invention kit, can the full crowd of auxiliary judgment (30~69 years old) there is the risk of vascular function exception.
Description
Technical field
The present invention relates to a kind of kits of the full crowd's vascular function of auxiliary judgment, belong to biologic medical field.
Background technology
With advancing age, the function and structure of human vas all can gradually change.In terms of vascular function
Variation is mainly reflected in vascular stiffness increase, blood vessel elasticity reduces, arterial pulse wave conduction of velocity is speeded, vascular compliance drop
Low, distensibility of blood vessel reduces or vascular resistence is increased.The change of these vascular functions occurs often in before blood vessel structure change,
But this change is usually reversible again, it, can be to a certain extent by the mode of making the life better or control underlying diseases etc.
Improve vascular function.Therefore, it is necessary to the detection of vascular function be promoted in full crowd, to find the possibility of vascular function as early as possible
Variation, convenient for providing medicine suggestion to these crowds.
Clinically there are many methods of detection vascular function at present, but are required for through certain specific instrument to observation pair
As being detected, and usually these instruments are all more heavy or progress network analysis is needed to obtain data, such as pulse transit
The detection of speed needs to be detected specific arteriopalmus point, needs technology to require operator；And the detection of ankle brachial index
It is also required to special instrument；Systemic blood vessels compliance, systemic vascular resistance and blood vessel dilatation degree are then needed to arterial pulse wave wave
Shape, which carries out complicated specialty analysis calculating, to draw a conclusion.The above is all not suitable for using it for larger range of base
Medical practice.It is badly in need of a kind of method judging vascular function using the observation existing information fast of object at present.
Invention content
The object of the present invention is to provide a kind of kits of the full crowd's vascular function of auxiliary judgment, utilize the reagent of the present invention
Box, can the full crowd of auxiliary judgment (30~69 years old) there is the risk of vascular function exception.
The kit of the full crowd's vascular function of auxiliary judgment provided by the invention comprising parameter acquisition equipment and readability
Carrier；
The parameter acquisition equipment includes the equipment of the parameters involved in the acquisition readable carrier；
The content such as following formula I and formula II is described on the readability carrier,
In formula I, when tester is male, the value of f (gender) is 0, when tester is women, f (gender)
Value be 1；
When the age of tester is 45~54 years old, the value of f (age1) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age1) is 0；
When the age of tester is 55~69 years old, the value of f (age2) is 1, is 30~54 years old when the age of tester
When, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates waistline body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg；
In formula II, p indicates that the risk of vascular function exception occurs in tester.
Above-mentioned kit, the parameter acquisition equipment includes batheroom scale, gage and sphygmomanometer, for collecting test person's
Weight, waistline, systolic pressure and diastolic pressure.
Above-mentioned kit, the readability carrier can be kit specification；The print matter of the formula I and formula II exists
On card, use is more convenient.
Above-mentioned kit, the readability carrier can be computer readable carrier.
The present invention also provides the suits of the full crowd's vascular function of auxiliary judgment comprising measured body weight equipment, waistline are surveyed
Measure equipment, blood pressure measurement device and the computing device for being provided with parameter computing module；The parameter computing module can carry out such as
The operation of following formula I and formula II：
In formula I, when tester is male, the value of f (gender) is 0, when tester is women, f (gender)
Value be 1；
When the age of tester is 55~69 years old, the value of f (age2) is 1, is 30~54 years old when the age of tester
When, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates waistline body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg；
In formula II, p indicates that the risk of vascular function exception occurs in tester.
The present invention also provides the application method of the kit of the full crowd's vascular function of above-mentioned auxiliary judgment, including it is following
Step：
1) weight, waistline and the blood pressure of person to be checked are measured, and is recorded；
2) operation is carried out according to such as following formula I and formula II：
When the age of tester is 55~69 years old, the value of f (age2) is 1, is 30~54 years old when the age of tester
When, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates waistline body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg；
In formula II, p indicates that the risk of vascular function exception occurs in tester.
The present invention also provides parameter acquisition equipment and readable carrier to prepare the full crowd's vascular function of auxiliary judgment
Application in kit, wherein the parameter acquisition equipment includes the parameters involved in the acquisition readable carrier
Equipment；
The content such as following formula I and formula II is described on the readability carrier,
In formula I, when tester is male, the value of f (gender) is 0, when tester is women, f (gender)
Value be 1；
When the age of tester is 45~54 years old, the value of f (age1) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age1) is 0；
When the age of tester is 55~69 years old, the value of f (age2) is 1, is 30~54 years old when the age of tester
When, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates waistline body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg；
In formula II, p indicates that the risk of vascular function exception occurs in tester.
Above-mentioned application, the parameter acquisition equipment include batheroom scale, gage and sphygmomanometer.
Above-mentioned application, the readability carrier is kit specification；The print matter of the formula I and formula II is in card
On.
In the present invention, measured body weight equipment, waistline measuring apparatus, blood pressure measurement device and it is provided with parameter computing module
Computing device is applied to prepare the suit of auxiliary judgment full crowd's vascular function, wherein the parameter computing module that is provided with
Computing device can carry out the operation such as following formula I and formula II：
In formula I, when tester is male, the value of f (gender) is 0, when tester is women, f (gender)
Value be 1；
When the age of tester is 55~69 years old, the value of f (age2) is 1, is 30~54 years old when the age of tester
When, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates waistline body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg；
In formula II, p indicates that the risk of vascular function exception occurs in tester.
Judgement of the kit of the present invention suitable for the vascular function of 30~69 years old full crowd (population).
" full crowd " in the present invention refers to healthy population, sub-health population and sick people；Wherein, (1) Healthy People
Group refers to sub-health population without the clinical disease clarified a diagnosis, without excessive drinking or dementia；And meet the following conditions：Waistline：Male<
90cm, women<85cm, body mass index：<28kg/m2, mean blood pressure：<140/90mmHg, fasting blood-glucose：<7mmol/L.Postprandial 2
Hour blood glucose<11.1mmol/L low density lipoprotein cholesterol：＜ 4.14mmol/L, total cholesterol<6.24mmol/L highly dense
Spend lipoprotein cholesterol>=1.04mmol/L, triglycerides<2.27mmol/L high-sensitive C-reactive protein<10mg/L, third turn of ammonia of paddy
Enzyme：<80u/L, creatinine：Normally；(2) sick people refers to no excessive drinking, dementia or the clinical disease clarified a diagnosis without other, but only deposits
In a kind of following patient of disease：High blood pressure, hyperlipidemia, diabetes, coronary heart disease or cerebral apoplexy.
When carrying out the judgement of vascular function exception using kit of the present invention, pass through the parameter acquisition equipment collecting test
Weight, waistline, systolic pressure and the diastolic pressure of person, the gender of binding test person and age utilize the formula I described in readable carrier
With formula II, p value can be obtained, p value indicates that the risk of vascular function exception occurs in tester, is the number between 0~1, is 0
When, illustrate that vascular function is normal；When for from 0 to 1, p value is bigger, and illustrating tester, there are the risk of vascular function exception is bigger.
The kit of the full crowd's vascular function of auxiliary judgment of the present invention, has the following advantages that：
(1) by data such as weight, waistline and the blood pressures for being easy to obtain in clinic, directly calculate that vascular function whether there is
It is abnormal, be conducive to the preliminary judgement that basic health mechanism medical worker carries out the patient that goes to a doctor vascular function.
(2) the formula I in the present invention and formula II can be calculated using computer readable carrier (software), final real
Current family input basic parameter (gender, age, weight, waistline, systolic pressure and diastolic pressure) can be obtained p value, to judge blood
The risk of pipe dysfunction is conducive to promote this method in crowd, to the crowd of improving to the understanding of native blood vessel function with
Pay attention to.
(3) judgement of the final risk for obtaining vascular function exception of the present invention, can be to systemic blood vessels compliance, system blood
There is the judgement of abnormal risk in pipe resistance or arteria brachialis dilatancy, judged the more comprehensive of vascular function.
Description of the drawings
Fig. 1 is healthy group, the comparable situation of inferior health group and disease group Elastic function, and in Fig. 1, systemic blood vessels are complied with
Property unit be ml/mmHg, systemic vascular resistance unit be 103·dynes/sec/cm5, arteria brachialis dilatancy unit be %/
mmHg。
Fig. 2 is the comparable situation of general inferior health and high-risk inferior health Elastic function unnatural proportions.
Fig. 3 is the comparable situation of high-risk inferior health and general inferior health person's Elastic function, and in Fig. 3, systemic blood vessels are suitable
Answering property unit is ml/mmHg, and systemic vascular resistance unit is 103·dynes/sec/cm5, arteria brachialis dilatancy unit be %/
mmHg。
Fig. 4 is the comparable situation of different type body inferior health group blood vessel elasticity index, in Fig. 4, systemic blood vessels compliance
Unit is ml/mmHg, and systemic vascular resistance unit is 103·dynes/sec/cm5, arteria brachialis dilatancy unit is %/mmHg.
Specific implementation mode
Experimental method used in following embodiments is conventional method unless otherwise specified.
The materials, reagents and the like used in the following examples is commercially available unless otherwise specified.
One, subject's vascular function correlation analysis
1, the determination of vascular function dividing value point
The purpose of the present invention is to full crowd's (i.e. population：Healthy People, sub-healty adults, sick people) patient is into action
The assessment of arteries and veins function.The present invention is using 200 A arterial elasticity sensing equipments of U.S. Dynapulse as the full crowd's artery of evaluation
The capital equipment of elasticity, selects systemic blood vessels compliance, systemic vascular resistance and arteria brachialis dilatancy as Elastic function
Evaluation index.Determine that the dividing value point of the arterial function exceptional value of Healthy People is the basis for ensureing the present invention and being smoothed out.At present
Only American exceptional value dividing value point, as shown in table 2, to ensure the function of accurately evaluation artery, first according to the present invention
300 selected Healthy People vascular function data determine the evaluation point of contact of three vascular function indexs, and as blood of the present invention
The basis of pipe functional analysis.
Since age-sex has specific influence, the present invention to be grouped research object by Sex, Age vascular function, bullet
Property index is using 20% lower limit of normal person as boundary's point value, and Drag Indices are using 80% upper limit of normal person as boundary's point value, concrete numerical value
It is shown in Table 1.
The dividing value point of 1 three elastic indexs of age groups of the present invention of table
2 American population vascular function dividing value point of table
2, Body health, body inferior health and sick people's Elastic function data analysis
(1) classified data is analyzed：Blood vessel elasticity index is divided into Critical anomaly and normal two according to the dividing value of above-mentioned determination
Group is compared in different crowd.Using contingency table Chi-square Test, the normal and unnatural proportions of three groups of blood vessel elasticity indexs are shown in
Table 3, difference still reaches statistical significance after calibrated age-sex.Further compare two-by-two, it is healthy compared with inferior health group, SVC,
The P values of SVR and BAD are respectively 0.0452,0.6420 and 0.0005；Healthy group compared with disease group, P values are respectively<0.0001,
0.0079 and 0.0001；Inferior health P values compared with disease group are respectively 0.0072,0.0092 and 0.4389.
The different group blood vessel elasticity Indexes Abnormality situations of table 3 compare (n=1297)
(2) measurement data is analyzed：The measurement mean value and standard deviation of three kinds of blood vessel elasticity indexs of each group are shown in Table 4.Using variance
The difference of blood vessel elasticity index between each group is compared in analysis, and difference still reaches statistical significance after calibrated age-sex.Further two
Two compare：Systemic blood vessels comply with sex-health compared with inferior health group, P<0.0001, health group is compared with disease group, P=
0.0046, inferior health group is compared with disease group, P=0.0020.Systemic vascular resistance inferior health, disease group are compared with healthy group, P
Value is respectively 0.0377 and 0.0442, and inferior health and disease group comparing difference are not statistically significant.
The different group blood vessel elasticity Indexes Comparisons of table 4
As seen from Figure 1, with the difference of health status：Health, inferior health, disease, systemic blood vessels compliance (SVC)
It is continuously decreasing, systemic vascular resistance (SVR) gradually increases, and arteria brachialis dilatancy (BAD) gradually declines.
3, different degrees of and different type body inferior health Elastic function analysis
(1) comparative analysis of general inferior health and high-risk inferior health patient vessel spring function：Systemic blood vessels compliance is different
Often or arteria brachialis expansion sexual abnormality person is more than general inferior health group, two groups of systemic vascular resistance abnormal rate in high-risk inferior health group
Without significant difference.Contingency table is relatively shown in Table 5 and Fig. 2, and variance analysis is shown in Table 6.
Variance analysis shows that high-risk inferior health group system vascular compliance and arteria brachialis dilatancy are less than general inferior health
Group, difference still reaches statistically significant meaning after correcting age-sex, and the high-risk inferior health group of systemic vascular resistance is sub- higher than general
Healthy group, but difference does not reach statistically significant meaning (being shown in Table 6 and Fig. 3).
5 general inferior health of table and high-risk inferior health group blood vessel elasticity index be normal and unnatural proportions
6 general inferior health of table and high-risk inferior health group blood vessel elasticity index
As seen from Figure 3, the high-risk inferior health of 3A systemic blood vessels compliance is less than general inferior health, 3B systemic vascular resistances
High-risk inferior health is higher than inferior health, and the high-risk inferior health of 3C arteria brachialis dilatancies is less than general inferior health.
(2) comparative analysis of different type inferior health group Elastic function：Blood vessel between seven hypotypes of body inferior health
The comparative analysis of elastic index, table 7 compare for contingency table, and display group difference reaches statistical significance.Further comparison among groups point
Analysis, any one of such as three indexs Indexes Abnormality is thought of as vascular function exception, then In Prehypertensive group and blood
It presses and blood glucose or the normal high level group of blood fat has the difference of statistical significance compared with raised group of no blood pressure, and other groups
Between comparing difference it is not statistically significant.Equally, there is also this phenomenons for systemic blood vessels compliance, systemic vascular resistance comparison among groups.
Arteria brachialis dilatancy is not notable in each comparison among groups difference.
Table 8 is variance analysis, equally shows that each group difference reaches statistically significant meaning.Further compare two-by-two：1. being
System vascular compliance：Simple In Prehypertensive group and blood glucose merge the normal high level group of blood fat and are less than the normal high level of simple blood fat
With the normal high level group of simple blood glucose, blood pressure merges the normal high level group of blood glucose and is less than the normal high level group of simple blood glucose, and difference reaches statistics
Learn meaning, other comparison among groups no significant differences.2. systemic vascular resistance：Simple In Prehypertensive group is higher than simple
The normal high level group of blood glucose, other comparison among groups differences do not reach statistical significance.3. arteria brachialis dilatancy：Simple blood pressure is normally high
Value and blood pressure merge blood glucose or the normal high level group of blood fat is less than the normal high level group of simple blood glucose, other comparison among groups differences are without system
Meter learns meaning (see Fig. 4).
The normal and unnatural proportions of 7 different type inferior health group Elastic function of table
The variance analysis of 8 different type inferior health group Elastic function of table
It is drawn the following conclusions by the result of study of sub-health state under above different situations：
1) only in the normal high level stage, although the vascular function of subject has received the indexs such as blood pressure, blood glucose, blood fat
It influences.Prompt：Body sub-health state will produce detrimental effect to the spring function of blood vessel.
2) blood pressure is to influence the most important factor of Elastic function, influences intensity and is higher than blood fat and blood glucose.
3) aggregation influence bigger to vascular function of a variety of cardiovascular risk factors in the normal high level stage.
4, the relationship of different physical signs and blood vessel elasticity
(1) gender, the relationship at age and blood vessel elasticity index：The difference of different sexes and age groups blood vessel elasticity index
The different statistically significant meaning of tool.Further analyze two-by-two：1. systemic blood vessels compliance：After correcting gender, each age group compares, F
It is worth=34.97, P<0.0001；Further compared two-by-two using Bonferroni methods, in 30~44 years old group and 45~54 years old group ratio
Compared with P=0.0006, for the two compared with 55~99 years old group, P values are equal<0.0001.Two gender comparisons after the correction age, P<0.0001.
2. systemic vascular resistance：After correcting gender, each age group compares, F values=17.30, P<0.0001；Using Bonferroni methods into
One step compares two-by-two, and for 30~44 years old group compared with other two groups, P values are equal<0.0001.Other two group differences do not reach statistics and anticipate
Justice, P=0.1400.Two gender comparisons after the correction age, P<0.0001.3. arteria brachialis dilatancy：After correcting gender, each age group
Compare, F values=21.36, P<0.0001；Further compared two-by-two using Bonferroni methods, 30~44 years old group with other two groups
Compare, P values are equal<0.0001.Other two group differences do not reach statistical significance, P=0.1459.Two gender comparisons after the correction age
Difference does not reach statistical significance, P=0.1943.(being shown in Table 9)
9 gender of table, the relationship at age and blood vessel elasticity index
(2) relationship of blood pressure level and blood vessel elasticity index：After correcting age-sex, different level of blood pressure subgroup blood vessel bullet
There is significant difference in property index.Further compare two-by-two, for systemic blood vessels compliance, In Prehypertensive and hypertension group
Compared with blood pressure is normally organized, P values are equal<0.0001, In Prehypertensive is compared with two groups of hypertension, P=0.0109.For system
Vascular resistence, normally group is compared with normal high level group for blood pressure, and P=0.0123, other compare two-by-two, P<0.0001.It is dynamic for the upper arm
Arteries and veins dilatancy, two groups of comparing differences of hypertension and In Prehypertensive are not statistically significant, and P=0.7109, other compare two-by-two,
P<0.0001.(being shown in Table 10)
The relationship of table 10 blood pressure level and blood vessel elasticity index
(3) relationship of obese degree and blood vessel elasticity index：Study population is being divided into body mass index just according to body mass index
Often (body mass index<24kg/m2), overweight (body mass index 24-30kg/m2) and fat (body mass index>30kg/m2) three groups, correction
After age-sex, between three groups there is significant difference in blood vessel elasticity index.Further compare two-by-two, systemic blood vessels are complied with
Property, normally group is compared with overweight group by BMI, P<0.0001, other comparison among groups differences do not reach statistical significance.For systemic blood vessels
Resistance, normally group is compared with overweight group by BMI, P<0.0001, BMI normal group is with fat group compared with, P=0.0080, overweight group and
Fat group comparing difference does not reach statistical significance.Compare two-by-two between three groups of arteria brachialis dilatancy and does not reach statistical significance.It (is shown in Table
11)
The relationship of table 11 body mass index and blood vessel elasticity index
(4) relationship of blood glucose level and blood vessel elasticity index：Either fasting blood-glucose or postprandial 2 hours blood glucose, water
The flat difference between blood vessel elasticity index does not reach statistically significant meaning.(being shown in Table 12 and table 13)
The relationship of table 12 fasting blood glucose level and blood vessel elasticity index
The relationship of table 13 postprandial 2 hours (OGTT) blood glucose levels and blood vessel elasticity index
(5) relationship of blood lipid level and blood vessel elasticity index：This research respectively consolidates low density lipoprotein cholesterol, total courage
Alcohol, total triglycerides and High-density Lipoprotein-cholesterol and blood vessel elasticity index carry out correlation analysis, and difference does not reach
Statistically significant meaning.(being shown in Table 14, table 15, table 16 and table 17)
14 low density lipoprotein cholesterol of table (LDL-C) and vascular function
15 total cholesterol of table (TC) and vascular function
16 high-density lipoprotein cholesterol of table (HDL-C) and vascular function
17 triglycerides of table (TG) and vascular function
It can be derived that by the studies above to draw a conclusion：
1) no matter masculinity femininity, with advancing age, vascular compliance decline, resistance increase；
2) same year age group, women vascular compliance are less than male, and vascular resistence is higher than male；
3) as the raising of blood pressure, vascular compliance decline, vascular resistence increases；
4) overweight and overweight people's systemic blood vessels compliance is higher than Normal-weight person, and systemic vascular resistance reduces, and reason has
It waits for further studying.
5, the relationship of inflammation index (hsCRP) and blood vessel elasticity
In recent years research finds that inflammatory reaction takes part in the development of artery sclerosis, and may partly be opened under sub-health state
Dynamic inflammatory factor, which kind of sub-health state are easy to start inflammatory factorWhat influence to vascular function isThe present invention inquires into
The above content.Using international conventional use of high-sensitive C-reactive protein (hsCRP) as the inflammation under analysis body sub-health state
Index.According to the scheme of multicenter, international large size clinical research JUPITER researchs, according to hsCRP levels<2mg/L and >=2mg/L
It is divided into two groups, it is seen that three kinds of vascular function indexs are not statistically significant in two group differences.(being shown in Table 18)
The 18 horizontal subjects of difference hsCRP of table and blood vessel elasticity Indexes Comparison
It can be derived that by the studies above to draw a conclusion：
Inflammation index is with vascular function index without significant correlation.
Two, full crowd's vascular function body overall evaluation system
The logistic regression models of whole crowds：Dependent variable is that (value range is 0~1 to vascular function situation, when being 0
Indicate normal, indicate that the risk of vascular function exception is bigger from 0 to 1), independent variable is age, gender, blood pressure, blood glucose, blood fat water
Flat, hsCRP levels, Psychological assessment and Syndrome Types of TCM etc..The parameter that model is estimated with maximum likelihood estimate, finally enters equation
Variable it is as shown in Table 19.
As can be seen from Table 19, the age 45 years old or more, body mass index is high, waistline body mass index than it is big, shrink force down and
It is the independent hazard factor of Elastic function that pulse pressure is small, and the age is wherein most important risk factor.
19 full crowd Logistic regression models of table
*：Waistline body mass index ratio=waistline (cm)/body mass index (kg/m2)
*:Pulse pressure difference=systolic pressure (mmHg)-diastolic pressure (mmHg).
The logistic regression models of whole crowds are as follows：
In formula I, when tester is male, the value of f (gender) is 0, when tester is women, f (gender)
Value be 1；
When the age of tester is 45~54 years old, the value of f (age1) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age1) is 0；
When the age of tester is 55~69 years old, the value of f (age2) is 1, is 30~54 years old when the age of tester
When, the value of f (age2) is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates waistline body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg；
In formula II, p indicates that the risk of vascular function exception occurs in tester.
Therefore using record above-mentioned model kit can the full crowd of auxiliary judgment there is the wind of vascular function exception
Danger indicates that vascular function is normal when it is 0 that p value, which is calculated, and when p value is calculated by 0 to 1, the bigger expression of p value occurs
The risk of vascular function exception is bigger.
Claims (7)
1. a kind of kit of the full crowd's vascular function of auxiliary judgment comprising parameter acquisition equipment and readable carrier；
The parameter acquisition equipment includes the equipment of the parameters involved in the acquisition readable carrier；
The content such as following formula I and formula II is described on the readability carrier,
LogitP=-0.4846-0.1188 × f (gender)+0.0807 × f (age1)
+0.2434×f(age2)+0.1602×f(bmi)-0.0433×f(waist2bmi)
- 0.0433 × f (sbp) -0.0246 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 0, and when tester is women, f (gender's) takes
Value is 1；
When the age of tester is 45~54 years old, the value of f (age1) is 1, is 30~44 years old or 55 when the age of tester
At~69 years old, the value of f (age1) is 0；
When the age of tester is 55~69 years old, the value of f (age2) is 1, when the age of tester is 30~54 years old, f
(age2) value is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates waistline body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg；
In formula II, p indicates that the risk of vascular function exception occurs in tester；
The parameter acquisition equipment includes batheroom scale, gage and sphygmomanometer.
2. kit according to claim 1, it is characterised in that：The readability carrier is kit specification；It is described
The print matter of formula I and formula II is on card.
3. kit according to claim 1, it is characterised in that：The readability carrier is computer readable carrier.
4. a kind of suit of the full crowd's vascular function of auxiliary judgment comprising measured body weight equipment, waistline measuring apparatus, blood pressure are surveyed
Amount equipment and the computing device for being provided with parameter computing module；The parameter computing module can be carried out such as following formula I and formula II
Operation：
LogitP=-0.4846-0.1188 × f (gender)+0.0807 × f (age1)
+0.2434×f(age2)+0.1602×f(bmi)-0.0433×f(waist2bmi)
- 0.0433 × f (sbp) -0.0246 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 0, and when tester is women, f (gender's) takes
Value is 1；
When the age of tester is 55~69 years old, the value of f (age2) is 1, when the age of tester is 30~54 years old, f
(age2) value is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates waistline body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg；
In formula II, p indicates that the risk of vascular function exception occurs in tester.
5. the application of parameter acquisition equipment and readable carrier in the kit for preparing the full crowd's vascular function of auxiliary judgment,
In, the parameter acquisition equipment includes the equipment of the parameters involved in the acquisition readable carrier；
The content such as following formula I and formula II is described on the readability carrier,
LogitP=-0.4846-0.1188 × f (gender)+0.0807 × f (age1)
+0.2434×f(age2)+0.1602×f(bmi)-0.0433×f(waist2bmi)
- 0.0433 × f (sbp) -0.0246 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 0, and when tester is women, f (gender's) takes
Value is 1；
When the age of tester is 45~54 years old, the value of f (age1) is 1, is 30~44 years old or 55 when the age of tester
At~69 years old, the value of f (age1) is 0；
When the age of tester is 55~69 years old, the value of f (age2) is 1, when the age of tester is 30~54 years old, f
(age2) value is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates waistline body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg；
In formula II, p indicates that the risk of vascular function exception occurs in tester；
The parameter acquisition equipment includes batheroom scale, gage and sphygmomanometer.
6. application according to claim 5, it is characterised in that：The readability carrier is kit specification；The formula I
Print matter with formula II is on card.
7. measured body weight equipment, waistline measuring apparatus, blood pressure measurement device and being provided with the computing device of parameter computing module and existing
Prepare the application in the suit of the full crowd's vascular function of auxiliary judgment, wherein the calculating for being provided with parameter computing module is set
It is standby to carry out the operation such as following formula I and formula II：
LogitP=-0.4846-0.1188 × f (gender)+0.0807 × f (age1)
+0.2434×f(age2)+0.1602×f(bmi)-0.0433×f(waist2bmi)
- 0.0433 × f (sbp) -0.0246 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 0, and when tester is women, f (gender's) takes
Value is 1；
When the age of tester is 55~69 years old, the value of f (age2) is 1, when the age of tester is 30~54 years old, f
(age2) value is 0；
F (bmi) indicates body mass index, unit kg/m2；
F (waist2bmi) indicates waistline body mass index ratio, is waistline/body mass index, unit cm/kg/m2；
F (sbp) indicates systolic pressure, unit mmHg；
F (sbp-dpb) indicates pulse pressure difference, is systolic pressure-diastolic pressure, unit mmHg；
In formula II, p indicates that the risk of vascular function exception occurs in tester.
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| CN201492415U (en) * | 2009-09-04 | 2010-06-02 | 北京麦邦光电仪器有限公司 | Blood vessel health degree detection device |
| CN104027097A (en) * | 2014-06-06 | 2014-09-10 | 首都医科大学 | Vascular function noninvasive detecting method and device |
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| CN201492415U (en) * | 2009-09-04 | 2010-06-02 | 北京麦邦光电仪器有限公司 | Blood vessel health degree detection device |
| CN104027097A (en) * | 2014-06-06 | 2014-09-10 | 首都医科大学 | Vascular function noninvasive detecting method and device |
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| 2型糖尿病主动脉顺应性及肱动脉内皮功能的3.0T高分辨磁共振研究;单艳;《中国博士学位论文全文数据库 医药卫生科技辑》;20150216;第5页、第28-29页 * |
| 基于健康体检数据库的城镇职工个体与群体健康状况综合评价系统;宋心红;《中国优秀硕士学位论文全文数据库 医药卫生科技辑》;20120515;第7-9、15-19、32-40页 * |
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