CN105361886B - A kind of kit of auxiliary judgment sub-health population systemic blood vessels compliance - Google Patents
A kind of kit of auxiliary judgment sub-health population systemic blood vessels compliance Download PDFInfo
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Abstract
The invention discloses a kind of kits of auxiliary judgment sub-health population systemic blood vessels compliance.It includes parameter acquisition equipment and readable carrier；The parameter acquisition equipment includes the equipment for acquiring parameters in the readable carrier；It is described on the readability carrier such as the content of following formula I, systemic blood vessels compliance=0.7033+0.0482 × f (gender)+0.1029 × f (age1)+0.0519 × f (age2)+0.0370 × f (bmi)+0.0752f × (waist2bmi) 0.0035 × f (sbp) 0.0052 × f (sbp dpb) formula I.Using the kit of the present invention, there is the risk of dysfunction in the systemic blood vessels compliance for being capable of auxiliary judgment sub-health population (30~69 years old).
Description
Technical field
The present invention relates to a kind of kits of auxiliary judgment sub-health population systemic blood vessels compliance, belong to biologic medical neck
Domain.
Background technology
Early in the 1980s, the World Health Organization (WHO) proposed in its work report one it is more novel
Health definition：Health refers not only to the intact shape in no disease or not weak or a kind of body, spirit and social adaptation
State.Although the definition of inferior health more unauthoritative at present, a kind of common-sense viewpoint that people generally accept at present is just
It is the new concept of health based on above-mentioned WHO, that is, thinks that so-called inferior health refers to a kind of boundary between complete health and disease
Intermediate state.The it is proposed of inferior health idea has highly important medical value and clinical meaning, because it can promote disease
" critical point " Forward of the prevention and treatment of disease.It should be pointed out that theory of medicine of this new inferior health idea early in Ancient Times in China
In just have specific discussion, wherein a kind of viewpoint generally accepted is " above curing the disease preventiveed treatment of disease ".
With advancing age, the function and structure of human vas all can gradually change.In terms of vascular function
Variation is mainly reflected in vascular stiffness increase, elasticity reduces, arterial pulse wave conduction of velocity is speeded, vascular compliance reduces,
Distensibility of blood vessel reduces or vascular resistence is increased.The change of these vascular functions is occurred often in before blood vessel structure change, but
Be this change it is usually reversible again, can be improved to a certain extent by the mode of making the life better or control underlying diseases etc.
Vascular function.Therefore, vascular function can be as a Testing index of sub-health population, to find the change of vascular function as early as possible
Change, convenient for providing medicine suggestion to sub-health population.
At present clinically there are many method of detection vascular function, but it is required for through certain specific instrument to observation pair
As being detected, and usually these instruments are all more heavy or progress network analysis is needed to obtain data, such as pulse transit
The detection of speed needs to be detected specific arteriopalmus point, and certain technology is needed to require；And the detection of ankle brachial index
Need special instrument；Systemic blood vessels compliance, systemic vascular resistance, blood vessel dilatation degree then need to arterial pulse wave waveform into
The complicated specialty analysis calculating of row can draw a conclusion.The above is all not suitable for using it for larger range of primary care
Practice.It is badly in need of a kind of method for calculating vascular function using the existing information fast of object is observed at present.
Invention content
The object of the present invention is to provide a kind of kits of auxiliary judgment sub-health population systemic blood vessels compliance, utilize this
There is the wind of dysfunction in the kit of invention, the systemic blood vessels compliance for being capable of auxiliary judgment sub-health population (30~69 years old)
Danger.
The kit of auxiliary judgment sub-health population systemic blood vessels compliance provided by the present invention, including parameter acquisition
Equipment and readable carrier；
The parameter acquisition equipment includes the equipment for acquiring parameters in the readable carrier；
It is described on the readability carrier such as the content of following formula I,
Systemic blood vessels compliance=0.7033+0.0482 × f (gender)+0.1029 × f (age1)+0.0519 × f
(age2)+0.0370×f(bmi)+0.0752f×(waist2bmi)-0.0035×f(sbp)-0.0052×f(sbp-dpb)
Formula I；
In formula I, when tester is male, the value of f (gender) is 1, when tester is women, f (gender)
Value be 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, is 45~69 years old when the age of tester
When, the value of f (age1) is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age2) is 0；
F (bmi) represents body mass index, unit kg/m2；
F (waist2bmi) represents waistline body mass index ratio, for waistline/body mass index, unit cm/kg/m2；
F (sbp) represents systolic pressure, unit mmHg；
F (sbp-dpb) represents pulse pressure difference, for systolic pressure-diastolic pressure, unit mmHg.
Above-mentioned kit, the parameter acquisition equipment includes batheroom scale, gage and sphygmomanometer, for collecting test person's
Weight, waistline, systolic pressure and diastolic pressure.
Above-mentioned kit, the readability carrier is kit specification；The print matter of the formula I on card,
Using more convenient.
Above-mentioned kit, the readability carrier is computer readable carrier.
The present invention also provides the suits of auxiliary judgment sub-health population systemic blood vessels compliance, are set including measured body weight
Standby, waistline measuring apparatus, blood pressure measurement device and the computing device for being provided with parameter computing module；The parameter computing module energy
Enough operations carried out such as following formula I：
Systemic blood vessels compliance=0.7033+0.0482 × f (gender)+0.1029 × f (age1)+0.0519 × f
(age2)+0.0370×f(bmi)+0.0752f×(waist2bmi)-0.0035×f(sbp)-0.0052×f(sbp-dpb)
Formula I；
In formula I, when tester is male, the value of f (gender) is 1, when tester is women, f (gender)
Value be 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, is 45~69 years old when the age of tester
When, the value of f (age1) is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age2) is 0；
F (bmi) represents body mass index, unit kg/m2；
F (waist2bmi) represents waistline body mass index ratio, for waistline/body mass index, unit cm/kg/m2；
F (sbp) represents systolic pressure, unit mmHg；
F (sbp-dpb) represents pulse pressure difference, for systolic pressure-diastolic pressure, unit mmHg.
The present invention also provides the users of the kit of above-mentioned auxiliary judgment sub-health population systemic blood vessels compliance
Method includes the following steps：
1) weight, waistline and the blood pressure of person to be checked are measured, and is recorded；
2) operation is carried out according to such as following formula I：
Systemic blood vessels compliance=0.7033+0.0482 × f (gender)+0.1029 × f (age1)+0.0519 × f
(age2)+0.0370×f(bmi)+0.0752f×(waist2bmi)-0.0035×f(sbp)-0.0052×f(sbp-dpb)
Formula I；
In formula I, when tester is male, the value of f (gender) is 1, when tester is women, f (gender)
Value be 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, is 45~69 years old when the age of tester
When, the value of f (age1) is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age2) is 0；
F (bmi) represents body mass index, unit kg/m2；
F (waist2bmi) represents waistline body mass index ratio, for waistline/body mass index, unit cm/kg/m2；
F (sbp) represents systolic pressure, unit mmHg；
F (sbp-dpb) represents pulse pressure difference, for systolic pressure-diastolic pressure, unit mmHg.
The present invention also provides parameter acquisition equipment and readable carrier to prepare auxiliary judgment sub-health population system blood
Application in the kit of pipe compliance, wherein, the parameter acquisition equipment includes acquiring involved in the readable carrier
The equipment of parameters；
It is described on the readability carrier such as the content of following formula I,
Systemic blood vessels compliance=0.7033+0.0482 × f (gender)+0.1029 × f (age1)+0.0519 × f
(age2)+0.0370×f(bmi)+0.0752f×(waist2bmi)-0.0035×f(sbp)-0.0052×f(sbp-dpb)
Formula I；
In formula I, when tester is male, the value of f (gender) is 1, when tester is women, f (gender)
Value be 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, is 45~69 years old when the age of tester
When, the value of f (age1) is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age2) is 0；
F (bmi) represents body mass index, unit kg/m2；
F (waist2bmi) represents waistline body mass index ratio, for waistline/body mass index, unit cm/kg/m2；
F (sbp) represents systolic pressure, unit mmHg；
F (sbp-dpb) represents pulse pressure difference, for systolic pressure-diastolic pressure, unit mmHg.
Above-mentioned application, the parameter acquisition equipment include batheroom scale, gage and sphygmomanometer.
Above-mentioned application, the readability carrier is kit specification；The print matter of the formula I is on card.
The present invention also provides measured body weight equipment, waistline measuring apparatus, blood pressure measurement device and it is provided with parameter operation
Application of the computing device of module in the suit for preparing auxiliary judgment sub-health population systemic blood vessels compliance, wherein, it is described
Being provided with the computing device of parameter computing module can carry out such as the operation of following formula I：
Systemic blood vessels compliance=0.7033+0.0482 × f (gender)+0.1029 × f (age1)+0.0519 × f
(age2)+0.0370×f(bmi)+0.0752f×(waist2bmi)-0.0035×f(sbp)-0.0052×f(sbp-dpb)
Formula I；
In formula I, when tester is male, the value of f (gender) is 1, when tester is women, f (gender)
Value be 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, is 45~69 years old when the age of tester
When, the value of f (age1) is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age2) is 0；
F (bmi) represents body mass index, unit kg/m2；
F (waist2bmi) represents waistline body mass index ratio, for waistline/body mass index, unit cm/kg/m2；
F (sbp) represents systolic pressure, unit mmHg；
F (sbp-dpb) represents pulse pressure difference, for systolic pressure-diastolic pressure, unit mmHg.
Kit of the present invention is suitable for the judgement of the vascular function of the sub-health population of 30~69 years old.
Sub-health population refers in the present invention：Blood pressure, blood fat, blood glucose, body mass index (body mass index, BMI)
Or a certain index of waistline is in the normal high level stage.
When carrying out the judgement of vascular function exception using kit of the present invention, pass through the parameter acquisition equipment collecting test
Weight, waistline, systolic pressure and the diastolic pressure of person, the gender of binding test person and age, utilize the formula described in readable carrier
I, the systemic blood vessels compliance (ml/mmHg) of subject can be obtained, by itself and critical value when age groups, different sexes
It is compared, abnormal situation occurs in the systemic blood vessels compliance that can obtain subject：As the male for 30~44 years old group
Or during women, when the systemic blood vessels compliance of subject is more than 1.2ml/mmHg, illustrating subject, there are systemic blood vessels compliances
Abnormal risk；As the male for 45~54 years old group, when the systemic blood vessels compliance of subject is more than 1.2ml/mmHg, say
Bright subject is there are the risk that systemic blood vessels comply with sexual abnormality, as the women for 45~54 years old group, the system blood of subject
When pipe compliance is more than 1.1ml/mmHg, illustrating subject, there are the risks that systemic blood vessels comply with sexual abnormality；When being 55~69 years old
During the male of group, when the systemic blood vessels compliance of subject is more than 1.1ml/mmHg, illustrate that subject is suitable there are systemic blood vessels
The risk of sexual abnormality is answered, as the women for 55~69 years old group, when the systemic blood vessels compliance of subject is more than 1ml/mmHg,
Illustrating subject, there are the risks that systemic blood vessels comply with sexual abnormality.
The kit of auxiliary judgment sub-health population systemic blood vessels compliance of the present invention, has the following advantages that：
1st, by data such as weight, waistline and the blood pressures easily obtained in clinic, direct Estimation System vascular compliance is
It is no to there is exception, be conducive to basic health mechanism medical worker and the preliminary of systemic blood vessels compliance is carried out to sub-health population of going to a doctor
Judge.
2nd, the formula I in the present invention can utilize the form of readable carrier (software), final to realize the basic ginseng of user's input
Number (gender, age, weight, waistline and blood pressure) can obtain systemic blood vessels compliance, and according to the comparison with critical value, thus
Judge that systemic blood vessels comply with the risk of sexual abnormality, be conducive to promote this method in sub-healty adults, so as to which the crowd of improving is to itself
The understanding of vascular function and attention.
Description of the drawings
Fig. 1 is healthy group, inferior health group and the comparable situation of disease group Elastic function, and in Fig. 1, systemic blood vessels are complied with
Property unit be ml/mmHg, systemic vascular resistance unit be 103·dynes/sec/cm5, arteria brachialis dilatancy unit for %/
mmHg。
Fig. 2 is the comparable situation of general inferior health and high-risk inferior health Elastic function unnatural proportions.
Fig. 3 is the comparable situation of high-risk inferior health and general inferior health person's Elastic function, and in Fig. 3, systemic blood vessels are suitable
Answering property unit is ml/mmHg, and systemic vascular resistance unit is 103·dynes/sec/cm5, arteria brachialis dilatancy unit for %/
mmHg。
Fig. 4 is the comparable situation of different type body inferior health group blood vessel elasticity index, in Fig. 4, systemic blood vessels compliance
Unit is ml/mmHg, and systemic vascular resistance unit is 103·dynes/sec/cm5, arteria brachialis dilatancy unit is %/mmHg.
Specific embodiment
Experimental method used in following embodiments is conventional method unless otherwise specified.
The materials, reagents and the like used in the following examples is commercially available unless otherwise specified.
First, subject's vascular function correlation analysis
1st, vascular function dividing value point is determining
The purpose of the present invention is the assessment of arterial function is carried out to inferior health patient.The present invention uses the U.S.
The capital equipment that Dynapulse200A arterial elasticities sensing equipment influences arterial elasticity as evaluation inferior health, selects system
The evaluation index of vascular compliance, systemic vascular resistance and arteria brachialis dilatancy as Elastic function.Determine Healthy People
The dividing value point of arterial function exceptional value is to ensure the basis that the present invention is smoothed out.Only has American exceptional value dividing value at present
Point, as shown in table 2, to ensure the function of accurately evaluation artery, first according to 300 selected Healthy People blood vessel work(of the present invention
Energy data determine the evaluation point of contact of three vascular function indexs, and as the basis of vascular function of the present invention analysis.
Since age-sex has vascular function specific influence, research object is grouped by the present invention by Sex, Age, bullet
Property index is using 20% lower limit of normal person as boundary's point value, and Drag Indices are using 80% upper limit of normal person as boundary's point value, concrete numerical value
It is shown in Table 1.
The dividing value point of 1 three elastic indexs of age groups of the present invention of table
2 American population vascular function dividing value point of table
2nd, Body health, body inferior health and sick people's Elastic function data analysis
(1) classified data is analyzed：Blood vessel elasticity index is divided into Critical anomaly and normal two according to above-mentioned determining dividing value
Group is compared in different crowd.Using contingency table Chi-square Test, the normal and unnatural proportions of three groups of blood vessel elasticity indexs are shown in
Table 3, difference still reaches statistical significance after calibrated age-sex.Further compare two-by-two, it is healthy compared with inferior health group, SVC,
The P values of SVR and BAD are respectively 0.0452,0.6420 and 0.0005；Healthy group compared with disease group, P values are respectively<0.0001,
0.0079 and 0.0001；Inferior health P values compared with disease group are respectively 0.0072,0.0092 and 0.4389.
The different group blood vessel elasticity Indexes Abnormality situations of table 3 compare (n=1297)
(2) measurement data is analyzed：The measure mean value and standard deviation of three kinds of blood vessel elasticity indexs of each group are shown in Table 4.Using variance
The difference of blood vessel elasticity index between each group is compared in analysis, and difference still reaches statistical significance after calibrated age-sex.Further two
Two compare：Systemic blood vessels comply with sex-health compared with inferior health group, P<0.0001, health group is compared with disease group, P=
0.0046, inferior health group is compared with disease group, P=0.0020.Systemic vascular resistance inferior health, disease group are compared with healthy group, P
Value is respectively 0.0377 and 0.0442, and inferior health and disease group comparing difference are not statistically significant.
The different group blood vessel elasticity Indexes Comparisons of table 4
As seen from Figure 1, with the difference of health status：Health, inferior health, disease, systemic blood vessels compliance (SVC)
It is continuously decreasing, systemic vascular resistance (SVR) gradually increases, and arteria brachialis dilatancy (BAD) gradually declines.
3rd, different degrees of and different type body inferior health Elastic function analysis
(1) general inferior health and the comparative analysis of high-risk inferior health patient vessel spring function：Systemic blood vessels compliance is different
Often or arteria brachialis expansion sexual abnormality person is more than general inferior health group, two groups of systemic vascular resistance abnormal rate in high-risk inferior health group
Without significant difference.Contingency table is relatively shown in Table 5 and Fig. 2, and variance analysis is shown in Table 6.
Variance analysis shows that high-risk inferior health system system vascular compliance and arteria brachialis dilatancy are less than general inferior health
Group, difference is still up to statistically significant meaning after correcting age-sex, and the high-risk inferior health group of systemic vascular resistance is higher than general Asia
Healthy group, but difference does not reach statistically significant meaning (being shown in Table 6 and Fig. 3).
5 general inferior health of table and high-risk inferior health group blood vessel elasticity index be normal and unnatural proportions
6 general inferior health of table and high-risk inferior health group blood vessel elasticity index
As seen from Figure 3, the high-risk inferior health of 3A systemic blood vessels compliance is less than general inferior health, 3B systemic vascular resistances
High-risk inferior health is higher than inferior health, and the high-risk inferior health of 3C arteria brachialis dilatancies is less than general inferior health.
(2) comparative analysis of different type inferior health group Elastic function：
The comparative analysis of blood vessel elasticity index between seven hypotypes of body inferior health, table 7 compares for contingency table, between display group
Difference reaches statistical significance.Further comparison among groups analysis, as any one Indexes Abnormality is thought of as blood vessel in three indexs
Dysfunction, then In Prehypertensive group and blood pressure merge raised group of phase of blood glucose or the normal high level group of blood fat and no blood pressure
Than there are the difference of statistical significance, and other comparison among groups no significant differences.Equally, systemic blood vessels compliance,
There is also this phenomenons for systemic vascular resistance comparison among groups.Arteria brachialis dilatancy is not notable in each comparison among groups difference.
Table 8 is variance analysis, equally shows that each group difference reaches statistically significant meaning.Further compare two-by-two：1. it is
System vascular compliance：Simple In Prehypertensive group and blood glucose merge the normal high level group of blood fat and are less than the normal high level of simple blood fat
With the normal high level group of simple blood glucose, blood pressure merges the normal high level group of blood glucose less than the normal high level group of simple blood glucose, and difference reaches statistics
Learn meaning, other comparison among groups no significant differences.2. systemic vascular resistance：Simple In Prehypertensive group is higher than simple
The normal high level group of blood glucose, other comparison among groups differences do not reach statistical significance.3. arteria brachialis dilatancy：Simple blood pressure is normally high
Value and blood pressure merge blood glucose or the normal high level group of blood fat less than the normal high level group of simple blood glucose, other comparison among groups differences are without system
Meter learns meaning (see Fig. 4).
The normal and unnatural proportions of 7 different type inferior health group Elastic function of table
The variance analysis of 8 different type inferior health group Elastic function of table
It is drawn the following conclusions by the result of study of sub-health state under above different situations：
1) only in the normal high level stage, although the vascular function of subject has received the indexs such as blood pressure, blood glucose, blood fat
It influences.Prompting：Body sub-health state can have adverse effect on the spring function of blood vessel.
2) blood pressure is to influence the most important factor of Elastic function, influences intensity and is higher than blood fat and blood glucose.
3) a variety of cardiovascular risk factors are in the influence bigger of the aggregation to vascular function in normal high level stage.
4th, different physical signs and the relationship of blood vessel elasticity
(1) relationship of gender, age and blood vessel elasticity index：The difference of different sexes and age groups blood vessel elasticity index
The different statistically significant meaning of tool.Further analyze two-by-two：1. systemic blood vessels compliance：After correcting gender, each age group compares, F
It is worth=34.97, P<0.0001；Further compared two-by-two using Bonferroni methods, in 30~44 years old group and 45~54 years old group ratio
Compared with P=0.0006, for the two compared with 55~99 years old group, P values are equal<0.0001.Two gender comparisons after the correction age, P<0.0001.
2. systemic vascular resistance：After correcting gender, each age group compares, F values=17.30, P<0.0001；Using Bonferroni methods into
One step compares two-by-two, and for 30~44 years old group compared with other two groups, P values are equal<0.0001.Other two group differences are not anticipated up to statistics
Justice, P=0.1400.Two gender comparisons after the correction age, P<0.0001.3. arteria brachialis dilatancy：After correcting gender, each age group
Compare, F values=21.36, P<0.0001；Further compared two-by-two using Bonferroni methods, 30~44 years old group with other two groups
Compare, P values are equal<0.0001.Other two group differences are not up to statistical significance, P=0.1459.Two gender comparisons after the correction age
Difference is not up to statistical significance, P=0.1943.(being shown in Table 9)
The relationship of 9 gender of table, age and blood vessel elasticity index
(2) relationship of blood pressure level and blood vessel elasticity index：After correcting age-sex, different level of blood pressure subgroup blood vessel bullet
There are significant differences for property index.Further compare two-by-two, for systemic blood vessels compliance, In Prehypertensive and hypertension group
Compared with blood pressure is normally organized, P values are equal<0.0001, In Prehypertensive is compared with two groups of hypertension, P=0.0109.For system
Vascular resistence, normally group is compared with normal high level group for blood pressure, and P=0.0123, other compare two-by-two, P<0.0001.The upper arm is moved
Arteries and veins dilatancy, two groups of comparing differences of hypertension and In Prehypertensive are not statistically significant, and P=0.7109, other compare two-by-two,
P<0.0001.(being shown in Table 10)
The relationship of 10 blood pressure level of table and blood vessel elasticity index
(3) obese degree and the relationship of blood vessel elasticity index：Study population is being divided into just by body mass index according to body mass index
Often (body mass index<24kg/m2), overweight (body mass index 24-30kg/m2) and fat (body mass index>30kg/m2) three groups, correction
After age-sex, there are significant differences for blood vessel elasticity index between three groups.Further compare two-by-two, systemic blood vessels are complied with
Property, normally group is compared with overweight group by BMI, P<0.0001, other comparison among groups differences do not reach statistical significance.For systemic blood vessels
Resistance, normally group is compared with overweight group by BMI, P<0.0001, BMI normal group is with fat group compared with, P=0.0080, overweight group and
Fat group comparing difference does not reach statistical significance.Compare two-by-two between three groups of arteria brachialis dilatancy and do not reach statistical significance.It (is shown in Table
11)
11 body mass index of table and the relationship of blood vessel elasticity index
(4) relationship of blood glucose level and blood vessel elasticity index：Either fasting blood-glucose or postprandial 2 hours blood glucose, water
The flat difference between blood vessel elasticity index does not reach statistically significant meaning.(being shown in Table 12 and table 13)
12 fasting blood glucose level of table and the relationship of blood vessel elasticity index
The relationship of 13 postprandial 2 hours (OGTT) blood glucose levels of table and blood vessel elasticity index
(5) blood lipid level and the relationship of blood vessel elasticity index：This research respectively consolidates low density lipoprotein cholesterol, total courage
Alcohol, total triglycerides and High-density Lipoprotein-cholesterol and blood vessel elasticity index carry out correlation analysis, and difference does not reach
Statistically significant meaning.(being shown in Table 14, table 15, table 16 and table 17)
14 low density lipoprotein cholesterol of table (LDL-C) and vascular function
15 T-CHOL of table (TC) and vascular function
16 high-density lipoprotein cholesterol of table (HDL-C) and vascular function
17 triglycerides of table (TG) and vascular function
It can be derived that draw a conclusion by the studies above：
1) no matter masculinity femininity, with advancing age, vascular compliance decline, resistance increase；
2) same year age group, women vascular compliance are less than male, and vascular resistence is higher than male；
3) as the raising of blood pressure, vascular compliance decline, vascular resistence increases；
4) overweight and overweight people's systemic blood vessels compliance is reduced higher than Normal-weight person, systemic vascular resistance, and reason has
It treats further to study.
5th, the relationship of inflammation index (hsCRP) and blood vessel elasticity
In recent years research finds that inflammatory reaction takes part in the development of artery sclerosis, and may partly be opened under sub-health state
Dynamic inflammatory factor, which kind of sub-health state easily start inflammatory factorWhat influence to vascular function isThe present invention inquires into
More than content.Using international conventional use of high-sensitive C-reactive protein (hsCRP) as the inflammation under analysis body sub-health state
Index.According to the scheme that multicenter, international large size clinical research JUPITER is studied, according to hsCRP levels<2mg/L and >=2mg/L
It is divided into two groups, it is seen that three kinds of vascular function indexs are not statistically significant (being shown in Table 18) in two group differences.
The 18 horizontal subjects of difference hsCRP of table and blood vessel elasticity Indexes Comparison
It can be derived that draw a conclusion by the studies above：
Inflammation index is with vascular function index without significant correlation.
2nd, the linear regression model (LRM) for the sub-health population that systemic blood vessels compliance participates in
In sub-health population using vascular function index as dependent variable, with gender, age, blood pressure, blood glucose, blood lipid level, body
Weight index, waistline, hsCRP levels, Psychological assessment, Syndrome Types of TCM etc. carry out multiple linear regression analysis (specific number for independent variable
According to being shown in Table 19).
19 systemic blood vessels compliance linear regression model (LRM) of table
*:Waistline body mass index ratio=waistline (cm)/body mass index (kg/m2)
**:Pulse pressure difference=systolic pressure (mmHg)-diastolic pressure (mmHg)
Systemic blood vessels compliance=0.7033+0.0482 × f (gender)+0.1029 × f (age1)+0.0519 × f
(age2)+0.0370×f(bmi)+0.0752f×(waist2bmi)-0.0035×f(sbp)-0.0052×f(sbp-dpb)
Formula I；
In formula I, when tester is male, the value of f (gender) is 1, when tester is women, f (gender)
Value be 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, is 45~69 years old when the age of tester
When, the value of f (age1) is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old when the age of tester
Or at 55~69 years old, the value of f (age2) is 0；
F (bmi) represents body mass index, unit kg/m2；
F (waist2bmi) represents waistline body mass index ratio, for waistline/body mass index, unit cm/kg/m2；
F (sbp) represents systolic pressure, unit mmHg；
F (sbp-dpb) represents pulse pressure difference, for systolic pressure-diastolic pressure, unit mmHg.
The critical point of age groups systemic blood vessels compliance is as shown in table 20.
The dividing value point of 20 age groups systemic blood vessels compliance of table
Therefore using record above-mentioned model kit can auxiliary judgment sub-health population there are systemic blood vessels and comply with
The situation of sexual abnormality compares the systemic blood vessels compliance of the subject obtained according to above-mentioned model with the critical point in table 20
Compared with abnormal situation occurs in the systemic blood vessels compliance that can obtain subject：When the male or female for 30~44 years old group
When, when the systemic blood vessels compliance of subject is more than 1.2ml/mmHg, illustrate subject there are systemic blood vessels to comply with sexual abnormality
Risk；As the male for 45~54 years old group, when the systemic blood vessels compliance of subject is more than 1.2ml/mmHg, illustrate tested
Person is there are the risk that systemic blood vessels comply with sexual abnormality, and as the women for 45~54 years old group, the systemic blood vessels of subject are complied with
Property be more than 1.1ml/mmHg when, illustrating subject, there are the risks that systemic blood vessels comply with sexual abnormality；When for 55~69 years old group
During male, when the systemic blood vessels compliance of subject is more than 1.1ml/mmHg, illustrating subject, there are systemic blood vessels compliance is different
Normal risk, as the women for 55~69 years old group, when the systemic blood vessels compliance of subject is more than 1ml/mmHg, illustrate by
There are the risks that systemic blood vessels comply with sexual abnormality by examination person.
Claims (8)
1. a kind of kit of auxiliary judgment sub-health population systemic blood vessels compliance, including parameter acquisition equipment and readability
Carrier；
The parameter acquisition equipment includes the equipment for acquiring parameters in the readable carrier；
The parameter acquisition equipment includes batheroom scale, gage and sphygmomanometer；
It is described on the readability carrier such as the content of following formula I,
Systemic blood vessels compliance=0.7033+0.0482 × f (gender)+0.1029 × f (age1)+0.0519 × f (age2)+
0.0370 × f (bmi)+0.0752f × (waist2bmi) -0.0035 × f (sbp) -0.0052 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, and when tester is women, f (gender's) takes
Be worth is 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, when the age of tester is 45~69 years old, f
(age1) value is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old or 55 when the age of tester
At~69 years old, the value of f (age2) is 0；
F (bmi) represents body mass index, unit kg/m2；
F (waist2bmi) represents waistline body mass index ratio, for waistline/body mass index, unit cm/kg/m2；
F (sbp) represents systolic pressure, unit mmHg；
F (sbp-dpb) represents pulse pressure difference, for systolic pressure-diastolic pressure, unit mmHg.
2. kit according to claim 1, it is characterised in that：The readability carrier is kit specification；It is described
The print matter of formula I is on card.
3. kit according to claim 1, it is characterised in that：The readability carrier is computer readable carrier.
4. a kind of suit of auxiliary judgment sub-health population systemic blood vessels compliance is measured including measured body weight equipment, waistline
Equipment, blood pressure measurement device and the computing device for being provided with parameter computing module；The parameter computing module can carry out as follows
The operation of formula I：
Systemic blood vessels compliance=0.7033+0.0482 × f (gender)+0.1029 × f (age1)+0.0519 × f (age2)+
0.0370 × f (bmi)+0.0752f × (waist2bmi) -0.0035 × f (sbp) -0.0052 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, and when tester is women, f (gender's) takes
Be worth is 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, when the age of tester is 45~69 years old, f
(age1) value is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old or 55 when the age of tester
At~69 years old, the value of f (age2) is 0；
F (bmi) represents body mass index, unit kg/m2；
F (waist2bmi) represents waistline body mass index ratio, for waistline/body mass index, unit cm/kg/m2；
F (sbp) represents systolic pressure, unit mmHg；
F (sbp-dpb) represents pulse pressure difference, for systolic pressure-diastolic pressure, unit mmHg.
5. the application method of the kit of the auxiliary judgment sub-health population systemic blood vessels compliance described in claim 1-3, packet
Include following steps：
1) weight, waistline and the blood pressure of person to be checked are measured, and is recorded；
2) operation is carried out according to such as following formula I：
Systemic blood vessels compliance=0.7033+0.0482 × f (gender)+0.1029 × f (age1)+0.0519 × f (age2)+
0.0370 × f (bmi)+0.0752f × (waist2bmi) -0.0035 × f (sbp) -0.0052 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, and when tester is women, f (gender's) takes
Be worth is 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, when the age of tester is 45~69 years old, f
(age1) value is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old or 55 when the age of tester
At~69 years old, the value of f (age2) is 0；
F (bmi) represents body mass index, unit kg/m2；
F (waist2bmi) represents waistline body mass index ratio, for waistline/body mass index, unit cm/kg/m2；
F (sbp) represents systolic pressure, unit mmHg；
F (sbp-dpb) represents pulse pressure difference, for systolic pressure-diastolic pressure, unit mmHg.
6. parameter acquisition equipment and readable carrier are in the kit for preparing auxiliary judgment sub-health population systemic blood vessels compliance
In application, wherein, the parameter acquisition equipment includes the equipment for acquiring the parameters involved in the readable carrier；
The parameter acquisition equipment includes batheroom scale, gage and sphygmomanometer；
It is described on the readability carrier such as the content of following formula I,
Systemic blood vessels compliance=0.7033+0.0482 × f (gender)+0.1029 × f (age1)+0.0519 × f (age2)+
0.0370 × f (bmi)+0.0752f × (waist2bmi) -0.0035 × f (sbp) -0.0052 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, and when tester is women, f (gender's) takes
Be worth is 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, when the age of tester is 45~69 years old, f
(age1) value is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old or 55 when the age of tester
At~69 years old, the value of f (age2) is 0；
F (bmi) represents body mass index, unit kg/m2；
F (waist2bmi) represents waistline body mass index ratio, for waistline/body mass index, unit cm/kg/m2；
F (sbp) represents systolic pressure, unit mmHg；
F (sbp-dpb) represents pulse pressure difference, for systolic pressure-diastolic pressure, unit mmHg.
7. application according to claim 6, it is characterised in that：The readability carrier is kit specification；The formula I
Print matter on card.
8. it measured body weight equipment, waistline measuring apparatus, blood pressure measurement device and is provided with the computing device of parameter computing module and exists
The application in the suit of auxiliary judgment sub-health population systemic blood vessels compliance is prepared, wherein, it is described to be provided with parameter operation mould
The computing device of block can be carried out such as the operation of following formula I：
Systemic blood vessels compliance=0.7033+0.0482 × f (gender)+0.1029 × f (age1)+0.0519 × f (age2)+
0.0370 × f (bmi)+0.0752f × (waist2bmi) -0.0035 × f (sbp) -0.0052 × f (sbp-dpb) formula I；
In formula I, when tester is male, the value of f (gender) is 1, and when tester is women, f (gender's) takes
Be worth is 0；
When the age of tester is 30~44 years old, the value of f (age1) is 1, when the age of tester is 45~69 years old, f
(age1) value is 0；
When the age of tester is 45~54 years old, the value of f (age2) is 1, is 30~44 years old or 55 when the age of tester
At~69 years old, the value of f (age2) is 0；
F (bmi) represents body mass index, unit kg/m2；
F (waist2bmi) represents waistline body mass index ratio, for waistline/body mass index, unit cm/kg/m2；
F (sbp) represents systolic pressure, unit mmHg；
F (sbp-dpb) represents pulse pressure difference, for systolic pressure-diastolic pressure, unit mmHg.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5400793A (en) * | 1991-01-29 | 1995-03-28 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Method of determining the stroke volume and the cardiac output of the human heart |
| CN1593330A (en) * | 2004-06-17 | 2005-03-16 | 肖行贯 | Cardiovascular dynamics checking checkup method |
| CN101224106A (en) * | 2008-02-01 | 2008-07-23 | 山东大学 | Detecting method for human body artery compliance and device thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080015451A1 (en) * | 2006-07-13 | 2008-01-17 | Hatib Feras S | Method and Apparatus for Continuous Assessment of a Cardiovascular Parameter Using the Arterial Pulse Pressure Propagation Time and Waveform |
-
2015
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5400793A (en) * | 1991-01-29 | 1995-03-28 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Method of determining the stroke volume and the cardiac output of the human heart |
| CN1593330A (en) * | 2004-06-17 | 2005-03-16 | 肖行贯 | Cardiovascular dynamics checking checkup method |
| CN101224106A (en) * | 2008-02-01 | 2008-07-23 | 山东大学 | Detecting method for human body artery compliance and device thereof |
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| Title |
|---|
| 高血压病患者动脉顺应性改变及其影响因素的研究;吴格如;《中华心血管病杂志》;20040731;第32卷(第7期);592-595 * |
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