CN105267746A - Traditional Chinese medicine composition for treating gomphiasis caused by stomach latent fire - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating gomphiasis caused by stomach latent fire. The traditional Chinese medicine composition for treating gomphiasis caused by stomach latent fire comprises the following various components according to weight unit: 40-60 g of gypsum, 40-60 g of phillyrin, 40-60 g of coptidis rhizoma, 40-60 g of pinellia ternate, 20-40 g of rhizoma cimicifugae, 20-40 g of dried radix rehmanniae, 20-40 g of cortex magnoliae officinalis, 20-40 g of Angelica sinensis, 20-40 g of ginseng, 20-40 g of folium phyllostachys, 20-40 g of hawthorn, 20-40 g of medicated leaven, 10-20 g of radix angelicae dahuricae, 10-20 g of asarum, 10-20 g of radix sophorae tonkinensis, 10-20 g of pipewort, 10-20 g of rhizoma nardostachyos, 10-20 g of drynaria total flavonoids, 10-20 g of folium artemisiae argyi, 10-20 g of caulis sargentodoxae, 5-10 g of chalcanthite and 10-20 g of radix glycyrrhizae. The traditional Chinese medicine composition is simple in proportion and convenient to use, and has effects of clearing away stomach-heat and purging fire, and strengthening teeth and diminishing inflammation, and effective rate of treatment of gomphiasis is high.

Description

A kind of Chinese medicine composition being used for the treatment of odontoseisis caused by the stomach fire second of the three ten-day periods of the hot season

technical field:

The present invention relates to traditional Chinese medicine technical field of pharmaceuticals, particularly relate to a kind of Chinese medicine composition being used for the treatment of odontoseisis caused by the stomach fire second of the three ten-day periods of the hot season.

background technology:

Odontoseisis, refers to that odontoseisis degree exceedes normal physiologic range.Tooth has certain mobility in health status, mainly horizontal direction, and vertical direction is very small especially, is no more than 0.02mm, not easily discovered.When causing the mobility of tooth to be greater than this scope due to some disease factor or other factors, be just called odontoseisis.Odontoseisis can acutely cause or chronic slow progress, can be uncomfortable with dental pain, also can be without.The major effect caused people is laboratory rodent chow is feel unable or uncomfortable.Different by the degree of odontoseisis, I degree ~ III degree three calibration can be divided into clinically.I degree of odontoseisis be the dynamic degree in cheek tongue direction (inward-outward direction) within 1mm, the dynamic degree in other directions; II degree of odontoseisis has two kinds of situations, one be the dynamic degree in cheek tongue direction (inward-outward direction) between 1 ~ 2mm, two for tooth have cheek tongue direction (inward-outward direction) and near far away in the dynamic degree of direction (left and right directions) both direction; III degree of odontoseisis also has two kinds of situations, one be the dynamic degree in cheek tongue direction (inward-outward direction) more than 2mm, two for tooth there is cheek tongue direction (inward-outward direction), near far away in the dynamic degree in direction (left and right directions) and vertical direction (above-below direction) three directions.More and more heavier from the degree of I degree ~ III degree of odontoseisis, also have increasing impact to the life of patient, generally loss of tooth maybe needs the probability pulled out also larger.

The traditional Chinese medical science proves odontoseisis, sees " Standards of Diagnosis and Treatment miscellaneous diseases ", has another name called teeth and floats.Cause the reason of odontoseisis to have: 1. dental caries worm-eaten eats hollow, cause the tooth person of shaking; 2. the stomach fire second of the three ten-day periods of the hot season, fire-toxin is attacked and the tooth person of shaking; 3. because of asthenia of renal qi, can not teeth consolidating, cause gingival atrophy and tooth person of shaking etc.

In prior art, there is a lot of traditional Chinese medicine thing for odontoseisis.Control tooth as Chinese patent application 201010585693.7 1 kinds and shake pain, teeth consolidating hair color toothpaste, comprises the raw material of following weight portion: select Fructus Gleditsia 10 parts, Sal 4 parts, Rhizoma Cyperi 4 parts, Halitum 4 parts, Fructus Arctii 4 parts, Stamen Nelumbinis 1 part, Herba Pogostemonis 1 part, Herba Ecliptae 1 part, Semen Sesami Nigrum 1 part, 1 part, dry Rhizoma Zingiberis Recens, Radix Rehmanniae 1 part, Herba Asari 1 part.

Chinese patent application 201210276722.0 for the oral liquid of odontoseisis, be with the medicine of following portions by weight for crude drug prepares: Radix Angelicae Dahuricae 15-40, Radix Achyranthis Bidentatae 15-40, Rhizoma Drynariae 15-40, Flos Lonicerae 15-40, Flos Magnoliae 5-10, Bulbus Fritillariae Cirrhosae 1-3, Radix Notoginseng 1-3, Radix Glehniae 5-7, Semen Armeniacae Amarum 4-10, Radix Scrophulariae 3-9, Radix Ophiopogonis 2-5, Rhizoma Polygonati Odorati 2-6, Radix Bupleuri 2-7, Semen Sterculiae Lychnophorae 2-7, Radix Scutellariae 1-3, Radix Gentianae 1-3, Indigo Naturalis 1-3, Radix Glycyrrhizae 1-3, Rhizoma Belamcandae 2-4, Radix Platycodonis 2-4, Herba Menthae 2-4, Radix Sophorae Flavescentis 2-4, propolis 2-4, potassium sorbate 0.2-0.4.Chinese patent application 201410430289.0 1 kinds can control the Chinese medicine formula of odontoseisis pain, making this formula active ingredient raw materials is Radix Rehmanniae and Radix Angelicae Pubescentis, its raw material counterweight and using method thereof: Radix Rehmanniae 90 grams, Radix Angelicae Pubescentis 90 grams, medicine is chopped up, put into 500 ml waters and soak a night, each containing this water 3-5 minute.

But traditional Chinese medicine thing of the prior art does not accomplish classification therapy, therefore therapeutic effect is bad.In view of this technical problem, it is simple, easy to use that the present invention is intended to inquire into a kind of proportioning, eliminating stomach-fire, a kind of Chinese medicine composition being used for the treatment of odontoseisis caused by the stomach fire second of the three ten-day periods of the hot season of teeth consolidating antiinflammatory.

summary of the invention:

The object of the invention is to based on prior art, provide a kind of proportioning simple, easy to use, eliminating stomach-fire, a kind of Chinese medicine composition being used for the treatment of odontoseisis caused by the stomach fire second of the three ten-day periods of the hot season of teeth consolidating antiinflammatory.

To achieve these goals, the invention provides a kind of Chinese medicine composition being used for the treatment of odontoseisis caused by the stomach fire second of the three ten-day periods of the hot season, wherein, according to the following each component of unit of weight configuration:

Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 40-60g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 20-40g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 10-20g of Caulis Sargentodoxae, Chalcanthitum 5-10g, Radix Glycyrrhizae 10-20g.

Or, according to the following each component of unit of weight configuration:

Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 40-50g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 20-30g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 10-15g of Caulis Sargentodoxae, Chalcanthitum 5-8g, Radix Glycyrrhizae 10-15g.

Or, according to the following each component of unit of weight configuration:

Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 50-60g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 30-40g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 15-20g of Caulis Sargentodoxae, Chalcanthitum 8-10g, Radix Glycyrrhizae 15-20g.

During preparation: by each crude drug component mixing in above-mentioned Chinese medicine composition, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the present invention.

Using method, mixing in water for oral taking, medicated powder warm water is taken after mixing it with water, every day three times, within three days, is a course for the treatment of.

The present invention with eliminating stomach-fire to Gypsum Fibrosum, Fructus Forsythiae, clearing stomach the turbid descending be monarch drug to medicine Rhizoma Coptidis, the Rhizoma Pinelliae.With clearing stomach promote the production of body fluid to medicine Rhizoma Cimicifugae, the Radix Rehmanniae, stomach warming and blood to web Piao, Radix Angelicae Sinensis, QI invigorating nourishing the stomach to medicine Radix Ginseng, Folium Bambusae, dyspepsia and intestinal stasis relieving to Fructus Crataegi, Massa Medicata Fermentata ministerial drug.With the Radix Angelicae Dahuricae of reducing swelling and alleviating pain, the Herba Asari of dispelling wind and relieving pain, heat-clearing and toxic substances removing removes the Radix Sophorae Tonkinensis of gingival swelling and pain, dispelling wind and heat pathogens removes the Flos Eriocauli of having a toothache, the Radix Et Rhizoma Nardostachyos of promoting the circulation of QI to relieve pain, continuous muscle of invigorating blood circulation, the Rhizoma Drynariae of Psoralen bone strengthening, warming the meridian for stopping bleeding, the Folium Artemisiae Argyi of dispersing cold for relieving pain, heat-clearing and toxic substances removing, the Caulis Sargentodoxae of promoting blood circulation and stopping pain, removing toxic substances goes the Chalcanthitum (Chalcanthitum is poisonous, and consumption is little) of having a toothache to be adjuvant drug, with Radix Glycyrrhizae for making medicine.Proportioning of the present invention is simple, easy to use, eliminating stomach-fire, teeth consolidating antiinflammatory, evident in efficacy to odontoseisis caused by the stomach fire second of the three ten-day periods of the hot season.

detailed description of the invention:

Be used for the treatment of the Chinese medicine composition of odontoseisis caused by the stomach fire second of the three ten-day periods of the hot season, wherein, according to the following each component of unit of weight configuration:

Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 40-60g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 20-40g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 10-20g of Caulis Sargentodoxae, Chalcanthitum 5-10g, Radix Glycyrrhizae 10-20g.

Or, according to the following each component of unit of weight configuration:

Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 40-50g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 20-30g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 10-15g of Caulis Sargentodoxae, Chalcanthitum 5-8g, Radix Glycyrrhizae 10-15g.

Or, according to the following each component of unit of weight configuration:

Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 50-60g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 30-40g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 15-20g of Caulis Sargentodoxae, Chalcanthitum 8-10g, Radix Glycyrrhizae 15-20g.

During preparation: by each crude drug component mixing in above-mentioned Chinese medicine composition, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the present invention.

Using method, mixing in water for oral taking, medicated powder warm water is taken after mixing it with water, every day three times, within three days, is a course for the treatment of.

Comparative test:

The traditional Chinese medical science stomach second of the three ten-day periods of the hot season fire refer to intimately flourishing, stop up stagnant in the syndrome caused by stomach, card is shown in the scorching hot or causalgia of gastral cavilty, the diseases such as thirst and liking cold drink, gingival swelling and pain, odontoseisis, constipation yellowish urine.

Modeling:

Setting laboratory temperature is 18-27 degree Celsius, and humidity is 45-75%, quiet environment (lower than 50 decibels), modeling group rat 40, and with ginger ale decoct to rat oral gavage, dosage is 5ml/kg, and administration time is 2 weeks; Blank group rat 20, to equivalent distilled water.

The deliberated index of stomach-fire card animal model:

Primary symptom, thirst and liking drink, daily drink amount increases by more than 10%; Red tongue; There is I degree or II degree of odontoseisis phenomenon in swelling and aching of gum and tooth.

Secondary disease, appetite increases by more than 10%; Feces amount reduces more than 10%, has dry and hard appearance; The minimizing more than 10% of urine amount, urine comparatively modeling is front yellow, with more for referencial use than chromatic graph.

Histological examination: gastric mucosa diffusivity is congested, the secretion of mucomembranous surface myxocyte reduces, and chief cell reduces.

Modeling group 40 only with 20 comparisons of blank group, after 2 weeks, at least contain primary symptom and time disease of These parameters, the model of odontoseisis caused by the stomach fire second of the three ten-day periods of the hot season becomes.

The rat of 40 modeling groups is divided into 4 groups, often organizes 10.

First group of feeding the present invention (prescription: Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 60g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 40g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 20g of Caulis Sargentodoxae, Chalcanthitum 10g, Radix Glycyrrhizae 20g.During preparation: by each crude drug component mixing in above-mentioned Chinese medicine composition, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the present invention).Each feeding 3g mixing in water for oral taking, three times on the one.

Second group uses each feeding 5g of background technology 201010585693.7 teeth consolidating hair color toothpaste.

3rd group uses background technology 201210276722.0 for the oral liquid of odontoseisis, each 5ml.

The 4th group of herb liquid using background technology 201410430289.0 to control odontoseisis pain, each 5ml.

After 8 days, therapeutic effect contrast is as following table

Object lesson 1

Hu, usually to light a fire addicted to pungent, rich, the heat-transformation of food, intimately flourishing, stop up that stagnant gastral cavilty is scorching hot in stomach, thirst and liking cold drink, gingival swelling and pain, odontoseisis, constipation yellowish urine, odontoseisis II degree.Use the present invention: Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 60g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 40g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 20g of Caulis Sargentodoxae, Chalcanthitum 10g, Radix Glycyrrhizae 20g.During preparation: by each crude drug component mixing in above-mentioned Chinese medicine composition, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the present invention.Using method, mixing in water for oral taking, 15g medicated powder warm water is taken after mixing it with water, every day three times, within three days, is a course for the treatment of.After 2 courses for the treatment of, recovery from illness.

Object lesson 2

Week certain, feelings will is unsuccessful, stagnated QI transforming into fire, intimately flourishing, stop up that stagnant gastral cavilty is scorching hot in stomach, thirst and liking cold drink, gingival swelling and pain, odontoseisis, constipation yellowish urine, odontoseisis II degree.Use the present invention: Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 50g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 30g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 15g of Caulis Sargentodoxae, Chalcanthitum 8g, Radix Glycyrrhizae 15g.During preparation: by each crude drug component mixing in above-mentioned Chinese medicine composition, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the present invention.Using method, mixing in water for oral taking, 12g medicated powder warm water is taken after mixing it with water, every day three times, within three days, is a course for the treatment of.After 2 courses for the treatment of, recovery from illness.

Object lesson 3

Liu, lights a fire addicted to pungent, rich, the heat-transformation of food usually, intimately flourishing, stop up that stagnant gastral cavilty is scorching hot in stomach, thirst and liking cold drink, gingival swelling and pain, odontoseisis, constipation yellowish urine, odontoseisis I degree.Use the present invention: Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 55g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 35g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 18g of Caulis Sargentodoxae, Chalcanthitum 5g, Radix Glycyrrhizae 18g.During preparation: by each crude drug component mixing in above-mentioned Chinese medicine composition, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the present invention.Using method, mixing in water for oral taking, 10g medicated powder warm water is taken after mixing it with water, every day three times, within three days, is a course for the treatment of.After 3 courses for the treatment of, recovery from illness.

Acute toxicity test:

Application NIH mice 120, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity testing.Mice is divided into three groups at random, (concentration is 6.28g crude drug/ml to the Chinese medicine composition of i.e. matched group, administration object lesson 1 of the present invention, maximum concentration) administration group 1 and administration object lesson 2 of the present invention (concentration is 6.28g crude drug/ml, maximum concentration) the administration group 2 of Chinese medicine composition, fasting 12 hours before experiment.Chinese medicinal powder prepared by object lesson 1 of the present invention and object lesson 2 is dissolved in water mouse stomach by administration group 1 and administration group 2 respectively, gavage volume is 5ml/kg (namely unit dosage form is 31.4g crude drug/kg), matched group gives normal saline, administration in 1 day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, ingest, drink water, body weight increases all normal.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.

Therapeutic effect compares:

In 4 hospitals, screening 160 II degree stomach-fires cause odontoseisis patient, before test 1 week, carry out Continuous Observation, record symptom and change, be divided into four groups at random, often organize 40 people this crowd.

First group of medicated powder using object lesson 1 of the present invention.

Second group uses each feeding 5g of background technology 201010585693.7 teeth consolidating hair color toothpaste.

3rd group uses background technology 201210276722.0 for the oral liquid of odontoseisis, each 5ml.

The 4th group of herb liquid using background technology 201410430289.0 to control odontoseisis pain, each 5ml.

Sum up the tooth mobility before and after patient treatment and clinical therapeutic efficacy.Tooth mobility checks that the inspection method of basis " prosthetic dentistry " defined and standard are carried out, i.e. 0, I, II, III classification method.

Clinical efficacy is divided into:

1. effective: gingiva NIP, can sting hard thing, depth of pocket≤2, X-ray film display alveolar bone hardboard becomes clear, inostosis or densification, loosens without recurrent;

2. effective: gingiva, without obvious congested swelling, can sting medium hardness food, depth of pocket 2 ~ 4, X-ray film display alveolar bone is unchanged, without significantly recurrence is loosening;

3. invalid: before and after treatment, clinical symptoms is not improved or increases the weight of.

Result is as shown in table 1.

Table 1:

Group	Case load	Efficiently individual quantity	Effective number	Invalid number	Recurrence number	Obvious effective rate	Total effective rate
								First group	40	37	36	3	1	90%	92.5%
Second group	40	28	20	12	8	50%	70%
								3rd group	40	32	28	8	4	70%	80%
4th group	40	21	12	19	9	30%	52.5%

The present invention with eliminating stomach-fire to Gypsum Fibrosum, Fructus Forsythiae, clearing stomach the turbid descending be monarch drug to medicine Rhizoma Coptidis, the Rhizoma Pinelliae.With clearing stomach promote the production of body fluid to medicine Rhizoma Cimicifugae, the Radix Rehmanniae, stomach warming and blood to web Piao, Radix Angelicae Sinensis, QI invigorating nourishing the stomach to medicine Radix Ginseng, Folium Bambusae, dyspepsia and intestinal stasis relieving to Fructus Crataegi, Massa Medicata Fermentata ministerial drug.With the Radix Angelicae Dahuricae of reducing swelling and alleviating pain, the Herba Asari of dispelling wind and relieving pain, heat-clearing and toxic substances removing removes the Radix Sophorae Tonkinensis of gingival swelling and pain, dispelling wind and heat pathogens removes the Flos Eriocauli of having a toothache, the Radix Et Rhizoma Nardostachyos of promoting the circulation of QI to relieve pain, continuous muscle of invigorating blood circulation, the Rhizoma Drynariae of Psoralen bone strengthening, warming the meridian for stopping bleeding, the Folium Artemisiae Argyi of dispersing cold for relieving pain, heat-clearing and toxic substances removing, the Caulis Sargentodoxae of promoting blood circulation and stopping pain, removing toxic substances goes the Chalcanthitum (Chalcanthitum is poisonous, and consumption is little) of having a toothache to be adjuvant drug, with Radix Glycyrrhizae for making medicine.Proportioning of the present invention is simple, easy to use, eliminating stomach-fire, teeth consolidating antiinflammatory, evident in efficacy to odontoseisis caused by the stomach fire second of the three ten-day periods of the hot season.

Claims (3)

1. be used for the treatment of a Chinese medicine composition for odontoseisis caused by the stomach fire second of the three ten-day periods of the hot season, it is characterized in that, according to the following each component of unit of weight configuration:

Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 40-60g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 20-40g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 10-20g of Caulis Sargentodoxae, Chalcanthitum 5-10g, Radix Glycyrrhizae 10-20g.

2. be used for the treatment of the Chinese medicine composition of odontoseisis caused by the stomach fire second of the three ten-day periods of the hot season according to claim 1, it is characterized in that, according to the following each component of unit of weight configuration:

Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 40-50g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 20-30g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 10-15g of Caulis Sargentodoxae, Chalcanthitum 5-8g, Radix Glycyrrhizae 10-15g.

3. be used for the treatment of the Chinese medicine composition of odontoseisis caused by the stomach fire second of the three ten-day periods of the hot season according to claim 1, it is characterized in that, according to the following each component of unit of weight configuration:

Gypsum Fibrosum, Fructus Forsythiae, Rhizoma Coptidis, each 50-60g of the Rhizoma Pinelliae, Rhizoma Cimicifugae, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis, Radix Ginseng, Folium Bambusae, Fructus Crataegi, each 30-40g of Massa Medicata Fermentata, the Radix Angelicae Dahuricae, Herba Asari, Radix Sophorae Tonkinensis, Flos Eriocauli, Radix Et Rhizoma Nardostachyos, Rhizoma Drynariae, Folium Artemisiae Argyi, each 15-20g of Caulis Sargentodoxae, Chalcanthitum 8-10g, Radix Glycyrrhizae 15-20g.