CN105266153B - A kind of anti-oxidation health piece and preparation method thereof - Google Patents
A kind of anti-oxidation health piece and preparation method thereof Download PDFInfo
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- CN105266153B CN105266153B CN201510755112.2A CN201510755112A CN105266153B CN 105266153 B CN105266153 B CN 105266153B CN 201510755112 A CN201510755112 A CN 201510755112A CN 105266153 B CN105266153 B CN 105266153B
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of anti-oxidation health piece, which includes the following raw material by weight：5 20 parts of Cranberry extract, 0.5 8 parts of grape seed extract, 0.5 8 parts of Punica granatum L. extract, 0.1 5 parts of olive polyphenol, 0.1 5 parts of nostoc powder.The preparation method of anti-oxidation health piece of the present invention includes the following steps：Cranberry extract, grape seed extract, Punica granatum L. extract, olive polyphenol and nostoc powder are weighed by weight, are crossed 60 100 mesh sieve, are mixed well, obtain mixture；Weigh excipient, disintegrant, lubricant by weight and be added in said mixture, then mix well, by obtained mixed powder direct tablet compressing to get.The anti-oxidation health piece of the present invention has stronger antioxidation, can conspicuousness improve serum superoxide dismutases SOD, Agifutol peroxidase GSH PX vigor and conspicuousness and reduce the malonaldehyde MDA contents of serum.
Description
Technical field
The present invention relates to technical field of health care food, it is more particularly to a kind of anti-oxidation health piece and preparation method thereof.
Background technology
Modern medicine believes that, the one of the major reasons of people's aging are bodies while carrying out a series of oxidative metabolisms, no
It generates free radicals disconnectedly, superfluous free radical may act on the lipid materials such as blood, cell, tissue, it is made to become lipid peroxy
Compound, these peroxide, which are deposited on cell membrane, makes cell membrane loss of function, and cell viability is caused to decline, tissue organ function
Decline, body enters aging state, and induces atherosclerosis, coronary heart disease, cerebral apoplexy, hypertension, diabetes, old silly
The diseases such as slow-witted, Parkinson's disease, malignant tumour.Studies have shown that lipid peroxidation caused by free radical is in Histopathological lesions process
In play a very important role, and the degree of cellular damage can be adjusted by Antioxidation Mechanism.Therefore, appropriate supplement is anti-
To improving, antioxidant ability of organism, enhancement body health level, reduction disease risks, slow down aging has important meaning to oxidant
Justice.
Continuous improvement with the mankind to own health degree of concern, the health care food that research and development are beneficial to man healthy
Product have become the key issues of the fields scientific research personnel such as food and medicine research.In view of lipid peroxidation caused by free radical
It is played a very important role during Histopathological lesions, it is anti-oxidant to have become anti-aging, treat the important of disease
One of measure.Anti-oxidant is exactly effectively to remove internal harmful free radicals, prevents lipid peroxidation, prevents free radical to biological big point
The oxidative damage of son, ensures the normal of cellular structures and functions.Especially for multi-component antioxidant action mechanism and effect
Fruit evaluation study has a large amount of need of work to complete, and correlative study needs further deeply.
Modern medicine proves that occurrence and development and the oxidative damage of a variety of diseases have substantial connection.The eighties, free radical is to strong
The influence of health is increasingly recognized by people, and modern medicine and nutrition and health care think, free radical can directly cause to be permitted in human body
More diseases.It is significant to promote body health level to improving antioxidant ability of organism for appropriate supplement antioxidant.Study table
Bright, the diseases such as peroxidating and tumour, diabetes, angiocardiopathy, senile dementia are closely related, and anti-oxidant preventable disease prolongs
Slow aging.For a long time, it is always hot spot of people's attention that health care approach, which achievees the purpose that promote longevity, through diet.
Invention content
(1) technical problems to be solved
The technical problem to be solved in the present invention is to how make human body anti-oxidant, prevent disease, slow down aging, and provides one
Kind anti-oxidation health piece and preparation method thereof.
(2) technical solution
In order to solve the above technical problem, the present invention provides a kind of anti-oxidation health pieces, and the anti-oxidation health piece is by weight
It includes the following raw material to measure part meter：5-20 parts of Cranberry extract (is purchased from French Lai Kerui companies), 0.5-8 parts of grape seed extract
(being purchased from French Lai Kerui companies), 0.5-8 parts of Punica granatum L. extract (are purchased from French Lai Kerui companies), (purchase of 0.1-5 parts of olive polyphenol
In French Lai Kerui companies), nostoc powder 0.1-5 parts (self-produced).
Preferably, the anti-oxidation health piece includes the following raw material by weight：10-15 parts of Cranberry extract, Portugal
1-5 parts of grape seed extract, 1-5 parts of Punica granatum L. extract, 0.5-3 parts of olive polyphenol, 0.5-3 parts of nostoc powder.
Preferably, the anti-oxidation health piece includes the following raw material by weight：12 parts of Cranberry extract, grape pip
2 parts of extract, 2 parts of Punica granatum L. extract, 1 part of olive polyphenol, 1 part of nostoc powder.
Preferably, the anti-oxidation health piece further includes the following raw material by weight：8-36 parts of excipient, disintegrant
0.2-0.5 parts, 0.3-0.6 parts of lubricant.
Preferably, the excipient choose antierythrite, lactose, xylitol, mannitol or one kind in oligofructose or
It is several；Preferably antierythrite.
Preferably, the disintegrant chooses sodium carboxymethylcellulose, low-substituted hydroxypropyl cellulose, crosslinked polyethylene pyrroles
One or more of alkanone, sodium carboxymethyl starch；Preferably sodium carboxymethyl starch.
Preferably, the lubricant chooses one or more of stearic acid, magnesium stearate or calcium stearate；It is preferably hard
Fatty acid magnesium.
Preferably, the anti-oxidation health piece includes the following raw material by weight：10-15 parts of Cranberry extract, Portugal
1-5 parts of grape seed extract, 1-5 parts of Punica granatum L. extract, 0.5-3 parts of olive polyphenol, 0.5-3 parts of nostoc powder, antierythrite 8-36
Part, 0.2-0.5 parts of sodium carboxymethyl starch, 0.3-0.6 parts of magnesium stearate.
Preferably, the anti-oxidation health piece includes the following raw material by weight：12 parts of Cranberry extract, grape pip
2 parts of extract, 2 parts of Punica granatum L. extract, 1 part of olive polyphenol, 1 part of nostoc powder, 18 parts of antierythrite, sodium carboxymethyl starch 0.4
Part, 0.4 part of magnesium stearate.
The present invention also provides the preparation methods of above-mentioned anti-oxidation health piece, and this method comprises the following steps：By weight
Cranberry extract extract, grape seed extract, Punica granatum L. extract, olive polyphenol and nostoc powder are weighed, 60-100 mesh is crossed
Sieve, mixes well, obtains mixture；Antierythrite, sodium carboxymethyl starch and magnesium stearate are weighed by weight and are added to
State in mixture, then mix well, by obtained mixed powder direct tablet compressing to get.
(3) advantageous effect
The anti-oxidation health piece of the present invention has stronger antioxidation, being capable of conspicuousness raising serum superoxides discrimination
Changing enzyme SOD, Agifutol peroxidase GSH-PX vigor and conspicuousness reduces the malonaldehyde MDA contents of serum.The present invention is anti-
Oxidation health-care tablet also has the function of reducing blood lipid, prevents liver and coronary atherosclerosis, can play reduction or keep blood
Press stable effect.It is raw materials used without sucrose, suitable diabetic takes.Anti-oxidation health piece of the present invention is using dry simultaneously
The mode tabletting of powder vertical compression, simple production process are suitble to industrialized requirement.
Specific implementation mode
Embodiments of the present invention are described in further detail with reference to embodiment.Following embodiment is for illustrating this
Invention, but cannot be used for limiting the scope of the invention.
Flavone compound in Cranberry extract in vivo, have anti-oxidation function in experiment in vitro, it is especially yellow
Keto-alcohol and procyanidine have prevention effect to atherosclerosis.This kind of compound can inhibit low density lipoprotein white (LDL) oxidation
And platelet aggregation and adherency, inhibit the enzyme in lipid and lipoprotein metabolism；Regulate and control the immune response of LDL oxidations, increases courage
The antiport of sterol reduces total cholesterol and LDL- cholesterol.Procyanidine (a kind of biology being rich in Cranberry extract
Flavonoids), it is the generally acknowledged in the world most effective natural of removing human free radical, Green Tea Extract oxidability is
50 times of VE.Flavonoids in Cranberry extract can reduce blood plasma lipoprotein level, inhibit LDL oxidations, increase blood plasma antioxygen
Change ability, it has been found that Cranberry extract has antioxygenic property, improves the oxidation resistance in blood plasma, protects red blood cell anti-hemolysis
With cellular anti-oxidant activity.
The main functional component of grape seed extract is procyanidine, domestic and international various experiment in vitro and animal experiment study
It confirms, grape seed extract proanthocyanidin has very strong antioxidant activity, is a kind of good oxygen free radical scavenger and fat
Matter peroxidating inhibitor, can play a protective role to oxidative damage, and its protective effect is better than other antioxidants.In addition, former
Anthocyanidin also has the physiological functions such as anticancer, antifatigue.
Pomegranate has powerful antioxidation, and juice of my pomegranate, granatum and granada seed oil contain micro estrogen
For the treatment of menopausal syndrome and its sequelae, also there is anti-cancer efficacy, including inhibit tumor cell proliferation, inhibit tumour
Cell cycle, inhibit tumour cell invasion and inhibit tumour cell angiogenesis the effects that.Containing a large amount of with anti-in pomegranate
The flavone compound of oxidation.In recent years, tentatively research of the expansion pomegranate at anti-oxidant aspect both at home and abroad.As a result
It has been shown that, Punica granatum L. extract can effectively remove light free radical and ultra-oxygen anion free radical, inhibit LDL and lipid peroxidation,
Inhibit the formation of atherosclerosis (AS), there is very strong anti-oxidation function.Inhibit through free radical ability and removes oxygen freedom
Base ability enhances.And it is comparable in Punica granatum L. polyphenol and grape procyanidins concentration, the inhibition of juice of my pomegranate is through free radical ability and clear
Except oxygen radical ability is better than grape procyanidins.Therefore juice of my pomegranate can reduce free radical in human body as a kind of free radical inhibitors
The harm of middle generation.
Olive is exactly the common Chinese medicine in China from ancient times, has unique pharmacological effect, on China's multi-section Chinese medicine ancient books and records
It is on the books, have it is clearing heat and detoxicating, relieving sore-throat resolving sputum promotes the production of body fluid to quench thirst, clearing and activating the channels and collaterals, dispelling wind and eliminating dampness, liver protecting, treat sheep epilepsy
Wind, removing toxic substances and other effects, in recent years research shows that olive also have anticancer, anti-hepatitis virus, inhibit blood glucose rising, fat-reducing slimming,
The effects that antibacterial.Contain relatively rich aldehydes matter in olive, olive polyphenol has hydroxyl radical free radical, nitrite stronger clear
Except effect, there is stronger antioxidation, and apparent antitumor, antiviral, antimicrobial, anti-aging, antibacterial and suppression
Cholesterol rising processed and other effects, absorbing a certain amount of olive polyphenol effectively can prevent and inhibit the generation of disease.
Nostoc is with a long history in China, is not only one of traditional delicacies full of nutrition, and have higher medical treatment
And health-care efficacy.According to records, nostoc has treatment yctalopia, rectal prolapse the effect of scalding and have both beauty, in addition also to have improving eyesight
QI invigorating, sharp stomach, eats macrobiosis, dispelling fatigue, convergence and other effects at antipyretic clear diaphragm long.
It is further illustrated the present invention below with embodiment.
Embodiment 1
A kind of anti-oxidation health piece is present embodiments provided, which includes the following raw material by weight：It is climing to get over
Certain kind of berries extract 12g, grape seed extract 2g, Punica granatum L. extract 2g, olive polyphenol 1g, nostoc powder 1g, antierythrite 18g, carboxylic
Methyl starch sodium 0.4g, magnesium stearate 0.4g.
The anti-oxidation health piece preparation method is as follows：Weigh Cranberry extract, grape seed extract, Punica granatum L. extract,
Olive polyphenol, nostoc powder are crossed 80 mesh sieve, are uniformly mixed；Weigh antierythrite, sodium carboxymethyl starch, magnesium stearate, in addition
Uniformly mixing again in mixture is stated, with dry powder sheeting machine direct pressing piece agent.
Embodiment 2
A kind of anti-oxidation health piece is present embodiments provided, which includes the following raw material by weight：It is climing to get over
Certain kind of berries extract 10g, grape seed extract 1g, Punica granatum L. extract 1g, olive polyphenol 0.5g, nostoc powder 0.5g, lactose 8g, carboxylic first
Base sodium cellulosate 0.2g, stearic acid 0.3g.
The anti-oxidation health piece preparation method is as follows：Weigh Cranberry extract, grape seed extract, Punica granatum L. extract,
Olive polyphenol, nostoc powder are crossed 60 mesh sieve, are uniformly mixed；Lactose, sodium carboxymethylcellulose are weighed, stearic acid is added above-mentioned mixed
It closes and is remixed in object uniformly, with dry powder sheeting machine direct pressing piece agent.
Embodiment 3
A kind of anti-oxidation health piece is present embodiments provided, which includes the following raw material by weight：It is climing to get over
Certain kind of berries extract 15g, grape seed extract 5g, Punica granatum L. extract 5g, olive polyphenol 3g, nostoc powder 3g, xylitol 36g are low to take
For hydroxypropyl cellulose 0.5g, calcium stearate 0.6g.
The anti-oxidation health piece preparation method is as follows：Weigh Cranberry extract, grape seed extract, Punica granatum L. extract,
Olive polyphenol, nostoc powder, sieves with 100 mesh sieve, and uniformly mixes；Weigh xylitol, low-substituted hydroxypropyl cellulose, calcium stearate,
It is added in said mixture and remixes uniformly, with dry powder sheeting machine direct pressing piece agent.
Embodiment 4
Compared with Example 1, distinctive points are only that, which includes the following raw material by weight：Cranberry carries
Take object 5g, grape seed extract 0.5g, Punica granatum L. extract 0.5g, olive polyphenol 0.1g, nostoc powder 0.1g.
Embodiment 5
Compared with Example 1, distinctive points are only that, which includes the following raw material by weight：Cranberry carries
Take object 20g, grape seed extract 8g, Punica granatum L. extract 8g, olive polyphenol 5g, nostoc powder 5g.
Embodiment 6
Compared with Example 1, distinctive points are only that, which includes the following raw material by weight：Cranberry carries
Take object 10g, grape seed extract 1g, Punica granatum L. extract 1g, olive polyphenol 0.5g, nostoc powder 0.5g, antierythrite 8g, carboxylic first
Base sodium starch 0.2g, magnesium stearate 0.3g.
Embodiment 7
Compared with Example 1, distinctive points are only that, which includes the following raw material by weight：Cranberry carries
Take object 15g, grape seed extract 5g, Punica granatum L. extract 5g, olive polyphenol 3g, nostoc powder 3g, antierythrite 36g, carboxymethyl
Sodium starch 0.5g, magnesium stearate 0.6g.
Test example 1：Zoopery：
Experiment purpose：Examine whether product has the function of oxidation-resisting health-care.
Experiment material：The anti-oxidation health piece obtained according to the formula of embodiment 1.
Experimental animal：Cleaning grade SD kind male two levels Kunming kind female mice 50, weight 18-22g, about 3 monthly ages.
Experimental situation condition：Barrier system, 22~24 DEG C of temperature, humidity 52~58%.
Dosage selects：This product human body day, recommended intake was 1.8g/60kgbw, if anti-oxidant basic, normal, high dosage difference
For 0.15g/kgbw, 0.3g/kgbw, 0.9g/kgbw (5,10,30 times that are respectively equivalent to human body recommended dose).It is anti-
Aoxidize piece distilled water wiring solution-forming, oral gavage, gavage amount 0.1ml/10gbw.Separately set D- galactolipin model control groups
And blank control group.
Key instrument and reagent：UV-1201 ultraviolet-uisible spectrophotometers, cryogenic freezing centrifuge, ultrasound homogenizer, water
Bath cabinet；Malonaldehyde (MDA) kit, superoxide dismutase (SOD) kit, Agifutol peroxidase (GSH-PX)
Kit, Coomassie brilliant blue protein determination kit.
Experimental method：Two level Kunming kind female mice 50 is taken, is randomly divided into 5 groups, in addition to blank control group, remaining animal
It is injected intraperitoneally modeling with D- galactolipins 500mg/kg.BW, injection volume 0.1ml/10g.bw, one time a day, continuous modeling 6 weeks,
Tail hematometry MDA contents are taken, are grouped by MDA levels.It is randomly divided into 1 model control group and 3 tested material groups, 3 dosage groups
The given the test agent of orally administration various concentration, model control group give isometric distilled water, while to given the test agent, model
Control group and each dosage group continue to give the D- galactolipins of same dose, continue 30 days.Liver is taken in experiment latter stage, it is even to be made 5%
Lipid peroxide content and antioxidase activity are measured after slurry.
Lipid peroxide (LPO) assay：Lipid peroxide catabolite malonaldehyde (MDA) is containing measurement in liver homogenate
It is fixed：MDA contents in 5% liver homogenate are measured by the requirement of kit.
Antioxidase activity measures：Superoxide dismutase (SOD) vitality test in liver homogenate：It is surveyed by the requirement of kit
SOD vigor in fixed 5% liver homogenate, and according to tissue protein content, by unit conversion at U/mgprot.
Agifutol peroxidase (GSH-PX) vitality test in liver homogenate：0.25% is measured by the requirement of kit
GSH-PX vigor in liver homogenate, and according to tissue protein content, by unit conversion at U/mgprot.
Tissue protein content measures：Histone in 1% liver homogenate is measured using Coomassie brilliant blue protein determination kit
Content.
Experimental result：
Experimental data carries out statistical check with SPSS10.0, and wherein blank control group is examined with model control group using T-,
Model control group is examined using variance analysis and two-by-two with each dosage group, if heterogeneity of variance person uses data conversion, after conversion still
It is uneven then to use nonparametric statistics.In D- galactolipin modeling zooperies, after anti-oxidant of orally administration various dose, respectively
Group growth of animal, activity are normal, and low, high dose group animal weightening is higher than Normal group, and the significant (P of difference<0.05).
The MDA contents of middle and high dosage group liver homogenate are below model control group, and the significant (P of difference<0.05)；Low, high dose group
The SOD vigor of liver homogenate is above model control group, and the significant (P of difference<0.05)；The GSH- of high dose group liver homogenate
PX vigor is higher than model control group, and the significant (P of difference<0.05).According to《Health food is examined and assessment technique specification》
(version in 2003), the anti-oxidation health piece have anti-oxidation function effect.
Specific experiment result data is as follows：
Table 1：The anti-oxidant influence to D- galactolipin modeling experiment mice weight
Table 2：MDA is horizontal after modeling grouping
Table 3：The anti-oxidant influence to MDA, SOD
Table 4：The anti-oxidant influence to GSH-PX
Test example 2：Human body foretastes experiment：
The selection criteria of subject：
Age, physical condition was good at 45 1 65 years old, without apparent brain, the heart, liver, lung, kidney, Hematological Diseases, without long-term
Medication history, aspiration is tested and ensures the middle-aged and the old of cooperation.
Subject Exclusion Criteria：
(1) gestation or women breast-feeding their children, to health products allergy sufferers.
(2) merge intentionally, liver, the serious diseases patient such as kidney and hemopoietic system.
(3) article related with tested function is taken in a short time, influences the judgement person to result.
(4) inclusion criteria is not met, does not use according to regulations given the test agent, can not judging effect or data, umbra does not ring effect
Or safety judgement person.
Research object is grouped：
Using itself, two kinds of control designs, 110 subjects are randomly divided into according to mono- PX, MDA level of SOD, GSH between group
Test-meal group (55 people) and control group (55 people).In view of the factor age and gender of result may be influenced in grouping process, and it is right
It carries out harmonious inspection, with the comparativity between guarantee group.
Experimental method：
Test-meal group takes given the test agent 2g/ days, i.e. 4/day, gives the time 3 months, and control group does not make any processing,
Test-meal group keeps life, diet constant with control group during test-meal.
Experimental result：
Human experimentation, can be notable the results show that the anti-oxidation health piece shows stronger antioxidation to human body
Property improve SOD in serum, GSH-PX vigor and conspicuousness reduce the MDA contents of serum.The fatigue, agitation of subject during edible,
The subjective symptoms such as poor sleep, soreness of waist and knee make moderate progress, and blood routine, routine urinalysis, just conventional and items blood biochemistry index are not
See exception) prove that its oxidation-resisting health-care function is definite, and harmful effect is not generated to subject's health), experimental result
It is shown in Table 5.
Table 5：The comparison of experiment front and back SOD, GSH-PX vigor, MDA contents
Embodiment of above is merely to illustrate the present invention rather than limitation of the present invention.Although with reference to embodiment to this hair
It is bright to be described in detail, it will be understood by those of ordinary skill in the art that, to technical scheme of the present invention carry out it is various combination,
Modification or equivalent replacement, without departure from the spirit and scope of technical solution of the present invention, the right that should all cover in the present invention is wanted
It asks in range.
Claims (9)
1. a kind of anti-oxidation health piece, which is characterized in that the anti-oxidation health piece is made of the raw material of following parts by weight：Cranberry
5-20 parts of extract, 0.5-8 parts of grape seed extract, 0.5-8 parts of Punica granatum L. extract, 0.1-5 parts of olive polyphenol, nostoc powder
0.1-5 parts, 8-36 parts of excipient, 0.2-0.5 parts of disintegrant, 0.3-0.6 parts of lubricant；
The excipient chooses one or more of antierythrite, lactose, xylitol, mannitol or oligofructose, described to collapse
Agent is solved to choose in sodium carboxymethylcellulose, low-substituted hydroxypropyl cellulose, crosslinked polyvinylpyrrolidone, sodium carboxymethyl starch
One or more, the lubricant choose one or more of stearic acid, magnesium stearate or calcium stearate.
2. anti-oxidation health piece according to claim 1, which is characterized in that the anti-oxidation health piece is by following parts by weight
Raw material composition：10-15 parts of Cranberry extract, 1-5 parts of grape seed extract, 1-5 parts of Punica granatum L. extract, olive polyphenol 0.5-
3 parts, 0.5-3 parts of nostoc powder, 8-36 parts of excipient, 0.2-0.5 parts of disintegrant, 0.3-0.6 parts of lubricant.
3. anti-oxidation health piece according to claim 1, which is characterized in that the anti-oxidation health piece is by following parts by weight
Raw material composition：12 parts of Cranberry extract, 2 parts of grape seed extract, 2 parts of Punica granatum L. extract, 1 part of olive polyphenol, nostoc
1 part of powder, 8-36 parts of excipient, 0.2-0.5 parts of disintegrant, 0.3-0.6 parts of lubricant.
4. anti-oxidation health piece according to claim 1, which is characterized in that the excipient is antierythrite.
5. anti-oxidation health piece according to claim 1, which is characterized in that the disintegrant is sodium carboxymethyl starch.
6. anti-oxidation health piece according to claim 1, which is characterized in that the lubricant is magnesium stearate.
7. according to claim 1-2,4-6 any one of them anti-oxidation health piece, which is characterized in that the anti-oxidation health piece
It is made of the raw material of following parts by weight：10-15 parts of Cranberry extract, 1-5 parts of grape seed extract, 1-5 parts of Punica granatum L. extract,
0.5-3 parts of olive polyphenol, 0.5-3 parts of nostoc powder, 8-36 parts of antierythrite, 0.2-0.5 parts of sodium carboxymethyl starch, magnesium stearate
0.3-0.6 parts.
8. anti-oxidation health piece according to claim 7, which is characterized in that the anti-oxidation health piece is by following parts by weight
Raw material composition：12 parts of Cranberry extract, 2 parts of grape seed extract, 2 parts of Punica granatum L. extract, 1 part of olive polyphenol, nostoc
1 part of powder, 18 parts of antierythrite, 0.4 part of sodium carboxymethyl starch, 0.4 part of magnesium stearate.
9. the preparation method of claim 1-6 any one of them anti-oxidation health pieces, which is characterized in that this method includes as follows
Step：Cranberry extract, grape seed extract, Punica granatum L. extract, olive polyphenol and nostoc powder, mistake are weighed by weight
60-100 mesh sieves, and mixes well, obtains mixture；Antierythrite, sodium carboxymethyl starch and magnesium stearate are weighed by weight simultaneously
Be added in said mixture, then mix well, by obtained mixed powder direct tablet compressing to get.
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| WO2010014846A1 (en) * | 2008-07-30 | 2010-02-04 | T & T Enterprises Inc. | Antioxidant additive |
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| WO2010014846A1 (en) * | 2008-07-30 | 2010-02-04 | T & T Enterprises Inc. | Antioxidant additive |
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