CN104970371A - Health-care food with antioxidant function - Google Patents
Health-care food with antioxidant function Download PDFInfo
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- CN104970371A CN104970371A CN201510381908.6A CN201510381908A CN104970371A CN 104970371 A CN104970371 A CN 104970371A CN 201510381908 A CN201510381908 A CN 201510381908A CN 104970371 A CN104970371 A CN 104970371A
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- 239000002994 raw material Substances 0.000 claims abstract description 13
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a health-care food with an antioxidant function. The health-care food comprises the following raw materials in parts by weight: 1-35 parts of grape seed extracts, 1-50 parts of green tea extracts, 1-50 parts of radix salviae miltiorrhizae extracts, 1-60 parts of astragalus extracts, and 0.001-0.01 part of natural VE. The health-care food with the antioxidant function, which is provided by the invention, can directly or indirectly clear away various free radicals in human bodies, can delay senescence, and can prevent cardiovascular and cerebrovascular diseases from generation. According to the health-care food provided by the invention, the modern pharmacology and pharmacodynamics are combined with the traditional Chinese pharmacology, and natural extracts are finely selected, so that the health-care food is safe and free from toxicity.
Description
Technical field
The present invention relates to technical field of health care food, specifically, relate to a kind of health food with anti-oxidation function.
Background technology
Body constantly produces active oxygen radical in metabolic process, also be constantly eliminated simultaneously, free radical is in and constantly produces with the dynamic equilibrium of removing, body is made to maintain the physiological free-radical contents gained everything and lose nothing, but excessive free radicals can cause body cell non-specific oxidation to damage, thus cause various disease, as nearly all relevant with radical metabolism in aging, cardiovascular and cerebrovascular disease, cancer, diabetes etc.Free radical infringement vascular wall, causes the oxidation of LDL-C to be then the chief culprit of all angiocardiopathies.Research is pointed out, free radical is one of arch-criminal forming atherosclerotic and cardiovascular and cerebrovascular disease, very easily forms blood vessel blockage, vascular endothelial cell injury, makes blood fat infiltrate endangium, forms congee sample lump, the elasticity of blood vessel is reduced, causes angiorrhoxis.
In the various diseases of the mankind, more than 90% originates from active oxygen and oxidative stress, the object of Effect of Anti oxidation, wish by many-sided research and screening exactly, final energy is a kind of available to people, and antioxidation is clear and definite, and the preparation that security is very good.Although the antioxidant oxidation resistance of conventional synthesis is stronger, long-term eating has potential toxicity, and what have even can produce teratogenesis, carcinogenesis.Along with new Antioxidation Mechanism is constantly found, people more and more trend towards applying natural antioxidant.China has abundant Chinese herbal medicine resource, their drug effect and security clear and definite.Therefore, find natural, efficient Chinese herbal medicine antioxidant and become a kind of inexorable trend.
Summary of the invention
The object of this invention is to provide one and there is antioxidant functional food; Described health food, except having anti-oxidation function, also has health-care effects such as delaying body aging, reducing blood lipid, prevention cardiovascular and cerebrovascular disease.
In order to realize the object of the invention, first the present invention provides a kind of composition with anti-oxidation function, comprises the raw material of following weight portion: grape seed extract 1 ~ 35 part, green-tea extract 1 ~ 50 part, Salvia root P.E 1 ~ 50 part, Astragalus Root P.E 1 ~ 60 part, VE 0.001 ~ 0.01 part.
Preferably, the composition described in anti-oxidation function comprises the raw material of following weight portion: grape seed extract 5 ~ 30 parts, green-tea extract 5 ~ 45 parts, Salvia root P.E 5 ~ 40 parts, Astragalus Root P.E 5 ~ 50 parts, VE 0.002 ~ 0.008 part.
Further preferably, the composition described in anti-oxidation function comprises the raw material of following weight portion: grape seed extract 15 ~ 20 parts, green-tea extract 30 ~ 40 parts, Salvia root P.E 20 ~ 30 parts, Astragalus Root P.E 10 ~ 35 parts, VE 0.003 ~ 0.006 part.
More preferably, the composition described in anti-oxidation function comprises the raw material of following weight portion: grape seed extract 20 parts, green-tea extract 40 parts, Salvia root P.E 20 parts, Astragalus Root P.E 20 parts, VE 0.006 part.
As preferably, described grape seed extract its preparation method comprises alcohol extract, concentrated, spraying dry, wherein procyanidin content >=95%; Can be buied by market, also can conventionally prepare voluntarily.
As preferably, described green-tea extract its preparation method comprises that water extraction is got, concentrated, spraying dry, wherein polyphenol content >=90%; Can be buied by market, also can conventionally prepare voluntarily.
As preferably, described Salvia root P.E its preparation method comprises that water extraction is got, concentrated, spraying dry, wherein content of danshinolic acid B >=10%; Can be buied by market, also can conventionally as version Chinese Pharmacopoeia method in 2010 be prepared voluntarily.
As preferably, described Astragalus Root P.E its preparation method comprises that water extraction is got, concentrated, spraying dry, wherein Astragaloside content >=0.3%; Can be buied by market, also can conventionally as version Chinese Pharmacopoeia method in 2010 be prepared voluntarily.
Described VE and vitamin E, be preferably natural VE.
The composition with anti-oxidation function of the present invention can technology be prepared from routinely; Preferably, the preparation method of composition described in anti-oxidation function comprises the step that each composition is sieved and mixed.
The composition described in the present invention also comprises with anti-oxidation function is preparing the application had in the health food of anti-oxidation function.
The present invention also provides a kind of health food with anti-oxidation function, containing the above-mentioned composition with anti-oxidation function.
The health food with anti-oxidation function of the present invention also contains the auxiliary material etc. food allowing use; Described auxiliary material include but not limited to standard GB/T 2760 allow the food additives that use and meet the health food supplementary material etc. that state's laws specify.
The health food with anti-oxidation function of the present invention can make the formulations such as tablet, granule, capsule by art methods.
Weight portion of the present invention can be the known unit of weights of field of food such as μ g, mg, g, kg, also can be its multiple, as 1/10,1/100,10 times, 100 times etc.
As preferably, the present invention also provide a kind of described in there is the preparation method of the health food of anti-oxidation function, comprise the following steps: get grape seed extract, green-tea extract, Salvia root P.E, Astragalus Root P.E, VE, interpolation maltodextrin, microcrystalline cellulose mix and obtain according to a conventional method; Such as add ethanol in proper amount solution softwood, 16 mesh sieves are granulated, and 60 to 70 DEG C of dryings, the whole grain of 12 mesh sieve obtains granule.
It is active that Tea Polyphenols in grape pip in anthocyanidin and green tea all can improve SOD, CAT, reduce the generation of lipid peroxidation product MDA, be equipped with natural VE again, the combination of water-soluble and oil-soluble polyphenoils, can significantly improve superoxide anion, hydroxyl radical free radical, nitric oxide free radical, H
2o
2and the elimination effect of the free radical such as unsaturated fat acid oxidation product, suppress the occurrence and harm of cardiovascular and cerebrovascular disease.The traditional Chinese medical science to cardiovascular and cerebrovascular diseases show because of hematogenous blockage, extravasated blood internal resistance and syndrome that the cardiac and cerebral blood-supply that causes reduces all adopts stasis, to increase the blood supply of the organs such as heart and brain, red sage root tool is promoting blood circulation and removing blood stasis, swelling and pain relieving, nourishing blood and tranquilization effect, the traditional treatment key agents that a lump in the abdomen causing distension and pain, abdominal pain due to blood stasis, palpitaition are pained, the most frequently used medicine of modern TCM control cardiovascular and cerebrovascular disease especially; Positive unsaturated vapor, negative and positive loss be disease this, therefore preventing and treating cardiovascular and cerebrovascular diseases can not be promoting blood circulation and removing blood stasis merely, must be combined with righting qi-restoratives method, and Compatibility with Radix Astragali hits etiology and pathogenesis, can obtain good effect.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.If do not specialize, the conventional means that technological means used in embodiment is well known to those skilled in the art, is raw materials usedly commercial goods.
Grape seed extract is purchased from Jianfeng Natural Product R&D Development Co., Ltd., Tianjin, and procyanidin content is 95%; Green-tea extract is purchased from Wuxi Taiyo Green Power Co., Ltd., and polyphenol content is 90%; Salvia root P.E, Astragalus Root P.E are purchased from Ningbo Liwah Plant Extract Technology Co., Ltd., and in Salvia root P.E, content of danshinolic acid B is 10%, Astragloside IV in Extraction of Radix Astragali content is 0.3%; Vitamin E is purchased from Di Si Man.
Embodiment 1
There is a health food for anti-oxidation function, be prepared from by following component: grape seed extract 20kg, green-tea extract 40kg, Salvia root P.E 20kg, Astragalus Root P.E 20kg, natural VE 0.006kg.By said components routinely technology make capsule.
Embodiment 2
There is a health food for anti-oxidation function, be prepared from by following component: grape seed extract 15kg, green-tea extract 30kg, Salvia root P.E 20kg, Astragalus Root P.E 35kg, natural VE 0.006kg.By said components routinely technology make capsule.
Embodiment 3
There is a health food for anti-oxidation function, be prepared from by following component: grape seed extract 15kg, green-tea extract 30kg, Salvia root P.E 30kg, Astragalus Root P.E 25kg, natural VE 0.006kg.By said components routinely technology make capsule.
Embodiment 4
There is a health food for anti-oxidation function, be prepared from by following component: grape seed extract 20kg, green-tea extract 40kg, Salvia root P.E 30kg, Astragalus Root P.E 10kg, natural VE 0.003kg.By said components routinely technology make capsule.
Embodiment 5
There is a composition for anti-oxidation function, be prepared from by following component: grape seed extract 20kg, green-tea extract 40kg, Salvia root P.E 20kg, Astragalus Root P.E 20kg, natural VE 0.006kg.
Embodiment 6
There is a composition for anti-oxidation function, be prepared from by following component: grape seed extract 15kg, green-tea extract 30kg, Salvia root P.E 20kg, Astragalus Root P.E 35kg, natural VE 0.006kg.
Embodiment 7
There is a composition for anti-oxidation function, be prepared from by following component: grape seed extract 15kg, green-tea extract 30kg, Salvia root P.E 30kg, Astragalus Root P.E 25kg, natural VE 0.006kg.
Embodiment 8
There is a composition for anti-oxidation function, be prepared from by following component: grape seed extract 20kg, green-tea extract 40kg, Salvia root P.E 30kg, Astragalus Root P.E 10kg, natural VE 0.003kg.
Embodiment 9
There is a composition for anti-oxidation function, comprise the raw material of following weight portion: grape seed extract 1kg, green-tea extract 50kg, Salvia root P.E 40kg, Astragalus Root P.E 60kg, natural VE 0.001kg.
Embodiment 10
There is a health food for anti-oxidation function, for by the granule made of technology routinely of the composition described in embodiment 9.
Embodiment 11
There is a composition for anti-oxidation function, comprise the raw material of following weight portion: grape seed extract 35kg, green-tea extract 1kg, Salvia root P.E 5kg, Astragalus Root P.E 1kg, VE0.01kg.
Embodiment 12
There is a health food for anti-oxidation function, for by the tablet made of technology routinely of the composition described in embodiment 11.
Embodiment 13
There is a composition for anti-oxidation function, comprise the raw material of following weight portion: grape seed extract 5kg, green-tea extract 45kg, Salvia root P.E 10kg, Astragalus Root P.E 50kg, VE 0.005kg.
Embodiment 14
There is a health food for anti-oxidation function, for by the capsule made of technology routinely of the composition described in embodiment 13.
Embodiment 15
There is a composition for anti-oxidation function, be prepared from by following active component: grape seed extract 30kg, green-tea extract 5kg, Salvia root P.E 50kg, Astragalus Root P.E 5kg, natural VE 0.008kg.
Embodiment 16
There is a health food for anti-oxidation function, for by the capsule made of technology routinely of the composition described in embodiment 15.
Embodiment 17
There is a composition for anti-oxidation function, be prepared from by following active component: grape seed extract 5kg, green-tea extract 5kg, Salvia root P.E 5kg, Astragalus Root P.E 5kg, natural VE 0.005kg.
Embodiment 18
There is a health food for anti-oxidation function, for by the granule made of technology routinely of the composition described in embodiment 17.
Embodiment 19
There is a composition for anti-oxidation function, be prepared from by following active component: grape seed extract 30kg, green-tea extract 45kg, Salvia root P.E 40kg, Astragalus Root P.E 50kg, natural VE 0.008kg.
Embodiment 20
There is a health food for anti-oxidation function, for by the tablet made of technology routinely of the composition described in embodiment 19.
Embodiment 21
A kind of preparation method with the health food of anti-oxidation function, formula is with embodiment 1, described preparation method comprises the following steps: get grape seed extract 20kg, green-tea extract 40kg, Salvia root P.E 20kg, Astragalus Root P.E 20kg, natural VE 0.006kg, add maltodextrin 13.28kg, microcrystalline cellulose 53.12kg, mix, add ethanol in proper amount solution softwood, 16 mesh sieves are granulated, 70 DEG C of dryings, the whole grain of 12 mesh sieve and get final product.
Embodiment 22
A kind of preparation method with the health food of anti-oxidation function, formula is with embodiment 2, described preparation method comprises the following steps: get grape seed extract 15kg, green-tea extract 30kg, Salvia root P.E 20kg, Astragalus Root P.E 35kg, natural VE 0.006kg, add maltodextrin 13.28kg, microcrystalline cellulose 53.12kg, mix, add ethanol in proper amount solution softwood, 16 mesh sieves are granulated, 60 DEG C of dryings, the whole grain of 12 mesh sieve and get final product.
Embodiment 23
A kind of preparation method with the health food of anti-oxidation function, formula is with embodiment 3, described preparation method comprises the following steps: get grape seed extract 15kg, green-tea extract 30kg, Salvia root P.E 30kg, Astragalus Root P.E 25kg, natural VE 0.006kg, add maltodextrin 13.28kg, microcrystalline cellulose 53.12kg, mix, add ethanol in proper amount solution softwood, 16 mesh sieves are granulated, 70 DEG C of dryings, the whole grain of 12 mesh sieve and get final product.
Embodiment 24
A kind of preparation method with the health food of anti-oxidation function, formula is with embodiment 4, described preparation method comprises the following steps: get grape seed extract 20kg, green-tea extract 40kg, Salvia root P.E 30kg, Astragalus Root P.E 10kg, natural VE 0.003kg, add maltodextrin 13.28kg, microcrystalline cellulose 53.12kg, mix, add ethanol in proper amount solution softwood, 16 mesh sieves are granulated, 60 DEG C of dryings, the whole grain of 12 mesh sieve and get final product.
Experimental example 1 oxidation resistance is tested
1.1 animals used as test and grouping
Kun Ming mice 110, is purchased from Beijing University of Chinese Medicine, 9 week age, male, and body weight 20g ± 2g, is divided into 11 groups at random, often organizes 10.Except blank group, all the other 10 groups with D-galactolipin 100mg/kg neck dorsal sc injection or lumbar injection modeling, injection volume is 0.1mL/10g, every day 1 time, continuous modeling 6 weeks.
1.2 experimental technique
Blank group and negative control group gavage physiological saline; Experimental group S1-S4 is the health food with anti-oxidation function prepared of gavage embodiment 1-4 respectively; Positive controls D1-D2 is gavage grape seed extract and green-tea extract respectively; Positive controls D3-D5 is gavage mixed extract H1 (grape seed extract and green-tea extract weight ratio are 1: 1), mixed extract H2 (grape seed extract, Salvia root P.E, Astragalus Root P.E three weight ratio are 1: 1: 1) and mixed extract H3 (green-tea extract, Salvia root P.E, Astragalus Root P.E three weight ratio are 1: 1: 1) respectively.Experiment grouping, gavage material and dosage are as shown in table 1 below.Continuous gavage 60 days, once a day, experiment terminates to put to death animal, detects mouse core tissue homogenate SOD (superoxide dismutase) vigor, brain tissue homogenate GSH-Px (glutathione peroxidase) vigor and heart MDA (MDA) content.
Table 1
1.3 experimental result
1.3.1 comparatively blank group, negative control group mouse core MDA (MDA) content significantly increases (P<0.05), and exhausted mining areas modeling success is described.
1.3.2 relative to negative control group, experimental group S1-S4 mouse core tissue homogenate SOD (superoxide dismutase) vigor, brain tissue homogenate GSH-Px (glutathione peroxidase) vigor significantly improve (P<0.05), heart MDA (MDA) content significantly reduces (P<0.05), experimental group S1 most pronounced effects.And experimental group S1-S4 antioxidant effect is more better than positive controls D1-D5, each component of illustrative experiment group has played the effect of Synergistic.
1.3.3 above result shows that antioxidant health-care product of the present invention has good anti-aging effects, and its effect delayed senility realizes by removing interior free yl.
Experimental example 2 lipid-lowering test
1.1 experimental technique
1.1.1 hyperlipidemia model: get 60 adult healthy male rats, feed high lipid food (basal feed 78.6%, yolk powder 10%, cholesterol 1%, cholate 0.2%, lard 10%, Frentirox sheet 0.2%) 30d, every day freely drinks water and searches for food, after 30d, water is can't help in fasting, after 12h, tail vein blood surveys serum lipid concentrations, detects qualified rear as hyperlipidemia model.
1.1.2 experiment grouping and method: high blood lipid model rat 60 is divided into 6 groups at random, often organizes 10.The wherein experimental group S1-S4 health food with anti-oxidation function prepared of gavage embodiment 1-4 respectively, dosage is 0.8g/d; Negative control group gavage physiological saline, dosage is 0.8g/d; Positive controls D1 gavage Zhibituo, dosage is 0.1g/d.Another using the healthy rat of the same race 10 of synchronously raising only as blank group, gavage physiological saline, dosage is 0.8g/d.Each treated animal day gavage 1 time, continuous gavage is after 28 days, stop gavage, water 12h is can't help in all animal fasting, weigh, afterbody blood sampling, survey blood fat TC (T-CHOL), TG (triglycerides), HDL-C (HDL-C), LDL-C (LDL-C) content, all average.
1.2 experimental result
Table 2 is on the impact (mmolL of lipid of mice
-1)
| Group | TC | TG | HDL-C | LDL-C |
| Blank group | 3.78±0.15 | 0.62±0.07 | 3.33±0.12 | 0.24±0.06 |
| Negative control group | 9.31±0.47 | 1.13±0.12 | 2.47±0.36 | 6.15±0.17 |
| Positive controls D1 | 5.19±0.16 | 0.75±0.09 | 3.52±0.29 | 1.85±0.23 |
| Experimental group S1 | 4.86±0.73 | 0.69±0.09 | 3.52±0.22 | 0.87±0.13 |
| Experimental group S2 | 4.96±0.55 | 0.77±0.11 | 3.71±0.25 | 0.99±0.14 |
| Experimental group S3 | 5.17±0.08 | 0.83±0.10 | 3.46±0.26 | 1.26±0.21 |
| Experimental group S4 | 5.43±0.03 | 0.86±0.08 | 3.35±0.17 | 1.77±0.24 |
As can be seen from Table 2, compared with negative control group, the TC of experimental group S1-S4, TG, LDL-C all significantly reduce, and HDL-C significantly raises; Illustrate that health food prepared by embodiment 1-4 has good effect for reducing blood fat.Wherein experimental group S1 effect for reducing blood fat is the most remarkable.
The health food of anti-oxidation function prepared by embodiment 1-4 can reduce serum TG, TC content, reduce the effect of peroxidatic reaction of lipid, this is significant to the danger lowering atherosclerotic generation, can play the generation of prevention cardiovascular and cerebrovascular disease to a certain extent.
For verifying the effect of above-mentioned composition, the present invention expands a large amount of special test further, and length limit, and only exemplifies the test example of part most convincingness herein.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1. there is a composition for anti-oxidation function, it is characterized in that, comprise the raw material of following weight portion: grape seed extract 1 ~ 35 part, green-tea extract 1 ~ 50 part, Salvia root P.E 1 ~ 50 part, Astragalus Root P.E 1 ~ 60 part, VE 0.001 ~ 0.01 part.
2. composition according to claim 1, is characterized in that, comprises the raw material of following weight portion: grape seed extract 5 ~ 30 parts, green-tea extract 5 ~ 45 parts, Salvia root P.E 5 ~ 40 parts, Astragalus Root P.E 5 ~ 50 parts, VE 0.002 ~ 0.008 part.
3. composition according to claim 2, it is characterized in that, comprise the raw material of following weight portion: grape seed extract 15 ~ 20 parts, green-tea extract 30 ~ 40 parts, Salvia root P.E 20 ~ 30 parts, Astragalus Root P.E 10 ~ 35 parts, VE 0.003 ~ 0.006 part.
4. composition according to claim 3, is characterized in that, comprises the raw material of following weight portion: grape seed extract 20 parts, green-tea extract 40 parts, Salvia root P.E 20 parts, Astragalus Root P.E 20 parts, VE 0.006 part.
5. the composition according to any one of claim 1-4, is characterized in that, the preparation method of described grape seed extract comprises alcohol extract, concentrated, spraying dry, wherein procyanidin content >=95%; The preparation method of described green-tea extract comprises that water extraction is got, concentrated, spraying dry, wherein polyphenol content >=90%; The preparation method of described Salvia root P.E comprises that water extraction is got, concentrated, spraying dry, wherein content of danshinolic acid B >=10%; The preparation method of described Astragalus Root P.E comprises that water extraction is got, concentrated, spraying dry, wherein Astragaloside content >=0.3%.
6. the composition described in any one of claim 1-5 is preparing the application had in the health food of anti-oxidation function.
7. there is a health food for anti-oxidation function, containing the composition described in any one of claim 1-5.
8. health food according to claim 7, is characterized in that, also containing auxiliary material food allowing use.
9. the health food according to any one of claim 7-8, is characterized in that, described health food formulation is tablet, granule, capsule.
10. right wants the preparation method of health food described in any one of 7-9, it is characterized in that, comprise the following steps: get grape seed extract, green-tea extract, Salvia root P.E, Astragalus Root P.E, VE, interpolation maltodextrin, microcrystalline cellulose mix, and obtain according to a conventional method.
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