CN105263963B - 伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法 - Google Patents
伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法 Download PDFInfo
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- CN105263963B CN105263963B CN201480031344.7A CN201480031344A CN105263963B CN 105263963 B CN105263963 B CN 105263963B CN 201480031344 A CN201480031344 A CN 201480031344A CN 105263963 B CN105263963 B CN 105263963B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
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- Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Mycology (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110182897.4A CN113144195A (zh) | 2013-05-30 | 2014-05-29 | 伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361828730P | 2013-05-30 | 2013-05-30 | |
| US61/828,730 | 2013-05-30 | ||
| US201361889553P | 2013-10-11 | 2013-10-11 | |
| US61/889,553 | 2013-10-11 | ||
| US201361901212P | 2013-11-07 | 2013-11-07 | |
| US61/901,212 | 2013-11-07 | ||
| PCT/US2014/040050 WO2014194111A1 (en) | 2013-05-30 | 2014-05-29 | Methods for treating autosomal dominant hypercholesterolemia associated with pcsk9 gain-of-function mutations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110182897.4A Division CN113144195A (zh) | 2013-05-30 | 2014-05-29 | 伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105263963A CN105263963A (zh) | 2016-01-20 |
| CN105263963B true CN105263963B (zh) | 2021-03-05 |
Family
ID=51205567
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110182897.4A Pending CN113144195A (zh) | 2013-05-30 | 2014-05-29 | 伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法 |
| CN201480031344.7A Active CN105263963B (zh) | 2013-05-30 | 2014-05-29 | 伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110182897.4A Pending CN113144195A (zh) | 2013-05-30 | 2014-05-29 | 伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20140356370A1 (enExample) |
| EP (1) | EP3004172B1 (enExample) |
| JP (1) | JP6423868B2 (enExample) |
| KR (1) | KR20160013046A (enExample) |
| CN (2) | CN113144195A (enExample) |
| AU (1) | AU2014274077B2 (enExample) |
| CA (1) | CA2912101A1 (enExample) |
| EA (1) | EA201592304A1 (enExample) |
| IL (1) | IL242251B (enExample) |
| TW (1) | TWI682780B (enExample) |
| WO (1) | WO2014194111A1 (enExample) |
| ZA (1) | ZA201507798B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| MX366458B (es) | 2011-01-28 | 2019-07-10 | Sanofi Biotechnology | Composiciones farmaceuticas que comprenden anticuerpos humanos frente a pcsk9. |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| MX363642B (es) | 2011-09-16 | 2019-03-28 | Regeneron Pharma | Metodos para reducir los niveles de lipoproteina (a) administrando un inhibidor de proproteina convertasa subtilisina kexina-9 (pcsk9). |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| US10111953B2 (en) | 2013-05-30 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| CN105705521A (zh) | 2013-06-07 | 2016-06-22 | 再生元制药公司 | 通过施用pcsk9抑制剂抑制动脉粥样硬化的方法 |
| ES2914978T3 (es) * | 2013-10-11 | 2022-06-20 | Sanofi Biotechnology | Uso de un inhibidor de PCSK9 para tratar hiperlipidemia |
| MX2016006226A (es) | 2013-11-12 | 2016-09-07 | Sanofi Biotechnology | Regimenes de dosificacion para uso con inhibidores de pcsk9. |
| US9023359B1 (en) | 2014-07-15 | 2015-05-05 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| US9045548B1 (en) | 2014-07-15 | 2015-06-02 | Kymab Limited | Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment |
| US9051378B1 (en) | 2014-07-15 | 2015-06-09 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| US8883157B1 (en) | 2013-12-17 | 2014-11-11 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| US9034332B1 (en) | 2014-07-15 | 2015-05-19 | Kymab Limited | Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment |
| US9914769B2 (en) | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US9139648B1 (en) | 2014-07-15 | 2015-09-22 | Kymab Limited | Precision medicine by targeting human NAV1.9 variants for treatment of pain |
| US9150660B1 (en) | 2014-07-15 | 2015-10-06 | Kymab Limited | Precision Medicine by targeting human NAV1.8 variants for treatment of pain |
| RU2735521C2 (ru) | 2014-07-16 | 2020-11-03 | Санофи Байотекнолоджи | Способы лечения пациентов с гетерозиготной семейной гиперхолестеринемией (hefh) |
| TW201628649A (zh) | 2014-10-09 | 2016-08-16 | 再生元醫藥公司 | 減少醫藥調配物中微可見顆粒之方法 |
| WO2016100615A2 (en) * | 2014-12-18 | 2016-06-23 | The University Of Chicago | Methods and composition for neutralization of influenza |
| EA201890519A1 (ru) | 2015-08-18 | 2018-07-31 | Ридженерон Фармасьютикалз, Инк. | Ингибирующие антитела против pcsk9 для лечения пациентов с гиперлипидемией, подвергающихся аферезу липопротеинов |
| CA3026474A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| IL264631B2 (en) | 2016-08-16 | 2024-05-01 | Regeneron Pharma | A method for quantifying individual antibodies from a mixture |
| EP4071469B1 (en) | 2016-10-25 | 2025-04-09 | Regeneron Pharmaceuticals, Inc. | Methods for chromatography data analysis |
| US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
| US11325945B2 (en) | 2017-04-12 | 2022-05-10 | Cadila Healthcare Limited | Peptide based PCSK9 vaccine |
| US20200223941A1 (en) * | 2017-06-30 | 2020-07-16 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition comprising pcsk-9 antibody and use thereof |
| WO2019060062A1 (en) | 2017-09-19 | 2019-03-28 | Regeneron Pharmaceuticals Inc. | METHODS OF REDUCING PARTICLE FORMATION AND COMPOSITIONS FORMED THEREFROM |
| CN111465848B (zh) | 2017-12-13 | 2023-11-28 | 里珍纳龙药品有限公司 | 管理层析柱床支架的装置和系统及相关方法 |
| TWI853823B (zh) | 2018-07-02 | 2024-09-01 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| BR112021013807A2 (pt) | 2019-01-18 | 2021-11-30 | Astrazeneca Ab | Inibidores de pcsk9 e seus métodos de uso |
| IL323016A (en) * | 2019-11-18 | 2025-10-01 | Ad Pharmaceuticals Co Ltd | Anti-pcsk9 antibody and its use |
| US20230272112A1 (en) | 2019-12-10 | 2023-08-31 | Regeneron Pharmaceuticals, Inc. | Use of a pcsk9 inhibitor to treat homozygous familial hypercholesterolemia |
| IL300439A (en) | 2020-08-25 | 2023-04-01 | Regeneron Pharma | Treatment of sepsis with PCSK9 and LDLR modulators |
| CN116189765B (zh) * | 2023-02-23 | 2023-08-15 | 上海捷易生物科技有限公司 | 一种iPS细胞遗传学风险评估系统及应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010077854A1 (en) * | 2008-12-15 | 2010-07-08 | Regeneron Pharamaceuticals, Inc. | High affinity human antibodies to pcsk9 |
| WO2012146776A1 (en) * | 2011-04-29 | 2012-11-01 | Sanofi | Test systems and methods for identifying and characterising lipid lowering drugs |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| EP1471152A1 (en) * | 2003-04-25 | 2004-10-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Mutations in the human PCSK9 gene associated to hypercholesterolemia |
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| US8357371B2 (en) | 2008-12-15 | 2013-01-22 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to PCSK9 |
| AR079336A1 (es) * | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
| AR087305A1 (es) * | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| MX363642B (es) * | 2011-09-16 | 2019-03-28 | Regeneron Pharma | Metodos para reducir los niveles de lipoproteina (a) administrando un inhibidor de proproteina convertasa subtilisina kexina-9 (pcsk9). |
-
2014
- 2014-05-28 TW TW103118526A patent/TWI682780B/zh not_active IP Right Cessation
- 2014-05-29 EP EP14739600.6A patent/EP3004172B1/en active Active
- 2014-05-29 CA CA2912101A patent/CA2912101A1/en not_active Abandoned
- 2014-05-29 KR KR1020157033966A patent/KR20160013046A/ko not_active Ceased
- 2014-05-29 EA EA201592304A patent/EA201592304A1/ru unknown
- 2014-05-29 CN CN202110182897.4A patent/CN113144195A/zh active Pending
- 2014-05-29 AU AU2014274077A patent/AU2014274077B2/en not_active Ceased
- 2014-05-29 JP JP2016516825A patent/JP6423868B2/ja active Active
- 2014-05-29 WO PCT/US2014/040050 patent/WO2014194111A1/en not_active Ceased
- 2014-05-29 CN CN201480031344.7A patent/CN105263963B/zh active Active
- 2014-05-29 US US14/290,462 patent/US20140356370A1/en not_active Abandoned
-
2015
- 2015-10-19 ZA ZA2015/07798A patent/ZA201507798B/en unknown
- 2015-10-25 IL IL242251A patent/IL242251B/en not_active IP Right Cessation
-
2019
- 2019-03-28 US US16/367,795 patent/US20190330371A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010077854A1 (en) * | 2008-12-15 | 2010-07-08 | Regeneron Pharamaceuticals, Inc. | High affinity human antibodies to pcsk9 |
| WO2012146776A1 (en) * | 2011-04-29 | 2012-11-01 | Sanofi | Test systems and methods for identifying and characterising lipid lowering drugs |
Non-Patent Citations (3)
| Title |
|---|
| PCSK9 inhibition and LDL cholesterol lowering: The biology of an attractive therapeutic target and critical review of the latest clinical trials;Rhainds D等;《Clinical Lipidology》;20121201;第7卷(第6期);第621-640页 * |
| PCSK9在高胆固醇血症中的作用研究进展;崔琴等;《医学综述》;20100831;第16卷(第16期);第2454-2456页 * |
| Rhainds D等.PCSK9 inhibition and LDL cholesterol lowering: The biology of an attractive therapeutic target and critical review of the latest clinical trials.《Clinical Lipidology》.2012,第7卷(第6期),第621-640页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1216896A1 (en) | 2016-12-09 |
| EP3004172B1 (en) | 2019-11-27 |
| TWI682780B (zh) | 2020-01-21 |
| JP2016522211A (ja) | 2016-07-28 |
| CN113144195A (zh) | 2021-07-23 |
| IL242251B (en) | 2020-02-27 |
| CN105263963A (zh) | 2016-01-20 |
| CA2912101A1 (en) | 2014-12-04 |
| KR20160013046A (ko) | 2016-02-03 |
| TW201536315A (zh) | 2015-10-01 |
| WO2014194111A1 (en) | 2014-12-04 |
| US20140356370A1 (en) | 2014-12-04 |
| ZA201507798B (en) | 2017-04-26 |
| AU2014274077B2 (en) | 2019-09-26 |
| EP3004172A1 (en) | 2016-04-13 |
| JP6423868B2 (ja) | 2018-11-14 |
| AU2014274077A1 (en) | 2015-11-19 |
| EA201592304A1 (ru) | 2016-04-29 |
| US20190330371A1 (en) | 2019-10-31 |
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