CN105254741B - 一种生物活性多肽pihnsl及其制备与应用 - Google Patents
一种生物活性多肽pihnsl及其制备与应用 Download PDFInfo
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- CN105254741B CN105254741B CN201510672569.7A CN201510672569A CN105254741B CN 105254741 B CN105254741 B CN 105254741B CN 201510672569 A CN201510672569 A CN 201510672569A CN 105254741 B CN105254741 B CN 105254741B
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- biologically active
- active polypeptide
- pihnsl
- milk
- polypeptide
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- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
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- DOFAQXCYFQKSHT-SRVKXCTJSA-N Val-Pro-Pro Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 DOFAQXCYFQKSHT-SRVKXCTJSA-N 0.000 description 1
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- 108010011559 alanylphenylalanine Proteins 0.000 description 1
- 108010087924 alanylproline Proteins 0.000 description 1
- 108010060802 alpha-casein (90-95) Proteins 0.000 description 1
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- 235000010290 biphenyl Nutrition 0.000 description 1
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- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
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- 230000001079 digestive effect Effects 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
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- 235000013861 fat-free Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
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- 238000004108 freeze drying Methods 0.000 description 1
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- 108010050848 glycylleucine Proteins 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
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- 210000004493 neutrocyte Anatomy 0.000 description 1
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- 239000007800 oxidant agent Substances 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
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- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010106437A1 (en) * | 2009-03-20 | 2010-09-23 | The Governors Of The University Of Alberta | Peptides that inhibit angiotensin converting enzyme and peptides with antioxidant activity purified from ovotransferrin and methods of producing and using the same |
CN103232528A (zh) * | 2012-12-12 | 2013-08-07 | 上海交通大学 | 一种生物活性多肽delq及其制备和应用 |
CN103232526A (zh) * | 2012-12-12 | 2013-08-07 | 上海交通大学 | 一种生物活性多肽lplp及其制备和应用 |
CN104479002A (zh) * | 2014-12-19 | 2015-04-01 | 上海交通大学 | 牛乳β-酪蛋白来源生物活性肽的制备和应用 |
-
2015
- 2015-10-16 CN CN201510672569.7A patent/CN105254741B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010106437A1 (en) * | 2009-03-20 | 2010-09-23 | The Governors Of The University Of Alberta | Peptides that inhibit angiotensin converting enzyme and peptides with antioxidant activity purified from ovotransferrin and methods of producing and using the same |
CN103232528A (zh) * | 2012-12-12 | 2013-08-07 | 上海交通大学 | 一种生物活性多肽delq及其制备和应用 |
CN103232526A (zh) * | 2012-12-12 | 2013-08-07 | 上海交通大学 | 一种生物活性多肽lplp及其制备和应用 |
CN104479002A (zh) * | 2014-12-19 | 2015-04-01 | 上海交通大学 | 牛乳β-酪蛋白来源生物活性肽的制备和应用 |
Non-Patent Citations (1)
Title |
---|
Mutational analysis of immunoglobulin E-binding epitopes of beta-casein and beta-lactoglobulin showed a heterogeneous pattern of critical amino acids between individual patients and pooled sera;Cocco RR等;《Clinical and Experimental Allergy》;PUBMED;20070731;第37卷(第6期);第831-838页 |
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Effective date of registration: 20160823 Address after: Dong Cang Lu Ling Xi Cangnan County of Wenzhou City, Zhejiang province 325899 (panda Industrial Building 1 floor) Applicant after: ZHEJIANG HUITAI LIFE HEALTH TECHNOLOGY Co.,Ltd. Address before: 200240, No. 558, Lane 105, Jinping Road, Shanghai, Minhang District Applicant before: Zhang Shaohui Effective date of registration: 20160823 Address after: 200240, No. 558, Lane 105, Jinping Road, Shanghai, Minhang District Applicant after: Zhang Shaohui Address before: 200240 Dongchuan Road, Shanghai, No. 800, No. Applicant before: Shanghai Jiao Tong University |
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Denomination of invention: A bioactive polypeptide pihnsl and its preparation and Application Effective date of registration: 20210630 Granted publication date: 20190426 Pledgee: Zhejiang Cangnan rural commercial bank Limited by Share Ltd. Pledgor: ZHEJIANG HUITAI LIFE HEALTH TECHNOLOGY Co.,Ltd. Registration number: Y2021330000661 |