CN105246917A - 生产单克隆IgA抗体的方法 - Google Patents

生产单克隆IgA抗体的方法 Download PDF

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Publication number
CN105246917A
CN105246917A CN201480026684.0A CN201480026684A CN105246917A CN 105246917 A CN105246917 A CN 105246917A CN 201480026684 A CN201480026684 A CN 201480026684A CN 105246917 A CN105246917 A CN 105246917A
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CN
China
Prior art keywords
intestinal
iga antibody
monoclonal iga
genus
bacteria
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480026684.0A
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English (en)
Chinese (zh)
Inventor
新蔵礼子
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kansai Bunri Sogo Gakuen
Original Assignee
Kansai Bunri Sogo Gakuen
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Filing date
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Publication of CN105246917A publication Critical patent/CN105246917A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nutrition Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201480026684.0A 2013-03-11 2014-03-10 生产单克隆IgA抗体的方法 Pending CN105246917A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2013-048365 2013-03-11
JP2013048365 2013-03-11
JP2013167120 2013-08-09
JP2013-167120 2013-08-09
PCT/JP2014/056216 WO2014142084A1 (ja) 2013-03-11 2014-03-10 モノクローナルＩｇＡ抗体の製造方法

Publications (1)

Publication Number Publication Date
CN105246917A true CN105246917A (zh) 2016-01-13

Family

ID=51536740

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480026684.0A Pending CN105246917A (zh) 2013-03-11 2014-03-10 生产单克隆IgA抗体的方法

Country Status (5)

Country Link
US (2) US9765151B2 (https=)
EP (1) EP2995679A4 (https=)
JP (2) JP5916946B2 (https=)
CN (1) CN105246917A (https=)
WO (1) WO2014142084A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109504615A (zh) * 2017-09-15 2019-03-22 深圳华大生命科学研究院 单形巨单胞菌（Megamonas funiformis）及其应用
CN110891583A (zh) * 2017-07-18 2020-03-17 学校法人庆应义塾 针对Th1细胞诱导性细菌的抗菌组合物
CN112888448A (zh) * 2018-12-07 2021-06-01 深圳华大生命科学研究院 单形巨单胞菌在预防和/或治疗代谢性疾病中的用途
CN113122507A (zh) * 2021-04-27 2021-07-16 江南大学 一种快速检测铜绿假单胞菌的双抗体夹心elisa方法
US20230202890A1 (en) * 2021-12-28 2023-06-29 Chic-Yi LIN Method for preparing agricultural products from biological sludge containing microbial cells

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9765151B2 (en) * 2013-03-11 2017-09-19 Cured Inc. Method for producing monoclonal IgA antibody
WO2014144292A2 (en) 2013-03-15 2014-09-18 Sanofi Pasteur Biologics , Llc Antibodies against clostridium difficile toxins and methods of using the same
JP7031662B2 (ja) 2017-03-28 2022-03-08 味の素株式会社 腸内環境改善用食品
EP3823727A2 (en) * 2018-07-17 2021-05-26 Humabs Biomed SA Antibodies against campylobacter species
US20230340082A1 (en) * 2020-07-10 2023-10-26 The Wistar Institute Of Anatomy And Biology Dna antibody constructs for use against rotavirus
AU2022269411A1 (en) * 2021-05-04 2023-12-21 Immunorizon Ltd. Anti-nkg2d antibodies and uses thereof
EP4365293A4 (en) * 2021-07-01 2026-03-11 Univ Tokyo ANTIBODIES BINDING TO CLOSTRIDIUM DIFFICILE
CN117580590A (zh) 2021-07-02 2024-02-20 国立大学法人东京大学 用于抑制艰难梭菌的增殖的含有单克隆抗体的组合物
US20250051426A1 (en) 2021-09-30 2025-02-13 Igalphan corporation Composition containing monoclonal antibody
TW202413407A (zh) 2022-08-15 2024-04-01 國立大學法人東京大學 使用絲狀真菌之免疫球蛋白或多聚體免疫球蛋白之製造方法
KR20250158030A (ko) 2023-03-03 2025-11-05 고쿠리츠다이가쿠호우진 도쿄다이가쿠 면역 글로불린
CN121127591A (zh) * 2023-05-12 2025-12-12 国立大学法人东京大学 与艰难梭菌结合的抗体
CN117467016B (zh) * 2023-12-27 2024-03-12 北京索莱宝科技有限公司 人IgA的抗体、抗体组合及其应用
WO2025220732A1 (ja) * 2024-04-17 2025-10-23 国立研究開発法人国立循環器病研究センター 肺高血圧症の予防又は治療薬

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1381567A (zh) * 2001-04-18 2002-11-27 上海博德基因开发有限公司 一种多肽——丝氨酸羟甲基转移酶－10.56和编码这种多肽的多核苷酸

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20140240T4 (hr) * 2005-11-30 2017-02-24 Abbvie Inc. Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba
CN102124027B (zh) * 2008-05-15 2015-01-21 温氏健康有限公司 产生富含分泌型免疫球蛋白的乳组分的方法
US9765151B2 (en) * 2013-03-11 2017-09-19 Cured Inc. Method for producing monoclonal IgA antibody

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1381567A (zh) * 2001-04-18 2002-11-27 上海博德基因开发有限公司 一种多肽——丝氨酸羟甲基转移酶－10.56和编码这种多肽的多核苷酸

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
READ M等: "Dynamic subcellular localization of isoforms of the folate pathway enzyme serine hydroxymethyltransferase(SHMT)through the erythrocytic cycle of plasmodium falciparum", 《MALARIA JOURNAL》 *
TURNER SR等: "Identification and localization of multiple forms of serine hydroxymethyltransferase in pea (Pisum sativum) and characterization of a cDNA encoding a mitochondrial isoform", 《J BIOL CHEM》 *
新蔵礼子: "腸内フローラ制御に有効な腸管IgA抗体の分離", 《ヤクルト バイオサイエンス研究財団年報》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110891583A (zh) * 2017-07-18 2020-03-17 学校法人庆应义塾 针对Th1细胞诱导性细菌的抗菌组合物
CN110891583B (zh) * 2017-07-18 2023-06-06 学校法人庆应义塾 针对Th1细胞诱导性细菌的抗菌组合物
CN109504615A (zh) * 2017-09-15 2019-03-22 深圳华大生命科学研究院 单形巨单胞菌（Megamonas funiformis）及其应用
CN112888448A (zh) * 2018-12-07 2021-06-01 深圳华大生命科学研究院 单形巨单胞菌在预防和/或治疗代谢性疾病中的用途
CN113122507A (zh) * 2021-04-27 2021-07-16 江南大学 一种快速检测铜绿假单胞菌的双抗体夹心elisa方法
US20230202890A1 (en) * 2021-12-28 2023-06-29 Chic-Yi LIN Method for preparing agricultural products from biological sludge containing microbial cells

Also Published As

Publication number Publication date
WO2014142084A1 (ja) 2014-09-18
US9765151B2 (en) 2017-09-19
US20160039944A1 (en) 2016-02-11
US20180009906A1 (en) 2018-01-11
JP2016183153A (ja) 2016-10-20
EP2995679A4 (en) 2016-12-14
JPWO2014142084A1 (ja) 2017-02-16
EP2995679A1 (en) 2016-03-16
JP5916946B2 (ja) 2016-05-11

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Effective date of registration: 20170316

Address after: Kanagawa, Japan

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Applicant before: KANSAI BUNRI SOGO GAKUEN

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Application publication date: 20160113

WD01 Invention patent application deemed withdrawn after publication