CN112888448A - 单形巨单胞菌在预防和/或治疗代谢性疾病中的用途 - Google Patents

单形巨单胞菌在预防和/或治疗代谢性疾病中的用途 Download PDF

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CN112888448A
CN112888448A CN201880098835.1A CN201880098835A CN112888448A CN 112888448 A CN112888448 A CN 112888448A CN 201880098835 A CN201880098835 A CN 201880098835A CN 112888448 A CN112888448 A CN 112888448A
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megamonas
funiformis
mammal
metabolic disease
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CN112888448B (zh
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戴莹
邹远强
肖亮
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Wuhan Huada Institute Of Life Sciences
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Abstract

提供一种单形巨单胞菌(Megamonas funiformis)在预防和/或治疗代谢性疾病中的用途,单形巨单胞菌具有预防和/或治疗代谢性疾病(如肥胖、糖尿病、动脉粥样硬化相关疾病、心血管疾病、高尿酸血症)的作用。

Description

PCT国内申请,说明书已公开。

Claims (36)

  1. PCT国内申请,权利要求书已公开。
CN201880098835.1A 2018-12-07 2018-12-07 单形巨单胞菌在预防和/或治疗代谢性疾病中的用途 Active CN112888448B (zh)

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PCT/CN2018/119909 WO2020113579A1 (zh) 2018-12-07 2018-12-07 单形巨单胞菌在预防和/或治疗代谢性疾病中的用途

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109504615A (zh) * 2017-09-15 2019-03-22 深圳华大生命科学研究院 单形巨单胞菌(Megamonas funiformis)及其应用
CN115449490A (zh) * 2021-08-19 2022-12-09 中国农业大学 一种单形巨单胞菌及其应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112867500B (zh) * 2018-12-07 2023-08-01 深圳华大生命科学研究院 人粪厌氧棒形菌在预防和/或治疗代谢性疾病中的用途

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040170617A1 (en) * 2000-06-05 2004-09-02 Finegold Sydney M. Method of treating diseases associated with abnormal gastrointestinal flora
JP2010163391A (ja) * 2009-01-16 2010-07-29 Shionogi & Co Ltd 糖尿病又は高脂血症治療用医薬組成物
US20120107291A1 (en) * 2009-06-19 2012-05-03 Danisco A/S Bifidobacteria for treating diabetes and related conditions
CN104546938A (zh) * 2014-09-30 2015-04-29 深圳华大基因科技有限公司 极巨巨单胞菌在治疗或预防类风湿性关节炎或其相关疾病中的应用
CN105246917A (zh) * 2013-03-11 2016-01-13 学校法人关西文理综合学园 生产单克隆IgA抗体的方法
WO2016049879A1 (zh) * 2014-09-30 2016-04-07 上海交通大学医学院附属瑞金医院 拟杆菌在治疗或预防肥胖相关疾病中的用途
JP2017001987A (ja) * 2015-06-11 2017-01-05 学校法人関西文理総合学園 ポリペプチド
CN106479906A (zh) * 2015-08-27 2017-03-08 深圳华大基因研究院 肠道细菌丁酸杆菌(Butyribacter intestini)及其应用
CN106795481A (zh) * 2014-09-30 2017-05-31 深圳华大基因科技有限公司 用于肥胖症相关疾病的生物标记物
CN107847531A (zh) * 2015-05-21 2018-03-27 耶达研究及发展有限公司 用于促进健康的细菌群
US20180117102A1 (en) * 2016-11-03 2018-05-03 Cell Biotech Co., Ltd. Composition for preventing or treating obesity or lipid-related metabolic disease
WO2018187272A1 (en) * 2017-04-03 2018-10-11 Gusto Global, Llc Rational design of microbial-based biotherapeutics
CN109504615A (zh) * 2017-09-15 2019-03-22 深圳华大生命科学研究院 单形巨单胞菌(Megamonas funiformis)及其应用

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040170617A1 (en) * 2000-06-05 2004-09-02 Finegold Sydney M. Method of treating diseases associated with abnormal gastrointestinal flora
JP2010163391A (ja) * 2009-01-16 2010-07-29 Shionogi & Co Ltd 糖尿病又は高脂血症治療用医薬組成物
US20120107291A1 (en) * 2009-06-19 2012-05-03 Danisco A/S Bifidobacteria for treating diabetes and related conditions
CN105246917A (zh) * 2013-03-11 2016-01-13 学校法人关西文理综合学园 生产单克隆IgA抗体的方法
CN106795481A (zh) * 2014-09-30 2017-05-31 深圳华大基因科技有限公司 用于肥胖症相关疾病的生物标记物
CN104546938A (zh) * 2014-09-30 2015-04-29 深圳华大基因科技有限公司 极巨巨单胞菌在治疗或预防类风湿性关节炎或其相关疾病中的应用
WO2016049879A1 (zh) * 2014-09-30 2016-04-07 上海交通大学医学院附属瑞金医院 拟杆菌在治疗或预防肥胖相关疾病中的用途
CN107847531A (zh) * 2015-05-21 2018-03-27 耶达研究及发展有限公司 用于促进健康的细菌群
US20180140648A1 (en) * 2015-05-21 2018-05-24 Yeda Research And Development Co. Ltd. Bacterial populations for promoting health
JP2017001987A (ja) * 2015-06-11 2017-01-05 学校法人関西文理総合学園 ポリペプチド
CN106479906A (zh) * 2015-08-27 2017-03-08 深圳华大基因研究院 肠道细菌丁酸杆菌(Butyribacter intestini)及其应用
US20180117102A1 (en) * 2016-11-03 2018-05-03 Cell Biotech Co., Ltd. Composition for preventing or treating obesity or lipid-related metabolic disease
WO2018187272A1 (en) * 2017-04-03 2018-10-11 Gusto Global, Llc Rational design of microbial-based biotherapeutics
CN109504615A (zh) * 2017-09-15 2019-03-22 深圳华大生命科学研究院 单形巨单胞菌(Megamonas funiformis)及其应用

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
任慧妍;蒋建霞;: "肠道微生态与非消化系统疾病的研究进展" *
徐海燕;马慧敏;王彦杰;赵飞燕;刘亚华;海棠;张和平;孙志宏;: "肥胖人群肠道细菌多样性研究" *
朱翠玲;高仁元;李豪;秦环龙;曲伸: "单纯性肥胖及肥胖伴黑棘皮病患者肠道微生态的结构差异" *
李奇威;王业胜;周林;朱爽;: "代谢性疾病与肠道菌群关系的研究进展" *
王春梅;严寿南;钱武安;沈国强;: "高尿酸血症与代谢性及心血管疾病的相关性分析" *
王柯;万群;葛林;于晓红;李鸣;郭云;胡敏;马新颖;崔文静;何方;: "成都地区中老年人肠道菌群与其血糖、血脂代谢关系的初探" *
苗蕾;张弘炎;姚华;孙玉萍;木斯林・苏克尔拜;史惠;: "高尿酸血症与代谢性疾病的民族异质性分析" *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109504615A (zh) * 2017-09-15 2019-03-22 深圳华大生命科学研究院 单形巨单胞菌(Megamonas funiformis)及其应用
CN115449490A (zh) * 2021-08-19 2022-12-09 中国农业大学 一种单形巨单胞菌及其应用
CN115449490B (zh) * 2021-08-19 2024-01-12 中国农业大学 一种单形巨单胞菌及其应用

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WO2020113579A1 (zh) 2020-06-11
CN112888448B (zh) 2023-07-25

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