CN105232350B - Water surface film and preparation method thereof - Google Patents
Water surface film and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention provides a kind of water surface film and preparation method thereof, belong to facial mask field, it is mainly made up of hydrogel matrix, myricetin, myricetrin and dihydromyricetin, and the mole ratio between the myricetin, myricetrin and dihydromyricetin is 0.8~1.2：0.8~1.2：0.8~1.2.The preparation method of facial mask includes grinding, is stirred and the step such as is coated with.Water surface film provided by the invention and preparation method thereof is nontoxic and will not be to skin generation side effect using the active ingredient of the myricetin, myricetrin, dihydromyricetin that are extracted from natural plants as facial mask.
Description
Technical field
The present invention relates to facial mask field, in particular to a kind of water surface film and preparation method thereof.
Background technology
The principle of facial mask skin care is：Face is applied using a thick layer of elite, contact of the barrier skin with air, reduces skin water
The evaporation divided, increase the humidity of cuticula, cutin-softening.Skin temperature rise is advantageous to nutritional ingredient so as to expand pore
Smoothly absorbed, after skin temperature rises blood circulation accelerate, the nutrient of infiltration skin is broadly spread iuntercellular is deeper
Open, it is quick to supplement the nutrients.Those moisture that can not be evaporated of skin surface can then be deposited in epidermis, full of the moisture of epidermis
Come, skin seem will smoother it is tight, microgroove can also become light, while fairness, brightness are obviously improved.
Nowadays the facial mask species of all kinds of effects of in the market is various, and major skin care item manufacturer also improves oneself trying one's best
Skin care item the effect of, facial mask as one kind in numerous skin care item species, its act on also gradually developed by people it is perfect, still
Existing facial mask is mostly using some cheap chemical substances as raw material, although having the effect of certain, after long-term use
In the presence of certain side effect.
The content of the invention
The invention provides a kind of water surface film and preparation method thereof, it is intended to improves above-mentioned technical problem.
What the present invention was realized in：
A kind of water surface film, is mainly made up of hydrogel matrix, azone, myricetin, myricetrin and dihydromyricetin, the poplar
Mole ratio between syphilis, myricetrin and dihydromyricetin is 0.8~1.2：0.8~1.2：0.8~1.2, the red bayberry
Element, the concentration of myricetrin and dihydromyricetin in the hydrogel matrix are 1 μM~3 μM.
Hydrogel matrix forms the basic ingredient of facial mask, and myricetin, myricetrin and dihydromyricetin are straight from red bayberry
The natural materials of extraction are connect, are had no toxic side effect.During making, myricetin, myricetrin and dihydromyricetin are in proportion uniformly and water
Gel-type vehicle is mixed and is coated on non-woven fabrics.Obtained water surface film, the outward appearance of facial mask, matrix residual, skin tracing ability and
The effect of uniformity is higher, chemiluminescence between each composition, can dramatically increase H in skin during use2O2With SOD enzyme activity
Power, the cleaning, skin care effect to skin are high, and will not produce toxic side effect.
SOD has good affinity interaction to the collagen in blood vessel and hard elastics albumen, enhances cells of vascular wall
Metabolic function, play a part of cleaning skin, recover skin-tightening smoothing wrinkle.H2O2There is whitening function to skin, play desalination
It the effect of pigment, can be fully skin moisturizing simultaneously because having large quantity of moisture in water surface film, make skin more water profit light
Pool.
In use, pore is expanded, myricetin, myricetrin and dihydromyricetin warp because of the temperature rise of skin surface
Pore is absorbed, and because these compositions extract from pure plant, will not produce the pair to skin and human body
Effect.
And three kinds of active ingredient object light toxic actions, by allocating between myricetin, myricetrin and dihydromyricetin
Ratio, the crowd for being adapted to different skin quality use.
Further, percentage, the hydrogel matrix contain water 60%~68%, EDTA-2Na0~
0.1%th, azone 0~1.2%, kaolin 0~1%, thickener 0.6%~3.9%, Sodium Polyacrylate 4%~7%, Dihydroxyaluminium Aminoacetate
0.1%~0.25%, organic acid 0.1%~0.3% and NMF 9.6%~23%.
Thickener has certain plasticity, and such facial mask when in use, can more closely be bonded with facial skin, prevent
Facial mask slips in the presence of self gravitation from face.Organic acid can adjust the model that the pH value of facial mask composition uses to suitable people
Enclose, and NMF then can moisten facial mask more water, and pin the natural nutrient component in facial mask.
These components make facial mask lustrous surface, are not in micelle, while completed when facial mask uses by reasonably matching
Afterwards, matrix residual will not be formed on facial skin.
Further, the thickener includes sodium carboxymethylcellulose and polyvinylpyrrolidone, the carboxymethyl cellulose
The percentage by weight of plain sodium is 1.3%~1.7%, and the percentage by weight of polyvinylpyrrolidone is 0.5%~0.7%.
Sodium carboxymethylcellulose (CMC-Na), it is the cellulose derivative that glucose polymerization degree is 100~2000, it is odorless,
It is tasteless and there is hygroscopicity.It can guarantee that moisture is not lost in, while strengthen the plasticity of facial mask.Polyvinylpyrrolidone equally has
Hydrophily and good physiology intermiscibility, good fluidity when being dissolved in water, use it as thickener, the caking property of facial mask and moisture absorption
Property all greatly enhances.
Preferably, the percentage by weight of the sodium carboxymethylcellulose is 1.5%, the weight percent of polyvinylpyrrolidone
Than for 0.6%.
Further the NMF includes glycerine and polyethylene glycol (PEG), and the percentage by weight of the glycerine is 7.2%
~18%, the percentage by weight of the polyethylene glycol is 2.4%~5%.
Glycerine and polyethylene glycol are respectively provided with good water solubility, and nontoxic nonirritant, are suitable for use as the NMF of facial mask.
Other such as propane diols, sorbierite can also be used as NMF.
Further, the percentage by weight of the Sodium Polyacrylate is 5.2%, and the percentage by weight of Dihydroxyaluminium Aminoacetate is
0.15%, the percentage by weight of organic acid is 0.1%, and the weight ratio of glycerine and polyethylene glycol is 22:2.
Preferably, the percentage by weight of Sodium Polyacrylate is 4%~5.2%, and the percentage by weight of Dihydroxyaluminium Aminoacetate is 0.15%,
The percentage by weight of organic acid is 0.1% or 0.3%, and the percentage by weight of NMF is 23%~24%.
Preferably, the organic acid is tartaric acid.
Further, the mole ratio between the myricetin, myricetrin and dihydromyricetin is 0.9~1.1：0.9
~1.1：0.9~1.1.
When the mole Ratio control between myricetin, myricetrin and dihydromyricetin within this range when, in water surface film
Nutritional ingredient it is more balanced, be easy to be absorbed by human body skin.
It is highly preferred that the mole ratio between the myricetin, myricetrin and dihydromyricetin is 1：1：1.This ratio
Under value, the proportioning of myricetin, myricetrin and dihydromyricetin is most appropriate.
The preparation method of water surface film, comprises the following steps：
(1) by Sodium Polyacrylate, thickener, EDTA-2Na and Dihydroxyaluminium Aminoacetate mixed grinding, by the powder after grinding and moisturizing
Agent is stirred into oil phase mixed liquor；
(2) organic acid is soluble in water, it is 2~3 to control pH, adds kaolin and polyvinylpyrrolidone and mixes and stirs
Mix, pour into afterwards in the oil phase mixed liquor and be stirred together for that bare substrate is made, the pH of the bare substrate is 6~7；
(3) myricetin, myricetrin and dihydromyricetin are mixed with azone and adds the bare substrate mixing；Even spread
On non-woven fabrics；
(4) room temperature places at least 24h, sticks anti-mucous membrane and preserves.
By controlling pH environment when making, the facial mask composition for making to produce is in suitable pH scopes, can be effective
Pinning nutritional ingredient will not be denatured these nutritional ingredients again simultaneously.Azone can effectively help face as a kind of bleeding agent
Active ingredient in film is penetrated among skin, beneficial to the absorption of active ingredient.
It should be noted that above-mentioned steps numbering does not represent production order.
Further, in step (2), when organic acid is dissolved in water, it is 2.2~2.5 to control pH.
Further, in step (2), when organic acid is dissolved in water, it is 2.38 to control pH.
The beneficial effects of the invention are as follows：Water surface film provided by the invention and preparation method thereof is used and extracted from natural plants
Active ingredient as facial mask of myricetin, myricetrin, dihydromyricetin, it is nontoxic and side effect will not be produced to skin.
Brief description of the drawings
Fig. 1 is curve map of three kinds of active components to the CDCC of 3T3-L1 cells；
Fig. 2 is the curve map of influence of three kinds of active components under+UVA to cell survival rate；
Fig. 3 is the curve map of influence of three kinds of active components under-UVA to cell survival rate.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, based on the embodiment in the present invention, sheet
The every other embodiment that field those of ordinary skill is obtained under the premise of creative work is not made, belongs to the present invention
The scope of protection.
Test example 1
In above-described embodiment, myricetin, myricetrin and dihydromyricetin extract from red bayberry, and inventor is to myricetin, poplar
The toxicity of antimellin and dihydromyricetin, security and oxidation resistance have carried out experimental verification.
With A=myricetins, B=myricetrins, C=dihydromyricetins are tested.
First, take the logarithm phase 3T3-L1 cell, be inoculated in by the μ L of cell number 1 × 104/100 in 96 orifice plates, after cultivating 24h,
The drug containing nutrient solution processing of 200 μ L/ holes Chrysins containing various concentrations is added, while control group and blank group are set, every group 8 multiple
Hole.After cultivating 48h, MTT working solutions (5g/L) 30 μ L are added per hole, continues to cultivate 4h, discards nutrient solution in hole, add DMSO
150 μ L, micro oscillator concussion 10min, after thing to be precipitated is completely dissolved, absorbance is read with ELIASA at wavelength 570nm
Value, cell survival rate is calculated by formula.Cell survival rate is with " (administration group OD values-blank group OD values)/(control group OD values-blank
Group OD values) × 100% " calculating.Obtain the CDCC relation of three kinds of active components as shown in Figure 1 to 3T3-L1 cells
Figure, from figure result, three kinds of active ingredients do not have CDCC.
Secondly, the 3T3 dimethyl diaminophenazine chloride fibroblasts light poison for active component being carried out with 3T3-L1 cell models substitutes experiment, comments
The phototoxicity of 3 kinds of active components of valency.Method is as follows, and experiment is divided into+UVA groups and-UVA groups, and every group is respectively provided with blank control, solvent
Control and positive control.Dimethyl diaminophenazine chloride stoste (0.4% dimethyl diaminophenazine chloride water dyestuff, room temperature condition under can preserve 2 months) is prepared,
1mL dimethyl diaminophenazine chloride stostes are added in 79mLDMEM nutrient solutions, as using liquid.The final concentration of 50 μ l/mol of dimethyl diaminophenazine chloride.Prepare neutral
Distilled water, ethanol, acetic acid (are pressed 49 by red desorption solution:50:1 ratio is prepared, matching while using, and storage is no more than 1 hour).
Prepare two 96 orifice plates (+UVA and-UVA) and the 3T3-L1 that 100 μ L density are 1 × 105 cell/m L is added per hole
Cell suspension (i.e. 1 × 104 cells/well).Cultivate cell and extremely form semi-fusion cell monolayer in 24 hours.Nutrient solution is removed, with 150
μ LPBS are rinsed twice.The buffer solution of 100 μ l tested materials containing various concentrations is added, continues in incubator and cultivates cell 1 hour.
One of plate is subjected to 365nm, 254nmUV exposure at room temperature, it is thin through the irradiation of 96 orifice plate lids with 0.1mW/cm2 luminous intensities
Born of the same parents 50min, while control board is placed in 50min in magazine.Supernatant is removed, is rinsed twice with 150 μ l PBS.Add 100 μ l
Nutrient solution overnight incubation.Cell is rinsed with 150 μ l pre-temperatures PBS twice.The nutrient solution that 100 μ l contain 50 μ g/mL dimethyl diaminophenazine chlorides is added, after
Continuous culture cell 3 hours.Dimethyl diaminophenazine chloride nutrient solution is removed, cell is rinsed once with 150 μ l PBS.Add the desorption of 150 μ l dimethyl diaminophenazine chlorides
Attached solution.Micro shaker vibrates 10min, to dimethyl diaminophenazine chloride from being extracted into the cell, and forms homogeneous solution.Use ELIASA
Determine optical density of the solution at 540nm wavelength.Cell survival rate is calculated by following equation：(administration group OD values-blank group OD
Value)/(control group OD values-blank group OD values).Have under light conditions, cell survival rate is more than control group, illustrates active component pair
Damage has protective effect caused by ultraviolet.As a result Fig. 2 is seen.
Fig. 2 and Fig. 3 results show, 3 compositions are without phototoxic action, and result no difference of science of statistics.Three kinds are had
Effect composition mixing is tested, and experimental result, which equally shows as the damage to caused by ultraviolet, protective effect.
Test example 2
The external influence for investigating finished product facial mask to skin epidermal cells hydrogen peroxide and total SOD vigor.
The influence of hydrogen peroxide vigor：(respectively using single three kinds of compositions and by 1:1:The mixing sample ingredient of 1 proportioning
Tested)
I. the preparation of sample measure：After 24h is administered, cell is collected, cell suspension is made, 0.4% trypan blue counts, and ensures
Living cell rate >=95%, 1000g centrifuges 3min, abandons supernatant, adds 200 μ l hydrogen peroxide detection lysate, fully homogenate is with broken
Schistocyte, 4 DEG C of 12000g centrifuge 5min, take supernatant.
II. the making of peroxide standard curve：1mM Hydrogen peroxide standard product are diluted to 0.1,0.3,1,3,10 μM
5 concentration, determine absorbance at wavelength 560nm, and its polynomial equation is：Y=-0.0002x2+0.0260x+0.0573 (R2
=0.9993).
III. the measure of sample concentration of hydrogen peroxide：50 μ l samples are added in each detection hole, add 100 μ l peroxidating
Hydrogen detection reagent, micro oscillator survey A560 immediately after shaking 30min, and it is dense to calculate hydrogen peroxide in sample according to standard curve
Degree, the results are shown in Table 1.
Influence of the SOD red bayberries active component of table 1 to concentration of hydrogen peroxide
Note：Compared with normal group, * p ＜ 0.01, #p ＜ 0.05
As a result show, after three kinds of ingredient administrations, intracellular H2O2Concentration raises.
Cell SOD Activity determination：(carried out respectively using single three kinds of compositions and vitamin E (VE) positive control real
Test), mixed when by three kinds of compositions, and tested in the case where dosage is consistent, intracellular H2O2Concentration can reach
0.91 ± 0.001* μm of ol/L, far above normal value and only add level during single composition.
Method is as follows：After 24h is administered, cell is collected, cell suspension is made, 0.4% trypan blue counts, and ensures living cells
Rate >=95%, 1000g centrifuges 3min, abandons supernatant, adds 200 μ l cell pyrolysis liquids, and fully homogenate is to rupture cell, 4 DEG C
12000g centrifuges 5min, takes supernatant.
3,37 DEG C of sample well, blank control 1, blank control 2, blank control incubation 30min are set with green skies kit
Absorbance is determined at wavelength 450nm afterwards.Calculate inhibiting rate.Inhibiting rate percentage=((A blank control 1-A blank controls 2)-
(A sample-A blank controls 3))/(A blank control 1-A blank controls 2) * 100%；Testing sample SOD enzyme activity units=suppression
Percentage/(1- suppresses percentage) units.It the results are shown in Table 2.
Influence of the SOD red bayberries active component of table 2 to SOD enzyme activities
Note：Compared with normal group, #p ＜ 0.05
It was found from above-mentioned experiment, the facial mask provided in above-described embodiment can dramatically increase H in skin2O2With SOD enzyme activity
Power, effect are better than the vitamin E of positive controls, and the cleaning, skin care effect to skin are high, and will not produce toxic side effect.When
When three kinds of compositions mixing are tested, intracellular SOD enzyme activities (U/mg) can reach 120.53U/mg, far above normal value
Only add level during single composition.
Three kinds of active ingredients are mixed and tested, experimental result does not show toxic side effect equally.
Test example 3
Orthogonal experiment is carried out to the composition proportion of hydrogel matrix：
It is 100g to draft lotion quality, institute aqueous 60-68g, EDTA-2NA 0.1g, kaolin 1g, thickener (carboxymethyl
Sodium cellulosate 1.5g, PVP0.6g), from gel skeleton (Sodium Polyacrylate AH-105X), crosslinking agent (Dihydroxyaluminium Aminoacetate), organic acid
(tartaric acid), NMF (glycerine, PEG) are used as investigation factor, and orthogonal test designs table is formulated using 3 factor 4 is horizontal.
The orthogonal test designs table of table 3
Tested by L934 orthogonal arrages.
Experimental method and criteria of quality evaluation are as follows：
The criteria of quality evaluation of table 4
Meanwhile the initial adhesion force of facial mask is tested, method of testing is：Test sample is placed in hang plate (15 ° of inclination angle)
Center, upwardly, inclined-plane top 10cm and bottom 15cm are covered cream with mylar thick 0.025mm, and centre reserves 5cm, are remembered
The steel ball number that test product of taking down a confession or testimony during an interrogation can be clung.And using lotion upper limb as 0 point, rolling distance of the measurement steel ball on lotion, parallel 3
It is secondary, record experimental data.Using actually measured maximum steel ball minimum range as 10 points, remaining score calculates just in comparison
Viscous force score.
Experimental result such as following table：
The orthogonal experiments analytical table of table 5
| A | B | C | D | ||
| Factor | AH-105X | Dihydroxyaluminium Aminoacetate | Tartaric acid | Glycerine：PEG | Experimental result |
| Experiment 1 | 1 | 1 | 1 | 1 | 33 |
| Experiment 2 | 1 | 2 | 2 | 2 | 35 |
| Experiment 3 | 1 | 3 | 3 | 3 | 35 |
| Experiment 4 | 2 | 1 | 2 | 3 | 40 |
| Experiment 5 | 2 | 2 | 3 | 1 | 47 |
| Experiment 6 | 2 | 3 | 1 | 2 | 42 |
| Experiment 7 | 3 | 1 | 3 | 2 | 46 |
| Experiment 8 | 3 | 2 | 1 | 3 | 47 |
| Experiment 9 | 3 | 3 | 2 | 1 | 35 |
| K1 | 34.333 | 39.667 | 40.667 | 38.333 | |
| K2 | 43.000 | 43.000 | 36.667 | 41.000 | |
| K3 | 42.667 | 37.333 | 42.667 | 40.667 | |
| R | 8.667 | 5.667 | 6.000 | 2.667 |
To the above results carry out variance analysis, while because under D factor items sum of squares of deviations it is smaller, be included in error term,
Carry out F inspections.Understand that A factors have a significant effect to gel ointment by result, be principal element.D factor sums of squares of deviations are smaller
And error term is classified, gel ointment is influenceed smaller.Consider each factor, optimal prescription proportioning is A2B2C3D2.
It can also be analyzed by table 5, be 4%~5.2% in the percentage by weight of Sodium Polyacrylate, the weight percent of Dihydroxyaluminium Aminoacetate
Than for 0.15%, the percentage by weight of organic acid is 0.1% or 0.3%, glycerine with and the weight ratio of polyethylene glycol be 22:2
When, K values are all higher than 40, show the effect of under the formula rate outward appearance of facial mask, matrix residual, skin tracing ability and uniformity
Fruit is higher.
Embodiment 1
A kind of water surface film is present embodiments provided, mainly by hydrogel matrix, myricetin, myricetrin and dihydromyricetin system
Into the mole ratio between the myricetin, myricetrin and dihydromyricetin is 0.8：0.9：0.8, wherein myricetin exists
Concentration in 100g hydrogel matrixes is 0.1 μM.
Wherein, hydrogel matrix is mainly by water, EDTA-2Na, kaolin, thickener, Sodium Polyacrylate, Dihydroxyaluminium Aminoacetate, organic
Acid and NMF are made, wherein per in 100g hydrogel matrixes, azone 1.2g, EDTA-2Na 0.1g, kaolin 1g, increase
Thick dose is 1.8g, and Sodium Polyacrylate 7g, Dihydroxyaluminium Aminoacetate 0.1g, tartaric acid 0.1g, NMF 23g, surplus is water.
Specifically, thickener is sodium carboxymethylcellulose and polyvinylpyrrolidone (PVP), wherein carboxymethyl cellulose
Sodium is 1.3g, polyvinylpyrrolidone 0.5g.
Specifically, NMF is glycerine and polyethylene glycol (PEG), and wherein glycerine is 18g, polyethylene glycol 5g.At this
In embodiment, organic acid is tartaric acid.
The water surface film that the present embodiment provides so is made：
(1) Sodium Polyacrylate, thickener, EDTA-2Na and Dihydroxyaluminium Aminoacetate are put into mixed grinding in mortar, after grinding
Powder and NMF are under stirring at low speed uniformly into oil phase mixed liquor.
(2) tartaric acid acid is soluble in water, control ph is 2~3, adds kaolin and polyvinylpyrrolidone and mixes
Stirring, pour into afterwards in oil phase mixed liquor and be stirred together for that bare substrate is made, the pH value of obtained bare substrate is 6~7.
(3) myricetin, myricetrin and dihydromyricetin are pressed 0.8:0.9:0.8 ratio mixes with azone, adds blank
Mixed, and be uniformly coated on 5 non-woven fabrics in matrix.
(4) room temperature places 24h, sticks anti-stick lid lining form and preserves.
Through examining, the effect of water surface film outward appearance, matrix residual, skin tracing ability and uniformity obtained by the present embodiment is equal
It is higher.
Embodiment 2
A kind of water surface film is present embodiments provided, mainly by hydrogel matrix, myricetin, myricetrin and dihydromyricetin system
Into the mole ratio between the myricetin, myricetrin and dihydromyricetin is 1：0.9：0.8, wherein myricetin is in 100g
Concentration in hydrogel matrix is 0.2 μM.
Wherein, hydrogel matrix is mainly by water, EDTA-2Na, kaolin, thickener, Sodium Polyacrylate, Dihydroxyaluminium Aminoacetate, organic
Acid and NMF are made, wherein per in 100g hydrogel matrixes, azone 1.2g, EDTA-2Na 0.1g, kaolin 1g, increase
Thick dose is 1.8g, and Sodium Polyacrylate 7g, Dihydroxyaluminium Aminoacetate 0.1g, tartaric acid 0.1g, NMF 23g, surplus is water.
Specifically, thickener is sodium carboxymethylcellulose and polyvinylpyrrolidone (PVP), wherein carboxymethyl cellulose
Sodium is 1.3g, polyvinylpyrrolidone 0.5g.
Specifically, NMF is glycerine and polyethylene glycol (PEG), and the wherein weight ratio of glycerine and polyethylene glycol is 28:
3, in addition in the present embodiment, organic acid is tartaric acid.
The water surface film that the present embodiment provides so is made：
(1) Sodium Polyacrylate, thickener, EDTA-2Na and Dihydroxyaluminium Aminoacetate are put into mixed grinding in mortar, after grinding
Powder and NMF are under stirring at low speed uniformly into oil phase mixed liquor.
(2) tartaric acid acid is soluble in water, control ph is 2~3, adds kaolin and polyvinylpyrrolidone and mixes
Stirring, pour into afterwards in oil phase mixed liquor and be stirred together for that bare substrate is made, the pH value of obtained bare substrate is 6~7.
(3) myricetin, myricetrin and dihydromyricetin are pressed 1:0.9:0.8 ratio mixes with azone, adds blank base
Mixed, and be uniformly coated on 5 non-woven fabrics in matter.
(4) room temperature places 24h, sticks anti-stick lid lining form and preserves.
Through examining, the effect of water surface film outward appearance, matrix residual, skin tracing ability and uniformity obtained by the present embodiment is equal
It is higher.
Embodiment 3
A kind of water surface film is present embodiments provided, mainly by hydrogel matrix, myricetin, myricetrin and dihydromyricetin system
Into the mole ratio between the myricetin, myricetrin and dihydromyricetin is 1：1：1, wherein myricetin is in 100g water-settings
Concentration in gel matrix is 0.15 μM.
Wherein, hydrogel matrix is mainly by water, EDTA-2Na, kaolin, thickener, Sodium Polyacrylate, Dihydroxyaluminium Aminoacetate, organic
Acid and NMF are made, and wherein in hydrogel matrix, azone 1.2g, EDTA-2Na 0.1g, kaolin 1g, thickener is
3.9g, Sodium Polyacrylate 4g, Dihydroxyaluminium Aminoacetate 0.05g, tartaric acid 0.1g, NMF 9.6g, surplus are water.
Specifically, thickener is sodium carboxymethylcellulose and polyvinylpyrrolidone (PVP), wherein carboxymethyl cellulose
Sodium is 1.3g, polyvinylpyrrolidone 0.5g.
Specifically, NMF is glycerine and polyethylene glycol (PEG), and the wherein weight ratio of glycerine and polyethylene glycol is 22:
2, in addition in the present embodiment, organic acid is tartaric acid.
The water surface film that the present embodiment provides so is made：
(1) Sodium Polyacrylate, thickener, EDTA-2Na and Dihydroxyaluminium Aminoacetate are put into mixed grinding in mortar, after grinding
Powder and NMF are under stirring at low speed uniformly into oil phase mixed liquor.
(2) it is tartaric acid acid is soluble in water, control ph 2.38, add kaolin and polyvinylpyrrolidone and mix
Stirring, pour into afterwards in oil phase mixed liquor and be stirred together for that bare substrate is made, the pH value of obtained bare substrate is 6~7.
(3) myricetin, myricetrin and dihydromyricetin are pressed 1：1：1 ratio mixes with azone, adds in bare substrate
Mixed, and be uniformly coated on 5 non-woven fabrics.
(4) room temperature places 24h, sticks anti-stick lid lining form and preserves.
Through examining, the effect of water surface film outward appearance, matrix residual, skin tracing ability and uniformity obtained by the present embodiment is equal
It is higher.
Embodiment 4
A kind of water surface film is present embodiments provided, mainly by hydrogel matrix, myricetin, myricetrin and dihydromyricetin system
Into the mole ratio between the myricetin, myricetrin and dihydromyricetin is 1.1：1.2：1.1, wherein myricetin exists
Concentration in 100g hydrogel matrixes is 0.25 μM.
Wherein, hydrogel matrix is mainly by water, EDTA-2Na, kaolin, thickener, Sodium Polyacrylate, Dihydroxyaluminium Aminoacetate, organic
Acid and NMF are made, and wherein in hydrogel matrix, azone 1.2g, EDTA-2Na 0.1g, kaolin 1g, thickener is
0.6g, Sodium Polyacrylate 4g, Dihydroxyaluminium Aminoacetate 0.05g, tartaric acid 0.1g, NMF 15g, surplus are water.
Specifically, thickener is sodium carboxymethylcellulose and polyvinylpyrrolidone (PVP), wherein carboxymethyl cellulose
Sodium is 0.4g, polyvinylpyrrolidone 0.2g.
Specifically, NMF is glycerine and polyethylene glycol (PEG), and the wherein weight ratio of glycerine and polyethylene glycol is 18:
5, in addition in the present embodiment, organic acid is tartaric acid.
The water surface film that the present embodiment provides so is made：
(1) Sodium Polyacrylate, thickener, EDTA-2Na and Dihydroxyaluminium Aminoacetate are put into mixed grinding in mortar, after grinding
Powder and NMF are under stirring at low speed uniformly into oil phase mixed liquor.
(2) it is tartaric acid acid is soluble in water, control ph 2.38, add kaolin and polyvinylpyrrolidone and mix
Stirring, pour into afterwards in oil phase mixed liquor and be stirred together for that bare substrate is made, the pH value of obtained bare substrate is 6~7.
(3) myricetin, myricetrin and dihydromyricetin are pressed 1.1：1：1.1 ratio mixes with azone, adds blank base
Mixed, and be uniformly coated on 5 non-woven fabrics in matter.
(4) room temperature places 24h, sticks anti-stick lid lining form and preserves.
Through examining, the effect of water surface film outward appearance, matrix residual, skin tracing ability and uniformity obtained by the present embodiment is equal
It is higher.
Embodiment 5
A kind of water surface film is present embodiments provided, mainly by hydrogel matrix, myricetin, myricetrin and dihydromyricetin system
Into the mole ratio between the myricetin, myricetrin and dihydromyricetin is 1.2：1：1.2, wherein myricetin is in 100g
Concentration in hydrogel matrix is 0.3 μM.
Wherein, hydrogel matrix is mainly by water, EDTA-2Na, kaolin, thickener, Sodium Polyacrylate, Dihydroxyaluminium Aminoacetate, organic
Acid and NMF are made, and wherein in hydrogel matrix, azone 1.2g, EDTA-2Na 0.1g, kaolin 1g, thickener is
3.9g, Sodium Polyacrylate 4g, Dihydroxyaluminium Aminoacetate 0.05g, tartaric acid 0.1g, NMF 9.6g, surplus are water.
Specifically, thickener is sodium carboxymethylcellulose and polyvinylpyrrolidone (PVP), wherein carboxymethyl cellulose
Sodium is 1.3g, polyvinylpyrrolidone 0.5g.
Specifically, NMF is glycerine and polyethylene glycol (PEG), and the wherein weight ratio of glycerine and polyethylene glycol is 22:
2, in addition in the present embodiment, organic acid is tartaric acid.
The water surface film that the present embodiment provides so is made：
(1) Sodium Polyacrylate, thickener, EDTA-2Na and Dihydroxyaluminium Aminoacetate are put into mixed grinding in mortar, after grinding
Powder and NMF are under stirring at low speed uniformly into oil phase mixed liquor.
(2) it is tartaric acid acid is soluble in water, control ph 2.38, add kaolin and polyvinylpyrrolidone and mix
Stirring, pour into afterwards in oil phase mixed liquor and be stirred together for that bare substrate is made, the pH value of obtained bare substrate is 6~7.
(3) myricetin, myricetrin and dihydromyricetin are pressed 1：1：1 ratio mixes with azone, adds in bare substrate
Mixed, and be uniformly coated on 5 non-woven fabrics.
(4) room temperature places 24h, sticks anti-stick lid lining form and preserves.
Outward appearance, matrix residual, skin tracing ability and the uniformity that facial mask is carried out to water surface film made from embodiment 1-5 are entered
Row test, outward appearance：It is smooth glossy, no leak adhesive situation, wrist back is affixed on, firmly gets rid of 10 times without coming off, skin tracing ability is good,
Open repeatedly, be pasted on wrist back, be repeated 3 times, the interval time 5min for opening or pasting, observe noresidue every time, test
As a result grade 1 is met.
Water surface film made from embodiment 1-5 is tried out respectively as test group；Simultaneously according to embodiment 3 method,
Tried out as a control group with individually adding water surface film made of myricetin or myricetrin or dihydromyricetin, individually add poplar
Syphilis (control group 1) or the amount of myricetrin (control group 2) or dihydromyricetin (control group 3) are：In 100g hydrogel matrixes
Concentration be 0.15 μM.Select the Ms of 400 25-40 year to be tried out altogether, be divided into 8 groups at random altogether, every group of 50 people.Make
Use method：Use weekly twice, altogether using one month.
After the completion of use, gloss is moistened to water and crinkle-removing whitening effect is given a mark, full marks are 100 points, count score value, are taken every
Individual group of average mark, as a result as shown in table 6.
The trial effect of table 6
| Group | Water profit gloss (average mark) | Crinkle-removing whitening (average mark) |
| Embodiment 1 | 95 | 94 |
| Embodiment 2 | 96 | 97 |
| Embodiment 3 | 97 | 97 |
| Embodiment 4 | 98 | 97 |
| Embodiment 5 | 97 | 98 |
| Control group 1 | 81 | 80 |
| Control group 2 | 82 | 81 |
| Control group 3 | 83 | 84 |
Found during on probation, for control group, water surface film can significantly increase made from the embodiment of the present invention
Add H in skin2O2With SOD enzyme activities, after use, the skin preceding more aobvious water relatively on probation of trier moistens gloss, and has significantly
Crinkle-removing whitening effect, and do not have uncomfortable phenomenon on probation, by the consistent favorable comment of trier.Illustrate the facial mask pair that embodiment obtains
The cleaning of skin, skin care effect are high, and will not produce toxic side effect.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (13)
1. a kind of water surface film, it is characterised in that be mainly made up of hydrogel matrix, myricetin, myricetrin and dihydromyricetin, institute
It is 0.8~1.2 to state the mole ratio between myricetin, myricetrin and dihydromyricetin：0.8~1.2：0.8~1.2, it is described
The concentration of myricetin, myricetrin and dihydromyricetin in the hydrogel matrix is 1 μM~3 μM.
2. water surface film according to claim 1, it is characterised in that percentage, the hydrogel matrix contain
It is water 60%~68%, EDTA-2Na0~0.1%, azone 0~1.2%, kaolin 0~1%, thickener 0.6%~3.9%, poly-
PAA 4%~7%, Dihydroxyaluminium Aminoacetate 0.1%~0.25%, organic acid 0.1%~0.3% and NMF 9.6%~23%.
3. water surface film according to claim 2, it is characterised in that the thickener includes sodium carboxymethylcellulose and poly- second
Alkene pyrrolidone, percentage by weight of the sodium carboxymethylcellulose in the hydrogel matrix are 1.3%~1.7%, are gathered
Percentage by weight of the vinylpyrrolidone in the hydrogel matrix is 0.5%~0.7%.
4. water surface film according to claim 3, it is characterised in that the sodium carboxymethylcellulose is in the hydrogel matrix
In percentage by weight be 1.5%, percentage by weight of the polyvinylpyrrolidone in the hydrogel matrix be 0.6%.
5. water surface film according to claim 2, it is characterised in that the NMF includes glycerine and polyethylene glycol, described
Percentage by weight of the glycerine in the hydrogel matrix is 7.2%~18%, and the polyethylene glycol is in the hydrogel matrix
In percentage by weight be 2.4%~5%.
6. water surface film according to claim 5, it is characterised in that the Sodium Polyacrylate is in the hydrogel matrix
Percentage by weight is 5.2%, and percentage by weight of the Dihydroxyaluminium Aminoacetate in the hydrogel matrix is 0.15%, and organic acid is in the water
Percentage by weight in gel-type vehicle is 0.1%, and the weight ratio of glycerine and polyethylene glycol is 22:2.
7. water surface film according to claim 6, it is characterised in that weight of the Sodium Polyacrylate in the hydrogel matrix
Percentage is 4%~5.2%, and percentage by weight of the Dihydroxyaluminium Aminoacetate in the hydrogel matrix is 0.15%, and organic acid is described
Percentage by weight in hydrogel matrix is 0.1% or 0.3%, and the weight ratio of glycerine and polyethylene glycol is 22:2.
8. water surface film according to claim 6, it is characterised in that the organic acid is tartaric acid.
9. water surface film according to claim 1, it is characterised in that between the myricetin, myricetrin and dihydromyricetin
Mole ratio be 0.9~1.1：0.9~1.1：0.9~1.1.
10. water surface film according to claim 1, it is characterised in that between the myricetin, myricetrin and dihydromyricetin
Mole ratio be 1：1：1.
11. the preparation method of the water surface film described in any one of claim 1 to 10, it is characterised in that comprise the following steps：
(1) by Sodium Polyacrylate, thickener, EDTA-2Na and Dihydroxyaluminium Aminoacetate mixed grinding, the powder after grinding is stirred with NMF
Mix uniformly into oil phase mixed liquor；
(2) organic acid is soluble in water, it is 2~3 to control pH, adds kaolin and polyvinylpyrrolidone and mixes, it
After pour into the oil phase mixed liquor and be stirred together for that bare substrate is made, the pH of the bare substrate is 6~7；
(3) myricetin, myricetrin and dihydromyricetin are mixed with azone and adds the bare substrate mixing；It is uniformly coated on nothing
Spin on cloth；
(4) room temperature places at least 24h, sticks anti-mucous membrane and preserves.
12. the preparation method of water surface film according to claim 11, it is characterised in that in step (2), organic acid is dissolved in water
When, it is 2.2~2.5 to control pH.
13. the preparation method of water surface film according to claim 11, it is characterised in that in step (2), organic acid is dissolved in water
When, it is 2.38 to control pH.
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| CN105640792B (en) * | 2016-02-04 | 2018-08-10 | 长沙爱扬医药科技有限公司 | Dihydromyricetin is in beauty except the application in spot product |
| CN105748357A (en) * | 2016-03-16 | 2016-07-13 | 荣成市福星海产有限公司 | Laminaria japonica frond mask and preparation method thereof |
| CN105816507A (en) * | 2016-04-20 | 2016-08-03 | 中国科学院武汉植物园 | Bletilla striata callus skin care preparation and preparation method thereof |
| CN107233283A (en) * | 2017-07-06 | 2017-10-10 | 贵州九立德生物制药有限公司 | A kind of elimination pouch, hydrogel of wrinkle and preparation method thereof |
| CN108852893A (en) * | 2018-08-24 | 2018-11-23 | 恩施西特优生态农业开发有限公司 | Tea polyphenols facial mask and preparation method thereof |
| CN110638809B (en) * | 2019-11-13 | 2022-11-29 | 浙江万里学院 | Composition with whitening effect |
| CN110859793B (en) * | 2019-12-24 | 2022-01-14 | 广州市和一医疗科技有限公司 | High-affinity gel mask and preparation method thereof |
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| CN1399916A (en) * | 2002-08-30 | 2003-03-05 | 张友胜 | Application of dihydromyricetin in preparation of food, cosmetics or medicine |
| CN1457775A (en) * | 2003-05-30 | 2003-11-26 | 任启生 | Composition containing dihydro myricitrin and myricitrin |
| CN1731978A (en) * | 2002-12-27 | 2006-02-08 | 株式会社韩国新药 | Extract of cercis chinensis having anti-oxidant activity and anti-aging activity, and cosmetical composition containing the extract for anti-oxidation, skin-aging protection and wrinkle improvement |
| CN102626401A (en) * | 2012-04-28 | 2012-08-08 | 佛山拜澳生物科技有限公司 | Hydrogel paste and preparation method thereof |
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|---|---|---|---|---|
| CN1399916A (en) * | 2002-08-30 | 2003-03-05 | 张友胜 | Application of dihydromyricetin in preparation of food, cosmetics or medicine |
| CN1731978A (en) * | 2002-12-27 | 2006-02-08 | 株式会社韩国新药 | Extract of cercis chinensis having anti-oxidant activity and anti-aging activity, and cosmetical composition containing the extract for anti-oxidation, skin-aging protection and wrinkle improvement |
| CN1457775A (en) * | 2003-05-30 | 2003-11-26 | 任启生 | Composition containing dihydro myricitrin and myricitrin |
| CN102626401A (en) * | 2012-04-28 | 2012-08-08 | 佛山拜澳生物科技有限公司 | Hydrogel paste and preparation method thereof |
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