CN105228650B - 用于hiv预防和治疗的聚糖修饰的抗-cd4抗体 - Google Patents

用于hiv预防和治疗的聚糖修饰的抗-cd4抗体 Download PDF

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Publication number
CN105228650B
CN105228650B CN201380073311.4A CN201380073311A CN105228650B CN 105228650 B CN105228650 B CN 105228650B CN 201380073311 A CN201380073311 A CN 201380073311A CN 105228650 B CN105228650 B CN 105228650B
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antibody
ibalizumab
amino acid
hiv
seq
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CN105228650A (zh
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R·宋
D·D·贺
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Rockefeller University
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Rockefeller University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201380073311.4A 2012-12-18 2013-12-18 用于hiv预防和治疗的聚糖修饰的抗-cd4抗体 Active CN105228650B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261738777P 2012-12-18 2012-12-18
US61/738,777 2012-12-18
US201361864942P 2013-08-12 2013-08-12
US61/864,942 2013-08-12
PCT/US2013/076051 WO2014100139A1 (en) 2012-12-18 2013-12-18 Glycan-modified anti-cd4 antibodies for hiv prevention and therapy

Publications (2)

Publication Number Publication Date
CN105228650A CN105228650A (zh) 2016-01-06
CN105228650B true CN105228650B (zh) 2018-11-16

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CN201380073311.4A Active CN105228650B (zh) 2012-12-18 2013-12-18 用于hiv预防和治疗的聚糖修饰的抗-cd4抗体

Country Status (7)

Country Link
US (1) US9790276B2 (cg-RX-API-DMAC7.html)
EP (1) EP2934589B1 (cg-RX-API-DMAC7.html)
JP (1) JP6408487B2 (cg-RX-API-DMAC7.html)
CN (1) CN105228650B (cg-RX-API-DMAC7.html)
ES (1) ES2862950T3 (cg-RX-API-DMAC7.html)
TW (1) TWI630215B (cg-RX-API-DMAC7.html)
WO (1) WO2014100139A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9587022B2 (en) 2012-12-18 2017-03-07 The Rockefeller University Glycan-modified anti-CD4 antibody with improved HIV-1 neutralizing activity
US10308707B2 (en) 2013-12-02 2019-06-04 Aaron Diamond Aids Research Center Bispecific HIV-1-neutralizing antibodies
EP3077051B1 (en) 2013-12-02 2023-04-12 The Trustees of Columbia University in the City of New York Improved hiv-1-neutralizing antibody potency and breadth via cell receptor anchoring using bispecific antibodies with native architecture
CA2977106A1 (en) * 2015-02-27 2016-09-01 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof
CA3001131A1 (en) 2015-11-02 2017-05-11 Five Prime Therapeutics, Inc. Cd80 extracellular domain polypeptides and their use in cancer treatment
CN111247171A (zh) 2017-10-14 2020-06-05 西托姆克斯治疗公司 抗体、可活化抗体、双特异性抗体和双特异性可活化抗体及其使用方法
TWI845745B (zh) * 2019-08-19 2024-06-21 洛克菲勒大學 具改良藥物動力學之經酸鹼度依賴性抗原結合活性工程化之抗人類免疫缺乏病毒抗體

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20120121597A1 (en) * 2010-11-12 2012-05-17 The Rockefeller University Fusion proteins for hiv therapy

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GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
DE69126301T2 (de) 1990-11-27 1998-01-02 Biogen, Inc., Cambridge, Mass. Hiv-induzierte synzytien blockierender anti-cd-4-antikörper
JP4334141B2 (ja) 1998-04-20 2009-09-30 グリカート バイオテクノロジー アクチェンゲゼルシャフト 抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US7029872B2 (en) 2000-06-28 2006-04-18 Glycofi, Inc Methods for producing modified glycoproteins
AU2006247039B2 (en) * 2005-05-19 2011-03-03 Amgen Inc. Compositions and methods for increasing the stability of antibodies
CA2632828C (en) 2005-12-12 2012-07-10 F. Hoffmann-La Roche Ag Antibodies against amyloid beta with glycosylation in the variable region
EP3067368A1 (en) 2007-04-27 2016-09-14 Genentech, Inc. Potent, stable and non-immunosuppressive anti-cd4 antibodies
JP5688734B2 (ja) * 2008-12-12 2015-03-25 国立大学法人 東京大学 移植片対腫瘍効果を保存した免疫学的再構築促進剤または感染症予防剤
WO2011116387A1 (en) * 2010-03-19 2011-09-22 Tetragenetics, Inc. Production of aglycosylated monoclonal antibodies in ciliates
US9587022B2 (en) 2012-12-18 2017-03-07 The Rockefeller University Glycan-modified anti-CD4 antibody with improved HIV-1 neutralizing activity

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US20120121597A1 (en) * 2010-11-12 2012-05-17 The Rockefeller University Fusion proteins for hiv therapy

Non-Patent Citations (4)

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Title
Engineering a Unique Glycosylation Site for Site-Specific Conjugation of Haptens to Antibody Fragments;Shui-on Leung等;《The Journal of Immunology》;19950601;第154卷(第11期);第5920页左栏最后1段，第5923页左栏第1段，第5924页左栏第1段，第5925页左栏第2段 *
Loss of Asparagine-Linked Glycosylation Sites in Variable Region 5 of Human Immunodeficiency Virus Type 1 Envelope Is Associated with Resistance to CD4 Antibody Ibalizumab;Jonathan Toma等;《JOURNAL OF VIROLOGY》;20110202;第85卷(第8期);第3872–3880页 *
Shui-on Leung等.Engineering a Unique Glycosylation Site for Site-Specific Conjugation of Haptens to Antibody Fragments.《The Journal of Immunology》.1995,第154卷(第11期),第5920页左栏第2段，第5923页左栏第1段，第5924页第1段，第5925页左栏第2段. *
Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1–neutralizing activity;Ruijiang Song等;《nature biotechnology》;20131006;第31卷(第11期);第1048页左栏第4段、Online methods第2段 *

Also Published As

Publication number Publication date
TW201441258A (zh) 2014-11-01
JP2016503059A (ja) 2016-02-01
US20160362493A9 (en) 2016-12-15
WO2014100139A1 (en) 2014-06-26
ES2862950T3 (es) 2021-10-08
EP2934589A1 (en) 2015-10-28
US20150166662A1 (en) 2015-06-18
EP2934589A4 (en) 2016-08-10
EP2934589B1 (en) 2021-01-13
US9790276B2 (en) 2017-10-17
TWI630215B (zh) 2018-07-21
CN105228650A (zh) 2016-01-06
JP6408487B2 (ja) 2018-10-24

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