CN105228616B - 抗前蛋白转化酶枯草杆菌蛋白酶Kexin 9型（抗PCSK9）化合物及其用于治疗和/或预防心血管疾病的方法 - Google Patents

抗前蛋白转化酶枯草杆菌蛋白酶Kexin 9型（抗PCSK9）化合物及其用于治疗和/或预防心血管疾病的方法 Download PDF

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CN105228616B
CN105228616B CN201480016193.8A CN201480016193A CN105228616B CN 105228616 B CN105228616 B CN 105228616B CN 201480016193 A CN201480016193 A CN 201480016193A CN 105228616 B CN105228616 B CN 105228616B
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pcsk9
alkyl
base
group
amino
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CN105228616A (zh
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谢林·萨拉赫丁·阿卜杜勒-马吉德
纳比勒·艾尔斯霍尔巴吉
哈罗德·迈耶斯
沙克尔·A·穆萨
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Shifa Biomedical Corp
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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CN201480016193.8A 2013-03-15 2014-03-11 抗前蛋白转化酶枯草杆菌蛋白酶Kexin 9型（抗PCSK9）化合物及其用于治疗和/或预防心血管疾病的方法 Expired - Fee Related CN105228616B (zh)

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US201361788061P 2013-03-15 2013-03-15
US61/788,061 2013-03-15
PCT/US2014/022957 WO2014150326A1 (en) 2013-03-15 2014-03-11 Anti-proprotein convertase subtilisin kexin type 9 (anti-pcsk9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases

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CN105228616B true CN105228616B (zh) 2019-05-03

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US (1) US20160256467A1 (OSRAM)
EP (1) EP2968266B1 (OSRAM)
JP (2) JP2016512825A (OSRAM)
CN (1) CN105228616B (OSRAM)
AU (1) AU2014237312B2 (OSRAM)
BR (1) BR112015023294A2 (OSRAM)
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CA2904660A1 (en) 2014-09-25
BR112015023294A2 (pt) 2017-07-18
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EP2968266A1 (en) 2016-01-20
US20160256467A1 (en) 2016-09-08
CN105228616A (zh) 2016-01-06
EP2968266A4 (en) 2016-09-07

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