CN105214136A - Filling material of bone and preparation method thereof - Google Patents
Filling material of bone and preparation method thereof Download PDFInfo
- Publication number
- CN105214136A CN105214136A CN201510638474.3A CN201510638474A CN105214136A CN 105214136 A CN105214136 A CN 105214136A CN 201510638474 A CN201510638474 A CN 201510638474A CN 105214136 A CN105214136 A CN 105214136A
- Authority
- CN
- China
- Prior art keywords
- parts
- bone
- filling material
- paris white
- polysulfones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of filling material of bone and preparation method thereof, filling material of bone comprises the raw material of following parts by weight: hydroxyapatite 40 ~ 90 parts, titanium dioxide 10 ~ 50 parts, polysulfones 40 ~ 80 parts, tricalcium phosphate 20 ~ 30 parts, dalcium biphosphate 30 ~ 50 parts, silica 10 ~ 50 part, sodium oxide 40 ~ 80 parts, polymethyl methacrylate 10 ~ 50 parts, Paris white 40 ~ 90 parts.Its preparation method is: grinding after hydroxyapatite, titanium dioxide, polysulfones, tricalcium phosphate, dalcium biphosphate, silicon dioxide, sodium oxide mixing is evenly obtained compound, be warming up to 1400 ~ 1600 DEG C of reaction 1 ~ 2h, Paris white and polymethyl methacrylate is added after pulverizing, mix homogeneously.The porosity of gained filling material of bone of the present invention is high, can promote the absorption of Paris white, and the calcium ion in Paris white improves the inducibility to osteogenesis further, contributes to bone heals growth.
Description
Technical field
The present invention relates to a kind of filling material of bone and preparation method thereof.
Background technology
Filling material of bone is in order to filling bone defect chamber or the material in space between bone implanting part and bone bed.Its effect accelerates bone defect healing or bone implanting part is fixed.
CN200510084975.8 discloses the Bioabsorbable polymeric granular porous bone filling material that particle diameter is 100-3000 μm, its for when the defect portion after filling lesion removal or after autologous bone transplanting and implanted tooth for reinforcing or filling dental bed, this filling material of bone is by mixing the particle-like substance of diameter 100-2000 μm with the solution that wherein bioresorbable polymer is dissolved in organic solvent, this particle-like substance is insoluble to organic solvent and is dissolved in the liquid not dissolving bioresorbable polymer, freezing, dry to remove organic solvent, by obtained material disintegrating, particle-like substance is dissolved in liquid be removed, and sieve and obtained comprise particle-like substance and the polymeric material having that aperture is the aperture structure of 5-50 μm.Though the aperture of this filling material of bone is little, but porosity is lower.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, provide a kind of filling material of bone and preparation method thereof, porosity is high.
The present invention is by the following technical solutions:
Filling material of bone, comprises the raw material of following parts by weight: hydroxyapatite 40 ~ 90 parts, titanium dioxide 10 ~ 50 parts, polysulfones 40 ~ 80 parts, tricalcium phosphate 20 ~ 30 parts, dalcium biphosphate 30 ~ 50 parts, silica 10 ~ 50 part, sodium oxide 40 ~ 80 parts, polymethyl methacrylate 10 ~ 50 parts, Paris white 40 ~ 90 parts.
As preferably, filling material of bone, comprises the raw material of following parts by weight: hydroxyapatite 60 parts, titanium dioxide 30 parts, polysulfones 60 parts, tricalcium phosphate 25 parts, dalcium biphosphate 40 parts, silicon dioxide 30 parts, sodium oxide 60 parts, polymethyl methacrylate 30 parts, Paris white 60 parts.
As preferably, the particle diameter of Paris white is 1 ~ 3 μm.
The preparation method of above-mentioned filling material of bone, comprise the following steps: grinding after hydroxyapatite, titanium dioxide, polysulfones, tricalcium phosphate, dalcium biphosphate, silicon dioxide, sodium oxide mixing is evenly obtained compound, be warming up to 1400 ~ 1600 DEG C of reaction 1 ~ 2h, Paris white and polymethyl methacrylate is added after pulverizing, mix homogeneously.
As preferably, be warming up to 1500 DEG C of reaction 1.5h.
beneficial effect
Porosity of the present invention is high, can promote the absorption of Paris white, and the calcium ion in Paris white improves the inducibility to osteogenesis further, contributes to bone heals growth.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described in detail.
embodiment 1
Filling material of bone, comprises the raw material of following parts by weight: hydroxyapatite 60 parts, titanium dioxide 30 parts, polysulfones 60 parts, tricalcium phosphate 25 parts, dalcium biphosphate 40 parts, silicon dioxide 30 parts, sodium oxide 60 parts, polymethyl methacrylate 30 parts, Paris white 60 parts.
The particle diameter of Paris white is 2 μm.
The preparation method of above-mentioned filling material of bone, comprise the following steps: grinding after hydroxyapatite, titanium dioxide, polysulfones, tricalcium phosphate, dalcium biphosphate, silicon dioxide, sodium oxide mixing is evenly obtained compound, be warming up to 1500 DEG C of reaction 1.5h, Paris white and polymethyl methacrylate is added after pulverizing, mix homogeneously.
embodiment 2
Filling material of bone, comprises the raw material of following parts by weight: hydroxyapatite 40 parts, titanium dioxide 10 parts, polysulfones 40 parts, tricalcium phosphate 20 parts, dalcium biphosphate 30 parts, silica 10 part, sodium oxide 40 parts, polymethyl methacrylate 10 parts, Paris white 40 parts.
The particle diameter of Paris white is 1 μm.
The preparation method of above-mentioned filling material of bone, comprise the following steps: grinding after hydroxyapatite, titanium dioxide, polysulfones, tricalcium phosphate, dalcium biphosphate, silicon dioxide, sodium oxide mixing is evenly obtained compound, be warming up to 1400 DEG C of reaction 1h, Paris white and polymethyl methacrylate is added after pulverizing, mix homogeneously.
embodiment 3
Filling material of bone, comprises the raw material of following parts by weight: hydroxyapatite 90 parts, titanium dioxide 50 parts, polysulfones 80 parts, tricalcium phosphate 30 parts, dalcium biphosphate 50 parts, silicon dioxide 50 parts, sodium oxide 80 parts, polymethyl methacrylate 50 parts, Paris white 90 parts.
The particle diameter of Paris white is 3 μm.
The preparation method of above-mentioned filling material of bone, comprise the following steps: grinding after hydroxyapatite, titanium dioxide, polysulfones, tricalcium phosphate, dalcium biphosphate, silicon dioxide, sodium oxide mixing is evenly obtained compound, be warming up to 1600 DEG C of reaction 2h, Paris white and polymethyl methacrylate is added after pulverizing, mix homogeneously.
comparative example 1
Identical with embodiment 1, difference is: do not add Paris white and polymethyl methacrylate.
performance test
The product of Example 1 ~ 4 and comparative example 1, measures porosity, the results are shown in Table 1.
Table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Comparative example 1 | |
| Porosity % | 92 | 91 | 89 | 89 | 71 |
Conclusion: porosity of the present invention, up to 92%, can promote the absorption of Paris white, and the calcium ion in Paris white improves the inducibility to osteogenesis further, contributes to bone heals growth.
Claims (5)
1. filling material of bone, it is characterized in that, comprise the raw material of following parts by weight: hydroxyapatite 40 ~ 90 parts, titanium dioxide 10 ~ 50 parts, polysulfones 40 ~ 80 parts, tricalcium phosphate 20 ~ 30 parts, dalcium biphosphate 30 ~ 50 parts, silica 10 ~ 50 part, sodium oxide 40 ~ 80 parts, polymethyl methacrylate 10 ~ 50 parts, Paris white 40 ~ 90 parts.
2. filling material of bone according to claim 1, it is characterized in that, comprise the raw material of following parts by weight: hydroxyapatite 60 parts, titanium dioxide 30 parts, polysulfones 60 parts, tricalcium phosphate 25 parts, dalcium biphosphate 40 parts, silicon dioxide 30 parts, sodium oxide 60 parts, polymethyl methacrylate 30 parts, Paris white 60 parts.
3. filling material of bone according to claim 1, is characterized in that, the particle diameter of Paris white is 1 ~ 3 μm.
4. based on the preparation method of filling material of bone according to claim 1, it is characterized in that, comprise the following steps: grinding after hydroxyapatite, titanium dioxide, polysulfones, tricalcium phosphate, dalcium biphosphate, silicon dioxide, sodium oxide mixing is evenly obtained compound, be warming up to 1400 ~ 1600 DEG C of reaction 1 ~ 2h, Paris white and polymethyl methacrylate is added after pulverizing, mix homogeneously.
5. the preparation method of filling material of bone according to claim 4, is characterized in that, is warming up to 1500 DEG C of reaction 1.5h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510638474.3A CN105214136A (en) | 2015-09-30 | 2015-09-30 | Filling material of bone and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510638474.3A CN105214136A (en) | 2015-09-30 | 2015-09-30 | Filling material of bone and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105214136A true CN105214136A (en) | 2016-01-06 |
Family
ID=54983639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510638474.3A Pending CN105214136A (en) | 2015-09-30 | 2015-09-30 | Filling material of bone and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105214136A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920663A (en) * | 2016-04-27 | 2016-09-07 | 苏州蔻美新材料有限公司 | Bone defect repair material and preparation method thereof |
| CN108815576A (en) * | 2018-07-06 | 2018-11-16 | 宣城南巡智能科技有限公司 | A kind of compound extracellular matrix material and its preparation process |
| CN117624634A (en) * | 2024-01-25 | 2024-03-01 | 吉林省汇融生物科技有限公司 | Polysulfone hydroxyapatite polymer and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102203175A (en) * | 2008-10-17 | 2011-09-28 | 伊维博有限公司 | Polymeric materials |
| WO2014146831A1 (en) * | 2013-03-21 | 2014-09-25 | Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der BAM, Bundesanstalt für Materialforschung und -prüfung | Sinterable and/or fusible ceramic mass, production and use thereof |
| CN104876439A (en) * | 2006-06-16 | 2015-09-02 | 帝国创新有限公司 | Bioactive glass |
-
2015
- 2015-09-30 CN CN201510638474.3A patent/CN105214136A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104876439A (en) * | 2006-06-16 | 2015-09-02 | 帝国创新有限公司 | Bioactive glass |
| CN102203175A (en) * | 2008-10-17 | 2011-09-28 | 伊维博有限公司 | Polymeric materials |
| WO2014146831A1 (en) * | 2013-03-21 | 2014-09-25 | Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der BAM, Bundesanstalt für Materialforschung und -prüfung | Sinterable and/or fusible ceramic mass, production and use thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920663A (en) * | 2016-04-27 | 2016-09-07 | 苏州蔻美新材料有限公司 | Bone defect repair material and preparation method thereof |
| CN108815576A (en) * | 2018-07-06 | 2018-11-16 | 宣城南巡智能科技有限公司 | A kind of compound extracellular matrix material and its preparation process |
| CN117624634A (en) * | 2024-01-25 | 2024-03-01 | 吉林省汇融生物科技有限公司 | Polysulfone hydroxyapatite polymer and preparation method and application thereof |
| CN117624634B (en) * | 2024-01-25 | 2024-04-12 | 吉林省汇融生物科技有限公司 | Polysulfone hydroxyapatite polymer and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11590263B2 (en) | Osteoinductive calcium phosphates | |
| JP5759370B2 (en) | Three-dimensional matrix of monetite with structured porosity for tissue engineering and bone regeneration, and method for preparing the three-dimensional matrix | |
| US9066995B2 (en) | Bone substitute material | |
| CN105214136A (en) | Filling material of bone and preparation method thereof | |
| US20230158213A1 (en) | Osteoinductive Calcium Phosphates | |
| US20110020419A1 (en) | Osteoinductive calcium phosphates | |
| RU2017120359A (en) | INDUCTION OF OSTEOGENESIS BY INTRODUCING RNA CODING BONE MORPHOGENETIC PROTEIN (KMB) | |
| CN107469152B (en) | Bone tissue repair composite material, preparation method thereof and bone tissue repair structural body prepared from bone tissue repair composite material | |
| JP6288723B2 (en) | Bone regeneration material kit, paste-like bone regeneration material, bone regeneration material and bone cement | |
| Pan et al. | Engineered macroporous hydrogel scaffolds via pickering emulsions stabilized by MgO nanoparticles promote bone regeneration | |
| Xiao et al. | Fabrication of a Cu/Zn co-incorporated calcium phosphate scaffold-derived GDF-5 sustained release system with enhanced angiogenesis and osteogenesis properties | |
| KR101268408B1 (en) | Composition and Manufacturing method for porous calcium phosphate granules by physical foaming | |
| CN109498846A (en) | Bone repairing support and preparation method thereof that is a kind of while discharging zinc ion and strontium ion | |
| JP2018523632A (en) | Large three-dimensional porous scaffold material made from active hydroxyapatite obtained by transformation resembling the morphology of a natural structure organism and process for obtaining it | |
| CN109106984B (en) | Hydroxyapatite porous scaffold and preparation method thereof | |
| US10517993B2 (en) | Porous composite, bone regeneration material, and method for producing porous composite | |
| US10155069B2 (en) | Bone graft with a tannin-hydroxyapatite scaffold and stem cells for bone engineering | |
| RU2554811C1 (en) | Method of obtaining porous chitosan calcium phosphate-containing sponges for filling bone defects | |
| RU2494721C1 (en) | Biocompatible bone-substituting material and method of obtaining thereof | |
| KR20200050477A (en) | Antibacterial calcium-based materials | |
| CN106267365A (en) | A kind of enhancing activity injecting bone cement and preparation method thereof | |
| CN105214137A (en) | Bone renovating material and preparation method thereof | |
| WO2016052502A1 (en) | Method for producing calcium carbonate blocks | |
| JP2014124416A (en) | Bone regeneration material kit, pasty bone regeneration material, bone regeneration material and bone junction material | |
| CN109091703B (en) | Rare earth element doped white phosphorus ore/gelatin three-dimensional porous composite material, and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160106 |
|
| RJ01 | Rejection of invention patent application after publication |