WO2016052502A1 - Method for producing calcium carbonate blocks - Google Patents
Method for producing calcium carbonate blocks Download PDFInfo
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- WO2016052502A1 WO2016052502A1 PCT/JP2015/077513 JP2015077513W WO2016052502A1 WO 2016052502 A1 WO2016052502 A1 WO 2016052502A1 JP 2015077513 W JP2015077513 W JP 2015077513W WO 2016052502 A1 WO2016052502 A1 WO 2016052502A1
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- Prior art keywords
- block
- calcium carbonate
- carbonate
- calcium
- calcium hydroxide
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Classifications
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F11/00—Compounds of calcium, strontium, or barium
- C01F11/18—Carbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
Definitions
- the present invention relates to a method for producing a calcium carbonate block useful as a raw material for artificial bone.
- the types of bone prosthetic materials can be divided into other family bones collected from corpses, heterogeneous bones collected from other animals such as cattle, and chemically synthesized artificial bones.
- artificial bones have been developed because they are superior in that there is no possibility of infectious diseases due to the contamination of these factors.
- a ceramic artificial bone mainly composed of calcium phosphate As the artificial bone, a ceramic artificial bone mainly composed of calcium phosphate is known, and the most studied material is hydroxyapatite. Hydroxyapatite is an extremely useful bone prosthetic material because it exhibits osteoconductivity, but it does not disappear because it is a non-bioabsorbable material, and remains semi-permanently as a foreign substance. As a result, there is a possibility of leakage from the defect after filling, and there is a possibility of causing inflammation due to infection of the transplant, and therefore a bioabsorbable bone filling material has been desired.
- ⁇ -TCP ⁇ -type tricalcium phosphate
- Patent Document 1 a ceramic artificial bone made of ⁇ -type tricalcium phosphate ( ⁇ -TCP), which is a bioabsorbable material, has been developed (for example, see Patent Document 1). Since this artificial bone is excellent in bioresorbability, it will eventually disappear. However, the mechanism of resorption is not due to the mechanism of living organisms such as physicochemical dissolution, so if the bone defect is large, the artificial bone may disappear before sufficient bone formation is performed. there were.
- ⁇ -TCP ⁇ -type tricalcium phosphate
- carbonate apatite has been recently developed as a bone prosthetic material that is absorbed by the mechanism of the living body (for example, Patent Document 2). Since carbonate apatite has a composition similar to that of living bone, it is absorbed by the mechanism of the living body. For this reason, since bone formation by osteoblasts and resorption (remodeling) of the bone filling material by osteoclasts are appropriately performed, bone repair with high predictability is possible.
- Patent Document 2 As a method for producing carbonate apatite, a method of immersing a calcium carbonate precursor in a phosphate solution is effective (for example, Patent Document 2).
- the bone grafting material size is below a certain level, for example, it is powdered, the living body will recognize it as a foreign substance and cause inflammation. Unless it is carbonate apatite, it cannot be applied to living bodies.
- a large block shape or the like is preferable because it can deal with a large bone defect portion or the like.
- a large block calcium carbonate is required as a precursor.
- calcium carbonate is in a powder form and needs to be artificially formed into a block shape.
- calcium carbonate is decomposed when sintered, and thus cannot be applied.
- a calcium carbonate block generally called artificial marble (for example, see Patent Document 3) in which an inorganic filler such as calcium carbonate is bonded and cured with an organic or inorganic binder has an adverse effect on the human body. Since there is a possibility that impurities which may be given remain, it is not applicable.
- a calcium carbonate block is obtained by compressing and molding the calcium hydroxide powder, and carbonating the obtained green compact by carbon dioxide gas flow with a relative humidity of 100%.
- calcium hydroxide is available as a safe substance such as the Japanese Pharmacopoeia, there is no problem of biological safety, and since the powder is bonded together with carbonation and becomes a block having strength, It is possible to obtain a calcium carbonate block.
- JP-A-5-237178 Japanese Patent No. 4854300 JP-A-8-290949
- Patent Document 2 is not practical due to the slow carbonation rate. For example, even if the size is 0.1 cm in diameter and the thickness is 0.1 cm or more, it is necessary to spend a long time (for example, 168 hours) in order to complete carbonation. Further, in the case of a diameter of 1 cm and a thickness of 1 cm or more, the carbonation of the central portion was not completed even if it took a longer time (for example, 672 hours). For this reason, calcium hydroxide remains in the central portion of the obtained calcium carbonate block, and there is a problem that the central portion of the block does not become carbonate apatite when it is converted to carbonate apatite in the next step.
- the present invention is a method for producing a calcium carbonate block applicable as a raw material for artificial bones that requires biological safety, and has a diameter of 0.1 cm and a thickness of 0.1 cm or more, and does not contain impurities. It is an object to provide a method for manufacturing a block.
- the inventors of the present invention formed calcium hydroxide into a block shape, and contacted it with carbon dioxide to partially carbonate the surface of the block. If immersed in the aqueous solution contained, even if unreacted calcium hydroxide remains, it reacts with carbonate ions in the solution to become calcium carbonate, so that the diameter is 0.1 cm and the thickness is 0.1 cm or more. Thus, the present invention was completed by finding that a calcium carbonate block containing no impurities can be reliably obtained.
- the first embodiment of the present invention is (A) Calcium hydroxide block forming step (b) Carbon dioxide contact step (c) A method for producing a calcium carbonate block including a carbonate ion-containing aqueous solution immersion step.
- the second embodiment of the present invention is (A) calcium hydroxide block molding step (b) carbon dioxide contact step (c) carbonate ion-containing aqueous solution immersion step, (D) A method for producing a calcium carbonate block including a pore-forming substance mixing step (e) a pore-forming step.
- the method for producing a calcium carbonate block according to the present invention is a method for producing a calcium carbonate block that can be applied as a raw material for artificial bones that require biosafety, and has a diameter of 0.1 cm and a thickness of 0.1 cm or more.
- the calcium hydroxide block forming step is a step of forming calcium hydroxide, which is a precursor of calcium carbonate, into a block shape. Since calcium hydroxide is usually obtained as a powder, it can be made into a block shape by filling the calcium hydroxide powder into a compression mold and compressing it using a compression molder. By controlling the molding pressure, the strength of the resulting block can be changed. The molding pressure is preferably 10 to 300 kg / cm 2 .
- the block shape can also be obtained by mixing calcium hydroxide powder with a solvent such as water and then removing the solvent.
- the size of the block to be molded is preferably 0.1 to 50 cm in diameter and 0.1 to 5 cm in thickness, particularly 3 to 10 cm in diameter and 1 to 2 cm in thickness. Examples of the shape of the block include a cylinder, a rectangular parallelepiped, a flat plate, and the like.
- the raw material calcium hydroxide can be used without any particular limitation as long as it does not contain impurities, but it is particularly preferable if it is from the Japanese Pharmacopoeia because safety is guaranteed. It is also possible to mix calcium hydroxide with another substance to form a block shape. For example, hydroxyapatite, ⁇ -type tricalcium phosphate, calcium sulfate and the like can be mixed.
- the pore-forming substance mixing step is a step of mixing a substance (pore-forming substance) that dissolves in a specific solvent into the raw material calcium hydroxide.
- the mixing ratio of calcium hydroxide and pore-forming substance is preferably 2: 1 to 1: 2.
- the size of the pore-forming substance is preferably 50 ⁇ m to 300 ⁇ m.
- Specific solvents include water, and substances that dissolve in water include sodium chloride and trisodium citrate.
- the carbon dioxide contact step is a step in which the calcium hydroxide block obtained in the (a) calcium hydroxide block molding step is brought into contact with carbon dioxide and carbonized.
- calcium hydroxide becomes calcium carbonate by reacting with carbon dioxide.
- the reaction time is set to a long time (for example, 672 hours). Even in this case, there is a possibility that calcium hydroxide may remain in the central portion.
- Examples of a method for realizing a carbonation atmosphere include a method using a carbonic acid incubator.
- Carbonation conditions depend on the block size, molding pressure, and the like, but by using a carbonic acid incubator, carbonation conditions such as carbon dioxide concentration, relative humidity, and temperature can be appropriately controlled.
- the carbonation conditions are preferably 5% to 20% as the carbon dioxide concentration, 90% to 100% relative humidity, and 20 ° C to 40 ° C.
- the carbonation time is, for example, 1 hour to 168 hours.
- the carbonate ion-containing aqueous solution immersion step is a step of immersing the partial calcium carbonate block obtained in the (b) carbon dioxide contact step in the carbonate ion-containing aqueous solution.
- the immersion time is, for example, 1 hour to 168 hours.
- the carbonate ion supplying substance is not particularly limited as long as it does not contain impurities and can be dissolved in water, but it is particularly preferable if it is a substance of the Japanese Pharmacopoeia because safety is guaranteed.
- sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, ammonium carbonate, ammonium hydrogen carbonate and the like can be mentioned.
- a higher temperature of the aqueous solution is desirable because the carbonation efficiency is high and the reaction proceeds quickly. More specifically, it is preferably 20 ° C.
- the carbonate ion concentration in the aqueous solution is not particularly specified, but a higher one is preferable because the carbonation efficiency is high and the reaction proceeds quickly.
- the carbonate ion concentration is preferably 0.5 mol / L to 1.5 mol / L.
- the hole forming step is a step of dissolving a substance dissolved in the specific solvent mixed in the (d) hole forming substance mixing step with the specific solvent.
- the calcium carbonate block obtained by the method for producing a calcium carbonate block according to the present invention is a calcium carbonate block that does not contain impurities as described above, it does not contain impurities if this is immersed in a phosphate solution and reacted. , A large carbonate apatite block is obtained.
- a porous calcium carbonate block can be obtained by including (d) a pore-forming substance mixing step and (e) a pore-forming step, and similarly a porous carbonate apatite block can be obtained.
- Example 1 10 g of calcium hydroxide from the Japanese Pharmacopoeia was uniaxially pressed using a circular mold having a diameter of 30 mm at an axial pressure of 50 kg / cm 2 to form a calcium hydroxide compact.
- the obtained calcium hydroxide compact was left standing in a carbonic acid incubator having a carbon dioxide gas concentration of 5%, a relative humidity of 100%, and a temperature of 30 ° C., and carbonized for 24 hours.
- the obtained partial calcium carbonate block was immersed in a 1 mol / L sodium hydrogen carbonate aqueous solution at 80 ° C., and after 48 hours, washed with water and dried.
- the obtained calcium carbonate block was divided and a phenolphthalein solution was added dropwise to the exposed center portion, the white color of the calcium carbonate remained and no coloration was observed. This confirmed that no unreacted calcium hydroxide remained.
- Example 2 5 g of Japanese Pharmacopoeia calcium hydroxide and 5 g of Japanese Pharmacopoeia sodium chloride with an average particle size of 300 ⁇ m were uniformly mixed using a V-type mixer.
- the obtained mixed powder was uniaxially pressed using a circular mold having a diameter of 30 mm at an axial pressure of 100 kg / cm 2 to form a calcium hydroxide / sodium chloride green compact.
- the obtained calcium hydroxide / sodium chloride compact was allowed to stand in a carbonic acid incubator having a carbon dioxide concentration of 20%, a relative humidity of 100%, and a temperature of 30 ° C., and carbonized for 24 hours.
- the obtained partial calcium carbonate / sodium chloride block was substituted and washed five times with distilled water to remove sodium chloride.
- the obtained porous partial calcium carbonate block was immersed in a 0.5 mol / L ammonium carbonate aqueous solution at 100 ° C., and after 48 hours, washed with water and dried.
- a phenolphthalein solution was added dropwise to the exposed center, no coloration was observed with the white color of calcium carbonate. This confirmed that no unreacted calcium hydroxide remained.
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Abstract
Description
(a)水酸化カルシウムブロック成形工程
(b)二酸化炭素接触工程
(c)炭酸イオン含有水溶液浸漬工程
を含む炭酸カルシウムブロックの製造方法である。 That is, the first embodiment of the present invention is
(A) Calcium hydroxide block forming step (b) Carbon dioxide contact step (c) A method for producing a calcium carbonate block including a carbonate ion-containing aqueous solution immersion step.
(a)水酸化カルシウムブロック成形工程
(b)二酸化炭素接触工程
(c)炭酸イオン含有水溶液浸漬工程
を含み、さらに、
(d)孔形成物質混合工程
(e)孔形成工程
を含む炭酸カルシウムブロックの製造方法である。 The second embodiment of the present invention is
(A) calcium hydroxide block molding step (b) carbon dioxide contact step (c) carbonate ion-containing aqueous solution immersion step,
(D) A method for producing a calcium carbonate block including a pore-forming substance mixing step (e) a pore-forming step.
また、水酸化カルシウム粉末を水等の溶媒を混ぜた後、溶媒を除去することによってもブロック形状とすることができる。
成型するブロックのサイズとしては、直径0.1cm~50cm、厚み0.1cm~5cm、特に直径3cm~10cm、厚み1cm~2cmが好ましい。またブロックの形状としては、円柱、直方体、平板状、等を挙げることができる。 (A) The calcium hydroxide block forming step is a step of forming calcium hydroxide, which is a precursor of calcium carbonate, into a block shape. Since calcium hydroxide is usually obtained as a powder, it can be made into a block shape by filling the calcium hydroxide powder into a compression mold and compressing it using a compression molder. By controlling the molding pressure, the strength of the resulting block can be changed. The molding pressure is preferably 10 to 300 kg / cm 2 .
The block shape can also be obtained by mixing calcium hydroxide powder with a solvent such as water and then removing the solvent.
The size of the block to be molded is preferably 0.1 to 50 cm in diameter and 0.1 to 5 cm in thickness, particularly 3 to 10 cm in diameter and 1 to 2 cm in thickness. Examples of the shape of the block include a cylinder, a rectangular parallelepiped, a flat plate, and the like.
日本薬局方の水酸化カルシウム10gを50kg/cm2の軸圧で直径30mmの円形金型を用いて、一軸加圧成形し、水酸化カルシウム圧粉体を成形した。得られた水酸化カルシウム圧粉体を、炭酸ガス濃度5%、相対湿度100%、温度30℃の炭酸インキュベータ内に静置、24時間炭酸化を行った。得られた部分炭酸カルシウムブロックを、80℃の1mol/Lの炭酸水素ナトリウム水溶液に浸漬し、48時間経過後、水洗、乾燥を行った。得られた炭酸カルシウムブロックを分割し、露出させた中心部にフェノールフタレイン溶液を滴下したところ、炭酸カルシウムの白色のままで呈色は見られなかった。これにより未反応の水酸化カルシウムの残留のないことが確認された。 <Example 1>
10 g of calcium hydroxide from the Japanese Pharmacopoeia was uniaxially pressed using a circular mold having a diameter of 30 mm at an axial pressure of 50 kg / cm 2 to form a calcium hydroxide compact. The obtained calcium hydroxide compact was left standing in a carbonic acid incubator having a carbon dioxide gas concentration of 5%, a relative humidity of 100%, and a temperature of 30 ° C., and carbonized for 24 hours. The obtained partial calcium carbonate block was immersed in a 1 mol / L sodium hydrogen carbonate aqueous solution at 80 ° C., and after 48 hours, washed with water and dried. When the obtained calcium carbonate block was divided and a phenolphthalein solution was added dropwise to the exposed center portion, the white color of the calcium carbonate remained and no coloration was observed. This confirmed that no unreacted calcium hydroxide remained.
日本薬局方の水酸化カルシウム5g及び、平均粒径300μmの日本薬局方の塩化ナトリウム5gをV型混合器を用いて均一に混合した。得られた混合紛を、100kg/cm2の軸圧で直径30mmの円形金型を用いて、一軸加圧成形し、水酸化カルシウム/塩化ナトリウム圧粉体を成形した。得られた水酸化カルシウム/塩化ナトリウム圧粉体を、炭酸ガス濃度20%、相対湿度100%、温度30℃の炭酸インキュベータ内に静置、24時間炭酸化を行った。得られた部分炭酸カルシウム/塩化ナトリウムブロックを、蒸留水で5回置換洗浄し、塩化ナトリウムを除去した。得られた多孔質部分炭酸カルシウムブロックを、100℃の0.5mol/Lの炭酸アンモニウム水溶液に浸漬し、48時間経過後、水洗、乾燥を行った。得られた多孔質炭酸カルシウムブロックを分割し、露出させた中心部にフェノールフタレイン溶液を滴下したところ、炭酸カルシウムの白色のままで呈色は見られなかった。これにより未反応の水酸化カルシウムの残留のないことが確認された。 <Example 2>
5 g of Japanese Pharmacopoeia calcium hydroxide and 5 g of Japanese Pharmacopoeia sodium chloride with an average particle size of 300 μm were uniformly mixed using a V-type mixer. The obtained mixed powder was uniaxially pressed using a circular mold having a diameter of 30 mm at an axial pressure of 100 kg / cm 2 to form a calcium hydroxide / sodium chloride green compact. The obtained calcium hydroxide / sodium chloride compact was allowed to stand in a carbonic acid incubator having a carbon dioxide concentration of 20%, a relative humidity of 100%, and a temperature of 30 ° C., and carbonized for 24 hours. The obtained partial calcium carbonate / sodium chloride block was substituted and washed five times with distilled water to remove sodium chloride. The obtained porous partial calcium carbonate block was immersed in a 0.5 mol / L ammonium carbonate aqueous solution at 100 ° C., and after 48 hours, washed with water and dried. When the obtained porous calcium carbonate block was divided and a phenolphthalein solution was added dropwise to the exposed center, no coloration was observed with the white color of calcium carbonate. This confirmed that no unreacted calcium hydroxide remained.
実施例1と同様の条件で、水酸化カルシウム圧粉体を成形した後、炭酸インキュベータにより炭酸化を行い、部分炭酸カルシウムブロックを得たが、その後の炭酸水素ナトリウム水溶液への浸漬は行わなかった。得られた部分炭酸化カルシウムブロックを分割し、露出させた中心部にフェノールフタレイン溶液を滴下したところ、中心部より外側は白色のままで呈色はみられなかったが、中心部は赤色に呈色した。これにより、未反応の水酸化カルシウムが残留していることが確認された。 <Comparative Example 1>
After molding a calcium hydroxide compact under the same conditions as in Example 1, carbonization was performed with a carbonic acid incubator to obtain a partial calcium carbonate block, but subsequent immersion in an aqueous sodium bicarbonate solution was not performed. . When the obtained partially carbonated block was divided and a phenolphthalein solution was dropped onto the exposed center part, the outside of the center part remained white and no color was seen, but the center part was red. Colored. This confirmed that unreacted calcium hydroxide remained.
Claims (2)
- (a)水酸化カルシウムブロック成形工程
(b)二酸化炭素接触工程
(c)炭酸イオン含有水溶液浸漬工程
を含む炭酸カルシウムブロックの製造方法。 (A) Calcium hydroxide block forming step (b) Carbon dioxide contact step (c) A method for producing a calcium carbonate block including a carbonate ion-containing aqueous solution immersion step. - さらに、
(d)孔形成物質混合工程
(e)孔形成工程
を含む請求項1に記載の炭酸カルシウムブロックの製造方法。 further,
The manufacturing method of the calcium carbonate block of Claim 1 including the (d) pore formation substance mixing process (e) pore formation process.
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AU2015325497A AU2015325497B2 (en) | 2014-09-30 | 2015-09-29 | Method for manufacturing calcium carbonate blocks |
CN201580032147.1A CN106458626B (en) | 2014-09-30 | 2015-09-29 | The manufacturing method of calcium carbonate lump |
US15/515,470 US10392259B2 (en) | 2014-09-30 | 2015-09-29 | Method for manufacturing calcium carbonate block |
EP15847820.6A EP3202714B1 (en) | 2014-09-30 | 2015-09-29 | Method for producing calcium carbonate blocks |
JP2016552061A JP6259926B2 (en) | 2014-09-30 | 2015-09-29 | Method for producing calcium carbonate block |
ES15847820T ES2816635T3 (en) | 2014-09-30 | 2015-09-29 | Method for producing calcium carbonate blocks |
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---|---|---|---|---|
WO2017038360A1 (en) * | 2015-08-31 | 2017-03-09 | 株式会社ジーシー | Method for producing porous body including calcium carbonate and method for producing porous body including carbonated apatite |
WO2018173915A1 (en) | 2017-03-21 | 2018-09-27 | 国立大学法人九州大学 | Method for producing calcium carbonate block |
JPWO2018074429A1 (en) * | 2016-10-17 | 2019-08-08 | 国立大学法人九州大学 | Medical honeycomb structure |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50149599A (en) * | 1974-05-23 | 1975-11-29 | ||
JPS5935024A (en) * | 1982-08-17 | 1984-02-25 | Okutama Kogyo Kk | Granular material of water dispersible synthetic calcium carbonate |
JPS63104647A (en) * | 1986-10-21 | 1988-05-10 | Akimoto Todaka | Porous adsorbent of synthetic calcium carbonate |
JPH08198659A (en) * | 1995-01-19 | 1996-08-06 | Koji Mitsuo | Hardened material |
JP2015066087A (en) * | 2013-09-27 | 2015-04-13 | 株式会社ジーシー | Manufacturing method of carbonate apatite molding, and carbonate apatite molding manufactured by the method |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2746708B2 (en) * | 1989-12-19 | 1998-05-06 | 恒和化学工業株式会社 | Composition for paint with excellent concealing properties |
JPH05237178A (en) | 1991-04-08 | 1993-09-17 | Olympus Optical Co Ltd | Bone supplement material and production thereof |
JP3656129B2 (en) | 1995-04-20 | 2005-06-08 | 秀明 高橋 | Method for producing solidified calcium carbonate, raw material powder for production, and method for producing raw material powder |
EP1607373A4 (en) * | 2003-02-27 | 2011-10-26 | Okutama Kogyo Co Ltd | Spherical calcium carbonate and method for production thereof |
WO2004112856A1 (en) | 2003-06-24 | 2004-12-29 | Kyushu Tlo Company Limited | Medical bone prosthetic material and process for producing the same |
JP4539121B2 (en) | 2004-02-27 | 2010-09-08 | Jfeスチール株式会社 | Method for producing carbonated solid |
BRPI0601717A (en) | 2006-05-04 | 2007-12-18 | Du Pont Brasil | process for the manufacture of calcium carbonate |
CN101792166A (en) * | 2009-07-17 | 2010-08-04 | 王嘉兴 | Method for producing blocky sodium hydroxide and calcium carbonate by using carbide slag |
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- 2015-09-29 US US15/515,470 patent/US10392259B2/en active Active
- 2015-09-29 EP EP15847820.6A patent/EP3202714B1/en active Active
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50149599A (en) * | 1974-05-23 | 1975-11-29 | ||
JPS5935024A (en) * | 1982-08-17 | 1984-02-25 | Okutama Kogyo Kk | Granular material of water dispersible synthetic calcium carbonate |
JPS63104647A (en) * | 1986-10-21 | 1988-05-10 | Akimoto Todaka | Porous adsorbent of synthetic calcium carbonate |
JPH08198659A (en) * | 1995-01-19 | 1996-08-06 | Koji Mitsuo | Hardened material |
JP2015066087A (en) * | 2013-09-27 | 2015-04-13 | 株式会社ジーシー | Manufacturing method of carbonate apatite molding, and carbonate apatite molding manufactured by the method |
Non-Patent Citations (3)
Title |
---|
See also references of EP3202714A4 * |
SHIGEKI MATSUYA ET AL.: "Preparation of carbonated apatite monolith by treatment of calcium carbonate in phosphate solutions", THE JOURNAL OF THE JAPANESE SOCIETY FOR DENTAL MATERIALS AND DEVICES, vol. 22, no. 5, 25 August 2003 (2003-08-25), pages 406, XP009501549 * |
TETSURO OIKE ET AL.: "Phenomenological Analysis on Strength Development of Casting Calcium Carbonate", JOURNAL OF THE SOCIETY OF INORGANIC MATERIALS, vol. 18, no. 352, 1 May 2011 (2011-05-01), Japan, pages 123 - 127, XP009501551 * |
Cited By (9)
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WO2017038360A1 (en) * | 2015-08-31 | 2017-03-09 | 株式会社ジーシー | Method for producing porous body including calcium carbonate and method for producing porous body including carbonated apatite |
JPWO2018074429A1 (en) * | 2016-10-17 | 2019-08-08 | 国立大学法人九州大学 | Medical honeycomb structure |
JP2022050587A (en) * | 2016-10-17 | 2022-03-30 | 国立大学法人九州大学 | Medical honeycomb structure |
JP7089284B2 (en) | 2016-10-17 | 2022-06-22 | 国立大学法人九州大学 | Honeycomb structure for medical use |
JP7510702B2 (en) | 2016-10-17 | 2024-07-04 | 国立大学法人九州大学 | Medical honeycomb structure |
WO2018173915A1 (en) | 2017-03-21 | 2018-09-27 | 国立大学法人九州大学 | Method for producing calcium carbonate block |
JPWO2018173915A1 (en) * | 2017-03-21 | 2020-01-30 | 国立大学法人九州大学 | Method for producing calcium carbonate block |
US11167060B2 (en) | 2017-03-21 | 2021-11-09 | Kyushu University, National University Corporation | Method for producing calcium carbonate block |
JP7108317B2 (en) | 2017-03-21 | 2022-07-28 | 国立大学法人九州大学 | Manufacturing method of calcium carbonate block |
Also Published As
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CN106458626A (en) | 2017-02-22 |
AU2015325497A1 (en) | 2017-04-20 |
EP3202714A1 (en) | 2017-08-09 |
JP6259926B2 (en) | 2018-01-10 |
EP3202714B1 (en) | 2020-07-08 |
AU2015325497B2 (en) | 2018-03-15 |
CN106458626B (en) | 2019-04-09 |
US10392259B2 (en) | 2019-08-27 |
ES2816635T3 (en) | 2021-04-05 |
EP3202714A4 (en) | 2018-05-23 |
JPWO2016052502A1 (en) | 2017-04-27 |
US20170210635A1 (en) | 2017-07-27 |
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