CN105214137A - Bone renovating material and preparation method thereof - Google Patents
Bone renovating material and preparation method thereof Download PDFInfo
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- CN105214137A CN105214137A CN201510638536.0A CN201510638536A CN105214137A CN 105214137 A CN105214137 A CN 105214137A CN 201510638536 A CN201510638536 A CN 201510638536A CN 105214137 A CN105214137 A CN 105214137A
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Abstract
The invention discloses a kind of bone renovating material and preparation method thereof, bone renovating material comprises the raw material of following parts by weight: titanium oxide 40 ~ 50 parts, zirconium dioxide 10 ~ 20 parts, aluminium oxide 40 ~ 60 parts, fluor-apatite 70 ~ 80 parts, calcium polyphosphate 10 ~ 50 parts, hydroxyl magnesium silicate 40 ~ 90 parts, dispersant 20 ~ 100 parts, polyethylene 100 ~ 200 parts.Its preparation method is: titanium oxide, zirconium dioxide, aluminium oxide, fluor-apatite, calcium polyphosphate, hydroxyl magnesium silicate, dispersant is even, be warming up to 800 ~ 1000 DEG C of sintering 2 ~ 3h, material after sintering is immersed polyethylene solution, soaks 1 ~ 2 hour, take out; Lyophilization.Gained bone renovating material of the present invention, after poly immersion, can significantly improve porosity, reduces hardening time, accelerates solidification process, and therefore, bone renovating material of the present invention has more suitable porosity, aperture and hardening time.
Description
Technical field
The present invention relates to a kind of bone renovating material and preparation method thereof.
Background technology
Bone is combined by organic and inorganic salt and is formed.Organic substance is osseocolla albumen mainly, makes bone have certain toughness.Inorganic salt and hard mineral (hydroxylapatite crystal, the i.e. complex of calcium phosphate and calcium hydroxide) make bone hard unyielding, stand proudly, be the factor affecting bone hardness.Organic principle and inorganic two kinds of compositions have constant ratio, and generally speaking, the former accounts for 34% of adult bone dry weight, and the latter accounts for 65%, and both combinations make bone have very large toughness and robustness.
At field of orthopaedics, the Cranial defect caused by the many reasons such as severe trauma, bone tumor, osteomyelitis is very common.Bone renovating material conventional at present comprises autologous bone and metal prostheses.Autologous bone adds wound and the misery of patient; The problems such as metal prostheses existence loosens, fracture.Therefore, artificial bone substitute materials skin grafing and mending Cranial defect becomes medical science emphasis.Artificial bone refers to the bioartificial materials that can substitute human bone or repair osseous tissue defect.When replacing joint or the fracture for the treatment of bone, optimal mode realizes self repairing of bone by function of tissue regeneration.Such as, but in most cases, human bone can not realize self and repair, and bone necrosis, Bone and joint trauma, at this moment just needs the help of artificial bone, and the development of desirable artificial bone is an important topic of medical science and biomaterial scientific domain.
CN201010121598.1 discloses a kind of bone renovating material mixing strontium, and this bone renovating material is based on biological bone, and obtain the bone renovating material mixing strontium element after process, the molar concentration that the relative calcium of strontium mixes is 0.1-10%.Its preparation method is immersed in by biological bone material containing in strontium solution, make to have the physical and chemical effect promoting the gentlenesses such as the strontium element of osteogenic activity is adsorbed by solution and the Dynamic ion of storeroom, ion exchange, in slow infiltration mineral content, thus form the bone renovating material mixing strontium.But this bone renovating material infiltrates slow, and porosity is low.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, provide a kind of bone renovating material and preparation method thereof, porosity is high, quick solidifying.
The present invention is by the following technical solutions:
Bone renovating material, comprises the raw material of following parts by weight: titanium oxide 40 ~ 50 parts, zirconium dioxide 10 ~ 20 parts, aluminium oxide 40 ~ 60 parts, fluor-apatite 70 ~ 80 parts, calcium polyphosphate 10 ~ 50 parts, hydroxyl magnesium silicate 40 ~ 90 parts, dispersant 20 ~ 100 parts, polyethylene 100 ~ 200 parts.
As preferably, bone renovating material, comprises the raw material of following parts by weight: titanium oxide 45 parts, zirconium dioxide 15 parts, aluminium oxide 50 parts, fluor-apatite 75 parts, calcium polyphosphate 30 parts, hydroxyl magnesium silicate 60 parts, dispersant 50 parts, polyethylene 150 parts.
As preferably, the particle diameter of aluminium oxide is 40 ~ 50nm.
As preferably, dispersant is brium carbonate or magnesium phosphate.
The preparation method of above-mentioned bone renovating material, comprise the following steps: titanium oxide, zirconium dioxide, aluminium oxide, fluor-apatite, calcium polyphosphate, hydroxyl magnesium silicate, dispersant is even, be warming up to 800 ~ 1000 DEG C of sintering 2 ~ 3h, material after sintering is immersed polyethylene solution, soak 1 ~ 2 hour, take out; Lyophilization.
beneficial effect
The present invention, after poly immersion, can significantly improve porosity, reduces hardening time, accelerates solidification process, and therefore, bone renovating material of the present invention has more suitable porosity, aperture and and hardening time.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described in detail.
embodiment 1
Bone renovating material, comprises the raw material of following parts by weight: titanium oxide 45 parts, zirconium dioxide 15 parts, aluminium oxide 50 parts, fluor-apatite 75 parts, calcium polyphosphate 30 parts, hydroxyl magnesium silicate 60 parts, dispersant 50 parts, polyethylene 150 parts.
The particle diameter of aluminium oxide is 40 ~ 50nm.
Dispersant is brium carbonate or magnesium phosphate.
The preparation method of above-mentioned bone renovating material, comprise the following steps: titanium oxide, zirconium dioxide, aluminium oxide, fluor-apatite, calcium polyphosphate, hydroxyl magnesium silicate, dispersant is even, be warming up to 900 DEG C of sintering 2.5h, material after sintering is immersed polyethylene solution, soak 1.5 hours, take out; Lyophilization.
embodiment 2
Bone renovating material, comprises the raw material of following parts by weight: titanium oxide 40 parts, zirconium dioxide 10 parts, aluminium oxide 40 parts, fluor-apatite 70 parts, calcium polyphosphate 10 parts, hydroxyl magnesium silicate 40 parts, dispersant 20 parts, polyethylene 100 parts.
The particle diameter of aluminium oxide is 40nm.
Dispersant is brium carbonate or magnesium phosphate.
The preparation method of above-mentioned bone renovating material, comprise the following steps: by titanium oxide, zirconium dioxide, aluminium oxide, fluor-apatite, calcium polyphosphate, hydroxyl magnesium silicate, dispersant evenly, be warming up to 800 DEG C of sintering 2h, the material after sintering is immersed polyethylene solution, soak 1 hour, take out; Lyophilization.
embodiment 3
Bone renovating material, comprises the raw material of following parts by weight: titanium oxide 50 parts, zirconium dioxide 20 parts, aluminium oxide 60 parts, fluor-apatite 80 parts, calcium polyphosphate 50 parts, hydroxyl magnesium silicate 90 parts, dispersant 100 parts, polyethylene 200 parts.
The particle diameter of aluminium oxide is 50nm.
Dispersant is brium carbonate or magnesium phosphate.
The preparation method of above-mentioned bone renovating material, comprise the following steps: by titanium oxide, zirconium dioxide, aluminium oxide, fluor-apatite, calcium polyphosphate, hydroxyl magnesium silicate, dispersant evenly, be warming up to 1000 DEG C of sintering 3h, the material after sintering is immersed polyethylene solution, soak 2 hours, take out; Lyophilization.
comparative example 1
Identical with embodiment 1, difference is: do not add polyethylene.
performance test
The product of Example 1 ~ 4 and comparative example 1, adopts three-point bending resistance method and one-sided open beam method to test bending strength and fracture toughness respectively, the results are shown in Table 1.
Table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Comparative example 1 | |
| Porosity % | 47 | 46 | 45 | 46 | 19 |
| Aperture nm | 100 | 98 | 97 | 96 | 60 |
| Hardening time min | 3 | 3 | 2 | 3 | 24 |
From the above results, the repair materials obtained through poly immersion postlyophilization significantly increases porosity, reduces hardening time, accelerates solidification process.Bone renovating material of the present invention has more suitable porosity, aperture and and hardening time.
Claims (5)
1. bone renovating material, it is characterized in that, comprise the raw material of following parts by weight: titanium oxide 40 ~ 50 parts, zirconium dioxide 10 ~ 20 parts, aluminium oxide 40 ~ 60 parts, fluor-apatite 70 ~ 80 parts, calcium polyphosphate 10 ~ 50 parts, hydroxyl magnesium silicate 40 ~ 90 parts, dispersant 20 ~ 100 parts, polyethylene 100 ~ 200 parts.
2. bone renovating material according to claim 1, it is characterized in that, comprise the raw material of following parts by weight: titanium oxide 45 parts, zirconium dioxide 15 parts, aluminium oxide 50 parts, fluor-apatite 75 parts, calcium polyphosphate 30 parts, hydroxyl magnesium silicate 60 parts, dispersant 50 parts, polyethylene 150 parts.
3. bone renovating material according to claim 1, is characterized in that, the particle diameter of aluminium oxide is 40 ~ 50nm.
4. bone renovating material according to claim 1, is characterized in that, dispersant is brium carbonate or magnesium phosphate.
5. based on the preparation method of bone renovating material according to claim 1, it is characterized in that, comprise the following steps: titanium oxide, zirconium dioxide, aluminium oxide, fluor-apatite, calcium polyphosphate, hydroxyl magnesium silicate, dispersant is even, be warming up to 800 ~ 1000 DEG C of sintering 2 ~ 3h, material after sintering is immersed polyethylene solution, soak 1 ~ 2 hour, take out; Lyophilization.
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| CN201510638536.0A CN105214137B (en) | 2015-09-30 | 2015-09-30 | Bone renovating material and preparation method thereof |
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| CN105214137A true CN105214137A (en) | 2016-01-06 |
| CN105214137B CN105214137B (en) | 2018-12-07 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110237299A (en) * | 2019-06-25 | 2019-09-17 | 太仓新亚逊生物科技有限公司 | Degradation-type bone renovating material |
| CN111529754A (en) * | 2020-05-08 | 2020-08-14 | 重庆大学 | Titanium-based active bone implant with composite coating and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198289A (en) * | 2010-03-24 | 2011-09-28 | 国家纳米技术与工程研究院 | Method for preparing fluorapatite crystal whisker in-situ reinforced porous tricalcium phosphate biological ceramics |
| CN102648008A (en) * | 2009-07-24 | 2012-08-22 | 华沙整形外科股份有限公司 | Porous composite implant based on ceramic and polymeric filler material |
| WO2014146831A1 (en) * | 2013-03-21 | 2014-09-25 | Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der BAM, Bundesanstalt für Materialforschung und -prüfung | Sinterable and/or fusible ceramic mass, production and use thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102648008A (en) * | 2009-07-24 | 2012-08-22 | 华沙整形外科股份有限公司 | Porous composite implant based on ceramic and polymeric filler material |
| CN102198289A (en) * | 2010-03-24 | 2011-09-28 | 国家纳米技术与工程研究院 | Method for preparing fluorapatite crystal whisker in-situ reinforced porous tricalcium phosphate biological ceramics |
| WO2014146831A1 (en) * | 2013-03-21 | 2014-09-25 | Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der BAM, Bundesanstalt für Materialforschung und -prüfung | Sinterable and/or fusible ceramic mass, production and use thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110237299A (en) * | 2019-06-25 | 2019-09-17 | 太仓新亚逊生物科技有限公司 | Degradation-type bone renovating material |
| CN111529754A (en) * | 2020-05-08 | 2020-08-14 | 重庆大学 | Titanium-based active bone implant with composite coating and preparation method thereof |
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| CN105214137B (en) | 2018-12-07 |
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Inventor after: Wang Biao Inventor after: Hao Dingjun Inventor after: Guo Hua Inventor after: Kong Lingbo Inventor after: Gao Wenjie Inventor after: Jin Zhongen Inventor after: Quan Chunlan Inventor after: Zhang Fan Inventor before: Jin Zhongen Inventor before: Quan Chunlan Inventor before: Zhang Fan |
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Effective date of registration: 20181025 Address after: 710000 Nanguo Road No. 76, Beilin gate, Beilin District, Xi'an, Shaanxi Applicant after: XI'AN HONGHUI HOSPITAL Address before: No. 10, Longshan Road, Suzhou high tech Zone, Jiangsu Province Applicant before: Suzhou Koumei New Material Co., Ltd. |
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