CN105213768A - A kind of Chinese medicine composition is for the preparation of the purposes in treatment medicine for treating diabetic nephropathy - Google Patents
A kind of Chinese medicine composition is for the preparation of the purposes in treatment medicine for treating diabetic nephropathy Download PDFInfo
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Abstract
The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine composition for the preparation of the purposes in treatment medicine for treating diabetic nephropathy.Described Chinese medicine composition comprises the raw materials of following parts by weight: Herba Cistanches 6-20 part, Radix Ophiopogonis 6-20 part, Radix Astragali 6-20 part, Radix Salviae Miltiorrhizae 9-15 part, Radix Angelicae Sinensis 6-12 part, Flos Carthami 6-12 part, Fructus Corni 6-12 part, Fructus Arctii 6-15 part, Fructus Lycii 6-12 part, Cortex Cinnamomi 1-5 part and Radix Glycyrrhizae 1-15 part.The reasonable recipe of the Chinese medicine composition that the present invention relates to, synergism is strong, diabetic nephropathy is had to the effect of highly significant.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the preparation of the purposes in treatment medicine for treating diabetic nephropathy.
Background technology
Diabetic nephropathy is the maximum a kind of chronic complicating diseases of serious and hazardness that diabetes cause, it is one of diabetes generalized capillary pathological changes performance, Clinical symptoms is albuminuria, gradual renal function injury, hypertension,, there is severe renal nonfunction late period in edema, is one of major causes of death of diabetics.
Current western medical treatment is many sets about from aspects such as strengthening glycemic control, blood pressure lowering, adjustment lipid metabolism, or adopts the treatment meanss such as dialysis, renal transplantation, although effectively, brings heavy financial burden to patient.Chinese traditional treatment has rich experience, successful, no dependence, and overall dialectical, individuality treats, and human internal organ is in harmonious proportion, equilibrium between yin and yang, recovers benign cycle, obtains good therapeutic effect.Chinese traditional treatment also has safety high in addition, and side effect is little, not easily the advantage such as recurrence.
Chinese patent application 201210311984.6 discloses a kind of Chinese medicine composition being used for the treatment of diabetic nephropathy, and this Chinese medicine composition is obtained by following raw material: the Radix Astragali, dried lily bulb, Semen Persicae, Hirudo, Radix Et Rhizoma Rhei, Rhizoma Alismatis, Fructus Rosae Laevigatae, Semen Euryales, Radix Achyranthis Bidentatae, the Cortex Eucommiae.This Chinese medicine composition has supplementing QI and nourishing YIN, clearing heat and expelling damp, effect of promoting blood circulation to remove obstruction in the collateral, but this Chinese medicine composition is at blood sugar lowering, and kidney and spleen invigorating aspect effect is not very remarkable.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the preparation of the purposes in treatment medicine for treating diabetic nephropathy, this Chinese medicine composition has blood sugar lowering, protects effect that kidney protects kidney and benefiting QI for activating blood circulation, also there is good effect, the advantages such as side effect is low, taking convenience.In addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the preparation of the purposes in treatment medicine for treating diabetic nephropathy.
Described Chinese medicine composition comprises the raw materials of following parts by weight: Herba Cistanches 6-20 part, Radix Ophiopogonis 6-20 part, Radix Astragali 6-20 part, Radix Salviae Miltiorrhizae 9-15 part, Radix Angelicae Sinensis 6-12 part, Flos Carthami 6-12 part, Fructus Corni 6-12 part, Fructus Arctii 6-15 part, Fructus Lycii 6-12 part, Cortex Cinnamomi 1-5 part and Radix Glycyrrhizae 1-15 part.
Preferably, described Chinese medicine composition comprises the raw materials of following parts by weight: Herba Cistanches 8 parts, Radix Ophiopogonis 10 parts, the Radix Astragali 6 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Angelicae Sinensis 10 parts, 6 parts, Flos Carthami, Fructus Corni 10 parts, Fructus Arctii 8 parts, Fructus Lycii 12 parts, Cortex Cinnamomi 3 parts and 10 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition comprises the raw materials of following parts by weight: Herba Cistanches 20 parts, Radix Ophiopogonis 20 parts, the Radix Astragali 16 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Angelicae Sinensis 6 parts, 12 parts, Flos Carthami, Fructus Corni 6 parts, Fructus Arctii 15 parts, Fructus Lycii 8 parts, Cortex Cinnamomi 4 parts and 15 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition comprises the raw materials of following parts by weight: Herba Cistanches 12 parts, Radix Ophiopogonis 15 parts, the Radix Astragali 10 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Angelicae Sinensis 12 parts, 10 parts, Flos Carthami, Fructus Corni 8 parts, Fructus Arctii 6 parts, Fructus Lycii 10 parts, Cortex Cinnamomi 2 parts and 5 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is made into capsule, tablet, powder, granule or pill.
Accordingly, the preparation method of described Chinese medicine composition comprises following step:
A) Radix Ophiopogonis is taken, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 30-45% is the alcoholic solution of 60-85%, and regulation and control carbon dioxide flow is 15-20L/h, and extracting pressure is 15-20MPa, extraction temperature is 40-60 DEG C, extraction time is 1.5-2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
B) take Herba Cistanches, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Flos Carthami, Fructus Corni, Fructus Arctii, Fructus Lycii, Cortex Cinnamomi and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, add 3-8 times amount water soaking after 1-3 hour, boil 30-60 minute, filter, obtain filtrate, 2-5 times of water gaging is added in filtering residue, boil 15-30 minute, then use slow fire boiling 1-2 hour, filter, obtain filtrate, merge twice filtrate;
C) described Radix Ophiopogonis extract and described twice filtrate are mixed, be concentrated into the thick paste that relative density is 1.20-1.35, drying under reduced pressure, cross 100-200 mesh sieve after pulverizing, obtain Chinese medicine composition.
Source, the nature and flavor of the present invention's component used, return through and effect:
Herba Cistanches: be the fleshy stem of the dry zone scale leaf of orobanchaceae plant cistanche; Sweet in the mouth, salty, warm in nature; Return kidney, large intestine channel; Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.
Radix Ophiopogonis: be the tuber of liliaceous plant Radix Ophiopogonis, Hubei Radix Ophiopogonis, short Roripa mountain wheat or Radix Liriopes, dwarf lilyturf etc.; Sweet, micro-hardship, is slightly cold, GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and for dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Radix Ophiopogonis is containing cupreol, aminoacid, volume glucose and glycoside.Can immunologic function be improved, have inhibitory action to various bacteria, pituitary adrenal system function can be strengthened, improve organism adaptation ability, have arrhythmia and the peripheral vascular effect of expansion, can hypoxia-bearing capability be improved, have hypoglycemic activity.
The Radix Astragali: be the root of the leguminous plant Radix Astragali; Sweet in the mouth, tepor; Return lung, spleen, liver, kidney channel; Invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of labiate Radix Salviae Miltiorrhizae; Bitter in the mouth, cold nature; GUIXIN, Liver Channel; Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica; Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Flos Carthami: belong to feverfew, has the effect of good promoting blood circulation to restore menstrual flow network, eliminating stasis to stop pain, and the traditional Chinese medical science thinks that Flos Carthami nature and flavor are gentle, has a lot of benefit to myocardial ischemia, also has a function can expand expansion body hat tremulous pulse and femoral artery exactly.The spasm of vascular smooth muscle can also be removed and strengthen hypoxia-bearing capability, stoping further developing of thrombosis, reduce again the effect of cholesterol.Can also improve the circulatory disturbance of heart and brain tissues, the treatment for coronary heart disease and cerebral thrombosis is beneficial to.
Fructus Corni: be the drying and ripening sarcocarp of Cornaceae plant Fructus Corni; Sour in the mouth, puckery, slightly warm in nature; Return liver, kidney channel; Liver and kidney tonifying, essence astringing and desertion stemming.
Fructus Arctii: acrid in the mouth, warm in nature; Expelling wind and cold pain relieving.
Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum; Sweet in the mouth, property is put down; Return liver, kidney channel; Nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Cortex Cinnamomi: be the dry bark of canella Cortex Cinnamomi; Acrid in the mouth, sweet, extremely hot in nature; Return kidney, spleen, the heart, Liver Channel; Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
Radix Glycyrrhizae: be the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, the present invention has following beneficial effect:
1, Chinese medicine composition of the present invention have employed the medical materials such as Radix Ophiopogonis, Herba Cistanches and the Radix Astragali, by the synergism of each composition activity composition, achieves the good therapeutic effect to diabetic nephropathy;
2, compared with the chemicals of Current therapeutic diabetic nephropathy, described Chinese medicine composition is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and described Chinese medicine composition effect is comprehensive, medication effect is better, significantly improve the compliance of diabetics, and improve the quality of life of patient.
3, Chinese medicine composition of the present invention has and protects kidney and protect the effect that kidney and spleen invigorating invigorate blood circulation, and also has good effect, the advantages such as cost is low, and obvious effective rate is high, taking convenience.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1
The pharmaceutical composition that the present invention relates to comprises the raw materials of following parts by weight: Herba Cistanches 8 parts, Radix Ophiopogonis 10 parts, the Radix Astragali 6 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Angelicae Sinensis 10 parts, 6 parts, Flos Carthami, Fructus Corni 10 parts, Fructus Arctii 8 parts, Fructus Lycii 12 parts, Cortex Cinnamomi 3 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is as follows: take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 45% is the alcoholic solution of 75%, and regulation and control carbon dioxide flow is 20L/h, and extracting pressure is 15MPa, extraction temperature is 60 DEG C, extraction time is 2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis; Take Herba Cistanches, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Flos Carthami, Fructus Corni, Fructus Arctii, Fructus Lycii, Cortex Cinnamomi and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, add 4 times amount water soakings after 2 hours, boil 60 minutes, filter, obtain filtrate, 5 times of water gagings are added in filtering residue, boil 30 minutes, then use slow fire boiling 2 hours, filter, obtain filtrate, merge twice filtrate; Described Radix Ophiopogonis extract and described twice filtrate are mixed, is concentrated into the thick paste that relative density is 1.25, drying under reduced pressure, cross 100 mesh sieves after pulverizing, obtain Chinese medicine composition, add capsule and commonly use adjuvant, incapsulate in shell, obtain Chinese medicinal composition capsules agent.
embodiment 2
The pharmaceutical composition that the present invention relates to comprises the raw materials of following parts by weight: Herba Cistanches 20 parts, Radix Ophiopogonis 20 parts, the Radix Astragali 16 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Angelicae Sinensis 6 parts, 12 parts, Flos Carthami, Fructus Corni 6 parts, Fructus Arctii 15 parts, Fructus Lycii 8 parts, Cortex Cinnamomi 4 parts and 15 parts, Radix Glycyrrhizae.
Take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 30% is the alcoholic solution of 75%, and regulation and control carbon dioxide flow is 15L/h, and extracting pressure is 20MPa, extraction temperature is 50 DEG C, extraction time is 2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis; Take Herba Cistanches, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Flos Carthami, Fructus Corni, Fructus Arctii, Fructus Lycii, Cortex Cinnamomi and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, add 8 times amount water soakings after 2 hours, boil 60 minutes, filter, obtain filtrate, 3 times of water gagings are added in filtering residue, boil 30 minutes, then use slow fire boiling 2 hours, filter, obtain filtrate, merge twice filtrate; Described Radix Ophiopogonis extract and described twice filtrate are mixed, is concentrated into the thick paste that relative density is 1.30, drying under reduced pressure, cross 200 mesh sieves after pulverizing, obtain Chinese medicine composition, add capsule and commonly use adjuvant, incapsulate in shell, obtain Chinese medicinal composition capsules agent.
embodiment 3
The pharmaceutical composition that the present invention relates to comprises the raw materials of following parts by weight: Herba Cistanches 12 parts, Radix Ophiopogonis 15 parts, the Radix Astragali 10 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Angelicae Sinensis 12 parts, 10 parts, Flos Carthami, Fructus Corni 8 parts, Fructus Arctii 6 parts, Fructus Lycii 10 parts, Cortex Cinnamomi 2 parts and 5 parts, Radix Glycyrrhizae.
Preparation method is similar to Example 1.
the Chinese medicine composition that the present invention relates to is to the therapeutical effect of Diabetic nephropathy animal model
1, model is prepared
Select healthy male adult SD rats 50, body weight 0.35kg-0.4kg, feed with high lipid food, do not limit and take the photograph water.Abdominal cavity is injected with streptozotocin after rat is carried out one-sided kidney ligation operation.Operation consent Rat Fast 12h, injection Nembutal sodium solution is anaesthetized, after confirming anesthesia, by rat along kidney base of a fruit ligation kidney arteriovenous and ureter.When postoperative 2 weeks, each group Rat Fast 18h, then disposable celiac injects 1% streptozotocin solution 0.55g/kg, and concrete administration volume is 5.5ml/kg, and after injection, rat freely ingests water.After modeling completes 72h, survey blood glucose through tail vein blood.Modeling Success criteria: 1. fasting glucose >=16.65mmol/L; 2. glucose in urine strong positive; 3. urine volume is greater than 50% of matched group, i.e. modeling success.
2, experiment grouping and administration
After modeling terminates, 50 rats are divided into 5 groups at random, often organize 10, be respectively model group, pioglitazone group, Chinese medicine A group, Chinese medicine B group and Chinese medicine C group.Each group gives following medicine respectively:
Model group: the isopyknic distilled water of gavage;
Pioglitazone group: gavage pioglitazone 0.25g/kgd;
Chinese medicine A group: Chinese medicinal composition capsules agent 0.3g/kgd prepared by the gavage embodiment of the present invention 1;
Chinese medicine B group: Chinese medicinal composition capsules agent 0.3g/kgd prepared by the gavage embodiment of the present invention 2;
Chinese medicine C group: Chinese medicinal composition capsules agent 0.3g/kgd prepared by the gavage embodiment of the present invention 3;
Above-mentioned each group every day gastric infusion once, continuous 8 weeks, normally raise.Blood sampling measures fasting glucose, glycolated hemoglobin and microdose urine protein.
3, index determining
(1) mensuration of blood glucose: all rats detect fasting glucose respectively at getting tail vein before administration after 8 weeks with administration, the blood sample of taking-up is put into protein precipitant, after room temperature places 7min, centrifugal 5min(3000r/min), get supernatant, use determination of glucose oxidase blood glucose value.
(2) mensuration of glycolated hemoglobin: each group rat after 8 weeks, measures the content of glycolated hemoglobin with administration before administration by immune gel diffusion method.
(3) mensuration of microalbumin in urinating: administration 8 weeks rear rats are put in metabolic cage respectively and raise, collect 12 hours overnight urine, accurate recording urine volume.Get 4ml, after sodium azide process, centrifugal (2000r/min) 10min, gets supernatant and is placed in-20 DEG C of refrigerators and preserves urinaryalbumin to be measured.The albumin standards 400ml getting respective concentration adds in supernatant, adds 200ml0.231mmol/L bromophenol blue developer respectively, and mixing, with ultraviolet spectrophotometer, measures OD value under 600nm wavelength.
4, experimental result and discussion
The Chinese medicine composition that table 1 the present invention relates to is on the impact of diabetic nephropathy rats fasting glucose
Note: compare with model group, * P < 0.05, * * P < 0.01; Compare with pioglitazone group, #P < 0.05.
As shown in Table 1, after the administration of Chinese medicine A, B and C group, the blood glucose value of rat obviously reduces, and compared with model group, has the difference of significance, and wherein, the change of blood sugar value of Chinese medicine C group is maximum; The blood glucose value of Chinese medicine A, B and C group is better than pioglitazone group, and Chinese medicine C group has significant difference (P < 0.05); Visible, the Chinese medicine composition that the present invention relates to significantly can reduce the blood glucose of diabetic nephropathy rats, and the Chinese medicine composition that the present invention relates to can be used for treating diabetic nephropathy.
The Chinese medicine composition that table 2 the present invention relates to is on the impact of diabetic nephropathy rats glycolated hemoglobin
Note: compare with model group, * P < 0.05, * * P < 0.01.
As shown in Table 2, after pioglitazone group, the administration of Chinese medicine A, B and C group, the glycolated hemoglobin of rat obviously reduces, and compared with model group, has the difference (P < 0.01) of significance.The effect of Chinese medicine A, B and C group is better than pioglitazone group, but no difference of science of statistics.Visible, the Chinese medicine composition that the present invention relates to has the effect reducing diabetic nephropathy rats glycolated hemoglobin.
The Chinese medicine composition that table 3 the present invention relates to is on the impact of diabetic nephropathy rats microdose urine protein
Note: compare with model group, * P < 0.05, * * P < 0.01; Compare with pioglitazone group, #P < 0.05, ##P < 0.01.
As shown in Table 3, compared with model group, the microdose urine protein content of pioglitazone group and Chinese medicine A, B, C group all has significant difference (P < 0.01).Visible, Chinese medicine composition of the present invention has good synergism in treatment diabetic nephropathy rats microdose urine protein, its therapeutic effect is better than pioglitazone group, wherein Chinese medicine C group has extremely significant difference (P < 0.01), and this shows that the Chinese medicine composition that the present invention relates to is delaying to have outstanding treatment advantage in diabetic nephropathy PD.
the Chinese medicine composition that the present invention relates to is to the observation of curative effect of diabetic nephropathy clinical patients volunteer
One, diagnostic criteria
Tcm diagnosis standard: have foam in urine, weak, nausea and vomiting, shallow complexion or dark and gloomy, heavy sensation of the body edema, soreness of the waist and knees and abdominal distention, nocturia, forgetful, insomnia, dizziness and tinnitus, feverish sensation in the palms and soles, purplish tongue or light red tongue or ecchymosis, thick fur is greasy, deep-thready pulse or puckery; Dialectically logical to adjust for weakness of the spleen and kidney, lung lose, the water stasis of blood tied mutually, water turbid regardless of.
Two, evaluation of clinical curative effect standard
Effective: clinical symptoms is improved obviously, soreness of the waist and knees, fatigue and weak, dry mouth and throat, nocturia etc. disappear or substantially disappear, blood sugar level fluctuation is within normal range, blood pressure≤128/80mmHg, 24h urine protein < 30mg, blood urea nitrogen and creatinine are all down to normal level;
Effective: clinical symptom relief, soreness of the waist and knees, fatigue and weak, dry mouth and throat, nocturia etc. be improved significantly, fasting glucose controls desirable, and fluctuation of blood pressure is at about 140/90mmHg, 24h urine protein and blood urea nitrogen creatinine all have decline, but do not take a turn for the better completely;
Invalid: clinical symptoms is improved not obvious, blood pressure and blood glucose decline without decline or have but undesirable, and 24h urine protein quantitation and blood urea nitrogen creatinine all do not decline, or decline and do not reach effective standard.
Three, clinical trial
1, physical data
All selected diabetic nephropathy clinical volunteers patients are divided into 4 groups at random, treatment A group 50 example, treatment B group 50 example, treatment C group 50 example, matched group 50 example.Age is 40 years old-60 years old, and the influence factors such as 4 groups of ages, sex, symptoms, through statistical procedures, there was no significant difference, meets a point set condition.
2, Therapeutic Method
Treatment A group: take the capsule that embodiment 1 prepares, every day 3 times, each 4, serve on 1 month;
Treatment B group: take the capsule that embodiment 2 prepares, every day 3 times, each 4, serve on 1 month;
Treatment C group: take the capsule that embodiment 3 prepares, every day 3 times, each 4, serve on 1 month;
Matched group: take TANGMAIKANG KELI (accurate word Z10970026, the 5g*10 bag/box of traditional Chinese medicines), one time 1 bag, 3 times on the one, serve on 1 month.
3, therapeutic outcome, as shown in table 4:
。
This test adopts TANGMAIKANG KELI as a control group, TANGMAIKANG KELI has replenishing YIN and removing heat, blood circulation promoting and blood stasis dispelling, QI invigorating is reinforced the kidney, hypoglycemic effect, can be used for patient such as treatment non-insulin-dependent diabetes mellitus and complication etc., by comparing with the traditional Chinese medicine composition for treating effect that the present invention relates to, embody the curative effect of Chinese medicine composition in the sick nephropathy for the treatment of urine that the present invention relates to, make inventor surprisingly, the obvious effective rate for the treatment of A group, treatment B group and treatment C group is all greater than 75%, and total effective rate is all greater than 85%, is better than obvious effective rate and the total effective rate of matched group.Visible, the pharmaceutical composition good effect that the present invention relates to, obvious effective rate is high, can as the drug use for the treatment of diabetic nephropathy.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (6)
1. Chinese medicine composition is for the preparation of the purposes in treatment medicine for treating diabetic nephropathy, and it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:
Herba Cistanches 6-20 part, Radix Ophiopogonis 6-20 part, Radix Astragali 6-20 part, Radix Salviae Miltiorrhizae 9-15 part, Radix Angelicae Sinensis 6-12 part, Flos Carthami 6-12 part, Fructus Corni 6-12 part, Fructus Arctii 6-15 part, Fructus Lycii 6-12 part, Cortex Cinnamomi 1-5 part and Radix Glycyrrhizae 1-15 part.
2. purposes as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:
Herba Cistanches 8 parts, Radix Ophiopogonis 10 parts, the Radix Astragali 6 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Angelicae Sinensis 10 parts, 6 parts, Flos Carthami, Fructus Corni 10 parts, Fructus Arctii 8 parts, Fructus Lycii 12 parts, Cortex Cinnamomi 3 parts and 10 parts, Radix Glycyrrhizae.
3. purposes as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:
Herba Cistanches 20 parts, Radix Ophiopogonis 20 parts, the Radix Astragali 16 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Angelicae Sinensis 6 parts, 12 parts, Flos Carthami, Fructus Corni 6 parts, Fructus Arctii 15 parts, Fructus Lycii 8 parts, Cortex Cinnamomi 4 parts and 15 parts, Radix Glycyrrhizae.
4. purposes as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:
Herba Cistanches 12 parts, Radix Ophiopogonis 15 parts, the Radix Astragali 10 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Angelicae Sinensis 12 parts, 10 parts, Flos Carthami, Fructus Corni 8 parts, Fructus Arctii 6 parts, Fructus Lycii 10 parts, Cortex Cinnamomi 2 parts and 5 parts, Radix Glycyrrhizae.
5. the purposes as described in as arbitrary in claim 1-4, it is characterized in that, described Chinese medicine composition is made into capsule, tablet, powder, granule or pill.
6. purposes as claimed in claim 1, it is characterized in that, the preparation method of described Chinese medicine composition comprises following step:
A) Radix Ophiopogonis is taken, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 30-45% is the alcoholic solution of 60-85%, and regulation and control carbon dioxide flow is 15-20L/h, and extracting pressure is 15-20MPa, extraction temperature is 40-60 DEG C, extraction time is 1.5-2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
B) take Herba Cistanches, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Flos Carthami, Fructus Corni, Fructus Arctii, Fructus Lycii, Cortex Cinnamomi and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, add 3-8 times amount water soaking after 1-3 hour, boil 30-60 minute, filter, obtain filtrate, 2-5 times of water gaging is added in filtering residue, boil 15-30 minute, then use slow fire boiling 1-2 hour, filter, obtain filtrate, merge twice filtrate;
C) described Radix Ophiopogonis extract and described twice filtrate are mixed, be concentrated into the thick paste that relative density is 1.20-1.35, drying under reduced pressure, cross 100-200 mesh sieve after pulverizing, obtain Chinese medicine composition.
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Citations (1)
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| CN102166297A (en) * | 2010-02-26 | 2011-08-31 | 田向阳 | Chinese medicinal formula for treating diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102166297A (en) * | 2010-02-26 | 2011-08-31 | 田向阳 | Chinese medicinal formula for treating diabetes |
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| 李泽宇 等: "糖尿病肾病危险因素及血压控制临界值研究", 《中国全科医学》 * |
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