CN105213664A - Epstein-Barr virus infects and medicine - Google Patents

Abstract

The present invention relates to epstein-Barr virus to infect and medicine, medicine technology field, in order to solve the difficult and defect of Epstein-Ba Ershi two treatment of viral infections, deficiency of YIN-blood is belonged to by analyzing Epstein-Ba Ershi two viral infection, excessive the wetting of wind is held back, warm knot poison, QI and blood hinders numbness and sends out this disease, with enriching yin and nourishing kidney, removing heat from blood and promoting blood circulation, heat clearing away is drawn out pus by applying a plaster to the affected part, the Chinese medicine combined treatment of dispelling pathogenic wind and eliminating phlegm: Rhizoma Chuanxiong 10 parts, Flos Lonicerae 20 parts, 15 parts, the Radix Rehmanniae, Fructus Forsythiae 15 parts, 15 parts, Folium Mori, Rhizoma Colocasiae antiquori 15 parts, Fructus Gardeniae 15 parts, Radix Achyranthis Bidentatae 15 parts, Radix Isatidis 15 parts, Scolopendra 10 parts, Carapax Trionycis 15 parts, 7 parts, Radix Glycyrrhizae, start with the correct theory scheme of traditional Chinese medical herbal treatment Epstein-Ba Ershi two viral infection, and receive obviously, stable curative effect.

Description

Epstein-Barr virus infects and medicine

Technical field

The present invention relates to epstein-Barr virus to infect and medicine, particularly with the composition of medicine for the treatment of by Chinese herbs, belong to medicine technology field.

Background technology

Epstein-Barr virus infects (Aipositan-Ba'erershibinduganranEpstein-Barrvirusinfectio n, EBVinfection) a kind of herpesvirus--the infection that Epstein-Barr virus causes.Epstein-Barr virus and epstein-Barr virus (Epstein-Barrvirus; EBV) abbreviation, is that M.A. Epsteins in 1963 and Y.M. Ba Er carry out finding when vitro tissue is cultivated to the cell of the burkitt's lymphoma that African children is suffered from, gains the name thus.This virus is a kind of close lymphocyte virus, belongs to herpetoviridae γ group, can infect the bone-marrow-derived lymphocyte of people and primate.Epstein-Barr virus infect, hereinafter referred to as ebv infection ( select from the Internet " Baidupedia ").

Ebv infection is very general, and in the area that socio-economic conditions is poor, the age of population infection Epstein-Barr virus, comparatively early Epstein-Barr virus antibody positive rate was high, without obvious clinical symptoms after infection.Regional preferably in socio-economic conditions, after ebv infection occurs in adolescence, and show as infectious monocytosis more.( select from the Internet " Baidupedia ").

Epstein-Barr virus is propagated by saliva.Several form below ebv infection main manifestations, its clinical manifestation, diagnostic method and treat different.The diagnostic method of Epstein-Barr virus mainly detects the specific antibody of Epstein-Barr virus.Because Epstein-Barr virus has oncogenic potential, its attenuated vaccine or killed vaccine have certain risk.Membrane antigen vaccine just under study for action.( select from the Internet " Baidupedia ").

Child is more common in constitutional inapparent infection.In third world countries, the child within 3 years old about has 90 ~ 100% once to infect by EBV.There is not clinical symptoms after infection, but in serum, have the anti-EBV antibody of specificity.Infect EBV afterwards and can form lasting latent infection in human B lymphocytes and pars oralis pharyngis epithelial cell, not open close saliva excessively excretes, and infects Healthy People.( select from the Internet " Baidupedia ").

The infectious monocytosis that ebv infection shows is more common in teenager and the adult of anti-EBV negative antibody.Main manifestations heating, pharyngalgia, cervical lymph node enlargement, splenomegaly.Peripheral blood lymphocyte increases, and can reach more than 50 ~ 60%, and occur atypical lymphocyte, generally more than 10%.Blood heterophil agglutination test and anti-EBV antibody positive, in the patient having immunodeficiency, can show chronic, recurrent infectious monocytosis.Primary disease good prognosis, main symptomatic treatment.( select from the Internet " Baidupedia ").

Burkitt's lymphoma occurs in a kind of malignant lymphoma in Africa, equator and New Guinea child.Get burkitt's lymphoma cell to cultivate, can find in oncocyte, have EBV gene and EBV specific antigen.In the serum of burkitt's lymphoma patient, there is anti-EBV capsid antigen (VCA) antibody (antibody titer >=1:160, positive rate can reach more than 80%) of high titre, and normal person's high titre VCA antibody positive rate only 5 ~ 15%.Someone, by some monkey class of Epstein-Barr virus experimental infection, causes the malignant lymphatic hamartoplasia pathological changes similar to burkitt's lymphoma.Therefore, think that African children has severe and lasting EBV to infect at infant period at present, the basis of ebv infection occurs malaria infection again, immunologic function is suppressed, tumor gene is activated, and causes bone-marrow-derived lymphocyte malignant proliferation, forms burkitt's lymphoma.( select from the Internet " Baidupedia ").

It may be one of the cause of disease of (especially undifferentiated type nasopharyngeal carcinoma) that nasopharyngeal carcinoma EBV infects.Research proves, is cultivated by nasopharyngeal carcinoma active somatic cell, can find EBV gene and EBV specific antigen in cancerous cell.In Patients With Npc, find multiple EBV antibody simultaneously.In the serum of nasopharyngeal cancer patient and saliva, the titre of EBV Specific IgA antibody and positive rate are all apparently higher than normal person and other tumour patients.Detect EBVIgA antibody, can generally investigate, diagnose, judge sensitivity and the reliability index of curative effect and prognosis as nasopharyngeal cancer patient.( select from the Internet " Baidupedia ").

The EBV of immunodeficiency and organ transplant patients infects, and this type of patient is owing to existing serious immunodeficiency, and in body, the EBV of long-term latent infection is activated, and causes the severe infections of viremia and multiple internal organs, as hepatitis, encephalitis, pneumonia etc.Severe infections or general of whole body sexuality dye all can cause death.( select from the Internet " Baidupedia ").

Ebv infection does not have special medicine at present, and vaccine also under study for action, is treated the surface symptoms correspondence treatment mainly for occurring, but fundamentally can not be eliminated old complaint, be easy to again anti-even cause cancer.

Summary of the invention

Chinese medicine can solve the Treatment defect that treatment epstein-Barr virus infects, infect with Chinese medicine viewpoint analysis epstein-Barr virus, belong to deficiency of YIN-blood, excessive the wetting of wind is held back, warm knot poison, QI and blood resistance numbness and send out that this is sick, treatment should be drawn out pus by applying a plaster to the affected part with enriching yin and nourishing kidney, removing heat from blood and promoting blood circulation, heat clearing away, the Chinese medicine combined treatment of dispelling pathogenic wind and eliminating phlegm.

Taked technical scheme that epstein-Barr virus infects and medicine is dealt with problems combines by each Chinese medicine quality part ratio below: Rhizoma Chuanxiong 10 parts, Flos Lonicerae 20 parts, 15 parts, the Radix Rehmanniae, Fructus Forsythiae 15 parts, 15 parts, Folium Mori, Rhizoma Colocasiae antiquori 15 parts, Fructus Gardeniae 15 parts, Radix Achyranthis Bidentatae 15 parts, Radix Isatidis 15 parts, Scolopendra 10 parts, Carapax Trionycis 15 parts, 7 parts, Radix Glycyrrhizae.

Lower surface analysis epstein-Barr virus infects and property of medicine effect of each Chinese medicine in medicine.Rhizoma Chuanxiong effect: blood-activating and qi-promoting, wind-expelling pain-stopping, activating QI to alleviate the depression, for coronary heart diseases and angina pectoris, disease sees chest distress, pareordia tenderness frequently sends out disease caused by author, stagnation of QI-blood.Flos Lonicerae is sweet cold, and the power of heat-clearing and toxic substances removing, antiviral, dissipation carbuncle is strong, is the important medical material for the treatment of pyretic toxicity carbuncle sore, is applicable to treat outer infections abscess of internal organ, sore throat, erysipelas etc. that various hyperactivity of toxic heat causes.Can external application also can decoction.The Radix Rehmanniae have clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, matter profit the effect of letting out is fallen.Effect of Fructus Forsythiae and effect: attribute: bitter, be slightly cold, return lung, the heart, gallbladder meridian.Fructus Forsythiae has broad-spectrum antibacterial action, has very strong inhibitory action to staphylococcus aureus, Hayes dysentery bacterium, has very strong inhibitory or killing effect to other pathogenic bacterium, influenza virus.Folium Mori are the dried leaves of moraceae plants Mulberry, and have another name called a Mulberry, Jing Sang, Fructus Mori tree, yellow wood etc., national most area has production more.Folium Mori have good inhibitory anti-virus effect, all right dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight, cooling blood for hemostasis.Rhizoma Colocasiae antiquori dispels the wind effect extra-heavy of getting rid of evils, and Rhizoma Colocasiae antiquori is poisonous, can not multiplex, can not stick slag, Rhizoma Colocasiae antiquori cures mainly acute mastitis, toxic swelling, leprosy, scabies, traumatic injury, bee sting.Fructus Gardeniae bitter in the mouth, cold in nature, GUIXIN, liver, lung, stomach warp, have effect of pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain.Fructus Gardeniae soaked energy clearing away heat-fire, relieving restlessness, removing toxic substances, reducing swelling and alleviating pain.Radix Achyranthis Bidentatae, returns kidney channel, energy invigorating the liver and kidney; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow; Draw enemy state's (fire) descending; Inducing diuresis for treating stranguria syndrome.Radix Achyranthis Bidentatae is used for soreness of waist and knee joint, and muscles and bones is unable, amenorrhea and mass in the abdomen, dizziness due to hyperactivity of liver-YANG.Radix Isatidis, also known as indigo-blue, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) root, Radix Clerodenri Cyrtophylli, be a kind of Chinese crude drug, bitter in the mouth, cold; There is heat-clearing and toxic substances removing, effect of the antiviral that dispels the wind, removing heat from blood sore-throat relieving; Be usually used in pestilence seasonal noxious pathogen, heating pharyngalgia, maculae caused by violent heat pathogen.Scolopendra acrid in the mouth, warm in nature, poisonous, enter Liver Channel.Scolopendra function cures mainly: dispel the wind, arresting convulsion, counteracting toxic substances, and eliminating stagnation, controls apoplexy, infantile convulsion, tetanus, pertussis, scrofula, tuberculosis ， mass in the abdomen tumor block, sore swollen toxin, and tinea corporis is bald in vain, anal fistula, scalds; Modern clinic is also used for the treatment of tuberculosis (tuberculous pleuritis, Tuberculous pleuritis, pulmonary tuberculosis, sporadic tuberculosis, bone tuberculosis, tuberculosis of breast and the tuberculosis of cervical lymph nodes etc.), cancer (esophageal carcinoma, breast carcinoma, skin carcinoma, pulmonary carcinoma, uterus carcinoma, adenocarcinoma of lip etc.).Carapax Trionycis, salty, cold, effect: nourishing kidney YANG hyperactivity suppressing, hard masses softening and resolving; Cure mainly: hard under hectic fever due to YIN-deficiency consumptive fever, malaria with splenomegaly, the side of body, lumbago, the diseases such as amenorrhea lump in the abdomen.The invigorating middle warmer of Radix Glycyrrhizae QI invigorating, relieving spasm to stop pain; Nourishing the lung to arrest cough; Eliminating fire and detoxication; The mediation property of medicine.

Epstein-Barr virus infects and the medicine beneficial effect of the invention is: inventor is by infecting with Chinese medicine viewpoint analysis epstein-Barr virus, belong to deficiency of YIN-blood, excessive the wetting of wind is held back, warm knot poison, QI and blood hinders numbness and sends out this disease, draw out pus by applying a plaster to the affected part with enriching yin and nourishing kidney, removing heat from blood and promoting blood circulation, heat clearing away, the Chinese medicine combined treatment of dispelling pathogenic wind and eliminating phlegm, started with the correct theory scheme of traditional Chinese medical herbal treatment Epstein-Ba Ershi two viral infection, and received obvious, stable curative effect.

Detailed description of the invention

Epstein-Barr virus infects and medicine combines by each Chinese medicine quality part ratio below: Rhizoma Chuanxiong 10 parts, Flos Lonicerae 20 parts, 15 parts, the Radix Rehmanniae, Fructus Forsythiae 15 parts, 15 parts, Folium Mori, Rhizoma Colocasiae antiquori 15 parts, Fructus Gardeniae 15 parts, Radix Achyranthis Bidentatae 15 parts, Radix Isatidis 15 parts, Scolopendra 10 parts, Carapax Trionycis 15 parts, 7 parts, Radix Glycyrrhizae.According to above drug ratio ratio, epstein-Barr virus infects and medicine to be suitable for a dose drug that an epstein-Barr virus infected patient takes be combine by each Chinese medicine quality below: Rhizoma Chuanxiong 10 grams, Flos Lonicerae 20 grams, 15 grams, the Radix Rehmanniae, Fructus Forsythiae 15 grams, 15 grams, Folium Mori, Rhizoma Colocasiae antiquori 15 grams, Fructus Gardeniae 15 grams, Radix Achyranthis Bidentatae 15 grams, Radix Isatidis 15 grams, Scolopendra 10 grams, Carapax Trionycis 15 grams, 7 grams, Radix Glycyrrhizae.Using method: decoct soup and take medicinal liquid orally, abandon medicinal residues, day takes dose, serveing on 15 days is a course for the treatment of, can slow down and slightly subtract dose continue to take, until each transference cure after the course for the treatment of according to the state of an illness.

Claims (1)

1. epstein-Barr virus infects and medicine, it is characterized in that combining by each Chinese medicine quality part ratio below: Rhizoma Chuanxiong 10 parts, Flos Lonicerae 20 parts, 15 parts, the Radix Rehmanniae, Fructus Forsythiae 15 parts, 15 parts, Folium Mori, Rhizoma Colocasiae antiquori 15 parts, Fructus Gardeniae 15 parts, Radix Achyranthis Bidentatae 15 parts, Radix Isatidis 15 parts, Scolopendra 10 parts, Carapax Trionycis 15 parts, 7 parts, Radix Glycyrrhizae.